Hub : Genes

TM2D2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0200	5.0e-06	0.057	0.041	0.050	0.045	0.055	1.7e-07	8.6e-06	9.4e-07	2.9e-06	2.4e-07
2	GTEx	Artery Aorta	0.0640	0.0300	7.3e-03	0.051	NA	0.011	NA	0.030	8.2e-04	NA	8.1e-02	NA	8.3e-03
3	GTEx	Artery Tibial	0.0574	0.0254	5.5e-03	0.045	NA	0.024	NA	0.030	1.9e-04	NA	5.5e-03	NA	2.1e-03
4	GTEx	Cells Transformed fibroblasts	0.0810	0.0320	1.9e-03	0.067	NA	0.017	NA	0.040	9.7e-06	NA	1.9e-02	NA	5.1e-04
5	GTEx	Esophagus Muscularis	0.1310	0.0420	2.1e-04	0.092	NA	0.102	NA	0.110	3.4e-06	NA	9.4e-07	NA	3.6e-07
6	GTEx	Muscle Skeletal	0.0655	0.0280	1.2e-03	0.067	NA	0.044	NA	0.056	4.0e-07	NA	3.4e-05	NA	3.4e-06
7	GTEx	Nerve Tibial	0.1045	0.0362	7.5e-05	0.059	NA	0.046	NA	0.047	5.5e-05	NA	3.5e-04	NA	3.0e-04
8	GTEx	Thyroid	0.0610	0.0270	5.9e-03	0.002	NA	0.004	NA	-0.001	2.1e-01	NA	1.5e-01	NA	3.6e-01
9	GTEx	Whole Blood	0.1600	0.0500	1.9e-06	0.053	NA	0.088	NA	0.064	1.1e-05	NA	1.7e-08	NA	1.6e-06
10	NTR	Blood	0.0167	0.0079	7.1e-03	0.000	0.001	0.001	0.001	0.001	3.2e-01	2.0e-01	1.1e-01	1.1e-01	1.3e-01
11	TCGA	Brain Lower Grade Glioma	0.0632	0.0294	3.2e-08	0.066	0.072	0.067	NA	0.079	5.1e-08	1.4e-08	4.9e-08	NA	2.9e-09
12	TCGA	Thyroid Carcinoma	0.1470	0.0680	2.0e-08	0.076	0.074	0.076	NA	0.084	7.8e-08	9.8e-08	7.5e-08	NA	1.5e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.0	1.6	7.1	1.2	1.0	1.4	0.7	1.4	-0.2	1.9	2.7	0.5	-1.3	-0.0	0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	0.1	-0.3	-0.1	-1.1	-0.3	-0.6	0.0	0.2	0.6	0.7	-0.5	-1.2
Depressed Affect (Nagel 2018)	3.4	7.1	11.5	-0.3	0.0	-3.2	-3.2	-3.1	-2.5	-3.1	-2.7	2.2	2.9	-2.7	-3.4
Depression (Nagel 2018)	4.0	6.0	17.5	0.8	0.8	-2.3	-2.4	-1.8	-2.6	-1.8	-1.5	4.2	3.1	-3.2	-2.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.0	-0.2	-0.3	0.4	0.5	0.5	1.2	0.7	1.2	-1.4	0.1	0.7	0.9
Neuroticism (Nagel 2018)	2.6	6.1	10.2	-0.5	-0.5	-3.2	-3.1	-3.0	-1.9	-3.1	-2.1	1.7	2.7	-2.5	-3.0
Schizophrenia (2018)	0.9	1.9	3.8	-0.9	-1.2	-1.2	-2.0	-1.5	-0.6	-1.5	-1.9	0.4	1.9	-0.7	-1.6
Schizophrenia vs Biploar Disorder	1.9	2.5	6.5	-0.8	-0.8	-1.9	-1.6	-2.4	-1.0	-2.1	-2.5	-0.5	1.4	-0.7	-1.3
Worry (Nagel 2018)	2.6	5.5	10.4	-1.3	-1.2	-3.1	-3.1	-3.0	-1.5	-3.2	-2.1	0.7	2.3	-1.8	-2.9
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.8	-0.9	0.0	-0.2	-0.3	0.5	-0.2	-0.5	-0.9	-0.4	0.6	0.1
Alzheimer’s Disease (in father)	1.3	1.4	2.8	-0.1	0.5	1.2	1.5	1.2	1.2	0.8	1.7	-1.2	-0.9	1.3	1.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	-1.1	-0.6	0.6	-0.2	-0.3	0.5	-0.4	0.1	-1.0	-0.7	0.8	0.3
Crohns Disease (2017)	0.1	0.2	1.7	0.4	0.2	0.5	0.3	0.4	-0.0	0.5	0.0	-1.3	-0.2	0.0	0.3
Irritable Bowel Disease (IBD)	0.2	0.6	2.0	0.6	0.2	1.0	0.7	1.0	0.3	1.2	0.2	-1.4	-0.1	0.5	0.6
Ulcerative Colitis (UC)	0.6	1.0	2.8	0.7	0.1	1.4	1.0	1.5	0.6	1.7	0.3	-1.3	-0.4	0.9	0.9
Major Depression (MDD)	0.4	0.5	1.8	0.8	1.0	0.6	0.6	0.8	-0.3	1.3	-0.1	0.9	-0.4	0.3	0.2
Reaction Time	0.7	1.3	3.9	-1.1	-2.0	0.1	0.4	0.2	1.9	0.8	-0.2	-1.5	-0.5	1.5	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	1.0	0.4	0.3	0.3	0.3	0.5	0.1	0.2	-0.0	-0.5	1.0	-0.4	0.1
Breast Cancer	0.2	0.4	1.8	-0.1	0.5	0.2	0.9	-0.0	0.2	-0.5	-0.2	1.3	0.3	0.3	1.1
Ovarian Cancer	0.2	0.2	1.1	0.2	0.4	0.3	0.2	0.1	0.1	-0.1	0.8	1.1	0.1	-0.6	0.2
Prostate Cancer	0.7	1.0	3.0	-1.0	-0.8	-0.8	-1.2	-1.3	0.3	-0.7	-1.7	-0.5	-1.3	0.1	-0.8
Age at First Birth	0.5	0.7	1.6	1.3	1.1	1.0	0.6	1.1	-0.6	1.2	-0.4	-0.3	-0.8	-0.2	0.0
Bipolar Disorder (2011)	0.1	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.6
Body Mass Index (BMI) (2010)	0.7	1.0	2.2	0.8	1.5	-0.3	-0.4	-0.6	-1.5	-0.6	-1.0	1.5	0.7	-1.3	-0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.6	0.7	0.9	0.4	0.4	-0.2	0.2	0.3	0.5	-0.4	-0.0	0.1
Crohns Disease (2012)	0.1	0.1	0.6	-0.2	-0.5	-0.1	0.2	-0.2	0.3	-0.3	-0.2	-0.8	-0.2	0.3	0.3
Mean Putamen Volume	0.9	1.0	5.4	0.9	0.9	1.0	0.7	0.9	-0.1	1.2	0.1	2.3	1.2	0.1	0.6
Fasting Glucose	0.2	0.2	0.7	-0.9	-0.6	-0.2	-0.5	-0.2	0.5	0.0	-0.2	-0.4	0.2	0.6	-0.5
HbA1C	1.0	1.1	3.7	1.9	0.9	0.1	-0.1	0.7	-1.5	0.4	0.3	0.9	-0.4	-1.9	0.8
HDL Cholesterol	0.1	0.2	0.9	0.5	-0.0	0.3	0.2	0.3	0.0	0.3	-0.6	-0.3	-0.9	0.1	0.1
LDL Cholesterol	0.4	0.6	1.5	1.1	1.2	0.6	0.8	0.8	-0.5	0.7	-0.5	1.2	-0.5	0.2	0.3
Lupus	0.4	0.6	2.3	-1.0	-0.8	-0.1	-0.2	-0.4	0.9	-0.0	-0.2	-1.5	-1.3	0.9	0.2
