Hub : Genes

TNNT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1380	0.0330	2.1e-05	0.026	0.034	0.084	0.068	0.066	3.3e-04	5.1e-05	2.2e-10	1.0e-08	1.8e-08
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1670	0.0560	4.8e-03	0.001	NA	0.035	NA	0.007	2.8e-01	NA	5.2e-03	NA	1.2e-01
3	GTEx	Skin Sun Exposed Lower leg	0.2610	0.0640	3.5e-05	0.096	NA	0.055	NA	0.089	2.6e-08	NA	2.3e-05	NA	8.5e-08
4	NTR	Blood	0.1804	0.0213	0.0e+00	0.175	0.148	0.169	0.173	0.179	6.1e-54	2.9e-45	3.1e-52	1.5e-53	1.6e-55
5	TCGA	Breast Invasive Carcinoma	0.0233	0.0123	4.6e-03	0.004	0.006	0.005	NA	0.002	4.2e-02	1.4e-02	2.3e-02	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.1	-0.5	0.6	0.7	0.7
Bipolar Disorder or Schizophrenia	0.9	2.3	5.4	1.5	-1.2	-0.4	2.3	1.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	-0.1	0.8	-0.3	-0.6	-0.4
Depression (Nagel 2018)	0.7	1.0	5.0	0.2	2.2	0.0	-0.3	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	0.9	1.0	-0.0	0.1	0.7
Neuroticism (Nagel 2018)	0.3	0.7	2.5	-0.4	1.6	0.7	0.1	0.4
Schizophrenia (2018)	1.5	3.1	5.1	2.1	-1.3	-0.9	2.2	1.9
Schizophrenia vs Biploar Disorder	0.3	0.5	2.2	0.0	0.0	0.0	0.0	1.5
Worry (Nagel 2018)	0.5	1.0	2.5	-0.2	0.8	1.6	0.4	1.2
Alzheimer’s Disease (in mother)	1.2	1.4	4.6	2.1	0.4	-1.2	0.8	0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.7	-0.5	0.3	0.9	0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	4.6	2.1	-0.9	-1.4	0.9	0.2
Crohns Disease (2017)	0.7	1.4	3.1	-1.7	-0.1	1.0	-1.5	-0.9
Irritable Bowel Disease (IBD)	0.6	1.4	2.6	-0.8	-1.2	-0.6	-1.6	-1.4
Ulcerative Colitis (UC)	0.6	1.1	1.7	-0.1	-1.2	-1.3	-1.1	-1.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.5	3.1	-1.2	0.6	0.5	-1.8	-1.5
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.3	0.1	0.6	-0.0	-0.1	-0.0
Breast Cancer	3.1	7.4	15.0	-1.4	-2.5	-1.4	-3.5	-3.9
Ovarian Cancer	0.1	0.1	0.5	-0.2	-0.7	0.2	0.3	-0.2
Prostate Cancer	1.4	2.0	4.6	-2.1	1.5	1.3	-0.7	1.0
Age at First Birth	0.3	0.4	1.6	-0.2	-0.2	-0.6	-0.4	-1.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	3.0	0.8	-0.6	-0.1	-0.4	-1.7
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.9	3.0	-1.1	0.5	1.7	0.0	0.0
Mean Putamen Volume	0.6	0.6	1.3	0.9	1.2	-1.0	0.1	0.1
Fasting Glucose	0.9	1.1	2.4	0.4	1.2	1.5	1.2	0.2
HbA1C	0.9	1.0	3.3	1.8	0.2	-0.6	-0.3	-1.1
HDL Cholesterol	0.4	0.6	1.3	-0.7	1.2	-0.0	-0.8	0.8
LDL Cholesterol	1.4	2.2	4.8	-1.4	-0.2	0.1	-2.0	-2.2
Lupus	0.4	0.6	1.4	-0.1	0.6	1.2	1.1	-0.5
Neuroticism (2016)	0.3	0.4	0.8	0.3	0.4	-0.7	0.6	0.9
Primary Biliary Cirrhosis	0.6	0.9	2.9	-0.7	-1.7	-0.7	0.4	-0.8
Rheumatoid Arthritis	0.5	0.7	2.3	-0.3	-0.0	0.3	1.1	1.5
Schizophrenia (2014)	1.1	2.5	5.9	2.4	-1.1	-0.9	1.8	1.1
Triglycerides	0.2	0.3	0.8	0.6	-0.4	-0.2	-0.6	-0.9
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.0	0.0	0.0	0.0	0.6
