TWAS hub - TLN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1250	0.0500	7.0e-03	0.116	NA	0.069	NA	0.088	6.2e-07	NA	1.2e-04	NA	1.4e-05
2	GTEx	Nerve Tibial	0.2972	0.0718	4.5e-05	0.072	NA	0.109	NA	0.109	8.2e-06	NA	3.9e-08	NA	4.3e-08
3	METSIM	Adipose	0.0435	0.0214	1.7e-02	-0.001	0.012	-0.001	0.012	-0.002	6.4e-01	0.0051	4.0e-01	0.0058	9.6e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0737	0.0326	7.7e-03	-0.002	0.011	-0.002	NA	-0.002	6.3e-01	0.0200	7.4e-01	NA	8.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Type 2 Diabetes (T2D) (2012)	6.6	7.6	15.1	-0.9	-3.9	-3.7	0.7
Loud music exposure frequency	3.1	3.4	11.8	0.3	-1.0	-0.7	3.4
Diabetes (mother)	3.0	3.9	8.4	-0.5	-2.4	-2.9	1.1
Migraine (self-reported)	2.7	3.4	7.3	1.2	-1.6	1.4	-2.7
Impedance of arm (right)	2.5	11.8	42.9	6.5	0.1	1.6	1.3
Breast Cancer	2.4	5.8	14.5	-3.8	-0.7	-2.8	0.4
Lung cancer (father)	2.4	2.8	5.5	2.3	-2.1	-0.9	0.7
Fractured/broken bones in last 5 years	2.4	3.1	7.1	0.8	2.1	2.7	0.3
Impedance of arm (left)	2.3	10.7	38.4	6.2	-0.2	1.6	1.2
Mean Putamen Volume	2.2	2.5	5.7	-1.1	-0.6	-2.4	1.7
Ever had prostate specific antigen (PSA) test	2.2	2.5	5.2	1.4	1.8	0.1	-2.3
Tinnitus: Yes, now most or all of the time	2.0	2.4	6.9	-1.1	2.6	0.6	-1.0
Impedance of whole body	2.0	10.1	32.6	5.7	-1.3	2.0	1.5
Severe depression (siblings)	1.9	2.1	3.3	1.8	-0.6	1.7	1.3
Happiness	1.9	2.3	5.9	-2.4	-0.2	-0.4	-1.8
Mouth/teeth dental problems: Loose teeth	1.9	2.3	3.1	-0.9	1.8	1.8	-1.4
Time employed in main current job	1.8	2.1	5.4	0.1	-1.5	-2.3	0.8
Pulse wave reflection index	1.8	2.3	5.8	1.6	0.1	0.9	2.4
Had menopause	1.7	2.2	5.0	0.2	1.9	-2.2	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	4.5	-2.1	0.1	1.5	-0.9
Supplements: Calcium	1.7	1.8	5.5	2.3	1.0	0.7	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	7.8	-1.1	1.8	2.8	-1.7
Number of full brothers	1.6	2.0	6.9	-0.7	2.6	-0.6	-0.6
Medication: Aspirin	1.6	2.1	3.9	-1.7	0.6	-2.0	-1.0
Medication: Atorvastatin	1.6	2.0	3.2	-1.3	1.8	0.8	-1.6
Medication: Co-codamol	1.5	1.7	4.7	-1.3	2.2	-0.2	-0.7
Financial difficulties in last 2 years	1.5	2.1	6.2	-1.4	0.1	2.5	-0.1
Rheumatoid Arthritis	1.4	1.9	6.7	-0.3	0.8	2.6	-0.5
Blood White Count	1.4	10.2	23.7	-4.9	-2.4	2.6	-2.1
Heel T-Score	1.4	11.0	21.3	-2.4	4.6	2.7	-3.1
Impedance of leg (left)	1.4	6.7	16.5	4.1	-1.9	2.3	1.1
Depression (self-reported)	1.4	1.6	3.7	-0.2	-1.0	1.3	-1.9
Wheeze or whistling in the chest in last year	1.4	2.5	5.0	-2.2	1.1	1.5	-1.3
Medication: Lisinopril	1.4	1.7	5.8	-2.4	0.2	-0.8	0.7
Impedance of leg (right)	1.3	6.2	16.3	4.0	-1.8	2.2	0.5
Townsend deprivation index at recruitment	1.3	1.9	3.9	-0.4	0.7	1.8	2.0
