Hub : Genes

TNIP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0970 0.0380 0.0017 0.032 0.019 0.004 0.025 0.015 6.9e-05 0.00180 8.5e-02 4.3e-04 5.3e-03
2 GTEx Brain Cerebellar Hemisphere 0.4690 0.1100 0.0020 0.011 NA 0.012 NA 0.014 1.6e-01 NA 1.5e-01 NA 1.4e-01
3 GTEx Thyroid 0.1260 0.0500 0.0025 0.028 NA 0.048 NA 0.022 3.1e-03 NA 1.4e-04 NA 7.5e-03
4 ROSMAP Brain Pre-frontal Cortex 0.0724 0.0344 0.0084 0.001 0.005 0.011 0.016 0.018 2.3e-01 0.06000 1.1e-02 3.5e-03 1.9e-03
5 YFS Blood 0.0266 0.0120 0.0022 0.017 0.009 0.024 0.019 0.021 1.7e-06 0.00035 2.2e-08 6.8e-07 1.5e-07
6 TCGA Breast Invasive Carcinoma 0.0568 0.0249 0.0011 0.001 0.014 0.012 NA 0.004 1.5e-01 0.00050 1.1e-03 NA 4.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.8 1.2 4.2 0.3 1.3 0.3 0.3 -2.0 1.1
Bipolar Disorder or Schizophrenia 0.2 0.5 2.0 -0.3 -0.7 0.1 0.8 -1.4 0.1
Depressed Affect (Nagel 2018) 1.4 2.9 8.1 -0.8 -1.3 -2.1 -0.5 2.9 -1.4
Depression (Nagel 2018) 1.2 1.8 4.4 -0.2 -0.9 -2.1 -0.9 1.8 1.1
Intelligence (Savage-Jansen 2018) 0.5 1.5 3.6 -0.4 1.1 0.8 1.5 1.9 1.0
Neuroticism (Nagel 2018) 0.8 1.8 5.0 -0.4 -0.4 -2.0 -1.1 2.2 -0.0
Schizophrenia (2018) 0.4 0.9 3.5 -0.6 -1.9 -0.1 0.9 -0.2 -0.7
Schizophrenia vs Biploar Disorder 2.0 2.6 6.5 -0.5 -1.9 -1.2 1.0 1.6 -2.6
Worry (Nagel 2018) 0.6 1.2 4.2 -0.2 -0.2 -0.9 -0.4 2.0 1.4
Alzheimer’s Disease (in mother) 2.9 3.4 14.6 1.0 3.8 0.9 -0.1 -1.2 1.7
Alzheimer’s Disease (in father) 0.3 0.4 0.9 -0.4 -0.9 0.6 0.8 0.2 0.1
Alzheimer’s Disease (including proxy) 1.7 2.5 7.3 0.9 2.7 1.2 0.8 -1.9 1.0
Crohns Disease (2017) 1.6 3.4 12.5 -3.5 -0.5 1.0 -1.9 1.4 0.9
Irritable Bowel Disease (IBD) 1.9 4.6 19.2 -4.4 -0.6 0.3 -2.3 1.6 -0.5
Ulcerative Colitis (UC) 1.6 3.1 12.1 -3.5 -0.7 -0.0 -1.9 1.1 -1.1
Major Depression (MDD) 0.3 0.4 1.8 -0.2 -0.3 -0.5 -1.3 -0.3 0.1
Reaction Time 0.6 1.2 6.6 -0.5 0.0 0.0 -0.1 -0.6 2.6
Verbal and Numeric Reasoning (VNR) 0.6 1.4 3.0 1.2 0.9 0.1 1.7 1.1 1.3
Breast Cancer 0.3 0.7 1.2 -1.1 1.0 0.4 1.0 -0.9 -0.4
Ovarian Cancer 0.7 0.9 2.2 -0.3 0.1 -0.9 1.5 1.4 -0.4
Prostate Cancer 0.4 0.5 1.7 -1.3 -0.9 -0.4 0.6 0.1 -0.1
Age at First Birth 0.6 0.9 1.6 0.9 0.8 0.4 -0.9 -1.3 1.1
Bipolar Disorder (2011) 0.7 0.7 2.0 0.6 1.4 0.8 0.0 -0.5 0.8
Body Mass Index (BMI) (2010) 0.6 0.8 3.7 -0.2 -0.8 0.2 1.9 0.5 -0.6
Coronary Artery Disease (CAD) 0.8 1.0 2.8 0.8 1.2 1.7 0.0 -0.0 1.0
Crohns Disease (2012) 2.1 3.3 12.0 -3.5 -1.2 2.1 -0.8 1.2 0.2
Mean Putamen Volume 1.2 1.3 4.5 -2.1 0.3 -0.4 -0.1 -1.5 -1.0
Fasting Glucose 0.7 0.9 2.9 0.2 -0.1 -1.7 -1.0 1.0 -0.4
HbA1C 0.4 0.5 1.0 0.5 0.6 1.0 1.0 0.5 -0.2
HDL Cholesterol 0.3 0.4 1.5 -0.1 1.2 -0.3 1.0 -0.0 -0.1
LDL Cholesterol 0.4 0.6 1.2 1.0 -0.5 -1.0 1.1 0.2 -0.1
Lupus 5.7 8.6 20.9 4.2 2.6 4.6 2.1 0.1 1.4
Neuroticism (2016) 0.5 0.8 1.8 0.2 -0.4 -1.3 -0.5 1.4 0.9
Primary Biliary Cirrhosis 3.6 5.2 10.3 2.8 2.5 3.2 1.0 -1.2 2.0
Rheumatoid Arthritis 1.0 1.4 3.5 0.8 1.2 0.8 0.7 1.4 1.9
Schizophrenia (2014) 0.8 1.8 7.2 -0.9 -2.7 -0.2 0.9 -0.5 -1.2
