Hub : Genes

TNC

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.057 0.023 4.6e-03 -0.002 0.028 0.016 0.023 0.004 6.6e-01 0.00022 4.0e-03 0.00075 9.8e-02
2 GTEx Cells Transformed fibroblasts 0.113 0.043 1.9e-03 0.086 NA 0.027 NA 0.078 5.4e-07 NA 3.8e-03 NA 1.7e-06
3 GTEx Testis 0.272 0.062 1.0e-06 0.271 NA 0.197 NA 0.250 1.9e-12 NA 4.0e-09 NA 1.9e-11
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.112 0.052 9.5e-04 0.102 0.057 0.082 NA 0.094 1.9e-06 0.00036 2.0e-05 NA 4.7e-06
5 TCGA Thyroid Carcinoma 0.064 0.028 5.3e-04 0.031 0.014 0.012 NA 0.013 4.7e-04 0.01500 2.3e-02 NA 1.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.4 2.2 3.8 -1.9 0.8 -1.7 1.0 -1.8
Bipolar Disorder or Schizophrenia 0.8 1.8 5.9 -1.6 2.4 -0.2 -0.3 -0.9
Depressed Affect (Nagel 2018) 0.4 0.9 2.6 -0.5 -0.2 1.6 -0.7 0.9
Depression (Nagel 2018) 0.3 0.4 0.9 0.0 -0.4 0.8 -0.6 1.0
Intelligence (Savage-Jansen 2018) 1.4 4.3 8.7 1.3 -1.7 -3.0 2.2 -1.8
Neuroticism (Nagel 2018) 0.4 1.0 2.6 -0.2 -0.5 1.6 -0.4 1.3
Schizophrenia (2018) 0.9 1.8 6.4 -0.5 2.5 1.1 -1.1 0.3
Schizophrenia vs Biploar Disorder 0.4 0.5 1.0 0.0 0.6 0.9 -0.8 1.0
Worry (Nagel 2018) 0.2 0.4 1.0 -0.9 0.1 -0.5 1.0 -0.1
Alzheimer’s Disease (in mother) 1.0 1.2 2.6 -1.6 -0.0 0.6 -1.4 0.9
Alzheimer’s Disease (in father) 0.4 0.4 1.2 1.1 -0.3 0.0 -0.6 0.6
Alzheimer’s Disease (including proxy) 1.1 1.5 3.8 -0.8 0.2 1.2 -1.9 1.3
Crohns Disease (2017) 1.1 2.3 4.8 -2.1 0.1 -0.6 1.4 -2.2
Irritable Bowel Disease (IBD) 1.9 4.6 17.1 -4.1 0.3 -1.3 0.7 -1.8
Ulcerative Colitis (UC) 1.9 3.7 14.9 -3.9 0.7 -1.5 -0.0 -0.8
Major Depression (MDD) 1.4 1.7 2.6 1.3 1.3 0.5 -1.4 1.6
Reaction Time 1.5 2.9 10.4 -3.2 1.8 -0.5 -0.7 -0.2
Verbal and Numeric Reasoning (VNR) 1.0 2.4 4.6 1.2 -1.2 -2.1 1.6 -1.4
Breast Cancer 1.4 3.3 11.1 1.6 -3.3 -0.4 1.0 -1.3
Ovarian Cancer 0.6 0.8 1.3 0.4 -0.9 -1.1 0.6 -1.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.5 1.4 -1.2 -1.0 -0.2 0.1 0.3
Bipolar Disorder (2011) 0.6 0.6 1.4 -1.2 -0.5 -0.9 -0.4 -0.4
Body Mass Index (BMI) (2010) 0.9 1.3 3.0 0.1 1.7 -0.8 1.4 -0.9
Coronary Artery Disease (CAD) 0.3 0.4 0.6 -0.2 0.7 -0.6 0.5 -0.8
Crohns Disease (2012) 1.9 3.1 5.8 -2.1 0.0 -1.3 1.8 -2.4
Mean Putamen Volume 1.7 2.0 3.9 0.3 -0.5 -1.4 1.9 -2.0
Fasting Glucose 1.8 2.1 5.5 1.3 -2.3 1.6 -0.4 0.8
HbA1C 0.3 0.3 0.5 0.5 -0.7 0.6 0.4 -0.7
HDL Cholesterol 0.6 0.9 1.9 0.3 1.2 0.6 -1.0 1.4
LDL Cholesterol 1.3 2.0 3.7 0.8 -1.9 1.2 -1.2 1.6
Lupus 0.4 0.5 2.1 -1.4 -0.2 -0.5 0.6 -0.3
Neuroticism (2016) 0.9 1.3 4.4 0.8 2.1 0.6 -0.4 0.9
Primary Biliary Cirrhosis 2.4 3.4 6.2 0.6 -0.5 -2.5 2.3 -2.3
Rheumatoid Arthritis 0.6 0.9 3.1 -1.8 0.5 -0.4 0.8 -0.5
Schizophrenia (2014) 1.4 3.1 8.5 -1.8 2.9 0.9 -1.6 0.6
Triglycerides 0.2 0.3 1.0 0.2 0.3 1.0 -0.5 0.5
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.9 -0.3 -0.6 -0.5 0.9 -0.8
