TWAS hub - TNC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.057	0.023	4.6e-03	-0.002	0.028	0.016	0.023	0.004	6.6e-01	0.00022	4.0e-03	0.00075	9.8e-02
2	GTEx	Cells Transformed fibroblasts	0.113	0.043	1.9e-03	0.086	NA	0.027	NA	0.078	5.4e-07	NA	3.8e-03	NA	1.7e-06
3	GTEx	Testis	0.272	0.062	1.0e-06	0.271	NA	0.197	NA	0.250	1.9e-12	NA	4.0e-09	NA	1.9e-11
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.112	0.052	9.5e-04	0.102	0.057	0.082	NA	0.094	1.9e-06	0.00036	2.0e-05	NA	4.7e-06
5	TCGA	Thyroid Carcinoma	0.064	0.028	5.3e-04	0.031	0.014	0.012	NA	0.013	4.7e-04	0.01500	2.3e-02	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Loud music exposure frequency	4.0	4.3	11.3	-0.2	0.4	2.0	-2.5	3.4
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	8.0	1.5	-1.4	2.8	-2.8	2.1
Mouth/teeth dental problems: Mouth ulcers	3.3	5.2	12.2	3.5	-2.0	2.3	-1.7	1.3
Medication: Seretide 50 evohaler	3.2	3.7	7.8	1.0	-2.0	2.8	-2.0	1.2
Length of working week for main job	3.1	3.4	11.8	3.4	1.8	1.3	0.2	0.7
Sensitivity / hurt feelings	3.0	5.2	10.2	1.6	2.7	3.2	-1.3	2.0
Friendships satisfaction	2.9	3.7	5.7	2.0	1.0	2.4	-1.9	2.0
Birth weight	2.7	5.8	11.8	1.9	-2.9	-1.0	2.2	-3.4
Heart disease (mother)	2.7	3.2	4.8	-1.4	1.6	-2.2	1.7	-2.0
Number of full sisters	2.7	3.3	5.5	0.2	-0.9	2.2	-2.4	2.3
Risk taking	2.7	3.9	9.7	-0.0	-1.2	2.1	-3.1	2.1
Primary Biliary Cirrhosis	2.4	3.4	6.2	0.6	-0.5	-2.5	2.3	-2.3
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	6.3	-0.1	0.2	-1.7	1.8	-2.5
Multivitamins +/- minerals	2.4	3.0	8.0	-0.6	1.1	-1.2	2.0	-2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	6.8	-0.3	-1.1	-1.6	1.9	-2.6
Severe depression (siblings)	2.3	2.6	4.7	-1.8	0.7	1.1	-1.9	2.2
Impedance of leg (right)	2.3	10.9	28.3	1.0	-0.2	3.6	-3.6	5.3
Birth weight of first child	2.3	4.2	10.9	0.3	-3.3	-2.0	1.8	-1.7
Handedness (chirality/laterality): Left-handed	2.3	2.8	7.1	-0.9	2.7	-2.1	1.1	-0.9
Impedance of leg (left)	2.2	10.6	25.5	1.0	0.0	3.6	-3.6	5.1
Neck or shoulder pain in last month	2.2	3.1	5.5	0.6	-0.6	-2.3	2.1	-2.3
Medication: Lisinopril	2.2	2.9	6.0	-0.2	-0.6	-2.3	2.4	-1.7
Hayfever, allergic rhinitis or eczema	2.1	4.5	9.8	1.1	-1.1	3.1	-2.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.5	9.0	-1.7	1.6	1.9	-3.0	2.1
Medication: Co-codamol	2.0	2.3	7.2	2.7	-0.8	1.6	-0.7	0.7
Maternal smoking around birth	2.0	2.9	6.6	-1.6	0.1	2.6	-2.0	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	10.1	3.2	-0.5	1.1	-0.0	0.7
Leg pain on walking	2.0	2.5	4.6	0.1	-2.2	1.7	-1.6	1.5
Irritable Bowel Disease (IBD)	1.9	4.6	17.1	-4.1	0.3	-1.3	0.7	-1.8
Ulcerative Colitis (UC)	1.9	3.7	14.9	-3.9	0.7	-1.5	-0.0	-0.8
Crohns Disease (2012)	1.9	3.1	5.8	-2.1	0.0	-1.3	1.8	-2.4
BMI	1.9	11.2	25.0	3.2	0.8	-3.3	5.0	-3.0
Height	1.9	35.7	84.3	-5.0	-1.6	6.4	-9.2	5.0
High blood pressure (mother)	1.9	2.7	10.3	-0.3	3.2	-0.4	1.1	-1.4
