Hub : Genes

TMA7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.243 0.1000 7.2e-04 0.190 NA 0.152 NA 0.163 1.3e-05 NA 1.0e-04 NA 5.8e-05
2 GTEx Heart Left Ventricle 0.157 0.0604 3.2e-06 0.056 NA 0.085 NA 0.076 6.1e-04 NA 2.9e-05 NA 7.7e-05
3 GTEx Muscle Skeletal 0.278 0.0509 0.0e+00 0.394 NA 0.389 NA 0.406 5.1e-41 NA 1.8e-40 NA 1.5e-42
4 ROSMAP Brain Pre-frontal Cortex 0.148 0.0427 4.4e-16 0.152 0.135 0.147 0.14 0.154 4.3e-19 5.7e-17 1.9e-18 1.3e-17 2.8e-19

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.3 0.5 0.8 0.6 -0.9 -0.6 0.8
Bipolar Disorder or Schizophrenia 1.0 2.4 3.2 1.5 -1.8 -1.4 1.5
Depressed Affect (Nagel 2018) 4.1 8.6 9.6 3.1 -2.6 -3.1 3.0
Depression (Nagel 2018) 2.0 3.0 3.3 1.8 -1.5 -1.8 1.7
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.1 -0.5 -1.0 0.3 -0.4
Neuroticism (Nagel 2018) 2.5 5.8 6.7 2.3 -2.4 -2.4 2.6
Schizophrenia (2018) 0.9 2.0 2.4 1.4 -1.5 -1.3 1.4
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.1 0.2 -0.1 0.2
Worry (Nagel 2018) 0.4 0.9 1.0 1.0 -1.0 -0.9 0.9
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.5 0.0 0.5 -0.2
Alzheimer’s Disease (in father) 1.4 1.6 1.6 -1.3 1.3 1.2 -1.3
Alzheimer’s Disease (including proxy) 0.7 1.1 1.7 -1.3 0.7 1.2 -0.9
Crohns Disease (2017) 0.1 0.1 0.4 -0.0 -0.7 -0.1 0.1
Irritable Bowel Disease (IBD) 1.0 2.4 3.3 -1.7 0.8 1.6 -1.8
Ulcerative Colitis (UC) 4.0 7.5 9.5 -2.8 2.3 2.8 -3.1
Major Depression (MDD) 2.8 3.4 4.3 2.1 -1.3 -2.0 1.9
Reaction Time 1.0 1.8 2.6 1.2 -1.6 -1.2 1.3
Verbal and Numeric Reasoning (VNR) 0.3 0.6 2.2 0.2 -1.5 -0.3 0.3
Breast Cancer 0.3 0.8 1.5 -0.9 0.1 0.9 -1.2
Ovarian Cancer 0.3 0.4 1.2 0.4 -1.1 -0.3 0.4
Prostate Cancer 0.7 1.0 1.7 0.7 -1.3 -0.7 1.2
Age at First Birth 0.2 0.2 0.3 -0.5 -0.4 0.5 -0.4
Bipolar Disorder (2011) 0.2 0.2 0.2 -0.5 -0.4 0.4 -0.2
Body Mass Index (BMI) (2010) 0.8 1.1 1.6 1.3 -0.5 -1.2 1.1
Coronary Artery Disease (CAD) 0.1 0.1 0.2 0.5 0.3 -0.2 0.0
Crohns Disease (2012) 0.8 1.3 3.1 0.8 -1.8 -0.8 0.9
Mean Putamen Volume 4.0 4.5 5.3 -2.3 1.8 2.3 -2.1
Fasting Glucose 3.4 4.0 6.4 2.5 -0.8 -2.2 2.0
HbA1C 1.1 1.3 3.0 0.3 1.7 0.6 -1.3
HDL Cholesterol 0.1 0.2 0.3 -0.5 -0.4 0.6 -0.5
LDL Cholesterol 0.4 0.7 0.8 -0.9 0.7 0.9 -0.9
Lupus 0.2 0.3 0.5 -0.6 0.7 0.5 -0.4
Neuroticism (2016) 2.1 3.0 4.0 1.7 -1.4 -1.8 2.0
Primary Biliary Cirrhosis 2.1 3.0 3.5 -1.9 1.4 1.9 -1.7
Rheumatoid Arthritis 0.1 0.1 0.2 -0.3 0.1 0.3 -0.4
Schizophrenia (2014) 0.9 1.9 2.0 1.3 -1.4 -1.3 1.4
Triglycerides 2.7 4.5 6.3 -1.9 2.5 1.9 -2.0
Type 2 Diabetes (T2D) (2012) 2.3 2.6 3.6 1.8 -0.8 -1.9 1.7
Ulcerative Colitis 2.6 3.7 4.6 -2.0 1.5 2.0 -2.1