Ulcerative Colitis 1.6 2.3 10.5 -3.2 0.2 -0.8 -0.5 -0.2
Blood Eosinophil Count 0.3 2.0 7.2 2.7 0.4 1.4 -0.4 -0.4
Blood Platelet Count 0.1 0.8 1.8 -1.2 -0.4 -0.5 -0.6 1.4
Blood Red Count 0.1 0.6 1.4 0.4 -1.2 0.8 0.8 -0.0
Blood White Count 0.1 1.0 3.3 0.3 0.4 1.8 -0.7 1.0
Heel T-Score 0.8 6.3 9.2 1.7 -1.6 2.9 -3.0 2.9
BMI 1.9 11.2 25.0 3.2 0.8 -3.3 5.0 -3.0
Height 1.9 35.7 84.3 -5.0 -1.6 6.4 -9.2 5.0
Waist Hip Ratio (WHR) 1.7 7.7 19.0 0.5 0.2 2.8 -3.4 4.4
Systolic Blood Pressure 0.3 1.4 4.1 0.3 -0.4 -2.0 1.4 -0.9
Smoking Status 0.5 1.2 2.6 -0.4 -1.6 1.4 -1.0 0.7
Allergy or Eczema 1.1 2.9 8.4 -0.0 -0.4 2.9 -2.1 1.2
Cardiovascular Disease 1.0 3.2 12.2 3.5 0.2 -1.1 1.3 -0.8
Hypothyroidism (self reported) 0.2 0.6 1.0 0.9 0.6 -1.0 0.8 -0.0
Respiratory disease 0.3 0.7 1.8 1.2 -0.3 1.3 0.1 0.5
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.0 -0.2 0.5 0.7 -1.0 0.8
Lung FEV1/FVC ratio 0.3 1.3 3.5 -0.9 0.5 -0.3 1.3 -1.9
Lung FVC 0.9 4.4 17.4 -0.8 -4.2 1.1 -0.0 1.6
Neuroticism 0.3 0.6 1.8 -0.5 -0.0 1.4 -0.2 1.0
Chronotype (morning person) 0.7 1.7 3.4 1.2 1.9 0.6 -0.4 1.7
Hair Pigment 0.0 0.6 0.9 -0.9 -0.5 -0.7 0.9 -0.7
Tanning 0.2 2.7 4.7 -2.2 -0.1 1.9 -2.0 0.9
Hand grip strength (left) 0.4 1.0 1.9 -0.8 0.9 -0.7 0.9 -1.4
Number of treatments/medications taken 0.2 0.4 0.8 0.3 -0.2 -0.9 0.7 -0.6
Average weekly spirits intake 0.2 0.3 1.2 0.3 0.2 -0.4 0.1 -1.1
Sensitivity / hurt feelings 3.0 5.2 10.2 1.6 2.7 3.2 -1.3 2.0
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.3 0.5 0.1 0.3 0.4
Hearing difficulty/problems: Yes 0.6 0.9 2.0 0.1 0.5 1.1 -1.4 1.0
Relative age of first facial hair 0.1 0.2 0.6 -0.3 -0.8 -0.3 -0.3 -0.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.4 -0.6 1.2 -0.1 -0.4 0.5
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.8 1.3 -1.1 -0.6 0.7 -0.5
Ever had hysterectomy (womb removed) 1.5 1.7 3.8 1.2 0.4 -0.6 1.7 -2.0
Systolic blood pressure, automated reading 0.2 0.6 1.0 -0.6 0.3 -0.9 1.0 -0.7
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.7 0.9 -1.3 -1.0 1.1 -1.0
Angina 0.9 1.2 2.9 -0.0 0.3 -1.7 1.7 -0.4
Medication for hormone replacement therapy 1.7 1.9 4.2 0.4 -2.0 -1.7 0.8 -1.3
Vitamin and mineral supplements 1.5 2.1 4.8 1.7 -0.3 0.9 -1.3 2.2
Supplements: Zinc 0.1 0.1 0.3 0.2 0.2 0.1 0.2 -0.5
Medication: Co-codamol 2.0 2.3 7.2 2.7 -0.8 1.6 -0.7 0.7
Medication: Metformin 0.3 0.4 0.7 -0.7 0.8 -0.0 -0.7 0.6
Diabetes (father) 0.8 0.9 3.5 -1.9 -0.2 -1.0 -0.1 -0.3
Diabetes (mother) 0.6 0.8 2.9 0.4 1.7 0.1 0.8 -0.2
Severe depression (siblings) 2.3 2.6 4.7 -1.8 0.7 1.1 -1.9 2.2
Pack years adult smoking proportion 0.1 0.2 0.5 -0.4 0.1 0.1 -0.5 0.7
Impedance of leg (right) 2.3 10.9 28.3 1.0 -0.2 3.6 -3.6 5.3
Leg fat-free mass (left) 0.4 1.9 5.4 -1.7 0.3 -1.0 0.7 -2.3
Trunk fat percentage 0.8 3.4 5.8 2.4 2.2 -1.1 2.3 -0.1
