Hub : Genes

TNIP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0970	0.0380	0.0017	0.032	0.019	0.004	0.025	0.015	6.9e-05	0.00180	8.5e-02	4.3e-04	5.3e-03
2	GTEx	Brain Cerebellar Hemisphere	0.4690	0.1100	0.0020	0.011	NA	0.012	NA	0.014	1.6e-01	NA	1.5e-01	NA	1.4e-01
3	GTEx	Thyroid	0.1260	0.0500	0.0025	0.028	NA	0.048	NA	0.022	3.1e-03	NA	1.4e-04	NA	7.5e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0724	0.0344	0.0084	0.001	0.005	0.011	0.016	0.018	2.3e-01	0.06000	1.1e-02	3.5e-03	1.9e-03
5	YFS	Blood	0.0266	0.0120	0.0022	0.017	0.009	0.024	0.019	0.021	1.7e-06	0.00035	2.2e-08	6.8e-07	1.5e-07
6	TCGA	Breast Invasive Carcinoma	0.0568	0.0249	0.0011	0.001	0.014	0.012	NA	0.004	1.5e-01	0.00050	1.1e-03	NA	4.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.8	1.2	4.2	0.3	1.3	0.3	0.3	-2.0	1.1
Bipolar Disorder or Schizophrenia	0.2	0.5	2.0	-0.3	-0.7	0.1	0.8	-1.4	0.1
Depressed Affect (Nagel 2018)	1.4	2.9	8.1	-0.8	-1.3	-2.1	-0.5	2.9	-1.4
Depression (Nagel 2018)	1.2	1.8	4.4	-0.2	-0.9	-2.1	-0.9	1.8	1.1
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.6	-0.4	1.1	0.8	1.5	1.9	1.0
Neuroticism (Nagel 2018)	0.8	1.8	5.0	-0.4	-0.4	-2.0	-1.1	2.2	-0.0
Schizophrenia (2018)	0.4	0.9	3.5	-0.6	-1.9	-0.1	0.9	-0.2	-0.7
Schizophrenia vs Biploar Disorder	2.0	2.6	6.5	-0.5	-1.9	-1.2	1.0	1.6	-2.6
Worry (Nagel 2018)	0.6	1.2	4.2	-0.2	-0.2	-0.9	-0.4	2.0	1.4
Alzheimer’s Disease (in mother)	2.9	3.4	14.6	1.0	3.8	0.9	-0.1	-1.2	1.7
Alzheimer’s Disease (in father)	0.3	0.4	0.9	-0.4	-0.9	0.6	0.8	0.2	0.1
Alzheimer’s Disease (including proxy)	1.7	2.5	7.3	0.9	2.7	1.2	0.8	-1.9	1.0
Crohns Disease (2017)	1.6	3.4	12.5	-3.5	-0.5	1.0	-1.9	1.4	0.9
Irritable Bowel Disease (IBD)	1.9	4.6	19.2	-4.4	-0.6	0.3	-2.3	1.6	-0.5
Ulcerative Colitis (UC)	1.6	3.1	12.1	-3.5	-0.7	-0.0	-1.9	1.1	-1.1
Major Depression (MDD)	0.3	0.4	1.8	-0.2	-0.3	-0.5	-1.3	-0.3	0.1
Reaction Time	0.6	1.2	6.6	-0.5	0.0	0.0	-0.1	-0.6	2.6
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.0	1.2	0.9	0.1	1.7	1.1	1.3
Breast Cancer	0.3	0.7	1.2	-1.1	1.0	0.4	1.0	-0.9	-0.4
Ovarian Cancer	0.7	0.9	2.2	-0.3	0.1	-0.9	1.5	1.4	-0.4
Prostate Cancer	0.4	0.5	1.7	-1.3	-0.9	-0.4	0.6	0.1	-0.1
Age at First Birth	0.6	0.9	1.6	0.9	0.8	0.4	-0.9	-1.3	1.1
Bipolar Disorder (2011)	0.7	0.7	2.0	0.6	1.4	0.8	0.0	-0.5	0.8
Body Mass Index (BMI) (2010)	0.6	0.8	3.7	-0.2	-0.8	0.2	1.9	0.5	-0.6
Coronary Artery Disease (CAD)	0.8	1.0	2.8	0.8	1.2	1.7	0.0	-0.0	1.0
Crohns Disease (2012)	2.1	3.3	12.0	-3.5	-1.2	2.1	-0.8	1.2	0.2
Mean Putamen Volume	1.2	1.3	4.5	-2.1	0.3	-0.4	-0.1	-1.5	-1.0
Fasting Glucose	0.7	0.9	2.9	0.2	-0.1	-1.7	-1.0	1.0	-0.4
HbA1C	0.4	0.5	1.0	0.5	0.6	1.0	1.0	0.5	-0.2
HDL Cholesterol	0.3	0.4	1.5	-0.1	1.2	-0.3	1.0	-0.0	-0.1
LDL Cholesterol	0.4	0.6	1.2	1.0	-0.5	-1.0	1.1	0.2	-0.1
Lupus	5.7	8.6	20.9	4.2	2.6	4.6	2.1	0.1	1.4
Neuroticism (2016)	0.5	0.8	1.8	0.2	-0.4	-1.3	-0.5	1.4	0.9
Primary Biliary Cirrhosis	3.6	5.2	10.3	2.8	2.5	3.2	1.0	-1.2	2.0
Rheumatoid Arthritis	1.0	1.4	3.5	0.8	1.2	0.8	0.7	1.4	1.9
Schizophrenia (2014)	0.8	1.8	7.2	-0.9	-2.7	-0.2	0.9	-0.5	-1.2
