Hub : Genes

THBS4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1240	0.0360	1.2e-04	0.006	0.028	0.032	0.051	0.043	4.9e-02	1.8e-04	7.5e-05	7.9e-07	5.1e-06
2	GTEx	Adipose Visceral Omentum	0.2200	0.0780	1.6e-03	0.013	NA	0.001	NA	0.044	6.4e-02	NA	2.7e-01	NA	2.5e-03
3	GTEx	Cells EBV-transformed lymphocytes	0.2810	0.0730	1.1e-04	0.157	NA	0.138	NA	0.152	8.2e-06	NA	2.9e-05	NA	1.2e-05
4	GTEx	Cells Transformed fibroblasts	0.3430	0.0440	0.0e+00	0.395	NA	0.410	NA	0.397	2.0e-31	NA	6.6e-33	NA	1.3e-31
5	GTEx	Colon Sigmoid	0.2890	0.0880	2.3e-03	0.006	NA	0.045	NA	0.051	1.9e-01	NA	1.1e-02	NA	6.8e-03
6	GTEx	Ovary	0.3270	0.1380	9.2e-03	0.059	NA	0.032	NA	0.047	1.4e-02	NA	5.7e-02	NA	2.7e-02
7	GTEx	Testis	0.2080	0.0740	3.0e-03	-0.006	NA	-0.006	NA	-0.006	7.9e-01	NA	7.5e-01	NA	8.0e-01
8	ROSMAP	Brain Pre-frontal Cortex	0.1276	0.0332	9.1e-06	-0.001	0.033	0.041	0.058	0.026	5.0e-01	3.6e-05	4.4e-06	5.9e-08	2.5e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0656	0.0304	7.3e-05	0.012	0.039	0.033	NA	0.023	1.4e-02	2.8e-05	1.1e-04	NA	1.0e-03
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1470	0.0520	7.5e-07	0.058	0.104	0.070	NA	0.084	3.0e-04	1.4e-06	7.4e-05	NA	1.5e-05
11	TCGA	Lung Adenocarcinoma	0.0384	0.0200	2.7e-03	0.016	0.018	0.010	NA	0.019	4.6e-03	3.1e-03	1.9e-02	NA	2.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.6	2.6	8.9	0.3	-1.6	0.8	1.5	0.2	2.2	0.9	1.5	2.1	3.0	1.3
Bipolar Disorder or Schizophrenia	2.4	5.9	17.1	-0.1	-1.6	2.5	3.0	1.8	2.1	0.9	1.7	3.3	4.1	2.8
Depressed Affect (Nagel 2018)	1.3	2.7	12.5	3.5	-1.6	1.9	1.5	0.3	0.2	1.8	2.2	-0.5	0.3	0.9
Depression (Nagel 2018)	0.7	1.0	3.6	1.9	-1.2	0.2	-0.0	-1.2	-0.2	1.3	0.6	-1.2	-0.8	-0.4
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.8	-1.1	1.7	-1.7	-1.6	1.1	-0.9	-1.7	-1.1	-0.2	-0.5	-0.9
Neuroticism (Nagel 2018)	2.1	5.0	10.4	2.2	-3.2	3.1	2.9	-0.5	2.1	1.7	1.3	1.5	2.0	2.3
Schizophrenia (2018)	1.8	3.8	9.0	-0.3	-0.7	2.5	2.7	2.1	0.9	0.4	0.9	2.4	3.0	2.5
Schizophrenia vs Biploar Disorder	4.6	6.0	11.8	0.2	2.9	-2.9	-3.1	1.8	-3.4	-1.3	0.5	-2.5	-2.7	-3.1
Worry (Nagel 2018)	5.3	11.2	22.2	1.8	-4.7	4.4	4.6	-1.0	3.3	2.2	1.5	3.2	3.8	3.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.9	0.3	-0.0	0.3	-0.0	-0.1	-0.1	-0.9	0.0	0.1	0.7	0.2
Alzheimer’s Disease (in father)	1.1	1.2	3.2	-0.3	1.5	-1.8	-1.5	-0.7	-0.6	0.0	-0.6	-1.4	-1.0	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	-0.1	0.8	-0.8	-0.7	-0.5	-0.8	-0.8	-0.6	-0.7	0.0	-0.7
Crohns Disease (2017)	0.4	0.8	2.3	1.5	-0.3	1.0	1.0	-1.0	0.4	1.5	0.5	0.2	0.6	-0.6
Irritable Bowel Disease (IBD)	0.7	1.8	5.7	1.1	-0.9	1.9	1.4	-2.1	0.9	2.4	0.4	0.1	0.7	0.0
Ulcerative Colitis (UC)	0.8	1.5	6.0	0.1	-0.8	1.7	1.1	-2.0	0.7	2.4	-0.1	0.1	0.6	0.4
Major Depression (MDD)	0.6	0.7	3.1	-0.1	-0.5	-0.4	0.8	-0.0	1.5	0.3	0.6	1.8	1.0	-0.2
Reaction Time	2.1	4.0	10.5	0.9	-1.7	2.8	3.2	-0.8	1.8	0.4	0.4	2.1	2.4	2.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.9	-1.3	0.2	0.3	0.3	0.1	0.6	-0.7	-1.7	0.9	0.2	1.0
Breast Cancer	0.7	1.7	6.3	-0.5	1.7	-0.7	-1.0	2.5	-1.8	-0.8	-0.4	-1.4	-1.2	-0.4
Ovarian Cancer	0.4	0.5	1.6	-0.5	0.2	0.7	0.7	-0.7	1.3	0.6	-0.6	-0.6	0.8	0.6
Prostate Cancer	0.8	1.1	4.1	-0.8	-0.7	1.0	0.4	-2.0	0.1	-1.7	-1.2	0.3	-1.0	0.5
Age at First Birth	0.5	0.7	1.5	-0.6	1.1	-1.2	-0.9	-0.7	0.6	-0.9	-1.0	-0.6	-0.8	-0.8
Bipolar Disorder (2011)	2.6	2.5	7.5	0.8	-0.7	1.6	2.0	0.8	1.5	0.3	2.2	1.5	2.7	1.4
Body Mass Index (BMI) (2010)	1.0	1.4	3.5	0.8	-0.6	1.7	1.3	0.2	1.2	1.2	0.9	1.4	0.9	1.9
Coronary Artery Disease (CAD)	0.7	0.8	1.8	-0.5	0.4	-1.3	-1.3	1.4	-1.3	-0.6	0.3	-0.4	-0.7	-0.8
Crohns Disease (2012)	0.2	0.3	1.1	0.7	-0.1	-0.1	-0.1	-1.1	-0.3	0.9	0.2	-0.4	-0.2	-0.6
Mean Putamen Volume	1.2	1.3	3.1	1.0	0.4	1.8	1.7	1.1	1.0	1.2	0.8	0.5	1.3	1.1
Fasting Glucose	0.5	0.6	1.5	1.2	0.3	0.5	0.2	1.2	0.3	0.6	1.2	-0.7	0.1	-1.0
HbA1C	1.0	1.1	5.7	0.6	0.5	-0.8	-0.7	0.0	-1.1	1.2	0.3	-2.4	-1.2	-0.4
HDL Cholesterol	0.2	0.3	1.3	-1.2	0.2	0.2	0.4	-0.4	-0.5	-0.3	-0.7	0.5	-0.4	0.9
LDL Cholesterol	0.6	0.9	3.8	-0.9	0.5	-1.0	-0.8	-0.5	-1.1	-0.4	-0.8	-1.1	-1.9	0.0
Lupus	0.4	0.6	3.2	0.7	0.5	1.0	0.6	0.0	0.3	1.8	-0.1	0.5	-0.6	0.4