Mouth/teeth dental problems	1.3	1.9	5.0	2.2	-1.6	0.1	0.4
Chest pain or discomfort	1.3	1.8	3.1	-1.8	1.3	1.6	0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.4	3.6	1.4	-0.0	1.9	0.5
Mood swings	1.3	2.3	4.1	-1.2	2.0	1.3	-1.5
Loneliness, isolation	1.3	1.7	3.5	0.6	1.9	1.1	1.4
Depressed Affect (Nagel 2018)	1.2	2.4	7.3	-0.0	2.7	1.4	-0.6
HbA1C	1.2	1.3	2.6	-1.6	-0.6	-1.5	-0.0
Waist Hip Ratio (WHR)	1.2	5.4	11.6	3.4	-0.4	2.1	2.4
Average weekly spirits intake	1.2	1.5	5.5	-0.5	0.6	2.3	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.7	-0.5	-1.1	0.7	-1.9
Breastfed as a baby	1.2	1.5	3.0	1.5	1.7	-0.6	0.8
Arm predicted mass (right)	1.2	6.2	15.2	-3.9	-1.5	-2.7	0.6
Family relationship satisfaction	1.2	1.4	4.6	-0.5	0.8	-2.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.7	-2.4	1.4	-1.4	-0.9
Pain experienced in last month	1.2	2.0	6.9	2.6	-0.2	0.4	0.9
Alcohol drinker status: Previous	1.2	1.3	3.4	-0.4	1.8	-1.1	0.7
Intelligence (Savage-Jansen 2018)	1.1	3.3	9.5	1.2	0.5	-1.4	3.1
Blood Platelet Count	1.1	12.6	42.2	-0.8	2.7	6.5	-0.4
Ever had hysterectomy (womb removed)	1.1	1.2	2.5	1.6	1.0	-0.2	1.2
Vitamin and mineral supplements	1.1	1.5	2.4	-0.7	0.8	1.6	1.5
Multivitamins +/- minerals	1.1	1.4	4.8	-0.4	-0.4	-2.2	-0.7
Hair/balding pattern: Pattern 2	1.1	1.4	3.0	-0.2	1.1	1.7	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	6.3	-0.6	1.4	2.5	-1.4
Father’s age at death	1.1	1.4	2.5	1.0	1.6	-0.9	1.2
Medication: Lansoprazole	1.1	1.3	1.9	-1.3	-1.3	0.4	-1.4
Arm fat-free mass (right)	1.1	5.7	14.2	-3.8	-1.4	-2.4	0.9
Medication: Blood pressure	1.1	1.9	3.2	-1.6	0.7	-1.2	1.8
Medication: Ibuprofen	1.1	1.3	2.5	-1.4	1.6	0.5	0.8
Pulse rate, automated reading	1.1	3.6	7.9	-2.8	0.5	2.4	0.4
Eye problems/disorders: Cataract	1.1	1.2	4.8	0.2	2.2	-0.3	-0.1
Diastolic blood pressure, automated reading	1.1	3.4	5.4	2.3	-1.8	1.8	1.4
Schizophrenia vs Biploar Disorder	1.0	1.4	3.0	-1.7	-0.9	0.5	-1.2
Maternal smoking around birth	1.0	1.5	4.9	-0.4	-0.6	0.8	2.2
Trunk fat-free mass	1.0	5.5	15.2	-3.9	-0.6	-2.6	-0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.2	-1.2	1.5	0.5	-1.1
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.8	-0.3	-0.4	0.9	2.0
Medication: Gliclazide	1.0	1.1	2.0	0.8	-1.2	0.6	-1.4
Average weekly champagne plus white wine intake	1.0	1.3	2.2	-1.5	1.4	-0.7	-0.9
Arm fat-free mass (left)	1.0	5.3	14.4	-3.8	-0.6	-2.2	1.2
Irritability	1.0	1.8	3.3	-1.8	1.6	0.7	-0.9
Risk taking	1.0	1.5	3.3	-0.9	1.2	1.8	-0.7
Arm predicted mass (left)	1.0	5.1	12.8	-3.6	-0.8	-2.4	0.9
Alzheimer’s Disease (in father)	0.9	1.0	2.8	1.0	0.0	-0.5	1.7
