Hub : Genes

TM9SF3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0876 0.0372 7.5e-03 -0.003 NA 0.004 NA -0.004 7.0e-01 NA 1.6e-01 NA 9.9e-01
2 YFS Blood 0.0220 0.0091 3.4e-03 0.000 0.005 0.002 0.004 -0.001 3.5e-01 7.0e-03 5.0e-02 0.013 7.8e-01
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.1320 0.0680 4.8e-03 -0.005 0.025 -0.004 NA -0.005 9.6e-01 1.4e-02 6.6e-01 NA 9.3e-01
4 TCGA Prostate Adenocarcinoma 0.1549 0.0498 8.9e-12 0.142 0.121 0.140 NA 0.141 1.3e-14 1.2e-12 1.8e-14 NA 1.4e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 1.2 -1.0 -1.0 -0.1 -1.1
Bipolar Disorder or Schizophrenia 0.5 1.3 2.9 -1.7 1.0 -0.5 -1.0
Depressed Affect (Nagel 2018) 0.4 0.8 2.3 -1.5 0.7 -0.6 -0.4
Depression (Nagel 2018) 0.6 0.8 1.8 -1.3 0.8 -0.8 0.5
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.0 -1.0 -0.3 -1.4 0.7
Neuroticism (Nagel 2018) 0.7 1.7 2.5 -1.5 1.6 -1.4 0.1
Schizophrenia (2018) 0.8 1.7 4.5 -1.4 2.1 -0.6 -0.4
Schizophrenia vs Biploar Disorder 2.2 2.9 4.3 -2.1 1.5 -1.4 1.8
Worry (Nagel 2018) 0.9 1.8 3.0 -1.5 1.7 -1.1 -0.9
Alzheimer’s Disease (in mother) 1.1 1.3 3.0 -0.2 -0.5 1.7 -1.4
Alzheimer’s Disease (in father) 0.6 0.7 1.4 -1.2 -1.1 0.3 0.2
Alzheimer’s Disease (including proxy) 0.8 1.1 2.3 -1.5 -1.0 1.1 -0.2
Crohns Disease (2017) 0.8 1.7 2.5 -1.5 0.8 -1.6 1.1
Irritable Bowel Disease (IBD) 0.4 1.0 1.9 -1.2 0.3 -1.4 0.8
Ulcerative Colitis (UC) 0.2 0.4 0.7 -0.8 -0.3 -0.8 0.3
Major Depression (MDD) 0.4 0.5 1.4 0.2 -0.1 -1.2 -0.6
Reaction Time 0.9 1.7 3.8 -0.1 1.3 -1.2 1.9
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.9 -0.1 0.3 -0.8 1.7
Breast Cancer 0.3 0.7 1.4 1.2 -0.6 -0.0 -0.9
Ovarian Cancer 2.4 3.2 6.1 -1.8 2.5 -1.9 0.1
Prostate Cancer 0.2 0.3 0.3 -0.3 0.6 0.6 -0.5
Age at First Birth 2.0 2.9 11.3 0.1 -3.4 0.3 0.6
Bipolar Disorder (2011) 0.2 0.2 0.5 -0.5 -0.0 0.1 -0.7
Body Mass Index (BMI) (2010) 0.9 1.2 1.8 1.4 -0.1 1.3 -1.1
Coronary Artery Disease (CAD) 0.3 0.4 0.9 0.0 0.6 0.6 -0.9
Crohns Disease (2012) 1.2 1.9 3.4 -1.4 1.4 -0.6 1.9
Mean Putamen Volume 0.5 0.6 1.6 0.5 1.3 -0.0 -0.7
Fasting Glucose 1.0 1.2 2.3 -0.6 1.5 -0.5 -1.3
HbA1C 0.4 0.5 1.4 -0.2 -0.7 -0.2 1.2
HDL Cholesterol 0.3 0.6 1.1 0.2 0.7 -0.7 1.1
LDL Cholesterol 1.1 1.7 3.3 -0.9 -1.8 0.3 1.6
Lupus 0.8 1.2 4.4 -2.1 0.6 0.3 0.2
Neuroticism (2016) 0.0 0.1 0.2 -0.1 0.2 -0.4 0.2
Primary Biliary Cirrhosis 0.5 0.7 2.4 -1.6 0.3 -0.5 0.2
Rheumatoid Arthritis 1.8 2.5 3.8 1.7 2.0 -0.7 1.6
Schizophrenia (2014) 0.9 2.1 5.5 -1.4 2.3 -0.9 -0.2
Triglycerides 1.8 3.0 7.6 0.1 -1.6 2.8 -1.3
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.7 -1.7 0.7 0.8 -0.9
