TWAS hub - TIMD4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0330	0.0164	8.6e-03	0.012	0.007	0.016	0.007	0.009	5.7e-03	3.1e-02	1.6e-03	0.029	1.6e-02
2	TCGA	Breast Invasive Carcinoma	0.1187	0.0426	0.0e+00	0.126	0.112	0.120	NA	0.123	9.6e-25	5.2e-22	1.6e-23	NA	3.1e-24
3	TCGA	Colon Adenocarcinoma	0.1050	0.0720	2.6e-03	0.030	0.036	0.021	NA	0.033	7.1e-03	3.7e-03	2.0e-02	NA	5.0e-03
4	TCGA	Glioblastoma Multiforme	0.2580	0.1220	3.9e-04	0.176	0.089	0.121	NA	0.160	5.1e-06	1.2e-03	1.6e-04	NA	1.4e-05
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0251	0.0152	3.6e-03	0.016	0.020	0.007	NA	0.017	5.4e-03	2.3e-03	5.1e-02	NA	4.6e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.1385	0.0538	2.4e-12	0.108	0.109	0.096	NA	0.096	3.6e-12	3.1e-12	6.6e-11	NA	6.7e-11
7	TCGA	Brain Lower Grade Glioma	0.0851	0.0436	4.9e-07	0.037	0.059	0.063	NA	0.055	4.3e-05	2.6e-07	1.1e-07	NA	7.3e-07
8	TCGA	Lung Adenocarcinoma	0.0907	0.0570	2.5e-05	0.046	0.050	0.046	NA	0.039	4.3e-06	1.7e-06	3.9e-06	NA	1.9e-05
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.2770	0.0830	5.0e-15	0.258	0.237	0.258	NA	0.262	1.5e-17	4.5e-16	1.4e-17	NA	7.4e-18
10	TCGA	Prostate Adenocarcinoma	0.0319	0.0181	6.2e-03	0.020	0.026	0.018	NA	0.011	3.3e-03	8.6e-04	5.3e-03	NA	2.0e-02
11	TCGA	Soft Tissue Sarcoma	0.0830	0.0470	2.1e-03	0.062	0.027	0.035	NA	0.039	1.4e-04	9.0e-03	3.7e-03	NA	2.1e-03
12	TCGA	Stomach Adenocarcinoma	0.0590	0.0340	1.1e-03	0.010	0.035	0.020	NA	0.015	5.9e-02	1.4e-03	1.4e-02	NA	2.7e-02
13	TCGA	Testicular Germ Cell Tumors	0.1200	0.0610	5.5e-04	0.063	0.077	0.057	NA	0.046	3.0e-03	1.1e-03	4.5e-03	NA	9.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
LDL Cholesterol	33.8	53.5	95.6	-2.5	-9.8	-5.8	-9.7	-7.9	-1.3	-7.4	-8.4	-9.8	-8.0	-6.7	-7.8	-3.4
High cholesterol (Self-reported)	23.8	42.2	84.3	-1.6	-8.8	-4.7	-8.8	-5.9	0.0	-6.2	-6.7	-9.2	-8.8	-5.8	-7.4	-1.0
Triglycerides	15.4	25.2	44.6	-2.5	-6.5	-4.1	-6.4	-5.1	-0.8	-4.6	-5.6	-6.7	-6.0	-5.0	-5.6	-1.8
Medication: Cholesterol lowering	9.0	14.0	33.5	-0.7	-4.9	-3.1	-5.0	-3.1	0.2	-3.6	-3.1	-5.2	-5.8	-2.6	-4.7	-0.0
Medication: Simvastatin	8.7	12.8	27.9	-1.9	-4.6	-2.6	-4.6	-3.1	-0.5	-3.3	-3.5	-4.8	-5.3	-3.2	-4.3	-0.0
Cholesterol lowering medication	7.2	10.5	22.9	-1.3	-4.4	-2.1	-4.3	-2.8	-0.1	-2.9	-3.8	-4.8	-4.2	-3.3	-3.2	0.0
Crohns Disease (2012)	6.8	10.9	17.5	1.6	4.2	3.1	4.2	3.8	1.0	3.6	3.6	4.1	3.4	2.5	3.6	2.3
Neck or shoulder pain in last month	5.9	8.4	15.3	1.9	3.5	2.4	3.4	3.5	1.8	3.1	3.9	3.2	2.1	2.7	2.7	2.5
Wears glasses or contact lenses	5.7	6.6	13.1	-1.4	-2.5	-2.4	-2.3	-3.6	-3.1	-2.8	-3.2	-2.0	-0.7	-2.3	-2.0	-3.4
Blood Platelet Count	5.3	62.0	104.0	5.2	10.2	6.0	10.0	8.3	2.7	8.0	9.7	10.1	8.3	7.5	8.0	3.3
Crohns Disease (2017)	5.2	11.4	19.9	0.9	4.3	3.4	4.5	3.5	0.2	4.0	3.4	4.4	4.0	1.8	3.9	1.8
Cardiovascular Disease	5.0	16.6	35.5	-1.7	-5.5	-2.5	-5.4	-3.2	0.2	-3.3	-4.2	-6.0	-5.9	-4.1	-4.6	0.5
Pulse wave peak to peak time	4.5	5.2	12.7	2.3	2.4	1.7	2.2	2.6	2.5	2.1	3.6	2.1	1.2	2.8	1.8	1.6
Irritable Bowel Disease (IBD)	4.1	9.8	16.3	1.4	3.9	3.2	3.9	3.2	0.6	3.6	3.1	3.8	4.0	1.8	4.0	1.3
Medication: Atorvastatin	4.0	4.9	13.3	-0.5	-3.3	-0.8	-3.2	-1.9	0.7	-1.6	-2.4	-3.7	-2.7	-2.5	-1.9	-0.3
Knee pain experienced in last month	3.8	5.9	10.4	2.2	1.9	2.9	1.8	3.2	3.2	2.8	2.7	1.4	1.4	1.5	2.6	2.9
Chronotype (morning person)	3.6	8.3	15.3	2.6	2.7	2.9	2.5	3.9	3.5	3.2	3.2	2.0	1.2	2.1	2.8	3.8
Pulse wave Arterial Stiffness index	3.6	4.3	11.1	-2.3	-2.0	-1.4	-1.8	-2.3	-2.4	-1.8	-3.3	-1.7	-0.8	-2.6	-1.4	-1.5
Commuting to job workplace: Car/motor vehicle	3.5	4.0	7.8	-0.1	2.7	1.7	2.7	2.2	0.5	2.4	2.0	2.8	2.2	1.2	2.1	1.2
Type 2 Diabetes (T2D) (2012)	3.4	4.0	7.6	1.2	2.3	1.4	2.2	2.6	2.0	2.4	2.8	1.9	0.8	1.4	1.5	2.2
Hearing difficulty/problems: Yes	3.4	5.2	7.2	1.3	2.6	2.3	2.6	2.7	1.2	2.3	2.7	2.4	2.5	2.2	2.7	1.5
Bilateral oophorectomy (both ovaries removed)	3.3	3.8	8.9	-1.5	-1.2	-2.5	-1.2	-2.6	-3.0	-2.1	-2.3	-0.7	-1.0	-1.2	-2.3	-2.3
Ulcerative Colitis	3.2	4.6	6.8	1.2	2.6	2.1	2.6	2.2	1.1	2.3	2.6	2.5	2.4	1.7	2.6	1.0
Age at last live birth	3.2	4.6	8.3	-2.0	-2.3	-2.0	-2.2	-2.9	-2.2	-2.6	-2.6	-1.9	-0.7	-1.6	-1.6	-2.4
Medication for cholesterol	3.2	4.9	11.9	1.4	2.9	0.7	2.7	1.3	0.3	1.2	2.4	3.1	3.5	3.0	2.4	-1.0
Shortness of breath walking on level ground	3.0	3.6	6.9	0.2	-1.9	-2.4	-1.9	-2.3	-1.5	-2.4	-1.7	-1.6	-1.9	-0.8	-2.6	-1.8
Blood White Count	2.9	21.5	46.5	4.4	6.0	1.8	5.6	4.2	2.0	3.3	6.8	6.2	4.2	6.4	3.5	0.8
Medication for cholesterol, blood pressure or diabetes	2.8	4.7	16.8	0.2	2.8	1.1	2.8	1.1	-1.2	1.6	1.3	3.1	4.1	1.4	2.7	-1.3
