Hub : Genes

TMEM143

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.195	0.0520	0.00002	0.132	NA	0.121	NA	0.130	1.7e-10	NA	1.1e-09	NA	2.4e-10
2	GTEx	Esophagus Muscularis	0.165	0.0610	0.00500	0.110	NA	0.090	NA	0.103	3.6e-07	NA	4.2e-06	NA	8.5e-07
3	GTEx	Lung	0.174	0.0496	0.00033	0.061	NA	0.004	NA	0.018	1.9e-05	NA	1.4e-01	NA	1.5e-02
4	GTEx	Nerve Tibial	0.140	0.0417	0.00022	0.103	NA	0.090	NA	0.087	1.0e-07	NA	6.6e-07	NA	9.9e-07
5	GTEx	Skin Sun Exposed Lower leg	0.151	0.0470	0.00078	0.052	NA	0.083	NA	0.090	4.2e-05	NA	2.1e-07	NA	6.9e-08
6	GTEx	Thyroid	0.137	0.0470	0.00110	0.019	NA	0.018	NA	0.011	1.3e-02	NA	1.5e-02	NA	4.7e-02
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.057	0.0350	0.00930	-0.004	0.015	0.007	NA	-0.004	8.7e-01	2.9e-02	1.1e-01	NA	7.4e-01
8	TCGA	Rectum Adenocarcinoma	0.248	0.1010	0.00021	0.040	0.175	0.153	NA	0.151	4.1e-02	6.5e-05	2.0e-04	NA	2.2e-04
9	TCGA	Testicular Germ Cell Tumors	0.112	0.0630	0.00600	0.079	0.061	0.051	NA	0.071	9.6e-04	3.4e-03	6.7e-03	NA	1.7e-03
10	TCGA	Thyroid Carcinoma	0.044	0.0290	0.00690	0.008	0.013	0.023	NA	0.005	5.3e-02	1.7e-02	2.3e-03	NA	9.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.6	2.5	5.2	-0.9	-1.1	-2.2	-1.8	-1.6	-1.0	0.5	2.3	1.3	-2.0
Bipolar Disorder or Schizophrenia	0.7	1.7	3.6	-0.4	-0.4	-1.4	-1.7	0.1	-1.9	-1.0	1.9	0.8	-1.7
Depressed Affect (Nagel 2018)	0.6	1.2	2.3	-1.5	-0.9	-1.2	-1.0	-1.2	-0.2	0.5	1.4	1.2	-1.1
Depression (Nagel 2018)	0.9	1.3	2.4	-1.4	-1.0	-0.8	-1.0	-1.1	-1.0	1.0	1.4	1.6	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	-0.8	-0.1	0.9	0.6	-1.2	-1.3	1.4	-0.7	0.5	1.2
Neuroticism (Nagel 2018)	0.2	0.4	1.1	-1.0	0.1	-0.4	-0.3	-0.4	-0.6	0.1	0.8	1.0	-0.9
Schizophrenia (2018)	0.4	0.8	2.7	0.2	0.3	-0.1	-0.8	1.4	-1.5	-1.6	0.6	0.1	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.3	1.8	-0.5	-0.1	-0.1	-0.5	0.0	-1.3	-0.4	0.9	-0.2	-0.3
Worry (Nagel 2018)	0.2	0.4	1.5	0.0	0.8	-0.4	-0.0	0.3	-0.8	-0.7	0.5	0.1	-1.2
Alzheimer’s Disease (in mother)	1.1	1.3	4.8	-0.4	-0.5	-1.1	-1.2	-0.7	-1.4	-0.2	1.5	0.2	-2.2
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.6	0.3	0.4	0.3	-0.2	0.3	0.1	-0.1	-0.1	0.5
Alzheimer’s Disease (including proxy)	0.6	0.8	2.9	0.1	0.2	-0.6	-0.6	-0.4	-1.2	-1.0	1.2	-0.6	-1.7
Crohns Disease (2017)	0.8	1.7	3.5	1.5	1.6	1.4	1.9	-0.8	-0.2	-0.1	-1.8	-0.9	1.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	0.8	0.9	0.1	0.6	-0.5	-1.3	-0.7	0.1	-0.5	-0.5
Ulcerative Colitis (UC)	0.8	1.5	3.7	-0.2	-0.1	-1.4	-1.1	-0.2	-1.8	-1.3	1.6	-0.1	-1.9
Major Depression (MDD)	0.3	0.4	1.2	-0.4	-0.5	-0.0	-0.5	0.0	-0.6	0.9	1.1	0.4	-1.0
Reaction Time	0.5	0.9	1.8	1.1	0.9	-0.6	-0.5	-0.6	1.4	-1.3	0.1	-1.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.7	0.1	0.3	0.2	0.7	-0.7	-1.3	0.4	-1.3	-0.1	1.0
Breast Cancer	0.3	0.8	1.4	1.1	0.7	0.4	0.9	1.1	1.2	-0.6	-1.0	-1.0	0.3
Ovarian Cancer	0.7	0.9	4.1	-0.8	-0.9	0.5	0.2	-0.2	-1.0	2.0	0.2	1.3	0.5
Prostate Cancer	0.8	1.1	2.5	0.8	0.9	1.4	1.6	0.1	1.1	0.2	-1.3	-0.6	1.5
Age at First Birth	0.6	0.8	1.4	1.1	0.8	0.9	0.9	-1.0	1.2	-0.1	-0.9	-0.9	0.9
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.3	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	1.9	-0.2	-0.1	-0.3	-0.6	-0.2	0.2	-0.3	0.6	-0.2	-1.4
Coronary Artery Disease (CAD)	5.2	6.2	13.3	-2.1	-2.3	-3.4	-3.6	-1.3	-2.5	-0.1	2.9	1.8	-2.9
Crohns Disease (2012)	1.1	1.7	4.2	0.3	0.7	1.8	2.0	-0.3	-1.0	1.4	-1.4	-0.1	2.1
Mean Putamen Volume	0.8	0.9	2.1	-1.5	-1.1	0.1	-0.4	1.0	-0.8	1.1	1.0	1.3	-0.1
Fasting Glucose	0.2	0.2	1.0	-0.1	-0.1	-0.0	-0.1	-1.0	0.1	0.5	0.6	0.5	-0.6
HbA1C	1.5	1.7	4.0	1.2	0.7	1.1	1.7	2.0	1.9	-1.2	-1.1	-0.7	0.6
HDL Cholesterol	0.3	0.6	1.9	0.6	0.9	0.4	0.6	1.4	-0.1	-0.6	-0.7	-1.1	0.5
LDL Cholesterol	0.2	0.3	0.8	0.4	0.5	-0.0	0.7	-0.5	-0.7	-0.7	-0.6	-0.9	0.2
Lupus	1.6	2.4	8.7	-1.8	-1.5	-0.0	-0.8	-1.5	-0.8	3.0	0.9	2.3	0.3
Neuroticism (2016)	0.6	0.8	2.8	0.7	0.7	0.4	0.5	1.7	-0.6	-1.3	-0.9	-1.0	0.0