Neuroticism (2016)	0.8	1.2	3.1	1.2	1.6	-0.7	-0.2	-0.0	-1.7	-1.0	0.0	1.0	0.8	-1.8	-0.9
Primary Biliary Cirrhosis	0.7	0.9	3.0	1.0	0.6	1.1	1.3	1.7	0.3	1.1	0.2	0.2	-1.2	0.0	1.0
Rheumatoid Arthritis	1.5	2.0	3.6	-1.1	-1.3	-1.7	-1.6	-1.7	-0.6	-1.9	-0.3	1.8	1.8	-0.8	-1.4
Schizophrenia (2014)	0.4	0.9	3.1	-0.7	-1.1	-0.8	-1.2	-0.9	-0.4	-0.9	-1.0	-0.1	1.8	-0.2	-1.1
Triglycerides	1.1	1.8	5.2	-0.3	-0.1	1.1	1.3	1.2	1.3	1.4	2.3	-1.0	-1.5	1.6	1.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	-1.2	-0.6	-1.2	-1.0	-1.1	-0.2	-0.8	1.1	-0.3	0.9	0.2	-0.6
Ulcerative Colitis	1.0	1.5	4.3	0.6	-0.2	1.8	1.3	1.6	0.9	2.1	0.8	-0.7	-0.2	1.3	1.2
Blood Eosinophil Count	0.6	4.7	11.8	-3.0	-3.4	0.0	0.1	-0.7	3.4	-0.4	1.9	-2.6	-0.9	3.2	1.4
Blood Platelet Count	1.1	12.3	24.7	-4.3	-5.0	-4.5	-4.3	-4.2	0.7	-4.0	-3.9	-1.9	1.2	0.1	-3.3
Blood Red Count	1.3	12.3	23.5	0.0	-0.7	4.3	4.2	4.0	3.8	4.2	3.4	-2.6	-1.5	4.4	4.8
Blood White Count	1.1	7.9	22.2	-4.7	-4.5	-1.1	-1.2	-1.5	3.5	-1.2	2.7	-3.6	0.7	3.5	0.8
Heel T-Score	0.1	0.7	1.8	1.2	1.0	1.0	0.6	1.1	-0.6	0.8	0.5	1.3	0.9	-0.2	0.1
BMI	0.7	3.8	12.8	2.9	2.9	1.2	0.8	1.0	-2.2	0.9	1.5	3.6	1.5	-1.7	-0.4
Height	1.0	18.5	32.6	1.8	1.6	5.5	5.5	5.5	3.6	5.7	4.9	-3.1	-1.8	3.3	5.7
Waist Hip Ratio (WHR)	1.5	6.8	16.8	-3.1	-3.0	0.5	0.8	0.2	4.0	0.4	2.5	-3.7	-1.9	4.1	2.3
Systolic Blood Pressure	0.5	2.3	5.1	0.1	0.6	1.8	2.1	1.2	1.2	1.7	-0.5	-1.5	-2.0	1.6	2.3
Smoking Status	0.4	0.9	4.3	0.5	-0.3	0.8	-0.0	0.7	-0.1	1.3	2.1	1.7	-0.8	0.3	-0.2
Allergy or Eczema	0.3	0.9	6.3	1.1	1.0	0.1	0.8	0.2	-0.3	0.2	0.3	0.8	2.5	-0.2	0.6
Cardiovascular Disease	1.0	3.4	6.2	-0.5	-0.6	2.1	2.0	1.9	2.2	2.2	1.4	-1.6	-1.4	2.4	2.5
Hypothyroidism (self reported)	0.2	0.3	1.0	-0.7	-0.5	-0.9	-1.0	-1.0	-0.1	-0.5	0.1	0.3	0.2	-0.3	-0.5
Respiratory disease	1.1	2.5	5.4	-0.7	-1.2	1.3	1.7	1.2	2.2	1.4	2.3	-0.8	0.6	2.3	2.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.8	-0.3	-0.1	1.0	1.0	0.8	1.2	0.8	1.1	-1.2	-1.4	0.9	1.3
Lung FEV1/FVC ratio	0.7	3.6	12.0	3.0	2.8	1.0	1.1	0.8	-1.9	0.7	1.5	3.5	1.4	-1.7	-0.0
Lung FVC	0.9	4.6	16.5	-0.1	0.7	-2.0	-1.9	-1.6	-2.2	-2.4	-4.1	1.9	1.6	-2.5	-2.2
Neuroticism	1.4	3.3	5.3	-0.0	0.1	-2.1	-2.1	-2.0	-1.9	-2.2	-1.4	1.7	2.2	-1.8	-2.3
Chronotype (morning person)	1.1	2.4	4.7	-1.6	-1.4	-2.1	-2.2	-1.9	-0.5	-2.1	-1.5	-1.0	-0.1	-0.3	-1.9
Hair Pigment	0.1	1.5	5.2	-1.6	-2.1	-0.6	-0.4	-0.6	1.4	-0.5	-0.7	-2.3	-0.4	1.3	-0.1
Tanning	0.1	0.7	2.1	0.9	0.8	-0.5	-0.5	-0.3	-1.3	-0.6	-0.4	1.0	0.7	-1.4	-0.9
Hand grip strength (left)	1.2	3.2	6.3	-0.9	-0.9	-2.3	-2.4	-2.1	-1.1	-2.5	-2.1	-0.2	1.3	-1.6	-2.2
Number of treatments/medications taken	0.3	0.5	1.0	-0.2	-0.1	0.7	0.6	0.7	0.7	1.0	0.0	-0.5	-0.9	0.9	0.8
Average weekly spirits intake	2.2	2.7	5.5	1.8	1.8	2.1	2.1	2.4	-0.3	2.3	1.4	1.5	-0.2	0.2	1.5
Sensitivity / hurt feelings	0.5	0.8	1.8	0.4	0.4	-1.0	-0.7	-1.0	-1.4	-1.3	0.4	0.9	-0.2	-1.2	-1.2
Frequency of depressed mood in last 2 weeks	1.9	2.7	7.4	1.0	0.8	-1.3	-1.4	-0.8	-2.1	-0.8	-1.3	2.7	1.5	-2.4	-1.9
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-0.1	0.2	0.5	1.0	0.6	0.7	0.1	0.9	-1.0	-0.3	0.8	1.2
Relative age of first facial hair	0.2	0.5	1.0	-0.2	-0.5	-0.8	-0.8	-0.7	-0.5	-1.0	-0.9	-0.6	0.4	-0.4	-0.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	5.1	-1.4	-1.7	0.5	0.5	0.3	2.3	0.7	1.5	-0.3	0.4	1.6	1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.6	1.4	1.6	0.8	1.1	0.4	-0.6	0.9	-0.1	0.2	-0.2	-0.3	0.7
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	-0.7	-0.1	-1.0	-0.3	-1.2	-0.2	-1.1	-0.8	-0.6	-0.2	0.4	-0.1
Systolic blood pressure, automated reading	0.5	1.3	3.6	1.5	1.9	1.4	1.5	0.8	-0.5	0.9	-0.3	0.9	-1.6	-0.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.5	-1.1	-0.6	0.2	0.4	0.1	1.2	-0.2	-0.6	-1.6	-0.4	1.5	0.8
Angina	0.7	1.0	3.3	1.7	1.8	0.7	0.9	1.0	-1.4	0.6	0.3	-0.4	-0.4	-0.6	0.1
Medication for hormone replacement therapy	0.1	0.1	0.4	-0.4	-0.1	-0.3	-0.3	-0.1	0.2	0.6	0.6	0.4	0.5	0.6	-0.1
Vitamin and mineral supplements	0.5	0.7	2.3	0.3	-0.1	1.0	0.3	1.0	0.4	1.2	1.5	-0.4	-1.5	0.5	0.2
Supplements: Zinc	0.5	0.5	2.7	-0.1	-0.2	0.1	0.1	-0.3	0.0	0.2	-1.2	-1.6	-1.4	0.3	0.4
Medication: Co-codamol	1.0	1.2	2.5	1.4	1.3	1.5	1.6	1.4	-0.2	1.3	0.4	0.4	-0.7	0.4	1.0
Medication: Metformin	0.3	0.4	0.9	0.1	0.8	0.6	0.9	0.6	0.1	0.2	0.9	0.4	-0.6	0.3	0.7
Diabetes (father)	0.3	0.4	1.0	-0.6	-0.5	-0.6	-1.0	-0.6	-0.5	-0.7	-0.2	0.9	0.6	-0.4	-0.7