Ulcerative Colitis 0.2 0.3 1.0 -0.3 -0.1 -0.1 1.0
Blood Eosinophil Count 0.1 1.1 2.2 -1.0 0.2 1.1 -1.5
Blood Platelet Count 0.4 5.0 14.8 0.5 3.9 -1.9 -1.1
Blood Red Count 0.3 2.6 6.8 -0.4 2.6 0.6 1.8
Blood White Count 0.4 3.0 7.3 2.0 -0.0 1.0 -2.7
Heel T-Score 0.0 0.4 1.1 -0.2 1.0 -0.2 -0.5
BMI 0.1 0.5 1.0 -0.5 0.4 1.0 -0.8
Height 0.7 12.8 28.4 -4.7 -5.3 -0.2 0.5
Waist Hip Ratio (WHR) 0.3 1.4 2.2 -0.5 -1.4 1.5 -1.1
Systolic Blood Pressure 0.2 0.8 2.3 0.5 0.5 1.5 -0.6
Smoking Status 0.0 0.0 0.1 -0.3 0.0 -0.0 -0.0
Allergy or Eczema 0.4 1.0 2.1 0.1 0.9 -1.1 1.5
Cardiovascular Disease 0.4 1.5 2.3 0.6 1.1 1.5 -1.4
Hypothyroidism (self reported) 0.4 0.9 2.0 -0.6 -0.3 -1.4 -1.1
Respiratory disease 0.2 0.4 0.8 -0.5 0.9 -0.7 0.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.7 -0.2 0.8 1.6 -0.7
Lung FEV1/FVC ratio 2.0 10.3 15.2 2.6 -3.7 3.9 -2.4
Lung FVC 0.1 0.7 1.5 -0.5 1.2 -1.0 -0.5
Neuroticism 0.4 1.0 1.6 -1.3 1.2 -0.8 0.6
Chronotype (morning person) 3.1 7.1 14.1 2.3 -2.0 2.2 -3.8
Hair Pigment 0.0 0.7 1.2 -0.8 -0.3 -1.1 0.9
Tanning 0.0 0.4 0.6 -0.5 -0.6 0.6 0.8
Hand grip strength (left) 0.3 0.8 1.8 -0.2 -0.6 1.3 -1.0
Number of treatments/medications taken 0.9 1.7 4.4 0.9 2.1 1.1 -0.5
Average weekly spirits intake 1.5 1.9 5.7 1.0 0.2 0.9 -2.4
Sensitivity / hurt feelings 0.5 0.9 3.2 -0.5 0.3 -0.2 1.8
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 -0.7 0.7 -0.5 0.4
Hearing difficulty/problems: Yes 0.2 0.3 0.9 0.3 1.0 -0.3 -0.1
Relative age of first facial hair 0.3 0.6 1.4 0.5 -0.6 0.5 -1.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.2 0.4 0.5 1.1 1.0
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.9 -0.6 0.6 1.1 -1.4
Ever had hysterectomy (womb removed) 1.1 1.3 4.1 -2.0 0.3 -0.5 0.8
Systolic blood pressure, automated reading 0.5 1.6 3.2 1.5 0.8 1.8 -0.4
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.7 0.3 0.8 1.3 -0.4
Angina 0.3 0.4 1.2 -0.4 1.1 0.2 0.4
Medication for hormone replacement therapy 0.5 0.6 0.9 -0.8 1.0 -0.3 0.8
Vitamin and mineral supplements 1.3 1.7 5.5 -2.4 0.0 -1.2 -0.2
Supplements: Zinc 0.3 0.4 1.0 -0.1 0.0 -0.6 1.0
Medication: Co-codamol 1.2 1.4 3.4 -0.5 1.1 1.9 -0.8
Medication: Metformin 0.9 1.2 4.4 -0.1 -0.4 2.1 -0.6
Diabetes (father) 0.1 0.1 0.2 0.2 -0.4 0.2 -0.3
Diabetes (mother) 0.7 0.9 1.8 -0.0 -0.2 1.4 -1.3
Severe depression (siblings) 2.9 3.2 11.3 -3.4 0.9 0.3 -0.9
Pack years adult smoking proportion 0.1 0.2 0.4 -0.3 0.6 0.1 -0.6
Impedance of leg (right) 0.6 3.0 6.5 0.0 -2.5 -2.3 -0.7
Leg fat-free mass (left) 0.4 2.3 4.6 -1.9 -1.0 2.2 0.0
Trunk fat percentage 0.3 1.3 3.6 -0.3 -0.6 1.1 -1.9