Triglycerides 0.1 0.2 0.6 -0.3 -0.7 -0.4 0.4 0.1 -0.6
Type 2 Diabetes (T2D) (2012) 1.5 1.8 2.9 -1.3 0.6 1.7 -1.7 -1.7 -0.2
Ulcerative Colitis 2.2 3.1 12.3 -3.5 -0.3 0.5 -2.1 -0.0 -1.3
Blood Eosinophil Count 1.3 9.9 28.5 -5.3 -4.0 -2.3 -2.4 -0.0 -2.0
Blood Platelet Count 0.3 3.9 9.3 -1.8 -2.3 -0.2 -2.4 -3.0 0.0
Blood Red Count 0.1 1.3 3.7 -0.3 -1.0 1.9 -0.4 -1.4 1.0
Blood White Count 0.5 3.5 9.6 -3.1 -2.8 -1.1 -1.4 0.1 0.4
Heel T-Score 0.6 5.0 11.0 2.7 1.0 2.0 3.3 -0.3 2.5
BMI 0.1 0.3 0.7 0.8 0.7 -0.1 0.8 -0.3 0.3
Height 0.0 0.9 5.0 0.2 -0.6 -0.3 -0.1 2.2 0.3
Waist Hip Ratio (WHR) 0.3 1.4 3.9 -0.8 -1.7 0.0 -2.0 -0.8 -0.3
Systolic Blood Pressure 0.0 0.2 0.5 0.5 0.6 0.0 -0.7 -0.5 0.0
Smoking Status 0.9 2.1 4.0 -2.0 -1.6 -1.2 -1.7 0.3 -1.4
Allergy or Eczema 0.3 0.9 2.5 -1.6 0.1 -1.1 -0.7 -0.2 1.1
Cardiovascular Disease 0.9 3.0 7.1 1.8 1.9 1.2 1.5 -2.7 0.7
Hypothyroidism (self reported) 0.3 0.7 2.9 1.7 0.6 -0.2 0.2 -0.6 0.7
Respiratory disease 0.4 1.0 3.6 -1.9 -0.3 -1.2 -0.6 0.5 0.0
Type 2 Diabetes (T2D) (2018) 1.9 3.5 8.2 2.9 2.5 1.1 0.2 0.9 2.1
Lung FEV1/FVC ratio 0.9 4.8 17.3 -1.0 -4.2 -1.4 -0.1 2.9 -0.6
Lung FVC 0.1 0.6 1.3 -0.1 -1.1 -0.5 0.7 1.1 -0.5
Neuroticism 0.8 1.8 6.7 0.8 -0.5 -1.7 -0.7 2.6 0.2
Chronotype (morning person) 0.7 1.6 4.2 -1.2 -2.1 -0.5 -0.2 1.0 -1.6
Hair Pigment 0.0 0.6 1.7 0.3 -0.4 1.2 -1.3 -0.7 0.2
Tanning 0.1 0.8 3.1 0.8 0.4 0.8 0.5 -0.2 -1.8
Hand grip strength (left) 0.3 0.9 3.5 1.9 0.3 -1.0 -0.3 -0.0 -0.7
Number of treatments/medications taken 0.3 0.6 2.2 0.8 -0.6 -0.4 0.1 1.5 0.5
Average weekly spirits intake 1.3 1.6 3.4 -1.8 -1.6 -0.2 -0.9 1.4 -0.9
Sensitivity / hurt feelings 0.5 0.9 4.2 -0.2 -0.1 -1.1 -2.0 0.3 0.1
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.0 -0.5 -1.1 -1.4 -0.1 1.1 0.8
Hearing difficulty/problems: Yes 0.3 0.5 2.3 0.8 -0.2 -0.3 0.2 1.5 -0.2
Relative age of first facial hair 0.3 0.6 1.8 -0.6 -0.2 1.1 0.4 -1.4 -0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.2 0.3 -0.1 -0.9 -0.3 -0.0 1.1
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.2 -0.3 -1.2 -0.7 -0.5 0.6 -1.5
Ever had hysterectomy (womb removed) 0.7 0.8 1.6 0.0 1.1 -1.3 1.1 1.0 0.3
Systolic blood pressure, automated reading 0.2 0.7 1.7 0.8 0.9 1.0 1.3 -0.3 0.2
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 4.8 0.3 1.3 2.2 0.5 -2.2 1.3
Angina 0.9 1.2 5.6 0.3 0.7 -0.4 -0.1 2.4 0.7
Medication for hormone replacement therapy 0.5 0.5 1.2 -0.4 -0.8 -0.8 -1.1 -0.6 0.1
Vitamin and mineral supplements 1.5 2.0 9.1 -0.5 3.0 -0.1 1.5 0.7 0.2
Supplements: Zinc 1.8 1.9 5.3 0.8 -2.3 0.3 -1.3 -1.7 1.0
Medication: Co-codamol 0.5 0.5 2.0 -1.4 -0.6 -0.4 0.6 -0.6 0.1
Medication: Metformin 0.9 1.2 3.6 1.4 1.9 0.3 -0.2 -0.0 1.2
Diabetes (father) 0.4 0.4 1.6 0.2 -0.3 -0.5 0.6 0.5 1.3
Diabetes (mother) 1.2 1.5 5.8 -0.6 0.8 -1.1 -2.4 -1.1 -0.4
Severe depression (siblings) 0.5 0.6 1.2 1.1 -0.1 -1.0 0.1 1.1 0.5
Pack years adult smoking proportion 1.0 1.5 3.9 0.8 1.0 -0.8 1.7 2.0 -0.4
Impedance of leg (right) 0.1 0.5 2.1 -0.1 -0.4 0.9 -1.5 0.1 0.2