Fluid intelligence score	1.9	4.0	7.8	0.9	-0.7	-2.6	2.8	-2.1
Had major operations	1.9	2.3	6.9	0.5	2.6	1.4	-0.8	1.3
Fasting Glucose	1.8	2.1	5.5	1.3	-2.3	1.6	-0.4	0.8
Eye problems/disorders: None of the above	1.8	2.1	3.4	-0.9	-0.5	1.8	-1.6	1.9
Chest pain or discomfort	1.8	2.6	8.1	2.9	-1.8	0.1	1.0	-0.7
Family relationship satisfaction	1.8	2.2	6.1	2.5	-1.2	1.5	-0.9	0.5
Supplements: Vitamin C	1.8	2.1	5.1	-1.2	-2.3	-0.4	0.8	-1.8
Mean Putamen Volume	1.7	2.0	3.9	0.3	-0.5	-1.4	1.9	-2.0
Waist Hip Ratio (WHR)	1.7	7.7	19.0	0.5	0.2	2.8	-3.4	4.4
Medication for hormone replacement therapy	1.7	1.9	4.2	0.4	-2.0	-1.7	0.8	-1.3
Allergy	1.7	3.9	11.3	-1.3	1.6	-3.4	1.8	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	4.5	-1.5	0.7	-1.4	0.8	-2.1
Commuting to job workplace: Cycle	1.7	2.0	3.4	-1.9	-1.6	1.5	-1.2	0.5
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	6.3	0.6	-2.5	0.1	-1.1	1.6
Ulcerative Colitis	1.6	2.3	10.5	-3.2	0.2	-0.8	-0.5	-0.2
Had menopause	1.6	2.1	3.5	1.1	-1.8	-0.4	1.4	-1.9
Father’s age at death	1.6	2.2	3.9	-0.0	-1.8	-2.0	1.3	-1.4
Comparative body size at age 10	1.6	4.3	6.8	-0.8	-1.6	-2.5	2.6	-2.3
Mean time to correctly identify matches	1.6	3.1	12.4	-3.5	1.2	-0.8	-0.3	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.1	1.5	1.4	-0.5	2.0	-1.1
Arm fat percentage (left)	1.6	6.4	13.5	2.2	2.3	-2.3	3.7	-1.7
Eye problems/disorders: Glaucoma	1.6	1.8	4.0	0.8	1.1	-1.2	1.4	-2.0
Reaction Time	1.5	2.9	10.4	-3.2	1.8	-0.5	-0.7	-0.2
Ever had hysterectomy (womb removed)	1.5	1.7	3.8	1.2	0.4	-0.6	1.7	-2.0
Vitamin and mineral supplements	1.5	2.1	4.8	1.7	-0.3	0.9	-1.3	2.2
Illnesses of mother	1.5	1.9	4.7	2.2	-1.9	0.8	-0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	5.5	1.3	-2.4	0.1	0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	4.3	2.1	-1.1	1.2	-1.3	0.6
Back pain experienced in last month	1.5	2.2	5.3	0.9	-2.3	-1.4	1.2	-1.0
Mineral and other dietary supplements	1.5	2.0	5.8	2.4	-0.7	0.1	-0.7	1.7
Bipolar Disorder (2018)	1.4	2.2	3.8	-1.9	0.8	-1.7	1.0	-1.8
Intelligence (Savage-Jansen 2018)	1.4	4.3	8.7	1.3	-1.7	-3.0	2.2	-1.8
Major Depression (MDD)	1.4	1.7	2.6	1.3	1.3	0.5	-1.4	1.6
Breast Cancer	1.4	3.3	11.1	1.6	-3.3	-0.4	1.0	-1.3
Schizophrenia (2014)	1.4	3.1	8.5	-1.8	2.9	0.9	-1.6	0.6
Body mass index (BMI)	1.4	5.8	12.4	2.3	1.2	-2.2	3.5	-2.2
Forced vital capacity (FVC), Best measure	1.4	5.2	7.7	-1.4	-1.8	2.4	-2.7	2.8
Health satisfaction	1.4	1.8	7.3	2.7	-0.4	0.3	-0.4	1.1
Angina (self-reported)	1.4	1.8	4.6	-0.5	-0.1	-2.1	2.0	-0.6
Comparative height size at age 10	1.4	7.9	19.5	-4.4	0.6	1.9	-3.7	1.4
Medication for cholesterol	1.4	2.2	3.4	-1.9	1.4	1.0	-1.4	1.6
Medication: Gliclazide	1.4	1.6	3.1	0.0	1.8	0.8	-1.2	1.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	6.4	-1.1	0.9	-0.3	0.7	-2.5
LDL Cholesterol	1.3	2.0	3.7	0.8	-1.9	1.2	-1.2	1.6
