TWAS hub - TMEM147

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0666	0.0153	4.5e-08	0.054	0.022	0.047	0.045	0.053	4.9e-17	9.8e-08	6.5e-15	1.8e-14	1.4e-16
2	TCGA	Liver Hepatocellular Carcinoma	0.1650	0.0550	1.9e-05	0.208	0.107	0.190	NA	0.200	4.0e-10	1.0e-05	2.6e-09	NA	9.3e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Platelet Count	11.0	127.7	127.7	-11.3	-11.3
Blood clot in the leg (DVT)	7.8	10.1	10.1	3.2	3.2
Pain type(s) experienced in last month: Hip pain	5.4	6.8	6.9	2.6	2.6
Deep venous thrombosis (DVT) (self-reported)	5.3	6.9	7.0	2.6	2.6
Medication: Atenolol	4.4	5.5	5.8	-2.3	-2.4
Medication: Simvastatin	4.2	6.1	6.2	-2.5	-2.5
Happiness	4.2	5.1	5.2	2.3	2.2
Pain experienced in last month	3.8	6.4	6.4	-2.5	-2.5
Serious illness, injury or assault of a close relative in last 2 years	3.7	4.2	4.2	2.0	2.1
Commuting to job workplace: Public transport	3.5	4.1	4.3	2.1	2.0
Type 2 Diabetes (T2D) (2012)	3.4	4.0	4.0	2.0	2.0
Eye problems/disorders: None of the above	3.4	4.0	4.1	-1.9	-2.0
Eye problems/disorders: Cataract	3.3	3.9	4.0	1.9	2.0
Hearing difficulty/problems: Yes	3.2	4.9	5.0	-2.2	-2.2
Headache pain in last month	3.2	5.6	5.8	2.3	2.4
Osteoarthritis (self-reported)	3.0	3.9	4.0	2.0	2.0
Average weekly beer plus cider intake	3.0	4.4	4.6	-2.1	-2.1
Cardiovascular Disease	2.9	9.6	9.7	-3.1	-3.1
Pulse rate	2.9	4.9	5.0	2.2	2.2
Irritability	2.9	4.9	5.1	2.2	2.3
Allergy	2.6	5.9	6.2	-2.4	-2.5
Medication: Gliclazide	2.6	2.9	3.0	1.7	1.7
Had menopause	2.5	3.2	3.3	-1.7	-1.8
Diverticular disease/diverticulitis (self-reported)	2.4	2.9	3.0	-1.7	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	5.2	2.2	2.3
Medication for cholesterol	2.3	3.5	3.5	1.9	1.8
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	2.9	1.7	1.7
Qualifications: CSEs or equivalent	2.1	2.7	2.9	-1.7	-1.6
Stomach or abdominal pain in last month	2.1	2.7	2.7	1.6	1.6
Average weekly fortified wine intake	1.9	2.3	2.4	1.5	1.5
Fluid intelligence score	1.9	3.9	4.1	1.9	2.0
Hayfever, allergic rhinitis or eczema	1.7	3.7	3.8	1.9	1.9
Pulse wave Arterial Stiffness index	1.7	2.0	2.1	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	2.7	1.6	1.6
Leg pain on walking	1.7	2.1	2.2	1.4	1.5
Medication: Bendroflumethiazide	1.6	2.5	2.5	-1.6	-1.6
Risk taking	1.6	2.3	2.3	1.5	1.5
Alcohol drinker status: Previous	1.6	1.9	1.9	1.3	1.4
Alcohol usually taken with meals	1.5	2.4	2.4	1.6	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	2.5	1.5	1.6
Father’s age at death	1.5	2.0	2.0	-1.4	-1.4
Diabetes diagnosed by doctor	1.5	2.4	2.4	1.6	1.5
Medication: Blood pressure	1.5	2.8	2.8	-1.7	-1.7
Myopia	1.5	2.2	2.2	-1.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	3.2	1.8	1.8
Diabetes (self-reported)	1.4	2.2	2.2	1.5	1.5
Medication: Aspirin	1.4	1.8	1.8	-1.3	-1.3
Prostate Cancer	1.3	1.8	2.0	1.3	1.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	1.8	1.3	1.4