Blood Eosinophil Count 0.9 6.9 13.1 -2.2 3.6 2.1 -2.3
Blood Platelet Count 0.8 9.6 10.9 -3.0 3.3 3.0 -3.0
Blood Red Count 0.1 0.8 1.2 0.9 0.6 -1.1 0.9
Blood White Count 1.1 8.3 10.8 3.3 -1.1 -3.3 3.2
Heel T-Score 0.3 2.5 8.8 0.8 3.0 -0.8 0.1
BMI 1.1 6.4 8.9 3.0 -0.8 -3.0 2.7
Height 0.3 4.8 13.8 -1.3 3.7 1.1 -1.7
Waist Hip Ratio (WHR) 4.8 21.8 27.9 -4.4 5.3 4.4 -4.6
Systolic Blood Pressure 0.1 0.3 0.8 0.4 -0.9 -0.2 0.5
Smoking Status 0.2 0.4 1.3 0.1 -1.2 -0.2 0.6
Allergy or Eczema 0.2 0.5 1.5 0.3 -1.2 -0.3 0.4
Cardiovascular Disease 0.1 0.4 0.5 0.6 -0.7 -0.6 0.7
Hypothyroidism (self reported) 4.7 10.7 14.4 2.9 -3.8 -3.0 3.3
Respiratory disease 0.0 0.0 0.0 -0.2 -0.2 0.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.8 -0.1 0.9 0.1 -0.2
Lung FEV1/FVC ratio 2.6 13.3 13.9 -3.6 3.7 3.5 -3.7
Lung FVC 1.1 5.6 6.7 -2.4 1.9 2.5 -2.6
Neuroticism 2.5 6.0 6.7 2.6 -2.2 -2.6 2.4
Chronotype (morning person) 0.8 1.9 3.0 1.5 -0.3 -1.7 1.4
Hair Pigment 0.0 0.5 0.7 -0.9 0.1 0.8 -0.8
Tanning 0.1 1.0 1.5 -1.1 1.2 0.9 -0.6
Hand grip strength (left) 0.2 0.4 0.7 0.6 -0.4 -0.7 0.9
Number of treatments/medications taken 0.3 0.5 0.6 0.7 -0.5 -0.7 0.8
Average weekly spirits intake 0.1 0.1 0.3 -0.2 0.6 0.1 -0.1
Sensitivity / hurt feelings 0.3 0.5 0.9 -0.4 1.0 0.5 -0.7
Frequency of depressed mood in last 2 weeks 2.4 3.3 3.6 1.9 -1.6 -1.9 1.9
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.6 0.2 -0.5 0.2
Relative age of first facial hair 0.1 0.1 0.4 -0.0 -0.6 0.1 0.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 0.3 -0.8 -0.4 0.5
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.7 -0.7 0.8 0.7 -0.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 0.3 -0.4 -0.2 0.1
Systolic blood pressure, automated reading 0.3 1.0 1.4 1.0 -1.2 -0.9 0.8
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.7 0.7 -0.7 -0.8 0.6
Angina 0.1 0.1 0.3 0.0 0.6 -0.1 0.1
Medication for hormone replacement therapy 0.1 0.2 0.2 0.4 -0.1 -0.4 0.4
Vitamin and mineral supplements 0.1 0.1 0.2 0.4 0.1 -0.4 0.1
Supplements: Zinc 0.3 0.3 1.2 0.1 -1.1 -0.1 0.2
Medication: Co-codamol 0.1 0.1 0.2 0.4 -0.0 -0.4 0.2
Medication: Metformin 0.4 0.5 1.3 -0.3 1.1 0.3 -0.8
Diabetes (father) 1.8 2.2 2.7 -1.4 1.3 1.6 -1.6
Diabetes (mother) 0.2 0.3 0.5 0.6 -0.2 -0.7 0.5
Severe depression (siblings) 0.2 0.2 0.3 -0.6 -0.2 0.6 -0.4
Pack years adult smoking proportion 5.1 7.9 9.9 2.6 -3.1 -2.6 2.9
Impedance of leg (right) 0.6 2.8 3.3 -1.8 1.5 1.7 -1.5
Leg fat-free mass (left) 0.7 3.9 5.6 2.4 -0.5 -2.4 2.0
Trunk fat percentage 0.4 1.5 1.9 1.4 0.8 -1.4 1.2
Hand grip strength (right) 0.1 0.3 0.6 0.5 -0.1 -0.7 0.8