Lupus	2.7	4.1	8.9	1.1	1.2	3.0	1.3	2.6	2.9	2.6	1.9	0.6	0.9	0.4	2.3	2.9
Number of children fathered	2.6	2.9	7.2	2.1	2.2	0.0	2.0	0.8	-0.2	0.5	1.6	2.5	2.4	2.7	1.3	-1.0
HbA1C	2.5	2.8	5.9	0.3	-2.4	-1.3	-2.4	-2.2	0.4	-2.0	-1.4	-2.4	-1.5	-0.8	-1.5	-1.2
Schizophrenia vs Biploar Disorder	2.3	3.0	5.0	1.1	1.8	1.8	1.7	2.2	2.0	2.1	1.9	1.4	1.1	1.2	1.7	2.0
Bipolar Disorder (2018)	2.2	3.4	6.0	0.8	-2.2	-2.4	-2.4	-2.1	0.1	-2.5	-1.1	-2.1	-2.1	-0.2	-2.3	-1.4
Stomach or abdominal pain in last month	2.2	2.7	5.1	1.2	1.9	1.6	1.8	1.7	1.7	2.1	2.2	1.6	1.4	1.1	1.6	0.9
Pulse wave reflection index	2.1	2.6	6.9	-1.2	-1.7	-1.3	-1.5	-1.8	-2.1	-1.5	-2.6	-1.4	-0.7	-1.9	-1.4	-1.2
Fasting Glucose	2.0	2.3	4.7	-1.0	-1.6	-1.7	-1.6	-2.2	-1.2	-2.0	-1.9	-1.3	-0.4	-0.7	-1.3	-1.9
Medication: Ramipril	2.0	2.6	4.6	-0.7	-1.9	-1.7	-1.9	-1.9	-1.3	-2.1	-1.3	-1.7	-1.5	-0.6	-1.8	-1.5
Medication: Lansoprazole	2.0	2.2	4.9	0.7	2.1	0.6	2.1	0.9	0.2	1.1	2.2	2.2	1.6	1.9	1.1	-0.6
Medication: Ventolin 100micrograms inhaler	2.0	2.5	7.0	-1.8	-0.7	-2.1	-0.7	-2.0	-2.4	-2.0	-1.4	-0.1	0.2	0.1	-1.2	-2.6
Illnesses of father: Heart disease	2.0	2.7	7.5	0.6	-2.3	-0.5	-2.3	-0.7	1.6	-1.1	-0.9	-2.7	-2.7	-0.9	-1.5	1.0
Alzheimer’s Disease (in father)	1.9	2.1	4.2	0.6	-1.3	-1.3	-1.3	-2.1	-1.5	-1.6	-1.5	-1.0	-1.1	-1.1	-1.8	-1.9
Financial difficulties in last 2 years	1.9	2.6	6.6	2.5	2.0	-0.1	1.7	1.5	1.1	0.8	2.3	2.0	0.7	2.6	0.5	0.5
Time employed in main current job	1.9	2.1	4.2	2.0	1.4	1.1	1.3	1.1	1.0	0.8	2.0	1.3	1.8	2.1	1.8	0.0
Medication: Seretide 50 evohaler	1.9	2.2	5.4	-2.0	-1.3	-1.4	-1.2	-2.2	-1.5	-1.4	-1.5	-1.0	-0.1	-0.9	-1.0	-2.3
Commuting to job workplace: Public transport	1.9	2.3	6.1	-0.1	-2.3	-0.7	-2.2	-1.4	0.3	-1.3	-1.5	-2.5	-1.7	-1.4	-1.3	-0.5
High blood pressure (mother)	1.8	2.5	5.8	-0.0	-2.3	-1.2	-2.4	-1.1	0.9	-1.7	-1.6	-2.4	-1.9	-0.7	-1.4	0.0
Length of working week for main job	1.8	1.9	3.8	1.2	1.3	1.9	1.3	1.9	1.0	1.4	1.6	1.2	0.6	0.8	1.4	1.8
Lung FEV1/FVC ratio	1.7	8.7	21.2	3.9	1.9	4.1	2.0	3.8	3.0	4.0	1.6	1.2	0.7	-0.8	2.8	4.6
Ever had hysterectomy (womb removed)	1.7	1.9	5.5	-1.1	-0.9	-1.7	-0.8	-1.5	-2.3	-1.4	-1.5	-0.4	-1.1	-1.0	-1.8	-1.1
Vitamin and mineral supplements	1.7	2.3	7.1	2.7	1.7	-0.2	1.6	0.7	0.0	0.5	1.7	1.8	1.8	2.3	0.9	-0.8
Heart attack	1.7	2.1	4.3	0.5	-1.7	-1.5	-1.8	-1.5	-0.4	-2.1	-1.2	-1.7	-1.9	-0.3	-1.7	-0.8
Comparative body size at age 10	1.7	4.7	8.3	-1.0	-2.7	-1.7	-2.5	-2.5	-1.5	-2.0	-2.9	-2.8	-1.8	-2.6	-1.9	-1.3
Medication: Omeprazole	1.7	2.0	8.6	2.7	0.9	-0.7	0.6	0.6	1.7	-0.0	1.9	0.8	0.9	2.9	0.4	-0.4
Verbal and Numeric Reasoning (VNR)	1.6	3.8	7.7	-0.1	-2.8	-1.3	-2.7	-2.0	-0.5	-2.2	-2.4	-2.8	-2.1	-1.7	-1.8	-0.6
Relative age of first facial hair	1.6	3.4	10.8	2.8	0.9	2.3	1.0	2.2	2.1	2.3	1.1	0.3	-0.1	-0.4	1.4	3.3
Qualifications: CSEs or equivalent	1.6	2.1	5.5	0.9	2.2	0.5	2.0	1.8	0.0	1.0	1.8	2.3	0.3	1.8	0.5	1.2
Chronic bronchitis/emphysema (father)	1.6	1.9	5.3	2.1	0.9	1.4	0.8	1.5	2.3	1.5	1.5	0.3	0.4	0.7	1.1	1.7
Illnesses of siblings	1.6	2.2	3.4	1.3	1.7	1.1	1.6	1.5	1.1	1.1	1.8	1.7	1.8	1.7	1.9	0.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.7	0.5	-1.0	-1.7	-1.1	-1.9	-1.6	-2.1	-1.0	-0.6	-0.2	0.3	-0.9	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.8	-0.3	-1.1	-1.9	-1.2	-1.8	-1.4	-1.7	-1.2	-0.9	-1.0	-0.5	-1.8	-1.9
Family relationship satisfaction	1.6	2.0	6.8	2.6	1.7	-0.6	1.5	0.3	-0.7	0.2	1.7	2.0	1.1	1.8	0.0	-1.3
Coronary Artery Disease (CAD)	1.5	1.8	3.6	-1.8	-1.4	-0.5	-1.3	-1.3	-1.7	-1.1	-1.8	-1.1	-0.4	-1.9	-0.8	-1.1
Blood Red Count	1.5	14.6	24.5	-3.0	-4.7	-3.4	-4.7	-3.9	-0.6	-3.7	-4.1	-5.0	-4.7	-3.3	-4.3	-1.3
Alcohol usually taken with meals	1.5	2.4	6.3	-2.5	-1.2	-0.5	-1.0	-1.6	-1.9	-0.9	-2.3	-1.1	-1.1	-2.3	-1.2	-0.6
Eye problems/disorders: None of the above	1.5	1.7	4.3	-0.0	-1.5	-1.4	-1.6	-1.3	-0.3	-1.4	-0.9	-1.5	-2.1	-0.9	-1.9	-0.4
Supplements: Fish oil (including cod liver oil)	1.5	1.9	3.8	-2.0	-1.6	-1.3	-1.6	-1.8	-0.6	-1.7	-1.6	-1.5	-1.0	-0.6	-1.2	-0.9
Age started oral contraceptive pill	1.5	1.9	6.6	-1.4	-1.5	-0.3	-1.4	-1.0	-0.8	-0.4	-2.3	-1.6	-1.1	-2.6	-0.8	0.3
Heart attack/myocardial infarction (self-reported)	1.5	2.0	4.1	0.5	-1.7	-1.5	-1.7	-1.5	-0.4	-2.0	-1.2	-1.7	-1.9	-0.3	-1.6	-0.7
Medication for hormone replacement therapy	1.4	1.5	3.3	-0.5	-1.3	-1.0	-1.3	-1.3	-0.7	-1.1	-1.3	-1.3	-1.8	-1.2	-1.8	-0.3
Average weekly fortified wine intake	1.4	1.6	4.5	-1.0	-0.7	-1.2	-0.7	-1.8	-2.1	-1.3	-1.7	-0.4	0.2	-0.8	-0.8	-1.9
Serious illness, injury or assault to yourself	1.4	1.7	4.1	0.9	1.2	1.4	1.2	2.0	1.4	1.6	1.4	0.9	0.3	0.6	1.0	2.0
