Hub : Genes

TMA7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.243	0.1000	7.2e-04	0.190	NA	0.152	NA	0.163	1.3e-05	NA	1.0e-04	NA	5.8e-05
2	GTEx	Heart Left Ventricle	0.157	0.0604	3.2e-06	0.056	NA	0.085	NA	0.076	6.1e-04	NA	2.9e-05	NA	7.7e-05
3	GTEx	Muscle Skeletal	0.278	0.0509	0.0e+00	0.394	NA	0.389	NA	0.406	5.1e-41	NA	1.8e-40	NA	1.5e-42
4	ROSMAP	Brain Pre-frontal Cortex	0.148	0.0427	4.4e-16	0.152	0.135	0.147	0.14	0.154	4.3e-19	5.7e-17	1.9e-18	1.3e-17	2.8e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	0.8	0.6	-0.9	-0.6	0.8
Bipolar Disorder or Schizophrenia	1.0	2.4	3.2	1.5	-1.8	-1.4	1.5
Depressed Affect (Nagel 2018)	4.1	8.6	9.6	3.1	-2.6	-3.1	3.0
Depression (Nagel 2018)	2.0	3.0	3.3	1.8	-1.5	-1.8	1.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	-0.5	-1.0	0.3	-0.4
Neuroticism (Nagel 2018)	2.5	5.8	6.7	2.3	-2.4	-2.4	2.6
Schizophrenia (2018)	0.9	2.0	2.4	1.4	-1.5	-1.3	1.4
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.1	0.2	-0.1	0.2
Worry (Nagel 2018)	0.4	0.9	1.0	1.0	-1.0	-0.9	0.9
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.5	0.0	0.5	-0.2
Alzheimer’s Disease (in father)	1.4	1.6	1.6	-1.3	1.3	1.2	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.1	1.7	-1.3	0.7	1.2	-0.9
Crohns Disease (2017)	0.1	0.1	0.4	-0.0	-0.7	-0.1	0.1
Irritable Bowel Disease (IBD)	1.0	2.4	3.3	-1.7	0.8	1.6	-1.8
Ulcerative Colitis (UC)	4.0	7.5	9.5	-2.8	2.3	2.8	-3.1
Major Depression (MDD)	2.8	3.4	4.3	2.1	-1.3	-2.0	1.9
Reaction Time	1.0	1.8	2.6	1.2	-1.6	-1.2	1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.2	0.2	-1.5	-0.3	0.3
Breast Cancer	0.3	0.8	1.5	-0.9	0.1	0.9	-1.2
Ovarian Cancer	0.3	0.4	1.2	0.4	-1.1	-0.3	0.4
Prostate Cancer	0.7	1.0	1.7	0.7	-1.3	-0.7	1.2
Age at First Birth	0.2	0.2	0.3	-0.5	-0.4	0.5	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.2	-0.5	-0.4	0.4	-0.2
Body Mass Index (BMI) (2010)	0.8	1.1	1.6	1.3	-0.5	-1.2	1.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.5	0.3	-0.2	0.0
Crohns Disease (2012)	0.8	1.3	3.1	0.8	-1.8	-0.8	0.9
Mean Putamen Volume	4.0	4.5	5.3	-2.3	1.8	2.3	-2.1
Fasting Glucose	3.4	4.0	6.4	2.5	-0.8	-2.2	2.0
HbA1C	1.1	1.3	3.0	0.3	1.7	0.6	-1.3
HDL Cholesterol	0.1	0.2	0.3	-0.5	-0.4	0.6	-0.5
LDL Cholesterol	0.4	0.7	0.8	-0.9	0.7	0.9	-0.9
Lupus	0.2	0.3	0.5	-0.6	0.7	0.5	-0.4
Neuroticism (2016)	2.1	3.0	4.0	1.7	-1.4	-1.8	2.0
Primary Biliary Cirrhosis	2.1	3.0	3.5	-1.9	1.4	1.9	-1.7
Rheumatoid Arthritis	0.1	0.1	0.2	-0.3	0.1	0.3	-0.4
Schizophrenia (2014)	0.9	1.9	2.0	1.3	-1.4	-1.3	1.4
Triglycerides	2.7	4.5	6.3	-1.9	2.5	1.9	-2.0
Type 2 Diabetes (T2D) (2012)	2.3	2.6	3.6	1.8	-0.8	-1.9	1.7