Supplements: Glucosamine	1.3	1.6	3.6	-1.8	0.4	0.0	1.0	-1.9
Arm fat percentage (right)	1.3	5.2	10.8	1.9	2.5	-2.1	3.3	-1.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.5	-0.2	-0.7	0.6	-1.9	1.8
Age at first live birth	1.3	2.3	6.6	-2.6	-0.9	-0.4	-1.3	1.4
Impedance of whole body	1.3	6.5	18.7	0.5	1.3	2.4	-2.5	4.3
Medication: Levothyroxine sodium	1.2	2.0	3.3	0.7	0.8	-1.8	1.6	-1.7
Hair/balding pattern: Pattern 2	1.2	1.5	2.6	-1.1	1.0	1.6	-1.3	1.0
Impedance of arm (right)	1.2	5.5	12.2	-1.2	3.1	1.1	-1.8	3.5
Qualifications: A levels/AS levels or equivalent	1.2	2.7	8.7	2.1	-2.9	0.4	-0.4	-0.0
Asthma	1.2	2.4	6.1	1.6	-1.7	2.5	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	4.0	6.0	-1.4	-1.2	2.2	-2.4	2.5
Pulse wave Arterial Stiffness index	1.2	1.4	4.3	-2.1	0.7	0.7	-1.2	0.7
Standing height	1.2	12.4	27.4	-4.1	-0.7	3.5	-5.2	2.3
Blood clot in the leg (DVT)	1.2	1.5	4.4	-2.1	1.7	0.5	-0.1	-0.2
Illnesses of siblings: Diabetes	1.2	1.5	4.5	-1.1	0.5	0.2	-1.3	2.1
Eye problems/disorders: Cataract	1.2	1.4	2.5	-1.1	0.9	-1.2	1.0	-1.6
Hearing aid user	1.2	1.4	2.7	0.7	-0.3	1.1	-1.7	1.6
High cholesterol (Self-reported)	1.2	2.2	5.1	2.3	-1.7	0.7	-0.9	1.3
Average weekly beer plus cider intake	1.2	1.7	2.8	1.6	0.9	1.7	-0.7	1.3
Alzheimer’s Disease (including proxy)	1.1	1.5	3.8	-0.8	0.2	1.2	-1.9	1.3
Crohns Disease (2017)	1.1	2.3	4.8	-2.1	0.1	-0.6	1.4	-2.2
Allergy or Eczema	1.1	2.9	8.4	-0.0	-0.4	2.9	-2.1	1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	4.9	0.5	2.2	1.0	-0.5	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.0	-0.7	1.0	1.9	-2.0	1.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	5.2	2.3	0.8	-0.5	0.6	-0.9
Number of full brothers	1.1	1.4	3.0	0.8	0.5	-0.9	1.5	-1.7
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.3	1.4	-0.7	-0.4	1.5	-1.2
Qualifications: nursing, teaching	1.1	1.7	3.1	1.8	0.2	1.1	-1.6	1.3
Asthma (self-reported)	1.1	2.3	5.9	1.7	-1.3	2.4	-0.5	0.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.6	0.6	-1.0	1.9	-1.1	0.8
Fractured/broken bones in last 5 years	1.1	1.4	2.1	-0.9	-0.5	1.4	-1.4	1.3
Alzheimer’s Disease (in mother)	1.0	1.2	2.6	-1.6	-0.0	0.6	-1.4	0.9
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.6	1.2	-1.2	-2.1	1.6	-1.4
Cardiovascular Disease	1.0	3.2	12.2	3.5	0.2	-1.1	1.3	-0.8
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.7	0.9	-1.3	-1.0	1.1	-1.0
Taking other prescription medications	1.0	1.6	4.4	2.1	-1.7	-0.4	0.4	0.5
Serious illness, injury or assault to yourself	1.0	1.2	5.1	-2.3	-0.6	0.5	0.0	0.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.9	-2.0	0.1	-0.7	0.6	-1.1
Forced vital capacity (FVC)	1.0	3.9	9.0	-0.9	-3.0	2.0	-1.6	1.7
Medication: Ramipril	1.0	1.2	1.5	1.0	-1.1	1.2	-1.1	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.5	-0.1	0.0	-1.3	1.9	-1.6
Pulse wave reflection index	1.0	1.3	4.4	-2.1	1.0	0.3	-0.9	-0.2