Ulcerative Colitis	1.1	1.6	5.3	-0.9	-1.2	-0.7	0.0	-2.3
Blood Eosinophil Count	0.0	0.3	0.4	-0.4	-0.6	-0.5	0.4	0.6
Blood Platelet Count	1.2	14.3	43.0	-4.8	1.3	-1.3	-6.6	-1.2
Blood Red Count	0.1	1.4	6.3	0.5	-0.5	0.3	2.5	-0.1
Blood White Count	0.7	5.5	12.5	0.8	1.6	1.6	3.1	3.5
Heel T-Score	0.1	0.9	3.8	0.3	0.8	-1.9	0.3	0.1
BMI	0.3	1.8	5.2	0.6	-0.1	0.8	2.3	1.7
Height	0.2	4.0	8.2	-1.8	0.7	2.9	-1.7	-2.3
Waist Hip Ratio (WHR)	0.7	2.9	10.8	0.4	-1.2	1.4	3.3	0.7
Systolic Blood Pressure	0.2	0.9	2.3	-0.7	-1.1	0.5	0.2	-1.5
Smoking Status	0.2	0.4	0.8	-0.9	-0.5	0.5	-0.3	-0.9
Allergy or Eczema	0.9	2.4	5.7	0.9	1.0	0.4	2.2	2.4
Cardiovascular Disease	0.3	0.9	2.3	0.5	-1.1	-0.7	-1.5	-0.5
Hypothyroidism (self reported)	0.4	0.8	1.7	-0.9	-1.2	-0.2	-0.4	-1.3
Respiratory disease	0.7	1.6	3.7	-1.3	-0.4	0.9	-1.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	0.4	0.8	0.8	-0.4	1.1
Lung FEV1/FVC ratio	0.5	2.4	9.3	0.0	-3.0	-1.5	0.5	-0.5
Lung FVC	0.2	0.8	1.3	-0.1	-1.0	-1.1	0.7	-1.1
Neuroticism	0.5	1.2	2.9	-0.9	1.7	1.4	0.0	0.2
Chronotype (morning person)	0.8	1.8	3.9	0.9	0.9	0.8	2.0	1.8
Hair Pigment	0.0	0.1	0.1	-0.4	0.3	0.3	-0.3	0.1
Tanning	0.0	0.3	1.2	0.5	0.1	0.2	1.1	0.4
Hand grip strength (left)	0.1	0.3	1.0	-1.0	0.1	-0.2	-0.1	-0.7
Number of treatments/medications taken	0.7	1.3	5.4	2.3	-0.3	-0.6	-0.9	0.1
Average weekly spirits intake	0.6	0.8	1.9	0.5	0.4	0.7	1.4	1.0
Sensitivity / hurt feelings	0.2	0.3	0.9	0.2	0.4	0.4	0.9	0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.0	-0.1	2.0	0.9	0.4	0.5
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.2	0.2	0.3	0.2	-0.0
Relative age of first facial hair	0.6	1.3	3.8	1.9	-0.1	-0.7	1.1	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.9	-0.6	0.9	-0.2	-0.0
Ever used hormone-replacement therapy (HRT)	1.5	2.0	6.3	2.5	0.4	-1.3	0.5	1.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.4	-0.4	0.2	-0.2	-1.2	-1.0
Systolic blood pressure, automated reading	0.2	0.5	1.1	-0.2	0.6	0.9	0.4	-1.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.7	1.3	-0.2	0.2	1.7	1.9
Angina	0.1	0.2	0.5	0.4	0.2	0.3	-0.4	0.7
Medication for hormone replacement therapy	1.0	1.1	2.9	1.4	-0.5	-1.7	0.2	0.4
Vitamin and mineral supplements	1.1	1.5	5.0	-1.2	-0.3	-0.5	-2.2	-0.7
Supplements: Zinc	0.2	0.3	0.8	0.2	-0.5	0.0	-0.9	-0.5
Medication: Co-codamol	2.1	2.4	5.0	1.8	-2.2	-1.5	0.9	-0.9
Medication: Metformin	0.2	0.3	0.4	0.6	0.6	0.4	-0.0	0.6
Diabetes (father)	0.7	0.9	3.1	0.1	-0.0	1.1	1.8	0.4
Diabetes (mother)	0.9	1.1	4.8	-0.7	-0.2	0.3	-2.2	0.0
Severe depression (siblings)	0.2	0.2	0.8	0.4	-0.0	-0.3	0.9	0.3
Pack years adult smoking proportion	0.4	0.6	2.2	0.1	0.8	1.5	-0.0	-0.1
Impedance of leg (right)	0.1	0.4	0.8	0.7	-0.9	-0.6	-0.2	-0.3
Leg fat-free mass (left)	0.0	0.2	0.4	0.1	-0.4	0.5	0.7	0.5
