TWAS hub - TNFSF13B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pituitary	0.4220	0.1410	0.00960	0.036	NA	-0.002	NA	0.050	4.5e-02	NA	3.8e-01	NA	2.2e-02
2	TCGA	Bladder Urothelial Carcinoma	0.0690	0.0340	0.00780	-0.003	0.009	-0.003	NA	-0.003	7.8e-01	5.1e-02	6.5e-01	NA	7.0e-01
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0517	0.0209	0.00031	0.047	0.044	0.035	NA	0.034	5.0e-06	9.3e-06	8.3e-05	NA	8.5e-05
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0338	0.0148	0.00190	0.024	0.015	0.021	NA	0.025	8.9e-04	7.9e-03	1.9e-03	NA	7.8e-04
5	TCGA	Lung Adenocarcinoma	0.0478	0.0224	0.00380	0.020	0.019	0.002	NA	0.015	1.7e-03	2.4e-03	2.0e-01	NA	6.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Number of full sisters	3.8	4.6	6.6	2.2	-2.6	-1.6	-2.4	-1.8
Had major operations	3.5	4.1	6.7	0.8	-2.6	-1.0	-2.3	-2.6
Number of full brothers	3.2	4.1	7.8	-1.4	-1.5	-1.5	-2.8	-2.5
Mineral and other dietary supplements	3.0	4.0	11.9	-3.5	-1.1	-0.6	-1.4	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	6.3	-0.2	1.1	2.5	2.5	1.9
Fractured/broken bones in last 5 years	2.7	3.5	10.8	1.2	-3.3	-1.4	-1.7	-0.8
Medication: Ventolin 100micrograms inhaler	2.5	3.2	6.8	-0.2	-0.3	-2.0	-2.3	-2.6
Pulse wave reflection index	2.4	3.0	4.4	-0.6	-1.8	2.1	2.0	1.7
Allergy or Eczema	2.3	6.1	8.1	-2.2	-1.9	-2.9	-2.7	-2.6
Hayfever, allergic rhinitis or eczema	2.3	5.0	8.0	-1.6	-1.1	-2.8	-2.7	-2.5
Average weekly fortified wine intake	2.2	2.6	5.8	-2.4	2.0	-0.6	0.7	1.5
Number of live births	2.2	3.1	6.6	0.3	-2.6	0.1	-2.3	-1.9
Illnesses of mother	2.2	2.7	6.2	-0.6	1.0	1.7	1.8	2.5
Illnesses of siblings: Diabetes	2.1	2.6	4.8	1.7	-0.2	-2.2	-1.8	-1.3
Osteoarthritis (self-reported)	2.1	2.8	7.3	2.1	2.7	-0.8	-0.2	1.1
Pulse wave peak to peak time	2.0	2.3	4.2	-0.9	1.0	-1.8	-1.5	-2.1
Angina (self-reported)	2.0	2.6	4.1	0.8	1.5	1.7	1.7	2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.0	-1.2	-0.0	-1.7	-2.0	-1.5
Ulcerative Colitis (UC)	1.9	3.5	6.3	-0.6	-0.3	-2.5	-2.3	-2.4
Pulse wave Arterial Stiffness index	1.9	2.2	4.4	0.9	-0.7	1.7	1.5	2.1
Lupus	1.8	2.7	6.6	-0.4	0.9	1.8	2.6	1.7
Triglycerides	1.8	3.0	5.7	1.5	-1.2	-1.4	-2.0	-2.4
Angina	1.8	2.4	3.6	0.9	1.6	1.5	1.6	1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	9.2	-3.0	-0.5	-0.6	0.0	0.9
LDL Cholesterol	1.7	2.6	5.1	1.1	-0.7	-1.8	-1.8	-2.3
Ulcerative Colitis	1.7	2.4	4.0	-1.4	0.3	-2.0	-1.5	-1.9
Allergy	1.7	4.0	6.5	1.4	1.0	2.3	2.5	2.3
Blood White Count	1.6	11.6	24.9	0.9	-5.0	-4.4	-3.5	-0.9
Depression (self-reported)	1.6	1.9	3.9	-1.3	1.2	0.9	1.3	2.0
Financial situation satisfaction	1.6	1.9	3.6	0.9	-1.0	-1.2	-1.9	-1.6
Body Mass Index (BMI) (2010)	1.5	2.0	3.4	1.8	-1.4	-1.2	-1.5	-1.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	5.7	-1.4	2.4	0.3	1.1	0.8
Medication: Ibuprofen	1.5	1.8	4.3	-0.2	-0.5	-1.5	-1.5	-2.1