Townsend deprivation index at recruitment 0.5 0.6 1.0 0.6 -0.8 -0.7 1.0
Current tobacco smoking 0.1 0.2 0.4 0.2 -0.7 -0.2 0.4
Average weekly fortified wine intake 0.4 0.5 0.6 0.7 -0.6 -0.8 0.7
Maternal smoking around birth 0.4 0.5 1.1 -0.5 1.1 0.6 -0.5
Fed-up feelings 3.6 6.6 7.8 2.8 -2.0 -2.7 2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 0.1 0.3 -0.0 0.1
Relative age voice broke 0.9 1.4 2.3 1.0 -1.5 -0.9 1.2
Taking other prescription medications 0.9 1.3 1.6 1.3 -0.8 -1.2 1.2
Age when periods started (menarche) 1.8 4.4 4.7 2.0 -2.2 -2.1 2.1
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 2.5 -1.5 1.5 1.5 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 3.7 -0.4 1.9 0.3 -0.3
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 2.3 1.4 -0.6 -1.5 1.5
Qualifications: CSEs or equivalent 0.5 0.7 0.9 0.9 -0.5 -0.9 0.9
Serious illness, injury or assault to yourself 0.8 0.9 1.5 0.8 -1.2 -0.9 0.8
High blood pressure 0.4 1.1 2.7 0.7 -1.6 -0.8 0.8
Hayfever, allergic rhinitis or eczema 0.9 2.0 4.3 1.0 -2.1 -1.0 1.2
Multivitamins +/- minerals 0.4 0.5 0.7 -0.9 0.4 0.9 -0.5
Stomach or abdominal pain in last month 0.2 0.3 0.3 0.5 -0.5 -0.5 0.5
Supplements: Glucosamine 0.0 0.0 0.1 0.1 0.3 -0.0 -0.0
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 3.8 1.7 -2.0 -1.7 1.7
Medication: Atenolol 0.5 0.7 0.9 -0.9 0.6 0.9 -0.7
Medication: Levothyroxine sodium 1.2 2.0 3.8 1.1 -1.9 -1.2 1.4
Sitting height 0.6 4.1 6.1 2.4 0.5 -2.5 2.1
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 0.3 -0.2 -0.2 0.1
High blood pressure (mother) 0.3 0.4 0.6 -0.8 0.1 0.7 -0.7
Body mass index (BMI) 0.5 2.0 3.0 1.7 -0.1 -1.7 1.5
Impedance of leg (left) 0.7 3.6 4.0 -2.0 1.9 1.9 -1.8
Leg predicted mass (left) 0.7 3.5 5.2 2.2 -0.5 -2.3 1.9
Trunk fat mass 0.5 2.0 2.8 1.6 0.7 -1.7 1.4
Waist circumference 0.2 0.7 2.5 -0.0 1.6 0.0 -0.4
Number of incorrect matches in round 6.6 11.0 11.4 3.4 -3.4 -3.3 3.2
Past tobacco smoking 0.2 0.3 0.6 0.8 -0.1 -0.7 0.4
Alcohol usually taken with meals 0.4 0.6 1.0 -0.7 0.6 0.8 -1.0
Nervous feelings 0.0 0.0 0.1 0.0 0.3 0.1 -0.1
Frequency of tenseness / restlessness in last 2 weeks 2.9 4.5 4.7 2.2 -2.1 -2.1 2.2
Hearing difficulty/problems with background noise 0.6 0.9 1.3 1.2 -0.4 -1.1 0.9
Hair/balding pattern: Pattern 2 1.1 1.3 1.5 -1.1 1.1 1.2 -1.2
Had menopause 0.3 0.4 0.5 -0.6 0.5 0.6 -0.7
Had other major operations 0.1 0.1 0.5 0.2 -0.7 -0.1 0.2
Forced vital capacity (FVC) 0.4 1.4 1.7 -1.1 1.3 1.0 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 4.5 -0.2 2.1 0.1 -0.3
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 1.7 1.1 -1.3 -1.1 1.2