Alzheimer’s Disease (including proxy)	0.9	1.3	3.0	1.2	0.2	0.8	1.7
Fasting Glucose	0.9	1.1	2.0	-1.1	-1.1	-1.4	-0.3
HDL Cholesterol	0.9	1.4	3.7	1.1	1.9	0.5	0.7
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.9	1.3	-1.7	-1.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.2	-0.2	-1.4	1.5	0.3
Pain all over the body in last month	0.9	1.0	2.6	-1.6	0.7	-0.9	0.1
Hair/balding pattern: Pattern 3	0.9	1.4	2.8	-1.7	-0.4	0.7	-1.5
Trunk predicted mass	0.9	5.4	14.7	-3.8	-0.5	-2.6	-0.0
Birth weight of first child	0.9	1.7	4.5	1.4	-0.1	0.5	2.1
Headache pain in last month	0.9	1.5	2.9	-1.7	0.5	0.7	-1.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.0	-0.2	-1.2	-2.2	-0.3
Emphysema/chronic bronchitis	0.9	1.0	2.7	-1.7	0.4	-0.1	-1.1
Overall health rating	0.9	1.9	3.1	-1.4	1.0	1.8	-1.1
Leg pain on walking	0.9	1.1	3.1	-0.7	1.8	0.2	-0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.6	0.2	1.3	-1.1	1.2
Medication: Aspirin	0.9	1.2	3.2	-1.1	0.2	-1.8	-0.6
Ever taken oral contraceptive pill	0.9	1.0	1.9	-0.2	1.0	1.4	1.0
Number of operations (self-reported)	0.9	1.3	4.7	0.6	2.2	-0.4	-0.3
Commuting to job workplace: Cycle	0.9	1.1	3.8	0.2	-1.9	-0.8	-0.4
Heart disease (siblings)	0.9	1.1	3.9	-0.4	-2.0	-0.5	-0.5
Prostate Cancer	0.8	1.1	4.0	0.1	-0.6	-2.0	0.1
Lung FVC	0.8	4.2	10.7	-3.3	0.6	-2.1	-1.2
Chronotype (morning person)	0.8	1.8	5.4	2.3	-0.0	0.9	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.3	0.2	0.4	-0.0	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.5	-0.7	0.2	0.1	-2.1
Fluid intelligence score	0.8	1.7	4.0	0.5	1.5	-0.6	2.0
Worrier / anxious feelings	0.8	1.6	4.7	-0.1	-1.2	-0.2	-2.2
Medication: Paracetamol	0.8	1.3	2.3	-0.8	1.5	1.5	0.1
Number of children fathered	0.8	0.9	2.2	-1.1	1.5	0.5	-0.1
Qualifications: College or University degree	0.8	2.6	5.9	2.0	-0.8	-2.4	-0.3
Medication for pain relief, constipation, heartburn	0.8	1.4	3.5	1.9	-1.4	-0.5	0.1
Medication: Allopurinol	0.8	1.1	2.9	-0.8	0.7	0.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.5	0.8	-1.4	-1.9	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.1	0.0	0.2	-1.1	-1.5
Whole body water mass	0.8	4.5	11.6	-3.4	-0.4	-2.4	0.5
Age started oral contraceptive pill	0.8	0.9	2.4	-0.4	-0.2	-1.1	1.6
Neuroticism (Nagel 2018)	0.7	1.7	4.0	-0.5	2.0	0.3	-1.6
Hypothyroidism (self reported)	0.7	1.7	4.1	-0.2	-2.0	-1.6	-0.3
Sensitivity / hurt feelings	0.7	1.2	3.1	-1.1	0.4	0.4	-1.8
Systolic blood pressure, automated reading	0.7	2.1	6.2	-2.5	-0.4	-0.6	1.3
Medication: Metformin	0.7	1.0	2.7	0.8	-0.6	-0.3	1.6
Fed-up feelings	0.7	1.3	3.7	0.9	0.4	1.9	0.6
Relative age voice broke	0.7	1.1	3.0	0.1	-1.2	-0.2	-1.7