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.5	2.1	-0.1	1.3	1.2	1.2
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.7	-0.3	-0.9	-0.8	-2.2	-1.8
Worry (Nagel 2018)	1.4	3.0	6.0	-0.3	0.6	2.4	2.0	2.2
Major Depression (MDD)	1.4	1.7	3.7	-0.9	1.3	0.9	1.3	1.9
Hearing difficulty/problems: Yes	1.4	2.1	4.0	0.8	0.2	2.0	2.0	1.4
Severe depression (siblings)	1.4	1.6	2.7	-0.6	1.5	0.5	1.5	1.6
Townsend deprivation index at recruitment	1.4	1.9	3.4	0.7	0.7	1.6	1.7	1.8
Prospective memory result	1.4	1.7	3.0	-0.3	0.8	1.7	1.7	1.5
Blood clot in the leg (DVT)	1.4	1.9	4.2	-0.4	-1.0	-0.9	-2.0	-1.8
Suffer from ‘nerves’	1.4	2.2	5.5	0.3	1.4	1.3	1.2	2.4
Back pain experienced in last month	1.4	2.0	7.2	2.7	-0.1	-0.6	-1.4	-0.8
Pain type(s) experienced in last month: Hip pain	1.4	1.7	5.1	0.7	2.3	0.6	1.2	1.2
Alcohol drinker status: Previous	1.4	1.6	5.6	0.5	0.1	2.4	1.3	0.6
Blood Platelet Count	1.3	14.9	32.3	0.7	-5.7	-4.8	-4.2	-1.1
Number of treatments/medications taken	1.3	2.4	4.4	1.8	0.5	-2.1	-1.3	-1.5
Stomach or abdominal pain in last month	1.3	1.6	2.5	1.1	1.4	-1.6	-0.9	-1.3
Number of incorrect matches in round	1.3	2.2	5.1	-1.2	-2.2	-1.6	-1.0	-1.1
Diabetes (self-reported)	1.3	2.0	8.2	1.0	-2.9	0.0	-0.8	-0.3
Illnesses of siblings	1.3	1.8	3.4	-0.9	0.7	1.8	1.8	1.0
Qualifications: nursing, teaching	1.3	2.0	8.6	-2.9	-0.9	0.4	-0.3	-0.2
Eye problems/disorders: Cataract	1.3	1.5	7.3	-2.7	-0.1	-0.3	-0.3	-0.4
Commuting to job workplace: Public transport	1.3	1.5	3.2	-0.6	1.1	0.5	1.8	1.6
Pack years of smoking	1.3	1.9	4.8	2.2	-1.1	-1.6	-0.9	0.1
Coronary Artery Disease (CAD)	1.2	1.4	3.8	-0.9	-0.3	2.0	1.0	1.2
Crohns Disease (2012)	1.2	1.9	8.1	-2.9	-0.5	0.8	0.3	0.5
Relative age of first facial hair	1.2	2.4	4.9	0.1	2.2	1.1	1.7	1.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.2	1.8	-1.8	0.5	0.0	-0.0
Pack years adult smoking proportion	1.2	1.9	4.5	2.1	-0.8	-1.9	-1.0	0.0
High blood pressure (mother)	1.2	1.6	3.2	-0.5	-1.3	-0.7	-1.8	-1.6
Tense / ‘highly strung’	1.2	2.0	2.9	-1.6	-0.1	1.5	1.6	1.7
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.3	1.8	1.3	-1.1	0.5	0.6
Alcohol intake frequency.	1.2	2.9	6.9	-0.9	2.6	0.7	2.0	1.5
Medication: Blood pressure	1.2	2.3	4.6	-1.1	-0.5	-1.2	-1.9	-2.1
Medication: Lansoprazole	1.1	1.3	2.1	0.8	0.2	1.5	1.4	1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.8	0.9	0.4	1.9	1.3	0.2
Asthma (self-reported)	1.1	2.2	4.4	-0.2	-1.3	-1.6	-2.1	-1.4
Medication: Aspirin	1.1	1.4	3.4	-0.8	1.8	-1.6	0.4	0.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	6.8	-0.8	-2.6	-0.6	-1.2	-0.6
Fed-up feelings	1.0	1.8	3.2	0.2	-1.8	-0.8	-1.6	-1.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.3	0.8	1.2	-0.1	1.5	1.1
Hair/balding pattern: Pattern 2	1.0	1.2	1.9	-1.4	0.7	1.0	1.3	1.0
Heart disease (mother)	1.0	1.3	2.7	1.6	1.4	-1.1	-0.2	-0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.9	-1.2	1.7	-0.4	-0.4	-0.9
