TWAS hub - TMEM101

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.124	0.0416	0.00029	0.033	NA	0.048	NA	0.032	0.00031	NA	1.6e-05	NA	0.00038
2	GTEx	Skin Sun Exposed Lower leg	0.178	0.0610	0.00095	0.017	NA	0.015	NA	0.008	0.01400	NA	1.9e-02	NA	0.06600
3	TCGA	Thyroid Carcinoma	0.049	0.0300	0.00570	-0.001	0.018	0.028	NA	0.002	0.49000	0.006	9.5e-04	NA	0.20000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Happiness	7.8	9.4	11.0	3.3	2.9	3.0
Osteoarthritis (self-reported)	6.8	8.8	12.5	-3.5	-2.6	-2.7
Tinnitus: Yes, but not now, but have in the past	6.1	6.6	7.2	2.7	2.5	2.5
Supplements: Glucosamine	5.9	7.7	11.7	-2.5	-3.4	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.7	6.6	8.7	-3.0	-2.5	-2.3
Medication: Lansoprazole	5.4	6.2	6.8	-2.6	-2.4	-2.5
Mouth/teeth dental problems: Loose teeth	4.8	5.7	7.2	-2.2	-2.3	-2.7
Triglycerides	4.4	7.1	8.9	2.5	3.0	2.5
Had major operations	4.3	5.1	7.5	-1.7	-2.2	-2.7
Ever used hormone-replacement therapy (HRT)	3.9	4.9	7.2	-2.7	-1.8	-2.0
Medication: Lisinopril	3.8	4.9	6.6	2.0	2.6	2.0
Medication: Bendroflumethiazide	3.6	5.5	7.1	2.5	1.8	2.7
Allergy	3.2	7.4	8.1	-2.8	-2.5	-2.8
Supplements: Zinc	3.1	3.4	4.6	2.1	1.1	2.1
Major Depression (MDD)	3.0	3.6	8.5	1.2	2.9	0.9
Number of incorrect matches in round	3.0	5.1	9.2	-3.0	-1.5	-1.9
Heart disease (mother)	2.9	3.5	5.5	2.3	1.6	1.6
Ever smoked	2.9	5.0	7.3	2.5	1.3	2.7
Medication for hormone replacement therapy	2.8	3.1	7.0	-2.6	-1.0	-1.2
Medication: Aspirin	2.7	3.5	5.4	-1.6	-2.3	-1.6
Comparative height size at age 10	2.6	14.4	28.8	-5.4	-2.8	-2.6
Ever had bowel cancer screening	2.6	3.0	4.0	-1.5	-2.0	-1.7
Ever had prostate specific antigen (PSA) test	2.6	3.0	5.7	-2.4	-1.1	-1.5
Hayfever/allergic rhinitis (self-reported)	2.5	3.2	7.6	0.8	2.8	1.2
Illnesses of mother	2.5	3.1	3.7	-1.9	-1.6	-1.8
Heel T-Score	2.4	19.2	47.5	-6.9	-3.1	-0.7
Mineral and other dietary supplements	2.4	3.2	4.7	1.1	2.2	1.9
Hayfever, allergic rhinitis or eczema	2.3	5.1	6.1	2.1	2.5	2.2
Headache pain in last month	2.3	3.9	7.4	2.7	1.4	1.6
Financial difficulties in last 2 years	2.2	2.9	6.1	2.5	-0.2	1.6
Mother’s age at death	2.2	2.8	4.3	-1.1	-1.7	-2.1
Medication: Atorvastatin	2.2	2.8	4.4	1.7	1.0	2.1
Alcohol drinker status: Previous	2.1	2.4	2.7	1.6	1.6	1.4
Pain all over the body in last month	2.0	2.1	6.2	-0.5	0.0	-2.5
Number of full brothers	2.0	2.5	2.8	-1.7	-1.4	-1.7
Alcohol intake frequency.	2.0	4.7	8.1	2.9	1.4	2.0
Chronotype (morning person)	1.9	4.4	4.7	-2.1	-2.2	-2.0
Frequency of depressed mood in last 2 weeks	1.9	2.6	5.6	2.4	0.0	1.5
Had menopause	1.9	2.4	4.2	-1.0	-1.5	-2.0
Trunk fat-free mass	1.9	10.7	12.1	-3.5	-3.2	-3.1
Number of children fathered	1.9	2.1	6.0	0.0	2.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	5.4	2.3	1.1	0.3