Primary Biliary Cirrhosis	0.4	0.5	1.5	-0.7	-0.6	0.4	-0.3	0.3	-1.2	0.3	1.1	1.2	-0.3
Rheumatoid Arthritis	0.3	0.4	1.2	0.1	0.1	-0.2	-0.3	0.6	-0.5	-1.0	0.7	-0.2	-1.1
Schizophrenia (2014)	0.8	1.8	3.8	-0.3	-0.1	-1.3	-1.8	0.5	-2.0	-1.4	1.8	0.5	-1.8
Triglycerides	0.6	0.9	4.1	0.6	0.4	-1.0	-0.7	-0.7	-0.4	-1.4	0.7	-0.4	-2.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	-0.5	-0.2	1.3	0.3	0.0	-0.1	1.4	0.0	1.1	0.8
Ulcerative Colitis	1.9	2.7	7.5	-1.4	-0.8	-1.0	-1.5	0.1	-2.4	-0.2	2.7	1.8	-2.1
Blood Eosinophil Count	0.3	2.4	8.8	0.0	0.2	3.0	1.8	1.7	1.1	0.7	-1.1	0.4	2.4
Blood Platelet Count	1.1	13.1	26.3	2.8	3.2	4.8	5.1	2.5	2.5	-0.1	-4.8	-2.7	4.5
Blood Red Count	0.3	3.1	8.0	-0.8	-0.2	2.3	1.4	-0.5	2.5	2.8	-0.4	1.9	2.3
Blood White Count	1.1	8.4	15.1	2.6	2.2	3.5	3.9	1.4	2.7	0.3	-3.9	-2.8	3.6
Heel T-Score	0.2	1.8	10.0	0.9	0.5	1.9	1.1	0.8	3.2	-0.1	-0.3	0.4	1.1
BMI	0.0	0.2	1.0	0.0	0.1	-0.2	-0.1	-1.0	-0.3	0.7	-0.7	-0.3	0.3
Height	0.4	7.7	21.6	-1.8	-1.9	-2.8	-2.8	-4.7	-2.1	3.1	2.6	2.8	-2.2
Waist Hip Ratio (WHR)	1.1	4.8	6.3	2.4	2.5	2.1	2.5	2.4	2.1	-1.9	-1.9	-2.4	1.6
Systolic Blood Pressure	1.2	5.8	9.0	2.1	2.6	2.8	2.8	3.0	1.5	-1.7	-2.7	-2.0	2.6
Smoking Status	0.1	0.1	0.5	-0.4	-0.4	-0.3	-0.6	0.3	-0.2	-0.0	0.7	0.3	-0.4
Allergy or Eczema	0.2	0.5	1.4	0.2	-0.5	0.5	0.3	-1.2	-0.3	1.2	-0.5	0.1	1.2
Cardiovascular Disease	0.2	0.6	4.2	-0.2	0.4	0.5	0.5	1.1	-2.1	-0.4	-0.1	-0.1	0.3
Hypothyroidism (self reported)	0.5	1.1	2.3	1.4	1.0	-0.0	0.5	1.3	-0.1	-1.5	-1.1	-1.4	-0.4
Respiratory disease	0.2	0.5	1.6	-1.2	-0.6	0.5	0.6	1.1	0.2	0.7	0.0	0.3	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.4	-0.5	-0.4	0.0	-0.4	-0.1	0.1	1.2	0.2	1.6	0.5
Lung FEV1/FVC ratio	0.1	0.5	1.3	0.8	0.7	-0.1	0.8	-0.7	1.2	-0.2	-1.1	-0.6	-0.2
Lung FVC	0.2	1.1	4.9	-0.7	-1.4	0.0	-0.4	-2.2	0.1	1.8	-0.2	0.4	0.7
Neuroticism	0.5	1.2	2.2	-1.5	-1.3	-1.0	-1.2	-0.6	-1.4	0.9	1.0	1.1	-0.6
Chronotype (morning person)	0.7	1.6	4.4	1.7	1.3	-0.4	0.1	0.5	0.9	-2.1	0.4	-1.6	-1.8
Hair Pigment	0.0	0.1	0.3	0.0	0.5	0.1	0.1	0.6	0.6	-0.2	0.4	-0.4	0.4
Tanning	0.1	1.1	2.6	-1.4	-1.4	0.2	-0.5	0.8	-1.3	0.9	1.1	1.6	-0.1
Hand grip strength (left)	0.9	2.3	6.0	1.6	1.6	1.3	1.7	-0.2	1.0	0.8	-2.4	-0.4	2.4
Number of treatments/medications taken	0.1	0.2	1.0	-0.1	0.5	0.3	0.2	1.0	-0.2	-0.7	0.4	-0.2	-0.6
Average weekly spirits intake	2.7	3.4	6.9	-2.3	-2.6	-1.1	-2.0	-1.7	-1.5	2.3	1.4	2.1	-0.0
Sensitivity / hurt feelings	0.5	0.8	1.7	-1.3	-0.8	-0.7	-0.9	0.3	-0.8	-0.3	1.3	0.9	-1.0
Frequency of depressed mood in last 2 weeks	1.9	2.6	5.1	-1.8	-1.7	-1.1	-1.6	-2.3	-1.0	2.0	1.5	1.9	-0.0
Hearing difficulty/problems: Yes	0.8	1.3	7.5	1.0	0.7	1.3	0.9	0.6	2.7	-0.1	-0.7	-0.2	0.5
Relative age of first facial hair	0.4	0.7	2.0	-1.4	-1.2	-0.4	-0.8	-0.2	-0.7	1.1	0.7	1.1	0.0
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	10.3	-0.8	-0.9	-2.0	-1.5	-0.1	-1.7	-0.8	2.0	0.2	-3.2
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.0	-1.1	-1.1	-1.3	-1.1	-0.5	-0.1	0.1	1.3	0.9	-1.7
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-0.9	-1.0	-0.6	-1.1	-0.4	-0.6	0.4	0.4	0.9	0.2
Systolic blood pressure, automated reading	0.6	1.6	3.7	0.9	1.2	1.3	1.1	1.3	0.9	-0.5	-1.9	-0.8	1.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.6	0.6	0.7	0.3	0.0	-0.1	0.6	-0.4	0.0	-0.2	-0.3
Angina	0.2	0.2	0.7	-0.4	-0.4	-0.8	-0.2	0.6	-0.0	-0.2	-0.4	-0.7	0.5
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.4	-0.5	0.7	0.4	0.5	-0.0	0.7	-0.1	0.4	0.2
Vitamin and mineral supplements	0.1	0.1	0.6	0.1	0.2	-0.4	-0.1	-0.0	-0.7	0.2	0.2	-0.0	-0.8
Supplements: Zinc	0.5	0.6	1.6	-0.8	-0.6	-0.8	-1.0	0.2	-0.5	-0.6	0.7	0.6	-1.3
Medication: Co-codamol	0.5	0.5	1.5	-0.4	-0.8	-1.2	-0.8	-1.0	-0.6	-0.2	0.3	-0.2	-1.0
Medication: Metformin	1.0	1.4	2.7	1.0	1.3	0.9	1.3	1.5	0.9	-0.3	-1.6	-0.8	1.5
Diabetes (father)	0.6	0.7	3.4	0.3	0.7	1.0	0.7	1.9	1.1	-0.3	0.2	0.1	0.5