Neuroticism (2016)	2.4	3.5	11.2	2.1	-3.3	2.1	2.1	-1.7	1.4	-0.1	2.1	1.2	1.2	1.0
Primary Biliary Cirrhosis	1.1	1.6	4.4	0.7	-0.9	1.7	1.6	0.2	0.6	2.1	1.1	1.0	1.2	1.4
Rheumatoid Arthritis	1.6	2.2	10.9	2.2	-1.6	-0.8	-0.6	-0.7	0.4	0.3	3.3	-0.6	-0.5	-1.9
Schizophrenia (2014)	0.5	1.0	3.8	0.1	-0.2	1.1	1.2	1.9	-0.3	-0.1	1.0	0.6	1.4	1.3
Triglycerides	0.7	1.2	5.1	-2.2	1.6	-0.7	-0.9	0.6	-0.3	0.3	-1.6	0.9	-0.5	0.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.2	0.4	-0.9	0.8	0.8	-0.1	1.4	0.8	0.7	1.1	1.5	1.0
Ulcerative Colitis	1.1	1.6	6.9	-0.4	-0.8	1.8	1.5	-1.3	1.2	2.6	0.0	0.2	0.6	0.9
Blood Eosinophil Count	0.2	1.2	4.3	0.8	0.5	-2.1	-1.4	0.4	-0.3	-0.7	0.8	-0.6	-0.9	-1.9
Blood Platelet Count	0.0	0.5	1.7	-1.1	0.3	-0.8	-0.5	-0.4	0.3	-1.3	-0.6	0.3	-0.7	-0.6
Blood Red Count	0.3	2.5	5.7	2.4	0.5	-0.8	-1.2	1.3	-1.4	1.9	1.5	-1.2	-1.7	-2.4
Blood White Count	0.8	5.9	12.9	0.1	2.9	-2.6	-3.1	2.6	-2.5	-1.5	0.6	-2.0	-2.9	-3.6
Heel T-Score	0.4	2.9	8.6	-0.5	-2.1	1.3	2.1	-0.5	2.1	0.5	-1.0	1.7	2.9	2.0
BMI	1.3	7.8	15.8	0.7	3.3	-2.8	-3.7	1.4	-3.4	-0.5	-0.2	-3.1	-3.7	-4.0
Height	0.2	4.4	21.2	-4.6	2.7	-0.6	-1.4	0.3	-1.9	1.0	-1.9	-0.8	-2.3	1.7
Waist Hip Ratio (WHR)	0.5	2.4	4.8	-0.9	1.5	-1.7	-1.9	-1.5	-1.6	-0.8	-1.2	-1.5	-2.2	-1.6
Systolic Blood Pressure	0.9	4.5	9.1	0.8	-3.0	2.9	2.5	-1.9	2.5	2.4	-0.7	0.9	1.3	2.5
Smoking Status	3.3	7.9	18.1	-2.3	4.3	-2.7	-3.2	0.9	-2.3	-2.4	-3.1	-2.8	-3.8	-1.5
Allergy or Eczema	0.2	0.6	1.7	0.0	-1.3	0.2	0.3	0.6	0.4	0.0	0.4	1.0	1.3	1.3
Cardiovascular Disease	0.1	0.3	1.5	-0.2	-0.6	0.2	-0.4	-1.2	0.7	-0.1	-0.7	0.2	0.1	-0.2
Hypothyroidism (self reported)	0.4	1.0	2.7	0.5	-1.1	1.0	0.9	-1.0	1.7	0.2	-0.1	0.9	1.6	0.3
Respiratory disease	0.5	1.2	3.5	-1.4	1.9	-1.2	-1.7	0.8	-1.1	0.3	-1.1	0.0	-0.7	-0.0
Type 2 Diabetes (T2D) (2018)	2.4	4.4	10.9	-1.0	2.9	-1.8	-2.6	-0.6	-3.0	0.7	-1.2	-2.3	-3.3	-1.2
Lung FEV1/FVC ratio	0.2	1.1	7.1	1.2	-0.1	-0.5	-0.6	0.4	0.7	-0.0	2.7	0.3	0.5	-1.3
Lung FVC	0.4	2.0	9.2	-0.2	2.0	-1.3	-2.0	3.0	-1.4	-0.1	0.8	-0.9	-0.2	-0.3
Neuroticism	2.3	5.5	12.9	2.6	-3.6	3.3	3.3	-1.4	1.5	1.4	1.7	1.3	1.9	1.9
Chronotype (morning person)	0.9	2.1	5.9	0.9	0.3	-1.0	-0.4	2.4	-1.1	2.4	2.1	-0.2	-0.0	-1.9
Hair Pigment	0.0	1.0	3.0	-1.0	0.5	0.5	0.4	-0.3	-0.7	0.7	-1.7	-1.0	-1.3	1.6
Tanning	0.1	1.0	3.2	-0.5	0.8	-0.7	-1.4	0.3	-1.6	-0.2	-0.9	-1.2	-1.8	-0.3
Hand grip strength (left)	0.7	1.7	3.7	-1.8	0.8	-1.9	-1.9	-0.4	-0.7	-1.6	-0.8	-1.1	-1.1	-1.2
Number of treatments/medications taken	0.7	1.3	3.7	-0.2	0.9	-1.3	-1.9	0.4	-1.6	-1.7	-0.7	-1.1	-1.1	-0.3
Average weekly spirits intake	0.8	1.0	2.4	1.5	-1.1	1.2	1.0	-0.9	0.9	1.2	1.4	0.0	-0.0	0.4
Sensitivity / hurt feelings	2.5	4.2	11.6	0.9	-3.4	2.5	2.3	-2.5	2.5	0.4	-1.1	1.6	2.1	1.5
Frequency of depressed mood in last 2 weeks	1.2	1.7	4.6	2.1	-0.4	-0.8	-0.4	-2.1	-0.7	0.5	1.1	-1.7	-1.5	-1.3
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-1.0	0.5	-0.3	-0.5	-0.5	0.1	-0.0	-0.8	0.5	-0.7	-0.5
Relative age of first facial hair	1.6	3.2	9.2	-2.2	-1.1	1.5	1.6	-0.5	2.3	0.5	-1.4	3.0	1.3	2.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	6.2	-2.4	0.3	0.0	-0.3	0.3	0.2	-0.3	-2.5	1.3	1.2	1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	0.8	0.8	0.0	-0.2	0.1	-0.3	-0.3	-0.3	0.2	-0.2	-0.7
Ever had hysterectomy (womb removed)	1.9	2.1	5.7	2.0	-0.7	-1.0	-1.4	-0.8	-0.4	0.9	2.4	-1.2	-1.3	-2.4
Systolic blood pressure, automated reading	0.3	0.9	4.1	1.2	-2.0	1.0	0.9	-0.5	0.4	1.4	0.1	-0.2	0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.8	-1.1	1.0	-0.9	-1.0	-0.8	-1.0	0.5	-0.2	-1.0	-1.3	-0.4
Angina	1.2	1.6	3.3	0.8	1.7	-0.7	-1.0	1.2	-0.5	-0.5	1.6	-1.4	-1.7	-1.8
Medication for hormone replacement therapy	0.9	1.0	4.5	-0.4	0.9	-0.9	-1.0	-1.0	-0.5	-2.1	-0.9	-0.1	-1.3	-0.6
Vitamin and mineral supplements	0.2	0.3	2.3	-0.1	0.2	0.3	0.6	1.5	0.2	0.1	-0.5	0.4	0.5	0.1
Supplements: Zinc	1.3	1.4	3.9	-1.6	-0.7	-0.1	0.2	0.6	1.9	0.6	-0.8	2.0	1.7	0.7
Medication: Co-codamol	0.8	1.0	5.6	-1.2	-0.4	-0.3	-1.0	-0.5	-0.7	0.1	-2.4	-0.5	-0.5	1.1
Medication: Metformin	3.3	4.6	10.3	-0.1	2.2	-3.0	-3.2	-0.5	-2.5	-0.5	-0.4	-2.1	-2.8	-2.9
Diabetes (father)	0.2	0.3	1.5	0.7	0.2	-0.2	0.1	-0.2	-1.2	0.1	0.4	0.7	-0.5	-0.4
