TWAS hub - TP53BP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0240	0.0150	6.8e-03	0.006	NA	0.030	NA	0.020	9.1e-02	NA	1.5e-03	NA	8.4e-03
2	GTEx	Cells Transformed fibroblasts	0.0650	0.0310	1.1e-05	0.083	NA	0.053	NA	0.071	8.7e-07	NA	7.9e-05	NA	5.3e-06
3	GTEx	Esophagus Muscularis	0.0580	0.0320	1.0e-03	0.011	NA	0.016	NA	0.024	6.6e-02	NA	3.4e-02	NA	1.3e-02
4	METSIM	Adipose	0.0371	0.0201	3.3e-04	0.028	0.024	0.021	0.025	0.027	3.5e-05	0.00013	3.0e-04	0.00011	5.8e-05
5	TCGA	Prostate Adenocarcinoma	0.1040	0.1157	6.6e-03	0.001	0.011	0.041	NA	0.018	2.7e-01	0.02300	4.1e-05	NA	4.4e-03
6	TCGA	Skin Cutaneous Melanoma	0.5360	0.1860	8.6e-03	-0.004	0.027	-0.001	NA	0.018	4.4e-01	0.06400	3.5e-01	NA	1.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Triglycerides	7.7	12.6	21.5	-3.8	-4.1	-4.6	-3.6	-2.3	-2.1
Body Mass Index (BMI) (2010)	7.5	10.3	15.4	3.6	3.9	3.0	3.7	1.9	2.8
Illnesses of siblings: Diabetes	7.0	8.6	13.2	3.6	2.8	3.5	2.9	2.7	1.6
Lung cancer (father)	6.6	7.7	14.6	2.3	2.8	3.8	3.3	2.7	-0.8
Alcohol drinker status: Never	6.2	7.5	16.6	2.3	3.1	2.8	4.1	2.0	1.3
Age at First Birth	5.8	8.4	11.3	-3.3	-2.9	-3.3	-3.4	-2.9	-0.6
Blood Platelet Count	5.6	65.4	92.3	-9.4	-9.4	-9.6	-7.9	-5.2	-5.9
Lupus	4.9	7.5	12.5	-2.5	-3.0	-3.4	-3.5	-2.3	-0.2
Mouth/teeth dental problems: Bleeding gums	4.5	5.8	16.3	2.1	1.9	2.3	2.2	4.0	0.2
Financial difficulties in last 2 years	4.4	5.9	9.8	3.1	2.5	2.0	2.6	2.6	1.5
Vitamin and mineral supplements	4.3	5.8	8.0	2.8	2.0	2.6	2.8	2.8	0.4
Loud music exposure frequency	4.3	4.7	9.7	1.6	1.5	2.5	2.5	3.1	-1.0
Schizophrenia (2014)	4.2	9.2	18.3	2.9	2.0	4.3	2.9	4.0	-0.7
Ovarian Cancer	4.0	5.3	9.2	-2.9	-1.3	-3.0	-1.8	-2.8	1.1
Exposure to tobacco smoke outside home	4.0	5.4	9.8	2.6	1.6	2.7	2.5	3.1	-0.7
Diabetes (father)	3.7	4.6	9.2	3.0	2.2	2.6	1.7	1.6	1.1
Multivitamins +/- minerals	3.7	4.7	7.1	-2.4	-2.1	-2.1	-2.7	-2.3	-0.9
Schizophrenia (2018)	3.6	7.4	15.4	2.5	1.7	3.9	2.4	3.7	-0.6
Supplements: Zinc	3.6	4.0	6.1	-2.2	-2.5	-2.2	-2.3	-0.1	-1.7
Shortness of breath walking on level ground	3.3	3.9	6.5	2.5	2.3	2.0	2.1	1.5	1.3
Age at first live birth	3.2	5.7	7.3	-2.5	-2.7	-2.4	-2.6	-2.7	-1.0
Major Depression (MDD)	3.0	3.6	7.9	2.1	1.4	2.8	1.7	2.2	-0.1
Medication: Omeprazole	3.0	3.6	4.7	2.1	2.2	1.9	1.8	1.5	1.7
Diverticular disease/diverticulitis (self-reported)	2.9	3.4	7.6	1.0	1.2	2.8	2.1	1.9	-1.5
