Hub : Genes

TM9SF3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0876	0.0372	7.5e-03	-0.003	NA	0.004	NA	-0.004	7.0e-01	NA	1.6e-01	NA	9.9e-01
2	YFS	Blood	0.0220	0.0091	3.4e-03	0.000	0.005	0.002	0.004	-0.001	3.5e-01	7.0e-03	5.0e-02	0.013	7.8e-01
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1320	0.0680	4.8e-03	-0.005	0.025	-0.004	NA	-0.005	9.6e-01	1.4e-02	6.6e-01	NA	9.3e-01
4	TCGA	Prostate Adenocarcinoma	0.1549	0.0498	8.9e-12	0.142	0.121	0.140	NA	0.141	1.3e-14	1.2e-12	1.8e-14	NA	1.4e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.2	-1.0	-1.0	-0.1	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.3	2.9	-1.7	1.0	-0.5	-1.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.3	-1.5	0.7	-0.6	-0.4
Depression (Nagel 2018)	0.6	0.8	1.8	-1.3	0.8	-0.8	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	-1.0	-0.3	-1.4	0.7
Neuroticism (Nagel 2018)	0.7	1.7	2.5	-1.5	1.6	-1.4	0.1
Schizophrenia (2018)	0.8	1.7	4.5	-1.4	2.1	-0.6	-0.4
Schizophrenia vs Biploar Disorder	2.2	2.9	4.3	-2.1	1.5	-1.4	1.8
Worry (Nagel 2018)	0.9	1.8	3.0	-1.5	1.7	-1.1	-0.9
Alzheimer’s Disease (in mother)	1.1	1.3	3.0	-0.2	-0.5	1.7	-1.4
Alzheimer’s Disease (in father)	0.6	0.7	1.4	-1.2	-1.1	0.3	0.2
Alzheimer’s Disease (including proxy)	0.8	1.1	2.3	-1.5	-1.0	1.1	-0.2
Crohns Disease (2017)	0.8	1.7	2.5	-1.5	0.8	-1.6	1.1
Irritable Bowel Disease (IBD)	0.4	1.0	1.9	-1.2	0.3	-1.4	0.8
Ulcerative Colitis (UC)	0.2	0.4	0.7	-0.8	-0.3	-0.8	0.3
Major Depression (MDD)	0.4	0.5	1.4	0.2	-0.1	-1.2	-0.6
Reaction Time	0.9	1.7	3.8	-0.1	1.3	-1.2	1.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	-0.1	0.3	-0.8	1.7
Breast Cancer	0.3	0.7	1.4	1.2	-0.6	-0.0	-0.9
Ovarian Cancer	2.4	3.2	6.1	-1.8	2.5	-1.9	0.1
Prostate Cancer	0.2	0.3	0.3	-0.3	0.6	0.6	-0.5
Age at First Birth	2.0	2.9	11.3	0.1	-3.4	0.3	0.6
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.5	-0.0	0.1	-0.7
Body Mass Index (BMI) (2010)	0.9	1.2	1.8	1.4	-0.1	1.3	-1.1
Coronary Artery Disease (CAD)	0.3	0.4	0.9	0.0	0.6	0.6	-0.9
Crohns Disease (2012)	1.2	1.9	3.4	-1.4	1.4	-0.6	1.9
Mean Putamen Volume	0.5	0.6	1.6	0.5	1.3	-0.0	-0.7
Fasting Glucose	1.0	1.2	2.3	-0.6	1.5	-0.5	-1.3
HbA1C	0.4	0.5	1.4	-0.2	-0.7	-0.2	1.2
HDL Cholesterol	0.3	0.6	1.1	0.2	0.7	-0.7	1.1
LDL Cholesterol	1.1	1.7	3.3	-0.9	-1.8	0.3	1.6
Lupus	0.8	1.2	4.4	-2.1	0.6	0.3	0.2
Neuroticism (2016)	0.0	0.1	0.2	-0.1	0.2	-0.4	0.2
Primary Biliary Cirrhosis	0.5	0.7	2.4	-1.6	0.3	-0.5	0.2
Rheumatoid Arthritis	1.8	2.5	3.8	1.7	2.0	-0.7	1.6
Schizophrenia (2014)	0.9	2.1	5.5	-1.4	2.3	-0.9	-0.2
Triglycerides	1.8	3.0	7.6	0.1	-1.6	2.8	-1.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.7	-1.7	0.7	0.8	-0.9