Diabetes (mother)	0.6	0.7	1.9	-0.2	0.6	-0.3	-0.6	-0.4	-0.8	1.1	-1.1	-1.3	-1.4	-0.2
Severe depression (siblings)	1.0	1.1	4.6	0.1	-0.5	0.5	0.8	-0.1	2.1	0.6	0.9	2.0	1.1	-0.2
Pack years adult smoking proportion	0.4	0.6	1.9	-0.4	1.0	0.2	-0.0	-1.4	0.5	-0.1	-0.2	-0.9	-1.2	-1.0
Impedance of leg (right)	0.9	4.3	7.6	1.5	-1.9	2.8	2.5	-1.2	2.0	2.7	2.1	1.4	1.4	2.6
Leg fat-free mass (left)	1.6	8.6	14.7	-3.7	3.8	-3.2	-3.5	1.0	-3.5	-2.3	-2.9	-1.9	-3.0	-2.1
Trunk fat percentage	1.3	5.4	13.0	-0.0	2.6	-2.2	-2.7	0.8	-3.6	-0.3	0.5	-2.7	-3.5	-2.6
Hand grip strength (right)	1.2	3.3	5.8	-2.0	1.8	-2.4	-2.2	-0.2	-1.6	-1.7	-1.7	-2.3	-2.2	-1.0
Townsend deprivation index at recruitment	0.7	1.0	2.8	0.4	1.1	-1.0	-1.3	-0.6	-0.7	0.6	0.6	-0.8	-1.4	-1.7
Current tobacco smoking	0.4	0.7	2.6	-0.0	1.0	0.2	-0.1	0.0	-0.2	0.2	-1.6	-1.6	-1.1	0.1
Average weekly fortified wine intake	0.6	0.7	1.8	1.1	-0.5	1.1	0.6	-1.1	0.4	0.1	0.8	1.3	0.7	-0.6
Maternal smoking around birth	0.7	1.0	3.9	-1.1	0.2	-1.0	-0.8	-2.0	-0.0	-0.6	-1.2	-1.1	-0.5	-0.7
Fed-up feelings	0.9	1.6	4.9	2.2	-1.1	1.2	0.8	-1.6	0.9	1.3	1.6	-0.4	0.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.6	1.5	-1.5	0.8	0.4	-1.6	0.3	0.7	-0.8	-0.5	-0.1	0.7
Relative age voice broke	3.1	4.7	15.1	-2.1	-1.5	1.4	2.1	-1.3	2.8	0.3	-1.7	3.9	2.2	2.5
Taking other prescription medications	0.8	1.2	4.5	2.1	-0.6	0.1	-0.5	-2.1	-0.3	0.0	1.8	-0.0	-0.0	-0.4
Age when periods started (menarche)	0.4	0.9	5.6	-0.8	0.7	1.1	0.9	0.0	1.1	-0.2	-0.5	-0.3	0.1	2.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	0.1	-0.9	-0.5	-0.7	-0.6	0.3	0.3	0.3	-0.0	0.7	0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.7	0.0	1.9	-1.8	-1.4	1.0	-1.9	-0.2	0.5	-2.4	-1.5	-1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.5	-0.4	0.6	0.0	0.4	0.7	1.2	-0.8	0.2	0.1	0.4	-0.2
Qualifications: CSEs or equivalent	2.3	3.0	7.6	-0.7	2.4	-2.1	-1.9	-1.0	-1.2	-1.1	-1.0	-1.7	-2.7	-2.0
Serious illness, injury or assault to yourself	1.6	1.9	5.1	1.0	0.4	-2.0	-2.1	0.2	-1.4	0.7	0.5	-1.4	-1.2	-2.3
High blood pressure	0.2	0.7	2.0	0.3	0.6	-1.0	-1.4	0.5	-0.6	0.8	0.1	-1.0	-0.8	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.2	0.0	-0.8	0.3	0.5	-0.7	0.8	-0.3	0.4	0.6	1.1	1.1
Multivitamins +/- minerals	0.4	0.5	1.7	-0.4	0.1	-1.0	-0.8	-1.3	-0.3	-0.1	0.1	-0.6	-1.1	-0.4
Stomach or abdominal pain in last month	1.1	1.4	5.2	0.5	-0.6	0.1	-0.2	-2.3	0.0	0.2	2.2	-0.9	0.1	-2.0
Supplements: Glucosamine	0.8	1.1	4.0	-1.3	1.1	-2.0	-1.8	0.9	0.2	0.4	-0.8	0.2	0.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.4	-0.5	0.1	-0.8	-0.4	-0.7	-0.5	1.2	0.0	0.1	-0.3	0.6
Medication: Atenolol	1.1	1.3	4.1	1.1	0.5	-0.9	-1.5	-0.0	-0.5	-0.8	2.0	-1.0	-0.9	-1.8
Medication: Levothyroxine sodium	0.2	0.4	1.0	1.0	0.1	-0.1	-0.4	-0.5	-0.2	-0.8	0.7	-0.7	-0.2	-1.0
Sitting height	0.2	1.6	9.8	-3.1	1.4	-0.5	-0.8	0.9	-1.4	0.0	-1.0	0.1	-0.7	0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	4.0	0.7	-0.8	-0.4	-0.1	-1.2	0.4	-0.0	0.7	-2.0	-0.6	-0.5
High blood pressure (mother)	0.1	0.1	0.3	0.2	-0.0	0.4	-0.1	0.5	0.0	0.1	0.2	0.1	0.5	0.4
Body mass index (BMI)	1.9	8.3	18.7	0.0	3.3	-3.5	-3.8	0.9	-3.6	-1.0	-0.3	-2.9	-3.4	-4.3
Impedance of leg (left)	0.7	3.4	7.4	2.0	-1.9	2.1	1.9	-0.8	1.7	2.7	2.5	0.8	1.1	1.8
Leg predicted mass (left)	1.6	8.2	14.1	-3.6	3.8	-3.1	-3.4	1.1	-3.5	-2.3	-2.8	-1.8	-2.9	-2.1
Trunk fat mass	1.9	8.0	18.3	-1.0	3.5	-2.9	-3.5	0.9	-4.3	-0.8	-0.4	-2.9	-4.0	-3.1
Waist circumference	2.8	10.4	19.8	-0.2	3.8	-4.1	-4.4	0.3	-4.3	-0.5	-0.2	-3.2	-3.9	-4.4
Number of incorrect matches in round	0.1	0.2	0.8	0.9	-0.1	-0.1	-0.0	0.3	0.1	-0.6	-0.1	-0.6	0.3	0.2
Past tobacco smoking	3.8	7.1	14.8	2.6	-3.7	3.1	3.4	-0.6	2.5	1.8	1.7	2.2	3.8	1.9
Alcohol usually taken with meals	1.2	2.0	7.7	0.4	-1.0	1.4	1.4	0.7	1.3	0.4	0.4	2.8	2.4	0.9
Nervous feelings	2.9	5.4	11.1	1.5	-3.1	2.9	3.2	-0.5	2.3	0.3	1.0	2.2	3.3	2.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	6.2	2.5	-1.4	0.7	0.8	-0.3	-0.4	0.8	1.1	-1.1	-0.5	0.2
Hearing difficulty/problems with background noise	0.6	0.9	3.3	-1.3	0.3	-0.3	-0.6	-0.8	-1.1	-1.1	-1.8	-0.8	-0.6	-0.4
Hair/balding pattern: Pattern 2	1.7	2.2	5.2	-2.3	1.3	-1.4	-1.9	0.5	-1.9	-0.3	-1.7	-0.1	-2.1	-0.3