Trunk fat percentage	0.6	2.4	4.0	2.0	-1.7	-0.4	1.7	1.4
Hand grip strength (right)	0.4	1.0	2.7	-1.6	-0.4	0.1	-1.0	-1.2
Townsend deprivation index at recruitment	0.8	1.2	2.5	0.6	0.7	-0.4	1.6	1.6
Current tobacco smoking	0.1	0.2	0.7	0.1	0.4	0.8	0.6	-0.1
Average weekly fortified wine intake	0.1	0.1	0.2	0.2	0.2	0.2	-0.4	-0.3
Maternal smoking around birth	1.1	1.6	3.1	1.8	-0.4	-1.4	1.5	0.8
Fed-up feelings	0.0	0.1	0.1	0.1	-0.3	-0.4	-0.3	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	0.9	1.2	-0.5	0.6	0.3
Relative age voice broke	0.1	0.1	0.3	0.3	-0.2	-0.6	0.1	0.2
Taking other prescription medications	0.4	0.7	1.5	0.4	-1.2	0.1	-1.2	-0.4
Age when periods started (menarche)	0.2	0.6	2.0	1.4	-0.7	-0.3	0.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.8	-0.3	1.9	0.4	-0.4	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	7.7	1.6	-0.2	-2.8	0.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	1.1	-0.7	0.3	0.5	-0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.8	-1.3	-0.5	0.0	-0.9	0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.8	0.2	0.5	0.3	0.1
High blood pressure	0.1	0.3	1.1	1.1	-0.5	0.2	0.2	0.2
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.4	0.0	1.6	1.3	2.0	2.7
Multivitamins +/- minerals	0.9	1.2	4.4	0.7	0.2	0.8	2.1	0.6
Stomach or abdominal pain in last month	1.5	1.9	4.4	2.1	-0.6	-1.4	0.7	1.5
Supplements: Glucosamine	1.3	1.7	3.5	0.2	-1.1	-1.1	-1.9	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.4	0.7	-1.5	-0.9	0.6	0.1
Medication: Atenolol	1.2	1.5	3.8	0.0	0.7	1.4	1.1	1.9
Medication: Levothyroxine sodium	0.3	0.6	1.6	-0.7	-1.3	0.0	-0.4	-0.7
Sitting height	0.3	2.0	6.3	-1.4	0.5	0.8	-0.8	-2.5
Chronic bronchitis/emphysema (father)	1.2	1.4	4.1	1.4	-0.9	-2.0	-0.1	-0.2
High blood pressure (mother)	0.4	0.6	1.4	0.6	-1.2	-0.6	0.5	0.6
Body mass index (BMI)	0.4	1.6	3.7	0.8	-0.6	0.4	1.9	1.7
Impedance of leg (left)	0.0	0.2	0.6	-0.0	0.1	0.1	-0.8	-0.6
Leg predicted mass (left)	0.0	0.2	0.4	-0.0	-0.4	0.6	0.5	0.5
Trunk fat mass	0.4	1.8	3.0	1.6	-1.6	-0.1	1.7	0.9
Waist circumference	0.7	2.5	5.9	1.5	-1.4	0.6	2.4	1.4
Number of incorrect matches in round	0.8	1.4	4.2	2.0	-0.4	-1.3	0.6	0.6
Past tobacco smoking	0.8	1.5	4.5	0.9	2.1	0.4	0.4	1.4
Alcohol usually taken with meals	0.4	0.6	1.1	0.6	-0.7	-0.8	1.1	0.8
Nervous feelings	0.4	0.7	2.1	-0.6	0.7	1.4	0.2	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.8	-0.3	1.7	1.4	1.4	2.2
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.1	0.9	-0.1	-0.5	-0.6
Hair/balding pattern: Pattern 2	0.9	1.2	3.5	1.9	0.2	-1.1	1.0	-0.2
Had menopause	1.0	1.3	2.7	0.4	-1.2	-0.7	-1.2	-1.6
Had other major operations	0.7	0.9	1.6	1.3	-0.9	-0.5	-0.6	-1.2
Forced vital capacity (FVC)	0.7	2.5	6.7	-0.8	-1.1	-1.4	-1.5	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.2	2.5	-0.2	-2.5	1.1	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.0	0.7	1.0	-0.1	1.2	1.4
