Hub : Genes

TOMM40L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0464 0.0208 3.7e-03 0.002 0.013 0.005 0.013 0.003 1.2e-01 4.3e-03 4.7e-02 4.2e-03 1.2e-01
2 YFS Blood 0.2169 0.0384 2.0e-15 0.020 0.064 0.073 0.065 0.046 3.0e-07 4.6e-20 7.0e-23 2.6e-20 5.8e-15
3 TCGA Glioblastoma Multiforme 0.1550 0.0800 7.5e-03 0.083 -0.005 -0.010 NA 0.005 1.7e-03 5.0e-01 9.0e-01 NA 2.2e-01
4 TCGA Brain Lower Grade Glioma 0.0422 0.0225 1.1e-03 0.010 0.024 0.010 NA 0.011 2.4e-02 7.7e-04 2.0e-02 NA 1.7e-02
5 TCGA Pheochromocytoma and Paraganglioma 0.1640 0.0760 6.7e-03 0.065 0.008 0.041 NA 0.047 1.4e-03 1.5e-01 9.8e-03 NA 6.0e-03
6 TCGA Testicular Germ Cell Tumors 0.1630 0.0690 2.2e-03 0.026 0.021 0.016 NA 0.022 4.2e-02 6.1e-02 8.9e-02 NA 5.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 2.7 4.3 11.6 0.6 -0.9 -3.4 -3.0 1.4 -1.4
Bipolar Disorder or Schizophrenia 1.8 4.4 10.3 1.2 -1.0 -3.2 -2.6 1.6 -2.1
Depressed Affect (Nagel 2018) 0.2 0.4 1.6 1.2 -0.4 -0.1 -0.1 -0.2 -0.6
Depression (Nagel 2018) 1.6 2.5 4.4 1.2 -1.1 2.1 2.1 -1.4 -1.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 2.0 -0.1 -0.4 -0.2 -0.7 1.4 1.1
Neuroticism (Nagel 2018) 0.3 0.6 1.0 0.9 -1.0 -0.7 -0.8 0.5 -0.9
Schizophrenia (2018) 0.6 1.2 2.3 1.0 -0.6 -1.4 -0.9 0.9 -1.5
Schizophrenia vs Biploar Disorder 1.2 1.6 3.4 0.5 -0.5 1.7 1.2 -1.9 1.0
Worry (Nagel 2018) 0.5 1.0 2.4 -0.3 -1.1 -0.6 -0.4 1.3 -1.5
Alzheimer’s Disease (in mother) 1.3 1.5 4.8 -0.7 -0.4 -2.2 -1.2 0.8 -1.2
Alzheimer’s Disease (in father) 1.2 1.3 2.6 -0.6 -1.5 -0.7 -1.5 1.6 -0.2
Alzheimer’s Disease (including proxy) 1.9 2.8 5.9 -0.8 -0.8 -2.4 -1.5 1.9 -1.8
Crohns Disease (2017) 2.2 4.8 14.1 3.0 0.4 -1.6 -1.9 -3.8 0.3
Irritable Bowel Disease (IBD) 2.3 5.5 19.5 2.0 0.7 -1.9 -2.1 -4.4 -0.7
Ulcerative Colitis (UC) 1.6 3.1 10.4 0.1 1.0 -1.5 -1.5 -3.2 -1.6
Major Depression (MDD) 1.4 1.7 4.2 0.7 -0.2 2.1 1.7 -1.3 -0.9
Reaction Time 1.3 2.4 3.8 -1.4 -0.8 -1.9 -1.9 1.5 -1.4
Verbal and Numeric Reasoning (VNR) 1.2 3.0 5.8 -1.7 -1.3 -2.0 -1.7 2.4 -0.6
Breast Cancer 0.2 0.4 1.5 1.2 -0.3 -0.1 0.4 0.8 0.1
Ovarian Cancer 1.0 1.3 4.2 2.0 0.2 -0.9 -0.7 -1.2 0.8
Prostate Cancer 0.6 0.8 3.0 -0.1 -0.8 1.7 1.0 0.4 0.2
Age at First Birth 0.8 1.1 2.0 -0.0 -0.9 -1.3 -1.4 1.1 0.9
Bipolar Disorder (2011) 2.8 2.8 8.7 1.1 -0.8 -3.0 -1.8 1.4 -0.9
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 -0.6 -0.6 0.6 0.8 -0.6 -0.4
Coronary Artery Disease (CAD) 2.2 2.6 5.3 -1.5 0.0 -2.2 -1.4 2.3 -1.1
Crohns Disease (2012) 1.8 2.9 9.0 2.5 0.6 -0.9 -0.8 -3.0 0.1
Mean Putamen Volume 0.5 0.5 2.3 0.3 0.0 -0.0 -0.0 -0.9 1.5
Fasting Glucose 0.8 1.0 2.3 -1.5 -0.2 -0.9 -0.9 0.8 -1.2
HbA1C 0.7 0.8 3.3 -0.2 0.3 -1.1 -1.8 -0.2 0.4
HDL Cholesterol 1.5 2.6 7.2 -2.7 0.0 -0.6 -1.0 2.1 1.6
LDL Cholesterol 0.8 1.2 4.5 -2.1 -1.0 -0.2 -0.3 -1.1 -0.6
Lupus 1.3 2.0 8.2 2.9 -0.0 -0.6 0.7 1.3 -1.1
Neuroticism (2016) 0.5 0.7 1.9 1.4 -0.9 -0.5 -0.9 -0.8 0.0
Primary Biliary Cirrhosis 0.8 1.2 3.1 -0.5 1.0 1.8 1.6 0.2 0.2
Rheumatoid Arthritis 0.9 1.3 4.2 -1.4 -0.5 0.8 -0.4 -2.0 0.6