Ulcerative Colitis	2.6	3.7	4.6	-2.0	1.5	2.0	-2.1
Blood Eosinophil Count	0.9	6.9	13.1	-2.2	3.6	2.1	-2.3
Blood Platelet Count	0.8	9.6	10.9	-3.0	3.3	3.0	-3.0
Blood Red Count	0.1	0.8	1.2	0.9	0.6	-1.1	0.9
Blood White Count	1.1	8.3	10.8	3.3	-1.1	-3.3	3.2
Heel T-Score	0.3	2.5	8.8	0.8	3.0	-0.8	0.1
BMI	1.1	6.4	8.9	3.0	-0.8	-3.0	2.7
Height	0.3	4.8	13.8	-1.3	3.7	1.1	-1.7
Waist Hip Ratio (WHR)	4.8	21.8	27.9	-4.4	5.3	4.4	-4.6
Systolic Blood Pressure	0.1	0.3	0.8	0.4	-0.9	-0.2	0.5
Smoking Status	0.2	0.4	1.3	0.1	-1.2	-0.2	0.6
Allergy or Eczema	0.2	0.5	1.5	0.3	-1.2	-0.3	0.4
Cardiovascular Disease	0.1	0.4	0.5	0.6	-0.7	-0.6	0.7
Hypothyroidism (self reported)	4.7	10.7	14.4	2.9	-3.8	-3.0	3.3
Respiratory disease	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.8	-0.1	0.9	0.1	-0.2
Lung FEV1/FVC ratio	2.6	13.3	13.9	-3.6	3.7	3.5	-3.7
Lung FVC	1.1	5.6	6.7	-2.4	1.9	2.5	-2.6
Neuroticism	2.5	6.0	6.7	2.6	-2.2	-2.6	2.4
Chronotype (morning person)	0.8	1.9	3.0	1.5	-0.3	-1.7	1.4
Hair Pigment	0.0	0.5	0.7	-0.9	0.1	0.8	-0.8
Tanning	0.1	1.0	1.5	-1.1	1.2	0.9	-0.6
Hand grip strength (left)	0.2	0.4	0.7	0.6	-0.4	-0.7	0.9
Number of treatments/medications taken	0.3	0.5	0.6	0.7	-0.5	-0.7	0.8
Average weekly spirits intake	0.1	0.1	0.3	-0.2	0.6	0.1	-0.1
Sensitivity / hurt feelings	0.3	0.5	0.9	-0.4	1.0	0.5	-0.7
Frequency of depressed mood in last 2 weeks	2.4	3.3	3.6	1.9	-1.6	-1.9	1.9
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.6	0.2	-0.5	0.2
Relative age of first facial hair	0.1	0.1	0.4	-0.0	-0.6	0.1	0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	0.3	-0.8	-0.4	0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.7	-0.7	0.8	0.7	-0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	-0.4	-0.2	0.1
Systolic blood pressure, automated reading	0.3	1.0	1.4	1.0	-1.2	-0.9	0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.7	0.7	-0.7	-0.8	0.6
Angina	0.1	0.1	0.3	0.0	0.6	-0.1	0.1
Medication for hormone replacement therapy	0.1	0.2	0.2	0.4	-0.1	-0.4	0.4
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	0.1	-0.4	0.1
Supplements: Zinc	0.3	0.3	1.2	0.1	-1.1	-0.1	0.2
Medication: Co-codamol	0.1	0.1	0.2	0.4	-0.0	-0.4	0.2
Medication: Metformin	0.4	0.5	1.3	-0.3	1.1	0.3	-0.8
Diabetes (father)	1.8	2.2	2.7	-1.4	1.3	1.6	-1.6
Diabetes (mother)	0.2	0.3	0.5	0.6	-0.2	-0.7	0.5
Severe depression (siblings)	0.2	0.2	0.3	-0.6	-0.2	0.6	-0.4
Pack years adult smoking proportion	5.1	7.9	9.9	2.6	-3.1	-2.6	2.9
Impedance of leg (right)	0.6	2.8	3.3	-1.8	1.5	1.7	-1.5
Leg fat-free mass (left)	0.7	3.9	5.6	2.4	-0.5	-2.4	2.0
Trunk fat percentage	0.4	1.5	1.9	1.4	0.8	-1.4	1.2
