Hub : Genes

THEM5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.1803 0.0620 0.00012 0.025 NA 0.100 NA 0.058 0.0064 NA 1.4e-07 NA 5.7e-05
2 METSIM Adipose 0.0277 0.0132 0.00360 0.006 0.013 -0.001 0.012 0.003 0.0400 0.0044 4.3e-01 0.0057 9.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.9 4.5 9.0 -0.3 3.0
Bipolar Disorder or Schizophrenia 2.9 7.1 14.1 -0.2 3.8
Depressed Affect (Nagel 2018) 0.3 0.7 1.1 0.5 -1.1
Depression (Nagel 2018) 1.4 2.1 3.3 1.8 1.0
Intelligence (Savage-Jansen 2018) 1.0 3.0 5.2 1.0 2.3
Neuroticism (Nagel 2018) 0.3 0.8 1.3 1.1 0.4
Schizophrenia (2018) 1.4 3.0 5.6 -0.6 2.4
Schizophrenia vs Biploar Disorder 1.7 2.3 3.5 1.9 -1.1
Worry (Nagel 2018) 0.8 1.7 2.7 0.8 1.7
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 -0.1 -0.1
Alzheimer’s Disease (in father) 0.5 0.5 0.9 0.4 1.0
Alzheimer’s Disease (including proxy) 0.1 0.2 0.2 -0.3 -0.5
Crohns Disease (2017) 3.1 6.8 13.4 3.7 -0.3
Irritable Bowel Disease (IBD) 3.3 7.9 15.4 3.9 0.5
Ulcerative Colitis (UC) 3.1 5.9 10.0 3.2 1.3
Major Depression (MDD) 1.3 1.5 3.0 -0.2 1.7
Reaction Time 0.7 1.4 2.9 -0.1 -1.7
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.9 -0.0 1.7
Breast Cancer 1.6 3.9 7.8 -2.8 -0.1
Ovarian Cancer 0.1 0.1 0.2 0.3 -0.4
Prostate Cancer 3.6 5.1 5.8 -2.4 -2.1
Age at First Birth 0.9 1.3 2.5 -0.3 1.6
Bipolar Disorder (2011) 1.0 1.0 1.6 -0.6 1.3
Body Mass Index (BMI) (2010) 0.8 1.1 1.3 -1.2 -0.9
Coronary Artery Disease (CAD) 1.7 2.0 3.1 1.8 0.9
Crohns Disease (2012) 2.0 3.2 6.2 2.5 -0.4
Mean Putamen Volume 0.0 0.0 0.0 -0.1 0.1
Fasting Glucose 0.0 0.0 0.0 0.2 -0.1
HbA1C 0.6 0.6 1.2 -0.1 -1.1
HDL Cholesterol 0.2 0.3 0.6 -0.8 0.2
LDL Cholesterol 0.1 0.1 0.2 0.2 0.4
Lupus 1.2 1.8 3.4 -0.5 1.8
Neuroticism (2016) 1.3 1.9 3.3 1.8 0.7
Primary Biliary Cirrhosis 1.2 1.7 2.3 -1.5 1.0
Rheumatoid Arthritis 0.1 0.2 0.3 0.1 -0.6
Schizophrenia (2014) 1.7 3.7 6.2 -1.1 2.5
Triglycerides 0.7 1.2 1.3 -1.1 -1.1
Type 2 Diabetes (T2D) (2012) 1.5 1.7 3.3 1.8 0.2
Ulcerative Colitis 3.5 5.1 9.3 3.0 0.9
Blood Eosinophil Count 0.8 6.1 12.2 -3.5 -0.0
Blood Platelet Count 0.6 6.4 8.5 -2.1 -2.9
Blood Red Count 0.7 7.1 11.7 -1.6 3.4
Blood White Count 0.0 0.1 0.1 0.2 0.3
Heel T-Score 0.4 3.2 6.2 0.5 2.5
BMI 0.2 1.3 2.2 0.6 -1.5
Height 0.3 5.9 11.3 -0.8 -3.4
Waist Hip Ratio (WHR) 1.1 4.8 9.4 3.1 0.4
Systolic Blood Pressure 0.1 0.4 0.5 -0.5 0.7
Smoking Status 0.9 2.2 2.7 1.6 -1.3
Allergy or Eczema 1.4 3.6 7.2 2.7 0.2
Cardiovascular Disease 0.2 0.6 1.1 -0.4 1.1
Hypothyroidism (self reported) 6.1 13.9 27.2 0.8 5.2
Respiratory disease 1.5 3.3 6.6 -0.2 -2.6
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.2 1.5 -0.1
Lung FEV1/FVC ratio 0.1 0.7 1.2 1.1 0.5
Lung FVC 0.9 4.8 5.8 -2.4 1.9
Neuroticism 0.6 1.5 1.8 1.1 1.3
Chronotype (morning person) 1.2 2.7 4.1 1.1 -2.0
Hair Pigment 0.1 1.9 2.2 1.5 -1.3
Tanning 0.1 1.0 1.6 -1.3 -0.7
Hand grip strength (left) 0.2 0.5 1.0 0.0 -1.0