Schizophrenia (2014) 0.9 2.1 4.6 1.1 -0.0 -2.1 -1.1 1.7 -1.6
Triglycerides 1.1 1.8 8.5 0.2 -0.5 0.5 0.7 -2.9 -1.0
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.2 -1.4 -0.1 -1.5 -0.9 -0.3 -1.0
Ulcerative Colitis 1.5 2.1 6.7 1.6 0.8 -0.8 -0.6 -2.6 -1.4
Blood Eosinophil Count 1.2 9.0 23.7 -1.7 -3.2 2.9 -0.7 -4.9 2.8
Blood Platelet Count 0.6 6.9 18.7 -0.4 2.0 -4.3 -1.6 3.4 -2.0
Blood Red Count 0.7 6.5 19.4 -2.8 0.5 2.8 2.0 -4.4 0.3
Blood White Count 2.1 15.3 37.9 3.9 -0.8 4.8 2.9 -6.2 2.7
Heel T-Score 0.1 0.8 2.1 -1.3 -0.4 -0.4 -0.6 -0.5 -1.4
BMI 0.7 4.1 14.3 1.3 -0.0 2.1 3.8 -1.7 -1.1
Height 0.0 0.8 2.9 -0.3 1.0 -0.0 1.0 -0.4 -1.7
Waist Hip Ratio (WHR) 1.1 4.8 6.4 -1.6 1.6 -2.5 -2.4 2.2 -2.5
Systolic Blood Pressure 1.1 5.5 11.2 2.1 2.5 3.2 3.3 0.3 1.1
Smoking Status 0.3 0.7 2.9 0.8 -1.7 0.6 -0.0 -0.2 0.2
Allergy or Eczema 2.9 7.6 13.2 -3.4 -2.7 -0.4 -3.4 -1.3 3.6
Cardiovascular Disease 0.3 1.1 3.5 0.3 0.7 1.1 1.9 0.4 -1.2
Hypothyroidism (self reported) 0.4 0.9 3.1 1.8 0.2 0.4 1.3 0.7 0.3
Respiratory disease 1.3 2.9 8.5 -1.7 1.3 1.4 -0.0 -2.9 1.5
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.0 1.1 0.3 0.2 1.4 -1.1 -0.7
Lung FEV1/FVC ratio 0.8 4.1 10.2 1.9 -2.0 -3.2 -2.5 -0.7 0.3
Lung FVC 0.1 0.6 2.5 -1.6 -0.4 -0.1 -0.6 0.7 -0.5
Neuroticism 0.3 0.7 1.7 1.2 -0.6 -0.7 -0.6 -0.3 -1.3
Chronotype (morning person) 1.3 3.1 6.2 -2.3 -1.6 -2.1 -2.5 -0.0 0.1
Hair Pigment 0.0 0.5 1.2 1.1 1.1 -0.7 0.2 -0.1 -0.6
Tanning 0.1 1.7 3.4 -1.0 -0.7 1.6 1.7 0.3 -1.8
Hand grip strength (left) 0.4 1.1 6.2 0.4 -0.4 0.3 0.4 -2.5 0.5
Number of treatments/medications taken 1.1 2.0 5.1 2.1 2.3 1.1 0.6 -0.8 -0.4
Average weekly spirits intake 0.2 0.2 0.7 0.0 -0.6 -0.2 -0.9 0.1 0.2
Sensitivity / hurt feelings 0.5 0.9 2.0 1.3 -0.4 -0.3 0.2 1.2 -1.4
Frequency of depressed mood in last 2 weeks 2.5 3.6 9.7 1.9 -1.1 2.0 1.5 -3.1 -0.7
Hearing difficulty/problems: Yes 1.1 1.7 4.4 0.9 0.4 2.0 2.1 -0.6 0.9
Relative age of first facial hair 0.4 0.9 2.2 0.6 -1.5 -1.2 -1.0 0.3 0.3
Other serious medical condition/disability diagnosed by doctor 2.3 3.0 5.0 1.4 1.4 2.2 2.1 -1.3 -1.9
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.6 1.1 -0.5 -0.4 0.6 -0.9 -1.3
Ever had hysterectomy (womb removed) 0.4 0.5 1.4 0.5 -0.4 -0.9 -0.4 -0.5 -1.2
Systolic blood pressure, automated reading 1.3 3.9 7.9 2.7 2.8 1.3 2.3 -0.6 1.0
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.6 0.6 -0.5 0.9 1.6 -1.9 -0.0
Angina 1.1 1.4 5.1 -0.7 2.3 1.6 0.6 0.3 0.2
Medication for hormone replacement therapy 0.5 0.5 1.8 0.4 -0.2 -0.1 -1.0 -1.4 0.0
Vitamin and mineral supplements 0.5 0.6 1.1 -0.4 1.1 1.0 0.9 0.5 -0.5
Supplements: Zinc 0.5 0.5 2.3 -0.2 -0.7 -1.5 -0.3 -0.1 0.6
Medication: Co-codamol 2.5 2.9 9.4 1.4 -0.5 1.6 1.7 -3.1 -0.6
Medication: Metformin 1.3 1.8 4.1 1.8 0.4 0.8 1.3 -2.0 -0.8
Diabetes (father) 0.2 0.2 0.5 0.2 -0.7 -0.6 -0.1 -0.2 -0.6
Diabetes (mother) 0.8 1.0 3.3 -0.3 1.2 -0.8 -0.2 0.6 -1.8
Severe depression (siblings) 0.3 0.3 0.7 -0.1 0.4 -0.2 -0.6 0.6 -0.8