Ulcerative Colitis	0.2	0.3	1.0	-0.3	-0.1	-0.1	1.0
Blood Eosinophil Count	0.1	1.1	2.2	-1.0	0.2	1.1	-1.5
Blood Platelet Count	0.4	5.0	14.8	0.5	3.9	-1.9	-1.1
Blood Red Count	0.3	2.6	6.8	-0.4	2.6	0.6	1.8
Blood White Count	0.4	3.0	7.3	2.0	-0.0	1.0	-2.7
Heel T-Score	0.0	0.4	1.1	-0.2	1.0	-0.2	-0.5
BMI	0.1	0.5	1.0	-0.5	0.4	1.0	-0.8
Height	0.7	12.8	28.4	-4.7	-5.3	-0.2	0.5
Waist Hip Ratio (WHR)	0.3	1.4	2.2	-0.5	-1.4	1.5	-1.1
Systolic Blood Pressure	0.2	0.8	2.3	0.5	0.5	1.5	-0.6
Smoking Status	0.0	0.0	0.1	-0.3	0.0	-0.0	-0.0
Allergy or Eczema	0.4	1.0	2.1	0.1	0.9	-1.1	1.5
Cardiovascular Disease	0.4	1.5	2.3	0.6	1.1	1.5	-1.4
Hypothyroidism (self reported)	0.4	0.9	2.0	-0.6	-0.3	-1.4	-1.1
Respiratory disease	0.2	0.4	0.8	-0.5	0.9	-0.7	0.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.7	-0.2	0.8	1.6	-0.7
Lung FEV1/FVC ratio	2.0	10.3	15.2	2.6	-3.7	3.9	-2.4
Lung FVC	0.1	0.7	1.5	-0.5	1.2	-1.0	-0.5
Neuroticism	0.4	1.0	1.6	-1.3	1.2	-0.8	0.6
Chronotype (morning person)	3.1	7.1	14.1	2.3	-2.0	2.2	-3.8
Hair Pigment	0.0	0.7	1.2	-0.8	-0.3	-1.1	0.9
Tanning	0.0	0.4	0.6	-0.5	-0.6	0.6	0.8
Hand grip strength (left)	0.3	0.8	1.8	-0.2	-0.6	1.3	-1.0
Number of treatments/medications taken	0.9	1.7	4.4	0.9	2.1	1.1	-0.5
Average weekly spirits intake	1.5	1.9	5.7	1.0	0.2	0.9	-2.4
Sensitivity / hurt feelings	0.5	0.9	3.2	-0.5	0.3	-0.2	1.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.7	0.7	-0.5	0.4
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.3	1.0	-0.3	-0.1
Relative age of first facial hair	0.3	0.6	1.4	0.5	-0.6	0.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	0.4	0.5	1.1	1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	-0.6	0.6	1.1	-1.4
Ever had hysterectomy (womb removed)	1.1	1.3	4.1	-2.0	0.3	-0.5	0.8
Systolic blood pressure, automated reading	0.5	1.6	3.2	1.5	0.8	1.8	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	0.3	0.8	1.3	-0.4
Angina	0.3	0.4	1.2	-0.4	1.1	0.2	0.4
Medication for hormone replacement therapy	0.5	0.6	0.9	-0.8	1.0	-0.3	0.8
Vitamin and mineral supplements	1.3	1.7	5.5	-2.4	0.0	-1.2	-0.2
Supplements: Zinc	0.3	0.4	1.0	-0.1	0.0	-0.6	1.0
Medication: Co-codamol	1.2	1.4	3.4	-0.5	1.1	1.9	-0.8
Medication: Metformin	0.9	1.2	4.4	-0.1	-0.4	2.1	-0.6
Diabetes (father)	0.1	0.1	0.2	0.2	-0.4	0.2	-0.3
Diabetes (mother)	0.7	0.9	1.8	-0.0	-0.2	1.4	-1.3
Severe depression (siblings)	2.9	3.2	11.3	-3.4	0.9	0.3	-0.9
Pack years adult smoking proportion	0.1	0.2	0.4	-0.3	0.6	0.1	-0.6
Impedance of leg (right)	0.6	3.0	6.5	0.0	-2.5	-2.3	-0.7
Leg fat-free mass (left)	0.4	2.3	4.6	-1.9	-1.0	2.2	0.0
