TWAS hub - THEM5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1803	0.0620	0.00012	0.025	NA	0.100	NA	0.058	0.0064	NA	1.4e-07	NA	5.7e-05
2	METSIM	Adipose	0.0277	0.0132	0.00360	0.006	0.013	-0.001	0.012	0.003	0.0400	0.0044	4.3e-01	0.0057	9.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hypothyroidism (self reported)	6.1	13.9	27.2	0.8	5.2
Medication: Omeprazole	5.9	7.0	7.9	2.8	2.5
Ever depressed for a whole week	5.0	6.2	11.0	1.2	3.3
Hypothyroidism/myxoedema (self-reported)	4.7	9.2	17.6	0.9	4.2
Medication: Omeprazole (e.g. Zanprol)	4.6	5.6	7.0	2.6	2.1
Serious illness, injury or assault to yourself	4.4	5.3	10.6	-0.1	3.3
Age at first live birth	4.2	7.4	9.8	2.2	3.1
Age at last live birth	3.8	5.5	10.1	1.0	3.2
Prostate Cancer	3.6	5.1	5.8	-2.4	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.5	9.1	1.4	3.0
Ulcerative Colitis	3.5	5.1	9.3	3.0	0.9
Current tobacco smoking	3.5	5.7	8.4	1.7	-2.9
Breastfed as a baby	3.5	4.4	8.5	0.4	2.9
Irritable Bowel Disease (IBD)	3.3	7.9	15.4	3.9	0.5
Chest pain or discomfort	3.3	4.7	5.1	2.1	2.2
Smoking status: Current	3.3	5.3	8.2	1.6	-2.9
Noisy workplace	3.2	3.9	6.6	1.1	-2.6
Crohns Disease (2017)	3.1	6.8	13.4	3.7	-0.3
Ulcerative Colitis (UC)	3.1	5.9	10.0	3.2	1.3
Osteoarthritis (self-reported)	3.1	4.0	7.3	-0.8	-2.7
Bipolar Disorder (2018)	2.9	4.5	9.0	-0.3	3.0
Bipolar Disorder or Schizophrenia	2.9	7.1	14.1	-0.2	3.8
Severe depression (siblings)	2.9	3.3	4.2	1.5	2.1
Commuting to job workplace: Walk	2.8	3.0	6.0	0.2	-2.4
Tinnitus: Yes, now most or all of the time	2.8	3.2	4.8	-1.3	2.2
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	3.9	1.8	2.0
Mouth/teeth dental problems: Dentures	2.7	4.6	6.6	-1.6	-2.6
Blood clot in the leg (DVT)	2.7	3.5	3.6	1.9	1.9
Smoking status: Previous	2.7	4.1	7.8	0.6	2.8
Supplements: Fish oil (including cod liver oil)	2.7	3.5	3.6	1.8	-1.9
Fractured/broken bones in last 5 years	2.7	3.4	6.5	0.6	2.5
Hair/balding pattern: Pattern 4	2.6	6.4	12.2	0.8	3.5
Medication: Gliclazide	2.6	3.0	5.9	0.3	-2.4
Heart disease (siblings)	2.6	3.2	4.5	1.4	-2.1
Alcohol usually taken with meals	2.5	4.0	7.7	0.5	2.8
Wheeze or whistling in the chest in last year	2.5	4.5	8.8	0.4	-3.0
Hearing difficulty/problems with background noise	2.4	3.9	7.8	-0.1	2.8
Prospective memory result	2.4	2.9	5.1	-0.9	-2.3
Medication: Paracetamol	2.4	3.9	4.5	1.8	-2.1
Hayfever, allergic rhinitis or eczema	2.3	5.0	9.8	3.1	-0.5
Length of working week for main job	2.3	2.5	4.6	0.7	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.5	4.9	2.2	-0.2
Medication: Paracetamol	2.3	3.5	5.8	1.1	-2.4
Diabetes (father)	2.2	2.7	4.5	2.1	1.0
Ever had hysterectomy (womb removed)	2.1	2.4	4.4	-2.1	-0.6
Crohns Disease (2012)	2.0	3.2	6.2	2.5	-0.4
Townsend deprivation index at recruitment	2.0	2.8	4.3	2.1	-1.2
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	4.8	0.3	2.2
Medication for pain relief, constipation, heartburn	2.0	3.5	6.7	-2.6	0.5
