Hub : Genes

TLN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1250 0.0500 7.0e-03 0.116 NA 0.069 NA 0.088 6.2e-07 NA 1.2e-04 NA 1.4e-05
2 GTEx Nerve Tibial 0.2972 0.0718 4.5e-05 0.072 NA 0.109 NA 0.109 8.2e-06 NA 3.9e-08 NA 4.3e-08
3 METSIM Adipose 0.0435 0.0214 1.7e-02 -0.001 0.012 -0.001 0.012 -0.002 6.4e-01 0.0051 4.0e-01 0.0058 9.6e-01
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0737 0.0326 7.7e-03 -0.002 0.011 -0.002 NA -0.002 6.3e-01 0.0200 7.4e-01 NA 8.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.4 0.6 2.0 -0.0 1.4 -0.5 0.3
Bipolar Disorder or Schizophrenia 0.4 1.0 2.2 -1.0 1.5 -0.4 -0.7
Depressed Affect (Nagel 2018) 1.2 2.4 7.3 -0.0 2.7 1.4 -0.6
Depression (Nagel 2018) 0.6 0.8 1.2 0.7 1.1 0.6 -1.1
Intelligence (Savage-Jansen 2018) 1.1 3.3 9.5 1.2 0.5 -1.4 3.1
Neuroticism (Nagel 2018) 0.7 1.7 4.0 -0.5 2.0 0.3 -1.6
Schizophrenia (2018) 0.4 0.9 1.6 -1.3 0.8 -0.1 -1.2
Schizophrenia vs Biploar Disorder 1.0 1.4 3.0 -1.7 -0.9 0.5 -1.2
Worry (Nagel 2018) 0.1 0.3 0.9 -0.1 0.2 -0.5 -0.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 0.6 -0.0 0.0 0.7
Alzheimer’s Disease (in father) 0.9 1.0 2.8 1.0 0.0 -0.5 1.7
Alzheimer’s Disease (including proxy) 0.9 1.3 3.0 1.2 0.2 0.8 1.7
Crohns Disease (2017) 0.3 0.8 2.1 -0.4 0.7 -0.5 -1.5
Irritable Bowel Disease (IBD) 0.3 0.7 2.4 0.4 0.4 0.2 -1.5
Ulcerative Colitis (UC) 0.3 0.6 1.4 0.6 0.3 0.7 -1.2
Major Depression (MDD) 0.2 0.2 0.5 -0.7 -0.0 0.6 0.2
Reaction Time 0.2 0.4 0.8 0.6 0.5 -0.9 0.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.8 -0.7 0.8 -1.4 1.0
Breast Cancer 2.4 5.8 14.5 -3.8 -0.7 -2.8 0.4
Ovarian Cancer 0.4 0.5 1.0 0.3 0.6 -1.0 -0.7
Prostate Cancer 0.8 1.1 4.0 0.1 -0.6 -2.0 0.1
Age at First Birth 0.6 0.9 1.9 1.1 -0.2 -1.4 0.7
Bipolar Disorder (2011) 0.4 0.3 0.7 -0.1 0.8 0.8 0.1
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 -0.3 -0.2 -0.1 -0.4
Coronary Artery Disease (CAD) 0.1 0.2 0.4 -0.1 0.2 -0.7 -0.4
Crohns Disease (2012) 0.1 0.2 0.4 -0.1 -0.5 -0.4 -0.7
Mean Putamen Volume 2.2 2.5 5.7 -1.1 -0.6 -2.4 1.7
Fasting Glucose 0.9 1.1 2.0 -1.1 -1.1 -1.4 -0.3
HbA1C 1.2 1.3 2.6 -1.6 -0.6 -1.5 -0.0
HDL Cholesterol 0.9 1.4 3.7 1.1 1.9 0.5 0.7
LDL Cholesterol 0.5 0.7 1.2 -0.7 0.9 1.1 0.7
Lupus 0.2 0.3 0.6 0.3 0.6 -0.1 -0.8
Neuroticism (2016) 0.4 0.6 1.7 -1.3 0.7 -0.1 -0.4
Primary Biliary Cirrhosis 0.5 0.7 1.6 1.2 0.5 0.9 -0.4
Rheumatoid Arthritis 1.4 1.9 6.7 -0.3 0.8 2.6 -0.5
Schizophrenia (2014) 0.6 1.3 2.1 -1.4 1.1 0.3 -1.4
Triglycerides 0.6 1.0 2.8 -0.2 -1.7 0.1 1.1
Type 2 Diabetes (T2D) (2012) 6.6 7.6 15.1 -0.9 -3.9 -3.7 0.7
Ulcerative Colitis 0.1 0.2 0.5 0.7 -0.2 0.4 -0.3