Diabetes (mother)	0.6	0.7	2.0	0.7	0.8	1.2	0.9	1.1	-0.1	0.9	1.0	1.4	0.1	0.1	0.7
Severe depression (siblings)	1.1	1.3	3.6	1.2	1.1	-0.5	-0.5	-0.4	-1.9	-0.8	-0.2	0.8	1.8	-1.7	-1.2
Pack years adult smoking proportion	3.8	5.8	12.0	-2.6	-2.6	-3.4	-3.5	-3.2	-0.4	-3.1	-2.2	0.1	0.4	-0.1	-2.7
Impedance of leg (right)	1.0	5.0	18.4	-0.1	-0.2	1.8	2.3	2.2	2.5	1.7	1.5	-2.1	-4.3	2.3	2.8
Leg fat-free mass (left)	0.2	1.2	2.4	1.5	1.5	1.1	0.5	0.9	-1.0	1.2	1.0	1.4	1.2	-0.7	-0.0
Trunk fat percentage	2.4	9.8	18.1	2.2	2.1	4.3	4.0	3.9	1.2	4.2	3.9	0.8	-2.8	1.7	3.6
Hand grip strength (right)	0.5	1.3	2.6	0.4	0.1	-1.1	-1.3	-1.0	-1.3	-1.3	-0.9	0.5	1.1	-1.6	-1.6
Townsend deprivation index at recruitment	0.5	0.7	1.5	0.8	0.2	0.9	0.7	1.2	0.4	1.1	1.1	1.1	0.4	-0.1	0.8
Current tobacco smoking	0.4	0.7	2.7	-0.6	-1.2	-0.5	-1.0	-0.3	0.1	0.1	1.4	1.6	0.3	0.2	-0.7
Average weekly fortified wine intake	0.8	1.0	2.8	-1.2	-1.3	-1.2	-0.7	-1.2	0.5	-1.7	-0.1	-0.6	1.2	-0.2	-0.3
Maternal smoking around birth	0.3	0.4	0.8	-0.0	-0.4	0.5	0.7	0.9	0.5	0.8	0.8	-0.1	-0.5	0.7	0.8
Fed-up feelings	3.5	6.4	11.7	-1.0	-1.1	-3.2	-3.4	-3.0	-1.8	-2.8	-3.3	1.4	2.0	-2.0	-3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	10.3	-0.5	-0.4	-2.5	-2.5	-2.0	-1.5	-1.8	-0.4	2.6	3.2	-2.0	-2.4
Relative age voice broke	0.8	1.3	4.2	-1.8	-1.6	-0.8	-0.8	-0.7	1.1	-0.6	-0.2	-2.0	-0.3	1.3	0.1
Taking other prescription medications	0.3	0.5	2.6	0.7	0.5	0.7	0.3	0.5	-0.4	1.1	0.7	1.6	0.5	0.0	0.2
Age when periods started (menarche)	0.1	0.3	0.8	0.4	0.3	0.4	0.8	0.3	0.3	-0.1	0.9	-0.6	0.3	0.7	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	-0.7	-0.1	-1.1	-0.6	-1.1	-0.5	-0.6	-0.2	0.8	-0.3	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	3.3	1.8	1.2	1.4	0.9	1.2	-0.8	1.2	0.3	-0.4	-0.8	-0.4	0.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.9	1.7	1.8	1.8	1.8	2.0	-0.1	1.6	1.7	1.0	-0.4	-0.3	1.4
Qualifications: CSEs or equivalent	0.7	0.9	4.1	0.6	0.7	1.1	1.0	0.9	0.5	1.1	2.0	0.5	0.8	0.2	1.0
Serious illness, injury or assault to yourself	0.5	0.6	2.1	-0.7	-0.6	0.4	0.2	0.5	1.1	0.1	-0.6	-0.8	-1.4	0.9	0.6
High blood pressure	1.0	2.8	4.9	-0.0	-0.1	2.1	2.1	1.6	1.7	1.9	1.6	-0.6	-2.0	1.8	2.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	6.2	0.6	0.4	-0.6	-0.2	-0.5	-0.7	-0.7	-0.7	0.4	2.5	-0.5	-0.3
Multivitamins +/- minerals	1.4	1.8	6.1	0.9	1.1	-0.7	-0.3	-0.6	-1.6	-1.0	-2.5	1.4	2.0	-1.7	-0.7
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.8	0.9	0.9	0.5	0.8	0.0	1.1	0.2	0.7	-0.6	-0.4	0.5
Supplements: Glucosamine	0.7	1.0	3.9	0.1	-0.0	0.8	1.1	0.6	1.0	0.7	0.7	-2.0	-1.4	0.8	1.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.6	0.4	0.7	0.3	0.3	-0.1	-0.0	0.3	-0.8	-0.1	-0.3	0.2	0.0
Medication: Atenolol	1.8	2.2	5.2	0.0	0.7	1.9	2.2	1.9	1.4	1.4	1.3	-0.8	-0.6	1.5	2.3
Medication: Levothyroxine sodium	1.0	1.6	6.8	-1.7	-1.5	-0.7	-0.9	-1.1	1.0	-0.3	0.3	-1.8	-2.6	0.8	-0.1
Sitting height	0.3	2.4	5.7	2.2	2.4	1.7	1.2	2.0	-0.8	2.0	0.9	1.5	-0.9	-0.9	0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	1.1	1.1	0.8	0.5	0.4	0.5	-0.3	0.9	-0.8	-0.6	-0.1	0.2	-0.2
High blood pressure (mother)	0.9	1.3	4.4	-0.7	-0.8	1.3	0.5	1.0	1.0	1.6	0.1	-2.1	-1.2	1.4	0.7
Body mass index (BMI)	0.8	3.3	11.8	2.4	2.6	0.5	-0.1	0.1	-2.7	0.6	-0.1	3.4	1.0	-2.1	-1.2
Impedance of leg (left)	1.0	5.0	17.1	-0.7	-0.7	1.6	2.1	1.9	2.8	1.6	1.6	-2.1	-4.1	2.5	2.8
Leg predicted mass (left)	0.2	1.1	2.2	1.5	1.4	1.0	0.4	0.9	-1.0	1.1	1.0	1.4	1.3	-0.7	-0.1
Trunk fat mass	1.7	7.5	14.2	2.6	2.6	3.7	3.3	3.4	0.3	3.8	3.4	1.6	-2.0	0.8	2.6
Waist circumference	0.3	0.9	3.2	0.6	0.9	1.3	0.8	0.9	-0.0	1.4	1.8	0.6	-0.6	0.5	0.7
Number of incorrect matches in round	1.9	3.1	7.6	2.2	2.7	-0.5	-0.5	-0.6	-2.8	-0.7	0.1	2.5	0.3	-2.6	-1.8
Past tobacco smoking	0.4	0.7	3.3	0.2	0.6	-0.7	-0.2	-0.7	-0.7	-1.1	-0.9	0.5	1.8	-0.8	-0.4
Alcohol usually taken with meals	0.7	1.1	2.9	-1.5	-1.7	-0.5	-0.6	-0.7	1.4	-0.4	-1.5	-1.1	-1.0	1.0	0.1
Nervous feelings	2.0	3.8	8.5	-2.1	-1.9	-2.7	-2.5	-2.8	-0.2	-2.9	-1.6	0.2	1.3	-0.4	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	9.7	-1.3	-0.8	-2.8	-3.1	-2.6	-1.5	-2.3	-1.0	1.1	1.4	-1.6	-2.6
Hearing difficulty/problems with background noise	1.0	1.5	4.1	2.0	2.0	1.1	1.1	1.1	-1.1	0.6	1.4	1.3	0.9	-0.8	0.3