Number of treatments/medications taken 1.3 2.3 4.4 2.1 0.4
Average weekly spirits intake 1.6 2.0 2.3 1.5 -1.3
Sensitivity / hurt feelings 0.9 1.5 2.9 1.7 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.9 1.0 0.2
Hearing difficulty/problems: Yes 0.0 0.0 0.0 -0.1 0.1
Relative age of first facial hair 0.0 0.0 0.0 0.1 0.1
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 1.8 1.1 1.3
Ever used hormone-replacement therapy (HRT) 0.7 0.8 1.7 -0.2 -1.3
Ever had hysterectomy (womb removed) 2.1 2.4 4.4 -2.1 -0.6
Systolic blood pressure, automated reading 0.1 0.2 0.3 -0.4 0.5
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.0 0.1 -0.0
Angina 1.3 1.8 2.5 1.6 1.0
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.1 -0.5
Vitamin and mineral supplements 0.1 0.2 0.4 -0.6 -0.1
Supplements: Zinc 1.1 1.1 1.3 -1.1 -1.0
Medication: Co-codamol 0.4 0.5 0.9 -0.4 -0.9
Medication: Metformin 1.4 1.9 3.6 1.9 -0.6
Diabetes (father) 2.2 2.7 4.5 2.1 1.0
Diabetes (mother) 0.1 0.1 0.2 0.4 0.2
Severe depression (siblings) 2.9 3.3 4.2 1.5 2.1
Pack years adult smoking proportion 0.4 0.7 0.8 -0.9 -0.8
Impedance of leg (right) 0.1 0.4 0.8 0.9 0.3
Leg fat-free mass (left) 0.6 3.2 6.5 -0.1 -2.5
Trunk fat percentage 0.9 3.6 4.6 1.6 -2.1
Hand grip strength (right) 0.3 0.8 1.5 0.2 -1.2
Townsend deprivation index at recruitment 2.0 2.8 4.3 2.1 -1.2
Current tobacco smoking 3.5 5.7 8.4 1.7 -2.9
Average weekly fortified wine intake 0.1 0.1 0.2 0.1 -0.4
Maternal smoking around birth 1.0 1.5 1.5 1.2 -1.2
Fed-up feelings 0.4 0.7 1.2 1.1 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 3.9 2.0 -0.5
Relative age voice broke 0.1 0.1 0.2 -0.1 0.4
Taking other prescription medications 0.8 1.3 1.9 0.8 1.4
Age when periods started (menarche) 0.1 0.1 0.3 0.0 0.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 1.7 -1.3 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.5 1.2 0.1
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.2 0.3 0.5
Qualifications: CSEs or equivalent 1.9 2.6 4.9 0.5 -2.2
Serious illness, injury or assault to yourself 4.4 5.3 10.6 -0.1 3.3
High blood pressure 0.3 1.0 1.7 1.3 0.5
Hayfever, allergic rhinitis or eczema 2.3 5.0 9.8 3.1 -0.5
Multivitamins +/- minerals 0.5 0.6 1.2 1.1 0.1
Stomach or abdominal pain in last month 0.6 0.8 1.5 0.0 1.2
Supplements: Glucosamine 0.6 0.8 0.9 0.9 -0.9
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 2.8 -1.7 0.2
Medication: Atenolol 1.0 1.2 2.4 -1.6 -0.1
Medication: Levothyroxine sodium 0.8 1.3 2.6 -0.3 1.6
Sitting height 0.2 1.2 2.5 -0.2 -1.6
Chronic bronchitis/emphysema (father) 1.5 1.8 3.6 -0.0 -1.9
High blood pressure (mother) 1.4 2.0 3.2 1.8 0.8
Body mass index (BMI) 0.4 1.9 3.4 0.6 -1.8
Impedance of leg (left) 0.1 0.6 1.1 1.1 -0.1
Leg predicted mass (left) 0.6 3.3 6.5 -0.1 -2.5
Trunk fat mass 0.8 3.4 5.7 1.1 -2.4
Waist circumference 0.5 2.0 2.0 1.4 -1.4
Number of incorrect matches in round 0.7 1.1 2.1 -1.5 -0.1