Had menopause	1.0	1.2	6.5	1.3	-2.5	0.5	0.9	0.2	0.7	0.9	-0.0	0.7	1.3	0.9
Had other major operations	0.9	1.0	4.5	2.1	-0.2	-0.7	-0.0	-0.7	-0.4	0.4	1.0	-1.3	-0.3	-1.7
Forced vital capacity (FVC)	0.8	3.2	7.8	-1.9	2.8	-1.7	-2.4	1.6	-2.7	-0.7	-0.3	-1.7	-1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.5	-0.6	1.2	-0.8	-0.3	0.6	-1.1	0.0	-0.3	-1.2	-0.9	-0.2
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	4.0	2.0	-1.5	1.0	1.5	-0.4	1.7	0.2	1.6	1.9	1.7	0.1
Qualifications: None of the above	1.6	3.5	6.7	1.3	-0.1	-2.5	-2.5	-1.5	-2.0	-0.4	0.7	-2.3	-2.2	-2.6
Financial difficulties in last 2 years	3.5	4.8	11.0	-0.7	2.7	-3.0	-2.9	0.3	-1.2	-0.5	-0.7	-3.3	-2.7	-2.6
Mouth/teeth dental problems	0.3	0.5	1.7	-0.8	0.4	-0.7	-0.8	0.2	-0.8	0.0	-0.5	-0.6	-0.7	1.3
Heart attack	1.2	1.5	4.0	2.0	0.3	-1.0	-0.8	-0.9	-0.6	0.3	1.1	-2.0	-1.2	-1.8
Allergy	0.2	0.4	0.8	-0.7	-0.1	0.9	0.8	0.9	0.8	-0.0	-0.7	0.5	0.4	0.4
Pain all over the body in last month	0.5	0.5	1.5	-0.6	0.5	-0.9	-0.8	0.9	-0.5	-0.1	-0.9	-1.2	-0.4	0.3
Diabetes (self-reported)	3.0	4.6	13.5	-0.1	2.3	-1.6	-2.3	-0.5	-3.4	1.3	-0.7	-2.4	-3.7	-2.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.9	-0.4	-0.3	-0.0	0.3	-0.5	1.4	-1.1	0.1	1.1	0.5	0.8
Medication: Ramipril	0.5	0.6	2.6	-0.6	1.6	-0.3	-0.5	1.0	-0.7	-0.5	-0.3	-0.5	-1.2	-0.4
Medication: Simvastatin	0.6	0.9	3.2	1.8	-0.3	-0.4	-0.5	0.7	-0.4	0.7	1.8	-1.1	-0.4	-1.1
Fluid intelligence score	0.1	0.3	0.7	-0.5	-0.7	0.2	0.2	-0.2	0.7	-0.3	-0.6	0.5	0.4	0.9
Illnesses of siblings	1.2	1.7	4.5	1.4	-1.2	1.5	1.3	-0.2	1.5	2.1	1.0	0.7	1.0	1.4
Neuroticism score	2.1	4.4	11.9	2.5	-3.5	2.8	2.5	-1.9	1.4	0.7	1.8	1.1	1.6	1.8
Weight	2.0	9.6	18.0	-2.0	3.9	-3.7	-4.2	1.0	-4.2	-1.1	-1.3	-2.7	-3.8	-3.5
Impedance of arm (right)	2.1	9.9	27.4	0.7	-3.3	4.2	4.5	-1.1	3.1	1.5	0.8	2.9	3.3	5.2
Arm fat percentage (right)	0.9	3.5	7.6	0.5	2.1	-2.1	-2.2	0.7	-2.8	-0.5	0.0	-1.9	-2.5	-2.4
Trunk fat-free mass	1.4	8.0	13.9	-3.5	3.7	-3.5	-3.7	1.3	-2.9	-1.6	-2.6	-1.6	-2.6	-2.5
Hip circumference	1.7	7.3	13.7	-0.8	3.6	-3.1	-3.7	1.0	-3.6	-0.0	-0.2	-2.6	-3.1	-3.5
Time employed in main current job	1.6	1.8	6.6	-1.3	-1.6	1.3	1.2	-1.6	0.9	-0.7	-0.7	0.8	0.9	2.6
Alcohol intake versus 10 years previously	6.6	9.9	20.8	-1.4	3.6	-4.6	-4.0	1.9	-4.2	-1.4	0.1	-3.9	-3.7	-2.2
Father’s age at death	0.3	0.4	1.5	-0.4	0.2	0.8	0.4	0.2	0.5	1.2	0.3	0.9	0.4	0.8
Worrier / anxious feelings	3.2	6.1	11.7	0.8	-3.4	2.8	3.3	0.3	2.5	1.4	0.9	2.5	3.1	3.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.0	0.8	-0.0	-0.7	-0.5	-1.1	-0.9	-0.4	0.2	-1.7	-1.2	-1.5
Falls in the last year	0.2	0.2	0.9	0.8	-0.3	0.1	0.0	-0.9	-0.1	0.4	-0.5	-0.4	0.0	0.2
Hair/balding pattern: Pattern 3	2.2	3.3	6.3	2.4	-1.7	1.8	1.7	-0.3	2.2	2.5	2.0	0.3	2.1	1.1
Number of live births	0.5	0.7	3.2	0.4	-0.9	1.8	1.1	-1.0	0.9	0.2	0.3	0.4	0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.5	-0.9	2.1	-1.5	-2.0	1.4	-1.8	-0.2	1.0	-1.3	-0.4	-0.9
Pulse rate	0.5	0.8	2.6	1.3	0.7	1.0	0.6	0.4	0.7	1.3	1.6	0.1	0.2	-0.5
Happiness	1.6	2.0	7.6	2.8	-0.9	0.4	0.5	0.3	0.7	2.0	2.5	1.1	0.8	-0.4
Noisy workplace	0.6	0.8	2.1	0.0	0.6	-0.9	-1.0	-0.8	0.2	-1.5	-0.5	-1.3	-1.0	-0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	5.5	-2.3	0.6	0.9	0.8	0.8	1.0	-0.5	-1.6	1.4	1.0	2.3
Serious illness, injury or assault of a close relative in last 2 years	4.2	4.9	9.2	-1.8	3.0	-2.9	-2.3	2.2	-2.9	-1.6	-1.9	-1.3	-1.6	-1.9
Mouth/teeth dental problems: Dentures	0.2	0.4	1.4	0.3	0.8	0.7	0.5	1.2	-0.3	0.4	-0.1	0.0	-0.5	-1.0
Asthma	0.4	0.7	1.8	-0.1	1.1	-1.0	-1.4	-0.1	-1.0	0.5	-0.8	-0.6	-1.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.4	-0.0	0.1	0.1	-0.4	-0.2	0.0	-0.1	0.5	-0.3	-0.3
Medication: Cholesterol lowering	0.3	0.5	2.1	-0.4	1.3	-0.1	-0.5	0.0	-0.3	-1.5	0.1	-1.0	-0.8	0.2
Depression (self-reported)	1.6	1.9	4.5	1.0	-1.1	1.1	1.4	-0.7	1.5	1.9	1.2	2.1	1.4	1.0
Medication: Lansoprazole	2.2	2.5	7.8	1.1	1.5	-1.8	-2.0	-0.1	-1.8	-0.5	1.1	-1.7	-1.3	-2.8
Prospective memory result	0.4	0.5	1.5	-0.2	1.0	-0.7	-0.9	-0.5	-0.7	-0.2	0.3	-0.8	-0.5	-1.2
Lung cancer (father)	0.4	0.5	1.2	0.6	0.4	-1.0	-1.1	-0.0	-0.7	0.7	0.1	-0.5	-0.7	-0.9