Diabetes (mother)	2.1	2.7	6.1	1.7	1.8	0.3	1.3	1.9	1.5	-2.5	-1.6	-2.2	-0.1
Severe depression (siblings)	1.0	1.2	3.0	-1.4	-0.7	-0.1	-0.4	-1.1	-0.8	1.7	1.3	1.3	-0.8
Pack years adult smoking proportion	0.8	1.2	3.3	0.7	0.7	1.6	1.4	1.8	1.4	-1.0	-0.3	-0.7	0.2
Impedance of leg (right)	0.2	0.9	2.5	-0.7	-0.6	-0.2	-0.4	1.3	-0.5	-1.0	1.6	0.5	-1.6
Leg fat-free mass (left)	0.4	2.0	8.9	-0.3	-0.3	-1.3	-1.3	-3.0	-0.9	2.2	0.1	1.3	-0.0
Trunk fat percentage	0.1	0.4	1.2	0.6	0.7	-1.1	-0.4	-0.8	-0.2	-0.3	-0.1	-0.8	-0.7
Hand grip strength (right)	2.2	6.1	13.5	2.7	2.8	2.5	2.8	0.2	1.8	0.7	-3.7	-1.2	3.6
Townsend deprivation index at recruitment	2.2	3.0	6.8	-2.0	-2.0	-1.8	-2.6	-1.1	-2.2	0.9	2.1	1.0	-0.6
Current tobacco smoking	0.2	0.3	1.2	0.4	0.1	0.3	0.4	0.8	0.6	-0.0	-0.2	-0.5	1.1
Average weekly fortified wine intake	1.5	1.7	4.4	0.4	0.9	1.9	1.6	1.0	1.0	0.8	-1.7	0.0	2.1
Maternal smoking around birth	1.0	1.4	3.3	0.7	0.9	1.5	1.3	1.6	0.3	0.3	-1.3	-1.0	1.8
Fed-up feelings	1.0	1.7	4.9	-2.2	-1.8	-1.0	-1.2	-0.5	-0.6	1.4	1.5	1.4	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.4	6.8	-2.4	-2.3	-1.4	-1.7	-1.4	-1.2	1.2	2.6	2.0	-1.7
Relative age voice broke	0.8	1.2	3.7	-0.8	-1.2	-1.9	-1.7	-0.6	-1.4	-0.3	0.7	-0.1	-0.8
Taking other prescription medications	0.7	1.1	4.0	-1.2	-0.3	-1.1	-0.6	0.5	-0.6	-0.5	1.7	0.6	-2.0
Age when periods started (menarche)	1.2	2.8	10.6	-1.0	-1.4	-1.0	-1.1	-2.2	-3.2	1.6	1.3	0.9	-1.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	-0.6	-0.9	-0.2	-0.6	0.2	0.6	0.5	0.5	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	0.7	0.5	1.0	0.9	0.1	0.7	0.1	-0.3	-0.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	2.0	-0.1	0.3	0.5	0.4	1.4	0.5	-0.4	-0.3	0.4	0.0
Qualifications: CSEs or equivalent	0.5	0.6	2.4	-0.0	0.3	-0.2	-0.0	1.4	-1.5	-0.6	0.2	-0.1	-1.1
Serious illness, injury or assault to yourself	0.2	0.3	1.0	-0.5	-0.3	0.2	-0.0	0.4	-0.2	0.1	1.0	0.4	-1.0
High blood pressure	0.1	0.3	0.9	0.3	0.7	0.1	0.4	0.9	-0.3	-0.7	-0.5	-0.4	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.4	0.3	-0.4	1.0	0.7	-0.8	-0.1	1.4	-0.7	0.1	1.9
Multivitamins +/- minerals	1.9	2.4	4.8	1.2	1.2	2.0	1.9	0.8	2.2	-0.1	-1.8	-1.1	2.0
Stomach or abdominal pain in last month	1.1	1.4	3.8	1.2	1.4	1.2	1.3	-0.0	2.0	-0.0	-1.2	-1.1	1.1
Supplements: Glucosamine	1.2	1.6	4.1	1.1	1.3	0.8	1.4	0.1	2.0	-0.9	-1.7	-1.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.2	-0.0	-0.1	-1.5	-0.7	-0.9	-0.7	-0.6	0.4	-1.1	-0.6
Medication: Atenolol	0.4	0.5	1.8	0.4	0.6	-0.0	0.1	1.3	-0.2	-1.4	0.1	-0.7	-0.2
Medication: Levothyroxine sodium	0.4	0.7	1.3	1.1	1.1	0.2	0.7	0.9	-0.0	-1.0	-0.7	-1.0	-0.4
Sitting height	0.7	4.8	16.5	-1.5	-1.7	-0.5	-1.2	-3.7	0.1	4.1	1.0	3.1	0.3
Chronic bronchitis/emphysema (father)	0.2	0.3	1.3	-0.3	-0.4	-0.2	-0.2	0.8	-1.2	-0.3	0.3	-0.4	-0.2
High blood pressure (mother)	1.0	1.4	4.8	-1.5	-1.2	-0.0	-1.1	-0.2	-2.2	1.1	1.0	1.5	0.1
Body mass index (BMI)	0.1	0.4	1.1	-0.1	0.2	-0.8	-0.7	-1.1	-0.8	0.9	-0.3	0.3	0.3
Impedance of leg (left)	0.1	0.6	2.0	-0.2	-0.3	0.3	0.2	1.4	0.3	-1.2	0.9	-0.1	-1.0
Leg predicted mass (left)	0.4	2.1	9.4	-0.3	-0.4	-1.3	-1.3	-3.1	-0.9	2.3	0.1	1.4	0.1
Trunk fat mass	0.1	0.5	2.6	0.5	0.6	-1.0	-0.6	-1.6	-0.1	0.6	-0.3	-0.2	-0.2
Waist circumference	0.2	0.7	2.1	1.3	1.5	-0.1	0.4	-0.8	0.6	0.0	-1.0	-1.0	0.5
Number of incorrect matches in round	0.4	0.7	1.8	-0.7	-0.3	-0.8	-0.4	1.0	0.5	-0.9	1.3	0.2	-1.2
Past tobacco smoking	0.2	0.4	1.0	0.4	0.4	1.0	0.8	-0.1	0.6	0.4	-0.5	-0.2	0.9
Alcohol usually taken with meals	0.2	0.2	0.6	0.6	0.6	0.3	0.7	-0.1	-0.3	-0.7	-0.0	-0.2	-0.7
Nervous feelings	0.1	0.2	0.6	0.3	0.7	-0.1	0.0	0.4	-0.8	-0.5	0.2	0.2	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.3	-1.8	-1.2	-0.7	-0.9	-1.0	-0.5	0.8	1.6	1.0	-0.8
Hearing difficulty/problems with background noise	0.2	0.4	2.4	0.5	0.4	-0.3	0.1	-0.8	1.6	0.3	-0.1	0.2	0.1
Hair/balding pattern: Pattern 2	0.8	1.0	2.5	1.6	1.6	0.1	0.7	0.1	0.2	-1.2	-0.8	-1.5	0.1