Pack years adult smoking proportion 0.1 0.1 0.4 0.1 -0.3 -0.0 -0.1 0.2 0.6
Impedance of leg (right) 0.1 0.4 1.9 -0.1 0.3 -0.1 -1.4 0.1 0.7
Leg fat-free mass (left) 0.4 2.1 6.4 0.7 0.5 0.5 2.5 -1.2 -2.0
Trunk fat percentage 0.7 2.9 7.3 2.5 -0.1 1.2 2.7 -1.7 0.3
Hand grip strength (right) 0.6 1.6 7.2 0.6 -1.1 -0.4 0.4 -2.7 -0.6
Townsend deprivation index at recruitment 2.3 3.2 9.6 0.1 -0.2 3.1 1.8 -1.0 2.4
Current tobacco smoking 0.6 1.0 3.5 -1.1 -1.9 -0.1 -0.9 -0.7 -0.4
Average weekly fortified wine intake 0.8 0.9 3.6 0.1 -0.1 -1.9 -1.4 0.4 -0.1
Maternal smoking around birth 0.4 0.6 1.5 -0.6 -0.1 -0.7 -0.9 0.5 1.2
Fed-up feelings 0.2 0.4 1.6 0.9 -0.2 -0.2 0.1 0.3 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 2.9 6.4 0.6 -0.8 1.9 1.9 -2.5 -1.6
Relative age voice broke 1.2 1.9 4.3 0.3 -2.1 -2.0 -1.1 -0.3 -1.2
Taking other prescription medications 1.9 2.9 5.8 0.8 2.4 2.1 1.3 -1.7 -1.3
Age when periods started (menarche) 0.3 0.7 2.6 -0.1 -0.2 1.2 0.1 -0.5 1.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.4 0.2 -1.6 -0.3 -0.5 -1.0 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.7 -0.6 0.8 0.1 0.1 -0.2 -1.3
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.0 -0.4 0.3 -0.4 0.5 1.4 -1.3
Qualifications: CSEs or equivalent 0.2 0.3 1.0 1.0 -0.1 -0.0 0.1 -0.3 0.9
Serious illness, injury or assault to yourself 0.7 0.8 1.9 -0.9 0.1 1.1 0.5 -1.4 -1.0
High blood pressure 1.1 3.0 7.1 2.0 1.9 1.2 2.7 0.3 -1.2
Hayfever, allergic rhinitis or eczema 2.1 4.6 7.8 -2.6 -2.4 0.2 -2.2 -1.5 2.8
Multivitamins +/- minerals 1.3 1.7 3.7 -0.1 -1.9 -1.7 -1.5 -0.4 1.1
Stomach or abdominal pain in last month 1.3 1.6 8.6 -0.4 0.3 0.8 0.0 -2.9 0.1
Supplements: Glucosamine 1.9 2.5 7.4 -0.3 -0.8 -2.7 -2.2 0.9 1.0
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.3 0.7 -1.1 -0.3 -1.0 -1.5 0.7
Medication: Atenolol 2.3 2.8 10.6 2.0 3.3 0.7 1.4 0.0 0.1
Medication: Levothyroxine sodium 2.4 4.1 10.2 3.2 1.0 1.9 2.8 -1.2 0.5
Sitting height 0.2 1.4 3.8 0.4 1.3 -0.7 1.1 0.9 -1.9
Chronic bronchitis/emphysema (father) 1.1 1.3 2.8 -1.7 -1.5 -0.9 -1.3 0.2 -0.4
High blood pressure (mother) 0.8 1.2 2.2 0.4 1.5 0.3 1.5 1.1 -1.2
Body mass index (BMI) 0.5 2.1 6.9 1.4 0.1 1.1 2.6 -1.4 -0.7
Impedance of leg (left) 0.2 0.9 3.9 -0.2 -0.1 -0.6 -2.0 0.6 0.7
Leg predicted mass (left) 0.4 2.2 6.9 0.8 0.6 0.6 2.6 -1.2 -1.9
Trunk fat mass 0.8 3.3 9.2 2.4 0.3 1.1 3.0 -1.7 -0.4
Waist circumference 0.6 2.1 6.2 0.8 1.1 0.4 2.5 -0.3 -2.0
Number of incorrect matches in round 0.0 0.0 0.1 0.1 0.1 -0.3 0.1 -0.2 0.1
Past tobacco smoking 0.9 1.6 3.8 -1.5 0.4 -2.0 -1.7 0.9 0.0
Alcohol usually taken with meals 2.1 3.4 6.7 -2.1 -1.1 -2.5 -2.6 0.7 -0.9
Nervous feelings 0.3 0.6 2.2 1.5 -0.4 -0.7 -0.6 -0.0 -0.7
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 8.0 2.5 -1.9 1.5 1.1 -2.8 -1.4
Hearing difficulty/problems with background noise 0.1 0.2 0.3 -0.1 0.6 0.5 0.5 -0.5 0.5
Hair/balding pattern: Pattern 2 0.9 1.1 3.5 0.7 -0.2 1.5 1.9 -0.2 0.2
Had menopause 1.0 1.3 3.8 -1.9 -0.3 -1.1 -0.9 -0.3 -1.3
Had other major operations 2.2 2.7 6.0 2.5 1.1 1.0 1.6 -2.0 -1.2