Age when periods started (menarche)	0.7	1.7	5.9	-0.7	-2.4	0.0	-0.5
Supplements: Glucosamine	0.7	0.9	2.1	0.9	0.9	-1.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.6	-0.1	-0.5	0.7	-1.6
Heart attack	0.7	0.9	3.1	-0.3	-0.4	-1.8	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.0	0.5	0.9	-0.8	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.9	-1.0	1.4	0.7	0.4
Prospective memory result	0.7	0.9	2.1	-0.7	0.8	1.5	-0.5
Exposure to tobacco smoke at home	0.7	0.8	1.4	-1.2	-0.6	-0.4	1.1
Whole body fat-free mass	0.7	4.3	11.0	-3.3	-0.5	-2.4	0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.6	-0.9	0.5	-0.8	1.6
Back pain experienced in last month	0.7	1.0	3.8	-2.0	0.2	-0.1	-0.2
Osteoarthritis (self-reported)	0.7	0.9	1.1	-1.0	0.7	1.0	1.0
Commuting to job workplace: Public transport	0.7	0.8	2.5	0.4	0.3	-1.6	-0.6
Medication: Paracetamol	0.7	1.2	2.5	-0.6	1.6	1.3	0.0
Basal metabolic rate	0.7	3.7	9.6	-3.1	-0.5	-2.1	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.8	3.0	-0.2	-0.3	-1.7	-0.5
Depression (Nagel 2018)	0.6	0.8	1.2	0.7	1.1	0.6	-1.1
Age at First Birth	0.6	0.9	1.9	1.1	-0.2	-1.4	0.7
Schizophrenia (2014)	0.6	1.3	2.1	-1.4	1.1	0.3	-1.4
Triglycerides	0.6	1.0	2.8	-0.2	-1.7	0.1	1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.2	0.0	0.8	-0.1	1.5
Taking other prescription medications	0.6	1.0	2.6	-1.1	-0.3	0.4	-1.6
Serious illness, injury or assault to yourself	0.6	0.7	1.9	-0.1	-1.4	0.5	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.9	-1.1	-1.1	-1.7	0.3
Medication: Atenolol	0.6	0.8	1.4	1.2	1.0	0.8	-0.2
Number of incorrect matches in round	0.6	1.0	2.7	0.1	-0.2	1.6	-1.1
Alcohol usually taken with meals	0.6	1.0	2.8	-0.9	0.2	0.6	-1.7
Had other major operations	0.6	0.8	1.9	1.4	0.4	-0.8	0.6
Forced vital capacity (FVC)	0.6	2.4	7.8	-0.9	-0.9	-2.8	0.5
Allergy	0.6	1.4	2.9	1.7	0.9	1.3	-0.3
Medication: Ramipril	0.6	0.8	1.9	0.5	1.0	-0.2	1.4
Falls in the last year	0.6	0.8	1.9	0.3	0.9	0.6	-1.4
Noisy workplace	0.6	0.8	2.2	-0.6	1.5	0.6	-0.3
Hair/balding pattern: Pattern 4	0.6	1.4	4.0	-0.6	-1.1	-2.0	-0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.3	0.3	-0.4	1.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.9	1.4	-1.2	-0.3	0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	1.2	-0.5	0.4	1.0
Worry too long after embarrassment	0.6	1.1	2.1	0.1	1.4	-0.2	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.1	0.6	-0.6	-1.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	-0.6	-0.5	-1.4	-0.5
Alcohol intake frequency.	0.6	1.5	4.0	-1.1	-0.0	-2.0	0.9
Leg fat-free mass (right)	0.6	3.0	6.0	-2.5	-0.2	-2.2	1.1