Hand grip strength (right)	0.1	0.3	0.6	0.5	-0.1	-0.7	0.8
Townsend deprivation index at recruitment	0.5	0.6	1.0	0.6	-0.8	-0.7	1.0
Current tobacco smoking	0.1	0.2	0.4	0.2	-0.7	-0.2	0.4
Average weekly fortified wine intake	0.4	0.5	0.6	0.7	-0.6	-0.8	0.7
Maternal smoking around birth	0.4	0.5	1.1	-0.5	1.1	0.6	-0.5
Fed-up feelings	3.6	6.6	7.8	2.8	-2.0	-2.7	2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.1	0.3	-0.0	0.1
Relative age voice broke	0.9	1.4	2.3	1.0	-1.5	-0.9	1.2
Taking other prescription medications	0.9	1.3	1.6	1.3	-0.8	-1.2	1.2
Age when periods started (menarche)	1.8	4.4	4.7	2.0	-2.2	-2.1	2.1
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	2.5	-1.5	1.5	1.5	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.7	-0.4	1.9	0.3	-0.3
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.3	1.4	-0.6	-1.5	1.5
Qualifications: CSEs or equivalent	0.5	0.7	0.9	0.9	-0.5	-0.9	0.9
Serious illness, injury or assault to yourself	0.8	0.9	1.5	0.8	-1.2	-0.9	0.8
High blood pressure	0.4	1.1	2.7	0.7	-1.6	-0.8	0.8
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.3	1.0	-2.1	-1.0	1.2
Multivitamins +/- minerals	0.4	0.5	0.7	-0.9	0.4	0.9	-0.5
Stomach or abdominal pain in last month	0.2	0.3	0.3	0.5	-0.5	-0.5	0.5
Supplements: Glucosamine	0.0	0.0	0.1	0.1	0.3	-0.0	-0.0
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	3.8	1.7	-2.0	-1.7	1.7
Medication: Atenolol	0.5	0.7	0.9	-0.9	0.6	0.9	-0.7
Medication: Levothyroxine sodium	1.2	2.0	3.8	1.1	-1.9	-1.2	1.4
Sitting height	0.6	4.1	6.1	2.4	0.5	-2.5	2.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.3	-0.2	-0.2	0.1
High blood pressure (mother)	0.3	0.4	0.6	-0.8	0.1	0.7	-0.7
Body mass index (BMI)	0.5	2.0	3.0	1.7	-0.1	-1.7	1.5
Impedance of leg (left)	0.7	3.6	4.0	-2.0	1.9	1.9	-1.8
Leg predicted mass (left)	0.7	3.5	5.2	2.2	-0.5	-2.3	1.9
Trunk fat mass	0.5	2.0	2.8	1.6	0.7	-1.7	1.4
Waist circumference	0.2	0.7	2.5	-0.0	1.6	0.0	-0.4
Number of incorrect matches in round	6.6	11.0	11.4	3.4	-3.4	-3.3	3.2
Past tobacco smoking	0.2	0.3	0.6	0.8	-0.1	-0.7	0.4
Alcohol usually taken with meals	0.4	0.6	1.0	-0.7	0.6	0.8	-1.0
Nervous feelings	0.0	0.0	0.1	0.0	0.3	0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	4.7	2.2	-2.1	-2.1	2.2
Hearing difficulty/problems with background noise	0.6	0.9	1.3	1.2	-0.4	-1.1	0.9
Hair/balding pattern: Pattern 2	1.1	1.3	1.5	-1.1	1.1	1.2	-1.2
Had menopause	0.3	0.4	0.5	-0.6	0.5	0.6	-0.7
Had other major operations	0.1	0.1	0.5	0.2	-0.7	-0.1	0.2