Triglycerides	0.1	0.2	0.6	-0.3	-0.7	-0.4	0.4	0.1	-0.6
Type 2 Diabetes (T2D) (2012)	1.5	1.8	2.9	-1.3	0.6	1.7	-1.7	-1.7	-0.2
Ulcerative Colitis	2.2	3.1	12.3	-3.5	-0.3	0.5	-2.1	-0.0	-1.3
Blood Eosinophil Count	1.3	9.9	28.5	-5.3	-4.0	-2.3	-2.4	-0.0	-2.0
Blood Platelet Count	0.3	3.9	9.3	-1.8	-2.3	-0.2	-2.4	-3.0	0.0
Blood Red Count	0.1	1.3	3.7	-0.3	-1.0	1.9	-0.4	-1.4	1.0
Blood White Count	0.5	3.5	9.6	-3.1	-2.8	-1.1	-1.4	0.1	0.4
Heel T-Score	0.6	5.0	11.0	2.7	1.0	2.0	3.3	-0.3	2.5
BMI	0.1	0.3	0.7	0.8	0.7	-0.1	0.8	-0.3	0.3
Height	0.0	0.9	5.0	0.2	-0.6	-0.3	-0.1	2.2	0.3
Waist Hip Ratio (WHR)	0.3	1.4	3.9	-0.8	-1.7	0.0	-2.0	-0.8	-0.3
Systolic Blood Pressure	0.0	0.2	0.5	0.5	0.6	0.0	-0.7	-0.5	0.0
Smoking Status	0.9	2.1	4.0	-2.0	-1.6	-1.2	-1.7	0.3	-1.4
Allergy or Eczema	0.3	0.9	2.5	-1.6	0.1	-1.1	-0.7	-0.2	1.1
Cardiovascular Disease	0.9	3.0	7.1	1.8	1.9	1.2	1.5	-2.7	0.7
Hypothyroidism (self reported)	0.3	0.7	2.9	1.7	0.6	-0.2	0.2	-0.6	0.7
Respiratory disease	0.4	1.0	3.6	-1.9	-0.3	-1.2	-0.6	0.5	0.0
Type 2 Diabetes (T2D) (2018)	1.9	3.5	8.2	2.9	2.5	1.1	0.2	0.9	2.1
Lung FEV1/FVC ratio	0.9	4.8	17.3	-1.0	-4.2	-1.4	-0.1	2.9	-0.6
Lung FVC	0.1	0.6	1.3	-0.1	-1.1	-0.5	0.7	1.1	-0.5
Neuroticism	0.8	1.8	6.7	0.8	-0.5	-1.7	-0.7	2.6	0.2
Chronotype (morning person)	0.7	1.6	4.2	-1.2	-2.1	-0.5	-0.2	1.0	-1.6
Hair Pigment	0.0	0.6	1.7	0.3	-0.4	1.2	-1.3	-0.7	0.2
Tanning	0.1	0.8	3.1	0.8	0.4	0.8	0.5	-0.2	-1.8
Hand grip strength (left)	0.3	0.9	3.5	1.9	0.3	-1.0	-0.3	-0.0	-0.7
Number of treatments/medications taken	0.3	0.6	2.2	0.8	-0.6	-0.4	0.1	1.5	0.5
Average weekly spirits intake	1.3	1.6	3.4	-1.8	-1.6	-0.2	-0.9	1.4	-0.9
Sensitivity / hurt feelings	0.5	0.9	4.2	-0.2	-0.1	-1.1	-2.0	0.3	0.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	-0.5	-1.1	-1.4	-0.1	1.1	0.8
Hearing difficulty/problems: Yes	0.3	0.5	2.3	0.8	-0.2	-0.3	0.2	1.5	-0.2
Relative age of first facial hair	0.3	0.6	1.8	-0.6	-0.2	1.1	0.4	-1.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	0.3	-0.1	-0.9	-0.3	-0.0	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.2	-0.3	-1.2	-0.7	-0.5	0.6	-1.5
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	0.0	1.1	-1.3	1.1	1.0	0.3
Systolic blood pressure, automated reading	0.2	0.7	1.7	0.8	0.9	1.0	1.3	-0.3	0.2
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.8	0.3	1.3	2.2	0.5	-2.2	1.3
Angina	0.9	1.2	5.6	0.3	0.7	-0.4	-0.1	2.4	0.7
Medication for hormone replacement therapy	0.5	0.5	1.2	-0.4	-0.8	-0.8	-1.1	-0.6	0.1
Vitamin and mineral supplements	1.5	2.0	9.1	-0.5	3.0	-0.1	1.5	0.7	0.2
Supplements: Zinc	1.8	1.9	5.3	0.8	-2.3	0.3	-1.3	-1.7	1.0
Medication: Co-codamol	0.5	0.5	2.0	-1.4	-0.6	-0.4	0.6	-0.6	0.1
Medication: Metformin	0.9	1.2	3.6	1.4	1.9	0.3	-0.2	-0.0	1.2
Diabetes (father)	0.4	0.4	1.6	0.2	-0.3	-0.5	0.6	0.5	1.3
Diabetes (mother)	1.2	1.5	5.8	-0.6	0.8	-1.1	-2.4	-1.1	-0.4
Severe depression (siblings)	0.5	0.6	1.2	1.1	-0.1	-1.0	0.1	1.1	0.5
Pack years adult smoking proportion	1.0	1.5	3.9	0.8	1.0	-0.8	1.7	2.0	-0.4