Medication for cholesterol	0.6	1.0	3.2	-0.7	1.8	-0.2	-0.1
Leg predicted mass (right)	0.6	3.0	5.9	-2.4	-0.2	-2.2	1.2
Miserableness	0.6	1.0	2.9	-0.0	1.1	1.7	0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.9	0.5	-0.3	-1.4	0.8
Alcohol drinker status: Never	0.6	0.7	1.6	-1.3	0.3	-1.0	-0.2
Unable to work because of sickness or disability	0.6	0.7	1.9	-0.4	-0.9	1.4	-0.3
LDL Cholesterol	0.5	0.7	1.2	-0.7	0.9	1.1	0.7
Primary Biliary Cirrhosis	0.5	0.7	1.6	1.2	0.5	0.9	-0.4
BMI	0.5	2.7	7.5	-2.7	0.5	-1.4	1.1
Hand grip strength (left)	0.5	1.3	2.3	-1.2	-1.5	0.1	-1.1
Relative age of first facial hair	0.5	1.0	1.8	0.4	-0.9	1.1	-1.3
Diabetes (father)	0.5	0.6	1.9	0.1	-0.7	-0.0	1.4
Leg fat-free mass (left)	0.5	2.8	5.8	-2.4	-0.4	-2.1	1.1
Trunk fat percentage	0.5	2.2	6.5	1.5	-0.2	-0.2	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.7	1.3	-0.2	1.1	-0.1
Stomach or abdominal pain in last month	0.5	0.6	1.7	-1.3	0.4	0.6	-0.1
Sitting height	0.5	3.8	7.3	-2.4	-1.4	-2.7	0.6
Leg predicted mass (left)	0.5	2.7	5.5	-2.3	-0.3	-2.1	1.0
Qualifications: None of the above	0.5	1.0	4.0	-0.1	0.2	2.0	0.1
Weight	0.5	2.3	4.4	-2.1	-0.4	-1.6	1.4
Hip circumference	0.5	2.0	5.4	-1.1	0.5	-2.3	1.1
Pulse rate	0.5	0.8	1.9	-1.0	0.4	1.4	0.1
Mouth/teeth dental problems: Dentures	0.5	0.9	2.1	-1.4	0.3	0.8	0.8
Medication: Cholesterol lowering	0.5	0.7	1.4	-0.7	0.5	-1.2	-0.9
Blood clot in the leg (DVT)	0.5	0.7	2.0	-0.1	0.7	-1.4	0.6
Gout (self-reported)	0.5	0.7	2.6	-0.5	0.1	-0.2	-1.6
Birth weight	0.5	1.2	3.6	1.9	0.8	0.5	-0.3
Body fat percentage	0.5	1.9	6.4	1.1	-0.0	-0.1	2.5
Exposure to tobacco smoke outside home	0.5	0.6	2.0	-0.5	-0.3	1.4	-0.5
Comparative body size at age 10	0.5	1.5	3.0	-0.6	1.7	-1.0	1.2
Health satisfaction	0.5	0.6	1.6	-1.3	0.9	0.2	-0.1
Eye problems/disorders: None of the above	0.5	0.6	0.9	0.3	-0.9	0.9	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	2.1	-1.4	0.1	0.3	0.2
Supplements: Vitamin C	0.5	0.6	2.3	0.3	-0.1	-0.3	-1.5
Knee pain experienced in last month	0.5	0.8	2.0	0.9	0.5	0.3	1.4
Illnesses of father: Heart disease	0.5	0.6	1.6	-0.7	-1.3	-0.5	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.5	0.9	-1.2	0.0	0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.8	1.1	0.6	1.3	0.1
Qualifications: nursing, teaching	0.5	0.8	1.3	0.9	1.1	-1.0	0.2
Breast cancer (self-reported)	0.5	0.6	1.2	0.5	1.1	1.0	0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-0.4	1.3	-0.2	-0.8
Myopia	0.5	0.8	1.8	0.9	1.3	0.7	-0.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.0	-0.6	1.0	0.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.1	0.6	-1.3	0.7