Qualifications: None of the above 0.0 0.1 0.2 -0.3 0.4 0.3 -0.1
Financial difficulties in last 2 years 0.3 0.3 0.6 -0.6 0.8 0.5 -0.4
Mouth/teeth dental problems 0.6 0.9 1.2 0.8 -1.1 -0.9 1.0
Heart attack 0.4 0.5 0.7 0.8 -0.2 -0.8 0.8
Allergy 0.2 0.3 1.2 -0.2 1.1 0.2 -0.3
Pain all over the body in last month 1.9 2.0 3.1 1.3 -1.8 -1.2 1.4
Diabetes (self-reported) 1.4 2.2 4.2 -1.1 2.0 1.1 -1.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.3 -0.0 -0.6 -0.1 0.3
Medication: Ramipril 0.0 0.0 0.1 0.1 -0.3 -0.1 0.2
Medication: Simvastatin 0.5 0.7 1.0 -1.0 0.6 0.9 -0.8
Fluid intelligence score 1.3 2.7 5.5 1.3 -2.3 -1.4 1.3
Illnesses of siblings 0.1 0.1 0.2 0.3 0.4 -0.3 0.3
Neuroticism score 1.3 2.8 3.6 1.9 -1.1 -1.8 1.7
Weight 0.5 2.5 3.9 1.9 0.4 -2.0 1.6
Impedance of arm (right) 0.5 2.6 3.0 -1.7 1.6 1.6 -1.4
Arm fat percentage (right) 0.5 1.9 2.7 1.6 -0.0 -1.6 1.5
Trunk fat-free mass 0.4 2.3 3.5 1.8 -0.5 -1.9 1.5
Hip circumference 0.7 2.8 4.0 1.9 -0.7 -2.0 1.7
Time employed in main current job 0.0 0.0 0.0 -0.2 -0.1 0.1 -0.0
Alcohol intake versus 10 years previously 0.9 1.4 2.7 -1.0 1.6 1.0 -0.8
Father’s age at death 3.4 4.6 5.8 -2.4 1.4 2.2 -2.4
Worrier / anxious feelings 1.3 2.4 3.2 1.8 -0.8 -1.7 1.7
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 3.6 1.2 -1.9 -1.1 1.3
Falls in the last year 2.8 3.7 4.2 -1.9 1.8 2.0 -2.0
Hair/balding pattern: Pattern 3 0.5 0.7 1.0 -1.0 0.6 1.0 -0.7
Number of live births 0.6 0.9 3.3 -0.3 1.8 0.3 -0.4
Forced expiratory volume in 1-second (FEV1) 1.9 6.3 7.0 -2.5 2.5 2.4 -2.6
Pulse rate 2.8 4.6 12.6 -1.3 3.5 1.3 -1.6
Happiness 0.8 0.9 1.9 0.7 -1.4 -0.7 0.8
Noisy workplace 0.1 0.1 0.2 0.3 -0.1 -0.4 0.4
Qualifications: A levels/AS levels or equivalent 0.2 0.5 2.0 -0.1 -1.4 0.1 -0.0
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.8 4.7 1.0 -2.2 -0.8 0.9
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.1 0.5 0.2 -0.3
Asthma 0.1 0.1 0.2 -0.5 -0.1 0.4 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.4 -0.2 -0.5 0.3
Medication: Cholesterol lowering 0.2 0.3 1.2 -0.2 1.1 0.2 -0.2
Depression (self-reported) 0.2 0.3 0.5 -0.6 -0.3 0.7 -0.4
Medication: Lansoprazole 0.3 0.3 0.5 0.6 0.2 -0.6 0.7
Prospective memory result 0.3 0.4 1.2 -0.3 1.1 0.3 -0.3
Lung cancer (father) 1.6 1.9 2.5 1.2 -1.6 -1.3 1.4
Illnesses of mother 0.9 1.2 1.3 1.1 -1.0 -1.1 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 6.2 -2.5 2.2 2.4 -2.5
Pulse wave Arterial Stiffness index 0.2 0.2 0.8 0.0 0.9 0.1 -0.1
Impedance of arm (left) 0.7 3.2 3.7 -1.8 1.9 1.7 -1.6
Arm fat mass (right) 0.5 2.2 3.2 1.8 0.2 -1.8 1.6