Hair/balding pattern: Pattern 2	1.0	1.3	3.9	-1.4	-1.6	-0.1	0.2	0.2	1.6	-0.0	0.8	0.4	-2.0	1.6	0.8
Had menopause	0.3	0.4	2.1	-0.6	-0.7	0.2	0.4	-0.0	0.8	0.1	0.5	1.4	-0.1	0.7	0.8
Had other major operations	0.9	1.1	3.1	0.4	0.1	1.4	1.1	1.3	0.7	1.7	0.0	0.0	-1.6	1.0	1.3
Forced vital capacity (FVC)	0.4	1.5	6.5	-0.5	-0.3	-1.5	-1.4	-0.8	-0.6	-1.5	-2.6	-0.3	0.8	-1.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	7.0	2.6	2.0	1.8	1.2	1.4	-1.4	1.3	0.5	0.9	-0.5	-1.1	0.1
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	8.6	-1.8	-2.0	-2.9	-2.0	-2.5	-0.2	-2.5	-1.8	-0.4	0.2	-0.0	-1.6
Qualifications: None of the above	0.4	0.8	1.8	-1.1	-0.6	-1.3	-1.0	-1.3	-0.3	-1.2	0.2	1.0	0.5	0.0	-0.7
Financial difficulties in last 2 years	0.5	0.6	1.3	-1.1	-0.8	-0.9	-1.1	-0.9	0.0	-0.9	-0.9	0.0	1.0	0.0	-0.4
Mouth/teeth dental problems	1.3	1.9	4.9	-0.6	-0.3	1.0	1.2	0.9	1.6	1.0	1.2	-2.2	-2.1	1.9	1.4
Heart attack	1.4	1.8	3.6	-0.6	-0.1	-1.8	-1.6	-1.6	-1.2	-1.9	-1.3	-0.3	1.0	-1.3	-1.7
Allergy	0.2	0.4	4.1	-0.1	0.4	0.4	-0.1	0.3	0.2	0.6	-0.1	0.0	-2.0	-0.1	-0.0
Pain all over the body in last month	0.8	0.9	2.8	-1.1	-1.2	0.4	0.5	0.4	1.2	-0.1	0.6	-0.2	-1.5	1.7	0.7
Diabetes (self-reported)	0.4	0.6	2.2	-0.2	0.2	0.7	0.8	0.5	0.7	0.2	0.7	-0.7	-1.5	0.8	1.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.7	1.4	1.3	0.1	-0.1	-0.1	-1.1	0.0	-1.2	0.7	1.9	-1.3	-0.3
Medication: Ramipril	0.2	0.3	1.1	-0.5	-0.8	-0.1	0.4	-0.3	0.6	-0.1	-0.2	-0.0	-1.1	0.5	0.7
Medication: Simvastatin	1.1	1.7	4.2	-0.8	-0.4	0.9	0.7	1.2	1.5	0.8	2.0	-1.4	-2.0	1.5	1.2
Fluid intelligence score	0.3	0.6	2.3	0.8	0.2	-0.5	-0.4	-0.5	-1.0	-0.7	-0.3	-0.2	1.5	-1.2	-0.8
Illnesses of siblings	0.3	0.4	1.5	-1.1	-1.2	-0.4	-0.3	-0.2	0.8	-0.6	0.2	-0.5	0.4	0.7	0.3
Neuroticism score	1.5	3.0	5.9	-0.5	-0.4	-2.3	-2.2	-2.2	-1.5	-2.4	-1.5	0.7	1.8	-1.4	-2.3
Weight	0.6	3.0	6.6	2.5	2.6	1.8	1.1	1.6	-1.4	2.1	1.5	2.5	0.1	-1.0	0.3
Impedance of arm (right)	2.7	12.8	26.1	-2.1	-2.5	2.5	3.3	2.6	5.1	2.3	3.6	-4.4	-3.4	4.7	4.7
Arm fat percentage (right)	0.7	2.8	4.3	2.0	2.0	2.0	1.8	1.7	-0.6	2.1	2.1	2.0	-0.8	-0.0	1.2
Trunk fat-free mass	0.5	2.6	6.2	1.8	2.0	-0.3	-1.0	-0.3	-2.4	-0.0	-0.7	2.5	1.7	-2.1	-1.7
Hip circumference	0.4	1.8	4.3	2.0	2.1	1.6	0.9	1.3	-1.1	1.7	0.7	1.9	-0.4	-0.7	0.2
Time employed in main current job	2.3	2.6	5.9	-0.4	-0.2	1.8	1.7	1.6	1.8	1.2	1.5	-1.2	-2.4	2.1	2.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.2	0.1	-0.5	-0.3	-0.6	-0.3	0.1	0.2	0.5	-0.5	-0.1	-0.3
Father’s age at death	1.0	1.4	4.4	2.1	1.2	0.1	0.3	0.1	-1.4	-0.1	-1.2	1.6	1.4	-1.5	-0.6
Worrier / anxious feelings	3.2	6.0	12.7	-0.8	-0.5	-3.2	-2.9	-3.1	-2.1	-3.6	-3.1	-0.1	1.6	-2.0	-3.2
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	10.0	-0.6	-0.8	-2.8	-3.2	-2.6	-1.8	-2.2	-1.0	1.9	1.4	-1.9	-3.2
Falls in the last year	0.9	1.3	3.0	0.7	0.6	1.5	1.7	1.2	0.2	0.7	1.3	-0.5	-1.7	0.7	1.4
Hair/balding pattern: Pattern 3	1.5	2.2	4.9	0.8	1.2	-0.8	-1.4	-1.0	-2.2	-1.1	-1.1	0.6	2.2	-2.1	-2.0
Number of live births	1.0	1.4	4.0	1.8	2.0	1.1	1.4	0.9	-0.6	1.3	0.0	-0.0	-1.7	-0.5	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	5.3	0.7	0.9	-1.0	-0.7	-0.3	-1.3	-1.2	-2.3	0.8	1.3	-1.7	-1.0
Pulse rate	0.3	0.5	1.2	-1.1	-1.0	-0.6	-0.5	-0.6	0.5	-0.9	-0.2	0.4	-1.1	0.4	-0.2
Happiness	0.6	0.8	3.1	-0.1	-0.4	0.6	0.7	0.9	0.7	1.0	-0.6	-1.1	-1.8	0.8	0.7
Noisy workplace	0.3	0.4	2.7	0.3	0.7	-0.4	0.4	-0.2	-0.3	-0.7	-0.1	1.7	-0.1	-0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.7	-1.1	-1.9	-0.1	0.0	0.0	1.1	0.2	-1.2	-1.6	0.5	1.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	6.7	-0.6	-0.6	-1.6	-1.5	-1.8	-0.9	-2.0	-2.6	1.1	-0.5	-1.2	-1.6
Mouth/teeth dental problems: Dentures	1.7	2.9	5.7	1.3	1.2	-0.8	-1.4	-1.2	-2.4	-1.2	-2.2	2.3	1.0	-2.1	-2.1
Asthma	1.1	2.2	5.9	-1.3	-1.6	0.8	1.3	0.8	2.2	0.9	1.7	-0.7	0.6	2.4	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.4	0.0	-0.0	-0.5	0.1	-0.4	0.3	0.7	-0.2	0.8	-0.6	-0.6
Medication: Cholesterol lowering	0.8	1.3	3.5	-1.2	-1.1	0.5	0.3	0.6	1.5	0.4	0.6	-1.5	-1.9	1.6	1.0
Depression (self-reported)	0.7	0.8	2.2	0.6	0.0	-0.9	-0.7	-0.6	-1.1	-0.8	-1.1	1.4	0.4	-1.5	-0.8
Medication: Lansoprazole	4.1	4.7	11.0	3.3	3.3	2.7	2.3	2.5	-1.3	2.4	1.3	2.1	-0.9	-0.9	1.2
Prospective memory result	0.8	1.0	2.6	-0.8	-0.7	-1.6	-1.5	-1.3	-0.5	-1.1	-0.4	1.0	-0.5	-0.6	-1.2