Impedance of arm (right)	2.9	13.4	17.5	-3.7	-3.8	-4.2	-4.1	-3.9	-1.6
Number of full brothers	2.9	3.7	9.5	2.1	0.8	3.1	1.8	2.0	-0.6
Neck or shoulder pain in last month	2.9	4.2	8.3	1.8	1.7	2.9	2.3	2.3	-0.7
Crohns Disease (2012)	2.8	4.5	7.1	-2.7	-2.0	-2.3	-2.0	-2.6	-0.1
Blood Red Count	2.7	26.4	44.8	6.7	5.4	5.4	4.2	5.6	2.6
Body mass index (BMI)	2.7	11.7	23.5	4.8	3.4	3.5	3.2	3.1	1.7
Qualifications: None of the above	2.7	5.8	11.9	2.6	2.7	3.4	2.6	1.4	0.1
Medication: Ramipril	2.7	3.5	5.9	-1.9	-2.4	-2.1	-1.9	-1.0	-1.6
Alcohol intake frequency.	2.7	6.3	13.0	2.9	1.8	3.6	3.0	1.8	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	10.5	1.5	1.1	2.2	1.5	3.2	-0.5
Impedance of whole body	2.7	13.5	19.4	-4.2	-3.9	-4.4	-4.2	-2.7	-1.9
Bipolar Disorder or Schizophrenia	2.6	6.3	15.2	2.5	1.9	3.9	2.3	2.7	-0.2
Father’s age at death	2.6	3.5	10.0	-3.2	-1.4	-2.1	-0.5	-1.9	-0.7
Exposure to tobacco smoke at home	2.6	2.9	6.2	-0.8	-2.2	-1.5	-2.5	-1.2	-1.4
Tense / ‘highly strung’	2.6	4.3	19.2	-1.1	-1.6	1.5	0.7	0.3	-4.4
Blood clot in the leg (DVT)	2.5	3.2	9.1	1.5	0.9	2.2	1.3	3.0	-0.6
Arm fat mass (left)	2.5	10.4	21.3	4.6	3.4	3.1	3.2	2.3	2.1
Impedance of leg (right)	2.4	11.6	18.3	-4.3	-3.6	-4.0	-3.8	-2.0	-1.9
Age at last live birth	2.4	3.5	5.4	-1.8	-2.2	-2.3	-1.9	-2.0	-0.6
Hip circumference	2.3	9.8	22.0	4.7	3.1	3.3	2.8	2.1	1.9
Impedance of arm (left)	2.3	10.8	15.3	-3.5	-3.2	-3.9	-3.6	-3.4	-1.1
Age started oral contraceptive pill	2.3	2.8	6.8	-0.6	-2.1	-0.9	-2.6	-1.6	-1.4
BMI	2.2	13.0	25.7	5.1	3.4	4.3	3.4	3.1	1.1
Chronotype (morning person)	2.2	5.2	7.5	-2.3	-2.7	-1.8	-1.9	-2.1	-2.7
Average weekly fortified wine intake	2.2	2.5	4.3	-1.8	-2.1	-1.3	-1.7	-1.7	-0.5
High blood pressure	2.2	6.1	10.5	-1.7	-3.2	-2.5	-3.2	-0.9	-2.3
Impedance of leg (left)	2.2	10.5	16.5	-4.1	-3.5	-3.9	-3.8	-1.1	-1.8
Waist circumference	2.2	8.0	17.6	4.2	2.5	3.3	2.6	2.5	0.7
Arm fat mass (right)	2.2	9.2	19.3	4.4	3.1	3.0	2.9	2.1	1.9
Supplements: Fish oil (including cod liver oil)	2.2	2.8	6.6	-1.6	-1.6	-2.1	-2.6	-1.0	-0.2
Leg fat mass (left)	2.2	8.5	17.5	4.2	2.7	3.0	2.7	3.0	1.2
HDL Cholesterol	2.1	3.5	8.2	2.1	1.6	2.9	1.8	1.6	0.4
Hearing aid user	2.1	2.4	6.5	0.9	1.6	2.5	2.1	0.5	-0.0
Townsend deprivation index at recruitment	2.0	2.7	6.6	2.6	0.6	2.2	0.7	1.9	-0.7
Arm predicted mass (right)	2.0	10.0	14.9	3.8	3.5	3.4	3.9	2.0	1.8
Hypertension (Self-reported)	2.0	5.4	9.5	-1.5	-3.0	-2.4	-3.1	-1.0	-2.2