Bipolar Disorder (2018)	0.4	0.6	2.0	-0.0	1.4	-0.5	0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	-1.0	1.5	-0.4	-0.7
Schizophrenia (2018)	0.4	0.9	1.6	-1.3	0.8	-0.1	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.8	-0.7	0.8	-1.4	1.0
Ovarian Cancer	0.4	0.5	1.0	0.3	0.6	-1.0	-0.7
Bipolar Disorder (2011)	0.4	0.3	0.7	-0.1	0.8	0.8	0.1
Neuroticism (2016)	0.4	0.6	1.7	-1.3	0.7	-0.1	-0.4
Systolic Blood Pressure	0.4	1.9	6.5	-2.5	-0.5	-0.5	0.9
Allergy or Eczema	0.4	1.1	1.9	-1.2	-1.4	-0.9	0.1
Lung FEV1/FVC ratio	0.4	2.2	6.0	0.0	1.4	2.4	-0.8
Neuroticism	0.4	1.1	3.5	-0.3	1.9	0.8	-0.2
Hearing difficulty/problems: Yes	0.4	0.7	1.7	1.0	-0.2	-0.1	1.3
Pack years adult smoking proportion	0.4	0.6	1.6	-1.3	-0.0	0.7	0.7
Current tobacco smoking	0.4	0.6	1.5	-0.8	0.1	1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	1.1	-1.0	0.1	0.2
Medication: Levothyroxine sodium	0.4	0.8	2.2	-0.9	-0.2	-1.5	0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	0.6	0.1	1.2	0.2
High blood pressure (mother)	0.4	0.6	2.1	0.1	-0.5	-0.0	-1.4
Body mass index (BMI)	0.4	1.8	5.1	-2.3	0.4	-0.7	1.1
Hearing difficulty/problems with background noise	0.4	0.6	2.0	-0.3	-0.5	-1.4	0.3
Diabetes (self-reported)	0.4	0.6	2.1	1.5	-0.2	-0.6	-0.2
Arm fat percentage (right)	0.4	1.4	4.5	0.6	0.8	-0.4	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.5	-1.1	-0.2	-1.9	-0.2
Length of working week for main job	0.4	0.4	0.9	0.1	0.3	0.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	-0.1	-0.7	1.0	-0.9
High blood pressure (siblings)	0.4	0.5	1.0	-1.0	0.9	0.4	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	-0.5	0.7	0.4	-1.1
Pulse wave peak to peak time	0.4	0.4	1.0	-0.6	-0.5	-1.0	-0.3
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.2	-0.7	1.0	-0.8
Neck or shoulder pain in last month	0.4	0.6	2.1	0.0	-0.0	0.4	1.4
Ever had bowel cancer screening	0.4	0.5	1.1	0.2	0.9	-0.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.9	0.3	-0.8	0.6
Arm fat mass (left)	0.4	1.4	4.5	-0.7	0.2	-0.8	2.1
Number of self-reported non-cancer illnesses	0.4	0.6	0.9	-1.0	0.9	-0.1	-0.9
Guilty feelings	0.4	0.5	1.1	-0.2	0.0	-1.0	-1.0
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.6	-1.0	0.7	0.5
Average weekly beer plus cider intake	0.4	0.6	1.6	-0.4	-0.6	1.3	0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.3	-0.1	-0.6	1.2	0.1
Pack years of smoking	0.4	0.6	1.6	-1.2	0.2	0.6	0.8
Leg fat mass (left)	0.4	1.4	4.6	-1.0	-0.4	-0.4	2.1
Crohns Disease (2017)	0.3	0.8	2.1	-0.4	0.7	-0.5	-1.5
Irritable Bowel Disease (IBD)	0.3	0.7	2.4	0.4	0.4	0.2	-1.5
Ulcerative Colitis (UC)	0.3	0.6	1.4	0.6	0.3	0.7	-1.2
Blood Red Count	0.3	3.1	9.5	0.6	-3.1	1.5	-0.4