Hand grip strength (right) 0.6 1.5 2.8 0.3 -1.1 1.7 -1.4
Townsend deprivation index at recruitment 1.1 1.6 3.2 0.5 0.4 1.7 -1.8
Current tobacco smoking 2.0 3.2 4.3 1.9 1.1 2.1 -2.0
Average weekly fortified wine intake 0.1 0.1 0.2 0.2 -0.5 0.3 -0.0
Maternal smoking around birth 2.2 3.1 5.7 2.0 2.4 1.4 -0.9
Fed-up feelings 0.4 0.8 2.7 -1.6 0.1 0.2 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.0 -1.7 0.7 0.1 0.2
Relative age voice broke 0.2 0.3 0.9 -0.2 0.6 -1.0 -0.1
Taking other prescription medications 0.4 0.6 1.7 0.3 1.3 0.1 -0.9
Age when periods started (menarche) 2.0 4.7 12.5 -3.5 -2.3 1.0 -0.4
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 6.4 -2.5 0.9 -0.5 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 0.7 -0.0 -0.5 -0.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.0 -1.0 -0.3 0.3 -0.3
Qualifications: CSEs or equivalent 0.9 1.2 2.2 -1.2 -0.8 0.8 -1.5
Serious illness, injury or assault to yourself 0.8 1.0 2.2 -1.0 1.5 -0.8 -0.0
High blood pressure 0.6 1.6 2.4 -0.3 1.4 1.4 -1.6
Hayfever, allergic rhinitis or eczema 0.8 1.8 4.2 -0.1 0.6 -2.0 1.6
Multivitamins +/- minerals 2.6 3.3 7.2 2.3 -0.6 2.7 -0.4
Stomach or abdominal pain in last month 1.3 1.6 2.2 1.0 -1.4 1.1 -1.5
Supplements: Glucosamine 0.3 0.4 1.0 1.0 0.1 0.5 0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 -0.3 1.2 0.0 0.5
Medication: Atenolol 0.8 1.0 2.3 0.4 0.0 1.2 -1.5
Medication: Levothyroxine sodium 0.4 0.7 1.2 0.7 -1.1 -0.8 -0.6
Sitting height 0.4 3.1 5.2 -2.3 -2.0 -0.9 1.4
Chronic bronchitis/emphysema (father) 1.0 1.1 3.8 0.4 2.0 -0.7 -0.0
High blood pressure (mother) 2.2 3.1 4.6 2.1 -0.4 2.1 -1.8
Body mass index (BMI) 0.5 2.1 6.6 -0.0 0.5 2.6 -1.2
Impedance of leg (left) 0.6 2.9 5.4 0.1 -2.3 -2.2 -1.2
Leg predicted mass (left) 0.4 2.3 4.7 -1.9 -1.1 2.2 0.0
Trunk fat mass 0.4 1.5 2.3 -0.8 -1.1 1.4 -1.5
Waist circumference 0.7 2.6 7.3 -0.2 -0.6 2.7 -1.6
Number of incorrect matches in round 1.6 2.7 4.5 0.3 1.6 -2.1 1.9
Past tobacco smoking 0.3 0.5 1.6 1.3 -0.2 0.3 -0.4
Alcohol usually taken with meals 1.7 2.8 6.2 1.6 -0.5 -2.5 1.5
Nervous feelings 1.0 1.8 3.1 -0.2 1.8 -1.7 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.9 -1.7 0.6 -1.1 0.2
Hearing difficulty/problems with background noise 0.5 0.8 1.7 -0.7 0.0 -1.3 1.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.1 1.1 0.0 -0.3 1.0
Had menopause 1.5 1.8 5.8 1.2 2.4 0.0 -0.4
Had other major operations 0.5 0.6 1.6 -0.8 1.3 -0.3 -0.1
Forced vital capacity (FVC) 0.4 1.5 2.2 -1.5 -1.4 -1.4 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.1 0.3 -1.1 0.2 -0.7