Medication: Paracetamol	1.0	1.7	4.2	0.0	0.3	1.6	-1.3	2.0
Body fat percentage	1.0	3.8	6.9	2.6	2.0	-1.1	2.6	-0.4
Shortness of breath walking on level ground	1.0	1.2	2.7	0.5	0.9	0.5	-1.4	1.6
Medication: Omeprazole	1.0	1.2	4.0	0.8	-2.0	0.1	-0.8	0.8
Age at last live birth	1.0	1.4	2.9	-1.7	-0.8	0.5	-1.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.4	-0.7	-0.7	0.1	-1.3	1.5
Osteoarthritis (self-reported)	1.0	1.3	2.2	1.5	-1.4	1.3	-0.7	0.2
Arm fat mass (left)	1.0	4.0	8.0	1.6	1.6	-1.8	2.8	-1.8
Medication: Blood pressure	1.0	1.9	3.6	1.9	-0.8	-0.6	1.6	-1.5
Ever depressed for a whole week	1.0	1.2	3.2	0.4	-0.1	1.1	-1.1	1.8
Schizophrenia (2018)	0.9	1.8	6.4	-0.5	2.5	1.1	-1.1	0.3
Body Mass Index (BMI) (2010)	0.9	1.3	3.0	0.1	1.7	-0.8	1.4	-0.9
Neuroticism (2016)	0.9	1.3	4.4	0.8	2.1	0.6	-0.4	0.9
Lung FVC	0.9	4.4	17.4	-0.8	-4.2	1.1	-0.0	1.6
Angina	0.9	1.2	2.9	-0.0	0.3	-1.7	1.7	-0.4
Townsend deprivation index at recruitment	0.9	1.2	2.4	-1.3	1.0	-0.8	0.7	-1.5
Mouth/teeth dental problems	0.9	1.4	6.3	-2.5	-0.3	-0.4	0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	5.0	-0.8	-2.2	2.0	-1.6	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.4	1.5	1.0	-0.8	1.1	-0.4
Arm fat mass (right)	0.9	3.6	7.2	1.4	1.7	-1.8	2.7	-1.5
Pulse wave peak to peak time	0.9	1.1	2.8	1.7	-0.8	-0.6	1.0	-0.8
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.2	-1.4	-0.5	-1.5	1.0	-0.5
Alcohol drinker status: Never	0.9	1.1	3.8	-0.0	-0.3	-1.9	0.8	-1.0
Leg fat percentage (left)	0.9	3.3	8.7	3.0	0.9	-0.9	2.4	-0.3
Supplements: Calcium	0.9	1.0	2.3	-1.5	0.2	-0.1	0.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.6	-1.9	1.3	0.4	-0.2	-0.2
Alcohol drinker status: Previous	0.9	1.1	3.3	0.6	0.5	0.3	1.1	-1.8
Bipolar Disorder or Schizophrenia	0.8	1.8	5.9	-1.6	2.4	-0.2	-0.3	-0.9
Heel T-Score	0.8	6.3	9.2	1.7	-1.6	2.9	-3.0	2.9
Diabetes (father)	0.8	0.9	3.5	-1.9	-0.2	-1.0	-0.1	-0.3
Trunk fat percentage	0.8	3.4	5.8	2.4	2.2	-1.1	2.3	-0.1
Sitting height	0.8	5.8	8.7	-3.0	-2.7	-1.8	1.3	-2.9
Number of incorrect matches in round	0.8	1.3	5.4	-2.3	0.0	0.8	-0.5	0.4
Falls in the last year	0.8	1.0	3.3	0.6	0.0	1.8	-0.8	0.9
Impedance of arm (left)	0.8	3.5	8.2	-0.4	2.5	1.0	-1.4	2.9
Worry too long after embarrassment	0.8	1.4	5.3	0.5	0.5	2.3	-0.6	1.0
Chronotype (morning person)	0.7	1.7	3.4	1.2	1.9	0.6	-0.4	1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	0.1	-0.0	-0.8	1.0	-1.4
High blood pressure	0.7	1.9	4.6	2.2	-0.5	-0.9	1.3	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	0.1	-0.1	1.1	-0.9	1.5
Leg fat percentage (right)	0.7	2.7	7.1	2.7	0.8	-0.7	2.2	0.1
Wheeze or whistling in the chest in last year	0.7	1.2	3.1	1.2	-0.9	1.8	0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	-0.8	0.6	0.3	-1.1	1.4
Average weekly red wine intake	0.7	1.1	2.9	0.2	-1.7	-0.2	-1.5	0.4