Had menopause	0.9	1.2	2.6	-1.0	-1.2	-1.6	-1.4	-1.2	-0.4	-0.3	1.1	0.2	-1.4
Had other major operations	0.4	0.5	1.4	-1.2	-1.0	0.0	-0.5	0.3	-0.9	0.7	0.6	1.0	-0.0
Forced vital capacity (FVC)	0.9	3.4	9.4	-1.9	-2.1	-0.5	-1.0	-2.8	-0.7	3.1	1.0	2.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	1.0	1.0	1.1	1.1	1.0	1.1	-0.6	-0.2	-0.2	0.4
Ever unenthusiastic/disinterested for a whole week	4.0	4.9	9.2	-2.6	-3.0	-1.9	-2.5	-2.1	-1.7	2.3	2.1	2.3	-0.7
Qualifications: None of the above	1.5	3.3	5.5	-2.3	-2.3	-2.1	-2.3	-0.9	-1.5	0.8	2.2	1.4	-1.3
Financial difficulties in last 2 years	1.0	1.3	3.6	-1.2	-1.4	-0.6	-0.8	-1.5	-1.1	1.9	0.7	0.7	0.4
Mouth/teeth dental problems	0.8	1.2	6.1	-0.2	-0.1	-1.5	-1.3	-0.2	-0.2	-0.3	1.2	0.6	-2.5
Heart attack	1.1	1.4	3.9	-1.1	-1.3	-2.0	-1.6	-1.0	-0.2	0.8	1.3	0.7	-0.6
Allergy	0.3	0.8	2.9	0.4	0.6	-0.7	-0.5	0.8	0.0	-1.7	-0.0	-0.6	-1.6
Pain all over the body in last month	0.3	0.4	1.1	-0.8	-0.4	0.1	-0.1	1.0	-0.9	0.0	0.7	0.5	-0.5
Diabetes (self-reported)	0.0	0.1	0.2	0.1	0.3	-0.4	-0.2	-0.2	0.2	0.0	-0.1	0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	0.3	-0.0	-0.0	-0.0	0.4	0.6	-0.0	-0.0	-0.3	-0.0
Medication: Ramipril	0.4	0.5	1.6	0.9	0.8	-0.6	0.4	-1.2	0.8	-0.1	-0.7	-0.8	0.1
Medication: Simvastatin	0.1	0.2	0.5	0.3	0.7	-0.1	-0.2	-0.7	-0.0	0.5	0.2	0.6	-0.2
Fluid intelligence score	0.3	0.6	2.3	-0.4	-0.3	0.3	0.2	-1.0	-0.9	1.1	-0.8	0.4	1.5
Illnesses of siblings	0.1	0.2	0.5	-0.2	-0.7	-0.4	-0.2	-0.0	-0.6	-0.4	0.4	0.0	-0.7
Neuroticism score	0.4	0.9	1.9	-1.4	-1.1	-0.5	-0.7	-0.8	-0.9	1.0	1.0	1.1	-0.3
Weight	0.3	1.5	7.2	-0.2	-0.1	-1.3	-1.2	-2.7	-0.6	1.9	0.1	1.0	0.1
Impedance of arm (right)	0.6	2.8	11.4	1.2	1.2	-0.6	0.4	1.8	0.8	-3.4	0.3	-2.2	-2.0
Arm fat percentage (right)	0.1	0.5	1.2	0.8	1.1	-1.1	-0.3	-0.5	-0.2	-0.7	-0.6	-1.0	-0.2
Trunk fat-free mass	0.6	3.3	12.8	-0.7	-0.8	-1.0	-1.4	-3.6	-0.5	3.2	0.3	2.3	0.7
Hip circumference	0.2	0.7	3.9	0.2	0.3	-0.9	-0.6	-2.0	-0.3	1.2	-0.4	0.1	0.1
Time employed in main current job	0.1	0.1	0.4	0.3	0.2	-0.4	-0.1	0.3	-0.2	-0.6	0.2	0.0	-0.4
Alcohol intake versus 10 years previously	0.8	1.1	4.1	-0.3	-0.8	-1.3	-1.3	0.5	-0.4	-0.7	1.4	-0.2	-2.0
Father’s age at death	0.1	0.2	0.5	-0.2	-0.2	-0.7	-0.5	-0.3	0.6	-0.1	0.4	-0.1	-0.6
Worrier / anxious feelings	0.4	0.8	2.6	-1.4	-0.6	0.4	0.1	-0.1	-0.6	1.6	0.3	1.4	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	5.6	-2.4	-1.9	-0.6	-1.1	-0.5	-2.1	1.7	1.9	2.1	-0.6
Falls in the last year	0.1	0.2	0.5	-0.5	-0.1	0.3	-0.1	0.3	0.2	0.3	0.7	0.7	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.2	-0.5	0.9	0.3	0.8	0.1	0.7	0.1	0.4	0.5
Number of live births	1.8	2.6	7.3	-0.9	-0.8	-1.2	-1.4	-2.7	-0.6	2.0	1.7	2.0	-1.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	8.7	-1.8	-1.8	-0.5	-0.9	-2.7	-0.6	2.9	0.7	2.3	0.3
Pulse rate	0.5	0.8	2.3	0.4	1.1	1.0	1.4	1.5	0.4	-0.1	-0.6	-0.3	0.6
Happiness	0.4	0.4	1.2	-0.4	-0.7	-0.8	-0.4	-1.1	0.7	0.6	0.2	-0.7	-0.5
Noisy workplace	0.5	0.6	1.4	1.0	0.5	0.2	0.3	0.4	1.0	-0.7	-1.0	-1.2	0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.3	3.6	1.9	1.8	1.4	1.9	1.0	1.1	-1.0	-1.8	-1.5	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	0.4	0.5	0.9	1.0	1.3	0.2	-0.1	-0.4	-0.5	0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	0.3	0.3	0.2	0.4	1.0	0.1	-0.3	-0.9	-1.1	1.3
Asthma	0.2	0.4	0.9	-0.9	-0.6	0.9	0.3	0.5	0.2	0.7	0.5	0.7	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	1.5	1.0	0.9	0.4	0.3	-0.7	1.2	-0.4	0.2	-0.4	-0.4
Medication: Cholesterol lowering	0.8	1.2	2.9	-0.7	-0.0	-0.6	-1.0	-1.7	-1.6	1.2	1.1	1.4	-0.6
Depression (self-reported)	2.8	3.3	11.1	-1.9	-1.5	-1.2	-1.2	-3.3	-0.9	1.7	2.1	2.0	-1.1
Medication: Lansoprazole	0.6	0.7	1.6	-0.8	-0.8	-0.2	-0.9	-1.0	-0.3	1.2	0.3	1.3	0.5
Prospective memory result	0.5	0.6	1.7	0.4	0.8	0.4	0.0	1.3	-0.3	-1.3	0.5	-0.1	-1.1
Lung cancer (father)	1.0	1.1	2.1	-1.3	-1.1	-1.4	-1.3	0.2	-1.3	-0.3	1.2	0.9	-0.9
