Hub : Genes

TOMM40L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0464	0.0208	3.7e-03	0.002	0.013	0.005	0.013	0.003	1.2e-01	4.3e-03	4.7e-02	4.2e-03	1.2e-01
2	YFS	Blood	0.2169	0.0384	2.0e-15	0.020	0.064	0.073	0.065	0.046	3.0e-07	4.6e-20	7.0e-23	2.6e-20	5.8e-15
3	TCGA	Glioblastoma Multiforme	0.1550	0.0800	7.5e-03	0.083	-0.005	-0.010	NA	0.005	1.7e-03	5.0e-01	9.0e-01	NA	2.2e-01
4	TCGA	Brain Lower Grade Glioma	0.0422	0.0225	1.1e-03	0.010	0.024	0.010	NA	0.011	2.4e-02	7.7e-04	2.0e-02	NA	1.7e-02
5	TCGA	Pheochromocytoma and Paraganglioma	0.1640	0.0760	6.7e-03	0.065	0.008	0.041	NA	0.047	1.4e-03	1.5e-01	9.8e-03	NA	6.0e-03
6	TCGA	Testicular Germ Cell Tumors	0.1630	0.0690	2.2e-03	0.026	0.021	0.016	NA	0.022	4.2e-02	6.1e-02	8.9e-02	NA	5.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.7	4.3	11.6	0.6	-0.9	-3.4	-3.0	1.4	-1.4
Bipolar Disorder or Schizophrenia	1.8	4.4	10.3	1.2	-1.0	-3.2	-2.6	1.6	-2.1
Depressed Affect (Nagel 2018)	0.2	0.4	1.6	1.2	-0.4	-0.1	-0.1	-0.2	-0.6
Depression (Nagel 2018)	1.6	2.5	4.4	1.2	-1.1	2.1	2.1	-1.4	-1.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.0	-0.1	-0.4	-0.2	-0.7	1.4	1.1
Neuroticism (Nagel 2018)	0.3	0.6	1.0	0.9	-1.0	-0.7	-0.8	0.5	-0.9
Schizophrenia (2018)	0.6	1.2	2.3	1.0	-0.6	-1.4	-0.9	0.9	-1.5
Schizophrenia vs Biploar Disorder	1.2	1.6	3.4	0.5	-0.5	1.7	1.2	-1.9	1.0
Worry (Nagel 2018)	0.5	1.0	2.4	-0.3	-1.1	-0.6	-0.4	1.3	-1.5
Alzheimer’s Disease (in mother)	1.3	1.5	4.8	-0.7	-0.4	-2.2	-1.2	0.8	-1.2
Alzheimer’s Disease (in father)	1.2	1.3	2.6	-0.6	-1.5	-0.7	-1.5	1.6	-0.2
Alzheimer’s Disease (including proxy)	1.9	2.8	5.9	-0.8	-0.8	-2.4	-1.5	1.9	-1.8
Crohns Disease (2017)	2.2	4.8	14.1	3.0	0.4	-1.6	-1.9	-3.8	0.3
Irritable Bowel Disease (IBD)	2.3	5.5	19.5	2.0	0.7	-1.9	-2.1	-4.4	-0.7
Ulcerative Colitis (UC)	1.6	3.1	10.4	0.1	1.0	-1.5	-1.5	-3.2	-1.6
Major Depression (MDD)	1.4	1.7	4.2	0.7	-0.2	2.1	1.7	-1.3	-0.9
Reaction Time	1.3	2.4	3.8	-1.4	-0.8	-1.9	-1.9	1.5	-1.4
Verbal and Numeric Reasoning (VNR)	1.2	3.0	5.8	-1.7	-1.3	-2.0	-1.7	2.4	-0.6
Breast Cancer	0.2	0.4	1.5	1.2	-0.3	-0.1	0.4	0.8	0.1
Ovarian Cancer	1.0	1.3	4.2	2.0	0.2	-0.9	-0.7	-1.2	0.8
Prostate Cancer	0.6	0.8	3.0	-0.1	-0.8	1.7	1.0	0.4	0.2
Age at First Birth	0.8	1.1	2.0	-0.0	-0.9	-1.3	-1.4	1.1	0.9
Bipolar Disorder (2011)	2.8	2.8	8.7	1.1	-0.8	-3.0	-1.8	1.4	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.6	-0.6	0.6	0.8	-0.6	-0.4
Coronary Artery Disease (CAD)	2.2	2.6	5.3	-1.5	0.0	-2.2	-1.4	2.3	-1.1
Crohns Disease (2012)	1.8	2.9	9.0	2.5	0.6	-0.9	-0.8	-3.0	0.1
Mean Putamen Volume	0.5	0.5	2.3	0.3	0.0	-0.0	-0.0	-0.9	1.5
Fasting Glucose	0.8	1.0	2.3	-1.5	-0.2	-0.9	-0.9	0.8	-1.2
HbA1C	0.7	0.8	3.3	-0.2	0.3	-1.1	-1.8	-0.2	0.4
HDL Cholesterol	1.5	2.6	7.2	-2.7	0.0	-0.6	-1.0	2.1	1.6
LDL Cholesterol	0.8	1.2	4.5	-2.1	-1.0	-0.2	-0.3	-1.1	-0.6
Lupus	1.3	2.0	8.2	2.9	-0.0	-0.6	0.7	1.3	-1.1
Neuroticism (2016)	0.5	0.7	1.9	1.4	-0.9	-0.5	-0.9	-0.8	0.0
Primary Biliary Cirrhosis	0.8	1.2	3.1	-0.5	1.0	1.8	1.6	0.2	0.2
Rheumatoid Arthritis	0.9	1.3	4.2	-1.4	-0.5	0.8	-0.4	-2.0	0.6