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	4.2	-1.3	-2.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.0	2.0	0.8	1.6
Weight	1.8	8.6	12.2	-3.5	-2.8	-2.5
Trunk predicted mass	1.8	10.5	12.0	-3.5	-3.2	-3.1
Arm fat-free mass (right)	1.8	9.5	12.5	-3.5	-2.9	-2.7
Commuting to job workplace: Walk	1.8	2.0	3.3	1.6	1.8	0.0
Number of operations (self-reported)	1.8	2.7	3.7	-0.9	-1.9	-1.9
Fasting Glucose	1.7	2.0	2.5	1.2	1.5	1.6
Lung cancer (father)	1.7	2.0	3.1	-1.8	-0.7	-1.6
Arm predicted mass (right)	1.7	8.7	11.2	-3.4	-2.8	-2.6
Suffer from ‘nerves’	1.7	2.7	5.9	-1.2	-2.4	-0.9
Smoking status: Current	1.7	2.7	4.1	2.0	0.9	1.8
Current tobacco smoking	1.6	2.7	4.2	2.1	0.8	1.8
Taking other prescription medications	1.6	2.4	2.8	-1.7	-1.4	-1.6
Birth weight	1.6	3.6	4.8	1.8	2.2	1.6
Whole body fat-free mass	1.6	9.3	11.2	-3.4	-3.0	-2.7
High cholesterol (Self-reported)	1.6	2.8	3.4	1.8	1.6	1.6
Basal metabolic rate	1.6	9.0	11.4	-3.4	-3.0	-2.6
Type 2 Diabetes (T2D) (2012)	1.5	1.8	2.5	1.0	1.6	1.3
Townsend deprivation index at recruitment	1.5	2.1	5.0	2.2	1.2	-0.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.5	-1.3	-1.9	-0.3
Waist circumference	1.5	5.4	6.0	-2.2	-2.4	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.3	6.8	-2.6	-1.8	0.2
Hip circumference	1.5	6.3	7.2	-2.7	-2.2	-2.6
Whole body water mass	1.5	8.5	10.7	-3.3	-2.9	-2.6
Heart disease (siblings)	1.5	1.9	3.7	-1.9	-0.1	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.5	1.9	0.3	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.8	2.0	0.6	1.1
Medication: Omeprazole	1.4	1.7	3.5	-0.9	-1.9	-0.9
Friendships satisfaction	1.4	1.8	2.4	1.4	1.6	1.1
Depression (Nagel 2018)	1.3	1.9	3.2	1.8	0.7	1.4
Number of treatments/medications taken	1.3	2.3	3.1	-1.3	-1.8	-1.4
Number of live births	1.3	1.8	2.8	1.1	1.7	1.2
Financial situation satisfaction	1.3	1.6	2.0	1.4	1.4	1.0
Arm fat-free mass (left)	1.3	6.7	8.6	-2.9	-2.5	-2.3
Arm predicted mass (left)	1.3	6.8	9.1	-3.0	-2.4	-2.4
Respiratory disease	1.2	2.7	5.8	1.4	2.4	0.7
Leg fat-free mass (left)	1.2	6.5	8.6	-2.9	-2.6	-2.0
Serious illness, injury or assault to yourself	1.2	1.5	3.2	1.8	1.0	0.5
Impedance of arm (right)	1.2	5.5	9.3	1.4	2.3	3.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.2	0.8	1.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.0	-1.0	-1.4	-1.1
Fractured/broken bones in last 5 years	1.2	1.6	4.2	2.1	0.5	-0.6
Alzheimer’s Disease (in father)	1.1	1.2	2.5	-0.8	-1.6	-0.7
BMI	1.1	6.6	9.4	-3.1	-2.1	-2.5
Diabetes (father)	1.1	1.4	1.7	-1.3	-1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.0	-2.2	-1.2	0.9
Leg predicted mass (left)	1.1	6.0	8.0	-2.8	-2.5	-1.9
Medication: Ramipril	1.1	1.5	2.7	-1.2	-1.6	-0.6
Pulse wave reflection index	1.1	1.4	2.9	1.0	1.7	0.6