Leg fat-free mass (left) 0.1 0.3 0.5 0.7 0.6 -0.5 0.7 -0.4 0.1
Trunk fat percentage 0.1 0.5 1.1 -1.1 0.6 0.1 0.8 -1.0 -0.5
Hand grip strength (right) 0.1 0.3 0.9 0.7 0.2 -0.9 -0.5 0.1 0.1
Townsend deprivation index at recruitment 0.3 0.4 1.4 -0.3 -0.4 -0.3 0.7 0.3 -1.2
Current tobacco smoking 0.4 0.7 1.4 -0.7 0.4 -1.2 -0.2 1.0 -1.0
Average weekly fortified wine intake 0.2 0.2 0.5 -0.7 -0.7 0.2 -0.5 -0.3 -0.2
Maternal smoking around birth 1.2 1.7 4.8 0.4 1.7 0.8 2.2 0.3 1.4
Fed-up feelings 0.9 1.7 5.9 -0.2 0.6 -1.9 -0.5 2.4 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.6 0.1 0.4 -1.3 -0.2 0.4 1.0
Relative age voice broke 1.7 2.6 7.8 -0.2 -0.4 2.8 -0.2 -2.7 -0.6
Taking other prescription medications 0.8 1.2 2.8 0.8 -0.9 -1.7 0.2 1.6 -0.2
Age when periods started (menarche) 0.3 0.7 1.1 -1.0 -0.9 0.8 0.6 0.7 -1.1
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.1 -0.6 -0.7 -0.7 -0.4 -0.2 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 3.2 1.8 0.8 -0.8 1.2 -0.0 -0.7
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 6.6 0.2 2.6 -1.5 0.8 0.6 0.6
Qualifications: CSEs or equivalent 1.0 1.4 3.2 0.5 1.8 1.5 -0.9 -1.3 -0.2
Serious illness, injury or assault to yourself 0.3 0.4 1.0 -1.0 0.0 -0.1 -0.2 -1.0 0.3
High blood pressure 1.3 3.7 9.6 1.2 2.3 0.9 3.1 -1.7 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.1 -1.8 -0.0 0.6 0.2 -1.2 0.6
Multivitamins +/- minerals 0.9 1.2 6.9 0.3 -2.6 0.1 0.0 -0.3 -0.3
Stomach or abdominal pain in last month 1.0 1.3 2.9 -0.3 1.4 0.9 1.4 -0.1 1.7
Supplements: Glucosamine 0.7 1.0 3.3 -1.2 -1.8 0.9 0.4 0.3 -0.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 4.0 0.4 1.7 -0.8 0.5 0.2 2.0
Medication: Atenolol 0.8 1.0 3.1 0.0 -0.1 1.8 -0.5 -1.6 -0.0
Medication: Levothyroxine sodium 1.1 1.9 8.1 1.1 0.9 1.2 2.8 0.2 -0.0
Sitting height 0.3 2.0 4.5 2.1 0.3 1.8 1.4 -1.3 -0.7
Chronic bronchitis/emphysema (father) 0.7 0.8 3.4 0.9 -0.0 -0.6 -1.8 -0.5 -0.4
High blood pressure (mother) 0.4 0.6 1.5 -0.9 -0.7 -0.6 -0.5 1.2 0.1
Body mass index (BMI) 0.1 0.5 1.3 -0.3 0.7 -0.2 1.1 -1.1 0.0
Impedance of leg (left) 0.2 1.1 3.2 -0.5 -1.1 1.1 -1.8 0.5 -0.7
Leg predicted mass (left) 0.1 0.3 0.6 0.7 0.6 -0.4 0.8 -0.5 0.0
Trunk fat mass 0.1 0.4 0.8 -0.9 0.5 -0.1 0.8 -0.8 -0.4
Waist circumference 0.1 0.2 1.2 -1.1 0.1 -0.1 -0.2 -0.5 0.1
Number of incorrect matches in round 0.3 0.6 0.9 0.8 1.0 -0.7 -0.7 -0.0 0.9
Past tobacco smoking 2.5 4.6 10.9 3.3 3.0 0.0 1.5 1.4 1.9
Alcohol usually taken with meals 0.9 1.5 3.3 -1.8 -0.4 -1.8 -1.5 0.3 0.6
Nervous feelings 0.8 1.5 5.6 0.6 1.2 0.8 0.5 0.8 2.4
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.1 0.5 -0.5 -1.7 -1.8 0.8 1.3
Hearing difficulty/problems with background noise 0.6 0.9 2.9 1.7 0.6 0.5 0.9 1.1 -0.1
Hair/balding pattern: Pattern 2 0.7 0.9 2.8 -0.5 -0.7 -0.7 -1.1 -0.2 -1.7
Had menopause 0.7 0.9 1.8 0.8 0.6 0.3 1.0 1.2 1.4
Had other major operations 1.0 1.3 3.5 -0.7 -1.9 -1.2 0.0 1.2 -0.9