Medication: Aspirin	0.7	0.9	3.0	-0.3	0.1	-1.7	1.2	-0.0
Wears glasses or contact lenses	0.7	0.8	2.7	-0.0	0.4	-1.6	0.8	-0.8
Ever taken oral contraceptive pill	0.7	0.8	1.6	-1.3	0.5	-0.3	-0.8	1.2
Age started oral contraceptive pill	0.7	0.9	3.2	-0.8	1.8	-0.3	-0.4	-0.4
Ovarian Cancer	0.6	0.8	1.3	0.4	-0.9	-1.1	0.6	-1.2
Bipolar Disorder (2011)	0.6	0.6	1.4	-1.2	-0.5	-0.9	-0.4	-0.4
HDL Cholesterol	0.6	0.9	1.9	0.3	1.2	0.6	-1.0	1.4
Rheumatoid Arthritis	0.6	0.9	3.1	-1.8	0.5	-0.4	0.8	-0.5
Hearing difficulty/problems: Yes	0.6	0.9	2.0	0.1	0.5	1.1	-1.4	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.8	1.3	-1.1	-0.6	0.7	-0.5
Diabetes (mother)	0.6	0.8	2.9	0.4	1.7	0.1	0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.5	-0.8	0.7	1.6	-1.2	1.3
Hip circumference	0.6	2.4	5.3	-0.1	1.0	-1.9	2.3	-1.5
Medication: Cholesterol lowering	0.6	1.0	1.9	1.4	-1.2	0.1	-0.5	1.2
Exposure to tobacco smoke at home	0.6	0.7	1.4	-0.4	-1.0	-0.7	0.6	-1.2
Hair/balding pattern: Pattern 4	0.6	1.4	3.6	-1.1	0.2	-1.9	1.2	-0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	-0.6	1.0	0.5	-0.4	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.9	2.0	-0.6	0.1	0.6	-0.6
Emphysema/chronic bronchitis	0.6	0.6	2.1	0.1	-0.2	-1.0	0.3	-1.5
Migraine (self-reported)	0.6	0.7	1.3	-0.4	-1.0	-0.5	1.0	-1.1
Medication: Ibuprofen	0.6	0.7	1.6	0.9	1.3	-0.6	0.5	-0.5
Knee pain experienced in last month	0.6	1.0	2.5	-0.0	1.6	1.5	-0.5	0.1
Illnesses of father: Heart disease	0.6	0.8	1.4	-1.0	0.9	-1.2	0.7	-0.7
Osteoporosis (self-reported)	0.6	0.7	2.0	-1.2	-0.2	-1.4	0.2	-0.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.0	1.4	-0.8	1.4	-0.6	0.2
Average weekly champagne plus white wine intake	0.6	0.8	1.9	-1.0	-0.9	-1.4	-0.4	-0.1
Medication: Paracetamol	0.6	1.0	1.4	-0.4	1.1	1.0	-1.0	1.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.2	-1.8	-0.1	1.2	-1.5	1.1
Heart disease (siblings)	0.6	0.7	1.6	-1.3	1.2	0.5	-0.1	0.3
Leg fat mass (left)	0.6	2.5	5.6	1.9	1.0	-1.2	2.4	-1.1
Smoking Status	0.5	1.2	2.6	-0.4	-1.6	1.4	-1.0	0.7
Hand grip strength (right)	0.5	1.3	2.4	-0.5	-0.3	-1.4	1.3	-1.5
Average weekly fortified wine intake	0.5	0.6	1.3	-0.8	0.0	-0.9	0.4	-1.2
Trunk fat mass	0.5	2.0	3.7	1.6	1.6	-1.0	1.9	-0.6
Nervous feelings	0.5	0.9	3.5	-0.7	1.9	0.4	0.7	-0.1
Time employed in main current job	0.5	0.6	1.0	-0.7	1.0	-0.7	0.9	-0.3
Noisy workplace	0.5	0.6	2.3	-1.5	0.8	0.0	0.2	0.2
Tense / ‘highly strung’	0.5	0.8	3.1	-1.8	1.0	-0.1	0.1	0.1
Headache pain in last month	0.5	0.9	3.9	-0.3	2.0	0.2	-0.2	-0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.8	0.3	1.1	-1.4	1.2	-0.8
Whole body fat mass	0.5	2.3	4.9	1.6	1.4	-1.2	2.2	-0.8
Leg fat mass (right)	0.5	2.1	5.1	1.5	0.9	-1.2	2.2	-0.8
Medication: Aspirin	0.5	0.6	2.2	-0.2	-0.1	-1.5	0.9	0.3
Hypertension (Self-reported)	0.5	1.5	5.1	2.2	-0.2	-0.2	0.9	-1.2