Illnesses of siblings	1.3	1.8	1.8	1.4	1.3
Trunk fat-free mass	1.3	7.7	8.0	2.7	2.8
Trunk predicted mass	1.3	7.7	8.0	2.7	2.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	1.7	1.3	1.3
Wheeze or whistling in the chest in last year	1.3	2.3	2.4	1.5	1.6
Pulse wave peak to peak time	1.3	1.6	1.7	-1.3	-1.2
Overall health rating	1.3	2.7	2.8	1.6	1.7
Qualifications: nursing, teaching	1.3	2.0	2.0	1.4	1.4
Verbal and Numeric Reasoning (VNR)	1.2	2.9	3.1	1.6	1.8
Lung cancer (father)	1.2	1.4	1.5	1.1	1.2
Medication: Amlodipine	1.2	1.7	1.7	-1.3	-1.3
Family relationship satisfaction	1.2	1.5	1.5	1.2	1.2
Whole body fat-free mass	1.2	6.6	6.8	2.5	2.6
Schizophrenia (2018)	1.1	2.3	2.4	1.6	1.5
Waist circumference	1.1	4.1	4.3	2.0	2.1
Alcohol intake versus 10 years previously	1.1	1.7	1.7	-1.3	-1.3
Mood swings	1.1	2.0	2.0	1.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	1.4	-1.2	-1.1
Whole body water mass	1.1	6.0	6.2	2.4	2.5
Basal metabolic rate	1.1	5.9	6.1	2.4	2.5
Ever had prostate specific antigen (PSA) test	1.1	1.2	1.3	1.2	1.1
Intelligence (Savage-Jansen 2018)	1.0	3.1	3.2	1.7	1.8
Fed-up feelings	1.0	1.8	2.0	1.3	1.4
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.1	-1.0	-1.0
Hip circumference	1.0	4.1	4.1	2.0	2.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	1.2	1.1	1.0
Medication: Aspirin	1.0	1.3	1.3	-1.1	-1.1
Leg fat-free mass (right)	1.0	5.2	5.2	2.3	2.3
Arm fat-free mass (left)	1.0	5.3	5.5	2.3	2.3
Diastolic blood pressure, automated reading	1.0	3.0	3.0	-1.7	-1.7
Cholesterol lowering medication	1.0	1.4	1.5	-1.2	-1.2
Depressed Affect (Nagel 2018)	0.9	1.8	1.9	1.3	1.4
LDL Cholesterol	0.9	1.4	1.4	-1.2	-1.2
Height	0.9	18.0	18.4	4.2	4.3
Leg fat-free mass (left)	0.9	4.8	4.9	2.2	2.2
Leg predicted mass (left)	0.9	4.8	4.9	2.1	2.2
Financial difficulties in last 2 years	0.9	1.1	1.2	1.0	1.1
Number of live births	0.9	1.2	1.2	1.1	1.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.1	-1.0	-1.0
Arm fat-free mass (right)	0.9	4.7	4.9	2.1	2.2
Shortness of breath walking on level ground	0.9	1.0	1.0	-1.0	-1.0
Arm predicted mass (right)	0.9	4.7	4.9	2.1	2.2
Leg predicted mass (right)	0.9	5.0	5.1	2.2	2.3
Miserableness	0.9	1.6	1.6	1.2	1.3
Hearing aid user	0.9	1.0	1.0	-1.0	-1.0
Ever depressed for a whole week	0.9	1.2	1.2	1.1	1.1
Heart disease (siblings)	0.9	1.2	1.3	-1.1	-1.0
Ovarian Cancer	0.8	1.0	1.1	-1.0	-1.1
Systolic Blood Pressure	0.8	4.0	4.0	-2.0	-2.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	1.6	1.3	1.2
Diabetes (father)	0.8	1.0	1.0	-0.9	-1.0
Impedance of leg (right)	0.8	3.9	3.9	-2.0	-2.0
Impedance of leg (left)	0.8	3.8	3.8	-1.9	-1.9
Had other major operations	0.8	0.9	1.0	0.9	1.0
Hair/balding pattern: Pattern 3	0.8	1.2	1.2	-1.1	-1.1
Noisy workplace	0.8	1.0	1.0	-1.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.8	1.7	1.7	1.3	1.3