Smoking Status	0.3	0.7	1.3	-0.6	-1.0	1.2	-0.4
Respiratory disease	0.3	0.7	1.7	-1.3	0.8	0.4	-0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	0.8	0.1	1.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.4	0.2	-0.0	-0.5	-1.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	0.1	-1.1	-0.6	0.3
Angina	0.3	0.5	1.1	0.1	0.0	-0.8	1.1
Supplements: Zinc	0.3	0.3	0.5	0.6	-0.3	-0.7	0.4
Hand grip strength (right)	0.3	0.7	1.3	-0.9	-1.1	0.6	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.3	-1.0	0.2	-0.7
Trunk fat mass	0.3	1.5	5.2	0.0	-0.4	-0.8	2.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	3.7	-0.9	-0.5	-1.9	0.2
Asthma	0.3	0.6	1.2	-1.1	-0.4	-0.4	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.8	0.7	0.3	0.9	0.2
Arm fat mass (right)	0.3	1.3	4.4	-0.5	0.4	-0.8	2.1
Standing height	0.3	2.6	5.2	0.2	-2.1	-2.3	0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	4.3	-0.5	-0.7	-2.1	-0.1
Age at first live birth	0.3	0.6	1.6	1.2	-0.8	0.0	-0.2
Angina (self-reported)	0.3	0.4	1.1	0.1	0.3	-0.5	1.0
Heart disease (mother)	0.3	0.3	0.7	-0.5	-0.8	-0.1	0.6
Whole body fat mass	0.3	1.3	4.9	-0.2	-0.2	-0.6	2.2
Leg fat mass (right)	0.3	1.2	4.0	-0.6	-0.3	-0.3	2.0
Number of full sisters	0.3	0.4	0.8	0.4	-0.9	0.8	-0.4
Had major operations	0.3	0.3	0.8	-0.1	0.9	0.3	-0.5
Arm fat percentage (left)	0.3	1.1	3.8	0.4	0.6	-0.2	1.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.3	-0.4	0.9	0.7
Diabetes diagnosed by doctor	0.3	0.4	0.8	0.9	-0.5	-0.8	0.3
Friendships satisfaction	0.3	0.4	1.0	0.1	-0.6	-1.0	-0.4
Asthma (self-reported)	0.3	0.6	1.4	-1.2	-0.4	-0.5	-0.7
Smoking status: Current	0.3	0.4	1.5	-0.2	0.1	1.2	-0.4
Wears glasses or contact lenses	0.3	0.4	0.9	-0.5	0.6	0.1	-1.0
Hearing aid user	0.3	0.4	0.7	0.8	0.3	0.8	0.4
Financial situation satisfaction	0.3	0.4	0.8	-0.9	-0.4	0.6	0.5
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	-0.2	-0.3	0.0	1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.5	-0.6	0.4	0.7	0.7
High cholesterol (Self-reported)	0.3	0.5	1.5	-0.5	1.2	-0.1	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.6	-0.0	0.0	0.7
Major Depression (MDD)	0.2	0.2	0.5	-0.7	-0.0	0.6	0.2
Reaction Time	0.2	0.4	0.8	0.6	0.5	-0.9	0.5
Lupus	0.2	0.3	0.6	0.3	0.6	-0.1	-0.8
Blood Eosinophil Count	0.2	1.8	4.3	-2.1	0.9	-1.2	-1.0
Number of treatments/medications taken	0.2	0.3	0.7	-0.9	0.2	0.7	-0.3
High blood pressure	0.2	0.6	1.9	-1.4	0.6	-0.1	0.3
Waist circumference	0.2	0.8	2.4	-0.3	0.1	-0.7	1.6
Past tobacco smoking	0.2	0.3	1.0	-0.0	0.4	-0.5	1.0
