TWAS hub - TIMM23

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.188	0.080	0.0031	0.025	NA	0.040	NA	0.045	0.069	NA	2.8e-02	NA	2.2e-02
2	GTEx	Testis	0.227	0.079	0.0016	0.028	NA	0.099	NA	0.090	0.020	NA	3.8e-05	NA	8.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Neck or shoulder pain in last month	4.4	6.3	8.2	-2.9	-2.1
Bipolar Disorder (2018)	4.3	6.7	12.1	-1.2	3.5
Taking other prescription medications	4.1	6.4	6.9	-2.4	-2.6
Number of full sisters	4.1	5.0	9.4	-3.1	0.8
Wheeze or whistling in the chest in last year	4.0	7.0	7.5	-2.6	-2.7
Ever had bowel cancer screening	4.0	4.7	5.0	-2.2	-2.1
Qualifications: nursing, teaching	3.8	5.8	6.1	2.4	2.5
Financial difficulties in last 2 years	3.6	4.8	7.6	-2.8	-1.4
Ovarian Cancer	3.5	4.6	5.0	2.0	2.2
Length of working week for main job	3.5	3.8	4.6	-2.1	-1.7
Overall health rating	3.5	7.6	9.3	-3.1	-2.4
Illnesses of father: None of the above (group 1)	3.5	4.3	8.4	0.5	2.9
Prostate Cancer	3.4	4.8	8.1	1.2	2.8
Osteoarthritis (self-reported)	3.4	4.3	8.5	-2.9	-0.5
Heart disease (siblings)	3.3	4.0	4.4	-2.1	-1.9
Eye problems/disorders: Cataract	3.2	3.8	6.3	-2.5	-1.1
Alzheimer’s Disease (in father)	3.0	3.3	4.3	-2.1	-1.5
Medication: Lansoprazole	3.0	3.4	4.3	-2.1	-1.6
Severe depression (siblings)	2.7	3.0	3.8	-1.9	-1.5
Back pain experienced in last month	2.6	3.8	7.4	-2.7	-0.4
Pain experienced in last month	2.6	4.3	5.5	2.4	1.8
Diabetes (mother)	2.5	3.2	4.4	-1.4	-2.1
Peak expiratory flow (PEF)	2.5	5.9	11.6	-3.4	-0.4
Pulse wave Arterial Stiffness index	2.4	2.8	2.8	-1.6	-1.7
Illnesses of father: Heart disease	2.4	3.4	3.4	-1.8	-1.8
Hair/balding pattern: Pattern 3	2.3	3.5	4.9	-1.4	-2.2
Ever had prostate specific antigen (PSA) test	2.3	2.6	4.5	0.8	-2.1
Blood Red Count	2.1	20.4	38.3	-1.6	-6.2
Vitamin and mineral supplements	2.1	2.9	4.5	-1.1	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.7	7.6	-1.4	-2.7
Alzheimer’s Disease (including proxy)	2.0	2.9	4.7	-2.2	-1.1
Pack years adult smoking proportion	2.0	3.0	5.1	0.9	2.2
Friendships satisfaction	2.0	2.5	4.8	2.2	0.5
Medication: Co-codamol	1.9	2.2	3.5	-1.9	-0.9
Pulse wave peak to peak time	1.9	2.2	2.7	1.3	1.6
Age at First Birth	1.8	2.6	4.9	2.2	0.5
Family relationship satisfaction	1.8	2.2	2.8	1.7	1.2
Pack years of smoking	1.8	2.7	4.1	1.2	2.0
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.2	-2.0	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	4.5	-1.7	-2.1
Had other major operations	1.6	1.9	3.4	-0.7	-1.8
Pulse wave reflection index	1.6	2.0	2.9	-1.7	-1.0
Medication: Aspirin	1.6	2.1	4.3	-0.1	-2.1
Long-standing illness, disability or infirmity	1.6	2.5	2.9	-1.7	-1.4
Eye problems/disorders: Glaucoma	1.6	1.9	3.5	-0.6	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	2.4	-1.1	-1.5
Medication: Allopurinol	1.5	2.0	2.9	-1.7	1.0
Whole body fat mass	1.5	6.4	7.9	-2.2	-2.8