Illnesses of mother	2.0	2.5	5.4	-0.3	-1.0	1.4	1.9	0.9	2.0	0.6	-0.5	2.3	2.3	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.4	-0.6	2.1	-1.1	-1.8	1.4	-1.7	-0.0	0.9	-1.3	-0.2	-0.8
Pulse wave Arterial Stiffness index	1.1	1.3	4.3	-0.8	2.1	-1.1	-1.2	0.5	-1.0	-0.7	0.1	-1.3	-1.7	-0.5
Impedance of arm (left)	2.2	10.3	32.5	0.3	-3.0	4.6	4.8	-0.7	2.8	1.3	1.0	2.8	3.0	5.7
Arm fat mass (right)	1.7	7.1	14.4	-0.5	3.2	-3.1	-3.5	0.8	-3.8	-0.9	-0.5	-2.5	-3.5	-3.4
Trunk predicted mass	1.4	7.9	13.8	-3.4	3.7	-3.5	-3.7	1.3	-2.9	-1.7	-2.6	-1.7	-2.7	-2.5
Standing height	0.3	3.1	19.1	-4.4	1.6	-0.4	-0.9	0.3	-1.7	-0.4	-2.2	0.2	-1.1	1.5
Length of working week for main job	0.5	0.5	1.4	-0.1	0.7	1.1	0.6	-1.0	1.2	-0.1	-0.3	-0.2	-0.9	0.0
Exposure to tobacco smoke at home	0.5	0.5	2.5	-1.1	1.1	0.5	-0.1	0.1	-0.4	0.1	-0.6	0.0	-1.6	0.3
Breastfed as a baby	1.5	1.9	5.0	-1.5	0.7	-2.2	-2.0	0.6	-2.0	-1.2	-0.4	-1.1	-1.5	0.3
Tense / ‘highly strung’	0.9	1.5	4.9	0.7	-1.5	2.2	1.5	-1.9	0.3	0.4	1.0	-0.7	-0.2	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.4	0.2	-0.8	1.5	1.6	-1.0	2.1	1.4	-0.0	1.5	1.9	0.9
Hair/balding pattern: Pattern 4	0.5	1.2	3.1	0.1	0.7	-1.8	-1.0	0.9	-1.5	-1.6	-0.5	-0.9	-0.2	-1.3
Birth weight of first child	0.2	0.4	2.0	0.1	0.2	-0.8	-0.6	0.8	-1.4	-0.8	-0.2	0.4	-0.7	-0.2
Peak expiratory flow (PEF)	0.6	1.4	3.1	-0.7	1.4	-1.6	-1.8	0.7	-1.3	1.2	1.2	-0.7	-0.7	-0.9
Pulse wave reflection index	0.6	0.7	1.7	-0.7	0.6	-0.7	-0.8	-0.9	-0.8	-1.2	-1.0	-0.8	-1.3	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.9	1.0	0.4	0.9	0.4	-0.4	0.9	1.7	1.1	0.2	0.6	-0.8
Loud music exposure frequency	1.8	2.0	7.9	0.6	0.4	-0.7	-1.0	-0.2	-1.5	-0.5	-1.2	-2.4	-2.8	-1.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.1	-0.0	-0.9	1.1	1.4	1.8	1.6	1.0	0.6	0.9	2.0	1.7
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	3.5	1.1	-1.0	0.7	0.7	-1.9	1.3	-0.1	0.6	-0.2	1.1	-0.7
Blood clot in the leg (DVT)	0.6	0.7	2.6	-0.2	0.9	-0.6	-0.6	-0.3	-1.6	-0.4	-0.7	-1.2	-1.2	-0.5
Medication: Paracetamol	0.8	1.3	3.5	-1.0	1.3	-1.0	-1.5	0.7	-1.3	0.4	-0.1	-1.9	-1.5	-0.6
Headache pain in last month	0.4	0.7	4.9	-0.2	-0.6	0.7	0.5	-2.2	1.3	-0.1	-0.2	0.5	0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	8.2	1.5	-2.9	1.3	2.1	-0.7	1.6	2.5	0.9	1.7	1.9	0.7
Glaucoma (self-reported)	1.7	2.0	5.1	2.3	-0.9	0.7	1.5	0.4	1.3	-0.8	2.1	1.7	2.0	0.4
Gout (self-reported)	0.1	0.2	0.5	-0.4	-0.7	-0.0	0.2	-0.6	0.3	0.3	-0.1	0.7	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	1.3	-0.6	1.1	0.7	-0.5	1.0	0.1	0.3	0.4	1.2	0.1
Medication: Amlodipine	0.3	0.4	1.7	0.8	-0.4	0.1	-0.6	-0.8	-0.2	-0.4	1.3	-1.0	-0.4	-0.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.9	-0.5	-0.6	1.4	0.9	0.7	0.4	1.4	-1.0	0.7	0.2	0.9
Birth weight	0.4	0.8	2.5	0.6	-0.1	0.7	0.2	-1.4	1.2	-1.6	-1.4	0.3	-0.1	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.1	0.3	-1.2	-0.4	-0.0	-0.8	0.4	-0.0	0.6	-0.5	-0.1	-1.5
High blood pressure (siblings)	1.9	2.8	6.1	-1.6	1.9	-2.1	-1.8	1.8	-2.5	-2.2	-1.1	-0.0	-0.9	-1.0
Forced vital capacity (FVC), Best measure	0.6	2.2	6.3	-1.2	2.5	-1.1	-2.0	1.4	-2.3	-0.2	0.1	-1.7	-0.7	-0.8
Body fat percentage	1.4	5.5	12.1	0.3	2.6	-2.4	-2.8	0.7	-3.5	-0.2	0.5	-2.6	-3.5	-2.9
Leg fat percentage (right)	1.4	5.1	10.3	0.5	2.7	-2.3	-2.9	0.4	-3.2	0.0	0.3	-2.3	-3.1	-3.1
Arm fat-free mass (right)	2.4	12.1	23.8	-2.7	4.3	-4.4	-4.9	1.2	-3.9	-1.9	-1.6	-2.9	-4.1	-4.1
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.6	0.6	-0.2	0.0	-0.7	0.7	0.2	-0.4	0.4	-0.5	-0.1
Comparative body size at age 10	0.3	1.0	2.9	0.9	-0.2	-1.7	-1.2	0.6	-1.6	1.0	-0.1	-0.8	0.6	-0.6
Number of full brothers	0.8	1.0	3.3	-0.3	-0.7	0.3	0.6	-1.8	1.8	0.2	-0.6	1.7	0.6	-0.1
Worry too long after embarrassment	2.1	3.5	10.0	0.9	-3.2	2.4	2.8	-0.3	1.5	0.0	0.9	1.6	2.3	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.4	0.8	-0.7	1.5	1.4	-0.9	0.9	1.9	0.2	1.2	0.3	0.6
Wheeze or whistling in the chest in last year	1.6	2.9	6.2	-0.3	0.6	-2.1	-2.0	-2.5	-1.3	-0.8	-1.4	-2.1	-2.1	-1.9
Number of children fathered	0.4	0.5	1.2	-0.4	-0.9	0.7	0.3	-0.6	0.5	1.1	-0.7	-0.7	0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.4	-0.6	0.2	-0.8	-0.5	0.7	-0.6	-1.6	-0.5	-0.3	0.4	0.8