Medication: Simvastatin	0.2	0.3	1.1	0.0	0.4	-1.1	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.5	0.2	0.2	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.2	0.8	0.9	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.6	0.4	-0.5	-0.8	-0.6
Illnesses of mother	0.2	0.2	0.7	0.1	0.8	-0.0	0.5
Peak expiratory flow (PEF)	0.2	0.5	1.8	-0.5	-0.1	-1.3	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.8	-0.3	0.9	-0.1
Glaucoma (self-reported)	0.2	0.3	0.8	0.3	0.3	0.1	0.9
Medication: Omeprazole	0.2	0.2	0.7	-0.3	-0.8	-0.2	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.4	-0.6	0.3	-0.5
Mean time to correctly identify matches	0.2	0.5	0.8	0.9	0.8	-0.4	0.5
Comparative height size at age 10	0.2	1.4	4.0	0.4	1.0	-2.0	0.5
Suffer from ‘nerves’	0.2	0.3	1.1	1.0	-0.3	-0.0	-0.3
Age at last live birth	0.2	0.3	0.9	1.0	0.4	-0.4	-0.3
Hypertension (Self-reported)	0.2	0.5	1.8	-1.4	0.2	-0.1	0.4
Smoking status: Previous	0.2	0.3	0.7	0.1	-0.8	0.2	-0.7
Mineral and other dietary supplements	0.2	0.3	0.7	-0.8	-0.2	0.1	-0.6
Mother’s age at death	0.2	0.3	0.9	-0.1	0.2	0.5	-0.9
Medication: Blood pressure	0.2	0.5	0.8	0.7	-0.5	0.9	-0.5
Leg fat percentage (left)	0.2	0.7	2.4	-0.6	-0.1	0.4	1.5
Ever depressed for a whole week	0.2	0.3	0.5	0.7	-0.4	-0.1	0.7
Worry (Nagel 2018)	0.1	0.3	0.9	-0.1	0.2	-0.5	-0.9
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	-0.3	-0.2	-0.1	-0.4
Coronary Artery Disease (CAD)	0.1	0.2	0.4	-0.1	0.2	-0.7	-0.4
Crohns Disease (2012)	0.1	0.2	0.4	-0.1	-0.5	-0.4	-0.7
Ulcerative Colitis	0.1	0.2	0.5	0.7	-0.2	0.4	-0.3
Height	0.1	2.8	7.9	-0.3	-1.7	-2.8	0.2
Cardiovascular Disease	0.1	0.2	0.5	-0.1	0.3	0.3	0.7
Hair Pigment	0.1	2.3	4.8	0.5	-2.2	2.0	-0.2
Tanning	0.1	0.7	2.6	0.1	-0.5	-1.6	-0.0
Medication for hormone replacement therapy	0.1	0.2	0.5	0.2	-0.7	-0.3	0.1
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	0.3	-0.2	0.1
Nervous feelings	0.1	0.2	0.7	-0.2	0.1	-0.8	-0.0
Illnesses of siblings	0.1	0.2	0.4	0.6	0.2	0.2	-0.5
Neuroticism score	0.1	0.3	1.0	0.1	1.0	0.2	-0.3
Number of live births	0.1	0.2	0.2	0.4	0.5	0.4	0.2
Tense / ‘highly strung’	0.1	0.2	0.8	-0.3	0.9	0.1	-0.2
Medication: Amlodipine	0.1	0.1	0.4	-0.6	0.4	-0.2	0.0
Leg fat percentage (right)	0.1	0.5	1.6	-0.4	-0.2	0.3	1.3
Average weekly red wine intake	0.1	0.1	0.4	0.1	0.6	-0.2	0.1
Osteoporosis (self-reported)	0.1	0.2	0.4	0.4	-0.2	0.1	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.4
Ever smoked	0.1	0.2	0.7	0.1	-0.2	0.4	-0.9
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.8	0.9	-0.6	0.2	-0.1
Cholesterol lowering medication	0.1	0.1	0.4	0.6	-0.0	-0.2	0.3
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	0.2	0.2	0.2

Hub : Genes

TLN2

Models

Trait associations