Ever unenthusiastic/disinterested for a whole week 2.5 3.1 11.2 -3.4 -0.1 0.6 0.9
Qualifications: None of the above 0.6 1.4 2.3 1.3 1.3 0.1 -1.5
Financial difficulties in last 2 years 2.0 2.7 8.3 -0.3 2.9 -1.3 0.8
Mouth/teeth dental problems 0.3 0.5 1.1 -0.1 -0.8 -1.1 0.4
Heart attack 1.5 1.9 4.8 -2.2 1.3 -0.3 0.9
Allergy 0.9 2.0 5.7 -0.1 -0.7 2.4 -1.2
Pain all over the body in last month 1.3 1.4 4.3 -0.8 2.1 -0.4 0.7
Diabetes (self-reported) 0.5 0.7 1.7 -0.4 1.3 -0.6 0.8
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 1.6 1.3 0.5 -1.2 0.9
Medication: Ramipril 2.6 3.4 7.4 0.4 0.2 2.4 -2.7
Medication: Simvastatin 0.7 1.1 2.0 1.1 -0.4 1.4 -0.9
Fluid intelligence score 0.3 0.6 1.7 -0.5 -1.3 0.7 -0.0
Illnesses of siblings 0.9 1.3 2.3 -1.5 -0.8 -1.1 0.9
Neuroticism score 0.4 0.8 1.3 -1.2 1.1 -0.7 0.2
Weight 0.5 2.2 4.7 -1.4 -1.2 2.2 -0.8
Impedance of arm (right) 0.2 0.9 2.2 0.6 -0.1 -1.5 -0.9
Arm fat percentage (right) 0.4 1.5 2.9 0.1 1.1 1.7 -1.4
Trunk fat-free mass 0.6 3.7 6.2 -2.3 -2.5 1.7 0.7
Hip circumference 0.3 1.3 3.1 -0.1 -0.8 1.7 -1.2
Time employed in main current job 1.0 1.1 3.1 1.8 0.4 0.3 -1.1
Alcohol intake versus 10 years previously 0.6 0.9 1.8 1.3 1.0 0.7 -0.6
Father’s age at death 0.8 1.1 2.1 -0.2 -1.3 -0.8 -1.5
Worrier / anxious feelings 0.3 0.5 1.3 -0.4 -0.7 -1.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.3 -0.9 1.1 0.1 -1.1
Falls in the last year 1.2 1.6 6.1 0.3 2.5 -0.2 -0.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 -0.6 0.2 -0.6 0.1
Number of live births 0.6 0.8 1.4 -1.2 1.2 -0.3 0.7
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 4.2 -0.8 -2.1 -0.4 0.4
Pulse rate 1.0 1.7 3.4 1.8 0.7 1.6 -0.7
Happiness 0.9 1.1 2.7 -0.4 -0.2 1.6 -1.1
Noisy workplace 0.3 0.4 0.9 0.8 0.3 -0.9 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.9 1.4 -0.2 0.4 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.6 0.6 0.8 1.3 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.5 0.9 0.3 0.8 1.0 0.4
Asthma 0.1 0.3 0.4 0.5 0.6 -0.3 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 -0.8 -0.6 -0.7 -0.1
Medication: Cholesterol lowering 0.7 1.0 2.1 -1.5 0.2 -0.8 1.1
Depression (self-reported) 0.9 1.1 2.8 -1.7 0.8 0.2 -0.9
Medication: Lansoprazole 0.8 0.9 1.9 -1.4 1.2 -0.5 -0.2
Prospective memory result 0.8 0.9 3.3 0.7 -1.8 0.0 -0.0
Lung cancer (father) 0.1 0.1 0.2 -0.4 0.3 0.4 0.1
Illnesses of mother 0.9 1.1 2.9 0.5 -0.1 -1.1 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 5.1 -0.2 -2.3 0.7 0.1
Pulse wave Arterial Stiffness index 0.4 0.5 1.3 1.2 -0.3 0.2 -0.7
Impedance of arm (left) 0.3 1.4 3.3 0.5 -0.7 -1.8 -1.2