Eye problems/disorders: None of the above	1.4	1.7	2.2	1.5	1.1
Medication: Omeprazole	1.4	1.6	2.8	-1.7	0.7
Supplements: Vitamin C	1.4	1.6	2.2	1.5	1.0
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.3	0.2	-2.1
Medication: Atorvastatin	1.4	1.7	3.4	0.2	1.8
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.8	-0.3	-1.7
Trunk fat mass	1.3	5.8	7.2	-2.1	-2.7
Mouth/teeth dental problems: Dentures	1.3	2.2	4.2	-2.1	-0.4
Number of children fathered	1.3	1.5	2.1	-1.5	-1.0
Medication: Gliclazide	1.3	1.5	2.9	0.0	1.7
Commuting to job workplace: Cycle	1.3	1.6	3.0	0.5	1.7
Depressed Affect (Nagel 2018)	1.2	2.5	3.6	-1.9	-1.1
Primary Biliary Cirrhosis	1.2	1.7	2.1	-1.5	-1.1
Trunk fat percentage	1.2	4.8	6.9	-1.7	-2.6
Hand grip strength (right)	1.2	3.3	6.7	-2.6	0.1
Waist circumference	1.2	4.4	8.1	-0.8	-2.9
Hearing difficulty/problems with background noise	1.2	2.0	3.8	0.3	2.0
Weight	1.2	5.8	6.0	-2.5	-2.4
Hip circumference	1.2	5.0	6.9	-1.8	-2.6
Happiness	1.2	1.5	2.9	1.7	0.3
Body fat percentage	1.2	4.6	6.5	-1.7	-2.5
Leg fat mass (right)	1.2	4.7	5.9	-1.8	-2.4
Arm fat mass (left)	1.2	4.8	6.2	-1.9	-2.5
Fractured/broken bones in last 5 years	1.2	1.6	3.1	1.7	-0.4
Cholesterol lowering medication	1.2	1.8	3.4	0.4	1.9
Leg fat mass (left)	1.2	4.8	5.6	-2.0	-2.4
Neuroticism (Nagel 2018)	1.1	2.5	3.3	-1.8	-1.3
Ever had hysterectomy (womb removed)	1.1	1.2	2.3	-1.5	0.4
Medication: Atenolol	1.1	1.4	2.3	-1.5	-0.7
Hair/balding pattern: Pattern 2	1.1	1.5	2.6	0.5	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.0	0.8	1.4
Illnesses of mother	1.1	1.4	2.0	1.4	0.9
Breastfed as a baby	1.1	1.4	2.1	1.4	0.8
Qualifications: College or University degree	1.1	3.4	4.9	2.2	1.4
Unable to work because of sickness or disability	1.1	1.4	2.3	-0.7	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.6	-1.6	-0.7
Falls in the last year	1.0	1.4	2.3	-0.6	-1.5
Leg fat percentage (right)	1.0	3.6	4.9	-1.5	-2.2
Medication: Blood pressure	1.0	1.7	3.3	0.4	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.3	-1.5	-0.4
Medication: Aspirin	1.0	1.3	2.5	0.4	-1.6
Miserableness	1.0	1.7	2.5	-0.9	1.6
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.1	0.4	-1.4
Leg fat percentage (left)	1.0	3.7	4.2	-1.8	-2.0
Arm fat-free mass (left)	1.0	4.9	7.7	-2.8	-1.4
Blood White Count	0.9	6.3	10.4	-1.5	-3.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.3	-0.3	1.5
Leg fat-free mass (left)	0.9	4.7	5.2	-2.3	-2.1
Multivitamins +/- minerals	0.9	1.1	1.3	1.2	0.9
Supplements: Glucosamine	0.9	1.1	2.3	1.5	0.1
Body mass index (BMI)	0.9	3.7	5.3	-1.4	-2.3
Leg predicted mass (left)	0.9	4.5	4.9	-2.2	-2.0
Number of live births	0.9	1.2	2.1	1.4	0.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	6.2	-2.5	-0.3
Arm fat mass (right)	0.9	3.8	4.4	-1.8	-2.1
Tense / ‘highly strung’	0.9	1.5	2.2	1.5	0.8
Glaucoma (self-reported)	0.9	1.1	1.9	-0.5	-1.4
