TWAS hub - TK1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.367	0.111	0.00580	0.265	NA	0.210	NA	0.182	9.4e-08	NA	2.6e-06	NA	1.3e-05
2	GTEx	Brain Putamen basal ganglia	0.599	0.128	0.00079	0.180	NA	0.025	NA	0.151	4.7e-05	NA	8.6e-02	NA	2.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Family relationship satisfaction	8.3	10.2	10.7	-3.3	-3.1
Number of full brothers	5.5	6.9	8.6	2.3	2.9
Taking other prescription medications	5.4	8.3	9.9	3.1	2.6
Illnesses of siblings: Diabetes	5.4	6.6	6.9	2.5	2.6
Exposure to tobacco smoke outside home	5.2	7.0	8.7	-2.3	-3.0
Medication: Lansoprazole	3.5	4.0	4.2	2.0	2.0
High blood pressure (mother)	3.4	4.7	5.5	-2.3	-2.0
Length of working week for main job	3.3	3.7	4.0	-1.8	-2.0
HbA1C	3.1	3.5	3.9	-2.0	-1.7
Gout (self-reported)	3.0	4.1	6.2	1.4	2.5
Blood White Count	2.8	20.4	30.4	-3.2	-5.5
Multivitamins +/- minerals	2.8	3.5	5.6	-1.2	-2.4
Medication: Seretide 50 evohaler	2.8	3.2	3.3	1.8	1.8
Eye problems/disorders: None of the above	2.6	3.1	4.5	-2.1	-1.3
Emphysema/chronic bronchitis	2.6	2.9	3.8	1.9	1.4
Pain type(s) experienced in last month: Hip pain	2.6	3.3	4.5	2.1	1.4
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	3.4	1.8	1.8
Alcohol drinker status: Previous	2.5	2.8	3.3	1.8	1.5
Alcohol drinker status: Never	2.4	2.8	3.2	-1.8	-1.6
Migraine (self-reported)	2.3	2.8	3.6	1.9	1.4
Blood clot in the leg (DVT)	2.2	2.9	2.9	1.7	1.7
Number of incorrect matches in round	2.1	3.5	4.1	-2.0	-1.7
Friendships satisfaction	2.1	2.6	3.9	-1.1	-2.0
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	3.2	-1.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	4.6	2.2	1.4
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	2.6	-1.6	-1.6
Average weekly beer plus cider intake	2.0	2.9	5.2	-2.3	-0.8
Myopia	2.0	2.8	3.4	-1.5	-1.8
Medication for hormone replacement therapy	1.9	2.1	3.4	-1.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.2	5.7	1.6	2.4
Supplements: Glucosamine	1.8	2.3	2.9	-1.7	-1.3
Qualifications: A levels/AS levels or equivalent	1.8	4.0	4.5	-1.9	-2.1
Ever had bowel cancer screening	1.8	2.1	2.4	1.3	1.6
Alcohol intake frequency.	1.7	4.0	4.5	2.1	1.9
Eye problems/disorders: Cataract	1.7	2.0	3.5	1.9	0.7
Fractured/broken bones in last 5 years	1.7	2.2	3.6	1.9	1.0
Diabetes (mother)	1.6	2.1	2.1	1.4	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	2.3	-1.5	-1.4
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.4	1.8	1.0
Miserableness	1.6	2.8	3.2	-1.8	-1.5
Wears glasses or contact lenses	1.6	1.8	2.1	1.3	1.5
Ever had prostate specific antigen (PSA) test	1.6	1.9	2.2	1.5	1.3
Happiness	1.5	1.8	2.3	-1.5	-1.1
Alzheimer’s Disease (including proxy)	1.4	2.0	2.1	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	2.3	-1.5	-1.5
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.8	-1.7	-0.7
Shortness of breath walking on level ground	1.4	1.6	2.7	-1.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	3.3	-1.8	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	4.1	-2.0	-1.4
Breast Cancer	1.3	3.2	4.6	2.1	1.3
Alcohol usually taken with meals	1.3	2.0	2.8	1.7	1.1
Pain all over the body in last month	1.3	1.4	1.6	-1.1	-1.3
Illnesses of siblings	1.3	1.8	2.5	-1.0	-1.6
Peak expiratory flow (PEF)	1.3	3.0	4.2	-2.0	-1.3
Pulse wave reflection index	1.3	1.6	2.3	-1.0	-1.5
Age started oral contraceptive pill	1.3	1.7	2.0	1.1	1.4
Alzheimer’s Disease (in mother)	1.2	1.4	2.1	0.8	1.5
Blood Red Count	1.2	11.3	11.4	-3.4	-3.3