Medication for pain relief, constipation, heartburn	0.8	1.4	1.4	1.2	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	2.2	1.5	1.5
Pack years of smoking	0.8	1.2	1.3	-1.1	-1.1
Bipolar Disorder or Schizophrenia	0.7	1.8	1.8	1.3	1.3
Hand grip strength (right)	0.7	1.9	1.9	-1.4	-1.4
Relative age voice broke	0.7	1.1	1.2	-1.0	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	0.9	0.9	1.0
Hair/balding pattern: Pattern 2	0.7	0.9	1.0	0.9	1.0
Mouth/teeth dental problems	0.7	1.1	1.2	-1.1	-1.1
Medication: Ramipril	0.7	0.9	0.9	0.9	0.9
Asthma	0.7	1.3	1.4	1.1	1.2
Medication: Lansoprazole	0.7	0.8	0.8	0.9	0.9
Handedness (chirality/laterality): Left-handed	0.7	0.8	0.8	0.9	0.9
Guilty feelings	0.7	1.0	1.1	-1.1	-1.0
High cholesterol (Self-reported)	0.7	1.2	1.3	-1.1	-1.1
Medication: Atorvastatin	0.7	0.8	0.8	0.9	0.9
Illnesses of father: High blood pressure	0.7	0.8	0.9	-0.9	-0.9
Arm predicted mass (left)	0.7	3.8	4.0	1.9	2.0
Schizophrenia (2014)	0.6	1.4	1.4	1.2	1.2
Heel T-Score	0.6	4.5	4.6	2.1	2.1
Allergy or Eczema	0.6	1.5	1.6	1.2	1.3
Weight	0.6	3.1	3.3	1.7	1.8
Comparative height size at age 10	0.6	3.2	3.3	1.8	1.8
Supplements: Vitamin C	0.6	0.7	0.7	0.8	0.8
Commuting to job workplace: Walk	0.6	0.7	0.7	-0.8	-0.8
Asthma (self-reported)	0.6	1.1	1.2	1.0	1.1
Illnesses of father: None of the above (group 1)	0.6	0.7	0.7	0.8	0.8
Ever taken oral contraceptive pill	0.6	0.6	0.7	0.8	0.8
Age started oral contraceptive pill	0.6	0.7	0.7	0.9	0.8
Impedance of whole body	0.6	3.2	3.3	-1.8	-1.8
Schizophrenia vs Biploar Disorder	0.5	0.6	0.6	0.8	0.8
Irritable Bowel Disease (IBD)	0.5	1.2	1.2	-1.1	-1.1
Ulcerative Colitis (UC)	0.5	0.9	0.9	-1.0	-0.9
Fasting Glucose	0.5	0.6	0.6	0.8	0.8
Pack years adult smoking proportion	0.5	0.7	0.7	-0.9	-0.8
Medication: Levothyroxine sodium	0.5	0.9	1.0	1.0	0.9
Sitting height	0.5	3.9	4.1	1.9	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	0.9	0.9	1.0
Arm fat mass (right)	0.5	2.0	2.0	1.4	1.4
Loud music exposure frequency	0.5	0.6	0.6	-0.7	-0.8
High blood pressure (siblings)	0.5	0.7	0.7	-0.8	-0.8
Qualifications: College or University degree	0.5	1.6	1.6	1.3	1.3
Illnesses of siblings: Diabetes	0.5	0.6	0.6	-0.8	-0.7
Loneliness, isolation	0.5	0.6	0.7	0.7	0.8
Long-standing illness, disability or infirmity	0.5	0.8	0.9	0.9	1.0
Arm fat mass (left)	0.5	2.2	2.3	1.5	1.5
Fractured/broken bones in last 5 years	0.5	0.7	0.8	-0.8	-0.9
Depression (Nagel 2018)	0.4	0.6	0.7	0.8	0.8
Crohns Disease (2017)	0.4	0.8	0.8	-0.9	-0.9
Breast Cancer	0.4	1.1	1.1	-1.0	-1.1
Age at First Birth	0.4	0.7	0.7	-0.8	-0.8
HDL Cholesterol	0.4	0.7	0.7	0.8	0.8
Neuroticism (2016)	0.4	0.6	0.6	-0.8	-0.8
Lung FVC	0.4	2.2	2.3	1.5	1.5
Supplements: Zinc	0.4	0.4	0.4	0.6	0.7
High blood pressure	0.4	1.1	1.1	-1.1	-1.0
Trunk fat mass	0.4	1.7	1.8	1.3	1.3
Neuroticism score	0.4	0.8	0.9	0.9	0.9
Falls in the last year	0.4	0.5	0.5	0.7	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.5	0.7	0.7