Hand grip strength (right) 0.5 1.3 2.4 -0.5 -0.3 -1.4 1.3 -1.5
Townsend deprivation index at recruitment 0.9 1.2 2.4 -1.3 1.0 -0.8 0.7 -1.5
Current tobacco smoking 0.4 0.7 1.9 -1.2 -1.4 -0.0 -0.5 0.4
Average weekly fortified wine intake 0.5 0.6 1.3 -0.8 0.0 -0.9 0.4 -1.2
Maternal smoking around birth 2.0 2.9 6.6 -1.6 0.1 2.6 -2.0 1.2
Fed-up feelings 0.3 0.5 1.3 -0.5 -0.1 -0.1 1.1 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.9 1.0 0.2 0.8 0.7 -0.1
Relative age voice broke 0.1 0.2 0.6 0.4 -0.8 0.0 0.1 0.1
Taking other prescription medications 1.0 1.6 4.4 2.1 -1.7 -0.4 0.4 0.5
Age when periods started (menarche) 0.3 0.8 2.4 -1.6 -0.4 -1.1 0.4 0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.1 0.1 -0.0 -0.8 1.0 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.5 -0.8 0.7 1.6 -1.2 1.3
Tinnitus: Yes, but not now, but have in the past 2.4 2.5 6.3 -0.1 0.2 -1.7 1.8 -2.5
Qualifications: CSEs or equivalent 0.2 0.3 0.6 -0.8 -0.2 -0.5 0.6 -0.1
Serious illness, injury or assault to yourself 1.0 1.2 5.1 -2.3 -0.6 0.5 0.0 0.4
High blood pressure 0.7 1.9 4.6 2.2 -0.5 -0.9 1.3 -1.5
Hayfever, allergic rhinitis or eczema 2.1 4.5 9.8 1.1 -1.1 3.1 -2.7 1.6
Multivitamins +/- minerals 2.4 3.0 8.0 -0.6 1.1 -1.2 2.0 -2.8
Stomach or abdominal pain in last month 0.3 0.3 1.1 -0.1 -1.0 0.2 -0.1 0.8
Supplements: Glucosamine 1.3 1.6 3.6 -1.8 0.4 0.0 1.0 -1.9
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.9 -2.0 0.1 -0.7 0.6 -1.1
Medication: Atenolol 0.2 0.2 0.7 -0.3 -0.8 -0.3 -0.1 0.4
Medication: Levothyroxine sodium 1.2 2.0 3.3 0.7 0.8 -1.8 1.6 -1.7
Sitting height 0.8 5.8 8.7 -3.0 -2.7 -1.8 1.3 -2.9
Chronic bronchitis/emphysema (father) 1.1 1.3 4.9 0.5 2.2 1.0 -0.5 0.3
High blood pressure (mother) 1.9 2.7 10.3 -0.3 3.2 -0.4 1.1 -1.4
Body mass index (BMI) 1.4 5.8 12.4 2.3 1.2 -2.2 3.5 -2.2
Impedance of leg (left) 2.2 10.6 25.5 1.0 0.0 3.6 -3.6 5.1
Leg predicted mass (left) 0.4 2.0 5.5 -1.7 0.4 -0.9 0.7 -2.3
Trunk fat mass 0.5 2.0 3.7 1.6 1.6 -1.0 1.9 -0.6
Waist circumference 0.3 0.9 1.8 1.1 1.3 -0.6 1.1 0.1
Number of incorrect matches in round 0.8 1.3 5.4 -2.3 0.0 0.8 -0.5 0.4
Past tobacco smoking 0.4 0.7 2.4 -1.6 0.6 -0.2 -0.7 0.5
Alcohol usually taken with meals 0.1 0.2 0.7 -0.2 0.4 -0.1 -0.8 0.4
Nervous feelings 0.5 0.9 3.5 -0.7 1.9 0.4 0.7 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 -1.0 1.1 -0.3 0.3 -0.1
Hearing difficulty/problems with background noise 0.3 0.4 1.1 0.2 -0.4 0.6 -1.1 0.7
Hair/balding pattern: Pattern 2 1.2 1.5 2.6 -1.1 1.0 1.6 -1.3 1.0
Had menopause 1.6 2.1 3.5 1.1 -1.8 -0.4 1.4 -1.9
Had other major operations 0.4 0.5 1.4 -1.2 0.6 -0.4 -0.4 0.6
Forced vital capacity (FVC) 1.0 3.9 9.0 -0.9 -3.0 2.0 -1.6 1.7
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 4.0 -0.7 1.0 1.9 -2.0 1.8