Schizophrenia (2014)	0.9	2.1	4.6	1.1	-0.0	-2.1	-1.1	1.7	-1.6
Triglycerides	1.1	1.8	8.5	0.2	-0.5	0.5	0.7	-2.9	-1.0
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	-1.4	-0.1	-1.5	-0.9	-0.3	-1.0
Ulcerative Colitis	1.5	2.1	6.7	1.6	0.8	-0.8	-0.6	-2.6	-1.4
Blood Eosinophil Count	1.2	9.0	23.7	-1.7	-3.2	2.9	-0.7	-4.9	2.8
Blood Platelet Count	0.6	6.9	18.7	-0.4	2.0	-4.3	-1.6	3.4	-2.0
Blood Red Count	0.7	6.5	19.4	-2.8	0.5	2.8	2.0	-4.4	0.3
Blood White Count	2.1	15.3	37.9	3.9	-0.8	4.8	2.9	-6.2	2.7
Heel T-Score	0.1	0.8	2.1	-1.3	-0.4	-0.4	-0.6	-0.5	-1.4
BMI	0.7	4.1	14.3	1.3	-0.0	2.1	3.8	-1.7	-1.1
Height	0.0	0.8	2.9	-0.3	1.0	-0.0	1.0	-0.4	-1.7
Waist Hip Ratio (WHR)	1.1	4.8	6.4	-1.6	1.6	-2.5	-2.4	2.2	-2.5
Systolic Blood Pressure	1.1	5.5	11.2	2.1	2.5	3.2	3.3	0.3	1.1
Smoking Status	0.3	0.7	2.9	0.8	-1.7	0.6	-0.0	-0.2	0.2
Allergy or Eczema	2.9	7.6	13.2	-3.4	-2.7	-0.4	-3.4	-1.3	3.6
Cardiovascular Disease	0.3	1.1	3.5	0.3	0.7	1.1	1.9	0.4	-1.2
Hypothyroidism (self reported)	0.4	0.9	3.1	1.8	0.2	0.4	1.3	0.7	0.3
Respiratory disease	1.3	2.9	8.5	-1.7	1.3	1.4	-0.0	-2.9	1.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.0	1.1	0.3	0.2	1.4	-1.1	-0.7
Lung FEV1/FVC ratio	0.8	4.1	10.2	1.9	-2.0	-3.2	-2.5	-0.7	0.3
Lung FVC	0.1	0.6	2.5	-1.6	-0.4	-0.1	-0.6	0.7	-0.5
Neuroticism	0.3	0.7	1.7	1.2	-0.6	-0.7	-0.6	-0.3	-1.3
Chronotype (morning person)	1.3	3.1	6.2	-2.3	-1.6	-2.1	-2.5	-0.0	0.1
Hair Pigment	0.0	0.5	1.2	1.1	1.1	-0.7	0.2	-0.1	-0.6
Tanning	0.1	1.7	3.4	-1.0	-0.7	1.6	1.7	0.3	-1.8
Hand grip strength (left)	0.4	1.1	6.2	0.4	-0.4	0.3	0.4	-2.5	0.5
Number of treatments/medications taken	1.1	2.0	5.1	2.1	2.3	1.1	0.6	-0.8	-0.4
Average weekly spirits intake	0.2	0.2	0.7	0.0	-0.6	-0.2	-0.9	0.1	0.2
Sensitivity / hurt feelings	0.5	0.9	2.0	1.3	-0.4	-0.3	0.2	1.2	-1.4
Frequency of depressed mood in last 2 weeks	2.5	3.6	9.7	1.9	-1.1	2.0	1.5	-3.1	-0.7
Hearing difficulty/problems: Yes	1.1	1.7	4.4	0.9	0.4	2.0	2.1	-0.6	0.9
Relative age of first facial hair	0.4	0.9	2.2	0.6	-1.5	-1.2	-1.0	0.3	0.3
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	5.0	1.4	1.4	2.2	2.1	-1.3	-1.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.6	1.1	-0.5	-0.4	0.6	-0.9	-1.3
Ever had hysterectomy (womb removed)	0.4	0.5	1.4	0.5	-0.4	-0.9	-0.4	-0.5	-1.2
Systolic blood pressure, automated reading	1.3	3.9	7.9	2.7	2.8	1.3	2.3	-0.6	1.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.6	0.6	-0.5	0.9	1.6	-1.9	-0.0
Angina	1.1	1.4	5.1	-0.7	2.3	1.6	0.6	0.3	0.2
Medication for hormone replacement therapy	0.5	0.5	1.8	0.4	-0.2	-0.1	-1.0	-1.4	0.0
Vitamin and mineral supplements	0.5	0.6	1.1	-0.4	1.1	1.0	0.9	0.5	-0.5
Supplements: Zinc	0.5	0.5	2.3	-0.2	-0.7	-1.5	-0.3	-0.1	0.6
Medication: Co-codamol	2.5	2.9	9.4	1.4	-0.5	1.6	1.7	-3.1	-0.6
Medication: Metformin	1.3	1.8	4.1	1.8	0.4	0.8	1.3	-2.0	-0.8
Diabetes (father)	0.2	0.2	0.5	0.2	-0.7	-0.6	-0.1	-0.2	-0.6
Diabetes (mother)	0.8	1.0	3.3	-0.3	1.2	-0.8	-0.2	0.6	-1.8
Severe depression (siblings)	0.3	0.3	0.7	-0.1	0.4	-0.2	-0.6	0.6	-0.8