Illnesses of mother	0.8	1.0	2.6	0.5	0.3	1.5	1.5	0.3	0.9	0.7	-0.9	-0.0	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	10.4	-1.6	-2.0	-1.1	-1.3	-3.2	-0.4	2.3	0.8	1.7	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.7	-0.2	0.0	-0.1	0.7	0.4	0.1	0.5	0.7	0.0
Impedance of arm (left)	0.5	2.3	8.6	1.0	0.9	-0.4	0.5	1.9	0.7	-2.9	0.3	-2.0	-1.8
Arm fat mass (right)	0.2	0.7	3.4	0.2	0.5	-1.3	-0.8	-1.8	-0.5	0.7	-0.3	0.0	0.0
Trunk predicted mass	0.6	3.3	13.0	-0.8	-0.8	-1.0	-1.4	-3.6	-0.5	3.2	0.3	2.2	0.7
Standing height	0.3	3.2	15.4	-0.5	-0.8	-1.4	-1.4	-3.9	0.2	2.6	0.9	1.9	-0.5
Length of working week for main job	1.1	1.2	2.8	-0.6	-0.3	1.5	0.8	0.9	0.1	1.7	-0.4	1.5	1.6
Exposure to tobacco smoke at home	2.7	3.1	6.7	2.6	2.1	0.9	1.9	0.5	2.1	-1.8	-1.4	-2.3	0.7
Breastfed as a baby	1.9	2.4	7.8	2.3	1.4	-0.8	0.7	-0.7	0.9	-2.0	-1.1	-2.8	-1.0
Tense / ‘highly strung’	0.4	0.7	2.2	-0.7	-0.6	-0.6	-0.8	-0.2	-1.5	0.1	1.1	0.3	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	6.3	-2.1	-1.6	-1.4	-2.1	-0.7	-2.0	0.9	2.5	2.0	-1.6
Hair/balding pattern: Pattern 4	0.4	0.9	1.5	-1.0	-0.8	-1.2	-1.2	-0.9	0.5	-0.2	1.2	1.0	-0.9
Birth weight of first child	0.6	1.0	2.6	-0.9	-1.1	-0.1	-1.3	-1.0	0.9	0.9	1.6	0.9	-0.7
Peak expiratory flow (PEF)	0.9	2.1	6.3	-1.7	-1.1	0.0	-0.4	-2.1	0.3	2.5	0.4	2.2	0.1
Pulse wave reflection index	0.3	0.3	0.9	-0.4	-0.4	-0.6	-0.5	-0.6	-0.4	-0.3	0.8	0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.4	-1.2	-1.6	-1.0	-0.8	-1.4	-1.1	0.9	0.7	0.4	-0.4
Loud music exposure frequency	0.8	0.9	1.6	-0.7	-1.3	-0.9	-1.2	-1.2	-1.2	0.5	0.7	0.4	-0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.0	1.5	1.1	1.8	1.9	-0.6	1.2	1.0	-2.0	-0.8	1.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	-0.9	-0.9	-0.8	-1.2	-0.6	-0.9	-0.3	1.3	0.9	-0.9
Blood clot in the leg (DVT)	1.1	1.4	3.9	-1.4	-1.4	-0.6	-0.9	-1.1	-0.4	2.0	1.1	1.5	0.0
Medication: Paracetamol	0.2	0.4	1.1	-0.4	-0.4	0.7	0.2	-1.0	0.1	1.0	-0.2	0.3	1.0
Headache pain in last month	0.7	1.2	4.1	-1.4	-1.3	1.1	0.2	0.3	0.3	2.0	0.3	1.1	1.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.5	1.2	0.7	0.3	1.0	0.8	1.6	-1.0	-1.6	-1.5	0.5
Glaucoma (self-reported)	0.3	0.4	1.0	0.7	0.6	0.4	0.4	0.8	0.5	-1.0	-0.3	-0.6	0.2
Gout (self-reported)	0.2	0.3	0.9	-0.2	0.2	1.0	0.7	0.6	0.4	0.8	-0.0	0.4	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	0.5	0.3	-0.2	0.1	0.9	-0.7	-1.0	-0.5	-0.7	-0.6
Medication: Amlodipine	1.5	2.1	7.2	0.7	0.9	2.7	1.8	2.0	0.6	-0.0	-1.0	0.0	2.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.4	-0.7	-0.0	0.8	0.2	1.5	0.6	-0.0	0.9	0.7	0.5
Birth weight	1.3	2.8	7.0	-1.4	-1.3	-1.8	-2.5	0.3	-0.8	-0.1	2.6	1.3	-2.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-0.2	-0.2	-1.1	-0.9	1.1	-1.0	-0.9	1.0	-0.3	-1.5
High blood pressure (siblings)	0.7	1.0	2.7	0.6	1.1	1.6	0.9	0.3	1.3	0.8	-0.7	-0.1	1.5
Forced vital capacity (FVC), Best measure	0.8	3.0	12.0	-1.4	-1.9	-0.9	-1.1	-3.5	-0.5	2.5	0.8	1.6	0.0
Body fat percentage	0.1	0.3	0.9	0.5	0.7	-0.9	-0.3	-0.7	-0.4	-0.1	-0.2	-0.6	-0.4
Leg fat percentage (right)	0.1	0.2	1.0	0.1	0.3	-1.0	-0.8	-0.2	-0.6	-0.2	-0.1	0.1	-0.3
Arm fat-free mass (right)	0.7	3.5	12.7	-1.0	-1.0	-0.7	-1.3	-3.6	-0.7	3.5	0.3	2.4	0.7
Exposure to tobacco smoke outside home	0.5	0.7	2.3	0.6	0.7	1.5	1.0	-0.7	0.3	0.5	-0.8	0.2	1.1
Comparative body size at age 10	0.0	0.1	0.8	-0.4	0.2	-0.1	-0.3	0.2	0.3	-0.0	0.3	0.9	0.0
Number of full brothers	0.3	0.3	1.7	-0.6	-0.3	-0.5	-0.1	-1.3	-0.1	0.9	0.1	0.4	-0.1
Worry too long after embarrassment	0.2	0.4	1.0	-0.3	0.4	0.9	0.6	-1.0	0.3	0.4	-0.6	0.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	6.2	-2.0	-1.9	-1.4	-1.5	-1.3	-2.5	1.3	1.8	1.6	-1.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.0	-0.8	-0.3	0.9	0.4	1.2	0.6	1.0	0.1	0.8	1.4
Number of children fathered	0.5	0.5	1.7	-0.4	-0.6	0.2	-0.2	-1.1	0.5	1.3	-0.5	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.7	-0.2	0.2	-2.2	-1.5	-0.9	0.2	-1.6	1.2	-0.1	-2.2