Trunk predicted mass 0.4 2.5 3.8 1.9 -0.6 -1.9 1.6
Standing height 0.1 0.6 1.9 0.5 1.4 -0.6 0.2
Length of working week for main job 0.1 0.2 0.6 -0.1 0.8 0.0 -0.1
Exposure to tobacco smoke at home 1.2 1.3 1.7 1.3 -0.5 -1.3 1.3
Breastfed as a baby 0.4 0.5 0.7 -0.8 0.5 0.8 -0.8
Tense / ‘highly strung’ 4.3 7.2 7.6 2.7 -2.8 -2.6 2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.9 0.8 -0.9 -0.7 0.8
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 0.6 -0.0 -0.5 0.5
Birth weight of first child 3.8 6.8 7.1 -2.6 2.6 2.6 -2.7
Peak expiratory flow (PEF) 0.6 1.4 1.9 -1.4 0.6 1.2 -1.3
Pulse wave reflection index 0.0 0.0 0.1 0.1 -0.3 -0.1 -0.1
Ever highly irritable/argumentative for 2 days 1.6 1.9 2.1 1.3 -1.4 -1.4 1.4
Loud music exposure frequency 0.7 0.8 1.0 -1.0 0.9 0.9 -0.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.4 -0.2 0.3 -0.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.5 -0.7 0.1 0.7 -0.6
Blood clot in the leg (DVT) 0.9 1.1 1.4 -1.2 0.6 1.2 -1.2
Medication: Paracetamol 1.2 2.0 2.2 1.4 -1.5 -1.4 1.4
Headache pain in last month 0.6 1.1 1.4 -1.2 0.8 1.1 -1.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.5 0.3 -1.2 -0.2 0.2
Glaucoma (self-reported) 0.0 0.1 0.2 -0.0 0.5 -0.0 -0.1
Gout (self-reported) 0.4 0.5 1.3 -0.6 1.1 0.5 -0.5
Hypothyroidism/myxoedema (self-reported) 1.7 3.3 6.9 1.3 -2.6 -1.4 1.6
Medication: Amlodipine 0.6 0.9 1.1 -1.0 0.8 1.0 -0.9
Medication: Ventolin 100micrograms inhaler 0.0 0.1 0.1 -0.2 0.2 0.3 -0.2
Birth weight 0.0 0.0 0.1 -0.3 -0.1 0.2 -0.1
Chronic bronchitis/emphysema (mother) 1.5 1.7 2.1 -1.4 1.0 1.4 -1.3
High blood pressure (siblings) 0.2 0.3 0.5 -0.5 0.3 0.6 -0.7
Forced vital capacity (FVC), Best measure 0.6 2.2 2.6 -1.5 1.4 1.4 -1.6
Body fat percentage 0.4 1.6 2.2 1.4 0.5 -1.5 1.3
Leg fat percentage (right) 0.2 0.7 1.1 1.0 0.3 -1.1 0.9
Arm fat-free mass (right) 0.7 3.8 5.8 2.4 -0.5 -2.4 1.9
Exposure to tobacco smoke outside home 0.0 0.0 0.0 -0.1 0.0 0.2 -0.0
Comparative body size at age 10 0.7 1.9 2.4 -1.5 1.0 1.5 -1.4
Number of full brothers 0.3 0.3 0.9 0.4 -0.9 -0.3 0.5
Worry too long after embarrassment 0.1 0.2 0.5 -0.1 0.7 0.1 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.7 0.9 -1.6 -0.9 0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 0.5 0.4 -0.4 0.4
Number of children fathered 0.0 0.0 0.1 -0.0 0.3 -0.0 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.5 1.2 -0.2 -1.1 0.9
Age at first live birth 0.1 0.2 0.7 0.0 -0.8 0.0 -0.3
Pulse wave peak to peak time 0.3 0.4 1.0 0.3 -1.0 -0.5 0.5
Health satisfaction 1.2 1.6 2.2 1.5 -0.6 -1.4 1.3