Depression (self-reported)	0.4	0.5	0.5	-0.7	-0.7
Impedance of arm (left)	0.4	1.7	1.8	-1.3	-1.3
Birth weight	0.4	0.8	0.8	-0.9	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.5	-0.7	-0.6
Whole body fat mass	0.4	1.6	1.6	1.2	1.3
Pulse rate, automated reading	0.4	1.3	1.5	1.2	1.1
Hypertension (Self-reported)	0.4	1.2	1.2	-1.1	-1.1
Alzheimer’s Disease (in mother)	0.3	0.4	0.4	-0.6	-0.6
Major Depression (MDD)	0.3	0.4	0.8	0.9	0.0
Lung FEV1/FVC ratio	0.3	1.3	1.3	-1.1	-1.2
Hand grip strength (left)	0.3	0.7	0.7	-0.8	-0.8
Number of treatments/medications taken	0.3	0.5	0.5	-0.7	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.4	-0.6	-0.6
Body mass index (BMI)	0.3	1.4	1.4	1.2	1.2
Number of incorrect matches in round	0.3	0.6	0.6	-0.7	-0.8
Hearing difficulty/problems with background noise	0.3	0.4	0.4	-0.6	-0.6
Forced vital capacity (FVC)	0.3	1.0	1.2	0.9	1.1
Heart attack	0.3	0.4	0.4	0.6	0.6
Impedance of arm (right)	0.3	1.3	1.4	-1.1	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.4	0.7	0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.6	0.8	0.7
Exposure to tobacco smoke outside home	0.3	0.4	0.4	-0.6	-0.6
Medication: Omeprazole	0.3	0.4	0.4	-0.6	-0.6
Number of full sisters	0.3	0.4	0.5	-0.6	-0.7
Had major operations	0.3	0.3	0.4	-0.6	-0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.4	-0.5	-0.6
Knee pain experienced in last month	0.3	0.5	0.5	0.7	0.7
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.5	0.7	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.4	0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.5	0.7	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.3	-0.5	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.3	0.6	0.5
Crohns Disease (2012)	0.2	0.3	0.4	-0.6	-0.6
Blood Red Count	0.2	1.7	1.8	-1.3	-1.3
BMI	0.2	0.9	0.9	0.9	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.3	0.5	0.5
Angina	0.2	0.3	0.3	-0.5	-0.5
Multivitamins +/- minerals	0.2	0.2	0.2	0.5	0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.5	0.5
Nervous feelings	0.2	0.4	0.4	-0.7	-0.6
Pain all over the body in last month	0.2	0.2	0.2	0.4	0.4
Arm fat percentage (right)	0.2	0.9	1.0	1.0	1.0
Time employed in main current job	0.2	0.2	0.2	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.6	0.7	0.8
Standing height	0.2	2.4	2.5	1.5	1.6
Worry too long after embarrassment	0.2	0.3	0.4	0.5	0.6
Health satisfaction	0.2	0.2	0.2	0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.3	-0.5	-0.5
Medication: Ibuprofen	0.2	0.2	0.2	0.5	0.5
Heart disease (mother)	0.2	0.3	0.3	-0.5	-0.5
Leg fat mass (right)	0.2	0.7	0.7	0.8	0.9
Smoking status: Previous	0.2	0.4	0.4	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.4	-0.6	-0.6
Arm fat percentage (left)	0.2	0.8	0.8	0.9	0.9
Ever had bowel cancer screening	0.2	0.2	0.2	-0.4	-0.4