Qualifications: nursing, teaching	2.0	3.2	5.9	0.7	2.4
Wears glasses or contact lenses	2.0	2.3	4.4	-0.5	2.1
Qualifications: CSEs or equivalent	1.9	2.6	4.9	0.5	-2.2
Worrier / anxious feelings	1.9	3.7	4.9	1.6	2.2
Pulse rate	1.9	3.3	4.2	2.1	1.5
Medication: Ibuprofen	1.9	2.3	4.6	2.2	0.0
Illnesses of mother	1.8	2.3	2.4	-1.5	-1.6
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.5	2.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	4.3	0.6	2.1
Migraine (self-reported)	1.8	2.2	3.8	-2.0	-0.7
Mineral and other dietary supplements	1.8	2.4	4.6	-2.1	0.5
Number of operations (self-reported)	1.8	2.6	5.2	-2.3	0.2
Supplements: Calcium	1.8	2.0	3.6	0.6	1.9
Schizophrenia vs Biploar Disorder	1.7	2.3	3.5	1.9	-1.1
Coronary Artery Disease (CAD)	1.7	2.0	3.1	1.8	0.9
Schizophrenia (2014)	1.7	3.7	6.2	-1.1	2.5
Past tobacco smoking	1.7	3.1	3.9	-1.5	-2.0
Allergy	1.7	3.9	7.7	-2.8	0.3
Loud music exposure frequency	1.7	1.8	2.0	-1.3	1.4
Worry too long after embarrassment	1.7	2.8	3.8	1.4	1.9
Medication: Blood pressure	1.7	3.1	5.3	2.3	0.9
Medication: Aspirin	1.7	2.2	4.0	0.7	2.0
Average weekly champagne plus white wine intake	1.7	2.3	4.1	-0.7	-2.0
Breast Cancer	1.6	3.9	7.8	-2.8	-0.1
Average weekly spirits intake	1.6	2.0	2.3	1.5	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.9	2.0	-0.5
Alcohol intake versus 10 years previously	1.6	2.4	2.7	1.4	-1.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.2	0.0	2.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	3.3	-1.8	-1.4
Glaucoma (self-reported)	1.6	1.9	3.3	1.8	0.7
Osteoporosis (self-reported)	1.6	2.0	2.5	1.6	1.2
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.3	1.8	0.2
Respiratory disease	1.5	3.3	6.6	-0.2	-2.6
Chronic bronchitis/emphysema (father)	1.5	1.8	3.6	-0.0	-1.9
Angina (self-reported)	1.5	1.9	2.2	1.5	1.3
Risk taking	1.5	2.2	3.4	1.8	-1.0
Depression (Nagel 2018)	1.4	2.1	3.3	1.8	1.0
Schizophrenia (2018)	1.4	3.0	5.6	-0.6	2.4
Allergy or Eczema	1.4	3.6	7.2	2.7	0.2
Medication: Metformin	1.4	1.9	3.6	1.9	-0.6
High blood pressure (mother)	1.4	2.0	3.2	1.8	0.8
Hearing aid user	1.4	1.6	2.1	1.4	-1.0
Major Depression (MDD)	1.3	1.5	3.0	-0.2	1.7
Neuroticism (2016)	1.3	1.9	3.3	1.8	0.7
Number of treatments/medications taken	1.3	2.3	4.4	2.1	0.4
Angina	1.3	1.8	2.5	1.6	1.0
Nervous feelings	1.3	2.4	4.8	0.0	2.2
Medication: Allopurinol	1.3	1.7	2.9	1.7	0.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.7	-1.6	-0.8
Lupus	1.2	1.8	3.4	-0.5	1.8
Primary Biliary Cirrhosis	1.2	1.7	2.3	-1.5	1.0
Chronotype (morning person)	1.2	2.7	4.1	1.1	-2.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	1.8	1.1	1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.8	-1.7	0.2
Diabetes (self-reported)	1.2	1.8	3.5	1.9	0.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.9	1.7	0.6
Medication: Ramipril	1.2	1.6	2.3	1.5	-1.0
Knee pain experienced in last month	1.2	1.8	3.6	1.9	0.2