Whole body fat mass	1.1	4.4	7.8	-2.8	-1.8	-1.5
Leg fat mass (right)	1.1	4.3	6.4	-2.5	-1.7	-1.9
Leg fat-free mass (right)	1.1	5.7	7.5	-2.7	-2.5	-1.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.2	0.2	0.9	1.8
Leg fat mass (left)	1.1	4.1	6.7	-2.6	-1.6	-1.8
Reaction Time	1.0	1.9	2.9	1.7	0.1	1.7
HbA1C	1.0	1.1	3.0	-0.4	-1.7	-0.5
Medication: Atenolol	1.0	1.3	2.0	-0.8	-1.4	-1.1
Noisy workplace	1.0	1.2	2.8	-0.8	-0.5	-1.7
Impedance of arm (left)	1.0	4.7	8.1	0.9	2.3	2.9
Standing height	1.0	10.0	22.4	-4.7	-2.4	-1.3
Tense / ‘highly strung’	1.0	1.7	4.9	0.3	-2.2	-0.0
Blood clot in the leg (DVT)	1.0	1.3	2.3	0.9	0.8	1.5
Leg predicted mass (right)	1.0	5.6	7.5	-2.7	-2.4	-1.9
Miserableness	1.0	1.7	3.6	1.9	0.6	1.1
Supplements: Calcium	1.0	1.1	2.0	-0.4	-1.4	-1.1
Impedance of whole body	1.0	4.9	8.2	0.9	2.4	2.9
Trunk fat mass	0.9	3.8	7.8	-2.8	-1.6	-0.9
Father’s age at death	0.9	1.2	2.4	-0.9	-1.5	-0.5
Pulse rate	0.9	1.5	3.0	1.7	-1.1	-0.2
Medication: Aspirin	0.9	1.2	2.2	-0.8	-1.5	-0.8
Medication: Gliclazide	0.9	1.0	2.5	-1.6	-0.1	-0.8
Arm fat mass (left)	0.9	3.5	5.7	-2.4	-1.6	-1.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.4	-1.2	-1.0	-1.1
Alcohol drinker status: Never	0.9	1.0	1.3	0.8	1.1	1.1
Bipolar Disorder (2018)	0.8	1.3	3.8	-1.9	-0.1	0.3
Mean Putamen Volume	0.8	0.9	2.6	1.6	-0.1	-0.4
LDL Cholesterol	0.8	1.2	2.3	0.6	1.5	1.0
Blood Platelet Count	0.8	9.0	24.5	0.7	1.4	5.0
Smoking Status	0.8	1.8	3.2	1.4	0.4	1.8
Severe depression (siblings)	0.8	0.9	2.2	0.3	-1.5	-0.5
Body mass index (BMI)	0.8	3.3	3.9	-1.7	-1.8	-2.0
Impedance of leg (left)	0.8	3.7	5.3	0.7	2.3	2.3
Arm fat mass (right)	0.8	3.3	5.4	-2.3	-1.5	-1.5
Emphysema/chronic bronchitis	0.8	0.9	1.1	-1.0	-0.9	-1.0
Medication for pain relief, constipation, heartburn	0.8	1.4	3.1	0.9	1.7	0.6
Migraine (self-reported)	0.8	1.0	1.5	0.6	1.1	1.2
Chest pain or discomfort	0.8	1.1	2.9	1.7	0.2	0.7
Loneliness, isolation	0.8	1.0	2.9	1.7	-0.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	-0.6	-0.8	-1.4
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.6	1.6	-0.6	-0.1
Unable to work because of sickness or disability	0.8	1.0	1.6	1.3	0.7	0.9
Prostate Cancer	0.7	1.0	2.3	-0.7	-1.5	-0.5
Hand grip strength (left)	0.7	1.8	2.9	-1.7	-1.4	-0.8
Systolic blood pressure, automated reading	0.7	2.2	4.9	-2.2	-0.4	-1.2
Impedance of leg (right)	0.7	3.3	5.3	0.7	2.1	2.3
Maternal smoking around birth	0.7	1.1	2.9	0.5	0.2	-1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	-1.2	-0.9	-0.0
Chronic bronchitis/emphysema (father)	0.7	0.8	2.1	-0.1	0.5	-1.5
Hair/balding pattern: Pattern 2	0.7	0.9	2.4	0.0	1.6	0.6
Had other major operations	0.7	0.8	1.7	1.3	0.9	0.2
Alcohol intake versus 10 years previously	0.7	1.0	2.3	0.9	-1.5	0.1