Hearing difficulty/problems with background noise	1.4	2.3	5.4	-0.4	2.2	1.2	2.3	1.3	-0.7	1.7	1.6	2.3	1.6	0.9	1.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	4.5	0.2	-1.1	-2.1	-1.3	-1.5	-0.5	-2.1	-0.8	-1.0	-1.0	0.5	-1.3	-1.2
Asthma	1.4	2.7	6.5	-2.1	-0.4	-2.4	-0.5	-1.9	-2.6	-2.0	-0.9	0.2	-0.4	0.4	-1.8	-2.4
Number of full brothers	1.4	1.8	3.4	0.9	1.7	0.6	1.6	1.1	0.6	0.9	1.7	1.6	1.9	1.8	1.5	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.6	-1.7	-1.5	-0.9	-1.5	-0.9	-0.1	-1.0	-0.9	-1.6	-1.9	-1.1	-1.6	0.1
Supplements: Vitamin C	1.4	1.7	5.4	-0.4	-1.7	-0.8	-1.7	-0.6	0.5	-0.9	-0.8	-1.8	-2.3	-1.1	-1.7	0.7
Diabetes (father)	1.3	1.7	4.4	1.9	1.3	0.5	1.2	1.3	1.0	0.7	2.1	1.3	0.4	2.0	0.8	0.8
Migraine (self-reported)	1.3	1.7	3.0	-1.3	-1.7	-1.3	-1.7	-1.5	-0.2	-1.5	-1.0	-1.6	-1.0	-0.7	-1.1	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.4	-0.3	-1.1	-2.1	-1.3	-1.1	-0.3	-1.9	-0.7	-0.9	-1.2	0.5	-1.4	-1.1
Friendships satisfaction	1.3	1.6	3.9	1.5	1.9	0.1	1.7	1.1	0.0	1.0	1.6	2.0	0.9	1.4	0.5	0.0
Heart disease (siblings)	1.3	1.5	4.0	-1.3	-1.7	0.0	-1.6	-0.7	0.2	-0.4	-1.8	-2.0	-0.9	-1.9	-0.4	0.5
Ulcerative Colitis (UC)	1.2	2.3	6.0	0.9	1.8	1.4	1.8	1.2	0.2	1.4	1.4	1.8	2.5	1.0	2.2	-0.2
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.8	1.6	1.6	1.1	1.4	1.6	1.6	1.4	1.9	1.3	1.3	1.6	1.5	0.8
Angina	1.2	1.5	4.5	0.3	-1.2	-1.6	-1.3	-1.1	-0.3	-1.4	-0.7	-1.2	-2.1	-0.2	-2.1	-0.4
Lung cancer (father)	1.2	1.4	2.8	-1.4	1.2	1.4	1.3	1.2	0.3	1.7	0.4	1.1	1.3	-0.3	1.4	1.2
Health satisfaction	1.2	1.5	4.4	0.4	-0.9	-2.0	-0.9	-1.3	-1.1	-1.3	-0.7	-0.7	-1.6	-0.5	-2.1	-1.0
Angina (self-reported)	1.2	1.6	5.4	0.3	-1.4	-1.4	-1.4	-1.0	-0.0	-1.2	-0.7	-1.4	-2.3	-0.5	-2.1	-0.1
Had major operations	1.2	1.4	2.7	0.3	1.1	1.5	1.1	1.3	1.3	1.3	1.6	1.0	1.1	1.0	1.4	0.8
Hypertension (Self-reported)	1.2	3.2	8.9	-1.0	-2.3	-1.0	-2.2	-1.1	-0.3	-1.3	-1.6	-2.4	-3.0	-2.1	-2.2	0.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.9	-2.0	-1.2	-0.2	-0.9	-1.3	-1.1	-0.6	-1.7	-1.2	-0.6	-1.8	-0.8	-0.8
Asthma (self-reported)	1.2	2.5	5.3	-2.0	-0.6	-2.3	-0.7	-1.9	-2.3	-2.0	-1.1	-0.1	-0.6	0.2	-1.8	-2.1
Medication: Paracetamol	1.2	1.9	4.2	0.7	1.4	1.2	1.3	1.7	1.7	1.6	2.0	1.0	0.3	1.0	1.2	1.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	6.0	2.4	0.8	-0.6	0.5	0.5	1.6	0.1	1.7	0.7	0.5	2.4	0.1	-0.3
Pain experienced in last month	1.2	2.0	3.8	0.1	-1.5	-1.9	-1.5	-1.7	-1.3	-1.9	-1.3	-1.2	-1.3	-0.6	-1.7	-1.2
Current tobacco smoking	1.1	1.9	3.9	1.8	1.2	0.3	1.0	1.8	1.7	1.1	2.0	1.0	-0.2	1.7	0.6	1.8
Medication: Atenolol	1.1	1.4	5.0	0.3	-0.5	1.5	-0.4	0.8	1.2	1.4	-0.3	-1.2	-1.1	-1.8	0.4	2.2
Qualifications: None of the above	1.1	2.3	7.2	-0.5	0.7	2.2	0.8	2.0	1.7	2.3	0.8	0.1	0.3	-0.8	1.7	2.7
Illnesses of mother	1.1	1.4	3.5	0.5	1.7	0.2	1.6	1.0	0.1	1.0	1.9	1.7	1.1	1.4	0.7	-0.0
Birth weight of first child	1.1	1.9	7.6	-2.8	-1.1	-0.4	-0.9	-1.6	-1.6	-0.7	-1.9	-0.9	0.1	-1.6	-0.6	-1.5
Medication: Amlodipine	1.1	1.6	8.0	0.4	0.0	0.7	-0.1	1.5	2.1	0.6	0.9	-0.4	-2.0	0.2	-0.4	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.2	-1.8	1.4	1.2	1.6	0.8	-1.2	1.6	0.1	1.6	1.0	-1.1	0.8	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.3	1.2	1.5	0.7	1.4	1.1	0.8	1.0	1.2	1.5	1.4	1.4	0.9	0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.6	-0.8	1.0	1.7	1.1	0.8	0.2	1.4	0.9	1.0	1.9	0.1	1.8	0.1
Breast cancer (self-reported)	1.1	1.3	3.7	0.0	-1.5	0.3	-1.4	-0.5	1.1	-0.0	-1.1	-1.9	-1.5	-1.7	-0.6	0.9
Osteoporosis (self-reported)	1.1	1.4	2.5	1.3	1.0	1.5	1.0	1.2	1.2	1.3	1.2	0.8	1.3	0.7	1.6	0.8
Bipolar Disorder (2011)	1.0	1.0	2.2	-0.9	-1.0	-1.1	-1.0	-1.0	-0.9	-1.0	-0.9	-0.9	-1.4	-0.8	-1.5	-0.5
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.0	-0.7	1.0	1.8	1.2	1.5	0.6	1.9	0.3	0.6	-0.2	-1.0	0.7	2.0
Relative age voice broke	1.0	1.5	4.5	2.1	0.8	1.4	0.8	1.6	1.4	1.2	0.9	0.5	0.2	0.4	1.1	1.9
Multivitamins +/- minerals	1.0	1.3	2.9	-1.4	-1.5	0.7	-1.4	-0.1	0.9	-0.3	-1.2	-1.7	-1.3	-1.5	-0.3	1.2
Falls in the last year	1.0	1.3	2.8	1.7	1.4	0.8	1.3	1.1	0.8	1.1	1.5	1.3	0.8	1.1	0.8	0.6
Age at first live birth	1.0	1.8	7.3	-2.7	-0.9	-0.4	-0.7	-1.4	-2.2	-0.8	-1.9	-0.5	0.6	-1.5	-0.1	-1.3
Pulse rate, automated reading	1.0	3.2	12.4	3.3	1.5	-0.9	1.1	0.9	1.3	-0.1	2.6	1.6	1.3	3.5	0.8	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.7	-1.8	0.9	0.3	1.1	-0.4	-2.2	0.4	-0.3	1.3	1.5	-0.4	0.6	-0.8
Alzheimer’s Disease (including proxy)	0.9	1.3	3.3	-1.0	-1.2	-0.1	-1.1	-1.1	-0.7	-0.5	-1.6	-1.2	-1.2	-1.8	-1.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.4	-0.2	2.0	0.3	1.9	0.6	-0.7	1.0	1.3	2.1	1.2	0.9	0.6	-0.5