Trunk fat percentage	0.3	1.3	3.6	-0.3	-0.6	1.1	-1.9
Hand grip strength (right)	0.6	1.5	2.8	0.3	-1.1	1.7	-1.4
Townsend deprivation index at recruitment	1.1	1.6	3.2	0.5	0.4	1.7	-1.8
Current tobacco smoking	2.0	3.2	4.3	1.9	1.1	2.1	-2.0
Average weekly fortified wine intake	0.1	0.1	0.2	0.2	-0.5	0.3	-0.0
Maternal smoking around birth	2.2	3.1	5.7	2.0	2.4	1.4	-0.9
Fed-up feelings	0.4	0.8	2.7	-1.6	0.1	0.2	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.0	-1.7	0.7	0.1	0.2
Relative age voice broke	0.2	0.3	0.9	-0.2	0.6	-1.0	-0.1
Taking other prescription medications	0.4	0.6	1.7	0.3	1.3	0.1	-0.9
Age when periods started (menarche)	2.0	4.7	12.5	-3.5	-2.3	1.0	-0.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	6.4	-2.5	0.9	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.7	-0.0	-0.5	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.0	-1.0	-0.3	0.3	-0.3
Qualifications: CSEs or equivalent	0.9	1.2	2.2	-1.2	-0.8	0.8	-1.5
Serious illness, injury or assault to yourself	0.8	1.0	2.2	-1.0	1.5	-0.8	-0.0
High blood pressure	0.6	1.6	2.4	-0.3	1.4	1.4	-1.6
Hayfever, allergic rhinitis or eczema	0.8	1.8	4.2	-0.1	0.6	-2.0	1.6
Multivitamins +/- minerals	2.6	3.3	7.2	2.3	-0.6	2.7	-0.4
Stomach or abdominal pain in last month	1.3	1.6	2.2	1.0	-1.4	1.1	-1.5
Supplements: Glucosamine	0.3	0.4	1.0	1.0	0.1	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.3	1.2	0.0	0.5
Medication: Atenolol	0.8	1.0	2.3	0.4	0.0	1.2	-1.5
Medication: Levothyroxine sodium	0.4	0.7	1.2	0.7	-1.1	-0.8	-0.6
Sitting height	0.4	3.1	5.2	-2.3	-2.0	-0.9	1.4
Chronic bronchitis/emphysema (father)	1.0	1.1	3.8	0.4	2.0	-0.7	-0.0
High blood pressure (mother)	2.2	3.1	4.6	2.1	-0.4	2.1	-1.8
Body mass index (BMI)	0.5	2.1	6.6	-0.0	0.5	2.6	-1.2
Impedance of leg (left)	0.6	2.9	5.4	0.1	-2.3	-2.2	-1.2
Leg predicted mass (left)	0.4	2.3	4.7	-1.9	-1.1	2.2	0.0
Trunk fat mass	0.4	1.5	2.3	-0.8	-1.1	1.4	-1.5
Waist circumference	0.7	2.6	7.3	-0.2	-0.6	2.7	-1.6
Number of incorrect matches in round	1.6	2.7	4.5	0.3	1.6	-2.1	1.9
Past tobacco smoking	0.3	0.5	1.6	1.3	-0.2	0.3	-0.4
Alcohol usually taken with meals	1.7	2.8	6.2	1.6	-0.5	-2.5	1.5
Nervous feelings	1.0	1.8	3.1	-0.2	1.8	-1.7	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.9	-1.7	0.6	-1.1	0.2
Hearing difficulty/problems with background noise	0.5	0.8	1.7	-0.7	0.0	-1.3	1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	1.1	0.0	-0.3	1.0
Had menopause	1.5	1.8	5.8	1.2	2.4	0.0	-0.4
Had other major operations	0.5	0.6	1.6	-0.8	1.3	-0.3	-0.1
Forced vital capacity (FVC)	0.4	1.5	2.2	-1.5	-1.4	-1.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.3	-1.1	0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	11.2	-3.4	-0.1	0.6	0.9