Arm predicted mass (right)	0.9	4.6	7.2	-2.7	-1.4
Smoking status: Previous	0.9	1.3	1.3	1.1	1.1
Leg fat-free mass (right)	0.9	4.6	6.0	-2.5	-1.8
Arm fat percentage (left)	0.9	3.7	5.5	-1.4	-2.3
Leg predicted mass (right)	0.9	4.5	5.7	-2.4	-1.8
Ever depressed for a whole week	0.9	1.1	2.1	0.4	-1.5
Arm predicted mass (left)	0.9	4.7	7.3	-2.7	-1.4
Height	0.8	15.2	28.5	-5.3	-1.4
Neuroticism	0.8	2.0	2.2	-1.5	-1.3
Number of treatments/medications taken	0.8	1.5	2.7	-1.6	-0.5
Chronic bronchitis/emphysema (father)	0.8	1.0	1.6	0.6	-1.2
Had menopause	0.8	1.0	1.4	-0.8	-1.2
Heart attack	0.8	1.0	1.0	-0.9	-1.0
Worrier / anxious feelings	0.8	1.5	1.6	-1.2	1.3
Noisy workplace	0.8	0.9	1.1	1.0	0.9
Lung cancer (father)	0.8	0.9	1.2	-1.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.2	-1.5	0.5
Gout (self-reported)	0.8	1.1	1.9	-0.6	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.4	-0.8	1.2
Arm fat-free mass (right)	0.8	4.1	6.2	-2.5	-1.4
Had major operations	0.8	0.9	1.7	-1.3	-0.4
Knee pain experienced in last month	0.8	1.3	2.5	-1.6	0.0
Medication for cholesterol	0.8	1.1	1.9	-0.6	-1.4
High cholesterol (Self-reported)	0.8	1.4	1.4	-1.2	1.2
Number of operations (self-reported)	0.8	1.2	1.4	-1.2	-1.0
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.1	-1.1	-1.0
LDL Cholesterol	0.7	1.1	2.1	1.5	0.2
Lung FEV1/FVC ratio	0.7	3.4	6.8	-2.6	0.1
Hand grip strength (left)	0.7	1.9	2.3	-1.5	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.0	-1.0	-0.9
Systolic blood pressure, automated reading	0.7	2.0	3.7	-0.5	-1.9
Medication for hormone replacement therapy	0.7	0.8	1.1	-0.7	-1.0
Medication: Simvastatin	0.7	1.0	1.5	-1.2	-0.7
Arm fat percentage (right)	0.7	2.8	4.3	-1.1	-2.1
Alcohol intake versus 10 years previously	0.7	1.1	2.1	-1.4	0.3
Medication: Amlodipine	0.7	1.0	1.9	0.2	-1.4
Migraine (self-reported)	0.7	0.9	1.2	-1.1	0.7
Comparative height size at age 10	0.7	3.7	7.4	-2.7	-0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.1	1.1	0.8
Diabetes diagnosed by doctor	0.7	1.2	2.2	1.5	-0.3
Illnesses of father: High blood pressure	0.7	0.9	1.7	0.2	1.3
Basal metabolic rate	0.7	4.1	5.8	-2.4	-1.6
Basal cell carcinoma (self-reported)	0.7	0.9	1.2	0.7	1.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	-1.1	-0.3
HbA1C	0.6	0.7	0.8	0.9	0.7
Lupus	0.6	1.0	1.1	-1.1	0.9
Supplements: Zinc	0.6	0.6	1.2	1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.4	1.2	-0.4
Diabetes (self-reported)	0.6	1.0	1.8	1.3	0.4
Father’s age at death	0.6	0.8	1.2	1.1	0.7
Headache pain in last month	0.6	1.1	1.4	-0.8	-1.2
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.2	-0.3	-1.1
Shortness of breath walking on level ground	0.6	0.7	1.4	1.2	0.0
Mean time to correctly identify matches	0.6	1.2	1.3	-1.1	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	-1.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.3	-1.1	-0.1