Arm fat mass (right) 0.3 1.3 3.7 -0.8 -0.1 1.9 -1.0
Trunk predicted mass 0.7 3.8 6.9 -2.3 -2.6 1.7 0.6
Standing height 0.8 7.7 19.1 -3.3 -4.4 -0.5 0.8
Length of working week for main job 1.1 1.2 3.5 1.0 1.9 -0.0 -0.6
Exposure to tobacco smoke at home 0.7 0.8 1.6 0.3 -0.3 1.2 -1.3
Breastfed as a baby 0.9 1.1 3.5 0.5 1.9 -0.4 0.6
Tense / ‘highly strung’ 0.6 1.1 2.0 -1.3 1.4 -0.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.0 -1.6 1.7 -0.7 0.4
Hair/balding pattern: Pattern 4 1.4 3.3 5.3 -2.2 2.3 -1.2 1.4
Birth weight of first child 0.6 1.1 2.1 -1.4 0.2 -1.4 0.2
Peak expiratory flow (PEF) 0.4 0.9 3.2 0.3 -1.8 0.1 0.3
Pulse wave reflection index 0.9 1.1 2.6 -1.1 -0.1 -1.6 0.9
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.3 -0.3 1.5 -0.8 0.8
Loud music exposure frequency 0.9 1.0 1.6 0.6 1.3 0.6 -1.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.0 -0.6 -1.0 0.4 1.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 -0.4 0.3 1.1 -0.1
Blood clot in the leg (DVT) 1.4 1.8 2.6 -0.9 1.2 -1.5 1.6
Medication: Paracetamol 0.4 0.7 1.6 -0.7 0.2 1.3 -0.8
Headache pain in last month 1.0 1.7 3.6 -0.4 -1.7 0.5 -1.9
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 4.0 2.0 -0.4 1.0 -1.8
Glaucoma (self-reported) 0.6 0.7 2.4 0.1 0.2 -1.5 0.6
Gout (self-reported) 0.9 1.2 2.7 -1.6 -0.5 -0.6 1.2
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 3.0 0.8 0.7 -0.4 -1.7
Medication: Amlodipine 0.2 0.2 0.8 -0.0 -0.5 -0.1 -0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.7 -1.3 0.8 0.9 0.0
Birth weight 0.6 1.3 2.5 -0.1 1.6 -0.3 1.6
Chronic bronchitis/emphysema (mother) 1.5 1.8 2.9 -1.6 -0.1 -1.7 1.3
High blood pressure (siblings) 0.6 0.8 2.0 1.4 0.3 0.7 -0.8
Forced vital capacity (FVC), Best measure 0.3 1.1 3.4 -0.8 -1.9 -0.6 0.0
Body fat percentage 0.3 1.1 3.2 -0.3 -0.1 1.1 -1.8
Leg fat percentage (right) 0.4 1.3 2.9 0.0 -0.7 1.4 -1.7
Arm fat-free mass (right) 0.7 3.6 6.2 -2.5 -2.3 1.5 0.6
Exposure to tobacco smoke outside home 0.8 1.1 3.0 0.3 1.7 0.8 -0.9
Comparative body size at age 10 0.3 0.7 1.6 0.0 0.4 -1.1 1.3
Number of full brothers 0.3 0.3 0.6 0.4 0.5 0.7 -0.6
Worry too long after embarrassment 1.4 2.3 3.8 0.7 1.6 -1.5 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.0 -0.9 1.7 -0.7 0.8
Wheeze or whistling in the chest in last year 0.4 0.7 2.4 -0.4 1.6 0.2 0.3
Number of children fathered 0.3 0.4 1.0 -1.0 0.0 0.3 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 1.7 1.3 -0.5 0.0 -1.0
Age at first live birth 4.4 7.8 10.9 -2.3 -2.2 -3.3 3.2
Pulse wave peak to peak time 0.4 0.5 1.3 -1.1 0.0 -0.2 0.8
Health satisfaction 6.3 8.2 16.4 1.3 -0.4 3.8 -4.1