Vascular/heart problems diagnosed by doctor	2.0	5.6	10.8	1.5	3.1	2.6	3.3	0.7	1.9
Weight	1.9	9.2	19.7	4.4	3.1	3.2	3.1	1.9	1.7
Arm fat-free mass (right)	1.9	9.8	14.5	3.6	3.5	3.3	3.8	2.2	1.9
Arm fat-free mass (left)	1.9	9.5	13.6	3.7	3.4	3.2	3.6	1.9	2.2
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.1	1.8	1.7	1.6	1.3	0.9	1.6
Alcohol drinker status: Previous	1.9	2.2	7.7	0.6	-1.4	1.5	-0.8	-0.2	-2.8
Illnesses of siblings	1.8	2.5	5.6	-1.4	-1.4	-2.4	-1.5	-1.8	0.2
Leg fat mass (right)	1.8	7.0	14.7	3.8	2.4	2.9	2.5	2.5	0.9
Number of full sisters	1.8	2.2	6.0	-1.9	-0.2	-2.5	-0.9	-0.6	1.5
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.2	-2.0	-1.3	-1.8	-1.5	-1.3	-0.3
Mineral and other dietary supplements	1.8	2.4	6.2	1.6	1.8	1.2	2.5	0.9	0.8
Arm predicted mass (left)	1.8	9.3	13.8	3.7	3.3	3.2	3.5	1.9	2.1
Worry (Nagel 2018)	1.7	3.6	14.7	-1.2	-2.2	0.2	-0.7	0.3	-3.8
Breast Cancer	1.7	4.0	13.4	-1.9	-1.1	-3.7	-2.0	-0.6	1.4
Number of incorrect matches in round	1.7	2.8	5.2	1.3	2.3	1.5	2.2	-0.2	1.7
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.6	-1.4	-1.9	-0.5	-1.8	-1.8	-0.8
Arm fat percentage (left)	1.7	7.0	17.2	4.1	2.7	2.2	2.2	2.0	1.8
Tinnitus: Yes, now most or all of the time	1.7	1.9	3.9	1.4	1.7	2.0	1.5	0.2	0.8
Basal metabolic rate	1.7	9.6	16.0	4.0	3.3	3.4	3.6	1.4	1.9
Diastolic blood pressure, automated reading	1.7	5.1	9.9	-1.6	-1.5	-3.1	-2.7	-2.8	0.8
Hearing difficulty/problems: Yes	1.6	2.4	5.1	1.0	1.4	2.3	1.7	1.9	-0.4
Leg fat-free mass (left)	1.6	8.3	15.6	3.9	3.0	3.3	3.3	0.9	1.7
Leg predicted mass (left)	1.6	8.6	15.8	4.0	3.1	3.3	3.4	0.9	1.8
Hearing difficulty/problems with background noise	1.6	2.5	5.1	1.4	1.8	2.3	1.6	1.4	0.6
Mouth/teeth dental problems	1.6	2.5	8.2	-1.3	-0.7	-1.8	-1.0	-2.9	0.7
Birth weight of first child	1.6	2.8	6.3	1.5	2.0	1.9	2.5	0.9	0.1
Suffer from ‘nerves’	1.6	2.5	10.3	0.4	-1.0	1.9	0.3	0.3	-3.2
Whole body fat-free mass	1.6	8.9	13.8	3.7	3.2	3.4	3.6	1.1	1.9
Leg fat-free mass (right)	1.6	8.6	15.4	3.9	3.0	3.4	3.4	1.2	1.7
Loneliness, isolation	1.6	2.2	10.1	0.2	-1.4	0.9	-0.6	0.0	-3.2
Whole body water mass	1.6	9.1	13.7	3.7	3.3	3.4	3.7	1.2	1.9
Leg predicted mass (right)	1.6	8.8	15.7	4.0	3.1	3.4	3.4	1.2	1.7
Medication: Lisinopril	1.6	2.1	6.1	-0.5	1.1	-1.6	0.4	1.5	2.5
Blood Eosinophil Count	1.5	11.5	45.7	2.1	2.9	-2.8	0.2	1.6	6.8
Trunk fat mass	1.5	6.2	15.6	4.0	2.5	2.4	2.2	1.9	1.3
Hair/balding pattern: Pattern 3	1.5	2.2	5.2	2.3	0.4	2.1	1.1	1.2	-0.8
