Hub : Genes

TOMM20

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0994	0.0332	2.1e-04	0.069	NA	0.025	NA	0.043	4.6e-06	NA	4.3e-03	NA	2.4e-04
2	GTEx	Muscle Skeletal	0.1107	0.0361	3.8e-04	0.001	NA	0.021	NA	0.010	2.2e-01	NA	3.1e-03	NA	3.4e-02
3	GTEx	Nerve Tibial	0.0862	0.0315	4.8e-04	0.042	NA	0.057	NA	0.049	5.6e-04	NA	7.0e-05	NA	2.1e-04
4	METSIM	Adipose	0.0468	0.0198	8.4e-03	0.002	0.010	0.010	0.013	0.009	1.2e-01	9.3e-03	9.4e-03	3.5e-03	1.4e-02
5	YFS	Blood	0.0822	0.0225	4.3e-07	0.053	0.029	0.046	0.050	0.050	9.7e-17	5.6e-10	7.7e-15	6.3e-16	3.9e-16
6	TCGA	Bladder Urothelial Carcinoma	0.0520	0.0260	2.5e-04	-0.002	0.010	-0.002	NA	-0.002	5.7e-01	4.5e-02	5.3e-01	NA	5.2e-01
7	TCGA	Breast Invasive Carcinoma	0.0191	0.0130	3.8e-03	0.003	0.008	0.000	NA	0.005	6.5e-02	8.3e-03	4.1e-01	NA	2.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.3	0.7	0.2	0.8	0.5	0.0	-0.4	-0.7	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.6	1.6	-0.9	1.1	-0.4	0.2	-0.5	-0.5	-1.3
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	-0.6	-1.1	0.1	-1.1	1.2	-1.1	1.1
Depression (Nagel 2018)	1.0	1.5	4.7	-0.9	-0.5	0.3	-1.6	1.4	-2.2	0.2
Intelligence (Savage-Jansen 2018)	1.1	3.4	10.2	-2.0	-1.6	-3.2	1.4	0.6	1.4	-1.5
Neuroticism (Nagel 2018)	0.8	1.9	4.9	-0.3	-2.1	0.4	-2.2	0.8	-1.5	0.9
Schizophrenia (2018)	0.3	0.7	1.6	-1.3	0.9	-0.9	0.5	-0.5	0.1	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.6	1.6	0.9	0.5	1.3	0.3	0.4	-0.1	1.1
Worry (Nagel 2018)	1.0	2.0	5.9	0.8	-0.5	1.7	-2.4	-0.3	-1.6	1.4
Alzheimer’s Disease (in mother)	2.0	2.3	9.1	1.1	1.3	1.0	1.3	-3.0	1.0	-0.8
Alzheimer’s Disease (in father)	1.2	1.2	2.8	-1.1	0.9	-1.7	1.0	1.2	1.2	0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	4.0	0.3	1.9	0.2	2.0	-1.5	1.2	-0.4
Crohns Disease (2017)	0.9	2.1	5.9	-1.1	-2.4	-0.7	-0.9	0.3	-2.2	-0.9
Irritable Bowel Disease (IBD)	0.6	1.5	3.9	-1.2	-1.5	-1.0	-0.0	1.3	-2.0	-0.2
Ulcerative Colitis (UC)	0.5	0.9	2.9	-0.7	0.1	-1.0	0.7	1.7	-1.1	0.6
Major Depression (MDD)	2.5	3.0	4.9	-2.2	-1.9	-1.4	-1.0	-1.1	-2.0	-2.2
Reaction Time	0.5	0.9	2.1	1.0	1.1	0.7	-0.4	1.0	0.5	1.4
Verbal and Numeric Reasoning (VNR)	0.8	2.0	5.4	-0.8	-1.7	-2.3	0.7	-0.9	1.6	-1.1
Breast Cancer	0.2	0.6	2.2	1.5	-0.1	0.8	0.1	-0.5	0.5	0.8
Ovarian Cancer	0.9	1.2	3.7	1.5	-0.1	1.4	-0.3	-1.9	-0.2	0.2
Prostate Cancer	0.1	0.2	0.4	0.1	-0.5	-0.6	-0.1	0.2	-0.4	-0.3
Age at First Birth	0.9	1.3	3.2	1.8	-0.1	1.7	-0.9	-0.9	-0.9	0.8
Bipolar Disorder (2011)	0.8	0.8	2.7	0.6	1.6	-0.4	0.7	-1.2	0.0	0.0
Body Mass Index (BMI) (2010)	1.1	1.5	3.5	-1.9	1.2	-1.7	0.7	1.6	0.0	0.0
Coronary Artery Disease (CAD)	0.2	0.3	0.6	0.2	-0.7	-0.8	0.4	0.8	0.0	0.0
Crohns Disease (2012)	1.3	2.1	11.3	-1.4	-3.4	-0.9	-0.5	-0.4	0.0	0.0
Mean Putamen Volume	1.0	1.2	2.5	1.1	1.1	0.6	1.6	-1.0	1.0	0.9
Fasting Glucose	0.4	0.4	1.3	-0.7	0.5	-1.2	0.1	-0.9	-0.2	-0.3
HbA1C	0.9	1.1	3.4	1.2	0.8	1.1	-0.3	-0.3	0.7	1.8
HDL Cholesterol	0.5	0.8	3.1	0.9	-0.2	0.8	-1.8	-0.3	-0.8	0.6
LDL Cholesterol	0.4	0.7	1.4	-0.8	-0.9	-1.2	0.2	1.0	0.2	-0.8
Lupus	4.5	6.8	14.6	-3.8	-0.9	-3.5	-0.1	3.6	-1.5	-2.0
Neuroticism (2016)	1.1	1.5	3.6	-1.6	-0.3	-1.9	-0.3	1.7	-0.0	-1.2
Primary Biliary Cirrhosis	0.7	1.0	2.4	-1.5	-0.7	-1.6	0.4	0.8	-0.2	-0.8
Rheumatoid Arthritis	1.2	1.6	3.7	1.5	0.6	1.8	-1.1	-0.6	-0.2	1.9