Past tobacco smoking 1.7 3.1 3.9 -1.5 -2.0
Alcohol usually taken with meals 2.5 4.0 7.7 0.5 2.8
Nervous feelings 1.3 2.4 4.8 0.0 2.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.4 0.6 0.4
Hearing difficulty/problems with background noise 2.4 3.9 7.8 -0.1 2.8
Hair/balding pattern: Pattern 2 1.0 1.3 2.2 0.6 -1.5
Had menopause 0.2 0.2 0.2 -0.4 0.5
Had other major operations 0.2 0.2 0.4 -0.1 0.6
Forced vital capacity (FVC) 0.4 1.5 3.0 -1.7 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.7 1.3 -0.2
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 4.8 0.3 2.2
Qualifications: None of the above 1.1 2.3 4.6 0.2 -2.1
Financial difficulties in last 2 years 0.6 0.9 1.7 1.3 0.2
Mouth/teeth dental problems 1.1 1.6 2.3 1.5 0.9
Heart attack 1.0 1.2 2.0 1.4 0.7
Allergy 1.7 3.9 7.7 -2.8 0.3
Pain all over the body in last month 0.9 1.0 1.7 1.3 -0.5
Diabetes (self-reported) 1.2 1.8 3.5 1.9 0.2
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 2.9 1.7 0.6
Medication: Ramipril 1.2 1.6 2.3 1.5 -1.0
Medication: Simvastatin 0.2 0.3 0.3 0.6 0.4
Fluid intelligence score 0.8 1.7 3.3 -0.4 1.8
Illnesses of siblings 0.3 0.4 0.7 -0.3 0.8
Neuroticism score 0.6 1.3 2.1 1.4 0.6
Weight 0.8 3.9 7.7 0.4 -2.8
Impedance of arm (right) 0.6 3.0 6.0 2.4 0.2
Arm fat percentage (right) 0.8 3.1 3.8 1.9 -1.5
Trunk fat-free mass 0.6 3.2 5.5 -1.0 -2.3
Hip circumference 0.3 1.5 3.0 0.1 -1.7
Time employed in main current job 0.6 0.7 1.2 0.4 1.1
Alcohol intake versus 10 years previously 1.6 2.4 2.7 1.4 -1.6
Father’s age at death 0.0 0.0 0.1 -0.3 -0.1
Worrier / anxious feelings 1.9 3.7 4.9 1.6 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 0.4 0.1
Falls in the last year 0.7 1.0 1.0 1.0 1.0
Hair/balding pattern: Pattern 3 1.0 1.5 2.9 -1.7 0.3
Number of live births 0.5 0.8 1.3 -1.1 -0.5
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.5 -1.2 0.7
Pulse rate 1.9 3.3 4.2 2.1 1.5
Happiness 0.6 0.8 1.2 -1.1 0.6
Noisy workplace 3.2 3.9 6.6 1.1 -2.6
Qualifications: A levels/AS levels or equivalent 0.9 2.0 2.7 1.6 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 1.2 1.1 -1.0
Mouth/teeth dental problems: Dentures 2.7 4.6 6.6 -1.6 -2.6
Asthma 1.1 2.1 4.0 0.4 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 2.4 1.6 0.0
Medication: Cholesterol lowering 0.7 1.1 1.1 1.1 1.0
Depression (self-reported) 0.6 0.7 1.2 1.1 0.5
Medication: Lansoprazole 0.2 0.2 0.4 -0.2 -0.6
Prospective memory result 2.4 2.9 5.1 -0.9 -2.3
Lung cancer (father) 0.1 0.1 0.2 0.1 -0.4
Illnesses of mother 1.8 2.3 2.4 -1.5 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.2 -1.1 0.6
Pulse wave Arterial Stiffness index 0.8 0.9 1.7 0.2 -1.3
Impedance of arm (left) 0.3 1.4 2.8 1.7 0.0
Arm fat mass (right) 0.5 2.2 3.5 1.0 -1.9
Trunk predicted mass 0.6 3.3 5.6 -1.0 -2.4
Standing height 0.2 2.3 4.3 -0.6 -2.1
Length of working week for main job 2.3 2.5 4.6 0.7 -2.1