Qualifications: None of the above	1.2	2.5	4.9	-1.9	-0.5	0.0	-2.2	-1.9
Financial difficulties in last 2 years	0.3	0.4	1.7	-0.1	-0.0	0.1	-1.3	-0.5
Mouth/teeth dental problems	0.6	0.9	1.6	-0.8	0.9	0.3	1.1	-1.3
Heart attack	0.1	0.1	0.2	0.5	-0.2	-0.2	-0.5	-0.2
Allergy	0.8	1.8	3.3	0.4	-1.5	-1.6	-0.7	-1.8
Pain all over the body in last month	0.4	0.4	1.3	0.0	-0.2	-0.9	-0.1	-1.1
Diabetes (self-reported)	0.1	0.2	0.7	0.8	-0.1	-0.1	-0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	0.9	0.5	0.6	0.7	0.9
Medication: Ramipril	1.8	2.3	6.7	-0.1	-0.2	1.8	1.3	2.6
Medication: Simvastatin	1.0	1.5	2.5	1.4	-0.4	-1.6	-1.3	-1.0
Fluid intelligence score	0.3	0.5	1.3	1.1	-0.0	-0.5	1.0	0.4
Illnesses of siblings	0.1	0.2	0.5	-0.6	0.1	0.1	0.0	-0.7
Neuroticism score	0.6	1.3	3.5	-1.2	1.1	1.9	0.5	-0.1
Weight	0.1	0.6	1.5	0.6	-0.6	0.6	1.2	0.7
Impedance of arm (right)	0.5	2.2	6.1	2.5	-1.1	-1.7	0.1	0.7
Arm fat percentage (right)	0.7	2.6	4.0	1.9	-1.2	-0.3	2.0	1.9
Trunk fat-free mass	0.1	0.7	2.0	-0.8	0.6	1.4	0.3	-0.5
Hip circumference	0.1	0.5	1.1	0.8	-1.1	0.0	0.6	0.7
Time employed in main current job	2.0	2.4	9.0	1.3	0.2	-0.2	3.0	1.1
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.3	-0.3	0.7	0.0	0.5
Father’s age at death	0.9	1.2	2.7	-0.6	0.7	-0.3	-1.6	-1.6
Worrier / anxious feelings	0.2	0.3	0.6	0.7	-0.4	-0.3	-0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.3	0.9	0.6	0.3	0.3
Falls in the last year	2.0	2.7	8.7	3.0	-1.0	-0.8	0.9	1.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.1	-1.2	-0.4	0.8	-0.0
Number of live births	0.6	0.8	2.9	0.4	-1.7	-0.5	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.2	-0.7	-1.2	-1.6	-0.8	-1.8
Pulse rate	0.8	1.4	3.4	0.9	-0.9	1.1	1.8	0.9
Happiness	0.6	0.7	1.3	0.7	1.1	0.3	0.9	1.2
Noisy workplace	0.4	0.5	0.7	-0.9	0.6	0.4	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.9	0.7	0.9	0.8	0.9	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.2	-0.7	-0.5	-0.3	0.0
Mouth/teeth dental problems: Dentures	0.6	1.0	2.5	0.7	-1.3	-0.5	-1.6	-0.3
Asthma	0.6	1.2	3.2	-1.0	-0.2	0.5	-1.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.0	-0.4	1.0	-0.0	-0.0	0.2
Medication: Cholesterol lowering	0.3	0.4	1.3	0.4	-0.3	-0.8	-1.1	-0.1
Depression (self-reported)	0.3	0.3	1.0	1.0	0.1	0.4	0.3	-0.6
Medication: Lansoprazole	0.4	0.5	1.3	1.1	-0.6	-0.6	-0.6	-0.2
Prospective memory result	2.5	3.0	7.2	-2.0	0.3	-0.5	-2.7	-1.9
Lung cancer (father)	0.7	0.9	2.2	-0.2	0.8	1.5	1.1	0.6
Illnesses of mother	0.5	0.7	1.0	-1.0	0.9	0.9	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	5.0	-1.2	-0.5	-1.1	-1.1	-2.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.2	0.4	0.6	0.6	0.5
Impedance of arm (left)	0.3	1.5	3.0	1.7	-1.2	-1.6	-0.6	-0.1