Forced vital capacity (FVC) 0.4 1.4 2.9 -0.2 -1.3 -1.7 -1.3 1.4 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.1 0.5 0.7 0.1 0.1 0.6 -0.1 -0.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.8 -0.5 0.3 0.1 0.9 0.2 -0.2
Qualifications: None of the above 0.5 1.0 1.8 0.9 -1.1 -1.0 0.4 1.1 -1.4
Financial difficulties in last 2 years 1.0 1.3 5.0 0.3 -1.3 -0.9 -0.2 0.4 -2.2
Mouth/teeth dental problems 0.8 1.2 4.0 -0.2 0.4 -2.0 0.6 1.4 -0.7
Heart attack 0.2 0.2 1.0 0.1 0.1 1.0 0.4 0.1 0.4
Allergy 0.7 1.7 6.0 2.5 0.9 1.1 1.1 0.2 -0.9
Pain all over the body in last month 1.5 1.6 4.5 0.4 -0.7 -2.1 -1.5 0.8 1.4
Diabetes (self-reported) 1.2 1.9 4.0 2.0 1.7 1.1 -0.5 0.1 1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 3.9 -1.0 -0.3 -0.9 -2.0 0.3 -0.4
Medication: Ramipril 0.9 1.1 2.8 -1.4 -0.8 1.7 0.6 -0.5 1.0
Medication: Simvastatin 0.6 0.9 2.1 0.1 0.7 1.4 0.3 -0.9 1.4
Fluid intelligence score 0.9 1.9 7.0 0.8 0.4 -1.1 1.5 2.6 0.4
Illnesses of siblings 0.6 0.8 2.2 -0.2 0.2 0.2 -0.8 -1.5 1.3
Neuroticism score 0.6 1.3 2.4 1.0 0.9 -1.0 -0.8 1.6 1.3
Weight 0.1 0.3 1.0 -0.0 0.5 -0.0 1.0 -0.6 -0.1
Impedance of arm (right) 0.1 0.6 1.1 -1.1 -0.5 0.8 -1.0 -0.6 -0.3
Arm fat percentage (right) 0.2 0.7 2.7 -0.9 0.4 -0.1 0.8 -1.7 -0.4
Trunk fat-free mass 0.0 0.3 0.8 0.9 0.4 -0.2 0.6 0.3 0.2
Hip circumference 0.1 0.6 1.5 -0.2 1.2 0.2 1.2 -0.5 0.6
Time employed in main current job 1.2 1.4 2.7 1.2 1.6 -0.0 1.2 0.9 1.4
Alcohol intake versus 10 years previously 0.2 0.3 0.8 0.0 0.7 0.3 -0.9 -0.7 0.3
Father’s age at death 1.0 1.4 2.7 -0.5 -1.7 0.2 -1.6 -1.4 0.9
Worrier / anxious feelings 0.3 0.6 1.9 0.9 1.4 0.5 -0.4 -0.2 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 1.7 -0.4 0.6 -1.0 -1.3 0.2 0.3
Falls in the last year 0.2 0.3 0.7 -0.0 -0.8 0.7 -0.0 0.1 0.8
Hair/balding pattern: Pattern 3 0.9 1.4 2.3 1.3 0.3 0.9 1.5 1.5 0.9
Number of live births 0.6 0.8 2.7 -0.7 -1.0 0.6 -0.3 0.5 1.6
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 4.8 -0.2 -2.2 -1.9 -0.8 2.0 -0.5
Pulse rate 0.4 0.8 2.8 0.3 0.1 0.2 -1.2 -0.6 -1.7
Happiness 1.3 1.6 4.3 0.3 -0.2 -1.5 -1.0 1.3 -2.1
Noisy workplace 0.7 0.9 1.9 1.3 -1.3 -0.2 -0.1 1.4 -0.2
Qualifications: A levels/AS levels or equivalent 0.8 1.9 9.2 -0.3 1.0 -0.5 0.7 3.0 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 4.8 1.2 1.0 -2.1 -0.7 2.2 -0.6
Mouth/teeth dental problems: Dentures 0.7 1.1 4.0 0.3 0.2 1.5 2.0 0.5 0.2
Asthma 1.8 3.5 9.6 -2.1 -0.5 -2.5 -3.1 0.0 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.0 1.0 0.7 0.7 0.7 -0.8 0.1
Medication: Cholesterol lowering 0.2 0.4 0.7 0.7 0.5 0.6 -0.3 -0.5 0.8
Depression (self-reported) 0.5 0.6 1.0 -1.0 -0.6 -0.6 0.4 0.9 -0.8
Medication: Lansoprazole 0.5 0.5 2.0 0.7 0.2 0.7 1.4 -0.2 0.1
Prospective memory result 0.4 0.5 1.4 1.2 0.8 0.7 0.6 -0.2 -0.2
Lung cancer (father) 1.3 1.5 3.0 1.7 1.4 1.4 0.3 0.5 -1.3
Illnesses of mother 1.2 1.5 4.6 -1.0 -0.8 1.0 0.1 -2.1 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 4.5 0.1 -1.8 -1.9 -0.8 2.1 -0.3
Pulse wave Arterial Stiffness index 0.5 0.5 2.2 0.1 0.7 0.3 -0.2 -1.5 -0.6