Asthma	0.7	1.3	1.9	1.1	1.4	1.0
Length of working week for main job	0.7	0.8	1.0	-0.7	1.0	0.9
Hair/balding pattern: Pattern 4	0.7	1.6	3.0	1.2	-1.7	-0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.9	0.5	1.4	0.7
Pulse wave peak to peak time	0.7	0.8	2.3	-1.5	-0.3	0.0
Qualifications: College or University degree	0.7	2.3	5.0	1.4	0.4	2.2
Risk taking	0.7	1.0	3.0	0.3	-1.7	-0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.5	1.2	0.7
Crohns Disease (2017)	0.6	1.3	2.1	1.5	1.1	0.6
Irritable Bowel Disease (IBD)	0.6	1.4	2.4	1.0	1.6	0.9
Height	0.6	10.8	26.3	-5.1	-1.9	-1.5
Systolic Blood Pressure	0.6	2.9	5.3	0.4	1.8	2.3
Allergy or Eczema	0.6	1.5	2.4	1.2	1.5	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	-0.9	-0.9	-0.6
Hand grip strength (right)	0.6	1.7	3.8	-2.0	-0.7	-0.9
Fed-up feelings	0.6	1.0	2.0	1.4	-0.1	1.1
Multivitamins +/- minerals	0.6	0.8	1.9	-0.7	-1.4	0.1
Qualifications: None of the above	0.6	1.2	3.2	-0.5	-0.4	-1.8
Mouth/teeth dental problems	0.6	0.9	2.2	-0.3	0.7	1.5
Medication: Paracetamol	0.6	0.9	1.2	1.1	0.6	1.1
Comparative body size at age 10	0.6	1.7	3.6	-0.2	-1.2	-1.9
Leg pain on walking	0.6	0.7	1.4	-0.5	-0.8	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.4	-1.2	0.3	-0.9
Supplements: Vitamin C	0.6	0.7	2.0	-0.0	0.2	1.4
Illnesses of siblings: Diabetes	0.6	0.8	1.7	-0.1	-1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	1.0	0.9	0.3
Illnesses of father: High blood pressure	0.6	0.8	1.5	0.9	0.1	1.2
Irritability	0.6	1.0	1.3	-1.2	-0.7	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.5	0.5	0.8	1.2
Neuroticism (Nagel 2018)	0.5	1.2	3.2	-0.4	-1.8	-0.5
Age at First Birth	0.5	0.8	1.4	0.5	-1.2	0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	1.0	-1.0	-0.2
Stomach or abdominal pain in last month	0.5	0.7	1.6	1.3	-0.6	0.3
High blood pressure (mother)	0.5	0.7	1.9	0.3	-1.4	-0.3
Past tobacco smoking	0.5	0.9	1.6	-1.0	-0.2	-1.3
Hearing difficulty/problems with background noise	0.5	0.9	1.6	1.3	-0.9	-0.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	1.2	0.7	0.4
Leg fat percentage (right)	0.5	1.7	2.4	-1.6	-1.0	-1.3
Age at last live birth	0.5	0.7	1.6	0.2	0.6	1.2
Family relationship satisfaction	0.5	0.6	1.3	0.6	1.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.7	-0.6	-0.8	-0.9
Illnesses of father: Heart disease	0.5	0.8	1.1	0.9	1.1	0.6
Qualifications: nursing, teaching	0.5	0.8	2.0	0.2	0.6	1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.2	0.3	-0.5	-1.5
Back pain experienced in last month	0.5	0.7	1.5	1.2	0.7	0.3
Asthma (self-reported)	0.5	1.1	1.7	0.9	1.3	0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-0.6	-1.3	-0.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	-1.2	-0.2	0.5
Worry (Nagel 2018)	0.4	0.9	2.5	-0.6	-1.6	0.1