Arm fat mass (right)	0.4	1.5	2.9	1.2	-0.9	0.3	1.7	1.5
Trunk predicted mass	0.1	0.7	2.2	-0.8	0.7	1.5	0.3	-0.4
Standing height	0.1	1.1	3.7	-0.3	-0.0	0.5	-1.1	-1.9
Length of working week for main job	0.7	0.7	1.2	0.8	-0.1	0.9	1.0	1.1
Exposure to tobacco smoke at home	1.7	1.9	4.3	-0.8	2.1	2.0	0.4	0.3
Breastfed as a baby	0.4	0.6	2.2	1.5	0.1	-0.5	0.4	-0.3
Tense / ‘highly strung’	1.0	1.7	2.8	1.2	1.0	1.0	1.7	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.4	1.0	1.6	0.7	0.6	-0.1
Hair/balding pattern: Pattern 4	0.6	1.5	3.0	-1.7	0.2	1.2	-1.2	-1.2
Birth weight of first child	0.3	0.5	2.0	-1.4	0.6	0.2	-0.2	0.2
Peak expiratory flow (PEF)	0.6	1.3	2.3	-0.9	-1.5	-1.5	-0.8	-0.9
Pulse wave reflection index	0.1	0.2	0.5	0.3	0.7	-0.5	-0.3	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	0.8	0.1	-0.5	-0.6	0.3
Loud music exposure frequency	0.6	0.7	1.5	0.2	0.9	0.1	-0.9	1.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.3	0.4	0.1	-0.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.2	-1.0	-0.4	-0.1	-1.5	-0.1
Blood clot in the leg (DVT)	0.6	0.8	2.4	-1.1	0.2	0.7	-1.5	0.1
Medication: Paracetamol	0.6	1.0	2.2	1.5	0.4	-1.4	-0.4	-0.7
Headache pain in last month	0.4	0.8	1.5	-0.9	-1.2	-0.9	-0.9	0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	-1.2	0.9	0.6	-0.1	-0.1
Glaucoma (self-reported)	0.6	0.7	2.3	0.4	-1.5	-0.5	-1.0	-0.1
Gout (self-reported)	2.1	2.8	7.9	-2.8	0.7	1.1	-2.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	-0.6	-1.6	-1.0	-0.5	-1.2
Medication: Amlodipine	1.0	1.4	3.4	-0.0	1.8	1.8	0.1	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.4	-0.3	0.8	0.7	-1.5	-0.1
Birth weight	0.2	0.4	1.1	0.6	0.5	0.2	1.1	0.6
Chronic bronchitis/emphysema (mother)	2.3	2.6	6.7	1.4	-2.6	-2.1	0.3	-0.2
High blood pressure (siblings)	0.3	0.5	1.0	0.3	-1.0	-0.2	0.7	0.8
Forced vital capacity (FVC), Best measure	0.7	2.6	8.3	-1.1	-0.1	-1.2	-1.5	-2.9
Body fat percentage	0.6	2.4	4.0	1.8	-1.5	-0.1	2.0	1.5
Leg fat percentage (right)	0.7	2.5	5.4	1.6	-1.5	0.1	2.3	1.4
Arm fat-free mass (right)	0.1	0.5	1.0	-0.9	0.2	1.0	-0.0	-1.0
Exposure to tobacco smoke outside home	0.2	0.3	0.4	-0.6	-0.6	-0.4	-0.4	-0.6
Comparative body size at age 10	1.8	5.0	9.7	1.7	1.9	-0.1	2.9	3.1
Number of full brothers	1.4	1.7	5.2	-0.2	-0.7	-1.0	-2.3	-1.4
Worry too long after embarrassment	1.6	2.7	4.9	-1.4	2.0	2.2	0.8	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.4	-0.1	-0.7	-0.7	-0.6	-1.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.4	0.6	0.2	-0.1	0.6
Number of children fathered	2.2	2.5	6.5	-0.6	-0.4	-0.8	-2.5	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.2	0.2
Age at first live birth	0.2	0.4	1.7	-0.2	-1.3	-0.1	0.6	-0.3
Pulse wave peak to peak time	0.3	0.4	0.6	-0.3	-0.5	-0.7	-0.7	-0.8
Health satisfaction	1.6	2.0	4.4	2.1	0.3	0.4	1.9	1.4