Qualifications: None of the above	0.6	1.4	2.3	1.3	1.3	0.1	-1.5
Financial difficulties in last 2 years	2.0	2.7	8.3	-0.3	2.9	-1.3	0.8
Mouth/teeth dental problems	0.3	0.5	1.1	-0.1	-0.8	-1.1	0.4
Heart attack	1.5	1.9	4.8	-2.2	1.3	-0.3	0.9
Allergy	0.9	2.0	5.7	-0.1	-0.7	2.4	-1.2
Pain all over the body in last month	1.3	1.4	4.3	-0.8	2.1	-0.4	0.7
Diabetes (self-reported)	0.5	0.7	1.7	-0.4	1.3	-0.6	0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.6	1.3	0.5	-1.2	0.9
Medication: Ramipril	2.6	3.4	7.4	0.4	0.2	2.4	-2.7
Medication: Simvastatin	0.7	1.1	2.0	1.1	-0.4	1.4	-0.9
Fluid intelligence score	0.3	0.6	1.7	-0.5	-1.3	0.7	-0.0
Illnesses of siblings	0.9	1.3	2.3	-1.5	-0.8	-1.1	0.9
Neuroticism score	0.4	0.8	1.3	-1.2	1.1	-0.7	0.2
Weight	0.5	2.2	4.7	-1.4	-1.2	2.2	-0.8
Impedance of arm (right)	0.2	0.9	2.2	0.6	-0.1	-1.5	-0.9
Arm fat percentage (right)	0.4	1.5	2.9	0.1	1.1	1.7	-1.4
Trunk fat-free mass	0.6	3.7	6.2	-2.3	-2.5	1.7	0.7
Hip circumference	0.3	1.3	3.1	-0.1	-0.8	1.7	-1.2
Time employed in main current job	1.0	1.1	3.1	1.8	0.4	0.3	-1.1
Alcohol intake versus 10 years previously	0.6	0.9	1.8	1.3	1.0	0.7	-0.6
Father’s age at death	0.8	1.1	2.1	-0.2	-1.3	-0.8	-1.5
Worrier / anxious feelings	0.3	0.5	1.3	-0.4	-0.7	-1.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-0.9	1.1	0.1	-1.1
Falls in the last year	1.2	1.6	6.1	0.3	2.5	-0.2	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.6	0.2	-0.6	0.1
Number of live births	0.6	0.8	1.4	-1.2	1.2	-0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.2	-0.8	-2.1	-0.4	0.4
Pulse rate	1.0	1.7	3.4	1.8	0.7	1.6	-0.7
Happiness	0.9	1.1	2.7	-0.4	-0.2	1.6	-1.1
Noisy workplace	0.3	0.4	0.9	0.8	0.3	-0.9	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.9	1.4	-0.2	0.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.6	0.6	0.8	1.3	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.3	0.8	1.0	0.4
Asthma	0.1	0.3	0.4	0.5	0.6	-0.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	-0.8	-0.6	-0.7	-0.1
Medication: Cholesterol lowering	0.7	1.0	2.1	-1.5	0.2	-0.8	1.1
Depression (self-reported)	0.9	1.1	2.8	-1.7	0.8	0.2	-0.9
Medication: Lansoprazole	0.8	0.9	1.9	-1.4	1.2	-0.5	-0.2
Prospective memory result	0.8	0.9	3.3	0.7	-1.8	0.0	-0.0
Lung cancer (father)	0.1	0.1	0.2	-0.4	0.3	0.4	0.1
Illnesses of mother	0.9	1.1	2.9	0.5	-0.1	-1.1	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.1	-0.2	-2.3	0.7	0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	1.2	-0.3	0.2	-0.7
Impedance of arm (left)	0.3	1.4	3.3	0.5	-0.7	-1.8	-1.2