Blood Eosinophil Count 0.2 1.8 4.3 -2.1 0.9 -1.2 -1.0
Blood Platelet Count 1.1 12.6 42.2 -0.8 2.7 6.5 -0.4
Blood Red Count 0.3 3.1 9.5 0.6 -3.1 1.5 -0.4
Blood White Count 1.4 10.2 23.7 -4.9 -2.4 2.6 -2.1
Heel T-Score 1.4 11.0 21.3 -2.4 4.6 2.7 -3.1
BMI 0.5 2.7 7.5 -2.7 0.5 -1.4 1.1
Height 0.1 2.8 7.9 -0.3 -1.7 -2.8 0.2
Waist Hip Ratio (WHR) 1.2 5.4 11.6 3.4 -0.4 2.1 2.4
Systolic Blood Pressure 0.4 1.9 6.5 -2.5 -0.5 -0.5 0.9
Smoking Status 0.3 0.7 1.3 -0.6 -1.0 1.2 -0.4
Allergy or Eczema 0.4 1.1 1.9 -1.2 -1.4 -0.9 0.1
Cardiovascular Disease 0.1 0.2 0.5 -0.1 0.3 0.3 0.7
Hypothyroidism (self reported) 0.7 1.7 4.1 -0.2 -2.0 -1.6 -0.3
Respiratory disease 0.3 0.7 1.7 -1.3 0.8 0.4 -0.7
Type 2 Diabetes (T2D) (2018) 0.9 1.7 2.9 1.3 -1.7 -1.3 0.7
Lung FEV1/FVC ratio 0.4 2.2 6.0 0.0 1.4 2.4 -0.8
Lung FVC 0.8 4.2 10.7 -3.3 0.6 -2.1 -1.2
Neuroticism 0.4 1.1 3.5 -0.3 1.9 0.8 -0.2
Chronotype (morning person) 0.8 1.8 5.4 2.3 -0.0 0.9 0.9
Hair Pigment 0.1 2.3 4.8 0.5 -2.2 2.0 -0.2
Tanning 0.1 0.7 2.6 0.1 -0.5 -1.6 -0.0
Hand grip strength (left) 0.5 1.3 2.3 -1.2 -1.5 0.1 -1.1
Number of treatments/medications taken 0.2 0.3 0.7 -0.9 0.2 0.7 -0.3
Average weekly spirits intake 1.2 1.5 5.5 -0.5 0.6 2.3 -0.1
Sensitivity / hurt feelings 0.7 1.2 3.1 -1.1 0.4 0.4 -1.8
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 0.8 0.1 1.1 0.2
Hearing difficulty/problems: Yes 0.4 0.7 1.7 1.0 -0.2 -0.1 1.3
Relative age of first facial hair 0.5 1.0 1.8 0.4 -0.9 1.1 -1.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.4 0.2 -0.0 -0.5 -1.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.3 0.1 -1.1 -0.6 0.3
Ever had hysterectomy (womb removed) 1.1 1.2 2.5 1.6 1.0 -0.2 1.2
Systolic blood pressure, automated reading 0.7 2.1 6.2 -2.5 -0.4 -0.6 1.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 2.2 0.0 0.8 -0.1 1.5
Angina 0.3 0.5 1.1 0.1 0.0 -0.8 1.1
Medication for hormone replacement therapy 0.1 0.2 0.5 0.2 -0.7 -0.3 0.1
Vitamin and mineral supplements 1.1 1.5 2.4 -0.7 0.8 1.6 1.5
Supplements: Zinc 0.3 0.3 0.5 0.6 -0.3 -0.7 0.4
Medication: Co-codamol 1.5 1.7 4.7 -1.3 2.2 -0.2 -0.7
Medication: Metformin 0.7 1.0 2.7 0.8 -0.6 -0.3 1.6
Diabetes (father) 0.5 0.6 1.9 0.1 -0.7 -0.0 1.4
Diabetes (mother) 3.0 3.9 8.4 -0.5 -2.4 -2.9 1.1
Severe depression (siblings) 1.9 2.1 3.3 1.8 -0.6 1.7 1.3
Pack years adult smoking proportion 0.4 0.6 1.6 -1.3 -0.0 0.7 0.7
Impedance of leg (right) 1.3 6.2 16.3 4.0 -1.8 2.2 0.5
Leg fat-free mass (left) 0.5 2.8 5.8 -2.4 -0.4 -2.1 1.1
Trunk fat percentage 0.5 2.2 6.5 1.5 -0.2 -0.2 2.5
Hand grip strength (right) 0.3 0.7 1.3 -0.9 -1.1 0.6 -0.5