Shortness of breath walking on level ground	1.5	1.8	6.0	2.4	0.4	-1.2	-0.4	1.1
Qualifications: College or University degree	0.5	1.5	4.6	1.1	-0.2	0.2	2.1	1.3
Eye problems/disorders: None of the above	0.6	0.7	1.2	-0.8	-0.9	-0.4	-0.9	-1.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	5.4	-0.8	0.4	-0.1	-2.3	-0.7
Emphysema/chronic bronchitis	0.5	0.5	1.5	1.2	1.0	0.1	0.3	-0.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.5	-1.6	-1.4	0.9	1.4	0.1
Neck or shoulder pain in last month	0.5	0.7	1.7	0.1	1.2	0.3	0.2	1.3
Medication: Blood pressure	0.4	0.7	2.6	1.6	-0.3	0.4	0.9	0.4
Angina (self-reported)	0.2	0.3	0.6	0.4	0.2	0.6	-0.2	0.8
Migraine (self-reported)	0.8	1.0	2.7	-1.6	0.5	0.8	-1.1	-0.8
Medication: Ibuprofen	0.4	0.5	1.4	0.4	1.2	-0.5	0.5	0.5
Medication: Allopurinol	0.8	1.1	2.7	-1.6	0.2	0.7	-1.5	0.5
Medication: Omeprazole	0.7	0.9	1.7	1.1	-0.6	0.2	1.3	0.9
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.0	0.6	0.2	0.0	-0.3
Mean time to correctly identify matches	0.5	1.0	2.0	-1.1	0.1	-0.4	-1.4	-1.2
Heart disease (mother)	0.4	0.4	1.3	0.3	1.1	0.3	-0.3	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.5	-0.5	-1.6	-1.5	-0.6	-1.1
Whole body fat mass	0.5	2.1	4.3	1.6	-1.4	0.0	2.1	1.2
Leg fat mass (right)	0.7	2.5	5.4	1.7	-1.7	-0.1	2.3	1.3
Arm predicted mass (right)	0.1	0.7	1.2	-1.1	0.1	1.0	-0.4	-1.1
Pulse rate, automated reading	0.3	1.0	2.0	0.1	-0.2	1.0	1.4	1.3
Alcohol intake frequency.	0.3	0.7	1.6	-0.1	0.7	1.3	1.0	0.5
Comparative height size at age 10	0.0	0.2	0.6	0.8	-0.6	0.1	0.2	-0.0
Number of full sisters	0.3	0.4	0.8	-0.9	-0.6	0.2	0.3	0.8
Suffer from ‘nerves’	0.9	1.4	2.7	-1.5	1.4	1.6	0.4	0.4
Overall health rating	0.4	0.8	1.7	1.0	-1.3	-0.7	-0.7	-0.6
Chest pain or discomfort	2.8	4.1	9.5	3.1	1.6	-0.9	2.0	2.0
Had major operations	0.8	0.9	2.2	1.5	0.1	-0.5	0.7	1.2
Age at last live birth	0.3	0.4	1.0	-0.3	-1.0	0.8	0.6	-0.2
Family relationship satisfaction	0.4	0.5	0.7	0.8	0.5	-0.8	0.4	0.8
Leg pain on walking	2.3	2.9	5.7	2.4	-0.9	-1.7	2.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	2.0	-0.2	-0.7	1.1	0.7
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.3	-0.6	-1.6	-0.0	-2.1	-1.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.9	-0.8	-0.3	-0.6	-1.0
Medication: Aspirin	1.1	1.5	3.6	1.9	1.4	-0.7	-1.2	0.2
Supplements: Vitamin C	0.8	1.0	2.2	0.7	0.2	-0.3	1.5	1.5
Knee pain experienced in last month	0.4	0.6	1.7	-0.3	-1.3	-0.7	-0.6	-0.5
Hypertension (Self-reported)	0.1	0.2	0.7	0.8	-0.4	0.5	-0.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	3.6	0.1	-1.9	-1.6	-1.8	-1.0
Illnesses of father: Heart disease	0.8	1.1	3.6	0.6	1.9	0.9	0.3	0.9
Illnesses of siblings: Diabetes	1.8	2.2	4.4	0.5	1.8	1.6	0.6	2.1
Smoking status: Previous	1.1	1.6	5.1	-0.4	-2.3	-0.9	-0.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.4	-0.0	-1.6	-0.3	-1.2	-2.3