Impedance of arm (left) 0.1 0.6 1.9 -1.4 -0.2 0.7 -0.1 -1.0 -0.3
Arm fat mass (right) 0.1 0.5 1.2 -0.6 0.5 -0.3 1.0 -1.1 -0.3
Trunk predicted mass 0.0 0.3 0.8 0.9 0.3 -0.2 0.7 0.4 0.2
Standing height 0.0 0.4 1.7 0.8 -0.2 0.4 0.2 1.3 -0.1
Length of working week for main job 0.2 0.2 0.6 0.0 -0.0 -0.5 0.8 -0.4 -0.6
Exposure to tobacco smoke at home 0.9 1.0 4.6 0.3 -0.8 0.0 2.1 0.5 -0.4
Breastfed as a baby 0.7 0.9 2.9 -0.7 -0.5 1.3 0.1 -1.7 0.0
Tense / ‘highly strung’ 0.8 1.4 3.6 -0.1 -1.1 -1.3 -0.6 1.9 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.3 -0.4 -0.8 -1.1 -1.0 0.9 0.2
Hair/balding pattern: Pattern 4 1.0 2.5 4.9 -1.4 -1.4 -2.2 -0.9 2.2 0.8
Birth weight of first child 0.7 1.2 4.3 -0.4 -0.7 -1.0 -0.3 2.1 -1.2
Peak expiratory flow (PEF) 0.6 1.4 3.6 -0.3 -1.4 -1.3 -0.3 1.9 -1.0
Pulse wave reflection index 0.4 0.5 1.8 -0.3 1.3 0.1 -0.7 0.0 0.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.0 -0.6 1.4 -0.7 -0.6 0.9 0.4
Loud music exposure frequency 2.4 2.6 12.1 3.5 0.3 1.2 -0.3 -1.4 -0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.8 0.3 0.2 -0.1 0.6 1.7 -0.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.9 0.2 -1.4 0.2 -0.1 0.1 0.1
Blood clot in the leg (DVT) 1.4 1.8 3.8 -1.7 -1.6 -1.9 -0.7 -0.8 -0.2
Medication: Paracetamol 0.2 0.3 1.0 0.3 -0.4 -0.5 0.4 1.0 -0.2
Headache pain in last month 0.5 0.9 2.0 1.1 0.5 0.2 0.7 1.4 1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.4 -0.6 0.5 -0.6 -0.5 -0.3 -0.6
Glaucoma (self-reported) 0.4 0.5 2.0 -0.3 0.3 0.6 1.4 0.4 -0.3
Gout (self-reported) 0.3 0.4 1.5 -0.5 0.2 0.6 0.6 -1.2 -0.3
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 5.6 0.7 0.9 1.0 2.4 -0.6 -0.3
Medication: Amlodipine 0.5 0.6 1.7 0.2 -0.4 0.3 1.2 0.6 1.3
Medication: Ventolin 100micrograms inhaler 3.1 4.0 15.9 -1.8 -0.9 -1.6 -4.0 -0.7 1.1
Birth weight 0.2 0.4 1.4 -0.6 -1.2 -0.6 0.4 0.3 -0.3
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.8 0.5 -0.5 1.7 0.0 0.2 0.0
High blood pressure (siblings) 0.2 0.3 1.2 -0.6 0.1 0.1 -0.1 1.1 -0.7
Forced vital capacity (FVC), Best measure 0.4 1.3 2.9 0.6 -1.0 -1.7 -0.9 1.7 -0.3
Body fat percentage 0.1 0.4 1.1 -1.0 0.4 0.0 0.4 -1.0 -0.5
Leg fat percentage (right) 0.1 0.3 1.5 -0.4 0.5 0.2 0.0 -1.2 -0.1
Arm fat-free mass (right) 0.0 0.1 0.2 0.3 0.3 -0.3 0.5 0.0 0.4
Exposure to tobacco smoke outside home 0.4 0.5 1.9 1.4 0.2 -0.7 0.6 0.2 -0.4
Comparative body size at age 10 0.6 1.6 2.8 0.8 0.9 -1.7 1.6 -0.5 1.6
Number of full brothers 0.7 0.9 2.1 -0.7 -1.4 0.6 -1.2 -0.3 -0.9
Worry too long after embarrassment 0.2 0.3 1.3 0.4 -0.0 -0.6 -1.1 -0.4 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 3.6 1.5 1.1 -0.9 -0.3 1.9 1.0
Wheeze or whistling in the chest in last year 0.8 1.5 5.7 -1.4 -0.6 -0.7 -2.4 -0.4 0.2
Number of children fathered 1.4 1.6 4.3 0.8 -1.0 1.7 0.0 -2.1 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 1.9 -0.5 -1.3 -0.7 -1.2 1.4 -0.2
Age at first live birth 0.7 1.3 4.0 1.2 2.0 0.6 1.1 -0.2 0.8
Pulse wave peak to peak time 0.6 0.7 2.7 0.1 -0.9 -0.3 0.2 1.6 0.6