Cardiovascular Disease	0.4	1.5	3.1	1.0	0.6	1.8
Average weekly spirits intake	0.4	0.5	0.8	0.7	0.4	0.9
Relative age of first facial hair	0.4	0.9	1.5	0.9	0.6	1.2
Vitamin and mineral supplements	0.4	0.6	1.2	0.7	0.3	-1.1
Diabetes (mother)	0.4	0.6	1.1	1.1	0.4	0.7
Trunk fat percentage	0.4	1.6	4.3	-2.1	-0.7	-0.2
Average weekly fortified wine intake	0.4	0.5	1.1	1.1	-0.3	0.6
Nervous feelings	0.4	0.7	1.5	-0.8	-1.2	0.3
Illnesses of siblings	0.4	0.6	1.2	0.4	0.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.2	0.2	-1.1	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.7	0.9	-0.1	0.8
Glaucoma (self-reported)	0.4	0.5	0.9	-0.9	-0.6	-0.6
Worry too long after embarrassment	0.4	0.7	1.3	-0.3	-1.1	-0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	-1.1	0.1	-1.0
Age at first live birth	0.4	0.8	2.2	0.0	-0.2	1.5
Health satisfaction	0.4	0.6	1.2	-0.6	-0.4	-1.1
Mean time to correctly identify matches	0.4	0.7	1.7	1.3	-0.3	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	0.9	0.4	-0.5
Osteoporosis (self-reported)	0.4	0.5	1.2	0.6	-0.3	-1.1
Guilty feelings	0.4	0.6	1.3	1.2	-0.3	0.5
Hearing aid user	0.4	0.5	0.8	0.4	0.7	-0.9
Leg fat percentage (left)	0.4	1.4	2.1	-1.5	-0.8	-1.2
Commuting to job workplace: Cycle	0.4	0.5	1.2	-0.4	-0.2	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	1.3	-0.4	1.1
Ulcerative Colitis (UC)	0.3	0.5	1.1	0.2	1.0	0.6
Breast Cancer	0.3	0.6	0.9	0.8	0.9	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.7	0.8	-0.5
Coronary Artery Disease (CAD)	0.3	0.4	0.8	0.5	0.9	-0.4
Rheumatoid Arthritis	0.3	0.4	0.7	-0.4	-0.8	0.7
Blood Red Count	0.3	2.9	8.0	2.8	0.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.4	0.6	-0.6	0.7
Medication: Co-codamol	0.3	0.4	0.8	-0.9	0.4	-0.4
Relative age voice broke	0.3	0.4	0.8	0.9	0.2	0.5
High blood pressure	0.3	0.9	2.3	0.3	-1.5	-0.4
Diabetes (self-reported)	0.3	0.5	0.9	-0.5	-0.9	-0.6
Arm fat percentage (right)	0.3	1.3	2.2	-1.5	-0.9	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.5	-0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.3	-1.1	-0.3	1.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	1.0	-0.1	-0.2
Breastfed as a baby	0.3	0.4	1.0	0.0	1.0	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	1.0	0.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.9	-0.5	-0.4	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	-0.2	-0.0	-1.2
Medication: Amlodipine	0.3	0.4	0.7	0.8	-0.1	0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	1.7	-1.0	-0.4	1.3
Body fat percentage	0.3	1.3	3.2	-1.8	-0.7	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.1	-1.0	0.3
Medication: Ibuprofen	0.3	0.4	0.5	0.6	-0.7	0.5
Pulse rate, automated reading	0.3	1.1	1.4	0.7	-1.2	-1.1
Overall health rating	0.3	0.7	1.6	0.3	-0.7	-1.3