Emphysema/chronic bronchitis	0.9	1.0	3.6	-0.8	-1.2	-0.3	-1.1	-0.8	-0.0	-0.0	-1.2	-1.5	-1.1	-1.9	-0.8	0.4
Medication: Blood pressure	0.9	1.6	5.0	0.8	-1.3	-1.3	-1.5	-0.9	0.5	-1.5	-0.3	-1.4	-2.2	0.2	-1.9	-0.0
Smoking status: Previous	0.9	1.4	5.6	0.8	-0.5	-1.9	-0.7	-1.4	-0.3	-1.7	-0.2	-0.2	0.1	1.3	-1.0	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	7.0	0.4	-1.6	1.1	-1.4	-0.0	1.1	0.4	-1.6	-1.9	-1.5	-2.6	-0.3	1.5
Tinnitus: Yes, now most or all of the time	0.9	1.0	3.6	-0.6	0.6	1.9	0.8	1.2	0.6	1.4	0.5	0.5	0.8	-0.4	1.3	1.1
Average weekly beer plus cider intake	0.9	1.3	5.1	1.0	1.0	-0.4	0.9	0.1	-0.4	-0.5	1.5	1.5	1.3	2.3	0.5	-1.5
Irritability	0.9	1.5	3.6	1.5	1.6	0.3	1.5	1.1	0.6	1.0	1.9	1.6	0.4	1.6	0.3	0.5
Myopia	0.9	1.4	3.6	-0.1	-0.6	-1.2	-0.6	-1.8	-1.9	-1.0	-1.3	-0.4	-0.3	-1.2	-1.1	-1.9
Ovarian Cancer	0.8	1.1	3.6	0.7	1.2	0.0	1.1	0.3	-0.2	0.4	1.1	1.3	1.9	1.4	1.2	-0.9
Severe depression (siblings)	0.8	0.9	2.8	-0.3	-1.1	0.6	-1.1	0.2	1.7	0.3	-0.4	-1.4	-1.3	-0.9	-0.6	1.2
Maternal smoking around birth	0.8	1.1	5.3	2.3	0.7	0.2	0.5	0.9	1.1	0.1	1.6	0.7	-0.1	1.8	0.2	0.4
High blood pressure	0.8	2.3	6.7	-0.5	-2.0	-1.0	-1.9	-1.0	-0.0	-1.2	-1.2	-2.1	-2.6	-1.6	-1.9	0.4
Past tobacco smoking	0.8	1.5	5.0	-0.9	0.2	2.2	0.5	1.2	0.6	1.7	-0.2	-0.2	0.1	-1.6	1.2	2.2
Allergy	0.8	1.9	5.2	0.6	-0.2	2.3	-0.1	1.5	2.1	1.6	-0.0	-0.7	0.1	-1.1	1.5	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.5	1.5	0.8	0.9	0.7	0.7	1.6	1.0	1.4	0.7	0.6	0.9	0.6	0.1
Long-standing illness, disability or infirmity	0.8	1.3	5.9	1.9	1.0	-0.8	0.7	0.4	0.7	-0.3	1.7	1.1	0.4	2.4	0.1	-0.3
Back pain experienced in last month	0.8	1.1	2.1	-0.9	-1.3	-1.1	-1.3	-0.9	0.1	-0.9	-1.2	-1.5	-1.4	-0.9	-1.2	-0.1
Ever taken oral contraceptive pill	0.8	0.9	1.5	0.8	-1.0	-1.0	-1.0	-1.1	-0.2	-0.9	-1.0	-1.1	-1.0	-0.7	-1.2	-0.9
Financial situation satisfaction	0.8	1.0	3.1	0.5	1.3	-0.6	1.3	0.2	-1.7	0.0	0.6	1.8	1.0	1.0	-0.1	-1.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.0	-0.6	0.7	1.7	0.9	0.7	0.2	1.5	-0.1	0.6	1.4	-0.7	1.4	0.4
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	0.5	-1.0	-1.3	-1.1	-1.0	-0.2	-1.5	-0.4	-0.8	-1.0	0.2	-1.2	-0.8
Alcohol drinker status: Previous	0.8	0.9	3.1	-0.6	0.6	0.3	0.7	-0.6	-1.2	0.4	-0.7	0.8	1.8	-0.8	0.8	-1.7
Major Depression (MDD)	0.7	0.8	2.5	1.6	0.9	0.4	0.8	1.0	0.9	1.0	1.1	0.7	0.4	0.8	0.4	0.8
Medication: Metformin	0.7	0.9	1.8	1.3	1.0	0.7	0.8	0.9	1.4	0.9	1.2	0.7	0.8	1.1	0.9	0.5
Age when periods started (menarche)	0.7	1.6	8.9	3.0	0.8	0.4	0.6	1.0	1.7	0.4	1.6	0.6	0.4	1.6	0.9	0.7
Medication: Levothyroxine sodium	0.7	1.2	4.9	2.0	0.6	-0.2	0.3	0.9	1.2	-0.3	1.5	0.5	-0.2	2.2	0.3	0.9
Fluid intelligence score	0.7	1.4	2.6	0.8	-1.5	-1.1	-1.4	-1.5	-0.6	-1.6	-1.2	-1.3	-1.0	-0.6	-1.2	-1.1
Father’s age at death	0.7	0.9	4.2	-0.4	1.0	0.8	1.1	0.0	-0.3	0.9	0.1	1.1	2.0	0.0	1.4	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.5	-0.1	-0.2	-1.6	-0.2	-1.4	-1.6	-1.1	-0.7	0.1	-0.6	-0.1	-1.7	-1.9
Depression (self-reported)	0.7	0.8	3.0	0.3	-0.5	0.9	-0.4	0.4	1.7	0.9	0.1	-1.0	-1.1	-1.2	-0.2	1.3
Wheeze or whistling in the chest in last year	0.7	1.3	4.8	0.3	-0.7	-2.2	-0.9	-1.1	-0.8	-1.5	-0.4	-0.4	-1.3	0.4	-1.9	-0.9
Mean time to correctly identify matches	0.7	1.3	6.1	-1.7	0.0	1.1	0.4	-0.5	-1.8	0.8	-1.5	0.0	0.3	-2.5	0.2	-0.1
Heart disease (mother)	0.7	0.9	2.8	0.1	-1.3	0.1	-1.3	-0.4	1.4	-0.5	-0.4	-1.7	-1.3	-0.5	-0.5	0.6
Leg pain on walking	0.7	0.8	1.6	-1.0	-0.9	-1.1	-0.8	-1.0	-0.8	-0.8	-1.0	-0.8	-0.9	-0.8	-1.2	-0.6
Illnesses of siblings: Diabetes	0.7	0.8	3.0	-0.6	0.2	-1.4	0.2	-0.9	-1.7	-0.8	-0.4	0.5	-0.4	0.1	-1.3	-1.2
Eye problems/disorders: Cataract	0.7	0.9	3.9	1.5	0.6	0.1	0.4	0.8	0.9	-0.2	1.0	0.7	0.8	2.0	0.9	0.2
Smoking status: Current	0.7	1.1	3.0	1.3	0.8	0.1	0.6	1.5	1.4	0.8	1.5	0.5	-0.5	1.2	0.2	1.7
Average weekly champagne plus white wine intake	0.7	1.0	2.0	-1.4	-1.0	-1.0	-1.0	-1.1	-1.1	-1.2	-1.1	-0.7	-0.5	-0.5	-0.9	-1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	0.9	1.0	-0.1	0.9	1.1	0.6	0.6	1.6	0.8	-0.5	1.2	-0.1	1.4
Alcohol drinker status: Never	0.7	0.8	1.5	-1.2	-1.2	-0.7	-1.2	-0.7	0.2	-0.9	-0.7	-1.2	-1.1	-0.6	-0.8	-0.1
Ever smoked	0.7	1.2	4.2	0.8	0.1	-2.0	-0.1	-1.0	-0.6	-1.3	0.3	0.5	0.1	1.5	-1.0	-1.9
Fractured/broken bones in last 5 years	0.7	0.9	2.5	1.2	1.1	-0.3	0.9	0.2	-0.1	-0.0	0.8	1.3	1.2	1.6	0.4	-1.0
Ever depressed for a whole week	0.7	0.9	2.9	0.5	1.2	0.2	1.2	0.5	0.0	0.7	1.7	1.4	0.8	1.3	0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.4	0.9	1.8	0.9	1.7	0.9	0.4	1.0	1.3	1.9	2.3	1.6	1.7	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.5	3.9	1.3	-0.9	-2.0	-1.1	-1.3	0.1	-1.5	0.1	-0.9	-1.3	0.5	-1.9	-1.3