Shortness of breath walking on level ground 0.2 0.3 0.4 -0.5 0.3 0.6 -0.6
Qualifications: College or University degree 0.4 1.3 2.5 1.1 -1.6 -1.1 0.7
Eye problems/disorders: None of the above 0.3 0.3 1.1 0.0 -1.0 -0.1 0.4
Mouth/teeth dental problems: Loose teeth 5.4 6.4 6.9 -2.5 2.5 2.5 -2.6
Emphysema/chronic bronchitis 0.5 0.6 0.7 -0.7 0.7 0.8 -0.8
Medication for pain relief, constipation, heartburn 0.2 0.4 0.5 -0.7 0.3 0.7 -0.6
Neck or shoulder pain in last month 0.0 0.0 0.1 0.2 -0.0 -0.3 0.1
Medication: Blood pressure 0.0 0.0 0.1 0.2 0.1 -0.2 0.2
Angina (self-reported) 0.1 0.1 0.3 0.1 0.5 -0.1 0.1
Migraine (self-reported) 6.0 7.4 8.1 -2.7 2.7 2.7 -2.8
Medication: Ibuprofen 0.4 0.4 0.5 0.6 -0.6 -0.7 0.7
Medication: Allopurinol 0.6 0.8 2.1 -0.6 1.4 0.6 -0.6
Medication: Omeprazole 1.3 1.5 1.9 -1.3 1.0 1.4 -1.3
Medication: Seretide 50 evohaler 0.3 0.4 0.6 0.7 -0.3 -0.6 0.8
Mean time to correctly identify matches 0.7 1.3 2.4 0.9 -1.6 -0.9 1.0
Heart disease (mother) 0.4 0.5 0.8 -0.7 0.3 0.8 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.5 3.0 4.0 -1.6 2.0 1.6 -1.7
Whole body fat mass 0.5 2.2 3.3 1.8 0.5 -1.8 1.5
Leg fat mass (right) 0.5 1.8 2.7 1.6 0.4 -1.6 1.3
Arm predicted mass (right) 0.8 4.1 6.1 2.5 -0.5 -2.5 2.0
Pulse rate, automated reading 1.6 5.1 15.1 -1.1 3.9 1.2 -1.6
Alcohol intake frequency. 0.6 1.4 2.2 -1.0 1.5 1.0 -1.1
Comparative height size at age 10 0.0 0.1 0.2 0.2 0.5 -0.2 0.0
Number of full sisters 0.6 0.8 1.1 -1.1 0.5 1.1 -0.8
Suffer from ‘nerves’ 0.1 0.1 0.4 0.2 -0.6 -0.0 0.1
Overall health rating 0.0 0.1 0.2 0.4 0.4 -0.2 0.2
Chest pain or discomfort 0.3 0.5 0.5 0.6 -0.7 -0.6 0.7
Had major operations 2.2 2.6 3.1 1.4 -1.8 -1.5 1.7
Age at last live birth 0.3 0.5 0.7 0.7 -0.8 -0.7 0.4
Family relationship satisfaction 7.4 9.1 9.2 3.0 -3.0 -3.0 3.0
Leg pain on walking 0.7 0.9 1.1 -1.0 0.7 1.0 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.4 -0.1 0.6 0.1 -0.4
Commuting to job workplace: Car/motor vehicle 2.7 3.1 5.2 -1.5 2.3 1.5 -1.6
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.3 -0.3 0.6 0.3 -0.5
Medication: Aspirin 0.5 0.7 0.7 -0.9 0.8 0.8 -0.8
Supplements: Vitamin C 0.4 0.5 0.6 -0.7 0.5 0.8 -0.7
Knee pain experienced in last month 3.3 5.2 5.9 -2.3 2.0 2.4 -2.4
Hypertension (Self-reported) 0.2 0.6 1.7 0.4 -1.3 -0.4 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 4.2 -1.6 2.1 1.5 -1.4
Illnesses of father: Heart disease 0.1 0.1 0.2 -0.4 -0.2 0.4 -0.4
Illnesses of siblings: Diabetes 1.3 1.7 2.6 1.1 -1.6 -1.2 1.1
Smoking status: Previous 0.7 1.1 1.6 -1.3 0.8 1.1 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 0.3 0.3 -0.3 0.3