Pack years adult smoking proportion	0.1	0.1	0.4	0.1	-0.3	-0.0	-0.1	0.2	0.6
Impedance of leg (right)	0.1	0.4	1.9	-0.1	0.3	-0.1	-1.4	0.1	0.7
Leg fat-free mass (left)	0.4	2.1	6.4	0.7	0.5	0.5	2.5	-1.2	-2.0
Trunk fat percentage	0.7	2.9	7.3	2.5	-0.1	1.2	2.7	-1.7	0.3
Hand grip strength (right)	0.6	1.6	7.2	0.6	-1.1	-0.4	0.4	-2.7	-0.6
Townsend deprivation index at recruitment	2.3	3.2	9.6	0.1	-0.2	3.1	1.8	-1.0	2.4
Current tobacco smoking	0.6	1.0	3.5	-1.1	-1.9	-0.1	-0.9	-0.7	-0.4
Average weekly fortified wine intake	0.8	0.9	3.6	0.1	-0.1	-1.9	-1.4	0.4	-0.1
Maternal smoking around birth	0.4	0.6	1.5	-0.6	-0.1	-0.7	-0.9	0.5	1.2
Fed-up feelings	0.2	0.4	1.6	0.9	-0.2	-0.2	0.1	0.3	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	6.4	0.6	-0.8	1.9	1.9	-2.5	-1.6
Relative age voice broke	1.2	1.9	4.3	0.3	-2.1	-2.0	-1.1	-0.3	-1.2
Taking other prescription medications	1.9	2.9	5.8	0.8	2.4	2.1	1.3	-1.7	-1.3
Age when periods started (menarche)	0.3	0.7	2.6	-0.1	-0.2	1.2	0.1	-0.5	1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.4	0.2	-1.6	-0.3	-0.5	-1.0	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	-0.6	0.8	0.1	0.1	-0.2	-1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	-0.4	0.3	-0.4	0.5	1.4	-1.3
Qualifications: CSEs or equivalent	0.2	0.3	1.0	1.0	-0.1	-0.0	0.1	-0.3	0.9
Serious illness, injury or assault to yourself	0.7	0.8	1.9	-0.9	0.1	1.1	0.5	-1.4	-1.0
High blood pressure	1.1	3.0	7.1	2.0	1.9	1.2	2.7	0.3	-1.2
Hayfever, allergic rhinitis or eczema	2.1	4.6	7.8	-2.6	-2.4	0.2	-2.2	-1.5	2.8
Multivitamins +/- minerals	1.3	1.7	3.7	-0.1	-1.9	-1.7	-1.5	-0.4	1.1
Stomach or abdominal pain in last month	1.3	1.6	8.6	-0.4	0.3	0.8	0.0	-2.9	0.1
Supplements: Glucosamine	1.9	2.5	7.4	-0.3	-0.8	-2.7	-2.2	0.9	1.0
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.3	0.7	-1.1	-0.3	-1.0	-1.5	0.7
Medication: Atenolol	2.3	2.8	10.6	2.0	3.3	0.7	1.4	0.0	0.1
Medication: Levothyroxine sodium	2.4	4.1	10.2	3.2	1.0	1.9	2.8	-1.2	0.5
Sitting height	0.2	1.4	3.8	0.4	1.3	-0.7	1.1	0.9	-1.9
Chronic bronchitis/emphysema (father)	1.1	1.3	2.8	-1.7	-1.5	-0.9	-1.3	0.2	-0.4
High blood pressure (mother)	0.8	1.2	2.2	0.4	1.5	0.3	1.5	1.1	-1.2
Body mass index (BMI)	0.5	2.1	6.9	1.4	0.1	1.1	2.6	-1.4	-0.7
Impedance of leg (left)	0.2	0.9	3.9	-0.2	-0.1	-0.6	-2.0	0.6	0.7
Leg predicted mass (left)	0.4	2.2	6.9	0.8	0.6	0.6	2.6	-1.2	-1.9
Trunk fat mass	0.8	3.3	9.2	2.4	0.3	1.1	3.0	-1.7	-0.4
Waist circumference	0.6	2.1	6.2	0.8	1.1	0.4	2.5	-0.3	-2.0
Number of incorrect matches in round	0.0	0.0	0.1	0.1	0.1	-0.3	0.1	-0.2	0.1
Past tobacco smoking	0.9	1.6	3.8	-1.5	0.4	-2.0	-1.7	0.9	0.0
Alcohol usually taken with meals	2.1	3.4	6.7	-2.1	-1.1	-2.5	-2.6	0.7	-0.9
Nervous feelings	0.3	0.6	2.2	1.5	-0.4	-0.7	-0.6	-0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	8.0	2.5	-1.9	1.5	1.1	-2.8	-1.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.1	0.6	0.5	0.5	-0.5	0.5
Hair/balding pattern: Pattern 2	0.9	1.1	3.5	0.7	-0.2	1.5	1.9	-0.2	0.2
Had menopause	1.0	1.3	3.8	-1.9	-0.3	-1.1	-0.9	-0.3	-1.3
Had other major operations	2.2	2.7	6.0	2.5	1.1	1.0	1.6	-2.0	-1.2