Arm fat mass (right)	0.3	1.3	3.7	-0.8	-0.1	1.9	-1.0
Trunk predicted mass	0.7	3.8	6.9	-2.3	-2.6	1.7	0.6
Standing height	0.8	7.7	19.1	-3.3	-4.4	-0.5	0.8
Length of working week for main job	1.1	1.2	3.5	1.0	1.9	-0.0	-0.6
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.3	-0.3	1.2	-1.3
Breastfed as a baby	0.9	1.1	3.5	0.5	1.9	-0.4	0.6
Tense / ‘highly strung’	0.6	1.1	2.0	-1.3	1.4	-0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.0	-1.6	1.7	-0.7	0.4
Hair/balding pattern: Pattern 4	1.4	3.3	5.3	-2.2	2.3	-1.2	1.4
Birth weight of first child	0.6	1.1	2.1	-1.4	0.2	-1.4	0.2
Peak expiratory flow (PEF)	0.4	0.9	3.2	0.3	-1.8	0.1	0.3
Pulse wave reflection index	0.9	1.1	2.6	-1.1	-0.1	-1.6	0.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.3	-0.3	1.5	-0.8	0.8
Loud music exposure frequency	0.9	1.0	1.6	0.6	1.3	0.6	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	-0.6	-1.0	0.4	1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	-0.4	0.3	1.1	-0.1
Blood clot in the leg (DVT)	1.4	1.8	2.6	-0.9	1.2	-1.5	1.6
Medication: Paracetamol	0.4	0.7	1.6	-0.7	0.2	1.3	-0.8
Headache pain in last month	1.0	1.7	3.6	-0.4	-1.7	0.5	-1.9
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.0	2.0	-0.4	1.0	-1.8
Glaucoma (self-reported)	0.6	0.7	2.4	0.1	0.2	-1.5	0.6
Gout (self-reported)	0.9	1.2	2.7	-1.6	-0.5	-0.6	1.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.0	0.8	0.7	-0.4	-1.7
Medication: Amlodipine	0.2	0.2	0.8	-0.0	-0.5	-0.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.7	-1.3	0.8	0.9	0.0
Birth weight	0.6	1.3	2.5	-0.1	1.6	-0.3	1.6
Chronic bronchitis/emphysema (mother)	1.5	1.8	2.9	-1.6	-0.1	-1.7	1.3
High blood pressure (siblings)	0.6	0.8	2.0	1.4	0.3	0.7	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.1	3.4	-0.8	-1.9	-0.6	0.0
Body fat percentage	0.3	1.1	3.2	-0.3	-0.1	1.1	-1.8
Leg fat percentage (right)	0.4	1.3	2.9	0.0	-0.7	1.4	-1.7
Arm fat-free mass (right)	0.7	3.6	6.2	-2.5	-2.3	1.5	0.6
Exposure to tobacco smoke outside home	0.8	1.1	3.0	0.3	1.7	0.8	-0.9
Comparative body size at age 10	0.3	0.7	1.6	0.0	0.4	-1.1	1.3
Number of full brothers	0.3	0.3	0.6	0.4	0.5	0.7	-0.6
Worry too long after embarrassment	1.4	2.3	3.8	0.7	1.6	-1.5	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.0	-0.9	1.7	-0.7	0.8
Wheeze or whistling in the chest in last year	0.4	0.7	2.4	-0.4	1.6	0.2	0.3
Number of children fathered	0.3	0.4	1.0	-1.0	0.0	0.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	1.7	1.3	-0.5	0.0	-1.0
Age at first live birth	4.4	7.8	10.9	-2.3	-2.2	-3.3	3.2
Pulse wave peak to peak time	0.4	0.5	1.3	-1.1	0.0	-0.2	0.8
Health satisfaction	6.3	8.2	16.4	1.3	-0.4	3.8	-4.1