Townsend deprivation index at recruitment 1.3 1.9 3.9 -0.4 0.7 1.8 2.0
Current tobacco smoking 0.4 0.6 1.5 -0.8 0.1 1.2 -0.5
Average weekly fortified wine intake 0.1 0.1 0.2 -0.4 0.3 -0.2 0.1
Maternal smoking around birth 1.0 1.5 4.9 -0.4 -0.6 0.8 2.2
Fed-up feelings 0.7 1.3 3.7 0.9 0.4 1.9 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.7 1.3 -0.2 1.1 -0.1
Relative age voice broke 0.7 1.1 3.0 0.1 -1.2 -0.2 -1.7
Taking other prescription medications 0.6 1.0 2.6 -1.1 -0.3 0.4 -1.6
Age when periods started (menarche) 0.7 1.7 5.9 -0.7 -2.4 0.0 -0.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.2 -0.2 -1.4 1.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 7.8 -1.1 1.8 2.8 -1.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 3.3 0.2 0.4 -0.0 1.8
Qualifications: CSEs or equivalent 0.3 0.4 1.0 0.3 -1.0 0.2 -0.7
Serious illness, injury or assault to yourself 0.6 0.7 1.9 -0.1 -1.4 0.5 -0.8
High blood pressure 0.2 0.6 1.9 -1.4 0.6 -0.1 0.3
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.9 -1.1 -1.1 -1.7 0.3
Multivitamins +/- minerals 1.1 1.4 4.8 -0.4 -0.4 -2.2 -0.7
Stomach or abdominal pain in last month 0.5 0.6 1.7 -1.3 0.4 0.6 -0.1
Supplements: Glucosamine 0.7 0.9 2.1 0.9 0.9 -1.4 0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.2 1.1 -1.0 0.1 0.2
Medication: Atenolol 0.6 0.8 1.4 1.2 1.0 0.8 -0.2
Medication: Levothyroxine sodium 0.4 0.8 2.2 -0.9 -0.2 -1.5 0.1
Sitting height 0.5 3.8 7.3 -2.4 -1.4 -2.7 0.6
Chronic bronchitis/emphysema (father) 0.4 0.5 1.5 0.6 0.1 1.2 0.2
High blood pressure (mother) 0.4 0.6 2.1 0.1 -0.5 -0.0 -1.4
Body mass index (BMI) 0.4 1.8 5.1 -2.3 0.4 -0.7 1.1
Impedance of leg (left) 1.4 6.7 16.5 4.1 -1.9 2.3 1.1
Leg predicted mass (left) 0.5 2.7 5.5 -2.3 -0.3 -2.1 1.0
Trunk fat mass 0.3 1.5 5.2 0.0 -0.4 -0.8 2.3
Waist circumference 0.2 0.8 2.4 -0.3 0.1 -0.7 1.6
Number of incorrect matches in round 0.6 1.0 2.7 0.1 -0.2 1.6 -1.1
Past tobacco smoking 0.2 0.3 1.0 -0.0 0.4 -0.5 1.0
Alcohol usually taken with meals 0.6 1.0 2.8 -0.9 0.2 0.6 -1.7
Nervous feelings 0.1 0.2 0.7 -0.2 0.1 -0.8 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 4.5 -0.7 0.2 0.1 -2.1
Hearing difficulty/problems with background noise 0.4 0.6 2.0 -0.3 -0.5 -1.4 0.3
Hair/balding pattern: Pattern 2 1.1 1.4 3.0 -0.2 1.1 1.7 1.2
Had menopause 1.7 2.2 5.0 0.2 1.9 -2.2 0.2
Had other major operations 0.6 0.8 1.9 1.4 0.4 -0.8 0.6
Forced vital capacity (FVC) 0.6 2.4 7.8 -0.9 -0.9 -2.8 0.5
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.6 6.3 -0.6 1.4 2.5 -1.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.6 -0.1 -0.5 0.7 -1.6