Asthma (self-reported)	1.2	2.4	4.5	0.4	-2.1
Waist Hip Ratio (WHR)	1.1	4.8	9.4	3.1	0.4
Supplements: Zinc	1.1	1.1	1.3	-1.1	-1.0
Qualifications: None of the above	1.1	2.3	4.6	0.2	-2.1
Mouth/teeth dental problems	1.1	1.6	2.3	1.5	0.9
Asthma	1.1	2.1	4.0	0.4	-2.0
Peak expiratory flow (PEF)	1.1	2.6	5.0	0.5	2.2
Birth weight	1.1	2.4	2.8	-1.7	-1.4
Emphysema/chronic bronchitis	1.1	1.3	1.6	-1.3	1.0
Neck or shoulder pain in last month	1.1	1.6	2.4	-1.6	-0.9
Heart disease (mother)	1.1	1.4	1.4	-1.1	1.2
Arm predicted mass (right)	1.1	5.4	8.1	-1.6	-2.9
Had major operations	1.1	1.3	2.5	-1.6	0.3
Mood swings	1.1	2.0	4.1	-0.0	-2.0
Guilty feelings	1.1	1.7	2.8	0.7	1.7
Ever smoked	1.1	2.0	3.3	1.8	0.9
Ever had prostate specific antigen (PSA) test	1.1	1.2	1.9	0.7	1.4
Pain experienced in last month	1.1	1.8	2.5	1.1	1.6
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.6	1.6	0.6
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.2	1.0	2.3
Bipolar Disorder (2011)	1.0	1.0	1.6	-0.6	1.3
Maternal smoking around birth	1.0	1.5	1.5	1.2	-1.2
Medication: Atenolol	1.0	1.2	2.4	-1.6	-0.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.2	0.6	-1.5
Heart attack	1.0	1.2	2.0	1.4	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	2.9	-1.7	0.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	-0.5	-1.5
Diabetes diagnosed by doctor	1.0	1.7	3.4	1.9	0.1
Commuting to job workplace: Public transport	1.0	1.2	1.3	1.2	1.0
Eye problems/disorders: Glaucoma	1.0	1.2	1.2	1.1	1.1
Age at First Birth	0.9	1.3	2.5	-0.3	1.6
Smoking Status	0.9	2.2	2.7	1.6	-1.3
Lung FVC	0.9	4.8	5.8	-2.4	1.9
Sensitivity / hurt feelings	0.9	1.5	2.9	1.7	0.2
Trunk fat percentage	0.9	3.6	4.6	1.6	-2.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.7	-1.3	-0.5
Pain all over the body in last month	0.9	1.0	1.7	1.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.9	2.0	2.7	1.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.2	1.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.4	1.6	0.0
Birth weight of first child	0.9	1.7	3.2	1.8	0.4
Body fat percentage	0.9	3.5	4.5	1.6	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.1	1.0	1.1
Qualifications: College or University degree	0.9	2.7	5.5	0.1	2.3
Whole body fat mass	0.9	3.6	6.3	0.9	-2.5
Illnesses of siblings: Diabetes	0.9	1.2	2.2	0.4	1.5
Long-standing illness, disability or infirmity	0.9	1.4	1.9	1.4	1.0
Back pain experienced in last month	0.9	1.3	2.0	-0.8	-1.4
Age started oral contraceptive pill	0.9	1.1	2.2	-1.5	-0.1
Worry (Nagel 2018)	0.8	1.7	2.7	0.8	1.7
Body Mass Index (BMI) (2010)	0.8	1.1	1.3	-1.2	-0.9
Blood Eosinophil Count	0.8	6.1	12.2	-3.5	-0.0
Taking other prescription medications	0.8	1.3	1.9	0.8	1.4
Medication: Levothyroxine sodium	0.8	1.3	2.6	-0.3	1.6
Trunk fat mass	0.8	3.4	5.7	1.1	-2.4
Fluid intelligence score	0.8	1.7	3.3	-0.4	1.8
Weight	0.8	3.9	7.7	0.4	-2.8
Arm fat percentage (right)	0.8	3.1	3.8	1.9	-1.5