Whole body fat-free mass	0.1	0.4	1.5	-0.6	0.4	1.2	0.3	-0.1
Leg fat-free mass (right)	0.1	0.3	1.1	-0.5	0.4	1.0	0.3	0.4
Arm fat percentage (left)	0.5	2.1	3.5	1.8	-1.2	-0.2	1.9	1.6
Average weekly red wine intake	0.7	1.0	2.5	0.4	-0.9	-0.8	-1.0	-1.6
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.5	0.5	-0.9	-1.4	-1.6	-1.3
Mood swings	0.1	0.2	0.5	0.7	0.3	-0.4	0.3	-0.5
Loneliness, isolation	1.7	2.3	4.1	-1.8	2.0	1.8	0.8	0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.8	0.7	-0.6	0.6	-0.9	-0.9
Ever had bowel cancer screening	0.6	0.7	2.2	1.5	-0.3	-0.6	0.8	0.2
Diabetes diagnosed by doctor	0.2	0.4	1.0	1.0	-0.7	-0.5	-0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	0.5	-0.4	0.5	-0.5
Friendships satisfaction	1.0	1.3	2.0	1.3	0.9	0.5	1.4	1.3
Qualifications: nursing, teaching	0.3	0.5	1.3	-0.3	0.9	0.0	0.8	1.1
Commuting to job workplace: Walk	0.5	0.6	1.3	1.1	1.0	-0.4	0.5	0.4
Eye problems/disorders: Cataract	0.3	0.3	1.1	-0.2	-1.0	-0.4	-0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.7	0.6	-0.6	0.2	0.6	1.6
Medication for cholesterol	0.1	0.2	0.4	-0.2	-0.4	-0.3	0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.6	1.6	-1.1	-0.7	0.3	0.7
Back pain experienced in last month	0.3	0.5	1.4	0.4	0.5	0.4	-1.2	0.6
Mineral and other dietary supplements	0.7	0.9	2.6	-0.8	0.5	0.9	0.6	1.6
Breast cancer (self-reported)	0.4	0.5	1.1	-0.3	-0.4	0.7	-1.0	-0.7
Asthma (self-reported)	0.6	1.1	2.8	-1.2	-0.3	0.5	-1.7	-1.1
Osteoporosis (self-reported)	1.6	2.0	2.9	-1.4	0.8	1.5	-1.5	-1.7
Osteoarthritis (self-reported)	0.6	0.8	2.1	0.9	-1.5	-0.9	0.4	-0.5
Medication: Aspirin	1.1	1.4	4.5	2.1	1.2	-0.5	-0.9	0.3
Medication: Gliclazide	0.0	0.0	0.1	0.3	-0.1	0.1	-0.1	-0.1
Illnesses of father: None of the above (group 1)	1.4	1.8	4.3	-1.3	-0.7	-0.3	-2.1	-1.5
Smoking status: Current	0.2	0.3	0.6	0.2	0.8	0.8	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.4	-0.5	-1.9	-2.1	-0.9	-1.6
Whole body water mass	0.1	0.4	1.3	-0.6	0.2	1.1	0.2	-0.2
Leg predicted mass (right)	0.1	0.3	1.1	-0.5	0.4	1.1	0.3	0.4
Arm fat mass (left)	0.3	1.3	2.3	1.3	-1.0	0.2	1.5	1.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.0	1.1	-0.7	0.1	-1.4	-0.9
Average weekly champagne plus white wine intake	1.9	2.5	6.2	2.1	0.2	0.1	2.5	1.4
Miserableness	0.1	0.2	0.5	0.4	-0.7	-0.6	0.2	0.4
Guilty feelings	1.9	2.8	6.2	-2.1	2.5	1.7	0.6	0.2
Wears glasses or contact lenses	0.8	0.9	2.0	1.2	0.6	-1.4	-0.4	-0.7
Ever taken oral contraceptive pill	0.9	1.0	3.8	-0.2	2.0	0.7	0.2	0.7
Hearing aid user	0.5	0.5	1.8	1.4	-0.4	-0.6	0.4	0.4
Mother’s age at death	0.2	0.2	0.6	0.8	-0.5	-0.3	0.4	-0.2
Financial situation satisfaction	1.4	1.8	4.0	-0.5	1.7	2.0	0.7	1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.6	-1.0	-0.1	0.9	0.3