Leg fat-free mass (right)	0.5	2.5	6.8	-1.9	0.4	-1.1	0.7	-2.6
Loneliness, isolation	0.5	0.7	2.0	-0.1	-1.4	0.4	-0.6	1.1
Leg predicted mass (right)	0.5	2.5	7.0	-1.9	0.4	-1.0	0.7	-2.6
Miserableness	0.5	0.9	2.2	0.8	1.3	1.5	0.1	-0.0
Guilty feelings	0.5	0.7	1.2	-1.1	-0.1	-0.8	1.0	-0.9
Financial situation satisfaction	0.5	0.7	1.3	0.6	1.1	-0.9	1.0	-0.2
Medication: Atorvastatin	0.5	0.6	1.3	0.2	-1.2	-0.7	0.0	1.1
Myopia	0.5	0.7	1.3	-1.1	1.2	-0.0	0.2	-0.8
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	-0.5	-0.2	1.6	-0.7	0.9
Neuroticism (Nagel 2018)	0.4	1.0	2.6	-0.2	-0.5	1.6	-0.4	1.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.0	0.6	0.9	-0.8	1.0
Alzheimer’s Disease (in father)	0.4	0.4	1.2	1.1	-0.3	0.0	-0.6	0.6
Age at First Birth	0.4	0.5	1.4	-1.2	-1.0	-0.2	0.1	0.3
Lupus	0.4	0.5	2.1	-1.4	-0.2	-0.5	0.6	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	-0.3	-0.6	-0.5	0.9	-0.8
Hand grip strength (left)	0.4	1.0	1.9	-0.8	0.9	-0.7	0.9	-1.4
Leg fat-free mass (left)	0.4	1.9	5.4	-1.7	0.3	-1.0	0.7	-2.3
Current tobacco smoking	0.4	0.7	1.9	-1.2	-1.4	-0.0	-0.5	0.4
Leg predicted mass (left)	0.4	2.0	5.5	-1.7	0.4	-0.9	0.7	-2.3
Past tobacco smoking	0.4	0.7	2.4	-1.6	0.6	-0.2	-0.7	0.5
Had other major operations	0.4	0.5	1.4	-1.2	0.6	-0.4	-0.4	0.6
Qualifications: None of the above	0.4	0.8	1.2	-0.9	1.0	0.4	-1.0	1.1
Diabetes (self-reported)	0.4	0.6	1.1	-0.2	0.8	0.9	-1.0	0.8
Medication: Simvastatin	0.4	0.5	2.4	1.6	-0.1	-0.3	-0.3	0.2
Happiness	0.4	0.5	2.0	1.4	0.1	0.8	-0.1	0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	0.7	1.4	0.5	-0.2	-0.7
Peak expiratory flow (PEF)	0.4	0.9	2.8	0.8	-1.7	0.6	-0.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.3	-1.1	0.0	0.0	0.7	-1.1
Glaucoma (self-reported)	0.4	0.4	1.4	-0.4	1.2	-0.4	-0.1	-0.7
Pulse rate, automated reading	0.4	1.3	3.9	1.2	-2.0	-0.1	1.0	-0.3
Alcohol intake frequency.	0.4	0.9	1.5	1.0	1.2	1.2	0.1	0.8
Smoking status: Previous	0.4	0.7	1.2	1.1	-0.7	-0.1	1.1	-0.7
Breast cancer (self-reported)	0.4	0.5	1.7	-0.0	-0.5	0.4	-0.6	1.3
Smoking status: Current	0.4	0.7	1.8	-1.1	-1.3	0.1	-0.7	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	-0.9	0.1	-0.5	1.0	-0.5
Illnesses of father: High blood pressure	0.4	0.5	1.8	1.4	0.6	-0.2	0.0	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.9	0.3	0.3	0.5	0.3	-1.4
Diastolic blood pressure, automated reading	0.4	1.4	4.4	0.7	-0.8	-0.6	2.1	-1.0
Unable to work because of sickness or disability	0.4	0.5	1.4	-0.4	-0.8	0.0	0.6	-1.2
Depression (Nagel 2018)	0.3	0.4	0.9	0.0	-0.4	0.8	-0.6	1.0
Coronary Artery Disease (CAD)	0.3	0.4	0.6	-0.2	0.7	-0.6	0.5	-0.8
HbA1C	0.3	0.3	0.5	0.5	-0.7	0.6	0.4	-0.7
Blood Eosinophil Count	0.3	2.0	7.2	2.7	0.4	1.4	-0.4	-0.4
Systolic Blood Pressure	0.3	1.4	4.1	0.3	-0.4	-2.0	1.4	-0.9
Respiratory disease	0.3	0.7	1.8	1.2	-0.3	1.3	0.1	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	-0.2	0.5	0.7	-1.0	0.8