Impedance of leg (right)	0.1	0.5	2.1	-0.1	-0.4	0.9	-1.5	0.1	0.2
Leg fat-free mass (left)	0.1	0.3	0.5	0.7	0.6	-0.5	0.7	-0.4	0.1
Trunk fat percentage	0.1	0.5	1.1	-1.1	0.6	0.1	0.8	-1.0	-0.5
Hand grip strength (right)	0.1	0.3	0.9	0.7	0.2	-0.9	-0.5	0.1	0.1
Townsend deprivation index at recruitment	0.3	0.4	1.4	-0.3	-0.4	-0.3	0.7	0.3	-1.2
Current tobacco smoking	0.4	0.7	1.4	-0.7	0.4	-1.2	-0.2	1.0	-1.0
Average weekly fortified wine intake	0.2	0.2	0.5	-0.7	-0.7	0.2	-0.5	-0.3	-0.2
Maternal smoking around birth	1.2	1.7	4.8	0.4	1.7	0.8	2.2	0.3	1.4
Fed-up feelings	0.9	1.7	5.9	-0.2	0.6	-1.9	-0.5	2.4	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	0.1	0.4	-1.3	-0.2	0.4	1.0
Relative age voice broke	1.7	2.6	7.8	-0.2	-0.4	2.8	-0.2	-2.7	-0.6
Taking other prescription medications	0.8	1.2	2.8	0.8	-0.9	-1.7	0.2	1.6	-0.2
Age when periods started (menarche)	0.3	0.7	1.1	-1.0	-0.9	0.8	0.6	0.7	-1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	-0.6	-0.7	-0.7	-0.4	-0.2	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	3.2	1.8	0.8	-0.8	1.2	-0.0	-0.7
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.6	0.2	2.6	-1.5	0.8	0.6	0.6
Qualifications: CSEs or equivalent	1.0	1.4	3.2	0.5	1.8	1.5	-0.9	-1.3	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-1.0	0.0	-0.1	-0.2	-1.0	0.3
High blood pressure	1.3	3.7	9.6	1.2	2.3	0.9	3.1	-1.7	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.1	-1.8	-0.0	0.6	0.2	-1.2	0.6
Multivitamins +/- minerals	0.9	1.2	6.9	0.3	-2.6	0.1	0.0	-0.3	-0.3
Stomach or abdominal pain in last month	1.0	1.3	2.9	-0.3	1.4	0.9	1.4	-0.1	1.7
Supplements: Glucosamine	0.7	1.0	3.3	-1.2	-1.8	0.9	0.4	0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.0	0.4	1.7	-0.8	0.5	0.2	2.0
Medication: Atenolol	0.8	1.0	3.1	0.0	-0.1	1.8	-0.5	-1.6	-0.0
Medication: Levothyroxine sodium	1.1	1.9	8.1	1.1	0.9	1.2	2.8	0.2	-0.0
Sitting height	0.3	2.0	4.5	2.1	0.3	1.8	1.4	-1.3	-0.7
Chronic bronchitis/emphysema (father)	0.7	0.8	3.4	0.9	-0.0	-0.6	-1.8	-0.5	-0.4
High blood pressure (mother)	0.4	0.6	1.5	-0.9	-0.7	-0.6	-0.5	1.2	0.1
Body mass index (BMI)	0.1	0.5	1.3	-0.3	0.7	-0.2	1.1	-1.1	0.0
Impedance of leg (left)	0.2	1.1	3.2	-0.5	-1.1	1.1	-1.8	0.5	-0.7
Leg predicted mass (left)	0.1	0.3	0.6	0.7	0.6	-0.4	0.8	-0.5	0.0
Trunk fat mass	0.1	0.4	0.8	-0.9	0.5	-0.1	0.8	-0.8	-0.4
Waist circumference	0.1	0.2	1.2	-1.1	0.1	-0.1	-0.2	-0.5	0.1
Number of incorrect matches in round	0.3	0.6	0.9	0.8	1.0	-0.7	-0.7	-0.0	0.9
Past tobacco smoking	2.5	4.6	10.9	3.3	3.0	0.0	1.5	1.4	1.9
Alcohol usually taken with meals	0.9	1.5	3.3	-1.8	-0.4	-1.8	-1.5	0.3	0.6
Nervous feelings	0.8	1.5	5.6	0.6	1.2	0.8	0.5	0.8	2.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.1	0.5	-0.5	-1.7	-1.8	0.8	1.3
Hearing difficulty/problems with background noise	0.6	0.9	2.9	1.7	0.6	0.5	0.9	1.1	-0.1
Hair/balding pattern: Pattern 2	0.7	0.9	2.8	-0.5	-0.7	-0.7	-1.1	-0.2	-1.7
Had menopause	0.7	0.9	1.8	0.8	0.6	0.3	1.0	1.2	1.4
Had other major operations	1.0	1.3	3.5	-0.7	-1.9	-1.2	0.0	1.2	-0.9