Pack years adult smoking proportion	1.2	1.8	2.2	1.5	1.2
Stomach or abdominal pain in last month	1.2	1.4	1.7	1.1	1.3
Pulse rate, automated reading	1.2	3.8	3.8	1.9	2.0
Illnesses of father: Heart disease	1.2	1.7	2.0	1.4	1.2
Qualifications: nursing, teaching	1.2	1.8	2.4	-1.1	-1.5
Risk taking	1.2	1.7	2.1	-1.1	-1.5
Crohns Disease (2012)	1.1	1.8	3.6	0.2	-1.9
Systolic Blood Pressure	1.1	5.5	6.5	-2.1	-2.5
Number of children fathered	1.1	1.2	1.3	1.1	1.1
LDL Cholesterol	1.0	1.6	1.6	-1.3	-1.2
Relative age of first facial hair	1.0	2.1	2.4	-1.3	-1.6
Medication: Co-codamol	1.0	1.2	2.0	1.4	0.6
Hair/balding pattern: Pattern 2	1.0	1.2	1.3	-1.1	-1.1
Time employed in main current job	1.0	1.2	2.2	1.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.3	-1.0	-1.2
Breast cancer (self-reported)	1.0	1.2	2.4	-0.3	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.2	0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.8	0.3	1.4
Mother’s age at death	0.9	1.1	1.7	0.7	1.3
Fasting Glucose	0.8	0.9	1.4	1.2	0.6
Trunk fat percentage	0.8	3.2	3.2	1.8	1.8
Medication: Levothyroxine sodium	0.8	1.4	1.4	1.2	1.2
Nervous feelings	0.8	1.6	1.6	-1.2	-1.3
Had menopause	0.8	1.0	1.4	-1.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.3	-1.1	-0.8
Loneliness, isolation	0.8	1.1	1.8	0.6	1.3
Osteoarthritis (self-reported)	0.8	1.1	1.3	1.1	0.9
Ever smoked	0.8	1.5	1.9	-1.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.8	-0.3	-1.3
Pack years of smoking	0.8	1.2	1.3	1.1	1.0
Bipolar Disorder (2018)	0.7	1.1	1.5	-0.8	-1.2
HDL Cholesterol	0.7	1.1	2.1	-0.3	-1.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	0.4	1.2
Systolic blood pressure, automated reading	0.7	1.9	2.4	-1.5	-1.2
Angina	0.7	0.9	1.6	-0.3	-1.3
Relative age voice broke	0.7	1.1	1.7	-0.7	-1.3
Age when periods started (menarche)	0.7	1.7	2.1	-1.1	-1.4
Had other major operations	0.7	0.8	1.4	1.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.3	0.8	1.5
Father’s age at death	0.7	0.9	1.4	-1.2	-0.6
Smoking status: Previous	0.7	1.0	1.4	-1.2	-0.7
Long-standing illness, disability or infirmity	0.7	1.0	1.3	1.1	0.8
Medication: Atorvastatin	0.7	0.9	1.5	-1.2	-0.5
Vitamin and mineral supplements	0.6	0.8	1.6	-0.0	1.3
Townsend deprivation index at recruitment	0.6	0.8	1.0	-0.8	-1.0
Hearing difficulty/problems with background noise	0.6	1.0	1.3	0.8	1.2
Impedance of arm (left)	0.6	2.8	4.3	2.1	1.2
Ever highly irritable/argumentative for 2 days	0.6	0.8	0.9	-0.8	-1.0
Headache pain in last month	0.6	1.0	1.3	0.8	1.1
Glaucoma (self-reported)	0.6	0.7	1.0	-0.6	-1.0
Body fat percentage	0.6	2.4	2.7	1.4	1.6
Angina (self-reported)	0.6	0.8	1.5	-0.3	-1.2
Arm fat percentage (left)	0.6	2.4	2.9	1.4	1.7
Financial situation satisfaction	0.6	0.8	1.4	-1.2	-0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-1.1	-0.3
Medication: Lisinopril	0.6	0.8	0.9	-0.8	-0.9
Number of operations (self-reported)	0.6	0.9	1.5	1.2	0.5
Ulcerative Colitis	0.5	0.8	1.2	-0.6	-1.1
Maternal smoking around birth	0.5	0.7	1.0	-0.6	-1.0
Medication: Atenolol	0.5	0.6	0.7	-0.9	-0.7
Mouth/teeth dental problems	0.5	0.8	1.6	1.3	0.2
Allergy	0.5	1.2	1.2	-1.1	-1.1
Depression (self-reported)	0.5	0.6	0.7	0.8	0.7
Birth weight	0.5	1.0	1.3	-1.1	-0.9
Had major operations	0.5	0.6	0.6	-0.8	-0.7
Average weekly red wine intake	0.5	0.7	1.2	1.1	0.4
Mood swings	0.5	1.0	1.0	-1.0	-1.0
Back pain experienced in last month	0.5	0.7	1.0	0.6	1.0
Medication: Aspirin	0.5	0.7	1.0	1.0	0.6
Smoking status: Current	0.5	0.7	1.2	0.5	1.1