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.2 0.1 -0.1 1.1 -0.9 1.5
Qualifications: None of the above 0.4 0.8 1.2 -0.9 1.0 0.4 -1.0 1.1
Financial difficulties in last 2 years 0.2 0.3 1.0 0.3 -0.0 -0.4 1.0 -0.6
Mouth/teeth dental problems 0.9 1.4 6.3 -2.5 -0.3 -0.4 0.6 0.1
Heart attack 0.3 0.3 0.6 -0.1 -0.5 -0.6 0.8 0.7
Allergy 1.7 3.9 11.3 -1.3 1.6 -3.4 1.8 -0.7
Pain all over the body in last month 0.3 0.4 0.7 -0.8 -0.8 0.6 -0.1 0.5
Diabetes (self-reported) 0.4 0.6 1.1 -0.2 0.8 0.9 -1.0 0.8
Hayfever/allergic rhinitis (self-reported) 3.7 4.9 8.0 1.5 -1.4 2.8 -2.8 2.1
Medication: Ramipril 1.0 1.2 1.5 1.0 -1.1 1.2 -1.1 1.1
Medication: Simvastatin 0.4 0.5 2.4 1.6 -0.1 -0.3 -0.3 0.2
Fluid intelligence score 1.9 4.0 7.8 0.9 -0.7 -2.6 2.8 -2.1
Illnesses of siblings 0.3 0.4 1.6 0.2 -1.3 0.3 0.0 0.1
Neuroticism score 0.2 0.5 1.4 -0.3 1.2 0.8 0.5 0.3
Weight 0.1 0.6 1.2 0.2 0.8 -0.5 1.0 -1.1
Impedance of arm (right) 1.2 5.5 12.2 -1.2 3.1 1.1 -1.8 3.5
Arm fat percentage (right) 1.3 5.2 10.8 1.9 2.5 -2.1 3.3 -1.2
Trunk fat-free mass 0.3 1.9 4.3 -2.1 -1.3 0.6 -1.4 -1.1
Hip circumference 0.6 2.4 5.3 -0.1 1.0 -1.9 2.3 -1.5
Time employed in main current job 0.5 0.6 1.0 -0.7 1.0 -0.7 0.9 -0.3
Alcohol intake versus 10 years previously 0.2 0.3 1.0 0.1 1.0 0.6 0.4 0.1
Father’s age at death 1.6 2.2 3.9 -0.0 -1.8 -2.0 1.3 -1.4
Worrier / anxious feelings 0.3 0.5 1.7 0.1 0.8 0.4 1.3 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.7 -0.9 -0.2 0.9 0.6 -0.9
Falls in the last year 0.8 1.0 3.3 0.6 0.0 1.8 -0.8 0.9
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.0 0.7 -0.8 0.6 -0.5
Number of live births 0.2 0.3 0.7 -0.6 0.8 -0.2 0.6 -0.5
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 5.0 -0.8 -2.2 2.0 -1.6 1.6
Pulse rate 0.3 0.5 1.6 0.6 -1.3 -0.6 0.3 0.5
Happiness 0.4 0.5 2.0 1.4 0.1 0.8 -0.1 0.0
Noisy workplace 0.5 0.6 2.3 -1.5 0.8 0.0 0.2 0.2
Qualifications: A levels/AS levels or equivalent 1.2 2.7 8.7 2.1 -2.9 0.4 -0.4 -0.0
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 4.5 -1.5 0.7 -1.4 0.8 -2.1
Mouth/teeth dental problems: Dentures 0.4 0.6 1.9 0.7 1.4 0.5 -0.2 -0.7
Asthma 1.2 2.4 6.1 1.6 -1.7 2.5 -0.5 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.4 1.5 1.0 -0.8 1.1 -0.4
Medication: Cholesterol lowering 0.6 1.0 1.9 1.4 -1.2 0.1 -0.5 1.2
Depression (self-reported) 0.3 0.4 1.4 1.2 0.0 -0.8 0.2 0.2
Medication: Lansoprazole 0.3 0.3 1.3 -1.2 -0.2 -0.2 0.3 0.4
Prospective memory result 0.2 0.2 0.5 -0.6 -0.1 0.0 0.5 -0.7
Lung cancer (father) 0.1 0.2 0.5 -0.2 -0.2 -0.7 0.4 -0.0
Illnesses of mother 1.5 1.9 4.7 2.2 -1.9 0.8 -0.4 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 4.0 6.0 -1.4 -1.2 2.2 -2.4 2.5
Pulse wave Arterial Stiffness index 1.2 1.4 4.3 -2.1 0.7 0.7 -1.2 0.7
Impedance of arm (left) 0.8 3.5 8.2 -0.4 2.5 1.0 -1.4 2.9