Schizophrenia (2014)	0.3	0.7	2.7	0.1	1.1	0.6	0.5	-1.6	-0.1	-0.4
Triglycerides	0.1	0.2	0.8	0.1	-0.9	0.4	-0.1	0.7	-0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.9	0.1	-1.0	-0.1	-0.6	0.2	0.0	0.0
Ulcerative Colitis	1.1	1.5	3.2	-1.2	-0.1	-1.4	1.8	1.7	-1.1	0.2
Blood Eosinophil Count	0.7	5.2	12.2	-3.5	-2.2	-2.0	1.4	1.6	-2.2	-2.4
Blood Platelet Count	1.0	12.0	26.9	-5.2	-3.4	-3.8	0.2	-1.0	-1.7	-5.2
Blood Red Count	0.3	3.4	7.0	2.6	0.6	1.6	0.9	-2.1	2.1	2.0
Blood White Count	0.4	2.8	11.8	0.6	-1.9	1.1	-3.4	-1.5	0.0	0.5
Heel T-Score	0.9	7.3	23.7	3.9	0.4	4.9	-1.5	-1.3	-1.0	2.6
BMI	0.4	2.6	5.4	-2.3	0.1	-2.2	1.8	0.7	-0.7	-1.9
Height	1.3	24.8	69.2	-5.0	1.7	-8.3	6.0	4.1	4.5	-1.6
Waist Hip Ratio (WHR)	0.2	0.8	2.3	1.2	0.6	0.2	1.5	0.2	-0.2	1.3
Systolic Blood Pressure	0.3	1.4	3.2	-1.3	-0.2	-1.8	1.3	1.3	0.3	-1.1
Smoking Status	0.9	2.1	4.0	1.7	0.0	1.8	-1.7	0.8	-1.2	2.0
Allergy or Eczema	0.2	0.5	2.5	-0.0	-0.7	-0.5	-1.6	0.5	0.4	0.3
Cardiovascular Disease	0.4	1.4	3.3	-1.4	-1.8	-1.5	-0.3	0.5	-0.5	-1.3
Hypothyroidism (self reported)	3.4	7.8	19.0	-4.4	1.1	-4.0	1.8	2.4	-0.7	-3.0
Respiratory disease	1.0	2.1	5.9	-2.4	-0.9	-2.3	0.5	0.0	-0.5	-1.5
Type 2 Diabetes (T2D) (2018)	1.7	3.2	8.4	-2.0	-1.7	-2.9	0.3	2.6	0.4	-0.2
Lung FEV1/FVC ratio	0.9	4.8	15.1	2.1	3.9	1.2	0.7	-1.7	2.7	1.4
Lung FVC	0.2	1.2	6.2	0.8	0.3	-0.2	-0.2	-2.5	0.7	-1.2
Neuroticism	0.5	1.1	2.5	-0.1	-1.1	0.4	-1.6	0.8	-1.0	1.5
Chronotype (morning person)	0.2	0.5	0.8	-0.9	0.9	-0.2	0.5	-0.9	0.0	-0.8
Hair Pigment	0.1	3.2	9.1	2.0	-0.0	0.7	3.0	-1.7	1.6	1.9
Tanning	0.2	2.1	4.7	-0.3	-2.2	0.2	-1.0	-1.7	-1.6	-1.8
Hand grip strength (left)	0.6	1.5	4.5	-0.2	0.7	-1.1	1.4	-2.1	0.7	-1.4
Number of treatments/medications taken	1.6	2.8	8.0	-1.9	-0.8	-1.6	-1.1	2.8	-1.6	-0.8
Average weekly spirits intake	0.3	0.4	1.9	0.1	1.4	-0.5	0.5	0.4	0.0	-0.4
Sensitivity / hurt feelings	0.7	1.2	3.9	-0.6	-1.0	0.7	-1.5	0.7	-2.0	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.6	-1.1	0.1	0.1	-0.2	0.9	-1.3	-0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.5	0.3	0.7	0.8	-1.2	-0.7	-0.6	-0.0
Relative age of first facial hair	0.9	1.8	4.6	1.7	0.2	2.1	-0.0	-1.9	-0.9	0.9
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.5	-2.5	-0.4	-2.5	0.8	0.5	-0.5	-2.0
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.7	-1.0	-0.2	-0.5	-0.9	1.6	0.0	-0.1
Ever had hysterectomy (womb removed)	0.8	0.9	1.9	-1.4	-0.1	-0.9	1.1	0.6	0.1	-1.4
Systolic blood pressure, automated reading	0.4	1.1	2.8	-1.3	0.6	-1.7	0.6	0.9	-0.7	-1.1
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	6.3	-0.6	-0.0	-1.2	0.8	2.5	0.8	1.2
Angina	0.8	1.0	4.3	-0.4	0.1	-0.1	1.2	2.1	-0.5	0.9
Medication for hormone replacement therapy	0.9	1.0	2.2	-1.4	-0.2	-1.2	-0.5	1.5	-0.1	-1.0
Vitamin and mineral supplements	0.2	0.2	1.3	0.3	-0.3	-0.1	0.2	-1.1	0.2	0.3
Supplements: Zinc	0.3	0.3	0.7	-0.4	-0.0	-0.9	-0.7	0.7	0.6	-0.2
Medication: Co-codamol	0.2	0.2	0.6	-0.5	-0.8	-0.2	-0.4	0.2	0.5	-0.3
Medication: Metformin	0.9	1.3	4.2	-1.0	0.2	-1.7	0.7	2.1	-0.0	0.5
Diabetes (father)	1.0	1.2	5.9	-0.0	-0.9	-0.3	0.7	2.4	-0.7	0.8
Diabetes (mother)	0.5	0.7	3.1	-0.3	0.1	-0.1	0.4	0.2	-1.8	-1.2
Severe depression (siblings)	1.2	1.4	4.1	-1.5	-0.1	-0.7	-0.4	0.4	-2.0	-1.5
Pack years adult smoking proportion	0.9	1.4	3.1	-1.2	-1.8	-1.7	1.0	1.0	-0.6	0.1