Guilty feelings	0.5	0.7	1.4	-0.3	-1.2
Medication: Paracetamol	0.5	0.7	1.3	-0.5	-1.1
Unable to work because of sickness or disability	0.5	0.7	1.2	1.1	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	0.6	0.8	0.8
Depression (Nagel 2018)	0.4	0.5	0.7	-0.8	-0.6
Schizophrenia vs Biploar Disorder	0.4	0.6	0.7	-0.7	-0.8
Ulcerative Colitis (UC)	0.4	0.7	0.8	-0.9	-0.8
Mean Putamen Volume	0.4	0.5	0.6	-0.7	-0.7
Triglycerides	0.4	0.6	1.1	-0.4	1.0
Waist Hip Ratio (WHR)	0.4	1.6	2.0	1.1	-1.4
Medication: Metformin	0.4	0.6	1.1	0.1	1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.7	-0.8	-0.5
Impedance of arm (right)	0.4	1.8	2.6	1.6	1.0
Arm fat percentage (right)	0.4	1.6	2.1	1.0	1.5
Lung cancer (father)	0.4	0.5	0.8	0.4	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.0	-1.4	-0.7
Exposure to tobacco smoke at home	0.4	0.4	0.4	-0.6	-0.6
Birth weight of first child	0.4	0.8	1.5	-0.2	-1.2
Qualifications: College or University degree	0.4	1.2	2.0	-0.6	-1.4
Medication: Allopurinol	0.4	0.5	0.7	0.6	0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	0.0	1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.0	1.0	0.4
Medication: Bendroflumethiazide	0.4	0.7	0.9	0.7	0.9
Illnesses of father: High blood pressure	0.4	0.5	0.5	-0.7	-0.7
Diastolic blood pressure, automated reading	0.4	1.4	2.1	-1.4	-0.8
Supplements: Calcium	0.4	0.4	0.8	0.1	-0.9
Heart disease (siblings)	0.4	0.5	0.7	0.6	0.9
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.6	0.6	1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	0.9	0.8	0.9
Rheumatoid Arthritis	0.3	0.4	0.7	0.2	-0.8
Blood Eosinophil Count	0.3	2.1	4.2	0.0	-2.0
Number of treatments/medications taken	0.3	0.5	0.8	0.9	0.4
Severe depression (siblings)	0.3	0.4	0.4	0.6	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	0.7	0.9
Trunk fat mass	0.3	1.5	1.6	1.2	1.2
Financial difficulties in last 2 years	0.3	0.4	0.8	-0.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.4	-1.2	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	-0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.2	1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.3	1.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.9	0.4	0.9
Medication: Amlodipine	0.3	0.4	0.9	0.9	0.0
Health satisfaction	0.3	0.4	0.6	0.4	0.8
Heart disease (mother)	0.3	0.4	0.4	-0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.3	0.8
Suffer from ‘nerves’	0.3	0.4	0.7	0.9	0.3
Overall health rating	0.3	0.6	0.8	0.9	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.7	-0.3
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.8	0.0
Hearing aid user	0.3	0.4	0.5	-0.4	-0.7
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.2	-0.8
Medication: Blood pressure	0.3	0.6	0.6	0.8	0.7
Ever depressed for a whole week	0.3	0.4	0.5	0.7	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.4	0.5	1.2
Impedance of whole body	0.3	1.5	2.5	1.6	0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.4	0.4	-0.6
Irritable Bowel Disease (IBD)	0.2	0.6	0.7	-0.6	-0.8
Prostate Cancer	0.2	0.3	0.6	0.3	0.7
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.3	0.8
Lupus	0.2	0.3	0.6	0.1	-0.8
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.4
Schizophrenia (2014)	0.2	0.5	0.9	-0.9	-0.4
Hypothyroidism (self reported)	0.2	0.4	0.6	0.5	0.8
Lung FEV1/FVC ratio	0.2	1.0	1.4	-0.8	-1.2
Lung FVC	0.2	0.8	1.4	-0.4	1.2