Commuting to job workplace: Public transport	0.6	0.7	1.5	-1.2	0.7	1.1	0.5	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	-0.0	-1.0	0.2	-0.6	0.4
Medication: Blood pressure	0.1	0.2	0.4	-0.2	-0.2	0.6	-0.2	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.7	-0.7	-0.2	0.2	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	0.7	0.1	-0.5	-0.6	-0.4
High cholesterol (Self-reported)	0.9	1.5	6.1	0.1	0.6	-0.6	-2.5	-0.9
Medication: Bendroflumethiazide	0.6	0.9	1.8	1.3	-1.4	-1.0	0.1	-0.0
Medication: Paracetamol	0.8	1.2	4.6	2.1	0.5	-1.2	0.1	-0.1
Medication: Lisinopril	0.6	0.8	2.6	1.6	0.2	-0.7	0.9	0.4
Medication: Atorvastatin	0.7	0.9	2.8	-1.7	0.0	0.9	-1.0	-0.2
Illnesses of father: High blood pressure	0.8	1.0	1.8	-0.7	0.5	1.4	1.0	1.1
Alcohol drinker status: Never	0.5	0.6	1.0	-0.7	0.6	1.0	-0.2	-1.0
Ever smoked	0.7	1.2	2.1	-1.4	-1.3	0.4	-0.5	-1.3
Basal metabolic rate	0.1	0.3	1.1	-0.3	0.1	1.1	0.5	0.1
Leg fat percentage (left)	0.4	1.6	3.9	1.0	-0.8	0.6	2.0	1.4
Arm fat-free mass (left)	0.1	0.6	1.6	-0.9	0.6	1.3	-0.0	-0.4
Number of operations (self-reported)	0.8	1.2	5.1	2.3	-0.3	-0.7	-0.6	-0.3
Average weekly beer plus cider intake	1.0	1.5	2.8	-1.6	1.7	1.3	-0.1	0.5
Irritability	0.9	1.5	4.6	-0.3	2.2	1.5	0.8	0.3
Risk taking	0.9	1.3	3.3	-0.2	0.7	-0.5	1.8	1.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.1	0.7	-1.4	-0.6	-0.5	-0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.6	-0.2	-1.3	-0.1	-0.6	-0.7
Age started oral contraceptive pill	0.7	0.9	2.4	1.6	-0.5	-0.9	0.8	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.7	-0.0	0.3	0.8	0.6	-0.4
Ever depressed for a whole week	0.6	0.7	1.5	0.8	1.2	-0.1	1.0	-0.6
Unable to work because of sickness or disability	0.4	0.6	1.9	1.4	0.8	-0.5	-0.1	0.0
Commuting to job workplace: Cycle	0.2	0.2	0.8	-0.9	-0.5	-0.1	-0.1	0.3
Myopia	1.1	1.6	5.7	0.7	0.0	-0.5	2.4	1.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.3	-1.5	-0.1	-0.3	-0.5	-0.4
Cholesterol lowering medication	0.7	1.0	3.8	0.4	-0.3	-0.9	-1.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.5	1.2	-0.8	0.0	1.0	0.5
Pain experienced in last month	0.6	1.0	2.2	1.3	0.1	-0.3	1.5	1.1
Supplements: Calcium	1.2	1.3	3.8	0.4	-1.2	-0.9	-0.7	-1.9
Basal cell carcinoma (self-reported)	1.1	1.3	5.0	0.4	2.2	1.2	-0.2	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.3	0.2	0.0	-0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.5	-1.1	-0.1	0.4	-1.6	-0.1
Heart disease (siblings)	0.5	0.6	1.4	0.2	1.2	0.4	-0.1	1.2
Alcohol drinker status: Previous	0.6	0.7	1.7	0.3	-1.3	-0.4	1.3	-0.1
Pack years of smoking	0.4	0.6	2.2	0.3	0.9	1.5	-0.2	-0.2
Impedance of whole body	0.2	0.8	1.1	1.1	-0.8	-1.1	-0.9	-0.5
Leg fat mass (left)	0.4	1.6	3.9	1.1	-1.3	0.2	2.0	1.2
Arm predicted mass (left)	0.2	0.8	1.9	-1.2	0.5	1.4	-0.4	-0.5