Impedance of leg (right)	1.2	6.0	13.1	3.4	0.5	3.6	-2.0	-1.0	0.8	3.3
Leg fat-free mass (left)	1.9	10.0	24.4	-4.1	-0.2	-4.9	4.2	1.3	0.3	-3.1
Trunk fat percentage	0.3	1.4	3.3	-1.0	0.8	-1.0	1.6	1.8	-0.9	-0.5
Hand grip strength (right)	0.8	2.1	5.6	-1.1	0.4	-2.4	1.5	-1.1	1.6	-1.4
Townsend deprivation index at recruitment	1.5	2.1	5.6	2.4	0.7	2.1	-1.0	-0.4	0.1	1.6
Current tobacco smoking	0.6	1.0	2.4	-0.5	-1.1	-0.3	-0.7	1.6	-1.5	0.4
Average weekly fortified wine intake	0.6	0.8	2.1	-1.2	0.3	-1.0	-0.0	0.4	-0.6	-1.4
Maternal smoking around birth	0.3	0.5	0.9	0.1	0.3	0.8	0.9	-0.9	-0.9	0.3
Fed-up feelings	0.8	1.5	4.6	0.1	-0.7	0.6	-1.9	1.1	-0.2	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.5	-0.9	-0.1	0.5	-1.9	1.9	-2.1	0.4
Relative age voice broke	0.3	0.5	1.2	0.8	-0.1	1.0	-0.4	-0.1	-0.4	1.1
Taking other prescription medications	0.9	1.4	4.6	-1.5	0.0	-1.3	-0.4	2.1	-0.6	-0.9
Age when periods started (menarche)	0.1	0.2	0.4	-0.5	-0.3	0.4	-0.6	0.3	0.2	0.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.0	-2.0	-0.3	-1.7	0.4	1.6	0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	7.8	2.8	1.3	2.3	-0.4	-1.1	1.0	1.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	-1.0	-1.1	-0.6	-0.6	1.4	-0.8	-0.1
Qualifications: CSEs or equivalent	0.6	0.8	1.8	1.2	-0.5	1.4	0.6	-1.2	0.1	-0.0
Serious illness, injury or assault to yourself	0.2	0.3	0.6	0.5	0.8	0.6	-0.4	-0.3	-0.3	0.4
High blood pressure	0.4	1.2	2.7	-1.2	-1.0	-1.6	-0.1	1.3	-0.3	-1.1
Hayfever, allergic rhinitis or eczema	0.4	1.0	5.4	-0.2	-0.8	-0.5	-2.3	0.5	0.3	-0.1
Multivitamins +/- minerals	0.3	0.4	1.3	0.7	0.8	1.2	0.1	-0.4	-0.3	0.2
Stomach or abdominal pain in last month	1.1	1.4	3.0	-1.3	-1.7	-0.5	-0.8	0.7	-1.4	-1.3
Supplements: Glucosamine	0.9	1.2	4.2	-1.3	-1.1	-2.1	0.2	0.6	0.6	-0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	-0.9	-1.4	-0.3	0.4	1.2	-0.7	-0.7
Medication: Atenolol	0.2	0.2	0.7	0.3	0.2	0.8	0.1	-0.7	0.4	0.2
Medication: Levothyroxine sodium	3.1	5.2	14.0	-3.7	1.0	-3.1	1.3	1.9	-0.3	-2.4
Sitting height	0.8	5.6	13.0	-1.7	2.5	-3.6	2.0	1.8	3.1	-0.5
Chronic bronchitis/emphysema (father)	1.4	1.6	4.2	1.4	0.7	1.3	0.7	1.3	-0.8	2.0
High blood pressure (mother)	1.4	2.0	7.0	-1.3	-0.8	-0.3	-0.1	0.7	-2.6	-1.9
Body mass index (BMI)	0.5	2.0	4.2	-1.6	-0.6	-1.2	1.5	0.8	-2.1	-1.6
Impedance of leg (left)	1.0	4.8	10.2	2.9	0.7	3.1	-2.1	0.0	0.6	3.2
Leg predicted mass (left)	1.9	10.2	24.8	-4.1	-0.2	-5.0	4.2	1.3	0.2	-3.2
Trunk fat mass	0.7	3.2	6.9	-2.0	0.8	-2.3	2.6	2.1	-0.6	-1.0
Waist circumference	0.8	3.0	7.7	-1.8	0.4	-2.2	2.8	1.3	-1.4	-1.3
Number of incorrect matches in round	3.2	5.4	12.4	3.5	0.4	3.3	-2.0	-2.3	0.5	2.1
Past tobacco smoking	0.6	1.2	2.7	-1.1	-0.6	-1.5	1.2	-0.6	0.1	-1.6
Alcohol usually taken with meals	0.7	1.2	3.3	-1.4	0.4	-1.8	-0.4	-0.9	0.4	-1.3
Nervous feelings	1.4	2.6	5.2	1.2	-0.7	2.3	-2.2	-1.0	-1.8	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.6	-0.2	-0.1	-0.5	0.8	-1.0	0.2
Hearing difficulty/problems with background noise	0.8	1.3	3.8	-2.0	-0.6	-1.4	-0.5	0.7	-1.1	-0.9
Hair/balding pattern: Pattern 2	1.7	2.2	6.4	1.4	-0.6	2.5	-1.4	-0.5	-1.2	1.7
Had menopause	1.8	2.3	5.8	-2.4	0.3	-1.8	0.3	1.3	-0.8	-2.1
Had other major operations	1.2	1.4	5.8	-1.2	-0.5	-1.0	-2.4	0.6	-0.8	-0.7