Age at first live birth	1.0	1.8	7.8	-2.8	1.0	-0.8	-0.1	1.5	0.2	-1.4	-2.1	0.8	0.9	0.2
Pulse wave peak to peak time	0.7	0.8	2.9	0.4	-1.7	0.8	1.0	-0.3	0.5	0.5	-0.4	1.1	1.5	0.5
Health satisfaction	0.6	0.8	2.7	1.7	-0.6	-0.9	-1.1	-0.4	-0.6	-0.1	0.9	-0.8	-0.5	-1.3
Shortness of breath walking on level ground	0.3	0.4	1.6	1.2	0.1	-0.2	-0.1	-1.3	0.2	-0.0	0.8	0.3	0.0	-0.7
Qualifications: College or University degree	0.6	1.8	5.3	-1.0	0.3	1.4	1.0	1.0	1.1	-1.9	-0.6	1.9	2.3	1.1
Eye problems/disorders: None of the above	0.2	0.2	1.4	0.3	-1.2	0.2	0.1	-0.8	-0.2	-0.1	-0.2	-0.0	0.1	0.4
Mouth/teeth dental problems: Loose teeth	1.9	2.2	6.6	1.3	-1.0	1.4	1.6	1.0	1.7	2.6	1.6	1.1	1.3	1.1
Emphysema/chronic bronchitis	0.6	0.7	2.0	0.9	-0.6	0.3	1.0	-1.0	0.7	-0.9	0.4	0.9	1.4	0.2
Medication for pain relief, constipation, heartburn	0.7	1.2	3.2	0.4	-1.3	1.2	1.6	-0.3	1.2	-0.1	-0.6	1.3	1.8	0.7
Neck or shoulder pain in last month	0.5	0.8	2.2	0.8	0.8	-0.1	-0.3	-1.2	-0.5	0.3	1.5	-1.2	-1.2	-0.4
Medication: Blood pressure	1.7	3.0	7.6	-1.5	2.8	-1.4	-2.1	0.6	-1.4	-1.3	-0.8	-2.5	-2.2	-0.9
Angina (self-reported)	1.1	1.4	2.8	0.8	1.6	-0.5	-0.8	1.2	-0.6	-0.3	1.7	-1.1	-1.6	-1.6
Migraine (self-reported)	1.1	1.4	5.8	1.1	-2.4	0.5	0.9	-1.4	1.2	0.9	1.4	0.9	0.6	-0.1
Medication: Ibuprofen	0.1	0.2	0.4	-0.3	0.3	-0.3	-0.6	0.4	-0.5	-0.2	-0.3	0.0	-0.6	-0.4
Medication: Allopurinol	0.2	0.2	0.5	-0.6	-0.7	0.2	0.2	-0.4	0.7	0.6	0.2	0.3	-0.0	-0.0
Medication: Omeprazole	2.5	3.0	11.4	1.5	0.8	-1.0	-1.6	2.0	-3.4	-0.0	1.0	-2.4	-1.9	-0.6
Medication: Seretide 50 evohaler	0.6	0.6	1.4	0.3	-1.2	0.9	0.9	0.3	0.4	0.3	-1.1	-0.1	1.1	1.1
Mean time to correctly identify matches	1.2	2.3	7.0	0.4	-1.3	1.8	2.2	0.1	1.0	0.2	-0.2	2.0	1.8	2.6
Heart disease (mother)	1.7	2.1	4.9	-0.7	1.5	-1.1	-1.3	-1.8	-1.7	0.2	-0.0	-1.7	-2.2	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	3.5	0.9	-1.0	1.2	1.9	0.4	0.0	1.1	0.6	0.1	1.3	1.2
Whole body fat mass	2.0	8.4	17.3	-1.1	3.7	-3.1	-3.7	0.9	-4.2	-0.8	-0.7	-2.9	-4.1	-3.2
Leg fat mass (right)	2.0	7.9	15.9	-1.0	3.7	-3.0	-3.8	0.8	-4.0	-0.8	-1.0	-2.6	-3.8	-3.2
Arm predicted mass (right)	2.3	11.8	22.6	-2.7	4.2	-4.4	-4.8	1.1	-4.0	-1.7	-1.7	-2.8	-4.0	-4.0
Pulse rate, automated reading	0.2	0.8	5.8	0.2	2.4	-0.4	-0.8	0.6	-0.3	-0.1	0.7	-0.3	-0.5	-0.7
Alcohol intake frequency.	1.1	2.5	5.0	1.4	0.6	-2.2	-2.0	-0.3	-1.9	0.8	0.5	-2.0	-1.9	-2.0
Comparative height size at age 10	0.3	1.6	5.2	-1.9	1.0	-1.1	-1.4	-0.3	-2.3	0.0	-1.3	-1.3	-1.3	0.1
Number of full sisters	0.4	0.5	2.0	0.4	-0.3	-0.9	-1.0	0.6	-0.1	-1.4	0.9	-0.4	-0.4	-0.3
Suffer from ‘nerves’	4.6	7.3	15.6	2.1	-4.0	3.1	3.5	-2.1	2.6	1.6	1.3	2.5	3.5	2.1
Overall health rating	0.6	1.2	2.9	0.5	0.6	-1.3	-1.3	-1.4	-0.7	-0.7	-0.9	-1.2	-1.1	-1.7
Chest pain or discomfort	0.9	1.2	4.7	1.8	-0.3	-0.2	-0.3	-2.2	0.3	-0.8	1.4	0.0	-0.5	-1.6
Had major operations	0.1	0.2	0.5	-0.2	0.5	-0.2	-0.4	0.3	0.3	-0.2	-0.7	0.5	-0.5	-0.3
Age at last live birth	0.6	0.9	3.2	-1.6	1.4	-0.2	-0.3	0.1	-0.2	-1.1	-1.8	0.5	0.3	-0.3
Family relationship satisfaction	0.6	0.8	3.6	-0.2	0.2	0.5	0.3	-1.2	1.2	-1.9	-0.5	1.0	0.6	-0.2
Leg pain on walking	1.5	1.9	4.8	-0.2	1.3	-2.2	-2.2	-0.3	-2.0	-0.6	-0.6	-0.1	-1.5	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.2	-1.1	2.0	-1.1	-0.9	0.1	-0.8	-0.2	-0.7	-1.8	-2.0	-0.5
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.2	0.6	0.5	-1.0	-1.6	-0.7	-0.8	-0.0	0.4	-1.6	-2.3	-2.0
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	8.1	0.0	-1.1	2.8	2.6	0.2	1.3	0.5	0.5	2.4	2.0	2.6
Medication: Aspirin	0.3	0.4	1.0	-0.0	0.5	0.9	0.8	-0.2	0.6	0.6	0.4	0.6	1.0	0.7
Supplements: Vitamin C	0.7	0.9	3.7	-0.1	0.9	-0.9	-1.4	0.8	-0.4	-1.9	-0.0	-0.6	-0.4	-1.0
Knee pain experienced in last month	0.5	0.8	3.4	-0.7	0.6	-0.3	-1.1	-1.0	-0.4	0.7	-1.8	-0.4	-1.2	-0.5
Hypertension (Self-reported)	0.2	0.5	1.9	0.4	0.6	-0.8	-1.4	0.4	-0.3	0.9	0.1	-0.9	-0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	5.3	1.3	-0.4	-0.4	-0.1	1.7	-1.3	1.0	2.3	-0.7	-0.4	-0.2
Illnesses of father: Heart disease	0.4	0.5	2.1	0.2	-1.2	0.4	0.3	-1.0	0.7	0.4	1.5	0.3	0.4	-0.1