Exposure to tobacco smoke at home 0.1 0.1 0.1 0.3 0.2
Breastfed as a baby 3.5 4.4 8.5 0.4 2.9
Tense / ‘highly strung’ 0.0 0.0 0.0 0.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 3.6 5.5 9.1 1.4 3.0
Hair/balding pattern: Pattern 4 2.6 6.4 12.2 0.8 3.5
Birth weight of first child 0.9 1.7 3.2 1.8 0.4
Peak expiratory flow (PEF) 1.1 2.6 5.0 0.5 2.2
Pulse wave reflection index 0.4 0.5 0.8 -0.9 -0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.1 -0.4
Loud music exposure frequency 1.7 1.8 2.0 -1.3 1.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.7 1.3 0.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 4.2 0.0 2.0
Blood clot in the leg (DVT) 2.7 3.5 3.6 1.9 1.9
Medication: Paracetamol 2.4 3.9 4.5 1.8 -2.1
Headache pain in last month 0.1 0.2 0.3 -0.5 0.4
Medication for cholesterol, blood pressure or diabetes 1.6 2.7 3.3 -1.8 -1.4
Glaucoma (self-reported) 1.6 1.9 3.3 1.8 0.7
Gout (self-reported) 0.3 0.5 0.8 0.9 -0.4
Hypothyroidism/myxoedema (self-reported) 4.7 9.2 17.6 0.9 4.2
Medication: Amlodipine 0.6 0.8 1.3 1.2 0.5
Medication: Ventolin 100micrograms inhaler 1.8 2.3 4.5 2.1 -0.1
Birth weight 1.1 2.4 2.8 -1.7 -1.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.5 -0.7 -0.4
High blood pressure (siblings) 0.2 0.2 0.4 -0.7 -0.0
Forced vital capacity (FVC), Best measure 0.2 0.8 1.6 -1.3 0.1
Body fat percentage 0.9 3.5 4.5 1.6 -2.1
Leg fat percentage (right) 0.6 2.2 3.0 1.2 -1.7
Arm fat-free mass (right) 0.8 4.3 6.2 -1.5 -2.5
Exposure to tobacco smoke outside home 0.1 0.1 0.1 -0.3 0.4
Comparative body size at age 10 0.4 1.2 1.9 -1.4 -0.6
Number of full brothers 0.6 0.8 1.0 0.8 1.0
Worry too long after embarrassment 1.7 2.8 3.8 1.4 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 4.3 0.6 2.1
Wheeze or whistling in the chest in last year 2.5 4.5 8.8 0.4 -3.0
Number of children fathered 0.2 0.2 0.4 0.1 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.1 1.0 1.1
Age at first live birth 4.2 7.4 9.8 2.2 3.1
Pulse wave peak to peak time 0.8 0.9 1.8 -0.2 1.3
Health satisfaction 0.0 0.1 0.1 -0.2 0.3
Shortness of breath walking on level ground 0.1 0.2 0.2 0.4 -0.4
Qualifications: College or University degree 0.9 2.7 5.5 0.1 2.3
Eye problems/disorders: None of the above 0.6 0.7 1.1 0.5 -1.1
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.1 -0.5 -1.5
Emphysema/chronic bronchitis 1.1 1.3 1.6 -1.3 1.0
Medication for pain relief, constipation, heartburn 2.0 3.5 6.7 -2.6 0.5
Neck or shoulder pain in last month 1.1 1.6 2.4 -1.6 -0.9
Medication: Blood pressure 1.7 3.1 5.3 2.3 0.9
Angina (self-reported) 1.5 1.9 2.2 1.5 1.3
Migraine (self-reported) 1.8 2.2 3.8 -2.0 -0.7
Medication: Ibuprofen 1.9 2.3 4.6 2.2 0.0
Medication: Allopurinol 1.3 1.7 2.9 1.7 0.7
Medication: Omeprazole 5.9 7.0 7.9 2.8 2.5
Medication: Seretide 50 evohaler 0.2 0.3 0.4 0.6 -0.3
Mean time to correctly identify matches 0.5 1.0 2.0 -0.1 -1.4