Lung cancer (father)	0.3	0.3	0.7	-0.2	-0.3	-0.8	-0.7	-0.6	-0.4	-0.6	-0.7	-0.1	0.8	-0.6	-0.6
Illnesses of mother	0.4	0.5	1.5	0.2	0.0	-1.2	-0.8	-0.9	-0.4	-0.8	0.4	0.6	0.5	-0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.4	1.0	0.9	-0.0	0.2	0.6	-0.8	-0.1	-1.5	0.4	0.9	-1.1	-0.0
Pulse wave Arterial Stiffness index	1.0	1.2	2.4	-0.2	-0.6	1.3	1.1	1.1	1.4	0.9	-0.9	-1.2	-1.0	1.6	1.2
Impedance of arm (left)	3.7	17.1	30.8	-1.6	-2.0	3.7	4.3	3.8	5.5	3.4	4.0	-4.6	-4.0	5.2	5.5
Arm fat mass (right)	0.6	2.6	5.8	2.3	2.3	1.7	1.2	1.4	-1.2	1.9	1.6	2.4	-0.3	-0.7	0.5
Trunk predicted mass	0.5	2.8	6.6	1.8	2.0	-0.4	-1.0	-0.4	-2.5	-0.0	-0.8	2.6	1.8	-2.1	-1.8
Standing height	0.6	6.1	10.4	0.5	0.3	3.0	2.7	3.1	2.5	3.2	3.1	-1.6	-2.0	2.3	3.0
Length of working week for main job	3.5	3.9	10.9	0.3	0.3	1.9	2.1	2.2	1.7	1.8	2.9	-0.6	-3.3	1.7	2.2
Exposure to tobacco smoke at home	0.8	0.9	1.9	1.2	1.4	0.4	0.7	0.4	-1.1	-0.7	0.3	1.4	1.0	-1.2	0.1
Breastfed as a baby	0.4	0.5	1.5	1.2	0.8	0.7	0.4	0.7	-0.4	1.2	0.3	0.9	-0.1	-0.7	0.2
Tense / ‘highly strung’	0.5	0.9	1.8	-0.8	-0.5	-1.3	-1.3	-1.4	-0.4	-1.3	-0.1	0.6	0.8	-0.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.1	-0.8	-1.2	-2.0	-1.8	-1.7	-0.8	-1.8	-1.1	0.1	0.9	-1.2	-1.7
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	1.1	0.9	0.2	0.5	0.3	-0.5	0.2	0.3	-0.6	-1.2	-0.7	0.0
Birth weight of first child	0.3	0.5	1.9	0.9	1.4	-0.5	-0.1	-0.3	-1.1	-0.5	0.4	0.2	0.7	-0.9	-0.6
Peak expiratory flow (PEF)	0.6	1.5	3.8	0.6	1.0	-0.9	-0.6	-0.4	-1.1	-1.2	-1.9	1.6	1.2	-1.8	-0.9
Pulse wave reflection index	0.2	0.2	1.1	0.5	0.0	0.4	0.2	0.4	-0.1	0.1	-1.0	-0.5	0.4	-0.4	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	0.1	-0.2	-0.3	0.1	-0.7	0.0	-0.1	0.6	0.4	-0.6	-0.5
Loud music exposure frequency	1.5	1.7	4.1	1.9	1.3	-0.7	-0.2	-0.6	-2.0	-0.4	-1.2	1.2	1.2	-1.8	-1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	0.6	-0.2	1.1	0.6	1.0	0.4	1.1	-1.1	-0.5	0.5	0.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.9	-0.8	-0.3	-0.6	-0.3	0.6	0.1	0.9	-0.3	0.8	-0.0	0.2
Blood clot in the leg (DVT)	0.5	0.6	2.1	-0.5	-1.1	-0.3	-0.5	-0.4	0.0	-0.3	-0.8	-1.4	1.5	0.3	-0.4
Medication: Paracetamol	0.3	0.5	1.6	1.0	0.9	0.5	0.4	0.5	-0.6	0.2	0.3	0.7	1.2	-0.7	-0.1
Headache pain in last month	0.0	0.1	0.3	0.0	0.2	-0.2	-0.0	-0.1	0.1	0.4	0.6	0.0	0.2	0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.7	4.4	1.2	1.0	-0.9	-0.7	-0.7	-1.7	-0.9	-0.9	1.3	2.0	-2.1	-1.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	-0.2	-0.0	0.3	-0.0	0.3	-0.2	0.3	0.0	0.5	-0.5	0.1
Gout (self-reported)	5.3	7.2	15.6	-1.0	-0.6	2.6	2.6	2.3	3.0	2.9	4.0	-2.6	-2.1	3.4	3.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.6	-0.4	-0.7	-0.9	-1.1	0.0	-0.2	0.0	0.1	-1.1	-0.2	-0.5
Medication: Amlodipine	5.1	7.2	14.1	1.2	1.4	3.8	3.7	3.4	1.9	3.4	2.8	-0.2	-1.1	2.4	3.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.3	-1.5	-1.8	-0.7	-0.5	-0.8	1.2	-0.5	-0.1	-0.1	0.6	1.4	0.1
Birth weight	0.3	0.7	2.9	1.3	1.1	0.8	0.8	0.8	-0.2	0.7	0.3	0.3	-1.7	-0.2	0.5
Chronic bronchitis/emphysema (mother)	2.6	3.1	6.4	-0.1	0.1	-2.5	-2.1	-2.2	-1.6	-2.5	-1.6	0.9	0.3	-1.8	-2.4
High blood pressure (siblings)	0.4	0.6	1.7	0.6	0.7	-0.3	-0.7	-0.4	-1.1	-0.1	-1.0	0.6	0.3	-1.3	-1.1
Forced vital capacity (FVC), Best measure	0.1	0.4	3.2	-0.2	-0.3	-0.5	-0.5	0.0	-0.1	-0.6	-1.8	-0.3	0.9	-0.4	-0.2
Body fat percentage	1.7	6.6	12.0	2.5	2.4	3.4	3.1	3.1	0.2	3.5	3.1	1.7	-2.1	0.7	2.5
Leg fat percentage (right)	1.3	4.7	12.7	3.4	3.6	1.9	1.7	1.8	-2.1	1.9	0.9	3.3	-0.9	-1.4	0.4
Arm fat-free mass (right)	0.5	2.8	8.5	2.2	2.2	0.2	-0.6	0.1	-2.5	0.6	-0.1	2.9	1.3	-2.1	-1.4
Exposure to tobacco smoke outside home	0.9	1.2	3.5	1.1	1.3	0.8	1.1	0.9	-0.5	0.8	1.9	-0.9	1.8	0.0	0.6
Comparative body size at age 10	2.1	5.8	13.9	2.9	2.6	-0.8	-0.9	-0.5	-3.5	-0.8	-0.6	3.4	2.9	-3.7	-2.4
Number of full brothers	0.2	0.2	0.7	0.8	0.8	0.5	0.2	0.6	-0.4	0.7	0.1	-0.2	-0.3	-0.4	-0.1
Worry too long after embarrassment	0.1	0.2	0.8	0.0	-0.3	-0.4	0.2	0.0	0.2	-0.7	0.3	-0.9	0.7	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	8.8	-2.4	-3.0	-2.2	-1.9	-1.9	0.8	-1.8	-0.2	-2.0	1.1	0.4	-1.1
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	0.3	0.2	-0.5	-0.6	-0.5	-1.1	-0.7	-0.0	1.1	-0.5	-0.7	-1.1
Number of children fathered	2.9	3.3	9.5	2.8	2.9	0.1	-0.1	0.1	-3.1	0.2	-0.3	2.2	0.4	-2.7	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	3.4	4.0	8.8	2.2	2.0	3.0	2.7	2.9	0.6	2.3	1.7	-0.5	0.6	-0.1	2.2