Pulse wave Arterial Stiffness index	0.8	0.9	1.7	0.2	-1.3
Arm fat-free mass (right)	0.8	4.3	6.2	-1.5	-2.5
Pulse wave peak to peak time	0.8	0.9	1.8	-0.2	1.3
Family relationship satisfaction	0.8	1.0	1.1	1.1	0.9
Illnesses of father: Heart disease	0.8	1.1	1.3	1.1	1.0
Arm fat percentage (left)	0.8	3.0	3.6	1.6	-1.9
Alcohol drinker status: Never	0.8	0.9	1.1	-1.0	0.9
Leg fat percentage (left)	0.8	3.0	4.1	1.4	-2.0
Leg fat mass (left)	0.8	3.3	5.6	1.0	-2.4
Reaction Time	0.7	1.4	2.9	-0.1	-1.7
Triglycerides	0.7	1.2	1.3	-1.1	-1.1
Blood Red Count	0.7	7.1	11.7	-1.6	3.4
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.7	-0.2	-1.3
Number of incorrect matches in round	0.7	1.1	2.1	-1.5	-0.1
Falls in the last year	0.7	1.0	1.0	1.0	1.0
Medication: Cholesterol lowering	0.7	1.1	1.1	1.1	1.0
Leg fat mass (right)	0.7	2.9	5.1	0.9	-2.2
Suffer from ‘nerves’	0.7	1.0	1.8	0.6	1.3
Leg pain on walking	0.7	0.9	1.6	-0.5	-1.3
Average weekly red wine intake	0.7	1.0	1.9	-0.3	1.4
Loneliness, isolation	0.7	1.0	1.7	0.5	-1.3
Eye problems/disorders: Cataract	0.7	0.9	1.5	-1.2	-0.4
Medication: Aspirin	0.7	0.9	1.7	0.1	1.3
Arm fat mass (left)	0.7	2.9	4.9	1.0	-2.2
High cholesterol (Self-reported)	0.7	1.3	2.2	0.6	1.5
Medication: Atorvastatin	0.7	0.9	1.3	1.1	0.7
Basal metabolic rate	0.7	3.6	7.1	-0.3	-2.7
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.9	-0.0	1.7
HbA1C	0.6	0.6	1.2	-0.1	-1.1
Blood Platelet Count	0.6	6.4	8.5	-2.1	-2.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	1.5	-0.1
Neuroticism	0.6	1.5	1.8	1.1	1.3
Leg fat-free mass (left)	0.6	3.2	6.5	-0.1	-2.5
Stomach or abdominal pain in last month	0.6	0.8	1.5	0.0	1.2
Supplements: Glucosamine	0.6	0.8	0.9	0.9	-0.9
Leg predicted mass (left)	0.6	3.3	6.5	-0.1	-2.5
Financial difficulties in last 2 years	0.6	0.9	1.7	1.3	0.2
Neuroticism score	0.6	1.3	2.1	1.4	0.6
Impedance of arm (right)	0.6	3.0	6.0	2.4	0.2
Trunk fat-free mass	0.6	3.2	5.5	-1.0	-2.3
Time employed in main current job	0.6	0.7	1.2	0.4	1.1
Happiness	0.6	0.8	1.2	-1.1	0.6
Depression (self-reported)	0.6	0.7	1.2	1.1	0.5
Trunk predicted mass	0.6	3.3	5.6	-1.0	-2.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.7	1.3	0.4
Medication: Amlodipine	0.6	0.8	1.3	1.2	0.5
Leg fat percentage (right)	0.6	2.2	3.0	1.2	-1.7
Number of full brothers	0.6	0.8	1.0	0.8	1.0
Eye problems/disorders: None of the above	0.6	0.7	1.1	0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.1	0.6	-1.4
Whole body fat-free mass	0.6	3.5	6.5	-0.8	-2.5
Leg fat-free mass (right)	0.6	3.4	6.8	-0.1	-2.6
Ever had bowel cancer screening	0.6	0.7	0.9	-0.7	-0.9
Whole body water mass	0.6	3.4	6.2	-0.8	-2.5
Leg predicted mass (right)	0.6	3.4	6.8	-0.1	-2.6
Ever taken oral contraceptive pill	0.6	0.7	1.2	0.4	1.1
Arm fat-free mass (left)	0.6	3.0	5.3	-0.8	-2.3
Average weekly beer plus cider intake	0.6	0.9	1.7	0.2	-1.3
Alcohol drinker status: Previous	0.6	0.7	1.3	1.1	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	0.9	0.4	1.0