Whole body fat-free mass	0.6	3.6	5.5	-2.3	-1.3
Whole body water mass	0.6	3.7	5.5	-2.4	-1.4
Alcohol drinker status: Previous	0.6	0.7	1.2	1.1	0.3
Schizophrenia (2018)	0.5	1.1	2.2	0.0	-1.5
HDL Cholesterol	0.5	0.8	1.5	-0.2	-1.2
Allergy or Eczema	0.5	1.3	1.8	-1.3	1.0
Relative age of first facial hair	0.5	1.0	2.0	0.2	-1.4
Average weekly fortified wine intake	0.5	0.6	0.8	0.6	0.9
Relative age voice broke	0.5	0.8	1.4	-0.4	-1.2
Nervous feelings	0.5	0.9	1.4	1.2	0.6
Mouth/teeth dental problems	0.5	0.8	1.6	0.2	1.3
Illnesses of siblings	0.5	0.7	1.1	0.5	1.0
High blood pressure (siblings)	0.5	0.7	1.2	-0.3	-1.1
Number of full brothers	0.5	0.7	1.2	-1.1	0.3
Medication: Ibuprofen	0.5	0.6	0.7	0.7	0.8
Osteoporosis (self-reported)	0.5	0.6	1.1	-0.3	-1.0
Number of self-reported non-cancer illnesses	0.5	0.8	1.2	-1.1	-0.6
Hearing aid user	0.5	0.6	1.0	-1.0	-0.4
Medication: Lisinopril	0.5	0.7	1.2	-0.5	1.1
Irritability	0.5	0.9	1.7	-1.3	0.2
Depression (Nagel 2018)	0.4	0.6	0.9	-0.9	-0.5
Worry (Nagel 2018)	0.4	0.8	1.6	-1.2	-0.2
Breast Cancer	0.4	1.1	1.3	0.9	-1.1
Body Mass Index (BMI) (2010)	0.4	0.6	0.7	-0.8	0.7
Crohns Disease (2012)	0.4	0.7	0.9	0.7	1.0
Mean Putamen Volume	0.4	0.5	0.8	0.9	0.3
Fasting Glucose	0.4	0.5	0.9	-1.0	0.4
Schizophrenia (2014)	0.4	0.9	1.2	-1.1	-0.8
Blood Eosinophil Count	0.4	2.9	5.8	-0.2	-2.4
BMI	0.4	2.1	2.9	-1.7	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	0.8	0.9	0.8
Angina	0.4	0.5	0.8	-0.9	-0.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.2	-0.8	1.1
Medication: Levothyroxine sodium	0.4	0.7	1.2	-1.1	0.3
Past tobacco smoking	0.4	0.7	1.1	-0.5	-1.0
Forced vital capacity (FVC)	0.4	1.6	3.1	-1.8	0.4
Trunk fat-free mass	0.4	2.6	4.8	-2.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.3	1.1	0.7
Medication: Cholesterol lowering	0.4	0.7	0.8	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.5	-1.6	-0.5
Trunk predicted mass	0.4	2.6	4.8	-2.2	-0.6
Worry too long after embarrassment	0.4	0.7	0.7	-0.8	0.8
Pulse rate, automated reading	0.4	1.4	2.9	0.1	-1.7
Commuting to job workplace: Walk	0.4	0.4	0.6	-0.8	-0.5
Medication: Blood pressure	0.4	0.7	0.8	0.9	0.8
Ever smoked	0.4	0.7	1.1	0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.9	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	0.7	-0.8	0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	-0.8	0.0
Waist Hip Ratio (WHR)	0.3	1.3	2.6	1.6	0.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	0.9	0.3
Medication: Metformin	0.3	0.4	0.7	0.8	0.3
Impedance of leg (right)	0.3	1.6	1.7	1.2	1.3
Maternal smoking around birth	0.3	0.4	0.4	-0.7	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	0.7	-0.3
Qualifications: CSEs or equivalent	0.3	0.4	0.5	-0.6	-0.7
Serious illness, injury or assault to yourself	0.3	0.3	0.6	-0.2	-0.8
Sitting height	0.3	2.3	4.4	-2.1	-0.4
Impedance of leg (left)	0.3	1.5	2.3	0.8	1.5