Depression (Nagel 2018)	0.6	0.9	2.3	-1.3	-0.9	0.0	-0.9	-0.0	0.3	0.0	-0.9	-1.2	-1.4	-1.5	-0.8	1.0
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.2	-0.5	-1.8	-0.7	-1.7	-1.7	-0.8	-1.5	-2.1	-1.8	-1.0	-1.4	-1.2	-0.9
Respiratory disease	0.6	1.3	3.9	-1.2	-0.3	-1.6	-0.4	-1.5	-1.6	-1.4	-0.9	0.0	0.3	0.3	-0.9	-2.0
Lung FVC	0.6	3.1	6.5	-0.5	-2.3	-0.8	-2.1	-1.7	-0.6	-1.3	-2.5	-2.4	-2.2	-2.6	-1.6	-0.1
Supplements: Zinc	0.6	0.6	2.0	-1.3	-0.6	-0.2	-0.5	-0.4	-0.2	0.1	-0.8	-0.7	-1.2	-1.4	-1.0	0.4
Had menopause	0.6	0.7	2.6	-0.3	-1.1	0.6	-0.9	-0.3	-0.0	-0.0	-1.3	-1.3	-0.5	-1.6	-0.0	0.7
Diabetes (self-reported)	0.6	0.9	1.6	0.7	1.2	0.6	1.1	1.0	0.7	0.8	1.3	1.1	0.9	1.3	0.8	0.5
Peak expiratory flow (PEF)	0.6	1.5	3.5	1.5	0.7	1.9	0.7	1.2	1.8	1.5	0.8	0.5	1.3	0.4	1.6	0.7
Medication: Allopurinol	0.6	0.9	1.9	0.0	-1.2	-0.8	-1.2	-1.1	-0.2	-0.7	-1.1	-1.4	-0.7	-1.2	-0.7	-0.6
Suffer from ‘nerves’	0.6	0.9	3.8	-1.9	-0.3	0.8	-0.1	0.1	-0.1	0.8	-0.8	-0.6	-0.7	-2.0	-0.2	1.0
Average weekly red wine intake	0.6	0.8	1.7	-0.4	-1.1	-0.5	-1.0	-1.3	-0.2	-0.6	-1.3	-1.1	-0.7	-1.2	-0.9	-0.8
Mineral and other dietary supplements	0.6	0.8	1.7	1.3	1.2	0.3	1.1	0.9	-0.1	0.8	1.1	1.3	0.9	0.9	0.6	-0.1
Number of self-reported non-cancer illnesses	0.6	1.0	4.4	-0.1	-1.1	-0.9	-1.2	-0.4	0.9	-0.8	-0.1	-1.3	-2.1	-0.2	-1.4	0.5
Eye problems/disorders: Glaucoma	0.6	0.7	3.3	-1.8	-0.2	0.1	-0.0	-0.5	-1.4	0.0	-1.2	-0.1	0.2	-1.4	-0.1	-0.2
Illnesses of father: High blood pressure	0.6	0.7	2.1	1.0	0.8	-0.4	0.7	0.0	0.1	0.1	1.1	1.0	1.0	1.4	0.3	-1.1
Diastolic blood pressure, automated reading	0.6	1.9	2.8	1.7	1.4	1.3	1.3	1.5	1.0	1.3	1.6	1.4	1.4	1.2	1.5	0.8
Supplements: Calcium	0.6	0.6	1.6	-0.0	-1.0	-0.3	-1.0	-0.6	0.4	-0.1	-1.0	-1.2	-1.0	-1.3	-0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.6	0.2	-0.9	-0.8	-1.0	-0.5	0.4	-0.5	-0.1	-1.1	-1.6	-0.4	-1.5	0.4
Pack years of smoking	0.6	0.9	2.2	-1.2	-1.1	-0.3	-1.0	-0.8	-0.4	-0.4	-1.4	-1.3	-1.0	-1.5	-0.9	-0.0
Rheumatoid Arthritis	0.5	0.7	2.4	0.1	1.1	-0.3	1.0	0.4	-0.4	0.2	1.3	1.3	0.7	1.5	0.1	-0.2
Neuroticism	0.5	1.1	3.9	-2.0	-1.1	-0.2	-1.0	-0.7	-0.4	-0.3	-1.2	-1.1	-1.1	-1.7	-1.0	-0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.6	0.6	1.2	-0.5	1.1	0.3	-0.1	0.4	1.3	1.2	0.8	1.2	0.2	-0.4
Townsend deprivation index at recruitment	0.5	0.7	4.6	0.7	-0.2	0.7	-0.3	0.8	2.1	0.4	0.5	-0.5	-0.1	0.5	0.7	1.1
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.0	0.5	0.7	-1.6	0.6	-0.7	-1.4	-1.1	0.6	1.1	0.6	1.7	-0.5	-1.7
Mouth/teeth dental problems	0.5	0.8	2.2	-1.1	-1.0	-0.7	-1.0	-1.1	-0.5	-1.0	-1.5	-0.9	-0.3	-0.7	-0.6	-0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	0.4	0.8	0.5	0.8	0.9	0.5	0.3	0.8	0.8	0.9	1.1	1.1	0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.9	-1.0	-0.6	-0.8	-0.5	-1.5	-1.4	-1.0	-1.3	-0.4	0.6	-0.6	-0.3	-1.7
Exposure to tobacco smoke at home	0.5	0.6	1.4	-0.6	1.2	-0.3	1.1	0.6	-0.4	0.6	1.0	1.1	-0.0	0.7	-0.1	0.5
Breastfed as a baby	0.5	0.6	2.0	-0.1	-0.7	-0.5	-0.6	-1.1	-0.6	-0.2	-0.9	-0.8	-0.8	-1.4	-0.9	-0.4
Loud music exposure frequency	0.5	0.6	1.4	-0.7	0.3	-1.0	0.3	-0.4	-1.1	-0.8	0.3	0.7	-0.1	1.0	-0.6	-1.2
Medication: Ibuprofen	0.5	0.6	1.5	1.2	0.7	0.6	0.6	0.8	1.1	0.4	1.2	0.6	-0.0	1.2	0.2	0.6
Mood swings	0.5	0.9	2.4	-0.7	1.3	1.2	1.4	1.0	0.1	1.6	0.7	1.2	0.4	-0.3	0.3	0.6
Loneliness, isolation	0.5	0.7	1.9	-0.2	0.9	0.9	1.0	1.1	0.0	1.2	0.6	0.8	-0.1	-0.2	0.3	1.4
Ever had bowel cancer screening	0.5	0.6	1.6	-0.4	0.9	0.7	1.0	0.9	-0.8	1.0	0.5	0.8	0.3	-0.3	0.6	1.2
Diabetes diagnosed by doctor	0.5	0.8	2.0	0.7	1.2	0.4	1.0	0.8	0.7	0.6	1.4	1.1	0.6	1.4	0.5	0.3
Medication: Gliclazide	0.5	0.6	1.1	-0.1	1.1	0.6	1.0	0.9	-0.0	0.7	0.7	1.0	0.8	0.6	0.9	0.7
Mother’s age at death	0.5	0.7	1.5	-0.3	-1.2	-0.5	-1.1	-0.6	-0.4	-0.6	-1.1	-1.2	-0.8	-1.0	-0.5	-0.0
Medication: Bendroflumethiazide	0.5	0.8	3.8	-1.9	-0.7	0.4	-0.6	0.1	-0.5	-0.0	-0.7	-0.8	-1.1	-1.3	-0.4	1.1
Medication: Lisinopril	0.5	0.6	2.9	-0.9	-0.1	0.8	-0.0	0.9	1.0	0.9	0.5	-0.5	-0.3	-0.5	0.7	1.7
Commuting to job workplace: Cycle	0.5	0.6	2.9	-0.5	-0.7	-0.5	-0.6	-1.2	-0.8	-0.6	-0.8	-0.6	0.6	-0.4	-0.1	-1.7
Age at First Birth	0.4	0.6	1.8	0.0	-1.2	-0.4	-1.2	-0.3	0.1	-0.8	-1.1	-1.4	-0.6	-1.0	-0.2	0.3
Primary Biliary Cirrhosis	0.4	0.5	1.3	0.7	-0.4	-1.1	-0.5	-0.2	0.3	-1.0	0.6	-0.5	-1.1	1.0	-0.9	-0.0
BMI	0.4	2.3	9.2	3.0	1.2	-0.1	0.9	0.8	1.5	0.0	1.9	1.1	1.2	2.7	0.8	-0.6
Waist Hip Ratio (WHR)	0.4	1.7	7.7	2.2	1.2	-1.2	0.9	0.7	0.4	-0.4	1.8	1.4	0.3	2.8	-0.2	-0.4