Trunk predicted mass	1.5	8.7	14.2	3.3	3.3	3.4	3.8	1.1	1.9
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.0	-1.3	-1.8	-2.0	-2.0	-1.1	0.1
Overall health rating	1.5	3.2	7.2	2.5	1.2	2.7	1.3	1.3	-0.9
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.2	-1.3	-1.8	-0.6	-1.7	-0.7	-1.5
Medication: Gliclazide	1.5	1.6	4.9	0.8	1.6	-0.9	0.9	-0.2	2.2
Medication: Blood pressure	1.5	2.9	5.9	-0.9	-1.9	-2.4	-2.3	-0.8	-0.9
Leg fat percentage (left)	1.5	5.5	12.8	3.6	2.0	1.9	1.6	3.0	0.9
Intelligence (Savage-Jansen 2018)	1.4	4.2	9.4	-2.9	-1.7	-3.1	-1.9	-0.7	0.2
Hand grip strength (left)	1.4	3.8	6.5	2.5	2.1	0.6	2.1	1.6	2.1
Hand grip strength (right)	1.4	3.8	5.1	2.1	2.1	0.5	2.1	2.2	2.0
Maternal smoking around birth	1.4	2.0	7.5	0.2	-0.4	1.8	0.6	0.6	-2.7
Neuroticism score	1.4	3.0	11.8	-0.9	-2.1	0.3	-0.6	-0.6	-3.4
Arm fat percentage (right)	1.4	5.5	15.1	3.9	2.3	2.1	1.8	1.6	1.6
Trunk fat-free mass	1.4	8.1	13.3	3.2	3.2	3.3	3.6	1.0	1.8
Medication: Amlodipine	1.4	2.0	3.9	-0.9	-1.9	-0.0	-1.7	-1.0	-2.0
Whole body fat mass	1.4	5.9	14.2	3.8	2.3	2.3	2.2	2.0	1.2
Osteoporosis (self-reported)	1.4	1.7	5.1	0.7	1.1	2.3	1.7	0.5	0.1
Irritability	1.4	2.4	6.7	-1.2	-2.1	-0.2	-0.8	-1.1	-2.6
Neuroticism (Nagel 2018)	1.3	3.0	12.7	-1.1	-1.9	1.0	0.0	-0.1	-3.6
Prostate Cancer	1.3	1.8	2.8	1.1	1.6	1.7	1.0	1.6	0.5
Neuroticism (2016)	1.3	1.9	6.2	-1.0	-1.8	-0.4	-0.6	-0.4	-2.5
Type 2 Diabetes (T2D) (2018)	1.3	2.4	4.8	2.2	1.6	1.4	1.3	1.3	1.3
Neuroticism	1.3	3.2	11.5	-1.4	-2.2	0.1	-0.9	-0.4	-3.4
Medication: Metformin	1.3	1.8	3.8	2.0	1.3	0.5	1.3	0.6	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.2	1.7	1.2	1.6	1.7	1.8	-0.2
Peak expiratory flow (PEF)	1.3	2.9	11.2	0.2	1.7	-0.9	1.4	0.8	3.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.4	1.1	1.3	2.3	2.0	0.3	-0.1
Migraine (self-reported)	1.3	1.6	3.9	-0.9	-1.9	0.3	-1.0	-0.7	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	4.5	-1.6	-1.6	-2.1	-1.8	-1.7	0.0
Primary Biliary Cirrhosis	1.2	1.7	4.4	0.8	1.6	0.3	1.4	0.7	2.1
Angina	1.2	1.5	3.5	-1.9	-1.3	-1.3	-1.0	0.4	-1.1
Relative age voice broke	1.2	1.8	4.1	-0.6	-1.5	-1.0	-1.8	0.2	-2.0
Qualifications: CSEs or equivalent	1.2	1.6	4.2	2.0	1.0	0.4	1.2	1.5	0.6
Nervous feelings	1.2	2.3	7.8	-0.8	-2.1	-0.2	-0.8	-0.5	-2.8
Medication: Ibuprofen	1.2	1.4	4.0	0.8	1.7	0.6	2.0	0.5	0.5
Mean time to correctly identify matches	1.2	2.3	7.2	-1.8	-0.8	-2.7	-1.1	-1.2	0.6