Forced vital capacity (FVC)	0.3	1.3	2.7	-0.6	-0.5	1.6	1.5	-1.4	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	3.3	-1.8	0.1	-1.3	-0.7	0.1	-1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.6	1.9	0.4	-0.6	-0.3	0.0	-0.4
Qualifications: None of the above	0.6	1.3	3.8	0.3	1.9	1.1	1.6	0.1	-0.2
Financial difficulties in last 2 years	2.5	3.4	5.4	0.9	1.1	2.2	2.3	-2.0	-2.0
Mouth/teeth dental problems	1.6	2.4	11.0	0.9	-0.1	1.6	3.3	-0.3	0.1
Heart attack	2.5	3.1	12.5	0.9	1.0	3.5	1.7	-1.1	0.5
Allergy	1.7	4.0	8.0	2.8	1.6	-0.2	2.1	2.8	-1.3
Pain all over the body in last month	3.2	3.4	5.9	2.4	0.6	1.9	2.4	-1.9	-1.1
Diabetes (self-reported)	1.0	1.6	4.4	0.6	-0.1	1.4	1.7	-2.1	-0.3
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	9.5	-1.4	-1.1	-0.1	-2.4	-1.7	3.1
Medication: Ramipril	0.2	0.3	0.9	1.0	0.4	-0.3	0.4	0.7	0.1
Medication: Simvastatin	0.8	1.2	5.7	1.0	0.2	0.6	0.2	-2.4	-0.2
Fluid intelligence score	1.3	2.7	12.0	-1.0	-1.0	-0.8	-1.1	3.5	0.7
Illnesses of siblings	1.1	1.5	3.6	-1.0	-1.2	-0.2	-1.4	1.9	1.1
Neuroticism score	0.4	0.9	3.1	1.8	-1.0	-0.2	-0.2	0.8	-0.7
Weight	0.6	2.8	9.2	1.3	0.7	0.8	3.0	-1.4	-1.6
Impedance of arm (right)	0.2	0.8	2.1	1.4	-0.3	-0.1	-0.6	-0.3	1.4
Arm fat percentage (right)	0.7	2.6	6.0	2.4	-0.3	0.9	2.4	-1.7	0.1
Trunk fat-free mass	0.3	2.0	7.6	-0.2	1.1	-0.3	1.7	-0.3	-2.8
Hip circumference	0.7	3.1	10.6	1.4	-0.3	1.4	3.3	-1.8	-0.5
Time employed in main current job	0.8	1.0	2.7	0.7	-0.1	0.3	0.7	-1.6	-1.4
Alcohol intake versus 10 years previously	1.7	2.5	4.5	-0.3	1.4	2.0	2.1	-1.8	-1.3
Father’s age at death	0.5	0.7	1.3	-1.1	-0.7	-0.3	-1.2	1.0	-0.3
Worrier / anxious feelings	0.7	1.3	2.8	0.0	-0.7	-1.6	-1.2	1.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	4.1	2.0	-0.3	1.4	1.9	-1.9	-1.4
Falls in the last year	0.2	0.3	0.6	-0.3	-0.8	0.4	-0.1	-0.8	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	-0.5	-0.8	0.7	-0.5	-0.7	-0.3
Number of live births	0.1	0.1	0.3	-0.5	0.4	-0.3	0.1	0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.3	0.8	2.4	0.4	-0.6	0.8	0.9	-1.5	-0.8
Pulse rate	0.5	0.8	2.1	1.4	-0.4	1.1	0.0	-1.3	0.1
Happiness	0.8	1.0	2.5	1.6	-0.1	1.1	1.5	-0.1	0.0
Noisy workplace	1.0	1.3	3.8	-0.2	-1.2	0.9	1.2	-2.0	0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.4	-0.1	-0.3	-1.6	-2.1	1.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.2	0.5	0.8	-1.4	-0.7	-0.5	-1.5
Mouth/teeth dental problems: Dentures	0.7	1.2	2.2	-1.1	-1.2	0.6	-1.0	-1.5	0.9
Asthma	1.6	3.2	10.1	-2.2	1.7	1.0	-0.1	-3.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.7	1.7	1.2	1.4	1.6	-1.1	0.7
Medication: Cholesterol lowering	0.5	0.8	1.8	0.9	1.4	0.7	0.4	-1.0	-0.5
Depression (self-reported)	0.2	0.3	0.6	0.6	-0.5	-0.5	-0.2	-0.8	-0.5
Medication: Lansoprazole	0.1	0.1	0.2	-0.2	0.1	-0.1	-0.3	0.5	-0.0
Prospective memory result	1.8	2.2	3.8	0.5	1.9	1.4	1.3	-1.9	-1.4
Lung cancer (father)	0.7	0.8	2.3	-1.2	-1.5	0.3	-0.3	1.0	0.6
Illnesses of mother	0.7	0.9	2.6	0.4	-0.5	1.5	0.3	0.5	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	1.7	0.6	-1.3	1.0	1.1	-1.2	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.0	-0.1	0.8	0.7	-1.2	-0.7