Forced vital capacity (FVC) 0.3 1.3 2.7 -0.6 -0.5 1.6 1.5 -1.4 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.3 3.3 -1.8 0.1 -1.3 -0.7 0.1 -1.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 3.6 1.9 0.4 -0.6 -0.3 0.0 -0.4
Qualifications: None of the above 0.6 1.3 3.8 0.3 1.9 1.1 1.6 0.1 -0.2
Financial difficulties in last 2 years 2.5 3.4 5.4 0.9 1.1 2.2 2.3 -2.0 -2.0
Mouth/teeth dental problems 1.6 2.4 11.0 0.9 -0.1 1.6 3.3 -0.3 0.1
Heart attack 2.5 3.1 12.5 0.9 1.0 3.5 1.7 -1.1 0.5
Allergy 1.7 4.0 8.0 2.8 1.6 -0.2 2.1 2.8 -1.3
Pain all over the body in last month 3.2 3.4 5.9 2.4 0.6 1.9 2.4 -1.9 -1.1
Diabetes (self-reported) 1.0 1.6 4.4 0.6 -0.1 1.4 1.7 -2.1 -0.3
Hayfever/allergic rhinitis (self-reported) 2.7 3.6 9.5 -1.4 -1.1 -0.1 -2.4 -1.7 3.1
Medication: Ramipril 0.2 0.3 0.9 1.0 0.4 -0.3 0.4 0.7 0.1
Medication: Simvastatin 0.8 1.2 5.7 1.0 0.2 0.6 0.2 -2.4 -0.2
Fluid intelligence score 1.3 2.7 12.0 -1.0 -1.0 -0.8 -1.1 3.5 0.7
Illnesses of siblings 1.1 1.5 3.6 -1.0 -1.2 -0.2 -1.4 1.9 1.1
Neuroticism score 0.4 0.9 3.1 1.8 -1.0 -0.2 -0.2 0.8 -0.7
Weight 0.6 2.8 9.2 1.3 0.7 0.8 3.0 -1.4 -1.6
Impedance of arm (right) 0.2 0.8 2.1 1.4 -0.3 -0.1 -0.6 -0.3 1.4
Arm fat percentage (right) 0.7 2.6 6.0 2.4 -0.3 0.9 2.4 -1.7 0.1
Trunk fat-free mass 0.3 2.0 7.6 -0.2 1.1 -0.3 1.7 -0.3 -2.8
Hip circumference 0.7 3.1 10.6 1.4 -0.3 1.4 3.3 -1.8 -0.5
Time employed in main current job 0.8 1.0 2.7 0.7 -0.1 0.3 0.7 -1.6 -1.4
Alcohol intake versus 10 years previously 1.7 2.5 4.5 -0.3 1.4 2.0 2.1 -1.8 -1.3
Father’s age at death 0.5 0.7 1.3 -1.1 -0.7 -0.3 -1.2 1.0 -0.3
Worrier / anxious feelings 0.7 1.3 2.8 0.0 -0.7 -1.6 -1.2 1.7 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 4.1 2.0 -0.3 1.4 1.9 -1.9 -1.4
Falls in the last year 0.2 0.3 0.6 -0.3 -0.8 0.4 -0.1 -0.8 -0.6
Hair/balding pattern: Pattern 3 0.3 0.4 0.6 -0.5 -0.8 0.7 -0.5 -0.7 -0.3
Number of live births 0.1 0.1 0.3 -0.5 0.4 -0.3 0.1 0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.3 0.8 2.4 0.4 -0.6 0.8 0.9 -1.5 -0.8
Pulse rate 0.5 0.8 2.1 1.4 -0.4 1.1 0.0 -1.3 0.1
Happiness 0.8 1.0 2.5 1.6 -0.1 1.1 1.5 -0.1 0.0
Noisy workplace 1.0 1.3 3.8 -0.2 -1.2 0.9 1.2 -2.0 0.1
Qualifications: A levels/AS levels or equivalent 0.8 1.7 4.4 -0.1 -0.3 -1.6 -2.1 1.4 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.2 0.5 0.8 -1.4 -0.7 -0.5 -1.5
Mouth/teeth dental problems: Dentures 0.7 1.2 2.2 -1.1 -1.2 0.6 -1.0 -1.5 0.9
Asthma 1.6 3.2 10.1 -2.2 1.7 1.0 -0.1 -3.2 -0.1
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 2.7 1.7 1.2 1.4 1.6 -1.1 0.7
Medication: Cholesterol lowering 0.5 0.8 1.8 0.9 1.4 0.7 0.4 -1.0 -0.5
Depression (self-reported) 0.2 0.3 0.6 0.6 -0.5 -0.5 -0.2 -0.8 -0.5
Medication: Lansoprazole 0.1 0.1 0.2 -0.2 0.1 -0.1 -0.3 0.5 -0.0
Prospective memory result 1.8 2.2 3.8 0.5 1.9 1.4 1.3 -1.9 -1.4
Lung cancer (father) 0.7 0.8 2.3 -1.2 -1.5 0.3 -0.3 1.0 0.6
Illnesses of mother 0.7 0.9 2.6 0.4 -0.5 1.5 0.3 0.5 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 1.7 0.6 -1.3 1.0 1.1 -1.2 -0.9