Long-standing illness, disability or infirmity	1.0	1.6	4.9	2.2	0.0	-1.5	-0.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.9	2.0	0.6	0.5	0.7	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.7	1.1	0.4	-1.9	-0.4	-0.7
Medication: Bendroflumethiazide	1.0	1.5	3.0	-1.7	1.0	-1.1	-0.1	-1.4
Ever depressed for a whole week	1.0	1.2	1.9	1.1	-1.3	-0.8	-0.8	-1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	5.0	-0.5	2.2	-0.5	0.5	0.9
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.5	1.9	-0.7	-0.3	-0.9	-0.6
Waist Hip Ratio (WHR)	0.9	3.9	7.5	1.5	-2.7	1.9	-1.1	-2.2
Cardiovascular Disease	0.9	3.1	6.3	-0.3	-1.7	-1.4	-2.1	-2.5
Neuroticism	0.9	2.1	4.8	-0.6	0.5	2.2	1.7	1.4
Hand grip strength (right)	0.9	2.4	3.3	1.3	0.8	1.8	1.7	1.8
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.4	-0.5	-1.2	-0.8	-0.9	-1.5
Heart attack	0.9	1.1	4.6	-0.4	2.1	-0.4	0.5	0.8
Hair/balding pattern: Pattern 3	0.9	1.3	4.3	0.2	-2.1	-0.7	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.3	1.0	1.4	0.2	0.9	1.8
Medication: Amlodipine	0.9	1.3	3.6	-1.4	0.4	-0.7	-0.6	-1.9
Number of children fathered	0.9	1.0	2.3	-1.1	-0.1	1.5	0.4	-1.1
Migraine (self-reported)	0.9	1.1	2.5	-0.5	-0.1	-1.6	-0.9	-1.4
Overall health rating	0.9	1.9	4.1	2.0	-0.4	-1.8	-1.4	-0.2
Hypertension (Self-reported)	0.9	2.6	6.6	-1.1	-0.9	-0.7	-1.9	-2.6
Medication for cholesterol	0.9	1.3	2.4	0.3	1.3	1.2	1.5	1.0
Breast cancer (self-reported)	0.9	1.1	3.6	0.1	1.9	-0.4	0.2	1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.1	5.1	2.3	0.4	-0.2	0.4	0.5
Alcohol drinker status: Never	0.9	1.1	3.1	-1.7	1.4	-0.6	0.0	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	3.0	1.7	-1.1	0.6	-0.6	-0.6
Pain experienced in last month	0.9	1.6	4.1	-2.0	-0.0	1.2	1.3	0.7
Bipolar Disorder (2018)	0.8	1.2	2.5	-0.3	-0.8	-1.1	-1.6	-1.3
Primary Biliary Cirrhosis	0.8	1.2	3.1	-0.0	-1.8	1.7	-0.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.9	2.0	0.7	-0.3	0.8	0.4
Taking other prescription medications	0.8	1.2	3.1	1.8	1.2	-1.0	-0.2	0.7
Supplements: Glucosamine	0.8	1.0	3.3	1.8	-0.5	-1.2	-0.4	0.2
Medication: Simvastatin	0.8	1.2	2.5	0.9	1.6	0.8	1.2	0.8
Happiness	0.8	1.0	3.7	0.7	-1.9	0.1	-0.4	-0.9
Medication: Cholesterol lowering	0.8	1.2	3.4	0.1	1.9	-0.1	1.2	1.0
Length of working week for main job	0.8	0.9	2.1	0.1	-0.6	-1.4	-1.3	0.6
Birth weight of first child	0.8	1.5	5.1	-0.2	1.3	0.0	0.7	2.3
Medication: Paracetamol	0.8	1.4	4.2	1.5	2.1	-0.3	0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	4.7	2.2	-1.3	-0.3	-0.9	-0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	3.4	-1.6	-1.8	0.9	-0.5	-0.5
Wears glasses or contact lenses	0.8	0.9	3.1	1.7	-1.1	-0.0	-0.4	0.1
Myopia	0.8	1.1	3.9	0.2	0.6	0.5	1.0	2.0