Shortness of breath walking on level ground 2.6 3.1 5.7 1.1 -0.1 2.4 -2.4
Qualifications: College or University degree 0.2 0.7 1.6 1.1 -0.3 -0.3 1.3
Eye problems/disorders: None of the above 0.4 0.4 0.7 -0.6 -0.8 -0.8 0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 -0.3 0.1 -0.4 -0.6
Emphysema/chronic bronchitis 0.3 0.4 0.7 -0.6 0.9 0.2 -0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.5 0.7 -0.1 -0.7 0.5
Neck or shoulder pain in last month 0.6 0.8 1.6 -1.3 0.1 1.2 -0.2
Medication: Blood pressure 0.6 1.1 3.1 -1.8 0.8 0.2 0.7
Angina (self-reported) 0.2 0.2 0.8 -0.4 0.9 0.1 0.2
Migraine (self-reported) 0.3 0.4 1.0 0.4 0.7 -1.0 0.1
Medication: Ibuprofen 0.1 0.2 0.3 -0.5 -0.6 0.0 -0.4
Medication: Allopurinol 0.7 0.9 2.2 -0.8 -1.5 0.7 0.5
Medication: Omeprazole 1.4 1.7 2.6 1.6 -1.2 0.8 -1.4
Medication: Seretide 50 evohaler 1.2 1.4 2.6 -1.6 0.9 0.0 1.4
Mean time to correctly identify matches 1.3 2.4 3.8 -0.1 1.9 -1.5 1.9
Heart disease (mother) 1.1 1.4 1.9 -0.2 1.4 1.4 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.9 0.6 -0.1 -0.9 0.0
Whole body fat mass 0.3 1.2 2.4 -0.7 -0.6 1.6 -1.3
Leg fat mass (right) 0.4 1.7 3.3 -0.7 -1.0 1.8 -1.4
Arm predicted mass (right) 0.6 3.0 5.1 -2.1 -2.3 1.5 0.3
Pulse rate, automated reading 1.0 3.3 5.4 1.5 0.5 2.3 -2.3
Alcohol intake frequency. 0.9 2.0 3.3 1.8 1.8 0.6 -1.0
Comparative height size at age 10 0.5 2.6 3.2 -1.7 -1.2 -1.6 1.8
Number of full sisters 0.1 0.2 0.4 -0.4 0.2 0.2 -0.7
Suffer from ‘nerves’ 0.8 1.2 3.4 -0.4 1.9 0.3 -1.1
Overall health rating 0.8 1.8 4.6 0.1 0.2 2.1 -1.6
Chest pain or discomfort 0.4 0.6 1.7 1.3 0.8 -0.1 -0.2
Had major operations 1.2 1.4 5.0 -0.2 2.2 -0.6 0.1
Age at last live birth 4.3 6.2 9.7 -2.6 -0.9 -2.7 3.1
Family relationship satisfaction 1.9 2.4 4.8 0.2 -0.2 2.2 -2.2
Leg pain on walking 1.1 1.4 3.5 -1.0 -0.5 1.9 -0.9
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.0 6.7 1.7 -0.5 2.6 -1.4
Commuting to job workplace: Car/motor vehicle 1.8 2.0 4.7 0.9 1.3 1.0 -2.2
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 9.0 1.1 -3.0 0.7 0.2
Medication: Aspirin 0.4 0.6 1.9 -0.1 1.4 -0.3 0.5
Supplements: Vitamin C 0.8 0.9 2.7 1.7 -0.4 0.8 -0.4
Knee pain experienced in last month 0.7 1.1 1.9 -1.4 0.8 1.0 0.8
Hypertension (Self-reported) 0.6 1.8 3.1 -0.1 1.3 1.8 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.6 2.0 0.2 1.4 0.2 -0.7
Illnesses of father: Heart disease 0.4 0.6 1.4 -1.2 -0.3 0.9 0.2
Illnesses of siblings: Diabetes 0.2 0.3 0.6 -0.5 0.5 -0.0 0.8
Smoking status: Previous 0.9 1.3 2.6 -1.6 -0.6 -1.1 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 4.0 -2.0 -1.4 -0.2 0.7