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 1.0 -0.1 0.8 0.7 -1.2 -0.7
Impedance of arm (left) 0.2 1.0 3.2 1.3 -0.7 0.2 -0.5 -0.5 1.8
Arm fat mass (right) 0.6 2.6 8.0 1.9 0.1 1.1 2.8 -1.6 -0.6
Trunk predicted mass 0.3 1.9 7.4 -0.2 1.0 -0.3 1.7 -0.4 -2.7
Standing height 0.1 1.2 4.2 0.1 1.3 -0.4 1.1 0.2 -2.1
Length of working week for main job 0.1 0.1 0.3 0.4 -0.3 -0.6 0.1 0.2 -0.3
Exposure to tobacco smoke at home 1.7 2.0 5.6 1.3 0.9 1.4 2.4 -1.1 -0.7
Breastfed as a baby 1.2 1.4 4.7 1.1 0.9 -0.9 1.0 -0.4 -2.2
Tense / ‘highly strung’ 1.3 2.2 5.9 2.4 0.7 1.4 1.8 -0.1 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.5 0.7 0.0 0.3 -0.2 0.4 0.0
Hair/balding pattern: Pattern 4 0.2 0.6 1.3 0.0 -0.3 0.8 -0.2 1.1 1.2
Birth weight of first child 1.6 2.9 6.3 0.7 -1.9 -2.5 -2.0 1.2 -1.2
Peak expiratory flow (PEF) 0.1 0.2 0.8 -0.4 -0.1 -0.2 -0.9 -0.3 -0.6
Pulse wave reflection index 0.5 0.6 2.4 0.8 0.2 -0.5 0.5 0.0 -1.6
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.7 0.2 -0.2 -0.3 0.0 -0.1 -0.8
Loud music exposure frequency 0.4 0.4 1.4 -0.7 -1.2 0.5 0.5 0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.9 1.7 0.1 -0.4 1.1 1.1 -1.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 5.3 0.2 2.3 -0.1 -0.9 0.8 -0.3
Blood clot in the leg (DVT) 0.6 0.7 1.7 -0.5 -0.8 0.9 0.5 -1.0 -1.3
Medication: Paracetamol 1.9 3.1 6.8 1.3 -0.1 2.0 2.6 -2.5 -0.4
Headache pain in last month 2.0 3.4 8.4 2.2 1.2 1.3 1.8 -2.9 0.6
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 4.8 -2.1 -1.1 -2.2 -1.9 1.2 0.0
Glaucoma (self-reported) 1.2 1.4 3.1 1.5 -0.4 1.6 0.6 -1.8 -0.1
Gout (self-reported) 0.9 1.2 4.1 -0.2 0.6 1.0 -0.4 -1.2 2.0
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 7.7 2.8 0.7 1.2 2.1 0.5 0.2
Medication: Amlodipine 1.2 1.7 4.1 2.0 1.5 1.3 1.3 0.1 -0.3
Medication: Ventolin 100micrograms inhaler 1.8 2.3 6.3 -0.7 -0.1 0.2 -0.6 -2.5 2.5
Birth weight 1.3 2.9 7.3 2.7 1.4 1.1 2.0 -1.5 -0.8
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.6 0.4 0.6 1.0 0.0 -1.3 0.8
High blood pressure (siblings) 1.1 1.6 3.1 1.4 0.7 0.7 1.8 -1.8 -0.8
Forced vital capacity (FVC), Best measure 0.4 1.3 2.6 -0.1 -0.7 1.5 1.6 -1.1 -1.2
Body fat percentage 0.7 2.8 6.6 2.5 0.1 1.1 2.6 -1.8 0.2
Leg fat percentage (right) 0.5 1.8 4.0 2.0 0.6 0.8 2.0 -1.4 -0.4
Arm fat-free mass (right) 0.4 2.0 6.6 -0.0 0.9 0.2 2.0 -0.9 -2.6
Exposure to tobacco smoke outside home 1.5 2.0 4.0 1.3 0.1 2.0 2.0 1.3 -0.8
Comparative body size at age 10 0.8 2.3 6.0 0.8 -0.2 2.3 2.4 -1.2 -0.4
Number of full brothers 0.2 0.3 0.6 0.2 -0.6 0.8 -0.2 -0.5 0.6
Worry too long after embarrassment 0.7 1.1 3.1 0.9 -0.5 -1.3 -0.7 1.8 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 4.0 0.4 0.5 -1.1 -0.8 1.3 -2.0
Wheeze or whistling in the chest in last year 0.9 1.6 4.9 -0.6 0.2 2.2 0.9 -1.8 0.6
Number of children fathered 2.0 2.3 6.8 1.0 1.5 1.8 2.6 -0.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 3.3 1.7 -1.1 1.8 1.7 -0.3 1.1
Age at first live birth 2.7 4.9 8.8 -2.1 -1.6 -2.8 -3.0 2.3 0.1