Forced vital capacity (FVC)	1.6	6.2	14.9	-0.5	1.7	-3.2	3.1	-2.2	3.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	10.8	3.3	1.4	2.6	-0.8	-0.1	0.7	3.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	7.7	0.6	0.4	1.0	-2.8	0.4	-1.3	0.9
Qualifications: None of the above	0.3	0.7	2.1	1.3	0.1	0.7	0.6	0.5	0.2	1.5
Financial difficulties in last 2 years	2.2	3.0	8.0	2.8	1.0	1.7	1.4	-0.7	1.1	2.3
Mouth/teeth dental problems	0.8	1.2	2.5	1.4	-1.6	0.7	1.1	-1.4	0.9	0.2
Heart attack	0.5	0.7	2.2	-0.1	-0.0	0.2	-1.0	1.1	-1.5	0.6
Allergy	0.6	1.4	4.4	1.0	2.1	0.5	1.7	-0.5	0.8	0.8
Pain all over the body in last month	0.3	0.3	1.1	0.2	-0.3	0.5	0.2	1.0	-0.3	0.6
Diabetes (self-reported)	1.1	1.7	4.7	-1.2	-1.1	-2.0	0.2	2.2	0.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	5.0	0.4	1.4	0.9	-2.2	-0.2	0.2	1.0
Medication: Ramipril	0.3	0.4	1.5	0.0	-0.3	0.6	0.9	0.1	-1.2	-0.0
Medication: Simvastatin	2.0	2.9	6.8	-2.0	-1.6	-2.6	0.6	-0.0	-0.4	-2.5
Fluid intelligence score	0.7	1.4	3.4	-1.3	-1.0	-1.8	0.4	-0.1	0.8	-1.7
Illnesses of siblings	0.2	0.3	1.1	0.3	-1.0	-0.3	0.6	-0.5	0.4	-0.0
Neuroticism score	0.5	1.0	2.3	0.1	-0.9	0.9	-1.5	0.5	-1.1	1.3
Weight	1.4	7.1	17.1	-3.5	-0.2	-4.1	3.3	1.7	-0.7	-2.5
Impedance of arm (right)	0.4	1.9	3.6	1.9	1.2	1.5	-0.4	-0.3	1.8	1.6
Arm fat percentage (right)	0.2	0.9	3.6	-0.5	0.4	-0.5	1.9	0.4	-1.0	-0.8
Trunk fat-free mass	1.6	9.4	26.0	-4.0	-1.0	-5.1	3.8	1.0	0.3	-2.8
Hip circumference	1.0	4.1	7.7	-2.6	0.2	-2.7	2.8	1.0	-0.9	-2.3
Time employed in main current job	0.4	0.4	1.0	-0.9	-0.2	-0.3	0.6	0.8	-1.0	-0.4
Alcohol intake versus 10 years previously	0.3	0.4	1.1	0.2	1.1	0.9	-0.2	-0.1	-0.8	0.5
Father’s age at death	0.8	1.1	3.6	0.6	1.9	0.1	0.3	-0.3	1.6	1.0
Worrier / anxious feelings	0.4	0.7	1.8	-1.2	-0.1	-1.3	-0.4	0.3	0.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.6	-1.4	-1.4	-0.7	-0.9	2.1	-1.5	-0.3
Falls in the last year	0.3	0.4	1.2	-0.2	-0.6	0.4	-0.3	1.1	-0.8	0.6
Hair/balding pattern: Pattern 3	0.5	0.8	3.6	-0.2	1.1	-0.3	1.9	0.5	0.4	0.4
Number of live births	1.5	2.2	5.1	-0.5	-0.9	1.0	-2.2	-1.5	-1.8	-1.7
Forced expiratory volume in 1-second (FEV1)	2.2	7.6	17.2	-0.7	2.2	-3.5	3.3	-2.4	4.1	-1.2
Pulse rate	0.1	0.2	0.6	0.4	-0.1	-0.5	0.8	0.1	-0.4	-0.1
Happiness	1.4	1.7	5.0	0.5	1.4	1.3	-2.2	-0.2	-1.5	0.6
Noisy workplace	1.5	1.8	5.3	1.4	1.1	1.3	0.9	1.1	0.8	2.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.9	-0.3	1.9	-1.1	1.1	0.4	2.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.9	-0.0	1.7	0.4	0.5	0.2	-0.5	-0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	3.3	-0.6	-0.3	0.5	-1.7	0.2	-1.8	-0.1
Asthma	1.3	2.6	5.4	-2.3	-1.7	-2.2	0.1	0.8	-0.9	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	-0.1	-1.0	-0.1	-0.0	-0.4	-0.6	-0.3
Medication: Cholesterol lowering	0.5	0.8	2.4	-1.1	-0.2	-1.5	-0.4	1.0	-0.8	-0.4
Depression (self-reported)	0.1	0.1	0.4	-0.6	0.0	-0.7	0.4	-0.1	-0.1	0.3
Medication: Lansoprazole	0.6	0.7	2.0	-0.3	0.1	-1.4	0.4	0.2	1.3	-0.9
Prospective memory result	0.3	0.3	0.9	0.5	-1.0	0.7	-0.8	0.1	0.1	-0.2
Lung cancer (father)	0.5	0.6	2.2	0.6	0.2	-0.3	1.5	0.7	0.3	1.0
Illnesses of mother	0.8	1.0	3.7	0.3	1.0	-1.0	-0.3	0.1	1.2	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	18.8	0.0	2.2	-2.2	2.7	-1.9	4.3	-0.1