Heart disease (mother) 1.1 1.4 1.4 -1.1 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.8 0.9 -0.1
Whole body fat mass 0.9 3.6 6.3 0.9 -2.5
Leg fat mass (right) 0.7 2.9 5.1 0.9 -2.2
Arm predicted mass (right) 1.1 5.4 8.1 -1.6 -2.9
Pulse rate, automated reading 0.4 1.4 1.8 1.0 1.4
Alcohol intake frequency. 0.4 1.0 1.9 -0.4 -1.4
Comparative height size at age 10 0.2 1.4 2.7 -0.1 -1.6
Number of full sisters 0.1 0.1 0.2 -0.5 -0.0
Suffer from ‘nerves’ 0.7 1.0 1.8 0.6 1.3
Overall health rating 0.0 0.0 0.1 -0.3 -0.1
Chest pain or discomfort 3.3 4.7 5.1 2.1 2.2
Had major operations 1.1 1.3 2.5 -1.6 0.3
Age at last live birth 3.8 5.5 10.1 1.0 3.2
Family relationship satisfaction 0.8 1.0 1.1 1.1 0.9
Leg pain on walking 0.7 0.9 1.6 -0.5 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.2 -0.5 -0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.4 -0.4 0.6
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.7 -1.6 -0.8
Medication: Aspirin 1.7 2.2 4.0 0.7 2.0
Supplements: Vitamin C 0.0 0.0 0.1 -0.2 -0.0
Knee pain experienced in last month 1.2 1.8 3.6 1.9 0.2
Hypertension (Self-reported) 0.1 0.4 0.6 0.8 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.0 1.0 0.4
Illnesses of father: Heart disease 0.8 1.1 1.3 1.1 1.0
Illnesses of siblings: Diabetes 0.9 1.2 2.2 0.4 1.5
Smoking status: Previous 2.7 4.1 7.8 0.6 2.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.1 0.6 -1.4
Whole body fat-free mass 0.6 3.5 6.5 -0.8 -2.5
Leg fat-free mass (right) 0.6 3.4 6.8 -0.1 -2.6
Arm fat percentage (left) 0.8 3.0 3.6 1.6 -1.9
Average weekly red wine intake 0.7 1.0 1.9 -0.3 1.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 -0.1 1.0
Mood swings 1.1 2.0 4.1 -0.0 -2.0
Loneliness, isolation 0.7 1.0 1.7 0.5 -1.3
Long-standing illness, disability or infirmity 0.9 1.4 1.9 1.4 1.0
Ever had bowel cancer screening 0.6 0.7 0.9 -0.7 -0.9
Diabetes diagnosed by doctor 1.0 1.7 3.4 1.9 0.1
Ever had stillbirth, spontaneous miscarriage or termination 2.3 2.5 4.9 2.2 -0.2
Friendships satisfaction 0.0 0.0 0.0 0.1 0.2
Qualifications: nursing, teaching 2.0 3.2 5.9 0.7 2.4
Commuting to job workplace: Walk 2.8 3.0 6.0 0.2 -2.4
Eye problems/disorders: Cataract 0.7 0.9 1.5 -1.2 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 -0.8 -0.0
Medication for cholesterol 0.1 0.1 0.2 -0.2 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.9 -0.2 -0.9
Back pain experienced in last month 0.9 1.3 2.0 -0.8 -1.4
Mineral and other dietary supplements 1.8 2.4 4.6 -2.1 0.5
Breast cancer (self-reported) 0.5 0.7 1.3 -1.1 -0.0
Asthma (self-reported) 1.2 2.4 4.5 0.4 -2.1
Osteoporosis (self-reported) 1.6 2.0 2.5 1.6 1.2
Osteoarthritis (self-reported) 3.1 4.0 7.3 -0.8 -2.7
Medication: Aspirin 0.7 0.9 1.7 0.1 1.3
Medication: Gliclazide 2.6 3.0 5.9 0.3 -2.4
Illnesses of father: None of the above (group 1) 0.4 0.6 1.1 -1.0 -0.2
Smoking status: Current 3.3 5.3 8.2 1.6 -2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.6 -1.3 -0.0