Age at first live birth	0.6	1.0	3.1	1.0	1.4	1.0	1.3	0.3	1.8	-0.7	-0.1	-0.5	-0.1
Pulse wave peak to peak time	0.2	0.2	1.2	0.7	0.1	-0.3	-0.1	-1.1	-0.4	-0.0	-0.4	-0.6	-0.1
Health satisfaction	2.1	2.8	4.6	-2.1	-2.1	-1.7	-2.1	-1.3	-0.7	1.7	1.6	1.8	-0.3
Shortness of breath walking on level ground	2.9	3.5	6.9	-2.2	-1.8	-1.9	-2.3	0.0	-2.3	0.5	2.6	1.6	-1.6
Qualifications: College or University degree	0.9	2.9	5.9	1.7	1.8	2.2	2.4	-0.2	1.0	-0.4	-2.2	-1.2	2.0
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.4	0.9	0.1	0.7	-0.7	0.8	0.1	-0.7	-0.5	0.1
Mouth/teeth dental problems: Loose teeth	1.3	1.6	5.1	-0.2	-0.2	1.8	1.5	-0.4	0.7	1.9	-0.8	0.4	2.2
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.5	-0.1	-0.2	-0.2	0.7	-0.4	-0.0	0.2	0.7	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	1.4	0.1	0.1	0.1	0.3	1.2	-0.3	-0.2	-0.2	0.1	0.2
Neck or shoulder pain in last month	0.7	0.9	2.6	0.3	0.8	1.1	1.5	1.6	0.0	-0.5	-1.0	-0.9	0.9
Medication: Blood pressure	0.1	0.1	0.4	0.1	0.4	-0.3	-0.3	0.1	-0.6	-0.5	0.4	-0.3	-0.0
Angina (self-reported)	0.2	0.2	0.7	-0.6	-0.6	-0.8	-0.4	0.6	0.1	-0.0	-0.3	-0.4	0.4
Migraine (self-reported)	0.5	0.6	1.6	-0.8	-0.5	0.5	-0.1	0.5	-1.3	1.2	0.4	1.1	-0.1
Medication: Ibuprofen	0.9	1.1	2.5	1.6	1.5	0.7	0.7	-0.1	1.6	-1.0	-0.6	-1.1	-0.0
Medication: Allopurinol	0.4	0.5	1.9	-0.5	0.0	1.1	0.7	0.2	0.3	1.4	-0.1	0.6	0.6
Medication: Omeprazole	0.3	0.4	1.4	0.5	1.2	-0.7	-0.2	0.2	-0.2	-0.9	-0.1	-0.8	-0.6
Medication: Seretide 50 evohaler	2.7	3.1	7.5	-2.5	-2.0	0.6	-0.5	0.7	-2.1	2.3	1.7	2.7	0.2
Mean time to correctly identify matches	0.8	1.6	4.0	1.3	1.2	-0.6	-0.2	-1.0	2.0	-1.9	-0.3	-1.6	-1.0
Heart disease (mother)	0.1	0.1	0.4	0.2	0.5	-0.5	0.1	-0.3	0.4	-0.3	-0.4	-0.6	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.4	-0.2	-0.3	-0.2	0.8	0.6	-0.6	-0.3	-0.3	0.4
Whole body fat mass	0.2	0.6	3.3	0.2	0.4	-1.1	-0.7	-1.8	-0.4	0.9	-0.1	0.1	-0.1
Leg fat mass (right)	0.2	0.8	2.2	-0.3	-0.1	-1.3	-1.2	-1.5	-0.9	0.9	0.2	0.8	-0.4
Arm predicted mass (right)	0.7	3.3	11.9	-1.0	-1.0	-0.5	-1.1	-3.3	-0.6	3.4	0.3	2.5	0.6
Pulse rate, automated reading	0.2	0.7	1.7	-0.5	0.5	0.7	0.9	0.2	-1.0	1.3	-0.4	0.9	1.0
Alcohol intake frequency.	0.1	0.2	0.8	-0.3	-0.0	0.2	-0.1	0.4	0.1	0.4	0.4	0.4	-0.9
Comparative height size at age 10	0.2	1.2	4.1	1.1	0.6	-1.3	-0.6	-2.0	1.1	-0.5	0.3	-0.5	-1.3
Number of full sisters	0.6	0.8	1.4	-0.9	-1.2	-1.1	-0.9	-0.4	-1.0	0.7	0.8	0.7	-0.8
Suffer from ‘nerves’	0.2	0.3	0.8	-0.5	0.0	-0.5	-0.9	-0.6	-0.3	0.3	0.7	0.8	-0.5
Overall health rating	0.7	1.5	3.3	-1.8	-1.4	-0.8	-1.1	-0.9	-1.1	1.8	1.0	1.4	-0.1
Chest pain or discomfort	1.7	2.5	6.7	-1.0	-0.0	2.6	1.6	2.4	0.5	1.3	-0.5	0.7	2.4
Had major operations	0.3	0.3	1.2	-0.2	-0.3	-0.8	-0.2	0.4	0.4	-1.1	0.3	-0.5	-0.9
Age at last live birth	0.4	0.5	1.6	0.7	1.3	0.7	0.7	-0.4	1.3	0.0	0.3	-0.3	-0.5
Family relationship satisfaction	0.8	1.0	7.3	-0.3	-0.7	-0.5	-0.4	-2.7	0.2	1.3	-0.1	-0.3	0.6
Leg pain on walking	0.4	0.5	3.2	-0.1	-0.0	-0.6	-0.6	-1.8	-0.1	0.9	-0.1	0.4	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	2.6	1.4	1.6	1.1	1.3	1.3	1.6	-0.9	-1.3	-1.3	0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.0	-0.1	0.2	0.1	0.3	1.4	-0.7	-0.3	0.2	0.0	-1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	0.7	0.9	0.2	0.4	-0.3	1.2	-0.3	-1.4	-0.4	0.9
Medication: Aspirin	0.3	0.4	1.3	-0.1	0.1	-0.7	-0.7	0.3	0.1	-1.1	0.3	-0.6	-1.0
Supplements: Vitamin C	0.1	0.1	0.3	-0.2	-0.1	-0.2	-0.4	0.5	0.1	-0.4	0.4	0.5	0.1
Knee pain experienced in last month	0.3	0.5	1.6	-0.6	-0.8	0.2	-0.3	-0.9	0.1	1.2	-0.2	0.1	1.3
Hypertension (Self-reported)	0.4	1.2	2.1	1.1	1.4	0.5	1.0	1.4	0.2	-1.3	-1.1	-1.0	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.0	-0.2	0.1	0.3	0.3	0.3	-0.2	-0.3	-0.5	0.2
Illnesses of father: Heart disease	1.2	1.7	4.4	0.9	1.1	2.1	1.8	1.4	1.5	0.1	-1.2	-0.4	1.4