Number of self-reported non-cancer illnesses	0.2	0.3	0.3	-0.6	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.3	0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.2	-0.5	-0.5
Medication: Paracetamol	0.2	0.2	0.3	-0.5	-0.5
Supplements: Calcium	0.2	0.2	0.3	-0.5	-0.5
Leg fat mass (left)	0.2	0.8	0.9	0.9	0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.3	0.5	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.3
Mean Putamen Volume	0.1	0.1	0.1	-0.2	-0.3
Lupus	0.1	0.2	0.2	-0.4	-0.4
Triglycerides	0.1	0.1	0.2	0.4	0.3
Ulcerative Colitis	0.1	0.2	0.2	-0.5	-0.5
Blood Eosinophil Count	0.1	0.7	0.8	-0.9	-0.8
Smoking Status	0.1	0.3	0.4	-0.6	-0.6
Respiratory disease	0.1	0.3	0.3	-0.6	-0.5
Chronotype (morning person)	0.1	0.2	0.2	-0.4	-0.4
Tanning	0.1	1.0	1.0	-1.0	-1.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	0.3
Systolic blood pressure, automated reading	0.1	0.3	0.3	-0.5	-0.6
Medication for hormone replacement therapy	0.1	0.2	0.2	-0.4	-0.4
Vitamin and mineral supplements	0.1	0.1	0.1	-0.3	-0.3
Medication: Co-codamol	0.1	0.1	0.2	0.3	0.4
Severe depression (siblings)	0.1	0.1	0.1	0.3	0.2
Trunk fat percentage	0.1	0.4	0.4	0.6	0.6
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.4	0.3
Current tobacco smoking	0.1	0.1	0.1	-0.4	-0.3
Maternal smoking around birth	0.1	0.2	0.2	-0.4	-0.4
Age when periods started (menarche)	0.1	0.2	0.2	0.4	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.4	0.6	0.7
Medication: Cholesterol lowering	0.1	0.2	0.2	-0.4	-0.4
Illnesses of mother	0.1	0.1	0.1	0.3	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.3	0.2
Birth weight of first child	0.1	0.2	0.2	-0.4	-0.4
Peak expiratory flow (PEF)	0.1	0.3	0.3	0.4	0.6
Pulse wave reflection index	0.1	0.1	0.1	0.3	0.2
Medication: Paracetamol	0.1	0.1	0.1	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.4	0.5	0.6
Body fat percentage	0.1	0.2	0.2	0.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.3	0.3
Age at first live birth	0.1	0.1	0.1	0.3	0.4
Neck or shoulder pain in last month	0.1	0.1	0.1	0.4	0.4
Medication: Allopurinol	0.1	0.1	0.1	-0.3	-0.4
Mean time to correctly identify matches	0.1	0.2	0.3	0.5	0.4
Alcohol intake frequency.	0.1	0.1	0.1	-0.4	-0.3
Chest pain or discomfort	0.1	0.1	0.1	-0.3	-0.2
Age at last live birth	0.1	0.2	0.2	0.4	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.3	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.3	-0.4
Back pain experienced in last month	0.1	0.2	0.2	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.4	0.4
Financial situation satisfaction	0.1	0.1	0.1	-0.2	-0.3
Medication: Lisinopril	0.1	0.1	0.1	-0.3	-0.3
Alcohol drinker status: Never	0.1	0.1	0.1	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	-0.4
Bipolar Disorder (2018)	0.0	0.1	0.1	0.2	0.2
Worry (Nagel 2018)	0.0	0.0	0.0	-0.0	-0.0
Reaction Time	0.0	0.1	0.1	-0.2	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.0	0.1	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	0.1