Whole body fat-free mass 0.5 3.1 5.1 -2.3 -1.9 1.9 0.4
Leg fat-free mass (right) 0.4 2.1 4.9 -1.8 -0.7 2.2 -0.2
Arm fat percentage (left) 0.4 1.8 3.4 0.2 0.7 1.8 -1.8
Average weekly red wine intake 0.2 0.4 1.1 1.1 -0.3 -0.4 -0.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.6 -1.2 0.9 -1.3 -0.3
Mood swings 0.2 0.4 1.2 -0.0 1.1 -0.0 -0.7
Loneliness, isolation 1.2 1.6 2.9 -1.7 0.3 -1.2 1.4
Long-standing illness, disability or infirmity 0.7 1.1 2.4 0.1 0.7 1.5 -1.2
Ever had bowel cancer screening 0.3 0.3 0.5 -0.6 0.2 -0.5 -0.7
Diabetes diagnosed by doctor 0.4 0.6 2.2 -0.2 1.5 0.5 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.3 0.5 -0.3 0.1
Friendships satisfaction 2.9 3.6 6.2 0.2 -2.5 2.5 -1.5
Qualifications: nursing, teaching 0.5 0.8 1.2 0.1 -0.9 -1.1 1.1
Commuting to job workplace: Walk 2.4 2.6 4.9 0.2 -2.0 -1.3 2.2
Eye problems/disorders: Cataract 0.6 0.7 2.2 0.4 1.5 0.5 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.9 0.1 0.3 -1.4 0.2
Medication for cholesterol 0.9 1.3 3.0 -1.0 -1.7 -1.1 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.9 -0.2 -0.9 0.7 0.4
Back pain experienced in last month 0.9 1.2 2.6 -1.3 -1.6 0.4 -0.8
Mineral and other dietary supplements 0.6 0.8 1.7 -1.1 0.0 -1.3 0.6
Breast cancer (self-reported) 0.1 0.1 0.2 0.5 0.2 -0.1 0.5
Asthma (self-reported) 0.2 0.3 0.5 0.7 0.6 -0.5 -0.6
Osteoporosis (self-reported) 0.5 0.6 2.5 0.1 1.6 -0.1 -0.1
Osteoarthritis (self-reported) 0.4 0.5 1.5 -0.2 -0.4 0.7 1.2
Medication: Aspirin 0.3 0.4 1.3 0.0 1.2 -0.2 0.4
Medication: Gliclazide 0.6 0.7 1.7 1.0 0.2 0.3 -1.3
Illnesses of father: None of the above (group 1) 0.6 0.7 1.6 0.9 -0.2 -1.3 0.5
Smoking status: Current 2.5 3.9 5.1 2.0 1.4 2.3 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.8 -0.7 -0.5 -0.8 1.3
Whole body water mass 0.6 3.2 5.2 -2.3 -1.9 1.9 0.4
Leg predicted mass (right) 0.4 2.2 5.1 -1.8 -0.8 2.3 -0.1
Arm fat mass (left) 0.4 1.7 4.8 -0.6 -0.4 2.2 -1.2
Number of self-reported non-cancer illnesses 1.0 1.7 2.6 1.4 1.6 0.8 -1.3
Average weekly champagne plus white wine intake 1.3 1.8 6.2 -0.6 -2.5 -0.6 0.6
Miserableness 0.3 0.6 1.4 -0.5 0.7 -1.2 0.3
Guilty feelings 0.2 0.3 0.6 -0.8 -0.1 -0.4 0.6
Wears glasses or contact lenses 0.8 0.9 3.0 0.6 1.7 0.2 -0.5
Ever taken oral contraceptive pill 0.6 0.7 1.3 1.0 -1.1 -0.6 -0.2
Hearing aid user 1.9 2.1 3.7 -1.2 1.3 -1.9 1.3
Mother’s age at death 4.0 5.0 11.4 -1.8 -3.4 -2.2 0.8
Financial situation satisfaction 0.4 0.5 1.0 1.0 0.6 0.7 -0.2
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.1 -0.4 0.2 0.5 -1.0