Qualifications: None of the above 0.5 1.0 4.0 -0.1 0.2 2.0 0.1
Financial difficulties in last 2 years 1.5 2.1 6.2 -1.4 0.1 2.5 -0.1
Mouth/teeth dental problems 1.3 1.9 5.0 2.2 -1.6 0.1 0.4
Heart attack 0.7 0.9 3.1 -0.3 -0.4 -1.8 -0.5
Allergy 0.6 1.4 2.9 1.7 0.9 1.3 -0.3
Pain all over the body in last month 0.9 1.0 2.6 -1.6 0.7 -0.9 0.1
Diabetes (self-reported) 0.4 0.6 2.1 1.5 -0.2 -0.6 -0.2
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.0 0.5 0.9 -0.8 1.4
Medication: Ramipril 0.6 0.8 1.9 0.5 1.0 -0.2 1.4
Medication: Simvastatin 0.2 0.3 1.1 0.0 0.4 -1.1 -0.2
Fluid intelligence score 0.8 1.7 4.0 0.5 1.5 -0.6 2.0
Illnesses of siblings 0.1 0.2 0.4 0.6 0.2 0.2 -0.5
Neuroticism score 0.1 0.3 1.0 0.1 1.0 0.2 -0.3
Weight 0.5 2.3 4.4 -2.1 -0.4 -1.6 1.4
Impedance of arm (right) 2.5 11.8 42.9 6.5 0.1 1.6 1.3
Arm fat percentage (right) 0.4 1.4 4.5 0.6 0.8 -0.4 2.1
Trunk fat-free mass 1.0 5.5 15.2 -3.9 -0.6 -2.6 -0.1
Hip circumference 0.5 2.0 5.4 -1.1 0.5 -2.3 1.1
Time employed in main current job 1.8 2.1 5.4 0.1 -1.5 -2.3 0.8
Alcohol intake versus 10 years previously 0.2 0.3 0.9 -0.5 0.2 0.2 1.0
Father’s age at death 1.1 1.4 2.5 1.0 1.6 -0.9 1.2
Worrier / anxious feelings 0.8 1.6 4.7 -0.1 -1.2 -0.2 -2.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.7 -0.2 0.8 0.9 -0.1
Falls in the last year 0.6 0.8 1.9 0.3 0.9 0.6 -1.4
Hair/balding pattern: Pattern 3 0.9 1.4 2.8 -1.7 -0.4 0.7 -1.5
Number of live births 0.1 0.2 0.2 0.4 0.5 0.4 0.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.2 3.7 -0.9 -0.5 -1.9 0.2
Pulse rate 0.5 0.8 1.9 -1.0 0.4 1.4 0.1
Happiness 1.9 2.3 5.9 -2.4 -0.2 -0.4 -1.8
Noisy workplace 0.6 0.8 2.2 -0.6 1.5 0.6 -0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.3 0.6 0.4 -0.5 -0.8 -0.6
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.7 -0.5 -1.1 0.7 -1.9
Mouth/teeth dental problems: Dentures 0.5 0.9 2.1 -1.4 0.3 0.8 0.8
Asthma 0.3 0.6 1.2 -1.1 -0.4 -0.4 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.9 -1.0 1.4 0.7 0.4
Medication: Cholesterol lowering 0.5 0.7 1.4 -0.7 0.5 -1.2 -0.9
Depression (self-reported) 1.4 1.6 3.7 -0.2 -1.0 1.3 -1.9
Medication: Lansoprazole 1.1 1.3 1.9 -1.3 -1.3 0.4 -1.4
Prospective memory result 0.7 0.9 2.1 -0.7 0.8 1.5 -0.5
Lung cancer (father) 2.4 2.8 5.5 2.3 -2.1 -0.9 0.7
Illnesses of mother 0.2 0.2 0.7 0.1 0.8 -0.0 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.5 -1.1 -0.2 -1.9 -0.2
Pulse wave Arterial Stiffness index 0.3 0.3 0.8 0.7 0.3 0.9 0.2
Impedance of arm (left) 2.3 10.7 38.4 6.2 -0.2 1.6 1.2
Arm fat mass (right) 0.3 1.3 4.4 -0.5 0.4 -0.8 2.1