Arm fat mass (right) 0.9 3.6 7.2 1.4 1.7 -1.8 2.7 -1.5
Trunk predicted mass 0.3 1.9 4.3 -2.1 -1.3 0.7 -1.5 -1.0
Standing height 1.2 12.4 27.4 -4.1 -0.7 3.5 -5.2 2.3
Length of working week for main job 3.1 3.4 11.8 3.4 1.8 1.3 0.2 0.7
Exposure to tobacco smoke at home 0.6 0.7 1.4 -0.4 -1.0 -0.7 0.6 -1.2
Breastfed as a baby 0.3 0.4 1.2 0.4 -0.2 0.5 -0.6 -1.1
Tense / ‘highly strung’ 0.5 0.8 3.1 -1.8 1.0 -0.1 0.1 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.5 -0.1 0.0 -1.3 1.9 -1.6
Hair/balding pattern: Pattern 4 0.6 1.4 3.6 -1.1 0.2 -1.9 1.2 -0.9
Birth weight of first child 2.3 4.2 10.9 0.3 -3.3 -2.0 1.8 -1.7
Peak expiratory flow (PEF) 0.4 0.9 2.8 0.8 -1.7 0.6 -0.4 0.8
Pulse wave reflection index 1.0 1.3 4.4 -2.1 1.0 0.3 -0.9 -0.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.5 -0.6 1.0 0.5 -0.4 1.2
Loud music exposure frequency 4.0 4.3 11.3 -0.2 0.4 2.0 -2.5 3.4
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.9 2.0 -0.6 0.1 0.6 -0.6
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 5.2 2.3 0.8 -0.5 0.6 -0.9
Blood clot in the leg (DVT) 1.2 1.5 4.4 -2.1 1.7 0.5 -0.1 -0.2
Medication: Paracetamol 1.0 1.7 4.2 0.0 0.3 1.6 -1.3 2.0
Headache pain in last month 0.5 0.9 3.9 -0.3 2.0 0.2 -0.2 -0.5
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.3 -1.1 0.0 0.0 0.7 -1.1
Glaucoma (self-reported) 0.4 0.4 1.4 -0.4 1.2 -0.4 -0.1 -0.7
Gout (self-reported) 0.2 0.3 0.7 0.5 0.8 -0.0 0.8 -0.2
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 1.8 0.3 1.1 -1.4 1.2 -0.8
Medication: Amlodipine 0.1 0.2 0.6 0.5 -0.8 0.2 -0.1 0.3
Medication: Ventolin 100micrograms inhaler 0.3 0.3 1.0 0.5 0.1 1.0 -0.3 0.5
Birth weight 2.7 5.8 11.8 1.9 -2.9 -1.0 2.2 -3.4
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.5 -0.2 -0.7 0.6 -1.9 1.8
High blood pressure (siblings) 0.2 0.3 0.6 0.4 0.4 -0.7 0.5 -0.8
Forced vital capacity (FVC), Best measure 1.4 5.2 7.7 -1.4 -1.8 2.4 -2.7 2.8
Body fat percentage 1.0 3.8 6.9 2.6 2.0 -1.1 2.6 -0.4
Leg fat percentage (right) 0.7 2.7 7.1 2.7 0.8 -0.7 2.2 0.1
Arm fat-free mass (right) 0.3 1.3 3.1 -0.6 -1.8 0.4 -0.5 -1.7
Exposure to tobacco smoke outside home 0.3 0.4 0.7 0.5 0.7 0.8 -0.6 0.3
Comparative body size at age 10 1.6 4.3 6.8 -0.8 -1.6 -2.5 2.6 -2.3
Number of full brothers 1.1 1.4 3.0 0.8 0.5 -0.9 1.5 -1.7
Worry too long after embarrassment 0.8 1.4 5.3 0.5 0.5 2.3 -0.6 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.8 -0.0 0.2 0.0 0.9 -0.9
Wheeze or whistling in the chest in last year 0.7 1.2 3.1 1.2 -0.9 1.8 0.1 -0.8
Number of children fathered 0.2 0.2 0.7 0.6 -0.3 0.0 0.2 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 5.5 1.3 -2.4 0.1 0.8 -0.9
Age at first live birth 1.3 2.3 6.6 -2.6 -0.9 -0.4 -1.3 1.4
Pulse wave peak to peak time 0.9 1.1 2.8 1.7 -0.8 -0.6 1.0 -0.8
Health satisfaction 1.4 1.8 7.3 2.7 -0.4 0.3 -0.4 1.1