Shortness of breath walking on level ground	2.6	3.1	5.7	1.1	-0.1	2.4	-2.4
Qualifications: College or University degree	0.2	0.7	1.6	1.1	-0.3	-0.3	1.3
Eye problems/disorders: None of the above	0.4	0.4	0.7	-0.6	-0.8	-0.8	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.3	0.1	-0.4	-0.6
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.6	0.9	0.2	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.7	-0.1	-0.7	0.5
Neck or shoulder pain in last month	0.6	0.8	1.6	-1.3	0.1	1.2	-0.2
Medication: Blood pressure	0.6	1.1	3.1	-1.8	0.8	0.2	0.7
Angina (self-reported)	0.2	0.2	0.8	-0.4	0.9	0.1	0.2
Migraine (self-reported)	0.3	0.4	1.0	0.4	0.7	-1.0	0.1
Medication: Ibuprofen	0.1	0.2	0.3	-0.5	-0.6	0.0	-0.4
Medication: Allopurinol	0.7	0.9	2.2	-0.8	-1.5	0.7	0.5
Medication: Omeprazole	1.4	1.7	2.6	1.6	-1.2	0.8	-1.4
Medication: Seretide 50 evohaler	1.2	1.4	2.6	-1.6	0.9	0.0	1.4
Mean time to correctly identify matches	1.3	2.4	3.8	-0.1	1.9	-1.5	1.9
Heart disease (mother)	1.1	1.4	1.9	-0.2	1.4	1.4	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	0.6	-0.1	-0.9	0.0
Whole body fat mass	0.3	1.2	2.4	-0.7	-0.6	1.6	-1.3
Leg fat mass (right)	0.4	1.7	3.3	-0.7	-1.0	1.8	-1.4
Arm predicted mass (right)	0.6	3.0	5.1	-2.1	-2.3	1.5	0.3
Pulse rate, automated reading	1.0	3.3	5.4	1.5	0.5	2.3	-2.3
Alcohol intake frequency.	0.9	2.0	3.3	1.8	1.8	0.6	-1.0
Comparative height size at age 10	0.5	2.6	3.2	-1.7	-1.2	-1.6	1.8
Number of full sisters	0.1	0.2	0.4	-0.4	0.2	0.2	-0.7
Suffer from ‘nerves’	0.8	1.2	3.4	-0.4	1.9	0.3	-1.1
Overall health rating	0.8	1.8	4.6	0.1	0.2	2.1	-1.6
Chest pain or discomfort	0.4	0.6	1.7	1.3	0.8	-0.1	-0.2
Had major operations	1.2	1.4	5.0	-0.2	2.2	-0.6	0.1
Age at last live birth	4.3	6.2	9.7	-2.6	-0.9	-2.7	3.1
Family relationship satisfaction	1.9	2.4	4.8	0.2	-0.2	2.2	-2.2
Leg pain on walking	1.1	1.4	3.5	-1.0	-0.5	1.9	-0.9
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	6.7	1.7	-0.5	2.6	-1.4
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.7	0.9	1.3	1.0	-2.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	9.0	1.1	-3.0	0.7	0.2
Medication: Aspirin	0.4	0.6	1.9	-0.1	1.4	-0.3	0.5
Supplements: Vitamin C	0.8	0.9	2.7	1.7	-0.4	0.8	-0.4
Knee pain experienced in last month	0.7	1.1	1.9	-1.4	0.8	1.0	0.8
Hypertension (Self-reported)	0.6	1.8	3.1	-0.1	1.3	1.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	2.0	0.2	1.4	0.2	-0.7
Illnesses of father: Heart disease	0.4	0.6	1.4	-1.2	-0.3	0.9	0.2
Illnesses of siblings: Diabetes	0.2	0.3	0.6	-0.5	0.5	-0.0	0.8
Smoking status: Previous	0.9	1.3	2.6	-1.6	-0.6	-1.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.0	-2.0	-1.4	-0.2	0.7