Forced vital capacity (FVC)	0.4	1.4	2.9	-0.2	-1.3	-1.7	-1.3	1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.5	0.7	0.1	0.1	0.6	-0.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.8	-0.5	0.3	0.1	0.9	0.2	-0.2
Qualifications: None of the above	0.5	1.0	1.8	0.9	-1.1	-1.0	0.4	1.1	-1.4
Financial difficulties in last 2 years	1.0	1.3	5.0	0.3	-1.3	-0.9	-0.2	0.4	-2.2
Mouth/teeth dental problems	0.8	1.2	4.0	-0.2	0.4	-2.0	0.6	1.4	-0.7
Heart attack	0.2	0.2	1.0	0.1	0.1	1.0	0.4	0.1	0.4
Allergy	0.7	1.7	6.0	2.5	0.9	1.1	1.1	0.2	-0.9
Pain all over the body in last month	1.5	1.6	4.5	0.4	-0.7	-2.1	-1.5	0.8	1.4
Diabetes (self-reported)	1.2	1.9	4.0	2.0	1.7	1.1	-0.5	0.1	1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.9	-1.0	-0.3	-0.9	-2.0	0.3	-0.4
Medication: Ramipril	0.9	1.1	2.8	-1.4	-0.8	1.7	0.6	-0.5	1.0
Medication: Simvastatin	0.6	0.9	2.1	0.1	0.7	1.4	0.3	-0.9	1.4
Fluid intelligence score	0.9	1.9	7.0	0.8	0.4	-1.1	1.5	2.6	0.4
Illnesses of siblings	0.6	0.8	2.2	-0.2	0.2	0.2	-0.8	-1.5	1.3
Neuroticism score	0.6	1.3	2.4	1.0	0.9	-1.0	-0.8	1.6	1.3
Weight	0.1	0.3	1.0	-0.0	0.5	-0.0	1.0	-0.6	-0.1
Impedance of arm (right)	0.1	0.6	1.1	-1.1	-0.5	0.8	-1.0	-0.6	-0.3
Arm fat percentage (right)	0.2	0.7	2.7	-0.9	0.4	-0.1	0.8	-1.7	-0.4
Trunk fat-free mass	0.0	0.3	0.8	0.9	0.4	-0.2	0.6	0.3	0.2
Hip circumference	0.1	0.6	1.5	-0.2	1.2	0.2	1.2	-0.5	0.6
Time employed in main current job	1.2	1.4	2.7	1.2	1.6	-0.0	1.2	0.9	1.4
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.0	0.7	0.3	-0.9	-0.7	0.3
Father’s age at death	1.0	1.4	2.7	-0.5	-1.7	0.2	-1.6	-1.4	0.9
Worrier / anxious feelings	0.3	0.6	1.9	0.9	1.4	0.5	-0.4	-0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.7	-0.4	0.6	-1.0	-1.3	0.2	0.3
Falls in the last year	0.2	0.3	0.7	-0.0	-0.8	0.7	-0.0	0.1	0.8
Hair/balding pattern: Pattern 3	0.9	1.4	2.3	1.3	0.3	0.9	1.5	1.5	0.9
Number of live births	0.6	0.8	2.7	-0.7	-1.0	0.6	-0.3	0.5	1.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	4.8	-0.2	-2.2	-1.9	-0.8	2.0	-0.5
Pulse rate	0.4	0.8	2.8	0.3	0.1	0.2	-1.2	-0.6	-1.7
Happiness	1.3	1.6	4.3	0.3	-0.2	-1.5	-1.0	1.3	-2.1
Noisy workplace	0.7	0.9	1.9	1.3	-1.3	-0.2	-0.1	1.4	-0.2
Qualifications: A levels/AS levels or equivalent	0.8	1.9	9.2	-0.3	1.0	-0.5	0.7	3.0	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	4.8	1.2	1.0	-2.1	-0.7	2.2	-0.6
Mouth/teeth dental problems: Dentures	0.7	1.1	4.0	0.3	0.2	1.5	2.0	0.5	0.2
Asthma	1.8	3.5	9.6	-2.1	-0.5	-2.5	-3.1	0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	1.0	0.7	0.7	0.7	-0.8	0.1
Medication: Cholesterol lowering	0.2	0.4	0.7	0.7	0.5	0.6	-0.3	-0.5	0.8
Depression (self-reported)	0.5	0.6	1.0	-1.0	-0.6	-0.6	0.4	0.9	-0.8
Medication: Lansoprazole	0.5	0.5	2.0	0.7	0.2	0.7	1.4	-0.2	0.1
Prospective memory result	0.4	0.5	1.4	1.2	0.8	0.7	0.6	-0.2	-0.2
Lung cancer (father)	1.3	1.5	3.0	1.7	1.4	1.4	0.3	0.5	-1.3
Illnesses of mother	1.2	1.5	4.6	-1.0	-0.8	1.0	0.1	-2.1	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.5	0.1	-1.8	-1.9	-0.8	2.1	-0.3
Pulse wave Arterial Stiffness index	0.5	0.5	2.2	0.1	0.7	0.3	-0.2	-1.5	-0.6