Trunk predicted mass 0.9 5.4 14.7 -3.8 -0.5 -2.6 -0.0
Standing height 0.3 2.6 5.2 0.2 -2.1 -2.3 0.8
Length of working week for main job 0.4 0.4 0.9 0.1 0.3 0.9 -0.9
Exposure to tobacco smoke at home 0.7 0.8 1.4 -1.2 -0.6 -0.4 1.1
Breastfed as a baby 1.2 1.5 3.0 1.5 1.7 -0.6 0.8
Tense / ‘highly strung’ 0.1 0.2 0.8 -0.3 0.9 0.1 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.9 -0.1 -0.7 1.0 -0.9
Hair/balding pattern: Pattern 4 0.6 1.4 4.0 -0.6 -1.1 -2.0 -0.0
Birth weight of first child 0.9 1.7 4.5 1.4 -0.1 0.5 2.1
Peak expiratory flow (PEF) 0.2 0.5 1.8 -0.5 -0.1 -1.3 0.4
Pulse wave reflection index 1.8 2.3 5.8 1.6 0.1 0.9 2.4
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.3 0.3 -0.4 1.5 0.3
Loud music exposure frequency 3.1 3.4 11.8 0.3 -1.0 -0.7 3.4
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 1.9 1.4 -1.2 -0.3 0.7
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.2 -1.2 1.5 0.5 -1.1
Blood clot in the leg (DVT) 0.5 0.7 2.0 -0.1 0.7 -1.4 0.6
Medication: Paracetamol 0.8 1.3 2.3 -0.8 1.5 1.5 0.1
Headache pain in last month 0.9 1.5 2.9 -1.7 0.5 0.7 -1.5
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.8 0.8 -0.3 0.9 -0.1
Glaucoma (self-reported) 0.2 0.3 0.8 0.3 0.3 0.1 0.9
Gout (self-reported) 0.5 0.7 2.6 -0.5 0.1 -0.2 -1.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 5.0 -0.2 -1.2 -2.2 -0.3
Medication: Amlodipine 0.1 0.1 0.4 -0.6 0.4 -0.2 0.0
Medication: Ventolin 100micrograms inhaler 1.0 1.2 3.8 -0.3 -0.4 0.9 2.0
Birth weight 0.5 1.2 3.6 1.9 0.8 0.5 -0.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.4 1.2 -0.5 0.4 1.0
High blood pressure (siblings) 0.4 0.5 1.0 -1.0 0.9 0.4 -0.2
Forced vital capacity (FVC), Best measure 0.3 1.2 4.3 -0.5 -0.7 -2.1 -0.1
Body fat percentage 0.5 1.9 6.4 1.1 -0.0 -0.1 2.5
Leg fat percentage (right) 0.1 0.5 1.6 -0.4 -0.2 0.3 1.3
Arm fat-free mass (right) 1.1 5.7 14.2 -3.8 -1.4 -2.4 0.9
Exposure to tobacco smoke outside home 0.5 0.6 2.0 -0.5 -0.3 1.4 -0.5
Comparative body size at age 10 0.5 1.5 3.0 -0.6 1.7 -1.0 1.2
Number of full brothers 1.6 2.0 6.9 -0.7 2.6 -0.6 -0.6
Worry too long after embarrassment 0.6 1.1 2.1 0.1 1.4 -0.2 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.3 -0.5 0.7 0.4 -1.1
Wheeze or whistling in the chest in last year 1.4 2.5 5.0 -2.2 1.1 1.5 -1.3
Number of children fathered 0.8 0.9 2.2 -1.1 1.5 0.5 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 2.1 0.6 -0.6 -1.4 -0.1
Age at first live birth 0.3 0.6 1.6 1.2 -0.8 0.0 -0.2
Pulse wave peak to peak time 0.4 0.4 1.0 -0.6 -0.5 -1.0 -0.3
Health satisfaction 0.5 0.6 1.6 -1.3 0.9 0.2 -0.1