Forced vital capacity (FVC)	0.4	1.4	1.7	-1.1	1.3	1.0	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.5	-0.2	2.1	0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	1.7	1.1	-1.3	-1.1	1.2
Qualifications: None of the above	0.0	0.1	0.2	-0.3	0.4	0.3	-0.1
Financial difficulties in last 2 years	0.3	0.3	0.6	-0.6	0.8	0.5	-0.4
Mouth/teeth dental problems	0.6	0.9	1.2	0.8	-1.1	-0.9	1.0
Heart attack	0.4	0.5	0.7	0.8	-0.2	-0.8	0.8
Allergy	0.2	0.3	1.2	-0.2	1.1	0.2	-0.3
Pain all over the body in last month	1.9	2.0	3.1	1.3	-1.8	-1.2	1.4
Diabetes (self-reported)	1.4	2.2	4.2	-1.1	2.0	1.1	-1.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.0	-0.6	-0.1	0.3
Medication: Ramipril	0.0	0.0	0.1	0.1	-0.3	-0.1	0.2
Medication: Simvastatin	0.5	0.7	1.0	-1.0	0.6	0.9	-0.8
Fluid intelligence score	1.3	2.7	5.5	1.3	-2.3	-1.4	1.3
Illnesses of siblings	0.1	0.1	0.2	0.3	0.4	-0.3	0.3
Neuroticism score	1.3	2.8	3.6	1.9	-1.1	-1.8	1.7
Weight	0.5	2.5	3.9	1.9	0.4	-2.0	1.6
Impedance of arm (right)	0.5	2.6	3.0	-1.7	1.6	1.6	-1.4
Arm fat percentage (right)	0.5	1.9	2.7	1.6	-0.0	-1.6	1.5
Trunk fat-free mass	0.4	2.3	3.5	1.8	-0.5	-1.9	1.5
Hip circumference	0.7	2.8	4.0	1.9	-0.7	-2.0	1.7
Time employed in main current job	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.0
Alcohol intake versus 10 years previously	0.9	1.4	2.7	-1.0	1.6	1.0	-0.8
Father’s age at death	3.4	4.6	5.8	-2.4	1.4	2.2	-2.4
Worrier / anxious feelings	1.3	2.4	3.2	1.8	-0.8	-1.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.6	1.2	-1.9	-1.1	1.3
Falls in the last year	2.8	3.7	4.2	-1.9	1.8	2.0	-2.0
Hair/balding pattern: Pattern 3	0.5	0.7	1.0	-1.0	0.6	1.0	-0.7
Number of live births	0.6	0.9	3.3	-0.3	1.8	0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	1.9	6.3	7.0	-2.5	2.5	2.4	-2.6
Pulse rate	2.8	4.6	12.6	-1.3	3.5	1.3	-1.6
Happiness	0.8	0.9	1.9	0.7	-1.4	-0.7	0.8
Noisy workplace	0.1	0.1	0.2	0.3	-0.1	-0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.0	-0.1	-1.4	0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	4.7	1.0	-2.2	-0.8	0.9
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.1	0.5	0.2	-0.3
Asthma	0.1	0.1	0.2	-0.5	-0.1	0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	-0.2	-0.5	0.3
Medication: Cholesterol lowering	0.2	0.3	1.2	-0.2	1.1	0.2	-0.2
Depression (self-reported)	0.2	0.3	0.5	-0.6	-0.3	0.7	-0.4
Medication: Lansoprazole	0.3	0.3	0.5	0.6	0.2	-0.6	0.7
Prospective memory result	0.3	0.4	1.2	-0.3	1.1	0.3	-0.3
Lung cancer (father)	1.6	1.9	2.5	1.2	-1.6	-1.3	1.4
Illnesses of mother	0.9	1.2	1.3	1.1	-1.0	-1.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	6.2	-2.5	2.2	2.4	-2.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.8	0.0	0.9	0.1	-0.1