Whole body fat-free mass 0.6 3.4 5.1 2.2 -0.5 -2.2 1.8
Leg fat-free mass (right) 0.6 3.1 4.7 2.2 -0.3 -2.2 1.8
Arm fat percentage (left) 0.4 1.8 2.6 1.6 0.3 -1.6 1.4
Average weekly red wine intake 0.0 0.0 0.0 -0.1 -0.1 -0.0 -0.1
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.1 1.0 -0.3 -0.9 0.8
Mood swings 1.8 3.3 3.8 1.9 -1.4 -1.9 1.9
Loneliness, isolation 1.4 1.9 2.5 1.3 -1.3 -1.3 1.6
Long-standing illness, disability or infirmity 0.3 0.5 0.7 -0.7 0.5 0.7 -0.8
Ever had bowel cancer screening 0.2 0.2 0.7 -0.1 -0.8 0.0 -0.1
Diabetes diagnosed by doctor 0.5 0.9 2.5 -0.4 1.6 0.4 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.6 -0.7 0.8 0.7 -0.6
Friendships satisfaction 8.0 9.9 12.2 3.0 -3.5 -3.0 3.0
Qualifications: nursing, teaching 4.3 6.6 7.6 2.5 -2.8 -2.6 2.5
Commuting to job workplace: Walk 3.9 4.2 6.3 1.9 -2.5 -1.8 1.9
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.2 0.3 -0.1 -0.1
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 3.8 -1.7 1.9 1.7 -1.9
Medication for cholesterol 0.3 0.4 0.6 0.8 -0.4 -0.7 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 2.9 1.7 -0.8 -1.6 1.4
Back pain experienced in last month 1.0 1.4 2.0 -1.1 1.4 1.1 -1.2
Mineral and other dietary supplements 0.5 0.6 0.8 0.8 -0.9 -0.8 0.7
Breast cancer (self-reported) 0.4 0.4 0.7 -0.5 0.9 0.5 -0.6
Asthma (self-reported) 0.1 0.1 0.3 -0.5 -0.0 0.5 -0.2
Osteoporosis (self-reported) 8.1 10.0 12.7 2.9 -3.6 -3.0 3.2
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.4 0.8 0.5 -0.7
Medication: Aspirin 0.4 0.6 0.7 -0.8 0.6 0.8 -0.8
Medication: Gliclazide 0.0 0.1 0.1 -0.2 -0.3 0.2 -0.2
Illnesses of father: None of the above (group 1) 0.1 0.1 0.1 0.2 0.3 -0.2 0.3
Smoking status: Current 0.2 0.4 0.5 0.5 -0.7 -0.5 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 2.9 -1.3 1.7 1.3 -1.6
Whole body water mass 0.6 3.6 5.3 2.3 -0.6 -2.3 1.9
Leg predicted mass (right) 0.6 3.3 4.9 2.2 -0.3 -2.2 1.8
Arm fat mass (left) 0.6 2.3 3.4 1.8 0.3 -1.9 1.6
Number of self-reported non-cancer illnesses 0.2 0.4 1.4 -0.0 -1.2 -0.0 0.2
Average weekly champagne plus white wine intake 0.7 0.9 1.2 1.1 -0.9 -1.0 0.8
Miserableness 4.6 7.9 9.1 3.0 -2.3 -3.0 3.0
Guilty feelings 0.1 0.1 0.2 -0.4 0.4 0.4 -0.3
Wears glasses or contact lenses 0.7 0.8 1.1 1.1 -0.5 -1.1 0.9
Ever taken oral contraceptive pill 1.3 1.5 1.8 1.1 -1.3 -1.2 1.2
Hearing aid user 0.4 0.5 0.7 -0.6 0.9 0.6 -0.7
Mother’s age at death 0.6 0.7 1.1 -0.8 0.6 0.9 -1.1
Financial situation satisfaction 2.1 2.5 3.1 1.7 -1.2 -1.7 1.7
Tinnitus: Yes, now most or all of the time 2.4 2.8 3.2 -1.6 1.8 1.6 -1.6