Lung FEV1/FVC ratio	0.3	1.3	3.5	-0.9	0.5	-0.3	1.3	-1.9
Neuroticism	0.3	0.6	1.8	-0.5	-0.0	1.4	-0.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.4	-0.6	1.2	-0.1	-0.4	0.5
Medication: Metformin	0.3	0.4	0.7	-0.7	0.8	-0.0	-0.7	0.6
Fed-up feelings	0.3	0.5	1.3	-0.5	-0.1	-0.1	1.1	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	1.0	0.2	0.8	0.7	-0.1
Age when periods started (menarche)	0.3	0.8	2.4	-1.6	-0.4	-1.1	0.4	0.2
Stomach or abdominal pain in last month	0.3	0.3	1.1	-0.1	-1.0	0.2	-0.1	0.8
Waist circumference	0.3	0.9	1.8	1.1	1.3	-0.6	1.1	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-1.0	1.1	-0.3	0.3	-0.1
Hearing difficulty/problems with background noise	0.3	0.4	1.1	0.2	-0.4	0.6	-1.1	0.7
Heart attack	0.3	0.3	0.6	-0.1	-0.5	-0.6	0.8	0.7
Pain all over the body in last month	0.3	0.4	0.7	-0.8	-0.8	0.6	-0.1	0.5
Illnesses of siblings	0.3	0.4	1.6	0.2	-1.3	0.3	0.0	0.1
Trunk fat-free mass	0.3	1.9	4.3	-2.1	-1.3	0.6	-1.4	-1.1
Worrier / anxious feelings	0.3	0.5	1.7	0.1	0.8	0.4	1.3	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.7	-0.9	-0.2	0.9	0.6	-0.9
Pulse rate	0.3	0.5	1.6	0.6	-1.3	-0.6	0.3	0.5
Depression (self-reported)	0.3	0.4	1.4	1.2	0.0	-0.8	0.2	0.2
Medication: Lansoprazole	0.3	0.3	1.3	-1.2	-0.2	-0.2	0.3	0.4
Trunk predicted mass	0.3	1.9	4.3	-2.1	-1.3	0.7	-1.5	-1.0
Breastfed as a baby	0.3	0.4	1.2	0.4	-0.2	0.5	-0.6	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	0.5	0.1	1.0	-0.3	0.5
Arm fat-free mass (right)	0.3	1.3	3.1	-0.6	-1.8	0.4	-0.5	-1.7
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.5	0.7	0.8	-0.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.8	-0.0	0.2	0.0	0.9	-0.9
Arm predicted mass (right)	0.3	1.4	3.2	-0.7	-1.8	0.4	-0.4	-1.8
Overall health rating	0.3	0.6	1.4	0.6	0.1	-0.2	1.1	-1.2
Whole body fat-free mass	0.3	1.5	3.6	-1.9	-0.7	0.1	-0.6	-1.7
Long-standing illness, disability or infirmity	0.3	0.4	0.6	0.1	0.8	-0.7	0.7	-0.6
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.1	0.7	0.7	-1.0	0.8
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.4	0.7	-0.3	-0.8	0.4
Whole body water mass	0.3	1.5	3.4	-1.9	-0.7	0.1	-0.5	-1.9
Irritability	0.3	0.5	1.4	1.2	-0.7	0.6	0.2	0.5
Cholesterol lowering medication	0.3	0.4	1.0	1.0	-0.6	-0.6	0.4	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.1	0.9	0.7	-0.7	-0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	0.1	-0.5	-0.7	1.0	0.3
Worry (Nagel 2018)	0.2	0.4	1.0	-0.9	0.1	-0.5	1.0	-0.1
Triglycerides	0.2	0.3	1.0	0.2	0.3	1.0	-0.5	0.5
Hypothyroidism (self reported)	0.2	0.6	1.0	0.9	0.6	-1.0	0.8	-0.0
Tanning	0.2	2.7	4.7	-2.2	-0.1	1.9	-2.0	0.9
Number of treatments/medications taken	0.2	0.4	0.8	0.3	-0.2	-0.9	0.7	-0.6
Average weekly spirits intake	0.2	0.3	1.2	0.3	0.2	-0.4	0.1	-1.1