Multivitamins +/- minerals	0.5	0.6	1.2	1.1	0.1
Waist circumference	0.5	2.0	2.0	1.4	-1.4
Number of live births	0.5	0.8	1.3	-1.1	-0.5
Arm fat mass (right)	0.5	2.2	3.5	1.0	-1.9
Mean time to correctly identify matches	0.5	1.0	2.0	-0.1	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	1.0	0.4
Breast cancer (self-reported)	0.5	0.7	1.3	-1.1	-0.0
Number of self-reported non-cancer illnesses	0.5	0.8	1.2	1.1	0.7
Commuting to job workplace: Cycle	0.5	0.6	1.1	0.2	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.6	-1.6	-0.6
Cholesterol lowering medication	0.5	0.8	1.5	1.2	0.2
Pack years of smoking	0.5	0.8	1.5	-1.2	-0.2
Arm predicted mass (left)	0.5	2.6	4.5	-0.8	-2.1
Heel T-Score	0.4	3.2	6.2	0.5	2.5
Medication: Co-codamol	0.4	0.5	0.9	-0.4	-0.9
Pack years adult smoking proportion	0.4	0.7	0.8	-0.9	-0.8
Fed-up feelings	0.4	0.7	1.2	1.1	-0.3
Body mass index (BMI)	0.4	1.9	3.4	0.6	-1.8
Forced vital capacity (FVC)	0.4	1.5	3.0	-1.7	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.7	1.3	-0.2
Pulse wave reflection index	0.4	0.5	0.8	-0.9	-0.4
Comparative body size at age 10	0.4	1.2	1.9	-1.4	-0.6
Pulse rate, automated reading	0.4	1.4	1.8	1.0	1.4
Alcohol intake frequency.	0.4	1.0	1.9	-0.4	-1.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.1	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.2	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.6	1.1	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	-1.3	-0.0
Miserableness	0.4	0.6	1.2	0.3	-1.1
Mother’s age at death	0.4	0.5	0.9	-0.2	0.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.1	0.5	-1.1
Neuroticism (Nagel 2018)	0.3	0.8	1.3	1.1	0.4
Height	0.3	5.9	11.3	-0.8	-3.4
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.9	1.0	0.2
Hand grip strength (right)	0.3	0.8	1.5	0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	1.2	0.1
High blood pressure	0.3	1.0	1.7	1.3	0.5
Illnesses of siblings	0.3	0.4	0.7	-0.3	0.8
Hip circumference	0.3	1.5	3.0	0.1	-1.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.5	-1.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.2	-1.1	0.6
Impedance of arm (left)	0.3	1.4	2.8	1.7	0.0
Gout (self-reported)	0.3	0.5	0.8	0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	-0.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.9	-0.1
Financial situation satisfaction	0.3	0.4	0.7	0.8	-0.4
Medication: Blood pressure	0.3	0.6	0.8	0.6	-0.9
Medication: Bendroflumethiazide	0.3	0.5	1.0	0.1	-1.0
HDL Cholesterol	0.2	0.3	0.6	-0.8	0.2
BMI	0.2	1.3	2.2	0.6	-1.5
Cardiovascular Disease	0.2	0.6	1.1	-0.4	1.1
Hand grip strength (left)	0.2	0.5	1.0	0.0	-1.0
Sitting height	0.2	1.2	2.5	-0.2	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.4	0.6	0.4
Had menopause	0.2	0.2	0.2	-0.4	0.5
Had other major operations	0.2	0.2	0.4	-0.1	0.6
Medication: Simvastatin	0.2	0.3	0.3	0.6	0.4
Medication: Lansoprazole	0.2	0.2	0.4	-0.2	-0.6