Impedance of arm (left)	0.1	0.6	1.9	-1.4	-0.2	0.7	-0.1	-1.0	-0.3
Arm fat mass (right)	0.1	0.5	1.2	-0.6	0.5	-0.3	1.0	-1.1	-0.3
Trunk predicted mass	0.0	0.3	0.8	0.9	0.3	-0.2	0.7	0.4	0.2
Standing height	0.0	0.4	1.7	0.8	-0.2	0.4	0.2	1.3	-0.1
Length of working week for main job	0.2	0.2	0.6	0.0	-0.0	-0.5	0.8	-0.4	-0.6
Exposure to tobacco smoke at home	0.9	1.0	4.6	0.3	-0.8	0.0	2.1	0.5	-0.4
Breastfed as a baby	0.7	0.9	2.9	-0.7	-0.5	1.3	0.1	-1.7	0.0
Tense / ‘highly strung’	0.8	1.4	3.6	-0.1	-1.1	-1.3	-0.6	1.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.3	-0.4	-0.8	-1.1	-1.0	0.9	0.2
Hair/balding pattern: Pattern 4	1.0	2.5	4.9	-1.4	-1.4	-2.2	-0.9	2.2	0.8
Birth weight of first child	0.7	1.2	4.3	-0.4	-0.7	-1.0	-0.3	2.1	-1.2
Peak expiratory flow (PEF)	0.6	1.4	3.6	-0.3	-1.4	-1.3	-0.3	1.9	-1.0
Pulse wave reflection index	0.4	0.5	1.8	-0.3	1.3	0.1	-0.7	0.0	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	-0.6	1.4	-0.7	-0.6	0.9	0.4
Loud music exposure frequency	2.4	2.6	12.1	3.5	0.3	1.2	-0.3	-1.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.8	0.3	0.2	-0.1	0.6	1.7	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.9	0.2	-1.4	0.2	-0.1	0.1	0.1
Blood clot in the leg (DVT)	1.4	1.8	3.8	-1.7	-1.6	-1.9	-0.7	-0.8	-0.2
Medication: Paracetamol	0.2	0.3	1.0	0.3	-0.4	-0.5	0.4	1.0	-0.2
Headache pain in last month	0.5	0.9	2.0	1.1	0.5	0.2	0.7	1.4	1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.6	0.5	-0.6	-0.5	-0.3	-0.6
Glaucoma (self-reported)	0.4	0.5	2.0	-0.3	0.3	0.6	1.4	0.4	-0.3
Gout (self-reported)	0.3	0.4	1.5	-0.5	0.2	0.6	0.6	-1.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	5.6	0.7	0.9	1.0	2.4	-0.6	-0.3
Medication: Amlodipine	0.5	0.6	1.7	0.2	-0.4	0.3	1.2	0.6	1.3
Medication: Ventolin 100micrograms inhaler	3.1	4.0	15.9	-1.8	-0.9	-1.6	-4.0	-0.7	1.1
Birth weight	0.2	0.4	1.4	-0.6	-1.2	-0.6	0.4	0.3	-0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.8	0.5	-0.5	1.7	0.0	0.2	0.0
High blood pressure (siblings)	0.2	0.3	1.2	-0.6	0.1	0.1	-0.1	1.1	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.3	2.9	0.6	-1.0	-1.7	-0.9	1.7	-0.3
Body fat percentage	0.1	0.4	1.1	-1.0	0.4	0.0	0.4	-1.0	-0.5
Leg fat percentage (right)	0.1	0.3	1.5	-0.4	0.5	0.2	0.0	-1.2	-0.1
Arm fat-free mass (right)	0.0	0.1	0.2	0.3	0.3	-0.3	0.5	0.0	0.4
Exposure to tobacco smoke outside home	0.4	0.5	1.9	1.4	0.2	-0.7	0.6	0.2	-0.4
Comparative body size at age 10	0.6	1.6	2.8	0.8	0.9	-1.7	1.6	-0.5	1.6
Number of full brothers	0.7	0.9	2.1	-0.7	-1.4	0.6	-1.2	-0.3	-0.9
Worry too long after embarrassment	0.2	0.3	1.3	0.4	-0.0	-0.6	-1.1	-0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.6	1.5	1.1	-0.9	-0.3	1.9	1.0
Wheeze or whistling in the chest in last year	0.8	1.5	5.7	-1.4	-0.6	-0.7	-2.4	-0.4	0.2
Number of children fathered	1.4	1.6	4.3	0.8	-1.0	1.7	0.0	-2.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.9	-0.5	-1.3	-0.7	-1.2	1.4	-0.2
Age at first live birth	0.7	1.3	4.0	1.2	2.0	0.6	1.1	-0.2	0.8
Pulse wave peak to peak time	0.6	0.7	2.7	0.1	-0.9	-0.3	0.2	1.6	0.6