Impedance of arm (left)	0.2	1.0	3.2	1.3	-0.7	0.2	-0.5	-0.5	1.8
Arm fat mass (right)	0.6	2.6	8.0	1.9	0.1	1.1	2.8	-1.6	-0.6
Trunk predicted mass	0.3	1.9	7.4	-0.2	1.0	-0.3	1.7	-0.4	-2.7
Standing height	0.1	1.2	4.2	0.1	1.3	-0.4	1.1	0.2	-2.1
Length of working week for main job	0.1	0.1	0.3	0.4	-0.3	-0.6	0.1	0.2	-0.3
Exposure to tobacco smoke at home	1.7	2.0	5.6	1.3	0.9	1.4	2.4	-1.1	-0.7
Breastfed as a baby	1.2	1.4	4.7	1.1	0.9	-0.9	1.0	-0.4	-2.2
Tense / ‘highly strung’	1.3	2.2	5.9	2.4	0.7	1.4	1.8	-0.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.7	0.0	0.3	-0.2	0.4	0.0
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	0.0	-0.3	0.8	-0.2	1.1	1.2
Birth weight of first child	1.6	2.9	6.3	0.7	-1.9	-2.5	-2.0	1.2	-1.2
Peak expiratory flow (PEF)	0.1	0.2	0.8	-0.4	-0.1	-0.2	-0.9	-0.3	-0.6
Pulse wave reflection index	0.5	0.6	2.4	0.8	0.2	-0.5	0.5	0.0	-1.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.7	0.2	-0.2	-0.3	0.0	-0.1	-0.8
Loud music exposure frequency	0.4	0.4	1.4	-0.7	-1.2	0.5	0.5	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.9	1.7	0.1	-0.4	1.1	1.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	5.3	0.2	2.3	-0.1	-0.9	0.8	-0.3
Blood clot in the leg (DVT)	0.6	0.7	1.7	-0.5	-0.8	0.9	0.5	-1.0	-1.3
Medication: Paracetamol	1.9	3.1	6.8	1.3	-0.1	2.0	2.6	-2.5	-0.4
Headache pain in last month	2.0	3.4	8.4	2.2	1.2	1.3	1.8	-2.9	0.6
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	4.8	-2.1	-1.1	-2.2	-1.9	1.2	0.0
Glaucoma (self-reported)	1.2	1.4	3.1	1.5	-0.4	1.6	0.6	-1.8	-0.1
Gout (self-reported)	0.9	1.2	4.1	-0.2	0.6	1.0	-0.4	-1.2	2.0
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	7.7	2.8	0.7	1.2	2.1	0.5	0.2
Medication: Amlodipine	1.2	1.7	4.1	2.0	1.5	1.3	1.3	0.1	-0.3
Medication: Ventolin 100micrograms inhaler	1.8	2.3	6.3	-0.7	-0.1	0.2	-0.6	-2.5	2.5
Birth weight	1.3	2.9	7.3	2.7	1.4	1.1	2.0	-1.5	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	0.4	0.6	1.0	0.0	-1.3	0.8
High blood pressure (siblings)	1.1	1.6	3.1	1.4	0.7	0.7	1.8	-1.8	-0.8
Forced vital capacity (FVC), Best measure	0.4	1.3	2.6	-0.1	-0.7	1.5	1.6	-1.1	-1.2
Body fat percentage	0.7	2.8	6.6	2.5	0.1	1.1	2.6	-1.8	0.2
Leg fat percentage (right)	0.5	1.8	4.0	2.0	0.6	0.8	2.0	-1.4	-0.4
Arm fat-free mass (right)	0.4	2.0	6.6	-0.0	0.9	0.2	2.0	-0.9	-2.6
Exposure to tobacco smoke outside home	1.5	2.0	4.0	1.3	0.1	2.0	2.0	1.3	-0.8
Comparative body size at age 10	0.8	2.3	6.0	0.8	-0.2	2.3	2.4	-1.2	-0.4
Number of full brothers	0.2	0.3	0.6	0.2	-0.6	0.8	-0.2	-0.5	0.6
Worry too long after embarrassment	0.7	1.1	3.1	0.9	-0.5	-1.3	-0.7	1.8	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.0	0.4	0.5	-1.1	-0.8	1.3	-2.0
Wheeze or whistling in the chest in last year	0.9	1.6	4.9	-0.6	0.2	2.2	0.9	-1.8	0.6
Number of children fathered	2.0	2.3	6.8	1.0	1.5	1.8	2.6	-0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	3.3	1.7	-1.1	1.8	1.7	-0.3	1.1
Age at first live birth	2.7	4.9	8.8	-2.1	-1.6	-2.8	-3.0	2.3	0.1