Alcohol usually taken with meals	0.3	0.5	1.0	1.0	0.2
Pain all over the body in last month	0.3	0.3	0.5	0.7	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.4	0.8
Impedance of arm (right)	0.3	1.4	2.6	1.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.1	0.9
Asthma	0.3	0.6	0.9	-1.0	-0.5
Prospective memory result	0.3	0.3	0.6	0.2	-0.8
Standing height	0.3	2.7	5.3	-2.3	-0.1
Medication: Paracetamol	0.3	0.5	1.0	-1.0	0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.1	1.0
Birth weight	0.3	0.5	1.0	-1.0	0.3
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.1	-0.8
Angina (self-reported)	0.3	0.4	0.6	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	0.7	-0.9	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.3
Asthma (self-reported)	0.3	0.5	0.8	-0.9	-0.6
Wears glasses or contact lenses	0.3	0.4	0.7	-0.3	-0.8
Financial situation satisfaction	0.3	0.3	0.6	0.3	0.8
Medication: Paracetamol	0.3	0.4	0.5	-0.7	0.5
Diastolic blood pressure, automated reading	0.3	0.9	1.7	0.3	-1.3
Supplements: Calcium	0.3	0.4	0.6	0.8	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	-0.9	-0.5
Reaction Time	0.2	0.3	0.4	-0.6	-0.5
Neuroticism (2016)	0.2	0.3	0.5	-0.7	0.3
Triglycerides	0.2	0.4	0.7	-0.2	0.9
Heel T-Score	0.2	1.2	2.4	0.3	-1.5
Hypothyroidism (self reported)	0.2	0.4	0.6	0.5	0.8
Respiratory disease	0.2	0.4	0.7	-0.9	-0.1
Chronotype (morning person)	0.2	0.5	0.5	0.7	0.6
Average weekly spirits intake	0.2	0.2	0.4	-0.6	0.0
Hearing difficulty/problems: Yes	0.2	0.2	0.3	-0.4	0.6
Diabetes (father)	0.2	0.2	0.4	0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.7	0.1
High blood pressure	0.2	0.6	0.8	0.9	-0.6
High blood pressure (mother)	0.2	0.2	0.4	0.6	-0.2
Number of incorrect matches in round	0.2	0.3	0.4	-0.7	0.5
Allergy	0.2	0.4	0.6	0.8	-0.4
Fluid intelligence score	0.2	0.5	0.8	-0.4	-0.9
Time employed in main current job	0.2	0.2	0.5	0.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	-0.9	0.0
Pulse rate	0.2	0.4	0.6	0.4	-0.8
Depression (self-reported)	0.2	0.2	0.3	-0.5	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	0.0	-0.6
Blood clot in the leg (DVT)	0.2	0.2	0.4	0.2	-0.6
Age at first live birth	0.2	0.3	0.6	0.8	-0.1
Health satisfaction	0.2	0.3	0.5	0.7	0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.2	0.7
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.6	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.3	0.5	0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.7	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.4	-0.6
Hypertension (Self-reported)	0.2	0.7	1.1	1.1	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.5	-0.4
Loneliness, isolation	0.2	0.3	0.5	-0.7	-0.4
Breast cancer (self-reported)	0.2	0.2	0.3	0.5	-0.4
Guilty feelings	0.2	0.2	0.4	-0.6	-0.4
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	0.2