Whole body fat-free mass	0.5	3.1	5.1	-2.3	-1.9	1.9	0.4
Leg fat-free mass (right)	0.4	2.1	4.9	-1.8	-0.7	2.2	-0.2
Arm fat percentage (left)	0.4	1.8	3.4	0.2	0.7	1.8	-1.8
Average weekly red wine intake	0.2	0.4	1.1	1.1	-0.3	-0.4	-0.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.6	-1.2	0.9	-1.3	-0.3
Mood swings	0.2	0.4	1.2	-0.0	1.1	-0.0	-0.7
Loneliness, isolation	1.2	1.6	2.9	-1.7	0.3	-1.2	1.4
Long-standing illness, disability or infirmity	0.7	1.1	2.4	0.1	0.7	1.5	-1.2
Ever had bowel cancer screening	0.3	0.3	0.5	-0.6	0.2	-0.5	-0.7
Diabetes diagnosed by doctor	0.4	0.6	2.2	-0.2	1.5	0.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.3	0.5	-0.3	0.1
Friendships satisfaction	2.9	3.6	6.2	0.2	-2.5	2.5	-1.5
Qualifications: nursing, teaching	0.5	0.8	1.2	0.1	-0.9	-1.1	1.1
Commuting to job workplace: Walk	2.4	2.6	4.9	0.2	-2.0	-1.3	2.2
Eye problems/disorders: Cataract	0.6	0.7	2.2	0.4	1.5	0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.9	0.1	0.3	-1.4	0.2
Medication for cholesterol	0.9	1.3	3.0	-1.0	-1.7	-1.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.2	-0.9	0.7	0.4
Back pain experienced in last month	0.9	1.2	2.6	-1.3	-1.6	0.4	-0.8
Mineral and other dietary supplements	0.6	0.8	1.7	-1.1	0.0	-1.3	0.6
Breast cancer (self-reported)	0.1	0.1	0.2	0.5	0.2	-0.1	0.5
Asthma (self-reported)	0.2	0.3	0.5	0.7	0.6	-0.5	-0.6
Osteoporosis (self-reported)	0.5	0.6	2.5	0.1	1.6	-0.1	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.5	-0.2	-0.4	0.7	1.2
Medication: Aspirin	0.3	0.4	1.3	0.0	1.2	-0.2	0.4
Medication: Gliclazide	0.6	0.7	1.7	1.0	0.2	0.3	-1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	0.9	-0.2	-1.3	0.5
Smoking status: Current	2.5	3.9	5.1	2.0	1.4	2.3	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.8	-0.7	-0.5	-0.8	1.3
Whole body water mass	0.6	3.2	5.2	-2.3	-1.9	1.9	0.4
Leg predicted mass (right)	0.4	2.2	5.1	-1.8	-0.8	2.3	-0.1
Arm fat mass (left)	0.4	1.7	4.8	-0.6	-0.4	2.2	-1.2
Number of self-reported non-cancer illnesses	1.0	1.7	2.6	1.4	1.6	0.8	-1.3
Average weekly champagne plus white wine intake	1.3	1.8	6.2	-0.6	-2.5	-0.6	0.6
Miserableness	0.3	0.6	1.4	-0.5	0.7	-1.2	0.3
Guilty feelings	0.2	0.3	0.6	-0.8	-0.1	-0.4	0.6
Wears glasses or contact lenses	0.8	0.9	3.0	0.6	1.7	0.2	-0.5
Ever taken oral contraceptive pill	0.6	0.7	1.3	1.0	-1.1	-0.6	-0.2
Hearing aid user	1.9	2.1	3.7	-1.2	1.3	-1.9	1.3
Mother’s age at death	4.0	5.0	11.4	-1.8	-3.4	-2.2	0.8
Financial situation satisfaction	0.4	0.5	1.0	1.0	0.6	0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.1	-0.4	0.2	0.5	-1.0