Neuroticism (Nagel 2018)	0.7	1.7	3.1	-0.3	0.2	1.7	1.5	1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	1.9	-0.6	1.3	0.3	1.4	0.5
Alzheimer’s Disease (in father)	0.7	0.8	2.2	-1.5	0.5	-0.7	-0.8	-0.5
Irritable Bowel Disease (IBD)	0.7	1.8	3.1	-1.8	-0.1	-1.1	-1.3	-1.7
Fasting Glucose	0.7	0.9	2.3	-1.2	1.5	-0.6	0.5	-0.0
HDL Cholesterol	0.7	1.2	2.9	-0.9	0.3	0.4	1.4	1.7
High blood pressure	0.7	2.0	5.0	-1.1	-0.9	-0.5	-1.6	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.2	0.7	0.2	1.8	0.9	0.8
Hearing difficulty/problems with background noise	0.7	1.0	1.7	1.3	0.5	1.2	1.3	0.5
Had other major operations	0.7	0.9	2.1	0.1	1.2	-1.5	0.6	0.5
Asthma	0.7	1.4	3.0	-0.3	-1.1	-1.3	-1.7	-1.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.7	0.2	0.9	1.3	1.2	0.7
Worry too long after embarrassment	0.7	1.2	3.0	0.8	-1.7	-1.0	-1.2	0.2
Wheeze or whistling in the chest in last year	0.7	1.3	2.8	1.0	-0.5	-1.5	-1.7	-0.5
Qualifications: College or University degree	0.7	2.1	6.2	-2.5	0.6	0.3	1.6	1.2
Emphysema/chronic bronchitis	0.7	0.8	1.7	0.5	0.7	1.0	0.8	1.3
Leg pain on walking	0.7	0.8	1.9	0.4	-0.8	-1.4	-1.0	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.8	1.7	-0.0	-0.6	-0.8	-0.4
Medication: Aspirin	0.7	0.9	2.9	-0.3	1.7	-1.2	0.3	-0.1
Loneliness, isolation	0.7	0.9	2.7	-0.1	1.6	0.5	0.8	1.0
Ever had bowel cancer screening	0.7	0.8	1.7	-0.6	0.9	1.3	0.6	0.8
Diabetes diagnosed by doctor	0.7	1.1	3.6	1.1	-1.9	-0.1	-0.7	-0.4
Illnesses of father: None of the above (group 1)	0.7	0.8	2.3	0.7	1.5	0.3	0.4	1.0
High cholesterol (Self-reported)	0.7	1.3	4.6	0.4	2.1	-1.0	0.6	0.6
Medication: Paracetamol	0.7	1.1	3.8	0.5	1.9	-1.1	-0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.8	2.0	0.1	0.4	0.4	-0.1
Depressed Affect (Nagel 2018)	0.6	1.2	3.6	0.5	0.1	1.9	1.1	1.0
Age at First Birth	0.6	0.8	1.7	-1.1	0.8	0.5	1.3	0.7
Mean Putamen Volume	0.6	0.7	1.5	0.1	1.2	-0.1	0.9	1.1
Rheumatoid Arthritis	0.6	0.8	2.3	-1.5	-1.0	0.6	0.2	0.2
Blood Eosinophil Count	0.6	4.7	8.4	0.3	-2.9	-2.2	-2.6	-1.8
Respiratory disease	0.6	1.4	3.0	-0.1	-0.9	-1.5	-1.7	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.3	1.5	0.1	1.2	0.7	-0.1
Medication: Metformin	0.6	0.8	1.8	0.5	-0.9	1.3	0.7	0.8
Maternal smoking around birth	0.6	0.9	2.5	1.2	1.6	0.1	-0.4	0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.7	1.0	0.2	1.3	0.0	0.7
Chronic bronchitis/emphysema (father)	0.6	0.8	3.3	1.8	-0.1	-0.1	-0.7	-0.1
Alcohol usually taken with meals	0.6	0.9	1.5	-1.1	1.0	-0.2	1.2	0.9
Qualifications: None of the above	0.6	1.2	5.0	2.2	-0.2	0.8	0.1	-0.5
Mouth/teeth dental problems	0.6	0.9	1.6	1.3	-0.5	-1.0	-0.9	-0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.1	-0.5	-1.3	-0.8	-0.6
Neuroticism score	0.6	1.3	2.4	-0.5	0.0	1.5	1.6	1.2
Hip circumference	0.6	2.6	5.4	0.9	2.3	-1.7	1.1	1.7
Father’s age at death	0.6	0.8	1.6	1.2	0.1	-0.4	-1.2	-0.8
Lung cancer (father)	0.6	0.7	1.6	-1.1	-0.7	-0.0	-0.4	1.3