Systolic blood pressure, automated reading	0.2	0.6	1.0	-0.6	0.3	-0.9	1.0	-0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.8	-0.2	-0.5	0.6	-0.1
Medication: Atenolol	0.2	0.2	0.7	-0.3	-0.8	-0.3	-0.1	0.4
Financial difficulties in last 2 years	0.2	0.3	1.0	0.3	-0.0	-0.4	1.0	-0.6
Neuroticism score	0.2	0.5	1.4	-0.3	1.2	0.8	0.5	0.3
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.1	1.0	0.6	0.4	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.0	0.7	-0.8	0.6	-0.5
Number of live births	0.2	0.3	0.7	-0.6	0.8	-0.2	0.6	-0.5
Prospective memory result	0.2	0.2	0.5	-0.6	-0.1	0.0	0.5	-0.7
Gout (self-reported)	0.2	0.3	0.7	0.5	0.8	-0.0	0.8	-0.2
High blood pressure (siblings)	0.2	0.3	0.6	0.4	0.4	-0.7	0.5	-0.8
Number of children fathered	0.2	0.2	0.7	0.6	-0.3	0.0	0.2	-0.8
Qualifications: College or University degree	0.2	0.5	0.9	0.8	-0.1	0.9	-0.9	0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.6	-0.8	-0.6	0.8	-0.4	-0.4
Medication: Allopurinol	0.2	0.2	0.7	0.3	0.8	-0.2	0.6	-0.3
Suffer from ‘nerves’	0.2	0.3	0.9	0.1	1.0	-0.0	0.3	-0.7
Mood swings	0.2	0.3	0.8	0.2	0.8	0.9	-0.0	-0.1
Ever had bowel cancer screening	0.2	0.3	0.5	0.6	-0.2	0.7	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	0.4	-1.2	0.5	0.1	0.3
Mother’s age at death	0.2	0.3	1.3	-1.1	0.1	-0.0	-0.3	-0.2
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.5	-0.5	0.5	-0.8	0.4
Basal metabolic rate	0.2	0.9	2.5	-1.4	-0.3	-0.0	-0.2	-1.6
Arm fat-free mass (left)	0.2	0.9	1.5	-0.8	-1.0	0.6	-0.8	-1.2
Number of operations (self-reported)	0.2	0.3	0.8	0.4	0.9	0.5	0.4	-0.3
Pain experienced in last month	0.2	0.3	0.7	-0.6	0.5	-0.9	0.5	-0.1
Arm predicted mass (left)	0.2	0.9	1.6	-0.8	-1.1	0.6	-0.7	-1.2
Blood Platelet Count	0.1	0.8	1.8	-1.2	-0.4	-0.5	-0.6	1.4
Blood Red Count	0.1	0.6	1.4	0.4	-1.2	0.8	0.8	-0.0
Blood White Count	0.1	1.0	3.3	0.3	0.4	1.8	-0.7	1.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.3	0.5	0.1	0.3	0.4
Relative age of first facial hair	0.1	0.2	0.6	-0.3	-0.8	-0.3	-0.3	-0.1
Supplements: Zinc	0.1	0.1	0.3	0.2	0.2	0.1	0.2	-0.5
Pack years adult smoking proportion	0.1	0.2	0.5	-0.4	0.1	0.1	-0.5	0.7
Relative age voice broke	0.1	0.2	0.6	0.4	-0.8	0.0	0.1	0.1
Alcohol usually taken with meals	0.1	0.2	0.7	-0.2	0.4	-0.1	-0.8	0.4
Weight	0.1	0.6	1.2	0.2	0.8	-0.5	1.0	-1.1
Lung cancer (father)	0.1	0.2	0.5	-0.2	-0.2	-0.7	0.4	-0.0
Medication: Amlodipine	0.1	0.2	0.6	0.5	-0.8	0.2	-0.1	0.3
Medication: Blood pressure	0.1	0.2	0.5	0.6	-0.3	-0.3	-0.2	0.7
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	-0.7	-0.3	0.2	0.3	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.5	0.1	0.0	-0.1	0.1	-0.7
Ever smoked	0.1	0.1	0.3	0.6	0.0	0.4	0.1	0.0
Pack years of smoking	0.1	0.2	0.6	-0.4	-0.1	-0.1	-0.5	0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.6	0.9	-0.9	-0.5	-0.7	0.9	-0.7

Hub : Genes

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Trait associations