Arm fat percentage (left)	0.3	1.4	2.5	-1.6	-0.9	-0.9
Mood swings	0.3	0.5	1.5	0.3	-1.2	0.1
Breast cancer (self-reported)	0.3	0.3	0.5	-0.0	0.7	0.7
Diastolic blood pressure, automated reading	0.3	0.8	1.2	-0.8	-0.7	-1.1
Ever depressed for a whole week	0.3	0.4	0.8	0.6	-0.9	0.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	1.1	-0.3	0.1
Schizophrenia (2018)	0.2	0.4	0.6	0.8	-0.6	0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.4	-0.6	-0.3
Ovarian Cancer	0.2	0.2	0.5	0.7	0.3	0.4
Crohns Disease (2012)	0.2	0.3	0.6	0.8	0.6	0.2
Neuroticism (2016)	0.2	0.2	0.3	0.5	-0.3	0.6
Primary Biliary Cirrhosis	0.2	0.2	0.7	0.1	0.8	0.0
Blood Eosinophil Count	0.2	1.8	4.8	-2.2	-0.4	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.2	-0.9	-0.7
Medication: Metformin	0.2	0.2	0.6	-0.8	-0.3	-0.0
Pack years adult smoking proportion	0.2	0.3	0.6	-0.5	0.3	0.8
Qualifications: CSEs or equivalent	0.2	0.3	0.7	-0.4	-0.8	0.2
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.4	0.4	-0.7
Alcohol usually taken with meals	0.2	0.3	0.5	0.7	-0.2	0.6
Forced vital capacity (FVC)	0.2	0.7	1.4	-1.2	0.3	0.7
Medication: Simvastatin	0.2	0.3	0.5	-0.5	-0.5	-0.7
Neuroticism score	0.2	0.4	0.7	0.8	-0.1	0.6
Worrier / anxious feelings	0.2	0.4	1.3	-0.2	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.9	-1.4	0.2	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.4	0.6	-0.6
Medication: Cholesterol lowering	0.2	0.3	0.5	0.3	0.7	0.4
Depression (self-reported)	0.2	0.2	0.5	0.3	-0.7	0.1
Loud music exposure frequency	0.2	0.2	0.5	0.7	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.4	0.5	0.6	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.5	-0.8	-0.2
Neck or shoulder pain in last month	0.2	0.3	0.7	-0.1	-0.4	0.8
Medication: Blood pressure	0.2	0.3	0.6	0.3	-0.5	0.8
Medication: Allopurinol	0.2	0.3	0.4	-0.5	-0.4	-0.7
Number of full sisters	0.2	0.3	0.6	0.6	0.0	0.8
Knee pain experienced in last month	0.2	0.2	0.4	-0.6	0.6	0.1
Hypertension (Self-reported)	0.2	0.6	1.8	0.2	-1.4	-0.2
Average weekly red wine intake	0.2	0.3	0.9	0.1	-1.0	0.1
Diabetes diagnosed by doctor	0.2	0.4	0.8	-0.0	-0.9	-0.5
Medication for cholesterol	0.2	0.3	0.4	0.6	0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	-0.5	-0.9	0.6
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.7	-0.4	-0.0
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.6	0.5	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	0.8	0.2	0.2
Age started oral contraceptive pill	0.2	0.3	0.6	-0.6	-0.1	-0.8
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.8	-0.8	0.9	-0.4
Pack years of smoking	0.2	0.4	1.0	-1.0	0.0	0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.7	-0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	0.5	-0.5	0.2