Health satisfaction 0.4 0.5 1.3 0.2 0.6 -1.1 0.6 0.6 -0.9
Shortness of breath walking on level ground 0.8 1.0 4.8 0.1 0.6 0.4 2.2 0.6 -0.4
Qualifications: College or University degree 0.1 0.3 1.3 -0.2 -0.1 -1.1 0.4 0.4 -0.4
Eye problems/disorders: None of the above 0.3 0.4 0.6 -0.5 -0.6 0.8 -0.4 0.8 -0.6
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.1 -0.6 -1.2 0.8 -1.4 -0.8 -0.7
Emphysema/chronic bronchitis 1.1 1.3 3.8 -1.1 -2.0 -0.2 -1.5 0.4 0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 1.9 -0.5 0.0 -0.7 -1.4 -0.4 0.3
Neck or shoulder pain in last month 0.7 1.0 4.0 -0.6 -2.0 -1.1 -0.6 -0.0 -0.2
Medication: Blood pressure 0.5 0.8 1.7 1.3 -0.3 1.1 1.2 0.5 0.7
Angina (self-reported) 0.9 1.2 6.2 0.2 0.7 -0.3 0.0 2.5 0.4
Migraine (self-reported) 0.9 1.1 3.2 1.8 0.4 -0.7 0.6 -1.5 0.4
Medication: Ibuprofen 0.4 0.4 1.0 0.4 0.2 0.3 0.7 -1.0 0.8
Medication: Allopurinol 0.4 0.6 2.2 -0.4 0.7 -0.1 0.3 -1.5 -0.7
Medication: Omeprazole 0.3 0.4 0.7 -0.6 -0.6 0.1 0.8 0.9 -0.3
Medication: Seretide 50 evohaler 1.0 1.2 3.6 -1.0 -1.3 0.5 -0.8 -0.1 1.9
Mean time to correctly identify matches 1.0 1.9 7.8 -0.7 -0.0 0.7 1.2 -1.1 2.8
Heart disease (mother) 1.7 2.1 6.0 0.8 -0.1 -2.5 0.3 2.1 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 -0.9 -0.6 -0.3 -1.1 -0.3 0.9
Whole body fat mass 0.1 0.3 0.7 -0.8 0.2 -0.2 0.6 -0.7 -0.4
Leg fat mass (right) 0.1 0.3 1.1 -0.3 0.6 -0.2 0.3 -1.0 -0.1
Arm predicted mass (right) 0.0 0.2 0.4 0.6 0.1 -0.2 0.6 0.4 0.3
Pulse rate, automated reading 0.1 0.3 1.1 1.0 0.7 0.2 -0.1 0.3 -0.4
Alcohol intake frequency. 1.4 3.3 7.1 1.5 2.7 1.8 0.9 -2.5 0.3
Comparative height size at age 10 0.1 0.5 1.7 -0.3 -0.8 0.2 -0.8 -0.1 1.3
Number of full sisters 0.4 0.5 2.1 -0.2 -0.2 1.4 0.4 -0.5 0.5
Suffer from ‘nerves’ 1.4 2.3 3.2 -1.6 0.4 -1.5 -1.5 1.7 1.8
Overall health rating 0.6 1.3 3.3 -1.8 -0.7 -0.2 -0.8 -1.8 0.0
Chest pain or discomfort 0.5 0.7 3.0 -0.9 -0.2 0.8 0.1 1.7 0.0
Had major operations 1.2 1.4 2.9 -0.5 -1.6 -1.6 -0.2 1.7 -0.0
Age at last live birth 1.5 2.2 3.9 1.2 2.0 1.6 0.1 -1.2 1.9
Family relationship satisfaction 0.4 0.5 0.7 -0.3 -0.7 0.6 -0.9 -0.7 -0.8
Leg pain on walking 0.5 0.6 1.5 -1.2 -1.0 -0.9 -0.4 0.4 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.3 0.0 -0.2 0.2 -1.1 -0.7 0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.2 -0.7 0.1 1.0 -0.1 -0.4 -1.1
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 3.2 -0.8 -0.6 1.8 0.5 -0.8 0.6
Medication: Aspirin 0.4 0.5 1.5 0.0 0.8 0.5 0.4 1.2 0.5
Supplements: Vitamin C 0.5 0.6 2.8 0.2 -1.7 0.1 -0.6 0.1 0.5
Knee pain experienced in last month 0.4 0.6 2.0 -0.2 0.2 -1.1 -0.1 1.4 0.4
Hypertension (Self-reported) 1.3 3.7 9.9 1.2 2.3 1.1 3.1 -1.7 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 5.6 -0.0 -0.5 -1.3 1.7 2.4 -1.7
Illnesses of father: Heart disease 1.9 2.6 7.6 1.4 1.8 -0.4 2.8 1.6 0.6
Illnesses of siblings: Diabetes 1.0 1.2 5.1 -0.4 -0.2 -1.1 -0.3 2.3 -0.8