Pulse wave peak to peak time	0.5	0.6	1.5	-0.9	0.3	-0.6	-0.5	1.2	0.6
Health satisfaction	2.1	2.7	6.1	1.6	1.1	1.5	2.5	-1.8	-0.9
Shortness of breath walking on level ground	0.7	0.8	1.8	-0.1	-0.4	1.4	1.2	-1.1	-0.6
Qualifications: College or University degree	0.9	3.0	7.9	-1.4	0.1	-1.8	-2.8	0.8	2.0
Eye problems/disorders: None of the above	0.5	0.6	1.4	-1.2	-0.9	-0.3	-0.2	1.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.4	-0.6	-0.9	0.3	-0.7	-1.8	0.8
Emphysema/chronic bronchitis	0.6	0.7	3.0	-0.1	-0.9	0.5	-0.1	-1.7	-0.2
Medication for pain relief, constipation, heartburn	1.9	3.2	8.8	-1.7	-0.9	-1.8	-1.8	3.0	-0.2
Neck or shoulder pain in last month	0.2	0.3	1.2	-0.4	0.3	-1.1	-0.3	-0.3	-0.4
Medication: Blood pressure	3.3	5.8	10.2	2.2	3.2	3.0	3.2	-0.4	0.3
Angina (self-reported)	1.1	1.5	5.1	-0.4	2.3	1.7	0.9	0.4	0.1
Migraine (self-reported)	1.2	1.5	2.8	1.6	1.7	0.6	1.5	-0.2	-0.9
Medication: Ibuprofen	1.5	1.8	3.2	1.8	1.1	1.3	1.8	-1.0	-0.2
Medication: Allopurinol	0.3	0.5	1.8	-0.5	0.4	1.4	0.5	-0.2	0.4
Medication: Omeprazole	0.5	0.7	1.9	0.7	1.4	-0.1	0.1	-0.6	-1.1
Medication: Seretide 50 evohaler	2.4	2.7	9.3	-0.2	1.2	3.0	2.2	-0.8	0.3
Mean time to correctly identify matches	1.8	3.5	6.7	-1.4	0.4	-2.6	-2.6	1.8	-1.5
Heart disease (mother)	0.4	0.5	0.9	-0.0	0.7	-1.0	-0.2	-0.9	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.9	0.0	0.3	1.7	1.3	-1.4	-0.2
Whole body fat mass	0.7	2.7	7.8	2.1	0.4	0.9	2.8	-1.6	-0.7
Leg fat mass (right)	0.6	2.5	6.4	1.8	0.6	0.9	2.5	-1.6	-1.2
Arm predicted mass (right)	0.4	2.1	7.3	0.1	0.7	0.0	1.9	-1.0	-2.7
Pulse rate, automated reading	0.3	1.0	2.2	0.9	0.2	1.5	0.4	-1.5	-0.5
Alcohol intake frequency.	0.6	1.4	5.2	-2.3	-0.5	0.2	0.4	-1.5	-0.3
Comparative height size at age 10	0.3	1.9	3.8	-0.3	1.8	0.6	1.9	-0.9	-1.8
Number of full sisters	3.0	3.7	7.5	2.1	1.4	1.8	2.7	-2.2	0.4
Suffer from ‘nerves’	0.5	0.9	2.7	0.4	-1.1	0.5	0.9	0.1	-1.6
Overall health rating	4.5	9.7	19.1	2.8	2.3	4.1	4.4	-3.0	-0.7
Chest pain or discomfort	0.9	1.3	2.6	0.3	1.6	1.6	1.3	-0.9	-0.3
Had major operations	0.9	1.1	1.8	1.3	-1.0	1.0	0.9	-0.6	1.3
Age at last live birth	1.8	2.6	4.6	-1.1	-1.1	-2.0	-2.2	2.1	-0.5
Family relationship satisfaction	1.9	2.4	5.5	2.0	1.1	1.4	2.4	0.7	-1.1
Leg pain on walking	0.3	0.4	1.7	0.3	0.2	0.7	0.3	-0.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	5.7	-2.4	-0.3	-0.7	-0.0	0.5	0.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	0.1	-0.1	-1.1	-0.7	-0.8	-0.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.1	-0.6	-1.6	-0.3	-0.5	1.8	1.3
Medication: Aspirin	1.0	1.3	2.0	-0.4	1.3	1.4	0.5	-1.4	1.3
Supplements: Vitamin C	1.4	1.6	3.6	1.2	1.9	1.0	1.8	-0.0	-0.7
Knee pain experienced in last month	0.3	0.5	1.7	0.7	1.3	-0.2	0.1	-0.4	-0.8
Hypertension (Self-reported)	1.1	3.0	6.9	1.8	2.1	1.3	2.6	0.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	6.9	0.7	2.6	0.2	0.9	-0.9	-1.2
Illnesses of father: Heart disease	0.5	0.7	1.3	-0.6	1.2	-0.8	-0.9	-0.8	-0.3
Illnesses of siblings: Diabetes	1.4	1.8	4.5	1.0	0.0	0.6	1.8	-2.1	-1.2