Lupus	0.1	0.2	0.3	-0.6	-0.1	-0.5
Ulcerative Colitis	0.1	0.2	0.3	0.5	0.5	0.2
Blood White Count	0.1	1.1	1.8	-1.3	-0.5	1.1
Waist Hip Ratio (WHR)	0.1	0.5	1.2	-0.3	-1.1	0.4
Hypothyroidism (self reported)	0.1	0.3	0.4	0.6	0.2	-0.6
Lung FEV1/FVC ratio	0.1	0.5	1.1	-0.6	1.1	0.4
Lung FVC	0.1	0.4	1.2	0.1	0.3	1.1
Neuroticism	0.1	0.2	0.6	0.2	-0.8	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.7	0.0	-0.1	0.8
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.0	0.1	0.8
Angina	0.1	0.1	0.2	-0.4	-0.1	0.5
Sitting height	0.1	0.6	1.8	-1.4	-0.3	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.5	0.1	0.4
Fluid intelligence score	0.1	0.3	0.4	0.7	-0.5	0.5
Time employed in main current job	0.1	0.1	0.3	-0.6	-0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.5	0.1	0.2
Falls in the last year	0.1	0.1	0.2	-0.0	0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.7	-0.3	0.3
Prospective memory result	0.1	0.2	0.3	-0.2	0.6	-0.4
Birth weight of first child	0.1	0.2	0.4	0.1	0.5	0.6
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.8	-0.4	-0.1
Gout (self-reported)	0.1	0.1	0.3	-0.5	0.0	0.2
High blood pressure (siblings)	0.1	0.2	0.5	0.7	0.2	0.1
Shortness of breath walking on level ground	0.1	0.2	0.3	0.6	0.4	0.1
Angina (self-reported)	0.1	0.2	0.3	-0.3	0.2	0.6
Smoking status: Previous	0.1	0.1	0.3	-0.3	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.9	-0.2	-0.2	0.9
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.7	-0.1	0.3
Eye problems/disorders: Cataract	0.1	0.1	0.4	-0.6	0.2	0.2
Wears glasses or contact lenses	0.1	0.1	0.2	0.4	-0.3	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.1	-0.1	0.6
Medication: Blood pressure	0.1	0.3	0.4	0.7	0.1	0.6
Average weekly beer plus cider intake	0.1	0.2	0.5	0.2	0.7	0.1
Cholesterol lowering medication	0.1	0.1	0.4	0.3	-0.6	-0.0
Pain experienced in last month	0.1	0.1	0.2	-0.3	-0.4	0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.2	-0.0	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.2	-0.0	0.1
Schizophrenia (2014)	0.0	0.1	0.2	0.2	-0.1	0.4
Hair Pigment	0.0	0.2	0.7	-0.8	0.0	-0.1
Tanning	0.0	0.3	0.9	0.1	1.0	0.0
Age when periods started (menarche)	0.0	0.1	0.1	0.1	-0.2	-0.3
Heart attack	0.0	0.0	0.1	0.0	-0.2	-0.3
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	-0.1	-0.2
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.2	-0.3	-0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.1	-0.2	0.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.0	-0.0	-0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.2	-0.3	-0.1
Medication: Paracetamol	0.0	0.0	0.0	-0.2	-0.1	0.2
Myopia	0.0	0.0	0.0	-0.0	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.3	0.0	0.1

Hub : Genes

TMEM101

Models

Trait associations