Shortness of breath walking on level ground 0.4 0.5 0.9 -0.2 -0.7 1.0 -0.8
Qualifications: College or University degree 0.8 2.6 5.9 2.0 -0.8 -2.4 -0.3
Eye problems/disorders: None of the above 0.5 0.6 0.9 0.3 -0.9 0.9 -0.7
Mouth/teeth dental problems: Loose teeth 1.9 2.3 3.1 -0.9 1.8 1.8 -1.4
Emphysema/chronic bronchitis 0.9 1.0 2.7 -1.7 0.4 -0.1 -1.1
Medication for pain relief, constipation, heartburn 0.8 1.4 3.5 1.9 -1.4 -0.5 0.1
Neck or shoulder pain in last month 0.4 0.6 2.1 0.0 -0.0 0.4 1.4
Medication: Blood pressure 1.1 1.9 3.2 -1.6 0.7 -1.2 1.8
Angina (self-reported) 0.3 0.4 1.1 0.1 0.3 -0.5 1.0
Migraine (self-reported) 2.7 3.4 7.3 1.2 -1.6 1.4 -2.7
Medication: Ibuprofen 1.1 1.3 2.5 -1.4 1.6 0.5 0.8
Medication: Allopurinol 0.8 1.1 2.9 -0.8 0.7 0.6 -1.7
Medication: Omeprazole 0.2 0.2 0.7 -0.3 -0.8 -0.2 0.4
Medication: Seretide 50 evohaler 0.2 0.2 0.4 -0.4 -0.6 0.3 -0.5
Mean time to correctly identify matches 0.2 0.5 0.8 0.9 0.8 -0.4 0.5
Heart disease (mother) 0.3 0.3 0.7 -0.5 -0.8 -0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.9 -0.6 -0.5 -1.4 -0.5
Whole body fat mass 0.3 1.3 4.9 -0.2 -0.2 -0.6 2.2
Leg fat mass (right) 0.3 1.2 4.0 -0.6 -0.3 -0.3 2.0
Arm predicted mass (right) 1.2 6.2 15.2 -3.9 -1.5 -2.7 0.6
Pulse rate, automated reading 1.1 3.6 7.9 -2.8 0.5 2.4 0.4
Alcohol intake frequency. 0.6 1.5 4.0 -1.1 -0.0 -2.0 0.9
Comparative height size at age 10 0.2 1.4 4.0 0.4 1.0 -2.0 0.5
Number of full sisters 0.3 0.4 0.8 0.4 -0.9 0.8 -0.4
Suffer from ‘nerves’ 0.2 0.3 1.1 1.0 -0.3 -0.0 -0.3
Overall health rating 0.9 1.9 3.1 -1.4 1.0 1.8 -1.1
Chest pain or discomfort 1.3 1.8 3.1 -1.8 1.3 1.6 0.1
Had major operations 0.3 0.3 0.8 -0.1 0.9 0.3 -0.5
Age at last live birth 0.2 0.3 0.9 1.0 0.4 -0.4 -0.3
Family relationship satisfaction 1.2 1.4 4.6 -0.5 0.8 -2.2 -0.5
Leg pain on walking 0.9 1.1 3.1 -0.7 1.8 0.2 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 2.1 -1.4 0.1 0.3 0.2
Commuting to job workplace: Car/motor vehicle 1.3 1.4 3.6 1.4 -0.0 1.9 0.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.6 0.2 1.3 -1.1 1.2
Medication: Aspirin 0.9 1.2 3.2 -1.1 0.2 -1.8 -0.6
Supplements: Vitamin C 0.5 0.6 2.3 0.3 -0.1 -0.3 -1.5
Knee pain experienced in last month 0.5 0.8 2.0 0.9 0.5 0.3 1.4
Hypertension (Self-reported) 0.2 0.5 1.8 -1.4 0.2 -0.1 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 1.9 4.5 -2.1 0.1 1.5 -0.9
Illnesses of father: Heart disease 0.5 0.6 1.6 -0.7 -1.3 -0.5 -0.5
Illnesses of siblings: Diabetes 0.5 0.6 1.5 0.9 -1.2 0.0 0.2
Smoking status: Previous 0.2 0.3 0.7 0.1 -0.8 0.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 3.5 0.8 -1.4 -1.9 0.3