Shortness of breath walking on level ground 1.0 1.2 2.7 0.5 0.9 0.5 -1.4 1.6
Qualifications: College or University degree 0.2 0.5 0.9 0.8 -0.1 0.9 -0.9 0.1
Eye problems/disorders: None of the above 1.8 2.1 3.4 -0.9 -0.5 1.8 -1.6 1.9
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.2 -1.4 -0.5 -1.5 1.0 -0.5
Emphysema/chronic bronchitis 0.6 0.6 2.1 0.1 -0.2 -1.0 0.3 -1.5
Medication for pain relief, constipation, heartburn 0.2 0.4 0.6 -0.8 -0.6 0.8 -0.4 -0.4
Neck or shoulder pain in last month 2.2 3.1 5.5 0.6 -0.6 -2.3 2.1 -2.3
Medication: Blood pressure 0.1 0.2 0.5 0.6 -0.3 -0.3 -0.2 0.7
Angina (self-reported) 1.4 1.8 4.6 -0.5 -0.1 -2.1 2.0 -0.6
Migraine (self-reported) 0.6 0.7 1.3 -0.4 -1.0 -0.5 1.0 -1.1
Medication: Ibuprofen 0.6 0.7 1.6 0.9 1.3 -0.6 0.5 -0.5
Medication: Allopurinol 0.2 0.2 0.7 0.3 0.8 -0.2 0.6 -0.3
Medication: Omeprazole 1.0 1.2 4.0 0.8 -2.0 0.1 -0.8 0.8
Medication: Seretide 50 evohaler 3.2 3.7 7.8 1.0 -2.0 2.8 -2.0 1.2
Mean time to correctly identify matches 1.6 3.1 12.4 -3.5 1.2 -0.8 -0.3 -1.0
Heart disease (mother) 2.7 3.2 4.8 -1.4 1.6 -2.2 1.7 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.0 2.4 10.1 3.2 -0.5 1.1 -0.0 0.7
Whole body fat mass 0.5 2.3 4.9 1.6 1.4 -1.2 2.2 -0.8
Leg fat mass (right) 0.5 2.1 5.1 1.5 0.9 -1.2 2.2 -0.8
Arm predicted mass (right) 0.3 1.4 3.2 -0.7 -1.8 0.4 -0.4 -1.8
Pulse rate, automated reading 0.4 1.3 3.9 1.2 -2.0 -0.1 1.0 -0.3
Alcohol intake frequency. 0.4 0.9 1.5 1.0 1.2 1.2 0.1 0.8
Comparative height size at age 10 1.4 7.9 19.5 -4.4 0.6 1.9 -3.7 1.4
Number of full sisters 2.7 3.3 5.5 0.2 -0.9 2.2 -2.4 2.3
Suffer from ‘nerves’ 0.2 0.3 0.9 0.1 1.0 -0.0 0.3 -0.7
Overall health rating 0.3 0.6 1.4 0.6 0.1 -0.2 1.1 -1.2
Chest pain or discomfort 1.8 2.6 8.1 2.9 -1.8 0.1 1.0 -0.7
Had major operations 1.9 2.3 6.9 0.5 2.6 1.4 -0.8 1.3
Age at last live birth 1.0 1.4 2.9 -1.7 -0.8 0.5 -1.4 1.1
Family relationship satisfaction 1.8 2.2 6.1 2.5 -1.2 1.5 -0.9 0.5
Leg pain on walking 2.0 2.5 4.6 0.1 -2.2 1.7 -1.6 1.5
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 4.1 1.5 1.4 -0.5 2.0 -1.1
Commuting to job workplace: Car/motor vehicle 1.1 1.2 2.3 1.4 -0.7 -0.4 1.5 -1.2
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 4.3 2.1 -1.1 1.2 -1.3 0.6
Medication: Aspirin 0.5 0.6 2.2 -0.2 -0.1 -1.5 0.9 0.3
Supplements: Vitamin C 1.8 2.1 5.1 -1.2 -2.3 -0.4 0.8 -1.8
Knee pain experienced in last month 0.6 1.0 2.5 -0.0 1.6 1.5 -0.5 0.1
Hypertension (Self-reported) 0.5 1.5 5.1 2.2 -0.2 -0.2 0.9 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.9 -0.8 0.6 0.3 -1.1 1.4
Illnesses of father: Heart disease 0.6 0.8 1.4 -1.0 0.9 -1.2 0.7 -0.7
Illnesses of siblings: Diabetes 1.2 1.5 4.5 -1.1 0.5 0.2 -1.3 2.1
Smoking status: Previous 0.4 0.7 1.2 1.1 -0.7 -0.1 1.1 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.1 4.5 9.0 -1.7 1.6 1.9 -3.0 2.1