Pulse wave peak to peak time 0.5 0.6 1.5 -0.9 0.3 -0.6 -0.5 1.2 0.6
Health satisfaction 2.1 2.7 6.1 1.6 1.1 1.5 2.5 -1.8 -0.9
Shortness of breath walking on level ground 0.7 0.8 1.8 -0.1 -0.4 1.4 1.2 -1.1 -0.6
Qualifications: College or University degree 0.9 3.0 7.9 -1.4 0.1 -1.8 -2.8 0.8 2.0
Eye problems/disorders: None of the above 0.5 0.6 1.4 -1.2 -0.9 -0.3 -0.2 1.0 -0.2
Mouth/teeth dental problems: Loose teeth 0.8 0.9 3.4 -0.6 -0.9 0.3 -0.7 -1.8 0.8
Emphysema/chronic bronchitis 0.6 0.7 3.0 -0.1 -0.9 0.5 -0.1 -1.7 -0.2
Medication for pain relief, constipation, heartburn 1.9 3.2 8.8 -1.7 -0.9 -1.8 -1.8 3.0 -0.2
Neck or shoulder pain in last month 0.2 0.3 1.2 -0.4 0.3 -1.1 -0.3 -0.3 -0.4
Medication: Blood pressure 3.3 5.8 10.2 2.2 3.2 3.0 3.2 -0.4 0.3
Angina (self-reported) 1.1 1.5 5.1 -0.4 2.3 1.7 0.9 0.4 0.1
Migraine (self-reported) 1.2 1.5 2.8 1.6 1.7 0.6 1.5 -0.2 -0.9
Medication: Ibuprofen 1.5 1.8 3.2 1.8 1.1 1.3 1.8 -1.0 -0.2
Medication: Allopurinol 0.3 0.5 1.8 -0.5 0.4 1.4 0.5 -0.2 0.4
Medication: Omeprazole 0.5 0.7 1.9 0.7 1.4 -0.1 0.1 -0.6 -1.1
Medication: Seretide 50 evohaler 2.4 2.7 9.3 -0.2 1.2 3.0 2.2 -0.8 0.3
Mean time to correctly identify matches 1.8 3.5 6.7 -1.4 0.4 -2.6 -2.6 1.8 -1.5
Heart disease (mother) 0.4 0.5 0.9 -0.0 0.7 -1.0 -0.2 -0.9 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.9 0.0 0.3 1.7 1.3 -1.4 -0.2
Whole body fat mass 0.7 2.7 7.8 2.1 0.4 0.9 2.8 -1.6 -0.7
Leg fat mass (right) 0.6 2.5 6.4 1.8 0.6 0.9 2.5 -1.6 -1.2
Arm predicted mass (right) 0.4 2.1 7.3 0.1 0.7 0.0 1.9 -1.0 -2.7
Pulse rate, automated reading 0.3 1.0 2.2 0.9 0.2 1.5 0.4 -1.5 -0.5
Alcohol intake frequency. 0.6 1.4 5.2 -2.3 -0.5 0.2 0.4 -1.5 -0.3
Comparative height size at age 10 0.3 1.9 3.8 -0.3 1.8 0.6 1.9 -0.9 -1.8
Number of full sisters 3.0 3.7 7.5 2.1 1.4 1.8 2.7 -2.2 0.4
Suffer from ‘nerves’ 0.5 0.9 2.7 0.4 -1.1 0.5 0.9 0.1 -1.6
Overall health rating 4.5 9.7 19.1 2.8 2.3 4.1 4.4 -3.0 -0.7
Chest pain or discomfort 0.9 1.3 2.6 0.3 1.6 1.6 1.3 -0.9 -0.3
Had major operations 0.9 1.1 1.8 1.3 -1.0 1.0 0.9 -0.6 1.3
Age at last live birth 1.8 2.6 4.6 -1.1 -1.1 -2.0 -2.2 2.1 -0.5
Family relationship satisfaction 1.9 2.4 5.5 2.0 1.1 1.4 2.4 0.7 -1.1
Leg pain on walking 0.3 0.4 1.7 0.3 0.2 0.7 0.3 -0.0 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 5.7 -2.4 -0.3 -0.7 -0.0 0.5 0.0
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.2 0.1 -0.1 -1.1 -0.7 -0.8 -0.6
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.1 -0.6 -1.6 -0.3 -0.5 1.8 1.3
Medication: Aspirin 1.0 1.3 2.0 -0.4 1.3 1.4 0.5 -1.4 1.3
Supplements: Vitamin C 1.4 1.6 3.6 1.2 1.9 1.0 1.8 -0.0 -0.7
Knee pain experienced in last month 0.3 0.5 1.7 0.7 1.3 -0.2 0.1 -0.4 -0.8
Hypertension (Self-reported) 1.1 3.0 6.9 1.8 2.1 1.3 2.6 0.4 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 6.9 0.7 2.6 0.2 0.9 -0.9 -1.2
Illnesses of father: Heart disease 0.5 0.7 1.3 -0.6 1.2 -0.8 -0.9 -0.8 -0.3
Illnesses of siblings: Diabetes 1.4 1.8 4.5 1.0 0.0 0.6 1.8 -2.1 -1.2