Impedance of arm (left)	0.7	3.2	3.7	-1.8	1.9	1.7	-1.6
Arm fat mass (right)	0.5	2.2	3.2	1.8	0.2	-1.8	1.6
Trunk predicted mass	0.4	2.5	3.8	1.9	-0.6	-1.9	1.6
Standing height	0.1	0.6	1.9	0.5	1.4	-0.6	0.2
Length of working week for main job	0.1	0.2	0.6	-0.1	0.8	0.0	-0.1
Exposure to tobacco smoke at home	1.2	1.3	1.7	1.3	-0.5	-1.3	1.3
Breastfed as a baby	0.4	0.5	0.7	-0.8	0.5	0.8	-0.8
Tense / ‘highly strung’	4.3	7.2	7.6	2.7	-2.8	-2.6	2.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.8	-0.9	-0.7	0.8
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	0.6	-0.0	-0.5	0.5
Birth weight of first child	3.8	6.8	7.1	-2.6	2.6	2.6	-2.7
Peak expiratory flow (PEF)	0.6	1.4	1.9	-1.4	0.6	1.2	-1.3
Pulse wave reflection index	0.0	0.0	0.1	0.1	-0.3	-0.1	-0.1
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.1	1.3	-1.4	-1.4	1.4
Loud music exposure frequency	0.7	0.8	1.0	-1.0	0.9	0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.4	-0.2	0.3	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.5	-0.7	0.1	0.7	-0.6
Blood clot in the leg (DVT)	0.9	1.1	1.4	-1.2	0.6	1.2	-1.2
Medication: Paracetamol	1.2	2.0	2.2	1.4	-1.5	-1.4	1.4
Headache pain in last month	0.6	1.1	1.4	-1.2	0.8	1.1	-1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.5	0.3	-1.2	-0.2	0.2
Glaucoma (self-reported)	0.0	0.1	0.2	-0.0	0.5	-0.0	-0.1
Gout (self-reported)	0.4	0.5	1.3	-0.6	1.1	0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	6.9	1.3	-2.6	-1.4	1.6
Medication: Amlodipine	0.6	0.9	1.1	-1.0	0.8	1.0	-0.9
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	-0.2	0.2	0.3	-0.2
Birth weight	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.1	-1.4	1.0	1.4	-1.3
High blood pressure (siblings)	0.2	0.3	0.5	-0.5	0.3	0.6	-0.7
Forced vital capacity (FVC), Best measure	0.6	2.2	2.6	-1.5	1.4	1.4	-1.6
Body fat percentage	0.4	1.6	2.2	1.4	0.5	-1.5	1.3
Leg fat percentage (right)	0.2	0.7	1.1	1.0	0.3	-1.1	0.9
Arm fat-free mass (right)	0.7	3.8	5.8	2.4	-0.5	-2.4	1.9
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.1	0.0	0.2	-0.0
Comparative body size at age 10	0.7	1.9	2.4	-1.5	1.0	1.5	-1.4
Number of full brothers	0.3	0.3	0.9	0.4	-0.9	-0.3	0.5
Worry too long after embarrassment	0.1	0.2	0.5	-0.1	0.7	0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.7	0.9	-1.6	-0.9	0.9
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.5	0.4	-0.4	0.4
Number of children fathered	0.0	0.0	0.1	-0.0	0.3	-0.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.5	1.2	-0.2	-1.1	0.9
Age at first live birth	0.1	0.2	0.7	0.0	-0.8	0.0	-0.3
Pulse wave peak to peak time	0.3	0.4	1.0	0.3	-1.0	-0.5	0.5