Pulse wave Arterial Stiffness index	0.9	1.1	1.9	-1.1	1.4	-0.8	1.0	1.4	-1.0	0.3
Impedance of arm (left)	0.3	1.6	3.6	1.4	1.2	1.0	-0.5	0.6	1.9	1.5
Arm fat mass (right)	0.7	2.9	6.6	-2.0	-0.1	-2.1	2.6	1.1	-1.3	-1.7
Trunk predicted mass	1.7	9.6	26.7	-4.0	-0.9	-5.2	3.7	1.0	0.3	-2.9
Standing height	1.4	14.2	42.4	-4.5	0.8	-6.5	4.4	2.0	2.8	-2.2
Length of working week for main job	0.8	0.9	2.6	-0.1	-0.5	0.8	0.6	-1.3	-1.6	-0.9
Exposure to tobacco smoke at home	1.2	1.4	7.5	-0.4	0.3	0.2	0.1	2.7	-0.8	1.1
Breastfed as a baby	0.6	0.8	2.9	-0.0	1.0	-1.0	0.7	0.5	1.7	-0.0
Tense / ‘highly strung’	0.9	1.5	3.2	1.1	-0.9	1.0	-1.6	-1.0	-1.8	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	6.1	-0.5	-0.8	0.1	-2.5	-0.1	-2.3	-0.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	-0.8	0.3	-1.7	0.6	0.4	1.3	-1.0
Birth weight of first child	0.3	0.6	1.8	0.5	1.3	0.3	0.6	-1.2	0.1	0.0
Peak expiratory flow (PEF)	2.6	6.1	16.0	-1.0	1.4	-3.6	2.5	-1.8	4.0	-1.3
Pulse wave reflection index	0.1	0.2	0.7	-0.4	0.2	0.3	-0.8	0.3	-0.3	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	0.1	0.0	-0.2	-1.0	1.3	-0.3	0.6
Loud music exposure frequency	1.8	2.0	6.6	0.0	0.9	0.0	-1.6	2.6	-0.4	1.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.9	0.4	-0.3	-0.1	0.6	-0.7	1.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	-1.2	0.8	-0.2	-0.1	0.9	-1.4	0.1
Blood clot in the leg (DVT)	1.0	1.3	6.1	0.5	-0.6	1.1	-0.3	-2.5	-0.6	-0.9
Medication: Paracetamol	0.2	0.4	1.1	-0.4	0.3	0.1	0.7	1.1	-0.7	0.5
Headache pain in last month	0.3	0.5	1.2	-0.4	-0.7	-0.0	1.1	1.1	0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.9	0.7	0.7	0.4	1.3	-0.5	1.7	0.8
Glaucoma (self-reported)	0.3	0.4	1.4	-0.5	-1.2	0.3	-0.5	-0.3	-0.5	-0.5
Gout (self-reported)	0.5	0.6	1.9	-0.7	0.9	-1.1	-0.1	1.4	0.3	-0.0
Hypothyroidism/myxoedema (self-reported)	2.2	4.4	10.9	-3.3	0.5	-3.0	1.2	2.2	-0.4	-1.9
Medication: Amlodipine	1.6	2.3	5.2	-2.1	-1.1	-1.0	-0.5	0.5	-2.3	-1.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-1.3	-0.7	-0.6	0.0	0.3	0.1	-0.8
Birth weight	0.8	1.7	3.7	-0.3	1.8	-1.7	1.5	0.1	1.9	-0.2
Chronic bronchitis/emphysema (mother)	2.1	2.4	8.5	-0.4	1.6	-0.5	1.3	2.9	1.3	1.4
High blood pressure (siblings)	0.4	0.5	1.7	0.3	0.7	1.1	-1.3	-0.2	-0.4	0.0
Forced vital capacity (FVC), Best measure	1.0	3.8	12.6	-0.2	1.2	-2.3	2.3	-1.4	3.5	-0.1
Body fat percentage	0.2	0.7	1.6	-0.3	0.6	-0.1	1.2	1.3	-1.1	-0.1
Leg fat percentage (right)	0.2	0.8	2.6	0.8	0.1	1.3	0.3	0.1	-1.6	0.6
Arm fat-free mass (right)	1.6	8.3	21.4	-3.9	-0.8	-4.6	3.2	1.6	-0.3	-2.8
Exposure to tobacco smoke outside home	1.3	1.8	4.7	2.1	0.0	2.2	-0.4	-0.0	-1.6	0.9
Comparative body size at age 10	0.4	1.2	3.2	-1.5	1.0	-0.7	0.4	0.6	-1.8	-0.8
Number of full brothers	0.1	0.1	0.3	-0.2	-0.1	0.1	-0.4	-0.5	0.2	-0.1
Worry too long after embarrassment	0.2	0.4	1.9	-0.3	-1.4	-0.1	-0.4	0.3	-0.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.1	0.3	-0.1	-0.8	0.7	-0.8	0.2
Wheeze or whistling in the chest in last year	1.1	2.0	7.6	-0.9	-0.8	-0.8	0.8	2.8	-1.7	0.6
Number of children fathered	1.9	2.2	5.7	0.5	1.3	0.3	2.3	-2.4	1.5	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.7	-0.5	-0.4	-0.2	-1.3	-0.3	-0.3	-0.8
Age at first live birth	0.3	0.6	2.4	0.5	-0.3	0.3	0.3	-1.6	1.1	0.3