Age at first live birth	0.3	0.5	1.6	-0.4	-0.7	0.3	0.8	0.3	1.3	-0.0	-0.2	-0.9	-0.1	0.9	1.1
Pulse wave peak to peak time	0.9	1.0	2.3	0.4	0.7	-1.1	-0.9	-0.9	-1.4	-0.7	1.0	1.1	1.0	-1.5	-1.1
Health satisfaction	0.3	0.3	1.5	0.3	-0.6	0.4	0.5	0.5	0.2	0.5	-0.5	1.2	-0.8	0.2	0.5
Shortness of breath walking on level ground	1.5	1.8	4.8	0.9	1.0	-0.8	-1.0	-0.7	-2.2	-1.1	-1.7	1.2	1.5	-1.8	-1.5
Qualifications: College or University degree	0.3	0.8	5.8	-0.5	-1.1	0.1	0.1	0.4	0.8	0.3	0.6	-2.4	0.9	0.7	0.4
Eye problems/disorders: None of the above	1.5	1.7	3.7	-0.5	-0.3	-1.6	-1.9	-1.4	-1.3	-1.1	-1.7	-0.5	1.2	-1.2	-1.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.2	0.1	0.0	0.5	0.4	-0.0	-0.6	-0.5	-0.6	0.0	-0.3	0.5
Emphysema/chronic bronchitis	0.6	0.6	2.6	1.1	0.5	1.0	0.7	1.0	-0.2	0.8	0.4	-0.2	-1.6	-0.1	0.3
Medication for pain relief, constipation, heartburn	0.8	1.3	3.4	-0.4	-0.6	-1.4	-1.2	-1.4	-0.7	-1.7	-1.8	0.6	0.2	-1.0	-1.2
Neck or shoulder pain in last month	0.5	0.7	2.2	1.5	1.3	0.7	0.7	0.8	-0.9	0.4	-0.2	0.7	-0.7	-1.1	0.0
Medication: Blood pressure	0.4	0.7	2.2	-0.8	-0.7	0.5	0.7	0.2	1.2	0.5	0.7	-1.0	-0.7	1.5	1.0
Angina (self-reported)	0.9	1.2	3.9	1.7	2.0	1.0	1.3	1.3	-1.1	0.9	0.5	-0.6	-0.8	-0.3	0.5
Migraine (self-reported)	0.3	0.4	1.9	-0.1	-0.1	0.3	0.1	0.2	0.0	0.1	-1.0	-1.4	-1.1	0.3	-0.0
Medication: Ibuprofen	0.5	0.6	1.5	0.5	0.3	-0.7	-0.8	-0.5	-1.0	-0.5	0.1	-0.1	1.2	-1.1	-1.1
Medication: Allopurinol	2.6	3.4	9.9	0.2	0.6	2.0	2.1	1.8	1.3	2.2	3.2	-1.4	-1.6	1.8	2.2
Medication: Omeprazole	1.2	1.5	3.5	-0.0	0.7	1.5	1.1	1.5	0.9	1.9	1.4	-1.2	-0.6	1.1	1.4
Medication: Seretide 50 evohaler	1.2	1.4	2.7	-1.1	-1.2	-1.6	-1.5	-1.5	-0.5	-1.3	-0.9	0.8	1.0	-0.5	-1.5
Mean time to correctly identify matches	0.3	0.5	1.9	-0.8	-1.4	-0.1	0.0	-0.1	1.3	0.3	-0.5	-1.0	-0.3	0.9	0.2
Heart disease (mother)	0.6	0.7	3.6	0.6	0.7	-0.0	-0.2	0.2	-1.3	-0.0	-1.9	1.1	0.1	-0.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.2	0.2	-0.1	1.3	1.1	1.5	0.9	0.9	0.2	-1.3	-0.7	0.8	1.1
Whole body fat mass	1.2	4.9	9.5	2.5	2.5	2.9	2.4	2.6	-0.4	3.1	2.7	1.9	-1.4	0.2	1.8
Leg fat mass (right)	1.0	3.7	10.0	2.9	3.0	1.7	1.2	1.5	-1.9	1.8	1.3	3.2	-0.3	-1.3	0.2
Arm predicted mass (right)	0.6	2.9	8.3	2.5	2.5	0.6	-0.1	0.5	-2.4	1.1	0.2	2.9	1.2	-2.0	-1.0
Pulse rate, automated reading	1.2	3.9	9.0	-1.2	-0.9	-2.3	-2.3	-2.2	-1.1	-2.7	-3.0	2.0	1.1	-0.9	-2.3
Alcohol intake frequency.	0.0	0.1	0.3	0.0	0.3	-0.1	-0.1	-0.6	-0.5	-0.2	0.2	0.2	0.2	-0.2	-0.2
Comparative height size at age 10	0.8	4.3	12.2	0.5	0.7	2.4	2.1	2.4	1.6	2.7	3.5	-0.3	-2.0	1.6	2.4
Number of full sisters	0.2	0.3	0.9	0.9	0.4	0.2	-0.1	0.1	-0.7	0.6	-0.1	0.5	0.4	-0.8	-0.6
Suffer from ‘nerves’	1.0	1.5	4.9	0.1	-0.4	-1.4	-1.1	-1.4	-1.1	-1.7	-0.3	-0.1	2.2	-1.4	-1.4
Overall health rating	0.5	1.0	6.3	0.8	0.4	0.9	0.6	1.1	-0.3	1.3	0.7	2.5	-0.1	-0.2	0.3
Chest pain or discomfort	0.3	0.4	1.0	0.6	0.7	0.1	-0.2	0.2	-0.8	0.7	-1.0	0.9	-0.0	-0.5	-0.5
Had major operations	0.4	0.5	1.3	0.1	-0.4	-1.0	-0.8	-1.2	-0.7	-0.8	-0.1	-0.3	0.2	-0.4	-1.2
Age at last live birth	1.4	2.0	6.0	-2.2	-2.4	-1.1	-0.8	-1.3	1.6	-1.0	0.1	-1.9	0.3	1.4	-0.1
Family relationship satisfaction	1.1	1.4	3.1	-1.3	-1.8	-1.6	-1.4	-1.3	0.1	-1.2	-1.2	-1.3	-0.1	0.6	-1.0
Leg pain on walking	0.1	0.1	0.4	0.6	0.3	-0.0	0.4	-0.0	-0.6	-0.4	-0.2	0.2	-0.4	-0.2	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	1.4	1.3	1.0	1.1	1.2	-0.5	1.0	-0.6	0.1	-0.7	-0.1	0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	0.8	1.3	1.5	1.6	1.0	0.4	0.7	0.9	0.2	-0.8	0.5	1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.0	0.5	0.5	-0.4	-0.0	-0.1	-0.4	0.2	1.3	-0.1	1.4	-0.5	-0.4
Medication: Aspirin	1.5	2.0	6.9	-2.6	-1.9	-1.2	-1.1	-1.1	1.3	-1.1	-0.2	-1.9	-0.3	1.7	-0.3
Supplements: Vitamin C	1.1	1.3	4.0	-1.0	-0.7	0.2	0.8	-0.0	1.6	-0.1	0.2	-2.0	-1.5	1.6	1.3
Knee pain experienced in last month	0.6	1.0	2.8	1.4	1.7	0.1	0.1	0.2	-1.3	0.2	-1.1	1.0	1.0	-1.4	-0.5
Hypertension (Self-reported)	0.9	2.4	4.8	0.3	0.2	2.2	2.2	1.7	1.4	1.9	1.3	-0.3	-1.6	1.5	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.0	0.8	0.6	1.7	1.4	1.4	0.5	1.6	0.8	-0.9	1.0	0.5	1.3
Illnesses of father: Heart disease	1.1	1.5	7.5	-0.6	0.0	0.1	0.7	0.5	0.8	0.2	1.0	-2.4	-2.7	1.0	0.7