Standing height	0.2	2.3	4.3	-0.6	-2.1
High blood pressure (siblings)	0.2	0.2	0.4	-0.7	-0.0
Forced vital capacity (FVC), Best measure	0.2	0.8	1.6	-1.3	0.1
Number of children fathered	0.2	0.2	0.4	0.1	0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.6	-0.3
Comparative height size at age 10	0.2	1.4	2.7	-0.1	-1.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.8	-0.0
Illnesses of father: High blood pressure	0.2	0.3	0.4	0.3	0.7
Irritability	0.2	0.4	0.6	-0.4	-0.8
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.4	-0.6
Impedance of whole body	0.2	1.1	2.2	1.5	0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.2	-0.3	-0.5
Ovarian Cancer	0.1	0.1	0.2	0.3	-0.4
LDL Cholesterol	0.1	0.1	0.2	0.2	0.4
Rheumatoid Arthritis	0.1	0.2	0.3	0.1	-0.6
Systolic Blood Pressure	0.1	0.4	0.5	-0.5	0.7
Lung FEV1/FVC ratio	0.1	0.7	1.2	1.1	0.5
Hair Pigment	0.1	1.9	2.2	1.5	-1.3
Tanning	0.1	1.0	1.6	-1.3	-0.7
Systolic blood pressure, automated reading	0.1	0.2	0.3	-0.4	0.5
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	-0.5
Vitamin and mineral supplements	0.1	0.2	0.4	-0.6	-0.1
Diabetes (mother)	0.1	0.1	0.2	0.4	0.2
Impedance of leg (right)	0.1	0.4	0.8	0.9	0.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.1	-0.4
Relative age voice broke	0.1	0.1	0.2	-0.1	0.4
Age when periods started (menarche)	0.1	0.1	0.3	0.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.2	0.3	0.5
Impedance of leg (left)	0.1	0.6	1.1	1.1	-0.1
Lung cancer (father)	0.1	0.1	0.2	0.1	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.1	-0.4
Headache pain in last month	0.1	0.2	0.3	-0.5	0.4
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.3	0.4
Shortness of breath walking on level ground	0.1	0.2	0.2	0.4	-0.4
Number of full sisters	0.1	0.1	0.2	-0.5	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.2	-0.5	-0.3
Hypertension (Self-reported)	0.1	0.4	0.6	0.8	0.3
Medication for cholesterol	0.1	0.1	0.2	-0.2	0.5
Medication: Lisinopril	0.1	0.2	0.2	0.3	0.5
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.3	0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	-0.1
Mean Putamen Volume	0.0	0.0	0.0	-0.1	0.1
Fasting Glucose	0.0	0.0	0.0	0.2	-0.1
Blood White Count	0.0	0.1	0.1	0.2	0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	-0.1	0.1
Relative age of first facial hair	0.0	0.0	0.0	0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.1	-0.0
Father’s age at death	0.0	0.0	0.1	-0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.4	0.1
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	0.2
Health satisfaction	0.0	0.1	0.1	-0.2	0.3
Overall health rating	0.0	0.0	0.1	-0.3	-0.1
Supplements: Vitamin C	0.0	0.0	0.1	-0.2	-0.0
Friendships satisfaction	0.0	0.0	0.0	0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.0	-0.0
Diastolic blood pressure, automated reading	0.0	0.0	0.0	-0.1	-0.1
Myopia	0.0	0.1	0.1	-0.3	0.2

Hub : Genes

THEM5

Models

Trait associations