Sensitivity / hurt feelings	0.2	0.3	0.4	-0.3	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	0.6	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.1	0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.3	-0.4	0.6
Average weekly fortified wine intake	0.2	0.2	0.4	-0.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.3	0.5	0.6
Past tobacco smoking	0.2	0.3	0.6	0.8	0.2
Forced vital capacity (FVC)	0.2	0.7	1.2	-1.1	-0.6
Heart attack	0.2	0.2	0.3	-0.6	0.4
Diabetes (self-reported)	0.2	0.3	0.4	-0.5	0.6
Medication: Simvastatin	0.2	0.3	0.4	0.5	0.6
Fluid intelligence score	0.2	0.5	0.7	0.8	0.5
Neuroticism score	0.2	0.5	0.6	-0.5	-0.8
Hip circumference	0.2	1.1	2.0	0.3	1.4
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.7	0.4
Loud music exposure frequency	0.2	0.2	0.5	0.7	0.1
Medication: Paracetamol	0.2	0.3	0.6	-0.2	-0.8
High blood pressure (siblings)	0.2	0.3	0.5	0.2	0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	-1.0	-0.3
Worry too long after embarrassment	0.2	0.3	0.5	-0.4	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.4	-0.7
Age at first live birth	0.2	0.3	0.6	-0.1	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.2	0.8
Medication: Ibuprofen	0.2	0.2	0.4	-0.6	-0.2
Whole body fat mass	0.2	0.9	0.9	0.9	1.0
Comparative height size at age 10	0.2	0.8	1.6	1.3	0.3
Chest pain or discomfort	0.2	0.3	0.5	-0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	-0.2	-0.6
Medication: Aspirin	0.2	0.2	0.4	0.7	0.2
Knee pain experienced in last month	0.2	0.3	0.4	0.5	-0.6
Whole body fat-free mass	0.2	0.9	1.0	-0.9	-1.0
Diabetes diagnosed by doctor	0.2	0.3	0.3	-0.5	0.6
Mineral and other dietary supplements	0.2	0.3	0.6	-0.8	-0.2
Asthma (self-reported)	0.2	0.3	0.5	0.7	0.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	-0.8	0.1
Arm fat mass (left)	0.2	0.8	1.0	0.7	1.0
Arm fat-free mass (left)	0.2	0.8	0.8	-0.9	-0.9
Cholesterol lowering medication	0.2	0.3	0.5	0.7	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.7	-0.5
Worry (Nagel 2018)	0.1	0.2	0.3	-0.3	-0.5
Ovarian Cancer	0.1	0.1	0.1	-0.3	0.2
Age at First Birth	0.1	0.1	0.3	0.1	-0.5
Neuroticism (2016)	0.1	0.2	0.3	-0.2	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	0.2
Heel T-Score	0.1	0.4	0.5	-0.6	0.7
BMI	0.1	0.6	0.6	-0.8	0.7
Height	0.1	1.9	3.6	1.9	-0.4
Smoking Status	0.1	0.1	0.3	-0.1	0.5
Respiratory disease	0.1	0.2	0.3	0.6	-0.3
Chronotype (morning person)	0.1	0.3	0.6	-0.3	-0.7
Tanning	0.1	1.5	2.1	1.5	0.9
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.4	-0.5
Diabetes (father)	0.1	0.1	0.1	0.2	0.3
Leg fat-free mass (left)	0.1	0.6	0.7	-0.8	-0.8
Hand grip strength (right)	0.1	0.2	0.4	-0.6	-0.3
Current tobacco smoking	0.1	0.2	0.3	0.1	0.5
Fed-up feelings	0.1	0.2	0.2	-0.4	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.4	-0.2
High blood pressure	0.1	0.2	0.5	0.0	-0.7
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.2	-0.3
Body mass index (BMI)	0.1	0.3	0.5	-0.0	0.7
Impedance of leg (left)	0.1	0.4	0.7	0.9	0.1
Leg predicted mass (left)	0.1	0.6	0.7	-0.9	-0.7
Waist circumference	0.1	0.3	0.4	0.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.4	-0.1
Medication: Ramipril	0.1	0.1	0.1	-0.3	-0.3
Trunk fat-free mass	0.1	0.8	0.9	-0.8	-1.0
Falls in the last year	0.1	0.2	0.2	0.4	-0.3
Number of live births	0.1	0.1	0.2	-0.5	0.0
Asthma	0.1	0.3	0.4	0.7	0.3
Prospective memory result	0.1	0.2	0.3	-0.5	-0.2
Illnesses of mother	0.1	0.2	0.3	0.2	-0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.3	-0.5
Arm fat mass (right)	0.1	0.5	0.7	0.5	0.8