Smoking status: Previous 3.7 5.5 12.8 -3.6 -3.2 0.0 -2.1 -1.6 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.4 -0.1 -0.6 -1.2 -0.9 0.2 0.2
Whole body fat-free mass 0.0 0.2 0.6 0.8 0.4 -0.4 0.7 0.1 0.1
Leg fat-free mass (right) 0.0 0.2 0.4 0.3 0.1 -0.6 0.5 -0.0 -0.5
Arm fat percentage (left) 0.3 1.1 3.4 -1.5 0.3 -0.4 0.7 -1.8 -0.5
Average weekly red wine intake 0.6 0.8 2.6 -1.0 0.1 -1.6 -1.1 -0.0 0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.5 1.1 -0.4 -0.1 -1.2 0.4 0.0
Mood swings 2.0 3.6 7.2 -1.3 -2.1 -1.7 -2.7 1.6 -1.8
Loneliness, isolation 0.5 0.7 2.2 1.5 -0.3 -1.4 -0.0 0.0 0.0
Long-standing illness, disability or infirmity 1.1 1.7 2.5 -1.5 -0.4 -1.6 -1.6 0.8 1.6
Ever had bowel cancer screening 1.3 1.5 7.4 -2.7 -0.4 0.1 0.7 -0.5 0.7
Diabetes diagnosed by doctor 1.8 2.9 5.5 2.3 2.2 1.6 -0.1 -0.5 2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.7 0.3 -0.3 -0.3 -0.7 0.1 0.8
Friendships satisfaction 0.4 0.5 1.0 0.4 -1.0 -0.0 0.4 -0.9 -0.8
Qualifications: nursing, teaching 0.4 0.7 2.3 0.2 0.3 -0.5 -1.5 0.7 0.9
Commuting to job workplace: Walk 0.6 0.6 1.3 0.6 0.2 -0.5 1.1 0.8 1.0
Eye problems/disorders: Cataract 0.4 0.5 1.2 -0.9 -0.1 -0.6 -0.2 -1.1 -0.7
Mouth/teeth dental problems: Mouth ulcers 2.2 3.5 14.1 -0.9 0.6 0.4 -3.8 -2.4 -0.1
Medication for cholesterol 0.3 0.5 1.8 -0.7 -0.4 0.5 0.6 1.3 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.9 -1.0 -1.7 -0.0 -0.4 -0.4 0.9
Back pain experienced in last month 1.3 1.9 7.2 -1.2 -2.7 -0.7 -0.5 0.9 -1.0
Mineral and other dietary supplements 0.5 0.6 1.2 0.3 0.9 -0.5 0.9 0.7 -1.1
Breast cancer (self-reported) 0.4 0.5 2.2 -0.3 -0.5 -0.1 -1.5 -0.7 -0.3
Asthma (self-reported) 1.9 3.7 8.5 -2.3 -0.2 -2.8 -2.9 0.3 0.7
Osteoporosis (self-reported) 1.3 1.7 5.1 -1.0 0.0 -0.9 -1.8 2.3 0.2
Osteoarthritis (self-reported) 1.8 2.3 5.9 2.4 0.6 0.1 2.4 0.6 1.3
Medication: Aspirin 0.4 0.5 2.1 -0.4 0.3 0.4 0.3 1.5 0.5
Medication: Gliclazide 3.3 3.8 9.6 2.3 1.5 1.7 1.4 -0.9 3.1
Illnesses of father: None of the above (group 1) 0.1 0.2 0.6 -0.3 -0.2 0.3 -0.4 -0.8 0.2
Smoking status: Current 0.5 0.9 2.1 -0.6 0.1 -1.3 -0.2 1.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.7 0.9 -0.4 -0.7 -1.1 1.6 0.1
Whole body water mass 0.1 0.3 0.7 0.9 0.4 -0.4 0.8 0.1 0.2
Leg predicted mass (right) 0.0 0.2 0.3 0.4 0.2 -0.6 0.4 -0.1 -0.5
Arm fat mass (left) 0.2 0.8 1.7 -1.1 0.5 -0.5 1.0 -1.3 -0.4
Number of self-reported non-cancer illnesses 1.0 1.7 3.6 -0.1 0.6 0.0 1.9 -1.6 1.9
Average weekly champagne plus white wine intake 0.2 0.2 1.0 -1.0 0.1 -0.5 -0.1 0.3 0.1
Miserableness 0.4 0.7 3.4 0.4 -0.2 -0.3 0.4 1.9 0.6
Guilty feelings 0.4 0.6 0.9 1.0 0.8 -0.7 -0.3 0.7 1.0
Wears glasses or contact lenses 0.4 0.5 1.8 -1.4 -0.8 0.0 -0.4 0.4 -0.4
Ever taken oral contraceptive pill 1.7 1.9 9.6 0.6 0.5 -0.4 -0.7 -0.7 3.1
Hearing aid user 1.6 1.8 7.6 0.1 0.4 -1.2 -1.2 2.8 0.7
Mother’s age at death 0.8 1.0 2.4 0.9 0.5 -1.5 -0.9 1.0 1.0
Financial situation satisfaction 1.3 1.6 4.8 -0.9 -1.3 -0.9 -0.7 1.1 -2.2
Tinnitus: Yes, now most or all of the time 2.6 3.1 5.7 -1.7 -1.8 -2.4 -2.0 0.8 -1.4