Illnesses of siblings: Diabetes	2.9	3.6	7.8	2.3	2.4	1.1	1.9	0.8	1.8	-1.3	-2.8	-2.3	1.3
Smoking status: Previous	1.1	1.6	2.8	-1.4	-1.2	-1.7	-1.5	-0.9	-1.5	0.3	1.2	0.9	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	6.1	-1.3	-1.3	0.0	-0.4	-1.2	-2.0	2.5	0.6	2.1	-0.1
Whole body fat-free mass	0.5	2.8	12.0	-0.5	-0.6	-1.0	-1.2	-3.5	-0.5	2.9	0.1	1.9	0.5
Leg fat-free mass (right)	0.3	1.7	9.1	0.1	-0.1	-1.0	-1.0	-3.0	-0.4	2.1	-0.3	0.9	0.5
Arm fat percentage (left)	0.1	0.4	1.0	0.8	1.0	-0.8	-0.2	-0.2	-0.1	-0.5	-0.7	-1.0	-0.1
Average weekly red wine intake	1.6	2.4	5.1	2.1	1.7	1.0	1.5	-0.4	2.3	-1.4	-1.6	-1.8	0.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.4	-0.6	-0.4	-0.8	-0.9	1.4	-0.2	-1.0	1.5	0.7	-1.5
Mood swings	0.1	0.2	0.5	-0.7	-0.6	-0.1	-0.3	0.0	-0.0	0.5	0.3	0.4	0.5
Loneliness, isolation	4.4	6.1	11.3	-2.7	-2.9	-2.7	-2.8	-3.4	-1.9	1.8	2.5	1.9	-1.6
Long-standing illness, disability or infirmity	0.9	1.4	4.5	-1.2	-0.5	-0.6	-0.9	1.1	-0.5	-0.8	2.0	0.5	-2.1
Ever had bowel cancer screening	1.3	1.5	3.5	1.7	1.6	0.4	0.9	-0.3	1.9	-1.1	-1.1	-1.6	0.0
Diabetes diagnosed by doctor	0.1	0.2	0.9	-0.2	-0.1	-0.4	-0.4	-0.3	0.4	0.5	0.0	0.9	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.6	-1.1	-0.9	-0.0	-0.6	-1.3	-1.0	1.6	0.7	1.5	-0.2
Friendships satisfaction	1.0	1.2	4.1	-0.6	-0.5	1.0	0.6	-1.3	0.0	2.0	-0.4	0.5	1.9
Qualifications: nursing, teaching	0.0	0.1	0.3	0.3	-0.1	-0.0	-0.2	0.3	-0.0	-0.5	0.2	-0.3	0.0
Commuting to job workplace: Walk	0.4	0.4	0.9	0.7	1.0	0.6	0.7	-0.6	0.2	-0.4	-0.7	-0.8	0.2
Eye problems/disorders: Cataract	0.8	0.9	2.2	-1.1	-1.5	-0.6	-1.3	-0.2	-0.4	0.5	1.0	1.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.2	-0.0	0.1	1.6	1.1	-0.0	0.3	1.3	-0.6	0.0	1.8
Medication for cholesterol	0.3	0.4	1.8	-0.8	-0.4	-0.2	-0.5	0.2	-0.6	-0.4	1.3	0.3	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	0.4	-0.0	-0.1	-0.1	-0.5	-0.6	0.1	-0.3	-1.0	-0.2
Back pain experienced in last month	0.6	0.8	2.6	-0.3	-0.4	-1.4	-0.9	-0.3	-1.6	-0.5	0.6	-0.9	-1.1
Mineral and other dietary supplements	0.1	0.2	0.4	0.3	0.6	0.7	0.6	0.2	-0.2	0.5	0.2	0.2	0.5
Breast cancer (self-reported)	0.7	0.8	3.4	0.6	0.0	0.7	0.6	1.9	0.6	-1.3	-0.5	-0.9	-0.1
Asthma (self-reported)	0.1	0.3	0.6	-0.7	-0.5	0.8	0.4	0.5	0.3	0.6	0.3	0.4	0.6
Osteoporosis (self-reported)	0.1	0.2	0.6	-0.2	-0.1	-0.0	0.2	0.2	-0.8	-0.3	0.5	0.2	-0.7
Osteoarthritis (self-reported)	5.0	6.5	11.4	-2.7	-2.7	-2.9	-3.1	-0.7	-2.8	-0.1	3.1	1.6	-3.4
Medication: Aspirin	0.2	0.3	0.8	-0.1	-0.0	-0.7	-0.7	-0.3	0.1	-0.7	0.3	-0.4	-0.9
Medication: Gliclazide	0.5	0.5	1.9	0.1	0.0	-1.2	-1.2	-1.4	0.3	0.4	-0.2	0.2	-0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-0.2	-0.0	-1.4	-0.6	-1.4	0.0	-0.4	0.3	0.3	-1.0
Smoking status: Current	0.2	0.4	1.1	0.6	0.3	0.5	0.6	0.7	0.8	0.1	-0.3	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.1	-1.6	-1.7	-0.5	-0.8	-1.6	-1.0	2.0	0.7	1.3	-0.3
Whole body water mass	0.5	3.1	12.5	-0.7	-0.7	-1.1	-1.4	-3.5	-0.7	3.0	0.2	2.0	0.6
Leg predicted mass (right)	0.3	1.5	8.8	0.1	-0.0	-1.0	-0.9	-3.0	-0.4	1.9	-0.3	0.8	0.4
Arm fat mass (left)	0.1	0.5	2.6	0.1	0.3	-1.1	-0.8	-1.6	-0.5	0.8	-0.2	0.2	-0.0
Number of self-reported non-cancer illnesses	0.4	0.7	2.6	-1.3	-0.4	0.4	0.1	1.6	-0.5	-0.1	1.2	0.8	-0.4
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-0.0	0.4	-0.3	0.0	-0.9	-1.2	0.7	-0.4	0.2	0.8
Miserableness	0.9	1.6	2.6	-1.3	-1.1	-1.6	-1.5	-1.0	-1.1	-0.1	1.6	1.3	-1.2
Guilty feelings	0.2	0.4	1.1	-1.0	-0.5	0.5	-0.3	0.4	-0.8	0.3	0.8	0.7	0.1
Wears glasses or contact lenses	0.7	0.8	4.3	-0.3	-0.4	0.2	0.1	0.2	0.9	0.7	-1.2	-0.5	2.1
Ever taken oral contraceptive pill	0.8	0.8	2.0	-1.3	-0.8	0.0	-0.3	-0.6	-0.5	1.4	1.4	1.3	-0.1
Hearing aid user	1.9	2.1	5.0	1.2	1.4	2.2	2.0	0.9	1.8	0.2	-1.5	-0.7	1.6
Mother’s age at death	0.4	0.5	2.5	0.2	0.1	-0.1	0.3	-1.6	1.2	0.7	0.2	0.5	-0.0
Financial situation satisfaction	0.3	0.3	1.3	-0.5	-0.3	-0.6	-0.4	-1.1	-0.2	0.8	0.6	0.3	0.1