Health satisfaction	1.2	1.6	2.2	1.5	-0.6	-1.4	1.3
Shortness of breath walking on level ground	0.2	0.3	0.4	-0.5	0.3	0.6	-0.6
Qualifications: College or University degree	0.4	1.3	2.5	1.1	-1.6	-1.1	0.7
Eye problems/disorders: None of the above	0.3	0.3	1.1	0.0	-1.0	-0.1	0.4
Mouth/teeth dental problems: Loose teeth	5.4	6.4	6.9	-2.5	2.5	2.5	-2.6
Emphysema/chronic bronchitis	0.5	0.6	0.7	-0.7	0.7	0.8	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	-0.7	0.3	0.7	-0.6
Neck or shoulder pain in last month	0.0	0.0	0.1	0.2	-0.0	-0.3	0.1
Medication: Blood pressure	0.0	0.0	0.1	0.2	0.1	-0.2	0.2
Angina (self-reported)	0.1	0.1	0.3	0.1	0.5	-0.1	0.1
Migraine (self-reported)	6.0	7.4	8.1	-2.7	2.7	2.7	-2.8
Medication: Ibuprofen	0.4	0.4	0.5	0.6	-0.6	-0.7	0.7
Medication: Allopurinol	0.6	0.8	2.1	-0.6	1.4	0.6	-0.6
Medication: Omeprazole	1.3	1.5	1.9	-1.3	1.0	1.4	-1.3
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.7	-0.3	-0.6	0.8
Mean time to correctly identify matches	0.7	1.3	2.4	0.9	-1.6	-0.9	1.0
Heart disease (mother)	0.4	0.5	0.8	-0.7	0.3	0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	4.0	-1.6	2.0	1.6	-1.7
Whole body fat mass	0.5	2.2	3.3	1.8	0.5	-1.8	1.5
Leg fat mass (right)	0.5	1.8	2.7	1.6	0.4	-1.6	1.3
Arm predicted mass (right)	0.8	4.1	6.1	2.5	-0.5	-2.5	2.0
Pulse rate, automated reading	1.6	5.1	15.1	-1.1	3.9	1.2	-1.6
Alcohol intake frequency.	0.6	1.4	2.2	-1.0	1.5	1.0	-1.1
Comparative height size at age 10	0.0	0.1	0.2	0.2	0.5	-0.2	0.0
Number of full sisters	0.6	0.8	1.1	-1.1	0.5	1.1	-0.8
Suffer from ‘nerves’	0.1	0.1	0.4	0.2	-0.6	-0.0	0.1
Overall health rating	0.0	0.1	0.2	0.4	0.4	-0.2	0.2
Chest pain or discomfort	0.3	0.5	0.5	0.6	-0.7	-0.6	0.7
Had major operations	2.2	2.6	3.1	1.4	-1.8	-1.5	1.7
Age at last live birth	0.3	0.5	0.7	0.7	-0.8	-0.7	0.4
Family relationship satisfaction	7.4	9.1	9.2	3.0	-3.0	-3.0	3.0
Leg pain on walking	0.7	0.9	1.1	-1.0	0.7	1.0	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	-0.1	0.6	0.1	-0.4
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.2	-1.5	2.3	1.5	-1.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.3	0.6	0.3	-0.5
Medication: Aspirin	0.5	0.7	0.7	-0.9	0.8	0.8	-0.8
Supplements: Vitamin C	0.4	0.5	0.6	-0.7	0.5	0.8	-0.7
Knee pain experienced in last month	3.3	5.2	5.9	-2.3	2.0	2.4	-2.4
Hypertension (Self-reported)	0.2	0.6	1.7	0.4	-1.3	-0.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	4.2	-1.6	2.1	1.5	-1.4
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.4
Illnesses of siblings: Diabetes	1.3	1.7	2.6	1.1	-1.6	-1.2	1.1