Pulse wave peak to peak time	0.7	0.8	1.8	0.8	-1.4	0.4	-0.6	-1.0	1.1	-0.3
Health satisfaction	1.0	1.3	5.2	0.3	1.0	0.0	-0.8	1.5	-0.2	2.3
Shortness of breath walking on level ground	0.6	0.7	2.9	-0.8	-0.7	-0.8	0.2	1.7	-0.3	-0.2
Qualifications: College or University degree	1.0	3.2	7.8	-2.7	0.3	-2.8	0.6	0.8	0.2	-2.5
Eye problems/disorders: None of the above	0.6	0.6	3.8	0.4	-0.2	0.2	-0.6	-2.0	0.0	-0.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.2	-0.9	0.1	-0.8	-0.7	1.5	-1.1	0.6
Emphysema/chronic bronchitis	0.7	0.7	1.9	-1.1	-0.9	-0.6	0.8	1.4	-0.2	0.1
Medication for pain relief, constipation, heartburn	0.6	1.1	2.8	-0.7	0.0	-1.4	1.1	-0.5	1.7	-0.9
Neck or shoulder pain in last month	0.6	0.8	2.4	0.2	1.1	-0.1	-0.2	1.2	-0.8	1.5
Medication: Blood pressure	0.2	0.3	1.4	-0.6	-0.2	-0.4	-0.3	0.2	-1.2	-0.5
Angina (self-reported)	0.7	0.9	3.8	-0.2	-0.2	0.2	1.0	2.0	-0.7	0.9
Migraine (self-reported)	0.5	0.6	2.1	0.4	0.9	-0.2	0.6	0.9	0.3	1.4
Medication: Ibuprofen	0.1	0.1	0.3	-0.0	-0.5	-0.3	-0.1	-0.4	-0.1	-0.2
Medication: Allopurinol	0.2	0.3	1.1	-0.2	0.5	-0.2	-1.1	0.8	0.0	0.0
Medication: Omeprazole	0.9	1.0	2.3	-1.3	0.9	-1.2	0.3	0.2	-1.0	-1.5
Medication: Seretide 50 evohaler	1.7	1.9	4.5	-1.7	-2.1	-1.3	0.9	1.4	-1.1	-0.4
Mean time to correctly identify matches	0.5	0.9	2.2	0.6	1.1	0.5	-0.7	1.5	-0.0	1.3
Heart disease (mother)	0.6	0.8	2.0	0.5	-1.4	1.3	0.2	-0.7	-0.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.6	-0.7	-0.7	-0.4	0.1	0.4	-0.5
Whole body fat mass	0.5	2.2	5.0	-1.7	0.5	-1.8	2.2	1.3	-1.0	-1.2
Leg fat mass (right)	0.3	1.2	2.6	-1.1	0.4	-0.9	1.6	1.0	-1.4	-0.8
Arm predicted mass (right)	1.4	7.4	19.3	-3.7	-0.6	-4.4	3.0	1.4	-0.3	-2.6
Pulse rate, automated reading	0.9	2.7	6.2	-1.5	-2.4	-1.1	-0.8	1.1	-2.5	-1.4
Alcohol intake frequency.	0.4	0.9	2.8	-1.1	0.5	-0.9	0.9	1.7	-0.5	0.3
Comparative height size at age 10	1.3	7.0	18.6	-2.5	1.6	-4.3	3.7	1.4	2.0	-1.2
Number of full sisters	0.3	0.4	0.8	0.7	-0.1	0.7	0.9	-0.6	0.8	0.1
Suffer from ‘nerves’	1.7	2.7	5.4	0.5	-1.2	2.2	-2.3	-1.1	-2.1	1.1
Overall health rating	1.3	2.9	10.0	-1.6	-1.4	-0.9	-0.8	3.2	-2.0	0.0
Chest pain or discomfort	1.5	2.1	8.4	0.1	-1.9	0.9	-2.9	-0.0	-1.4	0.2
Had major operations	1.8	2.1	4.8	-1.6	-1.4	-0.8	-1.1	0.0	-2.2	-1.9
Age at last live birth	0.5	0.8	4.4	0.4	-0.7	0.4	-0.4	-2.1	-0.3	0.1
Family relationship satisfaction	0.5	0.6	1.8	1.1	0.5	0.8	-0.3	-0.0	-0.1	1.4
Leg pain on walking	0.2	0.3	1.2	-0.6	0.1	-0.3	-0.4	1.1	-0.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	4.1	2.0	-0.3	1.7	1.4	-0.3	0.1	2.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.5	0.4	-2.3	1.0	-0.7	-1.6	-0.8	-0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.6	-1.6	-0.8	-1.2	-1.2	0.9	-1.2	-0.8
Medication: Aspirin	1.5	2.0	6.5	0.8	-0.7	1.6	-2.5	0.4	-1.7	0.5
Supplements: Vitamin C	0.6	0.7	3.0	0.6	0.7	0.2	-1.7	-0.7	0.4	0.3
Knee pain experienced in last month	0.3	0.4	1.2	-0.5	1.1	-0.5	-0.5	0.8	-0.3	0.5
Hypertension (Self-reported)	0.7	2.1	4.2	-1.9	-1.0	-2.0	-0.5	1.7	-0.7	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.1	-1.3	1.2	-1.4	-0.4	0.5	-0.1	-1.2
Illnesses of father: Heart disease	0.1	0.2	0.5	0.6	-0.4	0.4	0.3	0.3	-0.1	0.7
Illnesses of siblings: Diabetes	0.6	0.8	2.2	-0.5	1.2	-1.2	0.1	1.5	0.3	0.4