Whole body fat-free mass 0.3 1.5 3.6 -1.9 -0.7 0.1 -0.6 -1.7
Leg fat-free mass (right) 0.5 2.5 6.8 -1.9 0.4 -1.1 0.7 -2.6
Arm fat percentage (left) 1.6 6.4 13.5 2.2 2.3 -2.3 3.7 -1.7
Average weekly red wine intake 0.7 1.1 2.9 0.2 -1.7 -0.2 -1.5 0.4
Handedness (chirality/laterality): Left-handed 2.3 2.8 7.1 -0.9 2.7 -2.1 1.1 -0.9
Mood swings 0.2 0.3 0.8 0.2 0.8 0.9 -0.0 -0.1
Loneliness, isolation 0.5 0.7 2.0 -0.1 -1.4 0.4 -0.6 1.1
Long-standing illness, disability or infirmity 0.3 0.4 0.6 0.1 0.8 -0.7 0.7 -0.6
Ever had bowel cancer screening 0.2 0.3 0.5 0.6 -0.2 0.7 -0.4 0.6
Diabetes diagnosed by doctor 0.3 0.5 1.0 -0.1 0.7 0.7 -1.0 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.4 -0.7 -0.7 0.1 -1.3 1.5
Friendships satisfaction 2.9 3.7 5.7 2.0 1.0 2.4 -1.9 2.0
Qualifications: nursing, teaching 1.1 1.7 3.1 1.8 0.2 1.1 -1.6 1.3
Commuting to job workplace: Walk 0.3 0.3 0.6 -0.4 0.7 -0.3 -0.8 0.4
Eye problems/disorders: Cataract 1.2 1.4 2.5 -1.1 0.9 -1.2 1.0 -1.6
Mouth/teeth dental problems: Mouth ulcers 3.3 5.2 12.2 3.5 -2.0 2.3 -1.7 1.3
Medication for cholesterol 1.4 2.2 3.4 -1.9 1.4 1.0 -1.4 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 6.8 -0.3 -1.1 -1.6 1.9 -2.6
Back pain experienced in last month 1.5 2.2 5.3 0.9 -2.3 -1.4 1.2 -1.0
Mineral and other dietary supplements 1.5 2.0 5.8 2.4 -0.7 0.1 -0.7 1.7
Breast cancer (self-reported) 0.4 0.5 1.7 -0.0 -0.5 0.4 -0.6 1.3
Asthma (self-reported) 1.1 2.3 5.9 1.7 -1.3 2.4 -0.5 0.7
Osteoporosis (self-reported) 0.6 0.7 2.0 -1.2 -0.2 -1.4 0.2 -0.1
Osteoarthritis (self-reported) 1.0 1.3 2.2 1.5 -1.4 1.3 -0.7 0.2
Medication: Aspirin 0.7 0.9 3.0 -0.3 0.1 -1.7 1.2 -0.0
Medication: Gliclazide 1.4 1.6 3.1 0.0 1.8 0.8 -1.2 1.6
Illnesses of father: None of the above (group 1) 0.1 0.2 0.5 -0.7 -0.3 0.2 0.3 -0.3
Smoking status: Current 0.4 0.7 1.8 -1.1 -1.3 0.1 -0.7 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.4 0.4 -1.2 0.5 0.1 0.3
Whole body water mass 0.3 1.5 3.4 -1.9 -0.7 0.1 -0.5 -1.9
Leg predicted mass (right) 0.5 2.5 7.0 -1.9 0.4 -1.0 0.7 -2.6
Arm fat mass (left) 1.0 4.0 8.0 1.6 1.6 -1.8 2.8 -1.8
Number of self-reported non-cancer illnesses 0.6 1.0 2.0 1.4 -0.8 1.4 -0.6 0.2
Average weekly champagne plus white wine intake 0.6 0.8 1.9 -1.0 -0.9 -1.4 -0.4 -0.1
Miserableness 0.5 0.9 2.2 0.8 1.3 1.5 0.1 -0.0
Guilty feelings 0.5 0.7 1.2 -1.1 -0.1 -0.8 1.0 -0.9
Wears glasses or contact lenses 0.7 0.8 2.7 -0.0 0.4 -1.6 0.8 -0.8
Ever taken oral contraceptive pill 0.7 0.8 1.6 -1.3 0.5 -0.3 -0.8 1.2
Hearing aid user 1.2 1.4 2.7 0.7 -0.3 1.1 -1.7 1.6
Mother’s age at death 0.2 0.3 1.3 -1.1 0.1 -0.0 -0.3 -0.2
Financial situation satisfaction 0.5 0.7 1.3 0.6 1.1 -0.9 1.0 -0.2
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.0 -0.9 0.1 -0.5 1.0 -0.5