Health satisfaction	0.4	0.5	1.3	0.2	0.6	-1.1	0.6	0.6	-0.9
Shortness of breath walking on level ground	0.8	1.0	4.8	0.1	0.6	0.4	2.2	0.6	-0.4
Qualifications: College or University degree	0.1	0.3	1.3	-0.2	-0.1	-1.1	0.4	0.4	-0.4
Eye problems/disorders: None of the above	0.3	0.4	0.6	-0.5	-0.6	0.8	-0.4	0.8	-0.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.1	-0.6	-1.2	0.8	-1.4	-0.8	-0.7
Emphysema/chronic bronchitis	1.1	1.3	3.8	-1.1	-2.0	-0.2	-1.5	0.4	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	-0.5	0.0	-0.7	-1.4	-0.4	0.3
Neck or shoulder pain in last month	0.7	1.0	4.0	-0.6	-2.0	-1.1	-0.6	-0.0	-0.2
Medication: Blood pressure	0.5	0.8	1.7	1.3	-0.3	1.1	1.2	0.5	0.7
Angina (self-reported)	0.9	1.2	6.2	0.2	0.7	-0.3	0.0	2.5	0.4
Migraine (self-reported)	0.9	1.1	3.2	1.8	0.4	-0.7	0.6	-1.5	0.4
Medication: Ibuprofen	0.4	0.4	1.0	0.4	0.2	0.3	0.7	-1.0	0.8
Medication: Allopurinol	0.4	0.6	2.2	-0.4	0.7	-0.1	0.3	-1.5	-0.7
Medication: Omeprazole	0.3	0.4	0.7	-0.6	-0.6	0.1	0.8	0.9	-0.3
Medication: Seretide 50 evohaler	1.0	1.2	3.6	-1.0	-1.3	0.5	-0.8	-0.1	1.9
Mean time to correctly identify matches	1.0	1.9	7.8	-0.7	-0.0	0.7	1.2	-1.1	2.8
Heart disease (mother)	1.7	2.1	6.0	0.8	-0.1	-2.5	0.3	2.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.9	-0.6	-0.3	-1.1	-0.3	0.9
Whole body fat mass	0.1	0.3	0.7	-0.8	0.2	-0.2	0.6	-0.7	-0.4
Leg fat mass (right)	0.1	0.3	1.1	-0.3	0.6	-0.2	0.3	-1.0	-0.1
Arm predicted mass (right)	0.0	0.2	0.4	0.6	0.1	-0.2	0.6	0.4	0.3
Pulse rate, automated reading	0.1	0.3	1.1	1.0	0.7	0.2	-0.1	0.3	-0.4
Alcohol intake frequency.	1.4	3.3	7.1	1.5	2.7	1.8	0.9	-2.5	0.3
Comparative height size at age 10	0.1	0.5	1.7	-0.3	-0.8	0.2	-0.8	-0.1	1.3
Number of full sisters	0.4	0.5	2.1	-0.2	-0.2	1.4	0.4	-0.5	0.5
Suffer from ‘nerves’	1.4	2.3	3.2	-1.6	0.4	-1.5	-1.5	1.7	1.8
Overall health rating	0.6	1.3	3.3	-1.8	-0.7	-0.2	-0.8	-1.8	0.0
Chest pain or discomfort	0.5	0.7	3.0	-0.9	-0.2	0.8	0.1	1.7	0.0
Had major operations	1.2	1.4	2.9	-0.5	-1.6	-1.6	-0.2	1.7	-0.0
Age at last live birth	1.5	2.2	3.9	1.2	2.0	1.6	0.1	-1.2	1.9
Family relationship satisfaction	0.4	0.5	0.7	-0.3	-0.7	0.6	-0.9	-0.7	-0.8
Leg pain on walking	0.5	0.6	1.5	-1.2	-1.0	-0.9	-0.4	0.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.3	0.0	-0.2	0.2	-1.1	-0.7	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	-0.7	0.1	1.0	-0.1	-0.4	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	3.2	-0.8	-0.6	1.8	0.5	-0.8	0.6
Medication: Aspirin	0.4	0.5	1.5	0.0	0.8	0.5	0.4	1.2	0.5
Supplements: Vitamin C	0.5	0.6	2.8	0.2	-1.7	0.1	-0.6	0.1	0.5
Knee pain experienced in last month	0.4	0.6	2.0	-0.2	0.2	-1.1	-0.1	1.4	0.4
Hypertension (Self-reported)	1.3	3.7	9.9	1.2	2.3	1.1	3.1	-1.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.6	-0.0	-0.5	-1.3	1.7	2.4	-1.7
Illnesses of father: Heart disease	1.9	2.6	7.6	1.4	1.8	-0.4	2.8	1.6	0.6
Illnesses of siblings: Diabetes	1.0	1.2	5.1	-0.4	-0.2	-1.1	-0.3	2.3	-0.8