Smoking status: Previous	0.8	1.1	2.5	1.2	0.8	1.6	-1.3	-0.0	-0.0	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	8.5	-1.0	2.0	-1.8	2.9	1.1	1.5	0.0
Whole body fat-free mass	1.8	10.5	27.9	-4.3	-0.7	-5.3	3.9	1.4	0.1	-3.1
Leg fat-free mass (right)	2.3	12.2	30.6	-4.6	-0.2	-5.5	4.1	1.9	0.1	-3.5
Arm fat percentage (left)	0.2	0.9	2.9	-0.7	0.4	-0.7	1.7	0.9	-1.0	-0.8
Average weekly red wine intake	0.7	1.1	6.0	0.3	0.6	0.2	-0.5	-2.4	0.5	-0.6
Handedness (chirality/laterality): Left-handed	1.5	1.8	6.9	1.4	-0.3	2.6	-0.3	-1.6	-1.0	0.2
Mood swings	1.0	1.7	6.0	0.1	-1.4	0.8	-2.4	0.2	-1.8	0.8
Loneliness, isolation	0.6	0.8	2.4	-1.2	-0.7	0.1	0.1	0.9	-1.6	-0.3
Long-standing illness, disability or infirmity	3.1	4.7	11.1	-3.3	0.2	-3.2	-0.4	2.6	-1.5	-1.6
Ever had bowel cancer screening	1.8	2.2	6.1	-1.2	-1.6	-0.6	-1.3	2.5	-1.8	0.3
Diabetes diagnosed by doctor	1.4	2.4	6.3	-1.3	-1.7	-2.3	0.6	2.5	-0.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.8	0.7	-0.7	0.0	-0.3	0.1	0.1	1.3
Friendships satisfaction	1.4	1.7	5.9	2.0	0.9	0.7	0.6	-0.1	0.7	2.4
Qualifications: nursing, teaching	0.8	1.3	4.0	-0.9	1.4	-1.0	-0.6	2.0	0.7	0.5
Commuting to job workplace: Walk	2.2	2.3	5.4	-1.6	1.2	-2.3	0.8	2.2	0.6	-1.0
Eye problems/disorders: Cataract	0.5	0.6	1.3	1.2	1.0	0.8	0.1	-0.7	0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	-0.2	1.6	-0.8	-1.8	0.4	1.8	0.3
Medication for cholesterol	1.6	2.4	4.7	2.2	0.8	2.0	0.4	-1.9	0.5	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.8	0.3	-0.1	-0.0	-0.3	0.9	0.1	0.3
Back pain experienced in last month	1.1	1.6	3.6	-1.8	0.0	-1.3	-1.0	0.1	-1.9	-1.3
Mineral and other dietary supplements	0.5	0.7	2.1	1.4	0.7	0.8	0.3	0.3	0.4	1.1
Breast cancer (self-reported)	1.2	1.4	2.8	-1.7	-1.2	-1.2	-0.9	1.5	-1.1	0.0
Asthma (self-reported)	1.4	2.7	5.7	-2.4	-2.0	-2.2	0.0	0.8	-1.0	-1.8
Osteoporosis (self-reported)	0.4	0.5	3.4	0.0	-1.9	-0.2	0.4	-0.2	0.3	0.1
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.0	0.9	-0.8	0.3	-0.5	0.9	0.7
Medication: Aspirin	1.1	1.5	6.2	0.4	-0.8	1.0	-2.5	0.6	-1.4	0.2
Medication: Gliclazide	1.3	1.5	3.7	-1.9	-0.6	-1.9	0.3	1.1	-0.9	-0.9
Illnesses of father: None of the above (group 1)	0.8	1.0	4.7	0.0	-0.6	0.7	-0.7	-2.2	-0.3	-1.0
Smoking status: Current	0.5	0.7	1.6	-0.7	-1.0	-0.6	-0.6	1.1	-1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	10.2	2.8	1.3	1.0	0.3	-3.2	2.4	1.5
Whole body water mass	1.9	10.7	27.9	-4.3	-0.7	-5.3	4.0	1.3	0.1	-3.2
Leg predicted mass (right)	2.3	12.0	30.0	-4.6	-0.2	-5.5	4.1	1.9	0.1	-3.5
Arm fat mass (left)	0.7	2.8	5.1	-2.0	-0.3	-2.1	2.3	1.3	-1.3	-1.6
Number of self-reported non-cancer illnesses	2.0	3.5	9.4	-2.3	-1.0	-2.5	-0.9	3.1	-0.7	-0.9
Average weekly champagne plus white wine intake	2.8	3.9	11.0	-2.8	-0.8	-2.6	-0.6	-0.5	0.4	-3.3
Miserableness	0.1	0.3	0.5	-0.6	-0.0	-0.6	-0.1	0.7	0.3	0.7
Guilty feelings	0.1	0.2	0.5	-0.6	0.1	-0.4	0.1	0.7	-0.2	0.3
Wears glasses or contact lenses	0.4	0.5	1.7	-0.9	-0.1	-0.3	-1.3	0.5	-0.2	-0.5
Ever taken oral contraceptive pill	0.7	0.8	2.0	0.6	-1.2	0.8	-0.9	0.6	-0.3	1.4
Hearing aid user	0.2	0.2	1.0	0.1	0.4	0.4	0.3	-1.0	0.3	0.3
Mother’s age at death	0.8	1.0	3.0	-0.7	1.2	-0.9	0.1	-0.5	1.7	-1.2
Financial situation satisfaction	1.0	1.2	2.5	1.4	0.3	1.6	-0.4	-1.4	-0.7	1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.5	0.3	-0.3	-1.0	0.5	-0.8	1.9	0.6