Loud music exposure frequency	0.6	0.7	2.4	0.8	1.5	-0.5	-0.1	-0.6
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.7	-1.3	-0.3	-0.6	-0.9	-1.2
Glaucoma (self-reported)	0.6	0.7	2.7	0.7	0.3	-0.1	0.7	1.6
Leg fat percentage (right)	0.6	2.0	4.0	1.3	1.6	-0.2	1.3	2.0
Exposure to tobacco smoke outside home	0.6	0.8	2.4	1.1	-1.5	-0.5	-0.6	0.3
Chest pain or discomfort	0.6	0.8	2.1	1.1	0.3	-1.5	-0.9	-0.0
Osteoporosis (self-reported)	0.6	0.8	2.4	-0.9	-1.5	0.6	0.5	0.0
Mother’s age at death	0.6	0.8	2.1	0.4	1.5	-1.2	0.2	0.4
Illnesses of father: High blood pressure	0.6	0.7	2.6	-1.6	-0.3	0.5	0.3	-0.8
Leg fat percentage (left)	0.6	2.1	4.1	1.5	1.4	-0.3	1.3	2.0
Commuting to job workplace: Cycle	0.6	0.8	2.3	-0.9	-1.5	0.7	0.5	-0.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	-1.0	0.1	0.7	0.9	1.1
Alzheimer’s Disease (in mother)	0.5	0.6	2.8	-0.2	-0.2	-0.1	0.4	1.7
Crohns Disease (2017)	0.5	1.0	3.9	-2.0	-0.5	0.8	0.5	0.0
Systolic Blood Pressure	0.5	2.7	5.3	-1.3	-2.0	-0.4	-1.5	-2.3
Hand grip strength (left)	0.5	1.4	3.3	0.4	1.0	1.8	1.2	1.1
Average weekly spirits intake	0.5	0.6	2.2	0.6	-1.5	0.3	-0.5	0.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	0.9	-0.7	1.4	-0.1	0.3
Diabetes (mother)	0.5	0.6	2.2	1.5	0.5	-0.2	0.2	-0.8
Financial difficulties in last 2 years	0.5	0.7	2.3	1.5	0.9	0.1	0.1	0.6
Body fat percentage	0.5	1.8	2.9	1.2	1.7	-0.7	1.2	1.7
Eye problems/disorders: None of the above	0.5	0.6	1.9	-0.5	1.4	0.1	0.9	0.5
Medication: Omeprazole	0.5	0.6	2.7	1.6	0.2	0.1	-0.2	-0.6
Supplements: Vitamin C	0.5	0.6	1.3	-0.3	0.8	0.4	0.9	1.2
Illnesses of father: Heart disease	0.5	0.6	2.8	-0.1	-1.7	-0.0	-0.2	0.5
Commuting to job workplace: Walk	0.5	0.5	1.5	0.8	-1.2	-0.6	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.5	-1.9	-0.1	-0.3	-0.2	0.7
Smoking status: Current	0.5	0.8	1.5	1.1	-1.2	1.0	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.6	-0.8	-0.7	0.8	0.8	1.6
Number of self-reported non-cancer illnesses	0.5	1.0	2.1	1.5	0.5	-1.4	-0.6	-0.4
Ever taken oral contraceptive pill	0.5	0.6	0.9	0.8	0.8	0.1	0.7	0.9
Hearing aid user	0.5	0.6	1.7	0.4	-0.5	-1.3	-0.9	0.2
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	1.1	0.2	-1.0	-0.1	0.7
Medication: Atorvastatin	0.5	0.6	1.1	0.1	0.9	-0.5	1.1	0.9
Leg fat mass (left)	0.5	1.9	3.3	1.3	1.7	-0.4	1.2	1.8
Schizophrenia (2018)	0.4	0.7	2.4	-0.2	0.2	0.7	1.5	0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	-1.0	0.6	-0.6	0.1	1.1
HbA1C	0.4	0.4	1.3	0.5	0.1	0.7	1.1	0.5
Hypothyroidism (self reported)	0.4	1.0	2.9	1.7	-1.0	-0.2	-0.9	-0.5
Chronotype (morning person)	0.4	0.8	1.9	-1.2	-0.5	0.5	0.4	1.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.2	-0.1	1.0	-1.1	-0.5	-0.1
Systolic blood pressure, automated reading	0.4	1.2	2.9	-0.9	-0.5	-0.3	-1.3	-1.7
Medication for hormone replacement therapy	0.4	0.4	0.9	-0.6	-0.9	-0.4	-0.5	0.5