Smoking status: Previous	3.7	5.5	12.8	-3.6	-3.2	0.0	-2.1	-1.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.4	-0.1	-0.6	-1.2	-0.9	0.2	0.2
Whole body fat-free mass	0.0	0.2	0.6	0.8	0.4	-0.4	0.7	0.1	0.1
Leg fat-free mass (right)	0.0	0.2	0.4	0.3	0.1	-0.6	0.5	-0.0	-0.5
Arm fat percentage (left)	0.3	1.1	3.4	-1.5	0.3	-0.4	0.7	-1.8	-0.5
Average weekly red wine intake	0.6	0.8	2.6	-1.0	0.1	-1.6	-1.1	-0.0	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	1.1	-0.4	-0.1	-1.2	0.4	0.0
Mood swings	2.0	3.6	7.2	-1.3	-2.1	-1.7	-2.7	1.6	-1.8
Loneliness, isolation	0.5	0.7	2.2	1.5	-0.3	-1.4	-0.0	0.0	0.0
Long-standing illness, disability or infirmity	1.1	1.7	2.5	-1.5	-0.4	-1.6	-1.6	0.8	1.6
Ever had bowel cancer screening	1.3	1.5	7.4	-2.7	-0.4	0.1	0.7	-0.5	0.7
Diabetes diagnosed by doctor	1.8	2.9	5.5	2.3	2.2	1.6	-0.1	-0.5	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.3	-0.3	-0.3	-0.7	0.1	0.8
Friendships satisfaction	0.4	0.5	1.0	0.4	-1.0	-0.0	0.4	-0.9	-0.8
Qualifications: nursing, teaching	0.4	0.7	2.3	0.2	0.3	-0.5	-1.5	0.7	0.9
Commuting to job workplace: Walk	0.6	0.6	1.3	0.6	0.2	-0.5	1.1	0.8	1.0
Eye problems/disorders: Cataract	0.4	0.5	1.2	-0.9	-0.1	-0.6	-0.2	-1.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	14.1	-0.9	0.6	0.4	-3.8	-2.4	-0.1
Medication for cholesterol	0.3	0.5	1.8	-0.7	-0.4	0.5	0.6	1.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.9	-1.0	-1.7	-0.0	-0.4	-0.4	0.9
Back pain experienced in last month	1.3	1.9	7.2	-1.2	-2.7	-0.7	-0.5	0.9	-1.0
Mineral and other dietary supplements	0.5	0.6	1.2	0.3	0.9	-0.5	0.9	0.7	-1.1
Breast cancer (self-reported)	0.4	0.5	2.2	-0.3	-0.5	-0.1	-1.5	-0.7	-0.3
Asthma (self-reported)	1.9	3.7	8.5	-2.3	-0.2	-2.8	-2.9	0.3	0.7
Osteoporosis (self-reported)	1.3	1.7	5.1	-1.0	0.0	-0.9	-1.8	2.3	0.2
Osteoarthritis (self-reported)	1.8	2.3	5.9	2.4	0.6	0.1	2.4	0.6	1.3
Medication: Aspirin	0.4	0.5	2.1	-0.4	0.3	0.4	0.3	1.5	0.5
Medication: Gliclazide	3.3	3.8	9.6	2.3	1.5	1.7	1.4	-0.9	3.1
Illnesses of father: None of the above (group 1)	0.1	0.2	0.6	-0.3	-0.2	0.3	-0.4	-0.8	0.2
Smoking status: Current	0.5	0.9	2.1	-0.6	0.1	-1.3	-0.2	1.0	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.7	0.9	-0.4	-0.7	-1.1	1.6	0.1
Whole body water mass	0.1	0.3	0.7	0.9	0.4	-0.4	0.8	0.1	0.2
Leg predicted mass (right)	0.0	0.2	0.3	0.4	0.2	-0.6	0.4	-0.1	-0.5
Arm fat mass (left)	0.2	0.8	1.7	-1.1	0.5	-0.5	1.0	-1.3	-0.4
Number of self-reported non-cancer illnesses	1.0	1.7	3.6	-0.1	0.6	0.0	1.9	-1.6	1.9
Average weekly champagne plus white wine intake	0.2	0.2	1.0	-1.0	0.1	-0.5	-0.1	0.3	0.1
Miserableness	0.4	0.7	3.4	0.4	-0.2	-0.3	0.4	1.9	0.6
Guilty feelings	0.4	0.6	0.9	1.0	0.8	-0.7	-0.3	0.7	1.0
Wears glasses or contact lenses	0.4	0.5	1.8	-1.4	-0.8	0.0	-0.4	0.4	-0.4
Ever taken oral contraceptive pill	1.7	1.9	9.6	0.6	0.5	-0.4	-0.7	-0.7	3.1
Hearing aid user	1.6	1.8	7.6	0.1	0.4	-1.2	-1.2	2.8	0.7
Mother’s age at death	0.8	1.0	2.4	0.9	0.5	-1.5	-0.9	1.0	1.0
Financial situation satisfaction	1.3	1.6	4.8	-0.9	-1.3	-0.9	-0.7	1.1	-2.2
Tinnitus: Yes, now most or all of the time	2.6	3.1	5.7	-1.7	-1.8	-2.4	-2.0	0.8	-1.4