Whole body fat-free mass 0.7 4.3 11.0 -3.3 -0.5 -2.4 0.5
Leg fat-free mass (right) 0.6 3.0 6.0 -2.5 -0.2 -2.2 1.1
Arm fat percentage (left) 0.3 1.1 3.8 0.4 0.6 -0.2 1.9
Average weekly red wine intake 0.1 0.1 0.4 0.1 0.6 -0.2 0.1
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 0.3 -0.4 0.9 0.7
Mood swings 1.3 2.3 4.1 -1.2 2.0 1.3 -1.5
Loneliness, isolation 1.3 1.7 3.5 0.6 1.9 1.1 1.4
Long-standing illness, disability or infirmity 0.5 0.8 1.8 1.1 0.6 1.3 0.1
Ever had bowel cancer screening 0.4 0.5 1.1 0.2 0.9 -0.3 1.0
Diabetes diagnosed by doctor 0.3 0.4 0.8 0.9 -0.5 -0.8 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.1 0.0 0.2 -1.1 -1.5
Friendships satisfaction 0.3 0.4 1.0 0.1 -0.6 -1.0 -0.4
Qualifications: nursing, teaching 0.5 0.8 1.3 0.9 1.1 -1.0 0.2
Commuting to job workplace: Walk 0.0 0.0 0.1 -0.2 0.2 0.2 0.2
Eye problems/disorders: Cataract 1.1 1.2 4.8 0.2 2.2 -0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.6 -0.9 0.5 -0.8 1.6
Medication for cholesterol 0.6 1.0 3.2 -0.7 1.8 -0.2 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.7 -0.9 0.3 -0.8 0.6
Back pain experienced in last month 0.7 1.0 3.8 -2.0 0.2 -0.1 -0.2
Mineral and other dietary supplements 0.2 0.3 0.7 -0.8 -0.2 0.1 -0.6
Breast cancer (self-reported) 0.5 0.6 1.2 0.5 1.1 1.0 0.3
Asthma (self-reported) 0.3 0.6 1.4 -1.2 -0.4 -0.5 -0.7
Osteoporosis (self-reported) 0.1 0.2 0.4 0.4 -0.2 0.1 0.6
Osteoarthritis (self-reported) 0.7 0.9 1.1 -1.0 0.7 1.0 1.0
Medication: Aspirin 1.6 2.1 3.9 -1.7 0.6 -2.0 -1.0
Medication: Gliclazide 1.0 1.1 2.0 0.8 -1.2 0.6 -1.4
Illnesses of father: None of the above (group 1) 0.5 0.6 1.6 -0.4 1.3 -0.2 -0.8
Smoking status: Current 0.3 0.4 1.5 -0.2 0.1 1.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 5.7 -2.4 1.4 -1.4 -0.9
Whole body water mass 0.8 4.5 11.6 -3.4 -0.4 -2.4 0.5
Leg predicted mass (right) 0.6 3.0 5.9 -2.4 -0.2 -2.2 1.2
Arm fat mass (left) 0.4 1.4 4.5 -0.7 0.2 -0.8 2.1
Number of self-reported non-cancer illnesses 0.4 0.6 0.9 -1.0 0.9 -0.1 -0.9
Average weekly champagne plus white wine intake 1.0 1.3 2.2 -1.5 1.4 -0.7 -0.9
Miserableness 0.6 1.0 2.9 -0.0 1.1 1.7 0.3
Guilty feelings 0.4 0.5 1.1 -0.2 0.0 -1.0 -1.0
Wears glasses or contact lenses 0.3 0.4 0.9 -0.5 0.6 0.1 -1.0
Ever taken oral contraceptive pill 0.9 1.0 1.9 -0.2 1.0 1.4 1.0
Hearing aid user 0.3 0.4 0.7 0.8 0.3 0.8 0.4
Mother’s age at death 0.2 0.3 0.9 -0.1 0.2 0.5 -0.9
Financial situation satisfaction 0.3 0.4 0.8 -0.9 -0.4 0.6 0.5
Tinnitus: Yes, now most or all of the time 2.0 2.4 6.9 -1.1 2.6 0.6 -1.0