Commuting to job workplace: Public transport 0.1 0.1 0.5 0.1 0.0 -0.1 0.1 -0.7
Eye problems/disorders: Glaucoma 1.6 1.8 4.0 0.8 1.1 -1.2 1.4 -2.0
Medication: Blood pressure 1.0 1.9 3.6 1.9 -0.8 -0.6 1.6 -1.5
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.6 0.6 -1.0 1.9 -1.1 0.8
Supplements: Fish oil (including cod liver oil) 1.4 1.8 6.4 -1.1 0.9 -0.3 0.7 -2.5
High cholesterol (Self-reported) 1.2 2.2 5.1 2.3 -1.7 0.7 -0.9 1.3
Medication: Bendroflumethiazide 0.2 0.3 0.7 0.5 -0.5 0.5 -0.8 0.4
Medication: Paracetamol 0.6 1.0 1.4 -0.4 1.1 1.0 -1.0 1.2
Medication: Lisinopril 2.2 2.9 6.0 -0.2 -0.6 -2.3 2.4 -1.7
Medication: Atorvastatin 0.5 0.6 1.3 0.2 -1.2 -0.7 0.0 1.1
Illnesses of father: High blood pressure 0.4 0.5 1.8 1.4 0.6 -0.2 0.0 -0.4
Alcohol drinker status: Never 0.9 1.1 3.8 -0.0 -0.3 -1.9 0.8 -1.0
Ever smoked 0.1 0.1 0.3 0.6 0.0 0.4 0.1 0.0
Basal metabolic rate 0.2 0.9 2.5 -1.4 -0.3 -0.0 -0.2 -1.6
Leg fat percentage (left) 0.9 3.3 8.7 3.0 0.9 -0.9 2.4 -0.3
Arm fat-free mass (left) 0.2 0.9 1.5 -0.8 -1.0 0.6 -0.8 -1.2
Number of operations (self-reported) 0.2 0.3 0.8 0.4 0.9 0.5 0.4 -0.3
Average weekly beer plus cider intake 1.2 1.7 2.8 1.6 0.9 1.7 -0.7 1.3
Irritability 0.3 0.5 1.4 1.2 -0.7 0.6 0.2 0.5
Risk taking 2.7 3.9 9.7 -0.0 -1.2 2.1 -3.1 2.1
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.9 0.3 0.3 0.5 0.3 -1.4
Fractured/broken bones in last 5 years 1.1 1.4 2.1 -0.9 -0.5 1.4 -1.4 1.3
Age started oral contraceptive pill 0.7 0.9 3.2 -0.8 1.8 -0.3 -0.4 -0.4
Diastolic blood pressure, automated reading 0.4 1.4 4.4 0.7 -0.8 -0.6 2.1 -1.0
Ever depressed for a whole week 1.0 1.2 3.2 0.4 -0.1 1.1 -1.1 1.8
Unable to work because of sickness or disability 0.4 0.5 1.4 -0.4 -0.8 0.0 0.6 -1.2
Commuting to job workplace: Cycle 1.7 2.0 3.4 -1.9 -1.6 1.5 -1.2 0.5
Myopia 0.5 0.7 1.3 -1.1 1.2 -0.0 0.2 -0.8
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.2 -1.8 -0.1 1.2 -1.5 1.1
Cholesterol lowering medication 0.3 0.4 1.0 1.0 -0.6 -0.6 0.4 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 6.3 0.6 -2.5 0.1 -1.1 1.6
Pain experienced in last month 0.2 0.3 0.7 -0.6 0.5 -0.9 0.5 -0.1
Supplements: Calcium 0.9 1.0 2.3 -1.5 0.2 -0.1 0.7 -1.5
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 0.1 0.9 0.7 -0.7 -0.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 0.1 -0.5 -0.7 1.0 0.3
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 3.6 -1.9 1.3 0.4 -0.2 -0.2
Heart disease (siblings) 0.6 0.7 1.6 -1.3 1.2 0.5 -0.1 0.3
Alcohol drinker status: Previous 0.9 1.1 3.3 0.6 0.5 0.3 1.1 -1.8
Pack years of smoking 0.1 0.2 0.6 -0.4 -0.1 -0.1 -0.5 0.8
Impedance of whole body 1.3 6.5 18.7 0.5 1.3 2.4 -2.5 4.3
Leg fat mass (left) 0.6 2.5 5.6 1.9 1.0 -1.2 2.4 -1.1
Arm predicted mass (left) 0.2 0.9 1.6 -0.8 -1.1 0.6 -0.7 -1.2