Commuting to job workplace: Public transport	1.7	2.0	4.5	-0.9	-0.3	-2.1	1.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.2	0.0	-0.4	0.5
Medication: Blood pressure	0.4	0.8	1.6	0.6	0.6	1.3	-1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.5	-0.2	1.1	1.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.7	1.1	-0.1	1.7	-0.5
High cholesterol (Self-reported)	0.3	0.5	1.8	0.2	-0.0	1.3	-0.3
Medication: Bendroflumethiazide	0.2	0.2	0.4	0.1	0.7	-0.5	0.5
Medication: Paracetamol	0.7	1.1	2.6	-0.7	-0.3	1.6	-1.0
Medication: Lisinopril	0.4	0.5	0.9	-0.6	0.9	0.8	-0.3
Medication: Atorvastatin	2.5	3.1	9.0	-3.0	0.2	-1.2	1.5
Illnesses of father: High blood pressure	0.4	0.5	0.9	1.0	-0.7	0.5	-0.5
Alcohol drinker status: Never	1.5	1.8	3.8	0.5	2.0	-1.5	1.0
Ever smoked	0.1	0.2	0.8	-0.2	-0.9	0.1	-0.0
Basal metabolic rate	0.6	3.1	4.6	-2.1	-1.8	2.1	0.1
Leg fat percentage (left)	0.4	1.6	4.3	0.2	-0.5	1.4	-2.1
Arm fat-free mass (left)	0.7	3.6	5.8	-2.4	-2.1	2.1	0.3
Number of operations (self-reported)	2.1	3.2	5.0	-2.0	1.6	-2.2	1.0
Average weekly beer plus cider intake	0.7	1.0	2.2	0.1	0.5	1.3	-1.5
Irritability	0.1	0.2	0.6	-0.4	0.8	-0.2	-0.4
Risk taking	1.2	1.8	5.4	-2.3	0.3	-0.3	1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	0.8	-1.0	-0.8	-0.7
Fractured/broken bones in last 5 years	0.6	0.8	3.0	-1.7	0.3	-0.5	-0.0
Age started oral contraceptive pill	0.6	0.8	2.8	-0.0	-1.7	-0.5	0.3
Diastolic blood pressure, automated reading	0.6	1.8	4.9	0.7	-0.2	2.2	-1.3
Ever depressed for a whole week	1.5	1.8	2.4	-1.6	1.5	-1.1	1.2
Unable to work because of sickness or disability	2.4	3.1	3.4	1.7	1.8	1.8	-1.6
Commuting to job workplace: Cycle	0.1	0.2	0.5	-0.3	0.7	0.2	-0.2
Myopia	0.8	1.2	1.7	-1.1	-0.6	-1.2	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.1	0.2	-1.4	-1.5	1.2
Cholesterol lowering medication	1.3	2.0	5.7	1.4	0.2	2.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.7	1.7	-1.1	0.9	-1.2
Pain experienced in last month	0.8	1.4	4.5	2.1	0.8	-0.1	-0.6
Supplements: Calcium	0.6	0.6	1.2	-0.9	0.7	0.2	1.1
Basal cell carcinoma (self-reported)	1.3	1.6	4.0	-1.2	2.0	0.7	-0.6
Heart attack/myocardial infarction (self-reported)	1.1	1.5	3.9	-2.0	1.2	-0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	2.9	-1.1	1.4	-1.5	1.7
Heart disease (siblings)	0.7	0.8	2.2	0.5	-0.2	0.9	-1.5
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.1	0.4	-0.6	-0.1
Pack years of smoking	0.2	0.2	0.7	-0.4	0.8	0.3	-0.2
Impedance of whole body	0.5	2.6	5.1	0.4	-1.9	-2.3	-1.3
Leg fat mass (left)	0.4	1.7	3.3	-0.5	-0.8	1.8	-1.7
Arm predicted mass (left)	0.7	3.5	5.7	-2.4	-1.9	2.0	0.8