Smoking status: Previous 0.8 1.2 2.5 1.6 -0.0 1.6 1.2 -0.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.6 3.3 0.7 0.9 1.0 1.8 -0.8 -1.8
Whole body fat-free mass 0.3 1.8 5.5 0.1 0.8 0.1 2.1 -0.7 -2.4
Leg fat-free mass (right) 0.3 1.6 5.0 0.5 0.3 0.2 2.2 -0.9 -1.9
Arm fat percentage (left) 0.7 2.7 5.9 2.3 -0.6 1.1 2.4 -1.9 0.2
Average weekly red wine intake 0.4 0.7 1.6 -1.3 -1.1 -0.0 -0.8 -0.3 0.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 -0.9 -0.7 -0.5 -0.1 0.7 1.1
Mood swings 0.4 0.7 1.8 1.2 -0.3 -0.3 -0.4 -1.3 -0.7
Loneliness, isolation 1.9 2.7 4.7 1.5 -0.1 2.1 2.2 -1.4 -1.5
Long-standing illness, disability or infirmity 4.7 7.2 13.1 1.9 2.3 3.6 3.2 -3.1 -1.2
Ever had bowel cancer screening 0.9 1.0 3.3 1.8 0.9 1.1 0.7 -0.2 -0.6
Diabetes diagnosed by doctor 0.7 1.2 2.3 1.5 0.2 0.7 1.5 -1.5 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.1 -1.0 1.3 0.6 0.4 -1.4 0.1
Friendships satisfaction 1.9 2.4 4.8 0.3 1.5 1.5 2.2 1.1 -1.9
Qualifications: nursing, teaching 0.9 1.4 2.6 1.2 -0.4 -1.6 -1.5 0.0 -1.4
Commuting to job workplace: Walk 1.0 1.1 2.8 -0.0 -1.7 -1.2 -1.2 0.1 0.9
Eye problems/disorders: Cataract 0.8 0.9 3.4 1.9 0.6 -0.4 -0.7 -0.9 0.3
Mouth/teeth dental problems: Mouth ulcers 4.5 7.1 19.3 -1.7 -1.3 -2.8 -4.4 2.2 2.4
Medication for cholesterol 0.5 0.7 2.1 -0.5 -1.5 -0.1 -0.1 1.1 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 3.1 -0.4 -0.0 -0.4 -0.9 -1.8 1.6
Back pain experienced in last month 0.9 1.3 3.3 -1.8 -1.1 0.4 0.1 -1.6 -0.9
Mineral and other dietary supplements 1.4 1.9 5.1 0.6 0.8 2.2 1.9 -1.0 -0.9
Breast cancer (self-reported) 2.0 2.4 6.8 -1.7 -0.9 -1.4 -1.2 2.6 -0.7
Asthma (self-reported) 1.6 3.2 10.1 -2.2 1.7 1.2 0.1 -3.2 0.1
Osteoporosis (self-reported) 0.9 1.1 3.7 1.9 0.1 0.2 1.0 0.8 0.9
Osteoarthritis (self-reported) 3.1 4.0 8.1 2.8 1.0 2.2 2.4 -2.0 0.6
Medication: Aspirin 0.7 0.9 1.7 -0.8 1.3 0.8 -0.3 -0.8 1.3
Medication: Gliclazide 0.7 0.7 2.8 0.5 0.4 0.9 1.7 0.5 -0.5
Illnesses of father: None of the above (group 1) 1.0 1.3 4.6 0.2 -2.2 -0.7 -0.3 1.4 0.7
Smoking status: Current 0.6 1.0 3.9 -1.0 -2.0 -0.1 -0.7 -0.8 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.8 -0.1 0.1 0.9 0.8 -0.4 0.7
Whole body water mass 0.4 2.0 5.5 0.2 0.8 0.2 2.3 -0.8 -2.4
Leg predicted mass (right) 0.3 1.7 5.2 0.5 0.3 0.3 2.3 -0.9 -2.0
Arm fat mass (left) 0.7 2.8 8.2 2.0 -0.2 1.0 2.9 -1.8 -0.5
Number of self-reported non-cancer illnesses 1.5 2.7 5.5 1.3 2.3 2.2 1.6 -0.8 -0.9
Average weekly champagne plus white wine intake 1.3 1.8 4.3 0.7 -0.5 -2.1 -1.5 1.7 0.8
Miserableness 0.6 1.0 3.5 1.2 -1.9 -0.1 -0.8 0.1 0.5
Guilty feelings 0.9 1.3 4.9 1.1 -2.2 -0.8 -1.1 0.0 -0.0
Wears glasses or contact lenses 1.3 1.5 2.6 0.5 1.5 -1.6 -1.1 1.6 0.2
Ever taken oral contraceptive pill 1.4 1.6 6.2 1.1 -2.5 -1.1 -0.7 -0.7 0.1
Hearing aid user 1.3 1.5 3.7 0.0 -1.9 -1.3 -1.5 0.9 0.8
Mother’s age at death 0.7 0.8 2.2 -0.2 -1.2 -1.5 -1.0 0.4 0.5
Financial situation satisfaction 2.5 3.0 8.5 0.8 0.4 2.0 2.9 -1.9 -1.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.7 0.7 0.2 0.8 1.6 -0.9 0.8