Commuting to job workplace: Public transport	1.4	1.6	3.2	0.5	0.2	1.2	1.6	-1.8	1.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.4	0.4	0.1	0.6	1.6	-0.0	-0.7
Medication: Blood pressure	0.3	0.5	2.2	0.3	1.5	-0.6	0.1	-0.7	-0.3
Pain type(s) experienced in last month: Hip pain	2.1	2.6	9.1	-1.7	-3.0	-1.6	-0.6	0.8	-0.5
Supplements: Fish oil (including cod liver oil)	1.2	1.5	4.8	-0.6	-1.1	0.4	-1.3	-1.0	2.2
High cholesterol (Self-reported)	0.1	0.2	0.6	0.4	0.2	0.3	0.1	-0.3	0.7
Medication: Bendroflumethiazide	0.2	0.3	1.4	0.1	-0.0	0.1	-0.1	-1.2	0.7
Medication: Paracetamol	0.4	0.6	2.1	0.6	-0.6	-0.2	1.5	0.8	-0.5
Medication: Lisinopril	0.6	0.8	2.0	1.4	0.3	0.7	-0.3	-1.2	0.8
Medication: Atorvastatin	0.4	0.5	1.4	-0.0	-1.2	0.1	-1.1	0.7	-0.2
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.6	0.3	0.2	0.3	-0.6	-0.7
Alcohol drinker status: Never	1.5	1.8	5.7	0.3	2.4	0.7	1.9	-0.5	0.7
Ever smoked	1.0	1.7	5.3	-2.3	-1.2	0.2	-1.1	-1.2	-1.0
Basal metabolic rate	0.0	0.2	0.5	0.5	0.4	-0.3	0.7	-0.1	-0.0
Leg fat percentage (left)	0.1	0.3	0.8	-0.7	0.1	0.3	-0.1	-0.9	-0.6
Arm fat-free mass (left)	0.1	0.4	1.1	1.1	0.6	-0.0	0.7	0.5	0.2
Number of operations (self-reported)	1.2	1.8	4.3	-0.9	-2.1	-1.2	0.1	1.6	1.4
Average weekly beer plus cider intake	0.6	0.9	3.7	0.4	0.4	0.1	0.2	-1.0	1.9
Irritability	1.2	2.0	4.3	-0.3	-0.3	-2.0	-2.1	1.5	-1.2
Risk taking	0.6	0.9	1.4	0.9	-1.1	-1.1	1.2	0.6	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.1	-1.0	-0.4	0.9	0.9	0.3	1.0
Fractured/broken bones in last 5 years	1.0	1.3	2.6	-1.5	-1.0	-0.1	-1.6	-1.2	0.9
Age started oral contraceptive pill	0.3	0.4	1.2	-0.4	-0.2	1.0	1.1	-0.4	0.1
Diastolic blood pressure, automated reading	0.5	1.4	2.3	1.5	1.5	0.7	1.4	-1.1	0.5
Ever depressed for a whole week	0.5	0.6	2.0	0.1	-0.7	-1.4	-0.8	0.4	-0.3
Unable to work because of sickness or disability	1.2	1.6	3.6	-0.5	-0.6	-1.5	-1.3	1.9	1.2
Commuting to job workplace: Cycle	0.1	0.2	0.5	0.4	-0.0	-0.3	0.7	0.3	-0.4
Myopia	0.4	0.6	1.1	1.0	0.5	0.9	-0.3	-0.8	0.9
Vascular/heart problems diagnosed by doctor	1.4	3.8	9.3	-1.3	-2.6	-0.9	-3.1	1.4	-1.5
Cholesterol lowering medication	0.2	0.4	0.8	-0.6	-0.8	-0.1	-0.5	0.3	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.2	-0.2	-0.3	1.1	1.3	-0.3
Pain experienced in last month	0.4	0.7	2.6	-0.3	0.9	0.5	1.6	-0.3	-0.7
Supplements: Calcium	1.5	1.7	3.0	1.4	-1.1	-1.5	-1.7	1.4	0.0
Basal cell carcinoma (self-reported)	2.4	2.8	8.1	0.8	0.2	1.7	2.8	0.2	2.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	-0.1	0.1	0.7	0.6	0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.0	-1.7	-1.4	-1.5	-0.1	-0.7	-0.0
Heart disease (siblings)	2.1	2.6	8.4	-0.1	-0.6	0.2	2.4	1.0	-2.9
Alcohol drinker status: Previous	1.6	1.8	5.9	-0.1	0.8	1.7	-0.1	-2.4	1.3
Pack years of smoking	1.0	1.4	3.4	0.9	1.1	-0.4	1.8	1.7	-0.0
Impedance of whole body	0.1	0.5	1.1	-0.7	-0.6	0.8	-1.1	0.0	-0.2
Leg fat mass (left)	0.1	0.2	1.0	-0.3	0.5	-0.2	0.1	-1.0	-0.4
Arm predicted mass (left)	0.1	0.4	1.3	1.1	0.6	0.1	0.8	0.2	0.2