Illnesses of siblings: Diabetes	1.5	1.8	3.6	-0.7	-0.6	-1.7	-1.6	-1.9	-1.2	-1.8	-1.4	0.7	0.9	-0.9	-1.8
Smoking status: Previous	0.4	0.6	3.8	0.2	0.0	0.8	0.5	0.6	0.4	0.7	0.8	-0.7	-1.9	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.8	0.4	0.0	0.7	0.2	0.8	0.1	1.1	1.7	0.8	1.5	0.0	0.2
Whole body fat-free mass	0.3	1.7	4.5	1.7	1.8	0.2	-0.5	0.1	-1.9	0.5	0.0	2.1	1.6	-1.5	-1.1
Leg fat-free mass (right)	0.1	0.8	2.4	0.9	0.9	0.8	0.2	0.6	-0.7	1.0	1.0	1.2	1.5	-0.5	-0.1
Arm fat percentage (left)	0.9	3.8	6.8	2.2	2.2	2.6	2.3	2.3	-0.4	2.6	2.2	1.8	-1.0	0.2	1.6
Average weekly red wine intake	0.8	1.2	3.0	0.8	0.6	1.5	1.4	1.5	0.8	1.3	0.5	-1.7	-0.2	0.5	1.3
Handedness (chirality/laterality): Left-handed	1.9	2.2	5.4	-1.0	-1.0	-2.0	-1.9	-2.1	-0.7	-2.3	-1.6	-0.7	0.6	-1.1	-1.6
Mood swings	3.3	6.0	12.6	0.4	0.6	-2.8	-2.7	-2.7	-2.5	-2.8	-1.6	1.1	3.6	-2.9	-3.2
Loneliness, isolation	0.0	0.1	0.6	-0.0	-0.1	-0.1	-0.0	0.2	0.2	-0.0	-0.1	0.0	0.7	-0.1	0.0
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.5	-0.7	0.7	0.8	0.4	1.2	0.5	0.8	0.3	0.5	1.1	1.1
Ever had bowel cancer screening	0.7	0.8	3.2	-0.5	-0.6	0.6	0.8	0.4	1.1	0.7	0.3	-1.8	-0.6	1.2	1.1
Diabetes diagnosed by doctor	0.2	0.4	1.0	-0.3	0.2	0.5	0.7	0.4	0.6	0.2	0.8	-0.1	-1.0	0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.9	-1.3	-1.4	-0.5	-0.1	-0.3	1.4	-0.4	0.4	-1.4	-0.5	1.2	0.4
Friendships satisfaction	0.3	0.3	1.4	0.6	-0.1	0.5	0.4	0.8	0.0	0.7	-0.2	-1.2	-0.8	0.2	0.1
Qualifications: nursing, teaching	0.6	1.0	4.2	1.0	0.7	-0.3	-0.2	-0.1	-1.5	-0.4	-0.4	1.3	2.0	-1.2	-0.7
Commuting to job workplace: Walk	1.1	1.2	5.1	-0.0	-0.0	-1.2	-1.1	-1.1	-0.8	-0.8	-2.3	1.0	1.0	-0.9	-1.2
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.4	-0.1	0.8	1.0	0.6	1.3	0.6	1.1	-0.8	-1.2	1.4	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.0	-0.4	-1.0	0.6	0.8	0.8	1.3	0.6	1.6	-0.9	1.7	1.2	1.2
Medication for cholesterol	2.3	3.5	6.7	-0.9	-1.3	-2.6	-2.5	-2.5	-1.1	-2.4	-2.0	-0.3	1.5	-1.2	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	7.2	-0.2	-0.2	1.4	0.9	1.1	1.1	1.7	2.7	-0.5	-0.2	1.3	1.1
Back pain experienced in last month	2.8	4.1	9.7	3.1	2.8	2.6	2.5	2.9	-0.8	2.2	0.7	0.7	-0.9	-0.6	1.5
Mineral and other dietary supplements	1.0	1.3	4.0	0.1	-0.1	-0.8	-1.5	-0.5	-1.2	-0.5	0.4	1.6	2.0	-1.1	-1.6
Breast cancer (self-reported)	1.5	1.8	4.7	1.9	1.5	-0.3	-0.3	-0.4	-2.0	-0.2	-1.0	1.5	1.3	-2.2	-1.2
Asthma (self-reported)	1.1	2.1	5.3	-1.0	-1.4	1.1	1.4	1.0	2.1	1.1	1.9	-0.4	0.7	2.3	1.8
Osteoporosis (self-reported)	0.7	0.9	3.2	-1.3	-1.4	-0.7	-0.7	-0.9	0.6	-0.9	0.2	-1.8	0.1	0.7	-0.3
Osteoarthritis (self-reported)	1.7	2.2	5.1	1.3	1.3	-0.9	-1.1	-1.0	-2.3	-0.9	-1.7	1.7	0.6	-2.3	-1.8
Medication: Aspirin	1.3	1.7	6.1	-2.5	-1.7	-1.3	-1.2	-1.1	1.0	-1.2	-0.4	-1.6	-0.3	1.4	-0.5
Medication: Gliclazide	0.9	1.0	2.1	-1.2	-0.8	-1.1	-1.4	-1.2	-0.1	-1.4	-1.1	-0.1	-1.0	0.0	-1.2
Illnesses of father: None of the above (group 1)	2.7	3.4	7.5	0.3	0.0	-1.8	-1.6	-1.8	-1.8	-2.2	-2.7	2.4	1.8	-1.9	-1.9
Smoking status: Current	0.4	0.6	2.9	-0.3	-1.0	-0.2	-0.9	-0.0	0.0	0.4	1.2	1.7	0.3	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.1	1.6	1.7	0.4	1.1	0.9	-1.0	-0.2	-1.0	1.8	0.7	-0.7	0.4
Whole body water mass	0.3	1.7	4.5	1.7	1.8	0.3	-0.3	0.3	-1.8	0.7	0.2	2.1	1.5	-1.5	-1.0
Leg predicted mass (right)	0.1	0.7	2.4	0.8	0.8	0.8	0.1	0.6	-0.6	1.0	1.0	1.1	1.5	-0.4	-0.1
Arm fat mass (left)	0.7	3.1	6.0	2.4	2.4	2.1	1.5	1.8	-1.2	2.2	1.5	2.3	-0.5	-0.6	0.7
Number of self-reported non-cancer illnesses	1.3	2.3	4.4	-0.7	-0.8	1.8	1.4	1.4	1.8	1.7	1.8	-0.8	-0.2	2.1	2.0
Average weekly champagne plus white wine intake	0.3	0.5	1.4	-0.6	-0.8	-0.7	-0.9	-0.7	-0.1	-0.3	-1.2	-0.9	-0.3	0.1	-0.6
Miserableness	1.0	1.7	3.4	-0.2	-0.4	-1.9	-1.8	-1.5	-1.1	-1.2	-1.8	0.4	1.0	-1.2	-1.9
Guilty feelings	0.3	0.5	1.5	-0.1	0.0	-1.0	-1.2	-0.7	-0.8	-0.4	-1.0	-0.1	0.6	-0.6	-1.0
Wears glasses or contact lenses	0.4	0.5	1.0	0.7	0.5	1.0	0.9	1.0	0.2	1.0	-0.6	0.7	-0.0	0.4	0.8
Ever taken oral contraceptive pill	1.8	2.0	5.2	0.2	-0.1	-1.9	-1.9	-1.6	-1.5	-1.4	-0.8	0.9	0.7	-1.7	-2.3
Hearing aid user	3.1	3.5	7.5	-1.2	-0.7	1.4	2.1	1.2	2.7	0.7	1.8	-1.8	-1.8	2.7	2.7
Mother’s age at death	0.7	0.9	3.4	-1.3	-1.3	0.1	0.6	0.1	1.8	-0.5	0.5	-0.1	-0.4	1.3	1.2
Financial situation satisfaction	0.2	0.2	0.8	-0.1	-0.6	-0.8	-0.3	-0.6	0.1	-0.7	-0.9	-0.0	0.3	-0.3	-0.0