Smoking status: Previous	0.8	1.2	2.5	1.6	-0.0	1.6	1.2	-0.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	3.3	0.7	0.9	1.0	1.8	-0.8	-1.8
Whole body fat-free mass	0.3	1.8	5.5	0.1	0.8	0.1	2.1	-0.7	-2.4
Leg fat-free mass (right)	0.3	1.6	5.0	0.5	0.3	0.2	2.2	-0.9	-1.9
Arm fat percentage (left)	0.7	2.7	5.9	2.3	-0.6	1.1	2.4	-1.9	0.2
Average weekly red wine intake	0.4	0.7	1.6	-1.3	-1.1	-0.0	-0.8	-0.3	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	-0.9	-0.7	-0.5	-0.1	0.7	1.1
Mood swings	0.4	0.7	1.8	1.2	-0.3	-0.3	-0.4	-1.3	-0.7
Loneliness, isolation	1.9	2.7	4.7	1.5	-0.1	2.1	2.2	-1.4	-1.5
Long-standing illness, disability or infirmity	4.7	7.2	13.1	1.9	2.3	3.6	3.2	-3.1	-1.2
Ever had bowel cancer screening	0.9	1.0	3.3	1.8	0.9	1.1	0.7	-0.2	-0.6
Diabetes diagnosed by doctor	0.7	1.2	2.3	1.5	0.2	0.7	1.5	-1.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.1	-1.0	1.3	0.6	0.4	-1.4	0.1
Friendships satisfaction	1.9	2.4	4.8	0.3	1.5	1.5	2.2	1.1	-1.9
Qualifications: nursing, teaching	0.9	1.4	2.6	1.2	-0.4	-1.6	-1.5	0.0	-1.4
Commuting to job workplace: Walk	1.0	1.1	2.8	-0.0	-1.7	-1.2	-1.2	0.1	0.9
Eye problems/disorders: Cataract	0.8	0.9	3.4	1.9	0.6	-0.4	-0.7	-0.9	0.3
Mouth/teeth dental problems: Mouth ulcers	4.5	7.1	19.3	-1.7	-1.3	-2.8	-4.4	2.2	2.4
Medication for cholesterol	0.5	0.7	2.1	-0.5	-1.5	-0.1	-0.1	1.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	3.1	-0.4	-0.0	-0.4	-0.9	-1.8	1.6
Back pain experienced in last month	0.9	1.3	3.3	-1.8	-1.1	0.4	0.1	-1.6	-0.9
Mineral and other dietary supplements	1.4	1.9	5.1	0.6	0.8	2.2	1.9	-1.0	-0.9
Breast cancer (self-reported)	2.0	2.4	6.8	-1.7	-0.9	-1.4	-1.2	2.6	-0.7
Asthma (self-reported)	1.6	3.2	10.1	-2.2	1.7	1.2	0.1	-3.2	0.1
Osteoporosis (self-reported)	0.9	1.1	3.7	1.9	0.1	0.2	1.0	0.8	0.9
Osteoarthritis (self-reported)	3.1	4.0	8.1	2.8	1.0	2.2	2.4	-2.0	0.6
Medication: Aspirin	0.7	0.9	1.7	-0.8	1.3	0.8	-0.3	-0.8	1.3
Medication: Gliclazide	0.7	0.7	2.8	0.5	0.4	0.9	1.7	0.5	-0.5
Illnesses of father: None of the above (group 1)	1.0	1.3	4.6	0.2	-2.2	-0.7	-0.3	1.4	0.7
Smoking status: Current	0.6	1.0	3.9	-1.0	-2.0	-0.1	-0.7	-0.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.8	-0.1	0.1	0.9	0.8	-0.4	0.7
Whole body water mass	0.4	2.0	5.5	0.2	0.8	0.2	2.3	-0.8	-2.4
Leg predicted mass (right)	0.3	1.7	5.2	0.5	0.3	0.3	2.3	-0.9	-2.0
Arm fat mass (left)	0.7	2.8	8.2	2.0	-0.2	1.0	2.9	-1.8	-0.5
Number of self-reported non-cancer illnesses	1.5	2.7	5.5	1.3	2.3	2.2	1.6	-0.8	-0.9
Average weekly champagne plus white wine intake	1.3	1.8	4.3	0.7	-0.5	-2.1	-1.5	1.7	0.8
Miserableness	0.6	1.0	3.5	1.2	-1.9	-0.1	-0.8	0.1	0.5
Guilty feelings	0.9	1.3	4.9	1.1	-2.2	-0.8	-1.1	0.0	-0.0
Wears glasses or contact lenses	1.3	1.5	2.6	0.5	1.5	-1.6	-1.1	1.6	0.2
Ever taken oral contraceptive pill	1.4	1.6	6.2	1.1	-2.5	-1.1	-0.7	-0.7	0.1
Hearing aid user	1.3	1.5	3.7	0.0	-1.9	-1.3	-1.5	0.9	0.8
Mother’s age at death	0.7	0.8	2.2	-0.2	-1.2	-1.5	-1.0	0.4	0.5
Financial situation satisfaction	2.5	3.0	8.5	0.8	0.4	2.0	2.9	-1.9	-1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.7	0.7	0.2	0.8	1.6	-0.9	0.8