Vitamin and mineral supplements	0.4	0.6	1.1	-1.0	-0.2	-0.4	-0.8	-1.0
Supplements: Zinc	0.4	0.4	1.8	-0.1	1.4	-0.2	0.0	0.4
Medication: Co-codamol	0.4	0.4	1.2	1.1	0.9	0.3	0.1	0.4
Current tobacco smoking	0.4	0.6	1.3	0.9	-1.2	0.8	0.2	0.0
Relative age voice broke	0.4	0.7	1.2	-0.2	0.8	0.9	0.8	1.1
Age when periods started (menarche)	0.4	0.9	3.0	-0.4	1.7	0.9	0.7	-0.2
Multivitamins +/- minerals	0.4	0.6	1.1	0.8	0.2	0.3	1.0	1.1
Medication: Ramipril	0.4	0.6	1.4	-0.3	0.6	-1.2	-0.3	-0.9
Fluid intelligence score	0.4	0.8	1.8	0.8	-0.6	0.6	1.1	1.3
Noisy workplace	0.4	0.5	2.3	1.5	0.3	0.4	0.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.6	-1.6	1.4	0.1	0.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.5	1.2	-0.2	-0.7	-0.1	0.3
Exposure to tobacco smoke at home	0.4	0.4	1.2	1.1	-0.8	0.2	0.3	0.0
Breastfed as a baby	0.4	0.4	1.0	-1.0	0.5	-0.1	1.0	-0.2
High blood pressure (siblings)	0.4	0.6	1.4	0.5	-0.0	-1.2	-1.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.8	1.3	-0.2	-0.2	-0.4	-0.6
Leg fat mass (right)	0.4	1.6	2.8	1.1	1.7	-0.5	1.0	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	1.0	-0.6	-0.9	-0.0	-0.5
Average weekly red wine intake	0.4	0.5	1.2	-1.1	-0.9	0.0	-0.3	-0.8
Medication: Gliclazide	0.4	0.5	1.7	0.2	-1.3	0.4	0.1	0.7
Miserableness	0.4	0.8	2.2	-0.1	0.2	1.5	0.5	1.2
Age started oral contraceptive pill	0.4	0.5	2.2	1.5	0.2	0.3	0.5	0.4
Unable to work because of sickness or disability	0.4	0.5	1.1	-1.1	1.0	0.1	-0.3	0.3
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.8	-0.2	-0.3	1.0	1.3	1.0
Reaction Time	0.3	0.5	0.9	-0.9	0.9	0.9	0.5	0.3
Ovarian Cancer	0.3	0.4	0.9	0.5	-0.6	0.0	0.6	1.0
Prostate Cancer	0.3	0.5	1.1	-1.1	0.4	0.8	0.3	-0.6
Bipolar Disorder (2011)	0.3	0.3	1.1	-1.1	0.4	-0.1	0.1	-0.4
Smoking Status	0.3	0.6	1.3	0.8	-1.1	0.4	0.1	-1.1
Trunk fat percentage	0.3	1.4	2.8	1.0	1.7	-0.9	0.9	1.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	-0.2	0.4	0.4	0.7	0.8
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.8	-0.9	-0.1	-0.8	-0.2
Body mass index (BMI)	0.3	1.4	2.6	1.1	1.4	-0.7	1.0	1.6
Trunk fat mass	0.3	1.3	2.7	1.0	1.7	-0.9	0.8	1.2
Weight	0.3	1.3	3.1	1.1	1.7	-0.7	0.8	1.2
Arm fat percentage (right)	0.3	1.2	2.0	0.5	1.3	-0.8	1.1	1.4
Time employed in main current job	0.3	0.4	1.0	0.1	-1.0	0.5	0.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	0.9	0.6	-1.1	-0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	0.2	0.2	-0.7	-0.5	-1.1
Arm fat mass (right)	0.3	1.1	2.0	0.8	1.4	-0.7	0.9	1.1
Birth weight	0.3	0.6	1.8	-0.6	-1.3	-0.1	-0.6	0.6
Comparative body size at age 10	0.3	0.9	2.2	-0.3	-0.6	1.5	1.2	0.7
Health satisfaction	0.3	0.4	1.0	-0.4	-0.6	-0.8	-1.0	-0.0
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.7	-0.6	0.2	0.8	0.1
Whole body fat mass	0.3	1.2	2.1	1.1	1.5	-0.8	0.8	1.2