Rheumatoid Arthritis	0.0	0.0	0.0	-0.0	-0.1
Blood White Count	0.0	0.0	0.0	0.1	0.1
Waist Hip Ratio (WHR)	0.0	0.1	0.1	-0.3	-0.2
Hypothyroidism (self reported)	0.0	0.0	0.0	-0.0	-0.1
Neuroticism	0.0	0.0	0.0	0.1	0.2
Hair Pigment	0.0	0.4	0.4	0.6	0.6
Average weekly spirits intake	0.0	0.1	0.1	0.2	0.3
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.3	-0.2
Relative age of first facial hair	0.0	0.1	0.1	0.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	0.2
Medication: Metformin	0.0	0.0	0.1	0.2	0.2
Diabetes (mother)	0.0	0.0	0.0	0.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.2	-0.1
Taking other prescription medications	0.0	0.0	0.0	0.2	0.2
Serious illness, injury or assault to yourself	0.0	0.1	0.1	0.3	0.2
Supplements: Glucosamine	0.0	0.0	0.0	-0.2	-0.2
High blood pressure (mother)	0.0	0.0	0.0	0.1	0.2
Past tobacco smoking	0.0	0.0	0.0	0.1	0.1
Qualifications: None of the above	0.0	0.0	0.1	-0.2	-0.2
Worrier / anxious feelings	0.0	0.0	0.0	-0.1	-0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.0	0.0
Prospective memory result	0.0	0.0	0.0	-0.2	-0.2
Length of working week for main job	0.0	0.0	0.0	0.1	0.0
Breastfed as a baby	0.0	0.1	0.1	0.2	0.3
Tense / ‘highly strung’	0.0	0.0	0.0	0.2	0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.4	0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.2	0.2
Glaucoma (self-reported)	0.0	0.0	0.1	-0.2	-0.2
Gout (self-reported)	0.0	0.0	0.0	0.1	0.1
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.2	-0.1
Leg fat percentage (right)	0.0	0.0	0.0	-0.1	-0.0
Comparative body size at age 10	0.0	0.1	0.1	0.3	0.3
Number of full brothers	0.0	0.0	0.0	-0.2	-0.2
Number of children fathered	0.0	0.0	0.0	0.1	0.1
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.1	-0.1
Medication: Blood pressure	0.0	0.0	0.0	0.2	0.2
Angina (self-reported)	0.0	0.0	0.1	-0.2	-0.2
Migraine (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.3	0.2
Suffer from ‘nerves’	0.0	0.0	0.0	-0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.1
Average weekly red wine intake	0.0	0.0	0.0	0.1	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.2	-0.2
Friendships satisfaction	0.0	0.0	0.0	-0.2	-0.2
Mineral and other dietary supplements	0.0	0.0	0.0	0.1	0.1
Breast cancer (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Osteoporosis (self-reported)	0.0	0.0	0.0	0.1	0.1
Smoking status: Current	0.0	0.1	0.1	-0.3	-0.2
Wears glasses or contact lenses	0.0	0.0	0.0	-0.0	-0.1
Mother’s age at death	0.0	0.0	0.0	-0.1	0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.2	-0.2
Ever smoked	0.0	0.0	0.0	0.0	0.0
Leg fat percentage (left)	0.0	0.0	0.0	-0.1	-0.0
Number of operations (self-reported)	0.0	0.0	0.0	-0.2	-0.2
Unable to work because of sickness or disability	0.0	0.0	0.0	0.1	0.2
Commuting to job workplace: Cycle	0.0	0.0	0.0	-0.0	-0.0

Hub : Genes

TMEM147

Models

Trait associations