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.4	1.7	1.7	0.6	1.8	0.5	1.4	-1.7	-1.4	-2.1	-0.4
Commuting to job workplace: Public transport	0.5	0.5	1.6	-0.4	-0.7	-1.1	-0.8	-1.3	0.3	0.4	-0.2	-0.2	1.0
Eye problems/disorders: Glaucoma	0.7	0.9	4.2	0.6	0.3	-0.3	-0.5	1.7	0.2	-2.1	0.4	-0.7	-0.3
Medication: Blood pressure	0.3	0.5	1.3	0.7	0.8	0.3	0.8	0.2	0.7	-0.2	-1.1	-0.4	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.7	-1.2	-1.3	-0.4	-1.1	-0.6	-0.8	0.9	0.9	1.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.4	-1.0	-1.2	-0.4	-0.6	-1.4	0.1	1.5	-0.2	0.8	0.8
High cholesterol (Self-reported)	0.4	0.7	3.2	-0.7	-0.3	-0.5	-0.7	-0.4	-1.8	0.3	0.8	0.5	-0.9
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.2	0.4	0.6	0.4	0.0	-0.7	-0.0	-0.1	0.3	0.4
Medication: Paracetamol	0.2	0.3	1.8	-0.2	0.1	1.3	0.5	-0.1	0.6	0.5	-0.0	0.1	0.6
Medication: Lisinopril	1.5	2.0	3.9	1.9	2.0	0.2	0.7	1.3	1.1	-1.9	-1.4	-1.8	0.1
Medication: Atorvastatin	0.4	0.4	1.8	0.1	0.2	-0.9	-0.4	-0.2	-1.3	-0.7	-0.0	-0.9	-0.4
Illnesses of father: High blood pressure	0.5	0.6	3.1	-0.3	-0.5	1.0	-0.1	-0.4	-0.9	1.8	0.0	0.5	0.7
Alcohol drinker status: Never	0.2	0.2	1.3	-0.3	0.2	0.6	0.3	1.1	-0.3	-0.1	-0.6	0.2	0.3
Ever smoked	0.1	0.2	0.6	-0.3	-0.5	-0.6	-0.6	0.8	0.5	-0.4	0.2	0.4	-0.3
Basal metabolic rate	0.5	2.8	11.9	-0.6	-0.5	-1.3	-1.4	-3.5	-0.7	2.8	0.2	1.8	0.4
Leg fat percentage (left)	0.0	0.2	0.4	0.5	0.5	-0.7	-0.4	0.0	-0.1	-0.5	-0.5	-0.4	0.1
Arm fat-free mass (left)	0.7	3.4	13.6	-0.9	-0.9	-1.0	-1.4	-3.7	-0.5	3.2	0.3	2.2	0.7
Number of operations (self-reported)	0.2	0.3	1.3	-1.0	-1.1	-0.6	-0.4	0.2	-0.5	0.2	0.1	0.3	-0.0
Average weekly beer plus cider intake	0.5	0.7	2.6	0.6	0.9	0.8	0.7	1.6	0.5	-0.8	-1.0	-0.3	0.5
Irritability	0.6	1.0	3.3	-1.4	-1.0	0.3	-0.8	-0.4	-0.4	1.5	0.8	1.8	0.1
Risk taking	0.3	0.4	1.9	-0.0	-0.4	0.4	0.7	-1.4	-0.6	0.9	-0.3	0.3	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	0.1	0.1	-0.1	-0.3	0.4	-0.4	-0.6	-0.0	0.1	-1.0
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.8	-0.8	0.9	0.3	0.6	-0.5	0.9	0.1	0.4	0.5
Age started oral contraceptive pill	0.6	0.7	1.1	-0.9	-1.0	-0.9	-0.7	-1.1	-0.4	0.3	1.0	0.8	-1.0
Diastolic blood pressure, automated reading	0.4	1.2	5.3	-0.7	-0.3	1.0	0.6	0.3	-0.4	1.4	-0.8	1.3	2.3
Ever depressed for a whole week	1.9	2.4	6.2	-1.5	-1.9	-1.2	-1.4	-2.5	-0.8	2.1	0.8	1.6	0.1
Unable to work because of sickness or disability	0.5	0.7	2.7	-0.7	-0.6	-0.3	-0.3	0.1	-0.8	0.3	1.6	0.3	-1.4
Commuting to job workplace: Cycle	1.3	1.6	6.2	1.7	1.5	-0.4	0.1	-0.1	0.5	-2.5	-0.2	-1.7	-1.2
Myopia	0.4	0.6	1.6	0.3	0.4	1.0	1.2	0.1	1.3	0.7	-0.4	0.3	1.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.0	-0.4	0.1	-0.2	-0.5	0.3	0.3	0.1	0.1	-0.6
Cholesterol lowering medication	0.6	0.8	1.4	1.2	0.9	0.5	0.8	1.2	0.9	-0.8	-0.9	-1.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.1	-0.3	0.2	-1.0	-0.7	-0.5	-0.6	0.1	0.6	0.2	-0.7
Pain experienced in last month	0.3	0.5	1.6	1.0	1.1	-0.2	0.2	0.0	0.6	-1.3	0.1	-0.3	-1.0
Supplements: Calcium	0.5	0.5	1.6	-0.7	-0.7	-0.2	-0.4	1.2	-1.3	-0.4	0.5	0.5	-0.6
Basal cell carcinoma (self-reported)	1.2	1.4	3.2	0.2	0.2	1.7	1.7	0.8	1.7	0.3	-1.0	-0.3	1.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.7	-0.9	-1.1	-1.6	-1.4	-0.8	0.1	0.7	1.1	0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	3.0	-1.2	-1.1	-0.4	-0.6	-1.1	-0.2	1.7	0.9	1.2	0.0
Heart disease (siblings)	0.1	0.2	0.6	-0.2	-0.2	-0.0	0.0	0.1	0.8	-0.3	0.7	-0.0	-0.8
Alcohol drinker status: Previous	2.2	2.5	8.9	0.7	1.3	3.0	2.4	0.8	1.6	0.7	-1.2	-0.6	1.8
Pack years of smoking	0.7	1.0	2.0	0.8	0.8	1.2	1.2	1.4	1.2	-1.2	-0.2	-0.8	-0.3
Impedance of whole body	0.3	1.3	4.6	0.3	0.4	-0.0	0.4	1.8	0.4	-2.1	0.7	-1.1	-1.6
Leg fat mass (left)	0.1	0.5	1.6	-0.1	0.1	-1.1	-0.9	-1.3	-0.6	0.7	-0.0	0.5	-0.2
Arm predicted mass (left)	0.7	3.7	13.4	-1.1	-1.0	-1.0	-1.4	-3.7	-0.6	3.4	0.5	2.5	0.5