Family relationship satisfaction	0.3	0.4	1.4	-0.0	-1.2	0.6	0.2	-0.0
Knee pain experienced in last month	0.3	0.5	1.9	1.4	0.8	-0.0	0.2	0.3
Arm fat percentage (left)	0.3	1.1	2.2	0.3	1.3	-0.7	1.0	1.5
Arm fat mass (left)	0.3	1.2	2.3	0.7	1.5	-0.5	1.1	1.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.7	0.9	0.1	0.4	1.0	1.3
Cholesterol lowering medication	0.3	0.5	2.5	1.6	0.0	-0.2	-0.0	-0.2
Heart disease (siblings)	0.3	0.3	1.4	0.0	-0.2	-1.2	0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.8	0.0	-0.5	0.7	0.9
Schizophrenia (2014)	0.2	0.5	1.4	-1.0	0.2	0.0	1.2	-0.1
BMI	0.2	1.1	2.1	0.4	1.5	-1.1	0.7	1.4
Lung FEV1/FVC ratio	0.2	1.2	2.9	-0.3	1.7	0.6	1.4	0.7
Tanning	0.2	2.1	6.7	0.9	0.4	2.6	1.4	0.9
Sensitivity / hurt feelings	0.2	0.4	0.9	-0.6	0.7	-0.9	0.2	-0.3
Diabetes (father)	0.2	0.3	0.6	-0.4	0.4	0.3	0.6	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.5	-0.8	0.5	-0.2	0.0
Medication: Levothyroxine sodium	0.2	0.3	1.1	1.0	-0.4	0.4	-0.1	0.2
Waist circumference	0.2	0.9	2.3	1.5	0.9	-0.8	0.3	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.1	0.6	0.8	0.9	-0.3
Impedance of arm (right)	0.2	0.7	1.6	-0.7	-0.4	-0.7	-1.0	-1.3
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.7	0.4	-0.8	0.0	-0.5
Worrier / anxious feelings	0.2	0.3	1.0	-0.2	-1.0	0.2	-0.5	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.2	-0.6	-0.9	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	0.2	0.4	0.7	0.9	1.1
Impedance of arm (left)	0.2	0.9	2.0	-0.9	-0.4	-0.7	-1.0	-1.4
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.8	0.5	-0.5	-0.7	-1.0
Peak expiratory flow (PEF)	0.2	0.5	1.7	1.3	-0.9	0.0	-0.0	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	0.3	-1.1	0.4	-0.3	0.3
Gout (self-reported)	0.2	0.3	1.0	-0.4	0.1	1.0	-0.4	0.1
Age at first live birth	0.2	0.4	1.1	-0.6	1.1	0.8	0.1	-0.1
Shortness of breath walking on level ground	0.2	0.2	0.8	-0.2	-0.3	-0.9	-0.5	-0.1
Medication: Blood pressure	0.2	0.3	1.0	-0.1	1.0	-0.4	0.3	-0.6
Mean time to correctly identify matches	0.2	0.3	0.9	-0.5	0.7	1.0	0.0	-0.1
Age at last live birth	0.2	0.3	0.6	-0.5	-0.6	0.8	-0.4	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.1	-1.1	-0.3	-0.1	0.1	-0.1
Smoking status: Previous	0.2	0.2	0.6	-0.1	-0.1	-0.7	0.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.7	0.2	1.3	0.5	0.4	0.2
Friendships satisfaction	0.2	0.3	0.6	-0.4	-0.8	0.3	0.5	0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.2	-0.3	1.0	0.1	0.7
Guilty feelings	0.2	0.3	0.9	-0.4	-0.2	1.0	0.5	0.3
Arm fat-free mass (left)	0.2	0.9	2.0	1.4	1.3	-0.1	0.7	0.7
Supplements: Calcium	0.2	0.2	0.4	0.6	0.5	-0.2	0.3	0.6
Arm predicted mass (left)	0.2	1.0	2.1	1.5	1.2	0.2	0.8	0.7
Depression (Nagel 2018)	0.1	0.1	0.3	-0.4	-0.0	0.6	-0.3	-0.1
Breast Cancer	0.1	0.2	0.6	-0.1	-0.6	0.8	-0.1	-0.4
Neuroticism (2016)	0.1	0.2	0.5	-0.1	-0.7	0.3	-0.1	-0.5