Commuting to job workplace: Public transport 1.7 2.0 4.5 -0.9 -0.3 -2.1 1.7
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 -0.2 0.0 -0.4 0.5
Medication: Blood pressure 0.4 0.8 1.6 0.6 0.6 1.3 -1.0
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.5 -0.2 1.1 1.2 -0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.7 1.1 -0.1 1.7 -0.5
High cholesterol (Self-reported) 0.3 0.5 1.8 0.2 -0.0 1.3 -0.3
Medication: Bendroflumethiazide 0.2 0.2 0.4 0.1 0.7 -0.5 0.5
Medication: Paracetamol 0.7 1.1 2.6 -0.7 -0.3 1.6 -1.0
Medication: Lisinopril 0.4 0.5 0.9 -0.6 0.9 0.8 -0.3
Medication: Atorvastatin 2.5 3.1 9.0 -3.0 0.2 -1.2 1.5
Illnesses of father: High blood pressure 0.4 0.5 0.9 1.0 -0.7 0.5 -0.5
Alcohol drinker status: Never 1.5 1.8 3.8 0.5 2.0 -1.5 1.0
Ever smoked 0.1 0.2 0.8 -0.2 -0.9 0.1 -0.0
Basal metabolic rate 0.6 3.1 4.6 -2.1 -1.8 2.1 0.1
Leg fat percentage (left) 0.4 1.6 4.3 0.2 -0.5 1.4 -2.1
Arm fat-free mass (left) 0.7 3.6 5.8 -2.4 -2.1 2.1 0.3
Number of operations (self-reported) 2.1 3.2 5.0 -2.0 1.6 -2.2 1.0
Average weekly beer plus cider intake 0.7 1.0 2.2 0.1 0.5 1.3 -1.5
Irritability 0.1 0.2 0.6 -0.4 0.8 -0.2 -0.4
Risk taking 1.2 1.8 5.4 -2.3 0.3 -0.3 1.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.0 0.8 -1.0 -0.8 -0.7
Fractured/broken bones in last 5 years 0.6 0.8 3.0 -1.7 0.3 -0.5 -0.0
Age started oral contraceptive pill 0.6 0.8 2.8 -0.0 -1.7 -0.5 0.3
Diastolic blood pressure, automated reading 0.6 1.8 4.9 0.7 -0.2 2.2 -1.3
Ever depressed for a whole week 1.5 1.8 2.4 -1.6 1.5 -1.1 1.2
Unable to work because of sickness or disability 2.4 3.1 3.4 1.7 1.8 1.8 -1.6
Commuting to job workplace: Cycle 0.1 0.2 0.5 -0.3 0.7 0.2 -0.2
Myopia 0.8 1.2 1.7 -1.1 -0.6 -1.2 1.3
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.1 0.2 -1.4 -1.5 1.2
Cholesterol lowering medication 1.3 2.0 5.7 1.4 0.2 2.4 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 2.7 1.7 -1.1 0.9 -1.2
Pain experienced in last month 0.8 1.4 4.5 2.1 0.8 -0.1 -0.6
Supplements: Calcium 0.6 0.6 1.2 -0.9 0.7 0.2 1.1
Basal cell carcinoma (self-reported) 1.3 1.6 4.0 -1.2 2.0 0.7 -0.6
Heart attack/myocardial infarction (self-reported) 1.1 1.5 3.9 -2.0 1.2 -0.1 0.7
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 2.9 -1.1 1.4 -1.5 1.7
Heart disease (siblings) 0.7 0.8 2.2 0.5 -0.2 0.9 -1.5
Alcohol drinker status: Previous 0.1 0.1 0.4 -0.1 0.4 -0.6 -0.1
Pack years of smoking 0.2 0.2 0.7 -0.4 0.8 0.3 -0.2
Impedance of whole body 0.5 2.6 5.1 0.4 -1.9 -2.3 -1.3
Leg fat mass (left) 0.4 1.7 3.3 -0.5 -0.8 1.8 -1.7
Arm predicted mass (left) 0.7 3.5 5.7 -2.4 -1.9 2.0 0.8