Illnesses of siblings: Diabetes	2.6	3.2	7.1	-1.4	2.6	-2.2	-2.7	0.4	-1.4	-0.1	-1.0	-1.8	-1.5	-2.5
Smoking status: Previous	4.3	6.4	12.3	-2.7	3.5	-3.0	-3.3	0.4	-2.7	-2.0	-1.6	-1.9	-3.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.1	-1.1	1.5	0.0	-0.5	-0.6	-0.3	-0.5	-0.2	-1.3	-0.8	-0.1
Whole body fat-free mass	1.6	9.2	15.4	-3.5	3.9	-3.6	-3.9	1.2	-3.4	-2.0	-2.6	-1.9	-3.0	-2.8
Leg fat-free mass (right)	1.6	8.3	12.8	-3.4	3.6	-3.4	-3.5	1.0	-3.5	-2.3	-2.6	-1.9	-2.9	-2.5
Arm fat percentage (left)	1.0	3.8	8.9	0.4	2.4	-1.9	-2.2	0.8	-3.0	-0.6	0.2	-2.1	-2.8	-2.4
Average weekly red wine intake	1.1	1.6	3.5	-0.3	-0.9	1.9	1.5	-0.2	1.6	0.0	-0.6	1.8	1.9	1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.8	1.6	-0.8	-0.1	0.4	0.4	-1.0	0.9	1.7	-0.9	-0.3	-0.6
Mood swings	1.0	1.8	6.4	2.5	-1.0	1.6	1.2	-0.2	0.3	1.9	1.9	-0.1	-0.4	0.6
Loneliness, isolation	1.2	1.7	6.9	2.6	-1.1	-0.4	-0.0	-0.8	-0.4	1.7	2.0	-1.3	0.1	-1.0
Long-standing illness, disability or infirmity	1.5	2.3	5.3	-0.8	2.3	-1.7	-2.1	-1.1	-1.8	-0.8	-1.2	-1.6	-1.2	-0.9
Ever had bowel cancer screening	1.1	1.3	3.7	-1.8	1.2	-1.3	-1.9	0.1	-0.4	1.3	-0.9	0.2	-1.0	-1.1
Diabetes diagnosed by doctor	3.0	4.9	13.1	-0.1	2.8	-1.8	-2.6	-1.0	-3.1	1.2	-0.5	-2.6	-3.6	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.3	0.2	1.1	-0.3	-0.3	-1.8	0.5	0.4	-0.4	-0.9	-1.4	-0.9
Friendships satisfaction	2.1	2.6	6.9	1.7	-1.1	2.0	1.4	-0.7	2.1	0.8	0.7	2.6	1.9	1.5
Qualifications: nursing, teaching	0.8	1.2	2.9	-0.6	-1.2	1.7	1.4	-0.3	1.4	-0.5	-0.5	1.3	1.3	0.8
Commuting to job workplace: Walk	0.5	0.5	1.8	1.0	-1.3	0.3	0.9	0.2	-0.5	0.3	1.3	0.1	0.1	0.1
Eye problems/disorders: Cataract	0.2	0.3	1.0	-0.4	1.0	-0.1	-0.3	-0.2	-0.7	1.0	0.1	-0.1	-0.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	-0.3	-0.9	0.6	0.8	0.7	0.9	0.1	-0.1	1.4	1.4	0.4
Medication for cholesterol	0.1	0.2	0.6	-0.2	0.3	0.0	0.7	-0.3	-0.1	0.8	0.5	-0.5	0.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.2	1.5	0.1	-1.0	-1.2	0.8	-1.0	-1.3	1.4	-1.3	-1.1	-0.7
Back pain experienced in last month	3.2	4.7	11.3	1.8	1.1	-2.6	-2.5	-1.4	-3.0	0.2	0.4	-3.4	-2.4	-2.5
Mineral and other dietary supplements	0.3	0.3	1.2	0.6	0.6	1.1	1.0	-0.0	-0.3	-0.2	-0.4	-0.6	-0.6	0.2
Breast cancer (self-reported)	0.9	1.1	4.3	0.9	-0.5	-0.9	-0.3	2.1	-0.7	-1.7	1.0	1.1	0.4	-0.7
Asthma (self-reported)	0.3	0.7	1.7	0.1	1.1	-1.0	-1.3	-0.4	-1.0	0.5	-0.6	-0.6	-1.0	-0.6
Osteoporosis (self-reported)	0.5	0.6	2.4	0.4	-0.7	1.1	1.1	-0.1	-0.0	0.1	0.2	0.4	0.9	1.5
Osteoarthritis (self-reported)	3.8	5.0	10.3	-2.0	2.6	-2.2	-2.9	2.7	-3.2	-1.0	-2.4	-1.4	-2.0	-0.6
Medication: Aspirin	0.3	0.4	1.2	0.3	0.8	0.8	0.6	-0.3	0.6	1.1	0.5	0.2	0.6	0.4
Medication: Gliclazide	3.3	3.7	6.7	0.9	1.9	-2.1	-2.2	-1.3	-2.4	-0.3	0.9	-2.3	-2.6	-2.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	0.1	0.4	1.3	0.6	0.4	1.3	0.2	-0.2	0.1	-0.3	0.9
Smoking status: Current	0.3	0.5	1.8	0.0	1.1	0.4	0.1	0.2	-0.0	-0.0	-1.3	-1.3	-1.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	3.9	1.4	1.4	-1.2	-1.7	1.1	-1.9	0.6	1.8	-2.0	-0.9	-1.5
Whole body water mass	1.7	9.6	16.7	-3.5	4.0	-3.8	-4.1	1.2	-3.5	-1.9	-2.6	-2.0	-3.2	-3.0
Leg predicted mass (right)	1.5	8.0	12.4	-3.4	3.5	-3.3	-3.5	1.1	-3.4	-2.3	-2.6	-1.8	-2.8	-2.3
Arm fat mass (left)	1.5	6.0	13.5	-0.3	2.9	-2.7	-3.1	0.7	-3.7	-0.9	-0.3	-2.5	-3.2	-3.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.3	-0.0	1.4	-0.8	-1.2	-0.6	-1.5	-1.1	-0.7	-1.2	-1.2	-0.6
Average weekly champagne plus white wine intake	1.4	1.9	6.1	-1.6	-0.7	1.3	1.3	0.1	1.0	-0.3	-1.5	2.1	1.0	2.5
Miserableness	0.9	1.5	5.2	2.3	-1.5	1.6	1.3	-1.1	0.4	0.7	1.6	0.3	0.5	0.6
Guilty feelings	0.3	0.5	2.2	0.5	-0.4	0.4	0.6	0.2	0.6	-1.1	-0.8	-0.1	1.5	0.5
Wears glasses or contact lenses	1.0	1.1	4.5	-1.4	1.5	-0.8	-1.0	2.1	-0.9	-0.8	-0.6	-0.5	-0.3	0.1
Ever taken oral contraceptive pill	1.9	2.2	5.7	-0.4	2.3	-1.7	-1.2	-0.0	-0.6	-2.4	0.7	-0.4	-1.6	-2.2
Hearing aid user	2.4	2.7	6.1	-0.1	-1.6	2.4	2.5	0.0	1.4	-0.7	-1.2	2.1	1.9	1.9
Mother’s age at death	1.5	1.9	9.4	-1.8	0.1	0.8	0.5	-0.5	0.6	0.5	-3.1	1.7	0.9	1.8
Financial situation satisfaction	0.8	0.9	2.5	1.3	-1.6	1.0	1.2	-0.7	1.5	-0.7	0.3	0.5	0.5	0.1