Smoking Status	0.4	1.1	4.3	1.4	-0.4	-2.1	-0.7	-0.3	0.5	-1.2	0.6	-0.3	-1.1	1.3	-1.3	-0.4
Allergy or Eczema	0.4	1.0	3.5	0.9	0.4	-1.5	0.3	-1.0	-1.1	-1.0	0.2	0.7	0.7	1.3	-0.4	-1.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	0.4	0.7	0.1	0.7	0.7	0.3	0.4	0.9	0.8	0.7	1.0	0.5	0.4
Diabetes (mother)	0.4	0.5	2.0	1.4	0.7	0.6	0.6	0.7	0.5	0.4	0.7	0.7	-0.0	0.7	0.2	0.8
Pack years adult smoking proportion	0.4	0.7	1.6	-0.6	-1.0	-0.4	-1.0	-0.6	0.2	-0.4	-1.0	-1.3	-1.1	-1.0	-0.9	0.1
Trunk fat percentage	0.4	1.7	11.5	3.4	0.7	-0.2	0.5	0.8	1.2	0.0	1.6	0.6	0.6	1.9	0.6	0.1
Fed-up feelings	0.4	0.7	2.5	0.2	1.4	0.0	1.4	0.6	-0.8	0.6	0.9	1.6	0.3	0.6	-0.0	-0.2
Arm fat percentage (right)	0.4	1.5	12.7	3.6	0.2	-1.0	-0.1	-0.1	0.6	-0.8	1.0	0.2	0.1	1.7	-0.2	-0.8
Pulse rate	0.4	0.7	3.1	1.5	0.2	-1.2	-0.1	0.1	0.8	-0.7	1.0	0.2	-0.3	1.8	-0.4	-0.3
Prospective memory result	0.4	0.5	1.7	0.1	-0.8	-0.5	-0.9	-0.0	1.3	-0.0	-0.2	-1.1	-1.0	-0.4	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	3.8	0.6	0.4	1.9	0.6	1.1	1.0	1.4	0.1	0.2	0.9	-0.7	1.7	1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.5	1.6	0.6	-0.5	0.4	0.0	0.3	-0.1	0.9	0.6	0.1	1.1	-0.2	-0.7
Blood clot in the leg (DVT)	0.4	0.5	2.0	0.2	-0.7	-0.8	-0.8	-0.3	0.3	-0.4	0.1	-0.8	-1.4	-0.2	-1.4	0.3
Glaucoma (self-reported)	0.4	0.5	1.3	-1.1	0.7	0.5	0.9	-0.2	-1.1	0.5	-0.4	0.9	0.9	-0.6	0.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.8	0.8	0.7	0.4	0.6	1.2	1.1	0.6	1.2	0.5	-0.3	0.9	0.6	1.7
Exposure to tobacco smoke outside home	0.4	0.5	1.9	-0.7	-0.2	-0.7	-0.2	-0.7	-0.9	-0.4	-0.2	-0.1	-1.2	-0.4	-1.4	-0.2
Qualifications: College or University degree	0.4	1.2	2.6	0.6	-1.4	-1.1	-1.5	-1.0	0.3	-1.3	-0.6	-1.6	-1.5	-0.3	-1.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.2	1.0	0.2	1.1	0.1	-1.1	0.5	0.1	1.1	1.2	-0.0	0.6	-0.5
Arm fat percentage (left)	0.4	1.8	15.1	3.9	0.2	-1.0	-0.0	0.1	0.8	-0.8	1.2	0.3	0.1	2.0	-0.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.2	-1.0	-0.2	-0.6	-0.1	-0.9	-1.5	-0.2	-0.6	0.1	-0.2	-1.0	-0.8	-1.0
Miserableness	0.4	0.6	2.5	-0.1	0.9	1.0	1.0	0.7	0.1	1.6	0.6	0.8	0.2	-0.6	0.2	0.7
Mean Putamen Volume	0.3	0.3	1.1	-0.5	-0.1	0.8	0.1	0.4	-0.4	0.4	-0.6	-0.0	-0.2	-0.9	0.1	1.0
Hypothyroidism (self reported)	0.3	0.7	2.6	0.8	0.5	-0.2	0.3	1.0	1.2	-0.0	1.3	0.4	-0.4	1.6	0.1	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.3	0.7	0.4	-1.1	0.2	-0.1	-0.3	-0.6	0.4	0.5	0.0	1.1	-0.4	-0.3
Systolic blood pressure, automated reading	0.3	0.9	3.7	-1.6	-0.6	0.6	-0.3	-0.1	-1.3	0.2	-1.3	-0.5	-0.4	-1.9	-0.0	0.7
Medication: Co-codamol	0.3	0.4	1.4	-0.7	-0.0	-0.6	0.0	-0.5	-1.2	0.1	-0.5	0.1	-0.3	-1.0	-0.8	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.6	0.2	0.3	0.2	0.5	0.9	0.8	0.4	-0.1	-1.0	-0.5	-0.7	0.9
Body mass index (BMI)	0.3	1.1	6.8	2.6	0.2	-0.6	-0.0	0.0	0.9	-0.6	1.0	0.2	0.7	1.8	0.2	-1.1
Trunk fat mass	0.3	1.2	8.0	2.8	0.4	-0.5	0.2	0.2	0.9	-0.4	1.1	0.3	0.6	1.8	0.4	-0.6
Waist circumference	0.3	1.1	6.3	2.5	0.3	-1.0	0.0	-0.2	0.4	-0.8	0.9	0.4	0.3	1.8	-0.2	-1.0
Nervous feelings	0.3	0.6	2.0	-1.4	-0.5	-0.4	-0.4	-0.5	-0.5	0.0	-0.7	-0.5	-0.9	-1.4	-0.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.5	-1.2	0.0	0.2	0.1	-0.1	-0.0	0.5	-0.0	-0.2	-1.2	-1.0	-0.9	0.6
Forced vital capacity (FVC)	0.3	1.0	3.0	0.2	-1.5	-0.4	-1.5	-1.1	0.7	-0.9	-1.1	-1.7	-0.7	-0.9	-0.4	-0.6
Neuroticism score	0.3	0.6	3.3	-1.8	0.2	0.3	0.3	0.2	-0.4	0.9	-0.2	0.1	-0.7	-1.3	-0.6	0.6
Alcohol intake versus 10 years previously	0.3	0.4	1.8	0.1	-0.5	0.1	-0.5	0.3	0.6	0.2	-0.0	-0.7	-1.3	-0.5	-0.8	1.0
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	-0.8	0.8	-0.1	0.8	0.0	-0.5	0.2	0.2	1.0	1.0	0.6	0.1	-0.8
Number of live births	0.3	0.4	2.1	0.1	0.5	-0.6	0.4	-0.1	0.1	-0.4	1.0	0.8	0.3	1.4	-0.3	-0.8
Happiness	0.3	0.3	0.8	-0.4	0.7	0.5	0.8	0.4	-0.6	0.9	0.2	0.7	-0.1	-0.6	-0.1	0.6
Arm fat mass (right)	0.3	1.3	8.1	2.8	0.5	-0.6	0.3	0.2	0.7	-0.5	1.2	0.5	0.8	2.0	0.4	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.2	-0.5	0.8	0.5	0.8	0.1	-0.9	0.1	-0.1	1.0	1.5	0.6	0.8	-0.5
Medication: Paracetamol	0.3	0.4	1.5	0.2	0.7	0.1	0.6	0.8	0.6	0.6	1.2	0.5	-0.3	0.6	0.3	1.1
Birth weight	0.3	0.6	2.5	-1.6	-0.6	-0.6	-0.5	-0.8	-0.5	-0.3	-0.9	-0.6	-0.3	-1.1	-0.5	-0.5
Worry too long after embarrassment	0.3	0.4	1.1	-0.2	1.0	-0.2	1.0	0.2	-0.2	0.5	1.0	1.0	0.6	0.7	0.2	-0.4
Number of full sisters	0.3	0.3	2.1	-0.2	0.0	-0.4	0.0	-1.0	-0.6	-0.2	-0.4	0.2	0.7	-0.1	-0.2	-1.5
Overall health rating	0.3	0.7	2.2	1.5	0.3	-1.2	0.1	0.2	0.5	-0.3	1.2	0.3	-0.9	1.2	-0.9	-0.1
Arm fat mass (left)	0.3	1.3	8.4	2.9	0.2	-0.8	0.0	-0.0	0.7	-0.8	1.0	0.3	0.6	1.9	0.2	-1.0