Commuting to job workplace: Public transport 0.4 0.5 1.1 0.6 -1.0 0.6 -0.6 -0.2 1.0
Eye problems/disorders: Glaucoma 0.9 1.0 3.4 0.8 -1.9 0.5 -0.5 -1.2 0.5
Medication: Blood pressure 0.5 1.0 2.5 0.9 1.0 -1.2 0.0 -0.4 -1.6
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.7 -0.9 -1.6 -1.3 -1.9 -0.3 -0.2
Supplements: Fish oil (including cod liver oil) 1.5 2.0 4.0 -1.2 -1.3 -2.0 -1.7 0.1 1.3
High cholesterol (Self-reported) 0.4 0.7 1.5 0.8 0.7 -0.6 0.0 -1.0 -1.2
Medication: Bendroflumethiazide 0.2 0.2 0.4 0.3 0.3 -0.4 0.6 -0.6 -0.6
Medication: Paracetamol 1.0 1.5 3.4 1.1 -0.3 1.5 1.9 -1.4 -0.2
Medication: Lisinopril 0.4 0.5 1.4 -0.1 -1.2 -0.4 -1.0 -0.7 -0.1
Medication: Atorvastatin 0.5 0.6 1.7 -0.5 0.7 1.3 0.5 -0.3 -0.9
Illnesses of father: High blood pressure 1.8 2.2 4.8 1.0 1.0 2.1 2.2 -1.4 -0.3
Alcohol drinker status: Never 0.4 0.5 1.3 -1.2 1.1 0.1 0.6 -0.1 -0.5
Ever smoked 0.4 0.8 2.2 0.5 -1.5 1.1 0.6 -0.8 -0.1
Basal metabolic rate 0.4 2.1 6.3 0.4 0.8 0.4 2.5 -0.9 -2.1
Leg fat percentage (left) 0.4 1.4 3.7 1.9 0.4 0.5 1.7 -1.1 -0.3
Arm fat-free mass (left) 0.4 2.2 6.2 0.3 0.9 0.0 2.3 -0.6 -2.5
Number of operations (self-reported) 0.7 1.0 3.3 1.8 -0.3 1.0 0.9 -1.0 0.1
Average weekly beer plus cider intake 0.8 1.2 4.5 2.1 0.1 0.4 1.3 0.3 0.9
Irritability 0.9 1.5 4.6 2.1 0.9 1.1 1.3 -0.4 -0.7
Risk taking 0.1 0.1 0.5 -0.2 0.7 0.1 0.2 0.1 -0.5
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 -0.5 -0.4 0.5 -0.5 1.1 1.2
Fractured/broken bones in last 5 years 1.0 1.3 3.8 0.1 1.2 1.0 1.3 -1.9 -0.0
Age started oral contraceptive pill 0.7 0.9 2.0 -0.7 1.1 -1.4 -0.9 0.7 -0.4
Diastolic blood pressure, automated reading 0.8 2.5 8.6 1.4 2.9 0.5 2.0 0.4 0.0
Ever depressed for a whole week 0.8 0.9 2.4 1.6 0.2 -1.4 -0.1 -0.1 -1.1
Unable to work because of sickness or disability 2.5 3.3 7.0 -0.0 0.3 2.6 2.4 -1.8 -2.0
Commuting to job workplace: Cycle 0.3 0.4 1.6 -0.3 -0.2 -0.1 0.6 1.3 0.1
Myopia 0.3 0.4 1.4 -0.4 -1.2 0.1 0.5 1.0 -0.1
Vascular/heart problems diagnosed by doctor 0.8 2.3 5.1 -1.6 -1.7 -1.4 -2.2 -0.1 1.1
Cholesterol lowering medication 0.6 0.9 3.6 -0.3 1.1 0.3 0.3 -1.9 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.1 1.3 1.1 0.4 0.7 -1.5 -1.4
Pain experienced in last month 1.3 2.1 4.0 -1.5 -0.6 -0.7 -1.4 2.0 1.9
Supplements: Calcium 0.6 0.7 2.7 -1.6 -0.7 0.6 0.1 0.5 0.6
Basal cell carcinoma (self-reported) 0.9 1.1 2.4 0.1 0.3 1.5 1.0 -1.4 -1.0
Heart attack/myocardial infarction (self-reported) 2.0 2.6 10.0 1.0 1.1 3.2 1.6 -0.8 0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.3 -0.5 -1.1 0.9 0.4 -0.9 -1.0
Heart disease (siblings) 0.5 0.6 2.0 1.1 1.4 0.3 0.2 -0.5 0.3
Alcohol drinker status: Previous 0.7 0.8 1.9 -1.3 -1.4 -0.9 -0.5 0.4 -0.5
Pack years of smoking 0.1 0.1 0.7 -0.0 -0.1 0.0 0.1 0.2 0.8
Impedance of whole body 0.2 0.8 2.2 0.9 -0.8 -0.1 -1.1 -0.1 1.5
Leg fat mass (left) 0.5 2.1 5.3 1.8 0.5 0.7 2.3 -1.5 -1.0
Arm predicted mass (left) 0.4 2.2 6.1 0.1 1.1 0.1 2.3 -0.7 -2.5