Trunk predicted mass	0.1	0.6	0.7	-0.7	-0.9
Standing height	0.1	0.8	1.2	0.7	-1.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.2	-0.5
Leg fat percentage (right)	0.1	0.3	0.6	0.0	0.8
Arm fat-free mass (right)	0.1	0.5	0.8	-0.5	-0.9
Comparative body size at age 10	0.1	0.3	0.4	0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.6	-0.2
Pulse wave peak to peak time	0.1	0.1	0.2	-0.2	0.5
Medication: Blood pressure	0.1	0.2	0.2	-0.3	-0.5
Medication: Omeprazole	0.1	0.1	0.2	0.2	-0.4
Mean time to correctly identify matches	0.1	0.3	0.5	0.3	0.7
Leg fat mass (right)	0.1	0.3	0.6	0.1	0.8
Arm predicted mass (right)	0.1	0.5	0.7	-0.5	-0.9
Hypertension (Self-reported)	0.1	0.2	0.3	-0.1	-0.5
Leg fat-free mass (right)	0.1	0.6	0.9	-0.7	-0.9
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.2	0.3
Osteoporosis (self-reported)	0.1	0.1	0.1	0.3	-0.2
Whole body water mass	0.1	0.6	0.7	-0.7	-0.9
Leg predicted mass (right)	0.1	0.6	0.8	-0.7	-0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.6	-0.3
Eye problems/disorders: Glaucoma	0.1	0.2	0.2	0.5	-0.3
Basal metabolic rate	0.1	0.4	0.4	-0.6	-0.6
Irritability	0.1	0.2	0.4	0.3	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.1	0.3
Pain experienced in last month	0.1	0.1	0.1	0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.5	0.3
Leg fat mass (left)	0.1	0.2	0.4	0.1	0.6
Arm predicted mass (left)	0.1	0.3	0.3	-0.6	-0.6
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.2	0.1
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.3
Schizophrenia (2018)	0.0	0.1	0.1	-0.2	0.3
Crohns Disease (2017)	0.0	0.1	0.2	-0.0	-0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.0	0.1	0.1	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	-0.0
Blood Platelet Count	0.0	0.0	0.0	-0.2	0.2
Allergy or Eczema	0.0	0.1	0.1	0.4	0.2
Cardiovascular Disease	0.0	0.1	0.2	0.5	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.3	0.2
Neuroticism	0.0	0.1	0.2	-0.0	-0.4
Hair Pigment	0.0	0.1	0.1	-0.3	-0.3
Hand grip strength (left)	0.0	0.1	0.2	-0.1	0.4
Average weekly spirits intake	0.0	0.0	0.1	0.1	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.3	-0.0
Supplements: Zinc	0.0	0.1	0.1	0.1	0.3
Impedance of leg (right)	0.0	0.1	0.2	0.5	0.2
Sitting height	0.0	0.0	0.0	0.1	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.0	-0.1
Qualifications: None of the above	0.0	0.0	0.1	0.1	0.3
Weight	0.0	0.2	0.2	0.4	0.4
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.0	-0.0
Worrier / anxious feelings	0.0	0.0	0.0	0.2	0.0
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.1	-0.2
Pulse rate	0.0	0.0	0.1	0.1	0.2
Noisy workplace	0.0	0.0	0.0	-0.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	-0.0	0.2
Breastfed as a baby	0.0	0.0	0.1	-0.1	0.3
Tense / ‘highly strung’	0.0	0.0	0.1	0.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	-0.3	0.1
Neck or shoulder pain in last month	0.0	0.1	0.1	-0.3	-0.1
Number of full sisters	0.0	0.1	0.1	-0.3	0.0
Age at last live birth	0.0	0.1	0.1	-0.2	-0.3
Leg pain on walking	0.0	0.0	0.0	0.0	0.1
Supplements: Vitamin C	0.0	0.0	0.0	0.0	0.0
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.3	0.1
Medication for cholesterol	0.0	0.0	0.1	0.2	-0.2
Medication: Gliclazide	0.0	0.0	0.1	-0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.2	0.1
High cholesterol (Self-reported)	0.0	0.1	0.1	0.2	0.4
Leg fat percentage (left)	0.0	0.1	0.3	-0.0	0.5

Hub : Genes

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Trait associations