Commuting to job workplace: Public transport	0.4	0.5	1.1	0.6	-1.0	0.6	-0.6	-0.2	1.0
Eye problems/disorders: Glaucoma	0.9	1.0	3.4	0.8	-1.9	0.5	-0.5	-1.2	0.5
Medication: Blood pressure	0.5	1.0	2.5	0.9	1.0	-1.2	0.0	-0.4	-1.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.7	-0.9	-1.6	-1.3	-1.9	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.0	-1.2	-1.3	-2.0	-1.7	0.1	1.3
High cholesterol (Self-reported)	0.4	0.7	1.5	0.8	0.7	-0.6	0.0	-1.0	-1.2
Medication: Bendroflumethiazide	0.2	0.2	0.4	0.3	0.3	-0.4	0.6	-0.6	-0.6
Medication: Paracetamol	1.0	1.5	3.4	1.1	-0.3	1.5	1.9	-1.4	-0.2
Medication: Lisinopril	0.4	0.5	1.4	-0.1	-1.2	-0.4	-1.0	-0.7	-0.1
Medication: Atorvastatin	0.5	0.6	1.7	-0.5	0.7	1.3	0.5	-0.3	-0.9
Illnesses of father: High blood pressure	1.8	2.2	4.8	1.0	1.0	2.1	2.2	-1.4	-0.3
Alcohol drinker status: Never	0.4	0.5	1.3	-1.2	1.1	0.1	0.6	-0.1	-0.5
Ever smoked	0.4	0.8	2.2	0.5	-1.5	1.1	0.6	-0.8	-0.1
Basal metabolic rate	0.4	2.1	6.3	0.4	0.8	0.4	2.5	-0.9	-2.1
Leg fat percentage (left)	0.4	1.4	3.7	1.9	0.4	0.5	1.7	-1.1	-0.3
Arm fat-free mass (left)	0.4	2.2	6.2	0.3	0.9	0.0	2.3	-0.6	-2.5
Number of operations (self-reported)	0.7	1.0	3.3	1.8	-0.3	1.0	0.9	-1.0	0.1
Average weekly beer plus cider intake	0.8	1.2	4.5	2.1	0.1	0.4	1.3	0.3	0.9
Irritability	0.9	1.5	4.6	2.1	0.9	1.1	1.3	-0.4	-0.7
Risk taking	0.1	0.1	0.5	-0.2	0.7	0.1	0.2	0.1	-0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-0.5	-0.4	0.5	-0.5	1.1	1.2
Fractured/broken bones in last 5 years	1.0	1.3	3.8	0.1	1.2	1.0	1.3	-1.9	-0.0
Age started oral contraceptive pill	0.7	0.9	2.0	-0.7	1.1	-1.4	-0.9	0.7	-0.4
Diastolic blood pressure, automated reading	0.8	2.5	8.6	1.4	2.9	0.5	2.0	0.4	0.0
Ever depressed for a whole week	0.8	0.9	2.4	1.6	0.2	-1.4	-0.1	-0.1	-1.1
Unable to work because of sickness or disability	2.5	3.3	7.0	-0.0	0.3	2.6	2.4	-1.8	-2.0
Commuting to job workplace: Cycle	0.3	0.4	1.6	-0.3	-0.2	-0.1	0.6	1.3	0.1
Myopia	0.3	0.4	1.4	-0.4	-1.2	0.1	0.5	1.0	-0.1
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.1	-1.6	-1.7	-1.4	-2.2	-0.1	1.1
Cholesterol lowering medication	0.6	0.9	3.6	-0.3	1.1	0.3	0.3	-1.9	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.1	1.3	1.1	0.4	0.7	-1.5	-1.4
Pain experienced in last month	1.3	2.1	4.0	-1.5	-0.6	-0.7	-1.4	2.0	1.9
Supplements: Calcium	0.6	0.7	2.7	-1.6	-0.7	0.6	0.1	0.5	0.6
Basal cell carcinoma (self-reported)	0.9	1.1	2.4	0.1	0.3	1.5	1.0	-1.4	-1.0
Heart attack/myocardial infarction (self-reported)	2.0	2.6	10.0	1.0	1.1	3.2	1.6	-0.8	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.3	-0.5	-1.1	0.9	0.4	-0.9	-1.0
Heart disease (siblings)	0.5	0.6	2.0	1.1	1.4	0.3	0.2	-0.5	0.3
Alcohol drinker status: Previous	0.7	0.8	1.9	-1.3	-1.4	-0.9	-0.5	0.4	-0.5
Pack years of smoking	0.1	0.1	0.7	-0.0	-0.1	0.0	0.1	0.2	0.8
Impedance of whole body	0.2	0.8	2.2	0.9	-0.8	-0.1	-1.1	-0.1	1.5
Leg fat mass (left)	0.5	2.1	5.3	1.8	0.5	0.7	2.3	-1.5	-1.0
Arm predicted mass (left)	0.4	2.2	6.1	0.1	1.1	0.1	2.3	-0.7	-2.5