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.7	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.6	-0.6	0.8
Impedance of whole body	0.2	0.8	0.9	1.0	0.8
Crohns Disease (2017)	0.1	0.2	0.3	-0.5	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	-0.6	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.6	-0.4
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	-0.2	0.5
Smoking Status	0.1	0.4	0.7	0.8	0.2
Cardiovascular Disease	0.1	0.4	0.6	0.4	0.8
Lung FVC	0.1	0.3	0.6	-0.1	0.8
Hair Pigment	0.1	2.8	5.6	0.3	-2.4
Tanning	0.1	1.1	1.2	1.1	1.0
Sensitivity / hurt feelings	0.1	0.1	0.1	0.3	-0.3
Townsend deprivation index at recruitment	0.1	0.1	0.1	-0.3	0.2
Fed-up feelings	0.1	0.1	0.1	-0.4	0.2
Age when periods started (menarche)	0.1	0.2	0.3	-0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.2	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.0	0.4
Medication: Ramipril	0.1	0.1	0.1	0.4	-0.2
Neuroticism score	0.1	0.1	0.2	-0.5	0.1
Impedance of arm (left)	0.1	0.5	0.9	0.9	0.4
Hair/balding pattern: Pattern 4	0.1	0.1	0.3	-0.1	-0.5
Birth weight of first child	0.1	0.2	0.3	0.6	-0.1
Loud music exposure frequency	0.1	0.2	0.2	0.5	0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.1	-0.6
Heart disease (mother)	0.1	0.1	0.1	0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	-0.6	0.1
Alcohol intake frequency.	0.1	0.2	0.3	-0.5	0.3
Suffer from ‘nerves’	0.1	0.1	0.2	0.5	-0.2
Chest pain or discomfort	0.1	0.1	0.2	0.1	-0.5
Age at last live birth	0.1	0.1	0.2	0.5	0.0
Leg pain on walking	0.1	0.1	0.2	0.1	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.0	0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.2	0.4	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.2
Mother’s age at death	0.1	0.1	0.2	0.5	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.4	0.1
Risk taking	0.1	0.1	0.1	0.4	-0.3
Age started oral contraceptive pill	0.1	0.1	0.1	0.3	-0.3
Myopia	0.1	0.2	0.3	0.6	0.3
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.2	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.1	0.1
Blood Platelet Count	0.0	0.1	0.2	0.4	-0.0
Systolic Blood Pressure	0.0	0.0	0.0	-0.1	0.0
Current tobacco smoking	0.0	0.0	0.1	-0.0	0.3
Qualifications: None of the above	0.0	0.1	0.1	-0.3	0.2
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.0	-0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.3	0.2
Comparative body size at age 10	0.0	0.0	0.0	0.1	-0.1
Average weekly red wine intake	0.0	0.0	0.0	-0.1	0.1
Mood swings	0.0	0.1	0.1	-0.3	-0.2
Mineral and other dietary supplements	0.0	0.0	0.1	0.0	-0.3
Smoking status: Current	0.0	0.1	0.1	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	-0.2	0.4
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	-0.1	-0.1
Alcohol drinker status: Never	0.0	0.0	0.0	0.2	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.2	-0.1

Hub : Genes

TIMM23

Models

Trait associations