Smoking status: Previous	0.7	1.1	1.6	-1.3	0.8	1.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.3	0.3	-0.3	0.3
Whole body fat-free mass	0.6	3.4	5.1	2.2	-0.5	-2.2	1.8
Leg fat-free mass (right)	0.6	3.1	4.7	2.2	-0.3	-2.2	1.8
Arm fat percentage (left)	0.4	1.8	2.6	1.6	0.3	-1.6	1.4
Average weekly red wine intake	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	1.0	-0.3	-0.9	0.8
Mood swings	1.8	3.3	3.8	1.9	-1.4	-1.9	1.9
Loneliness, isolation	1.4	1.9	2.5	1.3	-1.3	-1.3	1.6
Long-standing illness, disability or infirmity	0.3	0.5	0.7	-0.7	0.5	0.7	-0.8
Ever had bowel cancer screening	0.2	0.2	0.7	-0.1	-0.8	0.0	-0.1
Diabetes diagnosed by doctor	0.5	0.9	2.5	-0.4	1.6	0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.6	-0.7	0.8	0.7	-0.6
Friendships satisfaction	8.0	9.9	12.2	3.0	-3.5	-3.0	3.0
Qualifications: nursing, teaching	4.3	6.6	7.6	2.5	-2.8	-2.6	2.5
Commuting to job workplace: Walk	3.9	4.2	6.3	1.9	-2.5	-1.8	1.9
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	3.8	-1.7	1.9	1.7	-1.9
Medication for cholesterol	0.3	0.4	0.6	0.8	-0.4	-0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	2.9	1.7	-0.8	-1.6	1.4
Back pain experienced in last month	1.0	1.4	2.0	-1.1	1.4	1.1	-1.2
Mineral and other dietary supplements	0.5	0.6	0.8	0.8	-0.9	-0.8	0.7
Breast cancer (self-reported)	0.4	0.4	0.7	-0.5	0.9	0.5	-0.6
Asthma (self-reported)	0.1	0.1	0.3	-0.5	-0.0	0.5	-0.2
Osteoporosis (self-reported)	8.1	10.0	12.7	2.9	-3.6	-3.0	3.2
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.4	0.8	0.5	-0.7
Medication: Aspirin	0.4	0.6	0.7	-0.8	0.6	0.8	-0.8
Medication: Gliclazide	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	0.2	0.3	-0.2	0.3
Smoking status: Current	0.2	0.4	0.5	0.5	-0.7	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	2.9	-1.3	1.7	1.3	-1.6
Whole body water mass	0.6	3.6	5.3	2.3	-0.6	-2.3	1.9
Leg predicted mass (right)	0.6	3.3	4.9	2.2	-0.3	-2.2	1.8
Arm fat mass (left)	0.6	2.3	3.4	1.8	0.3	-1.9	1.6
Number of self-reported non-cancer illnesses	0.2	0.4	1.4	-0.0	-1.2	-0.0	0.2
Average weekly champagne plus white wine intake	0.7	0.9	1.2	1.1	-0.9	-1.0	0.8
Miserableness	4.6	7.9	9.1	3.0	-2.3	-3.0	3.0
Guilty feelings	0.1	0.1	0.2	-0.4	0.4	0.4	-0.3
Wears glasses or contact lenses	0.7	0.8	1.1	1.1	-0.5	-1.1	0.9
Ever taken oral contraceptive pill	1.3	1.5	1.8	1.1	-1.3	-1.2	1.2
Hearing aid user	0.4	0.5	0.7	-0.6	0.9	0.6	-0.7
Mother’s age at death	0.6	0.7	1.1	-0.8	0.6	0.9	-1.1
Financial situation satisfaction	2.1	2.5	3.1	1.7	-1.2	-1.7	1.7
Tinnitus: Yes, now most or all of the time	2.4	2.8	3.2	-1.6	1.8	1.6	-1.6