Guilty feelings	0.3	0.5	1.5	0.9	0.9	-0.3	0.7	0.4	0.3	0.1	0.9	1.0	0.3	1.2	-0.1	-0.3
Medication: Blood pressure	0.3	0.5	1.4	-0.6	-0.7	0.3	-0.6	0.2	-0.2	0.0	-0.6	-0.9	-1.2	-1.2	-0.4	1.2
Risk taking	0.3	0.5	1.9	0.8	0.2	-1.2	-0.1	-0.0	0.7	-0.4	0.8	0.1	-0.5	1.4	-0.8	-0.3
Depressed Affect (Nagel 2018)	0.2	0.4	1.8	-1.2	-0.1	0.2	-0.0	-0.1	-0.7	0.5	-0.7	-0.2	-0.7	-1.3	-0.6	0.5
Schizophrenia (2018)	0.2	0.4	1.1	1.0	0.6	-0.6	0.5	-0.1	0.1	0.1	1.0	0.6	-0.0	0.8	-0.6	-0.5
Worry (Nagel 2018)	0.2	0.4	1.1	-1.1	-0.5	-0.4	-0.4	-0.2	0.2	-0.0	-0.3	-0.5	-1.1	-0.7	-0.9	0.0
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	-0.8	-0.4	0.6	-0.4	0.2	0.3	0.2	-0.5	-0.5	-0.6	-0.7	-0.3	0.7
Reaction Time	0.2	0.5	1.0	-0.4	0.7	0.9	0.8	-0.1	-1.0	0.7	-0.3	0.7	0.8	-0.8	0.5	-0.4
Prostate Cancer	0.2	0.3	0.7	0.5	-0.7	-0.6	-0.7	-0.6	-0.0	-0.6	-0.7	-0.9	-0.5	-0.3	-0.4	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	2.2	-0.6	-0.2	-0.6	-0.2	-0.7	-0.4	-0.5	-0.2	0.1	0.3	0.0	-0.4	-1.5
Neuroticism (2016)	0.2	0.3	0.6	0.3	0.7	0.4	0.7	0.5	-0.1	0.5	0.5	0.8	0.5	0.5	0.3	-0.1
Systolic Blood Pressure	0.2	1.2	3.7	-1.8	-0.9	0.7	-0.7	0.1	-0.8	0.1	-1.2	-0.9	-1.2	-1.9	-0.5	1.4
Tanning	0.2	2.1	4.6	1.7	1.8	0.8	1.7	1.1	0.8	1.3	2.1	1.7	1.6	1.8	1.3	-0.0
Average weekly spirits intake	0.2	0.3	1.4	-1.2	0.3	0.4	0.4	0.5	-0.2	0.3	-0.3	0.3	0.7	0.2	0.6	0.3
Leg fat-free mass (left)	0.2	1.1	4.5	1.9	0.4	-0.5	0.1	-0.0	1.3	-0.5	1.2	0.3	0.7	2.1	0.3	-1.1
Hand grip strength (right)	0.2	0.4	2.2	-0.4	-0.0	-0.7	-0.0	-0.5	-1.0	-0.8	0.2	0.4	0.1	0.6	-0.6	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	1.0	0.2	0.4	1.0	0.5	0.5	0.8	0.8	0.3	0.4	0.8	0.1	0.8	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.0	0.4	0.7	0.4	0.6	0.5	0.8	0.1	0.2	0.2	-0.2	0.4	0.5
Supplements: Glucosamine	0.2	0.2	0.8	0.9	-0.5	-0.1	-0.5	-0.5	-0.2	-0.7	-0.5	-0.3	0.0	-0.0	-0.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.1	-1.0	-0.4	0.4	-0.3	0.1	0.1	0.6	-0.4	-0.5	-0.2	-1.1	0.1	0.6
Sitting height	0.2	1.1	2.5	-1.0	-0.7	-1.6	-0.9	-1.4	-0.4	-1.5	-0.7	-0.6	-0.7	0.4	-1.4	-1.4
Leg predicted mass (left)	0.2	1.0	4.2	1.9	0.3	-0.5	0.1	-0.0	1.3	-0.5	1.2	0.2	0.7	2.0	0.3	-1.1
Hair/balding pattern: Pattern 2	0.2	0.3	2.6	1.6	-0.2	-0.3	-0.3	0.0	0.5	-0.4	0.1	-0.4	-0.1	0.6	0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.1	0.4	0.1	0.4	0.1	-0.0	0.1	0.7	0.6	0.4	0.6	-0.1	-0.8
Pain all over the body in last month	0.2	0.2	0.5	-0.2	0.3	0.4	0.3	0.6	0.6	0.7	0.2	0.1	0.2	-0.3	0.5	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.9	1.4	-0.5	1.0	-0.4	0.3	1.4	0.5	-0.3	-0.8	0.0	-0.7	0.7	0.5
Noisy workplace	0.2	0.3	1.2	-1.1	0.2	0.1	0.4	-0.2	-1.0	0.4	-0.4	0.2	0.0	-1.0	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.2	1.0	-0.2	0.0	-0.3	0.2	1.1	-0.2	0.6	-0.3	-0.6	0.8	-0.3	0.2
Tense / ‘highly strung’	0.2	0.3	1.2	-1.1	0.8	0.1	0.7	0.5	-0.1	0.7	0.5	0.6	-0.2	0.1	-0.2	0.5
Hair/balding pattern: Pattern 4	0.2	0.4	1.0	-0.8	-0.1	-0.9	-0.2	-0.9	-0.7	-0.9	-0.1	0.1	-0.0	0.5	-0.4	-1.0
Headache pain in last month	0.2	0.4	2.6	-0.3	-0.6	-0.0	-0.7	-0.0	1.6	-0.1	0.2	-0.8	-0.8	0.2	-0.3	0.3
Gout (self-reported)	0.2	0.2	0.6	0.0	-0.6	-0.6	-0.7	-0.5	0.3	-0.4	-0.1	-0.8	-0.4	-0.2	-0.4	-0.3
Body fat percentage	0.2	0.9	7.8	2.8	0.2	-0.5	-0.0	0.3	0.8	-0.4	1.0	0.1	0.1	1.3	0.1	-0.2
Leg fat percentage (right)	0.2	0.6	3.7	1.9	-0.7	-0.8	-0.8	-0.3	0.5	-0.8	-0.0	-0.8	-0.8	0.3	-0.7	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	1.8	0.1	-0.2	0.8	-0.1	0.1	-0.3	0.5	-0.9	-0.3	0.5	-1.3	0.6	0.2
Whole body fat mass	0.2	1.0	7.1	2.7	0.3	-0.5	0.1	0.1	0.9	-0.4	1.1	0.3	0.5	1.6	0.3	-0.6
Comparative height size at age 10	0.2	1.2	9.8	-3.1	-0.7	0.7	-0.6	-0.3	-0.1	0.1	-1.1	-0.9	-0.2	-1.5	0.2	0.2
Chest pain or discomfort	0.2	0.2	1.3	1.1	0.2	-0.5	0.1	-0.1	0.6	0.1	0.4	0.2	-0.0	0.6	-0.4	-0.5
Medication: Aspirin	0.2	0.3	1.1	-0.3	-0.6	-0.2	-0.6	-0.1	0.3	-0.7	-0.2	-0.6	-1.0	0.1	-0.6	0.4
Leg fat-free mass (right)	0.2	1.0	3.9	1.8	0.3	-0.5	0.1	-0.2	1.0	-0.6	1.1	0.3	0.9	2.0	0.3	-1.5
Commuting to job workplace: Walk	0.2	0.2	0.9	0.9	0.2	0.1	0.2	-0.2	-0.3	-0.2	0.2	0.2	0.7	0.5	0.3	-0.7
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.8	-0.1	0.6	-0.1	0.3	0.7	0.8	0.2	-0.3	0.1	-0.4	0.4	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	1.4	-1.2	0.4	-0.0	0.4	0.2	-0.9	-0.0	-0.4	0.6	0.7	0.1	0.4	-0.0
Leg predicted mass (right)	0.2	1.0	3.8	1.8	0.3	-0.5	0.1	-0.2	1.0	-0.6	1.1	0.3	0.9	1.9	0.3	-1.4
Hearing aid user	0.2	0.3	0.8	-0.9	-0.7	-0.3	-0.6	-0.4	-0.3	-0.3	-0.6	-0.8	-0.4	-0.5	-0.3	0.1