Tinnitus: Yes, now most or all of the time	2.1	2.4	6.5	1.1	1.0	-1.4	-1.2	-1.2	-1.9	-1.2	-0.5	2.5	0.7	-1.9	-2.3
Commuting to job workplace: Public transport	0.4	0.5	2.0	-0.0	-0.7	-0.4	-0.9	-0.1	-0.3	0.4	-1.4	-0.7	0.8	-0.4	-0.7
Eye problems/disorders: Glaucoma	0.3	0.4	2.3	0.4	0.4	-0.3	0.0	-0.5	-0.4	-0.4	0.4	0.7	1.5	-0.9	-0.3
Medication: Blood pressure	2.4	4.6	10.0	0.7	1.0	3.2	2.9	2.7	1.6	2.5	1.2	-0.5	-2.8	1.6	2.8
Pain type(s) experienced in last month: Hip pain	1.8	2.2	5.2	1.6	1.8	-0.6	-0.6	-0.4	-2.3	-0.7	-2.0	1.7	1.2	-1.8	-1.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	3.0	0.0	0.2	0.2	0.4	0.2	0.2	-0.3	-1.3	-0.2	-1.7	0.1	0.4
High cholesterol (Self-reported)	1.6	2.9	5.1	-0.1	-0.1	2.1	1.7	2.3	1.7	2.1	1.1	-0.8	-2.3	1.7	2.2
Medication: Bendroflumethiazide	0.3	0.5	2.0	-1.0	-0.4	0.1	-0.6	-0.3	0.6	-0.0	-1.4	-0.1	-1.1	0.5	-0.2
Medication: Paracetamol	0.2	0.3	0.8	0.3	0.2	0.7	0.8	0.7	0.3	0.5	0.9	-0.2	0.3	0.3	0.5
Medication: Lisinopril	0.7	0.9	2.1	0.5	0.4	1.3	1.0	1.4	0.4	1.3	1.1	-0.7	-0.8	0.3	1.0
Medication: Atorvastatin	1.0	1.3	2.6	1.2	1.4	1.6	1.4	1.4	-0.3	1.5	0.3	0.7	-1.1	0.2	1.1
Illnesses of father: High blood pressure	0.9	1.1	3.2	-0.0	0.1	1.3	0.9	0.9	1.0	1.8	1.4	-1.1	0.8	0.9	1.1
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	0.4	0.1	-0.1	0.0	-0.2	0.0	-0.0	0.2	-0.6	-0.6	0.1
Ever smoked	0.5	0.8	2.3	-0.5	-1.0	0.5	0.1	0.6	1.0	1.0	1.5	-0.6	-1.5	0.9	0.4
Basal metabolic rate	0.3	1.9	5.3	1.9	2.0	0.6	-0.1	0.5	-1.8	0.9	0.5	2.3	1.2	-1.4	-0.8
Leg fat percentage (left)	1.2	4.5	11.9	3.2	3.5	1.8	1.4	1.7	-2.2	1.9	0.8	3.3	-0.9	-1.5	0.3
Arm fat-free mass (left)	0.5	2.5	8.7	2.0	2.1	0.1	-0.6	-0.1	-2.3	0.6	-0.0	2.9	1.3	-1.9	-1.3
Number of operations (self-reported)	0.7	1.0	2.9	-0.6	-1.1	0.3	0.7	0.1	1.4	0.8	0.7	-0.6	-1.4	1.7	1.2
Average weekly beer plus cider intake	0.4	0.6	2.4	-0.9	-0.9	-0.7	-0.5	-0.8	0.3	-1.6	1.0	-0.4	0.4	0.3	-0.4
Irritability	0.3	0.4	2.3	0.6	0.3	0.0	0.3	0.0	-0.2	-0.0	1.0	1.5	1.1	-0.4	0.0
Risk taking	0.5	0.8	1.6	1.1	1.3	1.2	0.9	1.0	-0.6	1.2	0.7	0.8	0.4	0.1	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.4	-1.4	-0.8	-0.3	-0.8	-0.2	0.9	0.1	-2.1	-1.5	-0.6	0.7	0.0
Fractured/broken bones in last 5 years	0.6	0.8	1.8	1.2	1.1	-0.2	0.1	-0.4	-1.2	-0.8	-1.4	1.1	-0.5	-0.8	-0.6
Age started oral contraceptive pill	0.5	0.7	3.0	-0.6	-0.1	-0.8	-0.5	-1.2	0.1	-1.4	0.3	0.4	1.7	-0.6	-0.2
Diastolic blood pressure, automated reading	0.8	2.6	6.7	2.6	2.6	1.9	1.8	1.5	-1.3	1.3	-0.4	2.0	-0.8	-0.8	0.5
Ever depressed for a whole week	1.3	1.6	3.0	-1.4	-1.7	-1.6	-1.0	-1.5	0.1	-1.4	-1.4	-1.7	0.6	0.2	-0.8
Unable to work because of sickness or disability	0.5	0.7	2.9	0.7	0.4	-0.0	-0.7	-0.2	-1.1	0.1	-0.7	1.7	-0.3	-1.1	-0.9
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.2	-0.1	-1.2	-1.0	-1.0	-0.8	-1.3	-0.3	-0.3	0.4	-0.7	-1.0
Myopia	3.4	5.0	8.8	-0.0	-0.2	2.6	2.1	3.0	2.0	2.9	1.5	-2.7	-2.4	2.2	2.6
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.9	0.1	0.1	-1.7	-1.7	-1.2	-1.2	-1.5	-1.0	1.0	2.0	-1.5	-1.7
Cholesterol lowering medication	1.8	2.7	6.4	1.0	1.6	2.1	2.1	2.2	0.6	1.7	2.5	-0.1	-1.2	0.7	1.9
Medication: Omeprazole (e.g. Zanprol)	3.2	3.9	8.8	0.9	1.2	2.6	2.4	2.7	1.1	3.0	2.3	-1.0	-1.1	1.5	2.3
Pain experienced in last month	1.2	2.0	5.3	-1.6	-1.8	0.3	0.4	0.2	2.2	0.8	1.5	-1.9	-0.2	2.3	1.3
Supplements: Calcium	2.6	2.8	7.5	-1.3	-1.3	1.1	1.3	0.6	2.1	0.9	1.6	-2.7	-0.9	2.5	2.2
Basal cell carcinoma (self-reported)	0.4	0.5	3.3	0.3	0.3	0.2	0.7	0.3	0.5	0.1	1.8	-0.0	1.1	0.3	0.7
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.1	-0.7	-0.2	-1.6	-1.4	-1.4	-0.9	-1.8	-1.3	-0.2	0.9	-1.1	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.2	-0.6	-1.2	-0.5	-0.8	-0.5	-0.0	-0.3	-1.2	-1.5	1.5	0.3	-0.6
Heart disease (siblings)	1.0	1.2	2.5	1.1	1.2	1.6	1.3	1.3	0.1	1.4	0.9	-0.8	-1.5	0.5	0.9
Alcohol drinker status: Previous	0.2	0.2	0.6	0.2	0.0	0.7	0.4	0.3	0.3	0.0	0.3	-0.7	0.5	0.3	0.3
Pack years of smoking	3.2	4.6	9.2	-2.0	-2.0	-3.0	-3.0	-2.9	-0.6	-3.0	-2.2	0.0	0.2	-0.4	-2.5
Impedance of whole body	2.6	13.1	23.4	-1.2	-1.4	3.2	3.7	3.4	4.6	3.0	3.2	-3.6	-4.7	4.4	4.8
Leg fat mass (left)	1.0	3.8	11.2	2.9	3.0	1.7	1.1	1.5	-1.9	1.8	1.2	3.3	-0.2	-1.4	0.1
Arm predicted mass (left)	0.5	2.5	8.6	2.0	2.1	0.2	-0.5	0.1	-2.3	0.6	0.0	2.9	1.2	-1.9	-1.3