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.7	-0.8	-0.5	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	0.2	0.8	-0.2	0.0
Medication: Blood pressure	0.2	0.4	0.6	-0.7	-0.3	0.8	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	0.6	0.4	-0.6	0.4
Supplements: Fish oil (including cod liver oil)	1.3	1.8	2.2	-1.5	1.3	1.3	-1.2
High cholesterol (Self-reported)	0.8	1.5	1.8	-1.3	1.3	1.2	-1.1
Medication: Bendroflumethiazide	0.1	0.2	0.6	0.4	-0.8	-0.3	0.3
Medication: Paracetamol	3.3	5.1	6.1	2.1	-2.5	-2.1	2.3
Medication: Lisinopril	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.2
Medication: Atorvastatin	0.1	0.1	0.3	-0.2	0.5	0.2	-0.4
Illnesses of father: High blood pressure	0.7	0.8	1.2	-1.1	0.6	0.9	-1.0
Alcohol drinker status: Never	1.2	1.4	1.7	-1.0	1.2	1.1	-1.3
Ever smoked	0.1	0.2	0.7	0.1	-0.8	-0.2	0.5
Basal metabolic rate	0.6	3.4	5.1	2.2	-0.4	-2.3	1.9
Leg fat percentage (left)	0.2	0.8	1.2	1.0	0.4	-1.1	0.9
Arm fat-free mass (left)	1.1	5.7	7.9	2.8	-1.1	-2.8	2.5
Number of operations (self-reported)	1.4	2.0	3.0	1.3	-1.7	-1.3	1.3
Average weekly beer plus cider intake	0.4	0.6	0.9	0.9	0.2	-0.9	0.9
Irritability	4.5	7.7	7.8	2.8	-2.8	-2.8	2.8
Risk taking	0.6	0.9	1.0	-0.9	1.0	0.9	-0.8
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.5	-1.3	1.9	1.3	-1.3
Fractured/broken bones in last 5 years	0.6	0.7	2.0	0.5	-1.4	-0.5	0.6
Age started oral contraceptive pill	0.0	0.0	0.1	0.1	0.0	-0.0	-0.4
Diastolic blood pressure, automated reading	0.3	1.1	1.5	1.2	-0.8	-1.1	0.9
Ever depressed for a whole week	0.7	0.8	2.1	0.5	-1.4	-0.5	0.8
Unable to work because of sickness or disability	0.5	0.7	1.0	-0.9	-0.2	1.0	-0.9
Commuting to job workplace: Cycle	0.6	0.8	0.9	1.0	-0.9	-0.9	0.7
Myopia	2.5	3.7	4.6	1.8	-2.2	-1.9	1.8
Vascular/heart problems diagnosed by doctor	0.8	2.3	3.3	-1.3	1.8	1.4	-1.4
Cholesterol lowering medication	0.3	0.4	0.5	-0.7	0.5	0.6	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.7	-0.8	0.6	0.8	-0.7
Pain experienced in last month	0.3	0.6	0.9	0.7	-0.9	-0.7	0.7
Supplements: Calcium	0.0	0.1	0.2	-0.1	-0.5	0.1	-0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.3	-0.4	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.7	-0.2	-0.7	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.8	0.1	0.8	-0.7
Heart disease (siblings)	0.3	0.4	0.6	0.6	-0.6	-0.6	0.8
Alcohol drinker status: Previous	0.5	0.5	0.8	-0.7	0.3	0.9	-0.9
Pack years of smoking	3.5	5.1	7.2	2.0	-2.7	-2.0	2.3
Impedance of whole body	0.9	4.6	5.2	-2.2	2.3	2.1	-2.0
Leg fat mass (left)	0.5	2.0	3.1	1.7	0.4	-1.8	1.4
Arm predicted mass (left)	0.6	3.0	4.5	2.1	-0.5	-2.1	1.7