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.6	1.9	-1.8	1.9	1.7	0.6	0.4	0.6	1.3	0.5	1.4	1.0
Commuting to job workplace: Public transport	1.0	1.1	6.1	-1.2	1.3	0.1	-0.0	2.5	0.0	-0.6	-1.5	-0.2	-0.2	0.9
Eye problems/disorders: Glaucoma	1.4	1.7	4.2	1.3	-0.5	1.1	1.8	0.3	1.3	-1.0	0.9	1.9	2.0	0.9
Medication: Blood pressure	0.5	0.9	3.6	1.4	-1.9	0.3	0.0	0.5	0.8	1.1	1.1	0.8	0.8	-0.0
Pain type(s) experienced in last month: Hip pain	0.6	0.8	4.8	0.8	0.1	-0.5	-1.1	-2.2	-0.6	-0.3	-0.3	-0.6	-0.5	-0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	-0.6	0.1	-0.8	-1.0	0.5	-0.5	0.0	0.5	0.1	-0.2	-0.5
High cholesterol (Self-reported)	0.3	0.5	1.9	0.7	0.6	-0.7	-0.7	0.3	-0.5	0.3	0.8	-1.4	-0.6	-0.4
Medication: Bendroflumethiazide	0.5	0.8	3.4	-0.9	1.1	-0.6	-0.7	1.8	-0.1	0.4	-1.4	-0.0	-0.4	0.0
Medication: Paracetamol	0.4	0.6	1.9	-0.1	0.9	-0.7	-1.1	1.0	-0.8	-0.2	-0.1	-1.4	-0.9	-0.2
Medication: Lisinopril	0.6	0.7	2.5	-0.5	0.9	-1.4	-1.6	0.9	-0.1	-0.8	-0.4	-0.4	-0.6	-0.5
Medication: Atorvastatin	0.5	0.6	4.1	-0.8	2.0	0.9	0.3	0.2	-0.5	-0.4	-0.5	0.5	0.1	0.6
Illnesses of father: High blood pressure	2.5	3.1	9.0	-0.7	1.9	-2.6	-2.5	2.1	-3.0	-0.9	-0.2	-1.2	-0.9	-1.0
Alcohol drinker status: Never	0.6	0.8	3.1	-0.2	-1.8	-0.3	0.3	-1.4	0.7	0.4	-0.6	1.2	0.9	0.1
Ever smoked	2.6	4.6	9.6	-1.6	2.7	-2.7	-2.8	1.3	-1.9	-0.7	-1.4	-2.5	-3.1	-1.6
Basal metabolic rate	1.7	9.6	16.6	-3.3	4.0	-3.7	-4.1	1.1	-3.6	-2.0	-2.5	-2.1	-3.3	-3.0
Leg fat percentage (left)	1.8	6.6	13.1	0.9	2.8	-2.7	-3.3	0.8	-3.5	0.1	0.5	-2.8	-3.4	-3.6
Arm fat-free mass (left)	2.0	10.1	20.0	-2.3	3.8	-4.1	-4.5	0.9	-3.6	-1.7	-1.8	-2.5	-3.5	-4.0
Number of operations (self-reported)	1.1	1.7	3.5	0.9	-1.9	1.3	1.8	-0.9	1.7	-0.1	-0.4	1.8	1.1	1.0
Average weekly beer plus cider intake	0.4	0.6	2.4	0.9	0.2	-0.7	-0.3	-1.5	-0.5	-0.5	0.0	-1.1	-1.0	-0.2
Irritability	0.5	0.8	2.1	0.4	1.4	-0.5	-1.2	0.0	-0.9	0.2	1.4	-0.6	-1.5	0.1
Risk taking	0.4	0.6	1.8	-0.6	1.3	-0.1	0.1	-0.4	0.6	-0.5	-1.2	-0.9	-1.3	0.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	-0.2	-1.0	0.8	0.9	-0.8	0.1	0.3	-0.3	0.6	0.5	0.8
Fractured/broken bones in last 5 years	0.8	1.0	6.5	-0.5	0.4	0.8	0.6	2.5	-0.1	0.9	-0.3	1.0	0.3	1.3
Age started oral contraceptive pill	0.8	1.0	4.9	0.8	-1.2	-0.5	-0.3	0.4	0.5	0.2	1.2	2.2	1.3	-0.3
Diastolic blood pressure, automated reading	0.2	0.5	1.0	0.7	0.1	-1.0	-0.8	0.8	-0.4	1.0	0.3	-0.9	-0.7	-0.6
Ever depressed for a whole week	1.6	2.0	6.1	0.6	-0.9	1.2	1.6	-0.1	2.1	-0.5	0.1	2.5	2.1	1.3
Unable to work because of sickness or disability	1.2	1.5	6.2	1.8	0.4	-0.4	-0.8	-1.5	-1.1	-0.1	0.4	-2.5	-1.4	-0.9
Commuting to job workplace: Cycle	3.3	4.0	8.6	0.7	-1.5	2.4	2.9	0.9	2.0	1.5	0.6	2.5	2.6	2.7
Myopia	1.4	2.0	5.2	0.1	1.7	-2.0	-2.3	1.9	-1.5	-0.8	0.1	-1.5	-0.7	-0.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.3	-0.0	-0.9	1.2	1.5	-0.6	0.6	0.2	0.3	1.0	0.9	1.2
Cholesterol lowering medication	0.5	0.7	2.1	0.9	0.5	-0.7	-1.1	0.4	-0.9	0.7	0.9	-0.6	-0.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	9.0	1.3	0.1	-0.8	-1.3	1.4	-3.0	0.1	1.3	-1.9	-1.7	-0.5
Pain experienced in last month	1.7	2.9	9.0	-0.7	-0.2	1.9	2.1	3.0	1.2	-0.9	0.1	2.0	1.7	2.3
Supplements: Calcium	0.4	0.5	1.8	-1.3	-0.4	0.3	-0.2	0.8	0.3	0.2	-0.8	1.1	-0.1	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	2.1	0.8	-0.4	0.3	0.1	0.5	0.9	1.3	0.8	0.7	1.4	0.2
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.2	2.1	0.3	-0.8	-0.6	-0.9	-0.6	0.7	1.3	-1.9	-1.2	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.4	0.0	0.9	-0.9	-0.9	-0.6	-2.1	-0.7	-0.4	-1.6	-1.6	-1.0
Heart disease (siblings)	1.4	1.8	4.3	-2.1	1.2	-0.6	-1.1	0.2	-1.6	-1.5	-1.7	-1.1	-1.7	-0.5
Alcohol drinker status: Previous	2.2	2.5	5.4	1.0	1.6	-2.3	-2.2	0.9	-2.2	-0.4	0.1	-1.5	-1.4	-1.8
Pack years of smoking	0.4	0.6	1.9	-0.5	0.9	0.0	-0.1	-1.4	0.6	-0.2	-0.2	-0.7	-1.1	-1.1
Impedance of whole body	1.5	7.6	17.0	1.4	-3.1	4.0	3.9	-1.2	2.5	2.0	2.1	1.8	2.2	4.1
Leg fat mass (left)	2.3	9.0	18.4	-0.6	3.7	-3.3	-4.0	1.1	-4.3	-0.8	-0.7	-3.0	-3.9	-3.7
Arm predicted mass (left)	2.0	10.4	21.3	-2.4	3.8	-4.3	-4.6	1.0	-3.7	-1.4	-1.8	-2.4	-3.5	-4.1