Heel T-Score	0.1	0.7	1.3	-0.5	-1.1	1.0	0.7	-0.6
Lung FVC	0.1	0.4	1.7	0.5	-1.3	-0.3	-0.4	-0.1
Hair Pigment	0.1	2.6	5.5	2.4	-2.1	-0.6	-1.3	-0.9
Leg fat-free mass (left)	0.1	0.4	1.0	0.3	1.0	-0.9	-0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.1	0.2	-0.5	-0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.9	-0.2	-0.1	1.0	0.4	-0.1
Medication: Atenolol	0.1	0.1	0.2	-0.4	0.5	0.2	0.1	-0.3
Sitting height	0.1	0.9	4.4	0.1	2.1	-0.3	0.3	-0.2
Leg predicted mass (left)	0.1	0.4	1.3	0.3	1.2	-0.8	-0.0	0.3
Nervous feelings	0.1	0.3	0.6	-0.6	-0.0	0.3	0.8	0.4
Had menopause	0.1	0.1	0.2	0.5	-0.4	0.1	0.3	0.3
Forced vital capacity (FVC)	0.1	0.4	0.6	-0.1	0.7	0.7	0.5	0.8
Falls in the last year	0.1	0.1	0.3	0.4	-0.3	-0.3	0.6	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	0.2	0.5	0.7	0.6	0.8
Pulse rate	0.1	0.1	0.3	0.6	0.2	-0.1	-0.5	-0.3
Headache pain in last month	0.1	0.3	0.8	-0.1	0.3	-0.9	-0.3	-0.5
Arm fat-free mass (right)	0.1	0.5	1.4	1.0	1.2	0.0	0.3	0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	0.5	0.0	0.2	-0.4	0.2
Medication: Allopurinol	0.1	0.2	0.4	0.2	0.5	0.0	-0.6	-0.3
Arm predicted mass (right)	0.1	0.7	1.5	1.2	1.1	0.3	0.5	0.5
Pulse rate, automated reading	0.1	0.4	0.9	0.2	0.6	0.8	0.2	1.0
Whole body fat-free mass	0.1	0.3	0.9	0.6	0.9	-0.5	0.0	0.1
Leg fat-free mass (right)	0.1	0.3	0.8	0.5	0.9	-0.8	0.1	0.2
Mood swings	0.1	0.2	0.5	-0.1	-0.2	0.4	0.7	0.4
Whole body water mass	0.1	0.3	0.9	0.7	1.0	-0.4	0.1	0.2
Leg predicted mass (right)	0.1	0.3	0.8	0.5	0.9	-0.8	0.0	0.1
Medication: Lisinopril	0.1	0.2	0.3	-0.5	0.5	-0.5	-0.2	-0.3
Ever smoked	0.1	0.3	0.5	-0.2	-0.6	-0.5	-0.5	-0.7
Basal metabolic rate	0.1	0.6	1.6	0.8	1.3	-0.6	0.3	0.4
Number of operations (self-reported)	0.1	0.1	0.2	0.1	0.5	-0.1	-0.1	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.4	0.4	-0.1	0.6	0.1	0.2
Irritability	0.1	0.2	0.5	0.3	-0.5	-0.2	0.3	-0.7
Risk taking	0.1	0.2	0.4	0.6	0.7	0.3	0.4	0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.6	-0.5	0.8	-0.3	-0.7	-0.5
Impedance of whole body	0.1	0.3	1.1	-0.5	-0.1	0.1	-0.5	-1.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.2	-0.4	-0.2	0.2	-0.3
Blood Red Count	0.0	0.3	0.8	0.4	0.1	-0.9	-0.7	-0.2
Height	0.0	0.8	2.8	0.4	-0.6	-0.4	-0.7	-1.7
Impedance of leg (right)	0.0	0.2	0.7	-0.3	0.3	0.8	-0.0	-0.3
Impedance of leg (left)	0.0	0.1	0.5	-0.0	0.2	0.7	0.2	-0.3
Past tobacco smoking	0.0	0.1	0.2	-0.1	-0.1	0.4	-0.4	0.2
Pain all over the body in last month	0.0	0.0	0.1	0.1	-0.3	0.3	0.1	-0.1
Trunk fat-free mass	0.0	0.2	0.7	0.7	0.8	-0.2	0.2	0.3
Trunk predicted mass	0.0	0.2	0.7	0.7	0.8	-0.1	0.1	0.2
Standing height	0.0	0.4	0.9	0.3	0.9	-0.1	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.0	0.2	0.5	0.2	0.4	0.2	0.3	0.7
Comparative height size at age 10	0.0	0.1	0.2	-0.1	0.2	0.1	0.2	-0.5

Hub : Genes

TNFSF13B

Models

Trait associations