Commuting to job workplace: Public transport 1.4 1.6 3.2 0.5 0.2 1.2 1.6 -1.8 1.5
Eye problems/disorders: Glaucoma 0.5 0.6 2.4 0.4 0.1 0.6 1.6 -0.0 -0.7
Medication: Blood pressure 0.3 0.5 2.2 0.3 1.5 -0.6 0.1 -0.7 -0.3
Pain type(s) experienced in last month: Hip pain 2.1 2.6 9.1 -1.7 -3.0 -1.6 -0.6 0.8 -0.5
Supplements: Fish oil (including cod liver oil) 1.2 1.5 4.8 -0.6 -1.1 0.4 -1.3 -1.0 2.2
High cholesterol (Self-reported) 0.1 0.2 0.6 0.4 0.2 0.3 0.1 -0.3 0.7
Medication: Bendroflumethiazide 0.2 0.3 1.4 0.1 -0.0 0.1 -0.1 -1.2 0.7
Medication: Paracetamol 0.4 0.6 2.1 0.6 -0.6 -0.2 1.5 0.8 -0.5
Medication: Lisinopril 0.6 0.8 2.0 1.4 0.3 0.7 -0.3 -1.2 0.8
Medication: Atorvastatin 0.4 0.5 1.4 -0.0 -1.2 0.1 -1.1 0.7 -0.2
Illnesses of father: High blood pressure 0.2 0.2 0.5 -0.6 0.3 0.2 0.3 -0.6 -0.7
Alcohol drinker status: Never 1.5 1.8 5.7 0.3 2.4 0.7 1.9 -0.5 0.7
Ever smoked 1.0 1.7 5.3 -2.3 -1.2 0.2 -1.1 -1.2 -1.0
Basal metabolic rate 0.0 0.2 0.5 0.5 0.4 -0.3 0.7 -0.1 -0.0
Leg fat percentage (left) 0.1 0.3 0.8 -0.7 0.1 0.3 -0.1 -0.9 -0.6
Arm fat-free mass (left) 0.1 0.4 1.1 1.1 0.6 -0.0 0.7 0.5 0.2
Number of operations (self-reported) 1.2 1.8 4.3 -0.9 -2.1 -1.2 0.1 1.6 1.4
Average weekly beer plus cider intake 0.6 0.9 3.7 0.4 0.4 0.1 0.2 -1.0 1.9
Irritability 1.2 2.0 4.3 -0.3 -0.3 -2.0 -2.1 1.5 -1.2
Risk taking 0.6 0.9 1.4 0.9 -1.1 -1.1 1.2 0.6 -0.7
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.1 -1.0 -0.4 0.9 0.9 0.3 1.0
Fractured/broken bones in last 5 years 1.0 1.3 2.6 -1.5 -1.0 -0.1 -1.6 -1.2 0.9
Age started oral contraceptive pill 0.3 0.4 1.2 -0.4 -0.2 1.0 1.1 -0.4 0.1
Diastolic blood pressure, automated reading 0.5 1.4 2.3 1.5 1.5 0.7 1.4 -1.1 0.5
Ever depressed for a whole week 0.5 0.6 2.0 0.1 -0.7 -1.4 -0.8 0.4 -0.3
Unable to work because of sickness or disability 1.2 1.6 3.6 -0.5 -0.6 -1.5 -1.3 1.9 1.2
Commuting to job workplace: Cycle 0.1 0.2 0.5 0.4 -0.0 -0.3 0.7 0.3 -0.4
Myopia 0.4 0.6 1.1 1.0 0.5 0.9 -0.3 -0.8 0.9
Vascular/heart problems diagnosed by doctor 1.4 3.8 9.3 -1.3 -2.6 -0.9 -3.1 1.4 -1.5
Cholesterol lowering medication 0.2 0.4 0.8 -0.6 -0.8 -0.1 -0.5 0.3 0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.6 -0.2 -0.2 -0.3 1.1 1.3 -0.3
Pain experienced in last month 0.4 0.7 2.6 -0.3 0.9 0.5 1.6 -0.3 -0.7
Supplements: Calcium 1.5 1.7 3.0 1.4 -1.1 -1.5 -1.7 1.4 0.0
Basal cell carcinoma (self-reported) 2.4 2.8 8.1 0.8 0.2 1.7 2.8 0.2 2.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.5 -0.1 0.1 0.7 0.6 0.2 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.0 -1.7 -1.4 -1.5 -0.1 -0.7 -0.0
Heart disease (siblings) 2.1 2.6 8.4 -0.1 -0.6 0.2 2.4 1.0 -2.9
Alcohol drinker status: Previous 1.6 1.8 5.9 -0.1 0.8 1.7 -0.1 -2.4 1.3
Pack years of smoking 1.0 1.4 3.4 0.9 1.1 -0.4 1.8 1.7 -0.0
Impedance of whole body 0.1 0.5 1.1 -0.7 -0.6 0.8 -1.1 0.0 -0.2
Leg fat mass (left) 0.1 0.2 1.0 -0.3 0.5 -0.2 0.1 -1.0 -0.4
Arm predicted mass (left) 0.1 0.4 1.3 1.1 0.6 0.1 0.8 0.2 0.2