Whole body water mass 0.6 3.4 6.2 -0.8 -2.5
Leg predicted mass (right) 0.6 3.4 6.8 -0.1 -2.6
Arm fat mass (left) 0.7 2.9 4.9 1.0 -2.2
Number of self-reported non-cancer illnesses 0.5 0.8 1.2 1.1 0.7
Average weekly champagne plus white wine intake 1.7 2.3 4.1 -0.7 -2.0
Miserableness 0.4 0.6 1.2 0.3 -1.1
Guilty feelings 1.1 1.7 2.8 0.7 1.7
Wears glasses or contact lenses 2.0 2.3 4.4 -0.5 2.1
Ever taken oral contraceptive pill 0.6 0.7 1.2 0.4 1.1
Hearing aid user 1.4 1.6 2.1 1.4 -1.0
Mother’s age at death 0.4 0.5 0.9 -0.2 0.9
Financial situation satisfaction 0.3 0.4 0.7 0.8 -0.4
Tinnitus: Yes, now most or all of the time 2.8 3.2 4.8 -1.3 2.2
Commuting to job workplace: Public transport 1.0 1.2 1.3 1.2 1.0
Eye problems/disorders: Glaucoma 1.0 1.2 1.2 1.1 1.1
Medication: Blood pressure 0.3 0.6 0.8 0.6 -0.9
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 0.0 -0.0
Supplements: Fish oil (including cod liver oil) 2.7 3.5 3.6 1.8 -1.9
High cholesterol (Self-reported) 0.7 1.3 2.2 0.6 1.5
Medication: Bendroflumethiazide 0.3 0.5 1.0 0.1 -1.0
Medication: Paracetamol 2.3 3.5 5.8 1.1 -2.4
Medication: Lisinopril 0.1 0.2 0.2 0.3 0.5
Medication: Atorvastatin 0.7 0.9 1.3 1.1 0.7
Illnesses of father: High blood pressure 0.2 0.3 0.4 0.3 0.7
Alcohol drinker status: Never 0.8 0.9 1.1 -1.0 0.9
Ever smoked 1.1 2.0 3.3 1.8 0.9
Basal metabolic rate 0.7 3.6 7.1 -0.3 -2.7
Leg fat percentage (left) 0.8 3.0 4.1 1.4 -2.0
Arm fat-free mass (left) 0.6 3.0 5.3 -0.8 -2.3
Number of operations (self-reported) 1.8 2.6 5.2 -2.3 0.2
Average weekly beer plus cider intake 0.6 0.9 1.7 0.2 -1.3
Irritability 0.2 0.4 0.6 -0.4 -0.8
Risk taking 1.5 2.2 3.4 1.8 -1.0
Ever had prostate specific antigen (PSA) test 1.1 1.2 1.9 0.7 1.4
Fractured/broken bones in last 5 years 2.7 3.4 6.5 0.6 2.5
Age started oral contraceptive pill 0.9 1.1 2.2 -1.5 -0.1
Diastolic blood pressure, automated reading 0.0 0.0 0.0 -0.1 -0.1
Ever depressed for a whole week 5.0 6.2 11.0 1.2 3.3
Unable to work because of sickness or disability 0.1 0.1 0.1 -0.3 0.2
Commuting to job workplace: Cycle 0.5 0.6 1.1 0.2 1.0
Myopia 0.0 0.1 0.1 -0.3 0.2
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.6 -1.6 -0.6
Cholesterol lowering medication 0.5 0.8 1.5 1.2 0.2
Medication: Omeprazole (e.g. Zanprol) 4.6 5.6 7.0 2.6 2.1
Pain experienced in last month 1.1 1.8 2.5 1.1 1.6
Supplements: Calcium 1.8 2.0 3.6 0.6 1.9
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.4 -0.6
Heart attack/myocardial infarction (self-reported) 1.1 1.5 2.6 1.6 0.6
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 3.9 1.8 2.0
Heart disease (siblings) 2.6 3.2 4.5 1.4 -2.1
Alcohol drinker status: Previous 0.6 0.7 1.3 1.1 -0.4
Pack years of smoking 0.5 0.8 1.5 -1.2 -0.2
Impedance of whole body 0.2 1.1 2.2 1.5 0.2
Leg fat mass (left) 0.8 3.3 5.6 1.0 -2.4
Arm predicted mass (left) 0.5 2.6 4.5 -0.8 -2.1