Commuting to job workplace: Public transport 0.7 0.8 2.5 0.4 0.3 -1.6 -0.6
Eye problems/disorders: Glaucoma 0.3 0.4 1.5 -0.2 -0.3 0.0 1.2
Medication: Blood pressure 0.2 0.5 0.8 0.7 -0.5 0.9 -0.5
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.9 0.5 -0.3 -1.4 0.8
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.5 -0.6 0.4 0.7 0.7
High cholesterol (Self-reported) 0.3 0.5 1.5 -0.5 1.2 -0.1 -0.3
Medication: Bendroflumethiazide 0.1 0.1 0.3 0.1 -0.1 -0.5 -0.4
Medication: Paracetamol 0.7 1.2 2.5 -0.6 1.6 1.3 0.0
Medication: Lisinopril 1.4 1.7 5.8 -2.4 0.2 -0.8 0.7
Medication: Atorvastatin 1.6 2.0 3.2 -1.3 1.8 0.8 -1.6
Illnesses of father: High blood pressure 0.4 0.5 1.1 -0.6 -1.0 0.7 0.5
Alcohol drinker status: Never 0.6 0.7 1.6 -1.3 0.3 -1.0 -0.2
Ever smoked 0.1 0.2 0.7 0.1 -0.2 0.4 -0.9
Basal metabolic rate 0.7 3.7 9.6 -3.1 -0.5 -2.1 0.9
Leg fat percentage (left) 0.2 0.7 2.4 -0.6 -0.1 0.4 1.5
Arm fat-free mass (left) 1.0 5.3 14.4 -3.8 -0.6 -2.2 1.2
Number of operations (self-reported) 0.9 1.3 4.7 0.6 2.2 -0.4 -0.3
Average weekly beer plus cider intake 0.4 0.6 1.6 -0.4 -0.6 1.3 0.6
Irritability 1.0 1.8 3.3 -1.8 1.6 0.7 -0.9
Risk taking 1.0 1.5 3.3 -0.9 1.2 1.8 -0.7
Ever had prostate specific antigen (PSA) test 2.2 2.5 5.2 1.4 1.8 0.1 -2.3
Fractured/broken bones in last 5 years 2.4 3.1 7.1 0.8 2.1 2.7 0.3
Age started oral contraceptive pill 0.8 0.9 2.4 -0.4 -0.2 -1.1 1.6
Diastolic blood pressure, automated reading 1.1 3.4 5.4 2.3 -1.8 1.8 1.4
Ever depressed for a whole week 0.2 0.3 0.5 0.7 -0.4 -0.1 0.7
Unable to work because of sickness or disability 0.6 0.7 1.9 -0.4 -0.9 1.4 -0.3
Commuting to job workplace: Cycle 0.9 1.1 3.8 0.2 -1.9 -0.8 -0.4
Myopia 0.5 0.8 1.8 0.9 1.3 0.7 -0.1
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.8 0.9 -0.6 0.2 -0.1
Cholesterol lowering medication 0.1 0.1 0.4 0.6 -0.0 -0.2 0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.3 -0.1 -0.6 1.2 0.1
Pain experienced in last month 1.2 2.0 6.9 2.6 -0.2 0.4 0.9
Supplements: Calcium 1.7 1.8 5.5 2.3 1.0 0.7 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 -0.6 1.0 0.5 -1.0
Heart attack/myocardial infarction (self-reported) 0.7 0.8 3.0 -0.2 -0.3 -1.7 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.7 0.1 0.6 -1.3 0.7
Heart disease (siblings) 0.9 1.1 3.9 -0.4 -2.0 -0.5 -0.5
Alcohol drinker status: Previous 1.2 1.3 3.4 -0.4 1.8 -1.1 0.7
Pack years of smoking 0.4 0.6 1.6 -1.2 0.2 0.6 0.8
Impedance of whole body 2.0 10.1 32.6 5.7 -1.3 2.0 1.5
Leg fat mass (left) 0.4 1.4 4.6 -1.0 -0.4 -0.4 2.1
Arm predicted mass (left) 1.0 5.1 12.8 -3.6 -0.8 -2.4 0.9