Commuting to job workplace: Public transport 0.3 0.4 0.6 0.7 -0.8 -0.5 0.6
Eye problems/disorders: Glaucoma 0.2 0.2 0.7 0.2 0.8 -0.2 0.0
Medication: Blood pressure 0.2 0.4 0.6 -0.7 -0.3 0.8 -0.7
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.4 0.6 0.4 -0.6 0.4
Supplements: Fish oil (including cod liver oil) 1.3 1.8 2.2 -1.5 1.3 1.3 -1.2
High cholesterol (Self-reported) 0.8 1.5 1.8 -1.3 1.3 1.2 -1.1
Medication: Bendroflumethiazide 0.1 0.2 0.6 0.4 -0.8 -0.3 0.3
Medication: Paracetamol 3.3 5.1 6.1 2.1 -2.5 -2.1 2.3
Medication: Lisinopril 0.1 0.1 0.1 -0.4 -0.3 0.3 -0.2
Medication: Atorvastatin 0.1 0.1 0.3 -0.2 0.5 0.2 -0.4
Illnesses of father: High blood pressure 0.7 0.8 1.2 -1.1 0.6 0.9 -1.0
Alcohol drinker status: Never 1.2 1.4 1.7 -1.0 1.2 1.1 -1.3
Ever smoked 0.1 0.2 0.7 0.1 -0.8 -0.2 0.5
Basal metabolic rate 0.6 3.4 5.1 2.2 -0.4 -2.3 1.9
Leg fat percentage (left) 0.2 0.8 1.2 1.0 0.4 -1.1 0.9
Arm fat-free mass (left) 1.1 5.7 7.9 2.8 -1.1 -2.8 2.5
Number of operations (self-reported) 1.4 2.0 3.0 1.3 -1.7 -1.3 1.3
Average weekly beer plus cider intake 0.4 0.6 0.9 0.9 0.2 -0.9 0.9
Irritability 4.5 7.7 7.8 2.8 -2.8 -2.8 2.8
Risk taking 0.6 0.9 1.0 -0.9 1.0 0.9 -0.8
Ever had prostate specific antigen (PSA) test 1.9 2.2 3.5 -1.3 1.9 1.3 -1.3
Fractured/broken bones in last 5 years 0.6 0.7 2.0 0.5 -1.4 -0.5 0.6
Age started oral contraceptive pill 0.0 0.0 0.1 0.1 0.0 -0.0 -0.4
Diastolic blood pressure, automated reading 0.3 1.1 1.5 1.2 -0.8 -1.1 0.9
Ever depressed for a whole week 0.7 0.8 2.1 0.5 -1.4 -0.5 0.8
Unable to work because of sickness or disability 0.5 0.7 1.0 -0.9 -0.2 1.0 -0.9
Commuting to job workplace: Cycle 0.6 0.8 0.9 1.0 -0.9 -0.9 0.7
Myopia 2.5 3.7 4.6 1.8 -2.2 -1.9 1.8
Vascular/heart problems diagnosed by doctor 0.8 2.3 3.3 -1.3 1.8 1.4 -1.4
Cholesterol lowering medication 0.3 0.4 0.5 -0.7 0.5 0.6 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.7 -0.8 0.6 0.8 -0.7
Pain experienced in last month 0.3 0.6 0.9 0.7 -0.9 -0.7 0.7
Supplements: Calcium 0.0 0.1 0.2 -0.1 -0.5 0.1 -0.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.3 -0.4 -0.4 0.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.6 0.7 -0.2 -0.7 0.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 -0.8 0.1 0.8 -0.7
Heart disease (siblings) 0.3 0.4 0.6 0.6 -0.6 -0.6 0.8
Alcohol drinker status: Previous 0.5 0.5 0.8 -0.7 0.3 0.9 -0.9
Pack years of smoking 3.5 5.1 7.2 2.0 -2.7 -2.0 2.3
Impedance of whole body 0.9 4.6 5.2 -2.2 2.3 2.1 -2.0
Leg fat mass (left) 0.5 2.0 3.1 1.7 0.4 -1.8 1.4
Arm predicted mass (left) 0.6 3.0 4.5 2.1 -0.5 -2.1 1.7