Commuting to job workplace: Public transport	0.6	0.8	1.6	-1.0	1.3	-1.0	0.3	1.1	0.5	-0.5
Eye problems/disorders: Glaucoma	1.1	1.3	2.6	-1.4	-1.6	-0.5	-0.4	0.0	-1.4	-1.6
Medication: Blood pressure	0.9	1.7	3.6	-1.9	-0.1	-1.9	-0.2	1.8	0.2	-1.2
Pain type(s) experienced in last month: Hip pain	2.3	2.8	7.2	-2.0	1.2	-2.7	1.3	2.3	-0.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	0.2	1.1	0.7	-0.5	-0.5	0.1	0.6
High cholesterol (Self-reported)	0.4	0.7	1.9	-0.4	-1.1	-0.8	-0.8	1.4	-0.3	-0.3
Medication: Bendroflumethiazide	1.1	1.7	4.3	-1.5	-2.1	-0.7	0.1	-0.0	-1.5	-1.6
Medication: Paracetamol	0.4	0.6	1.4	-0.9	0.2	-1.1	0.9	1.2	0.1	-0.2
Medication: Lisinopril	1.8	2.3	5.2	-2.2	0.3	-2.1	-1.0	2.3	-0.4	-0.8
Medication: Atorvastatin	0.8	1.0	4.3	-0.3	0.4	0.1	-1.1	2.1	-0.6	0.9
Illnesses of father: High blood pressure	0.8	1.0	2.9	-1.7	-0.0	-0.9	-0.8	1.2	-0.6	-0.7
Alcohol drinker status: Never	3.2	3.8	9.9	-2.8	-0.5	-2.4	1.2	-0.7	-0.9	-3.1
Ever smoked	0.3	0.5	1.2	0.5	-0.2	0.9	-1.1	0.7	-0.6	0.7
Basal metabolic rate	1.8	10.0	25.4	-4.2	-0.7	-5.0	3.9	1.5	-0.1	-3.1
Leg fat percentage (left)	0.2	0.7	3.2	0.3	0.2	0.9	0.3	0.8	-1.8	0.5
Arm fat-free mass (left)	1.3	6.8	17.5	-3.5	-1.0	-4.2	3.0	1.1	-0.6	-2.6
Number of operations (self-reported)	2.1	3.2	4.7	-2.1	-2.0	-2.2	-2.0	1.5	-1.4	-0.8
Average weekly beer plus cider intake	0.4	0.5	1.3	-0.0	-1.0	-1.0	0.6	0.0	1.1	-0.2
Irritability	0.6	1.0	3.5	-1.1	-0.9	-1.9	0.7	0.5	0.2	-0.7
Risk taking	0.5	0.7	1.9	-0.3	0.0	-0.9	1.2	-1.4	0.4	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	-0.1	0.4	-0.7	-0.1	0.7	0.7	0.7
Fractured/broken bones in last 5 years	3.0	3.9	8.0	-2.8	-2.2	-2.1	0.1	1.5	-1.4	-2.3
Age started oral contraceptive pill	0.4	0.6	2.3	-1.0	-0.3	-0.4	-0.3	-0.3	-0.4	-1.5
Diastolic blood pressure, automated reading	0.1	0.3	0.8	0.6	0.3	0.5	0.3	0.6	-0.9	0.6
Ever depressed for a whole week	0.8	1.0	2.9	-0.7	-0.9	0.3	-1.7	0.1	-1.7	-0.1
Unable to work because of sickness or disability	0.7	0.9	2.2	1.2	-0.2	0.1	0.7	1.2	0.9	1.5
Commuting to job workplace: Cycle	0.9	1.0	2.5	0.5	1.6	0.0	0.6	-1.6	1.3	-0.3
Myopia	1.0	1.4	6.7	-0.8	-1.1	-0.6	-2.6	0.7	-0.0	-0.6
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.6	1.2	0.8	1.6	0.1	-1.5	0.6	1.1
Cholesterol lowering medication	1.1	1.6	3.5	-1.5	-1.9	-1.8	-0.1	1.0	-0.0	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	3.8	-0.2	2.0	-0.1	0.4	-0.2	-1.0	-0.7
Pain experienced in last month	1.0	1.7	3.6	1.8	0.9	1.6	0.0	-1.9	1.3	0.2
Supplements: Calcium	1.3	1.4	4.0	-1.2	-1.0	-0.6	-2.0	0.7	-0.9	-1.3
Basal cell carcinoma (self-reported)	1.0	1.2	2.6	-0.4	1.1	-1.6	0.9	1.1	1.6	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.8	-0.2	-0.0	0.3	-1.0	0.9	-1.7	0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.6	0.3	-1.0	1.1	-0.4	-2.4	-1.1	-1.2
Heart disease (siblings)	0.4	0.5	0.9	-0.8	0.1	-1.0	0.6	0.6	0.9	-0.3
Alcohol drinker status: Previous	0.7	0.9	3.0	0.1	0.7	-0.1	-0.9	1.7	-0.2	1.3
Pack years of smoking	1.0	1.5	3.2	-1.4	-1.6	-1.8	0.9	1.3	-0.7	0.1
Impedance of whole body	0.6	3.3	6.3	2.4	1.0	2.3	-1.6	0.3	1.4	2.5
Leg fat mass (left)	0.4	1.6	2.8	-1.4	0.4	-1.3	1.7	1.3	-1.5	-0.9
Arm predicted mass (left)	1.2	6.3	15.8	-3.3	-1.1	-4.0	3.1	1.0	-0.4	-2.5