Leg fat percentage (left)	0.2	0.7	4.0	2.0	-0.7	-0.9	-0.8	-0.5	0.3	-0.9	-0.1	-0.8	-0.6	0.2	-0.6	-0.6
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.4	-0.1	-0.9	-0.2	-0.5	-0.3	-0.4	0.1	0.0	-0.6	0.0	-0.9	-0.6
Leg fat mass (left)	0.2	0.6	3.9	2.0	-0.2	-0.9	-0.4	-0.4	0.4	-0.9	0.4	-0.2	0.1	1.0	-0.3	-1.0
Neuroticism (Nagel 2018)	0.1	0.2	0.9	-0.6	-0.1	-0.5	-0.2	-0.2	-0.0	0.2	0.1	-0.2	-0.9	-0.5	-1.0	0.0
HDL Cholesterol	0.1	0.2	0.7	0.9	-0.0	0.2	-0.2	0.5	0.8	-0.1	0.5	-0.1	-0.0	0.8	0.3	0.7
Schizophrenia (2014)	0.1	0.1	0.5	0.6	-0.0	-0.5	-0.0	-0.5	-0.2	0.1	0.0	-0.0	-0.2	-0.3	-0.7	-0.6
Blood Eosinophil Count	0.1	0.5	4.5	2.1	-0.5	0.1	-0.5	0.0	0.9	-0.2	-0.1	-0.6	-0.1	0.1	-0.1	0.3
Heel T-Score	0.1	1.0	4.2	2.1	0.8	0.4	0.7	0.4	1.0	0.6	1.0	0.6	1.4	1.4	1.0	-0.3
Hair Pigment	0.1	3.0	7.7	-0.3	1.6	2.3	1.8	2.4	0.9	2.4	1.6	1.4	0.8	0.1	1.8	2.8
Hand grip strength (left)	0.1	0.3	0.9	0.2	-0.4	-0.6	-0.5	-0.2	0.5	-0.6	0.4	-0.4	-1.0	0.5	-0.9	-0.3
Sensitivity / hurt feelings	0.1	0.1	0.6	-0.1	0.2	0.5	0.2	0.4	0.5	0.8	0.1	0.1	-0.0	-0.4	-0.1	0.3
Impedance of leg (right)	0.1	0.6	2.3	-1.5	0.3	0.6	0.4	0.5	-0.6	0.8	-0.3	0.2	-0.5	-1.1	-0.1	1.3
Taking other prescription medications	0.1	0.1	0.3	-0.2	0.1	-0.0	0.0	-0.3	0.6	0.4	0.3	-0.1	-0.3	-0.3	-0.3	-0.1
Impedance of leg (left)	0.1	0.5	2.0	-1.4	0.3	0.5	0.5	0.3	-1.0	0.7	-0.5	0.4	-0.1	-1.2	-0.0	0.8
Number of incorrect matches in round	0.1	0.2	1.0	1.0	0.4	-0.3	0.2	0.4	0.3	-0.2	0.0	0.4	-0.3	0.7	-0.2	0.7
Had other major operations	0.1	0.1	0.2	-0.3	0.4	0.4	0.4	0.3	-0.2	0.5	0.2	0.4	0.4	-0.0	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.1	-0.6	0.5	-0.5	-0.7	0.4	-0.0	-0.5	-0.6	0.2	-0.7	0.1	-0.7
Weight	0.1	0.7	3.1	1.8	-0.1	-0.8	-0.2	-0.5	0.6	-0.8	0.5	-0.0	0.6	1.4	0.0	-1.3
Impedance of arm (right)	0.1	0.2	1.4	1.2	0.2	-0.1	0.2	0.1	-0.4	0.2	0.1	0.2	-0.6	-0.3	-0.4	0.8
Trunk fat-free mass	0.1	0.7	4.4	-0.6	-0.2	-0.8	-0.2	-1.1	-0.2	-1.0	-0.2	0.0	0.9	0.8	-0.1	-2.1
Hip circumference	0.1	0.3	1.1	1.1	-0.3	-0.1	-0.3	-0.4	0.3	-0.5	0.2	-0.3	0.4	0.4	0.2	-0.9
Worrier / anxious feelings	0.1	0.2	0.5	-0.4	0.6	0.2	0.6	0.5	-0.1	0.4	0.5	0.7	0.4	0.3	0.3	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.3	0.4	0.3	0.4	0.6	0.4	0.3	0.8	0.3	0.5	0.7	0.6	0.1
Impedance of arm (left)	0.1	0.3	1.5	1.2	0.3	0.1	0.3	0.4	-0.1	0.4	0.2	0.3	-0.6	-0.2	-0.2	1.1
Trunk predicted mass	0.1	0.7	4.1	-0.7	-0.2	-0.7	-0.3	-1.0	-0.2	-1.0	-0.2	0.0	0.8	0.8	-0.1	-2.0
Ever highly irritable/argumentative for 2 days	0.1	0.2	1.0	-0.0	0.2	-0.5	0.1	0.3	0.3	-0.3	0.7	0.2	-0.2	1.0	-0.1	-0.1
High blood pressure (siblings)	0.1	0.1	0.6	-0.2	-0.1	-0.5	-0.1	-0.3	-0.4	-0.1	-0.0	-0.1	-0.4	-0.1	-0.8	-0.3
Arm fat-free mass (right)	0.1	0.4	2.0	-0.3	-0.1	-0.5	-0.2	-0.5	0.3	-0.7	0.1	-0.0	0.8	1.0	0.2	-1.4
Leg fat mass (right)	0.1	0.6	3.6	1.9	-0.2	-0.8	-0.4	-0.3	0.5	-0.8	0.4	-0.3	-0.0	1.0	-0.3	-0.8
Arm predicted mass (right)	0.1	0.4	2.4	-0.2	-0.3	-0.6	-0.4	-0.7	0.3	-0.9	-0.0	-0.2	0.7	0.9	0.0	-1.6
Alcohol intake frequency.	0.1	0.3	1.3	-1.2	0.2	0.7	0.3	0.3	0.1	0.7	-0.2	0.1	0.2	-0.7	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.5	0.7	0.3	0.0	0.2	0.0	0.2	-0.2	0.4	0.4	0.4	0.7	0.4	-0.1
Whole body fat-free mass	0.1	0.6	3.2	0.4	0.1	-0.7	-0.1	-0.6	0.4	-0.8	0.5	0.2	0.9	1.5	0.1	-1.8
Qualifications: nursing, teaching	0.1	0.1	0.5	-0.1	0.2	-0.1	0.1	0.0	0.2	-0.2	0.2	0.2	0.6	0.7	0.4	-0.3
Medication: Aspirin	0.1	0.2	0.5	-0.4	-0.4	0.4	-0.4	0.1	0.6	-0.3	-0.1	-0.5	-0.7	0.1	-0.2	0.6
Whole body water mass	0.1	0.6	3.3	0.3	0.0	-0.7	-0.1	-0.7	0.3	-0.9	0.3	0.1	0.9	1.4	0.1	-1.8
Basal metabolic rate	0.1	0.7	2.7	0.8	0.2	-0.7	0.0	-0.5	0.6	-0.8	0.6	0.2	0.9	1.6	0.2	-1.6
Arm fat-free mass (left)	0.1	0.5	2.7	-0.4	-0.3	-0.5	-0.3	-0.7	0.2	-0.9	-0.1	-0.2	0.8	0.9	0.1	-1.6
Impedance of whole body	0.1	0.3	1.5	-0.3	0.1	0.2	0.1	0.3	-0.5	0.5	-0.3	0.0	-0.7	-0.9	-0.3	1.2
Arm predicted mass (left)	0.1	0.5	2.7	-0.4	-0.2	-0.6	-0.3	-0.7	0.2	-0.8	0.0	-0.1	0.8	0.9	0.1	-1.6
Breast Cancer	0.0	0.1	0.2	-0.4	-0.2	-0.5	-0.3	-0.0	0.0	-0.3	-0.5	-0.3	-0.4	-0.1	-0.2	0.3
Height	0.0	0.6	2.4	-1.2	0.2	1.1	0.2	0.4	1.5	0.9	0.4	-0.1	0.8	0.1	1.0	0.6
Number of treatments/medications taken	0.0	0.1	0.3	-0.2	0.0	-0.0	-0.0	-0.1	0.3	-0.1	0.6	-0.0	-0.5	0.3	-0.4	0.1
Standing height	0.0	0.3	2.3	-1.5	-0.2	0.2	-0.1	-0.6	-0.3	0.0	-0.6	-0.2	0.2	-0.7	0.1	-0.4
Forced vital capacity (FVC), Best measure	0.0	0.2	0.5	-0.1	-0.4	0.6	-0.3	-0.0	0.6	0.0	-0.3	-0.5	0.3	-0.4	0.7	0.2
Number of operations (self-reported)	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2	-0.3	0.1	-0.2	-0.1	-0.2	-0.1	-0.0	-0.3	-0.3

Hub : Genes

TIMD4

Models

Trait associations