Medication for cholesterol	1.2	1.8	3.3	0.9	1.8	1.0	1.8	0.6	1.6
Medication: Bendroflumethiazide	1.2	1.8	4.6	-0.4	-1.1	-2.1	-2.0	-0.8	0.2
Commuting to job workplace: Cycle	1.2	1.4	5.5	-2.3	-1.0	-0.9	-0.5	-0.6	-0.7
Supplements: Calcium	1.2	1.3	4.7	-0.8	-0.9	1.1	-0.5	-0.4	-2.2
Depression (Nagel 2018)	1.1	1.7	4.7	0.1	0.5	2.2	1.5	0.6	-1.6
Alzheimer’s Disease (in mother)	1.1	1.3	4.1	2.0	0.1	1.3	0.0	1.2	-0.7
Verbal and Numeric Reasoning (VNR)	1.1	2.5	8.8	-3.0	-1.6	-1.3	-1.1	-0.6	-0.8
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.6	0.8	0.2	1.9	1.4	0.7	-1.7
Serious illness, injury or assault to yourself	1.1	1.3	5.4	0.4	0.5	2.3	1.2	0.4	-0.7
Body fat percentage	1.1	4.2	12.1	3.5	1.9	1.6	1.4	2.0	1.1
Leg fat percentage (right)	1.1	3.8	9.8	3.1	1.6	1.7	1.4	2.3	0.5
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.5	0.6	-1.5	0.3	-1.3	0.8	-1.6
Average weekly red wine intake	1.1	1.6	2.9	-1.7	-0.4	-1.7	-0.7	-1.2	1.3
Wears glasses or contact lenses	1.1	1.3	2.9	-1.3	0.4	-1.2	0.1	-1.7	1.1
Alzheimer’s Disease (including proxy)	1.0	1.4	3.9	2.0	0.5	1.7	0.9	0.9	-0.4
Fasting Glucose	1.0	1.1	2.2	0.7	0.6	-0.3	1.5	-1.5	1.3
HbA1C	1.0	1.1	2.6	0.0	0.3	1.6	1.6	-0.2	-1.2
Systolic Blood Pressure	1.0	5.1	9.2	-2.0	-1.7	-3.0	-2.3	-3.0	-0.0
Relative age of first facial hair	1.0	2.0	4.2	-1.1	-1.7	-1.1	-1.5	-0.6	-2.0
Medication: Co-codamol	1.0	1.1	1.9	1.4	1.0	1.3	0.8	1.1	0.5
Trunk fat percentage	1.0	4.0	11.8	3.4	2.0	1.5	1.4	1.6	1.2
Current tobacco smoking	1.0	1.7	3.8	2.0	1.1	1.1	0.4	1.9	0.5
Age when periods started (menarche)	1.0	2.5	5.1	-2.3	-1.7	-1.9	-1.7	-0.5	0.2
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.7	2.0	1.5	2.2	0.9	0.2	1.0
Depression (self-reported)	1.0	1.2	4.4	-0.0	-1.1	0.1	-0.7	1.0	-2.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	5.9	0.6	0.7	0.2	0.4	2.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.9	1.1	1.4	0.2	1.0	0.1	1.7
Diabetes diagnosed by doctor	1.0	1.6	2.9	1.7	1.2	0.0	0.9	1.5	1.6
Osteoarthritis (self-reported)	1.0	1.3	2.8	0.5	1.2	0.4	0.6	-1.7	1.6
Crohns Disease (2017)	0.9	1.9	2.9	-1.4	-1.7	-1.0	-1.5	-1.7	-0.7
Bipolar Disorder (2011)	0.9	0.9	4.5	0.0	0.4	2.1	0.4	-0.8	-0.1
Mean Putamen Volume	0.9	1.0	2.0	-1.3	-1.1	-0.5	-0.9	-1.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.1	1.8	1.0	1.2	0.1	0.2	0.7
Breastfed as a baby	0.9	1.1	2.4	-1.0	-1.3	-1.2	-1.6	0.0	0.0
Angina (self-reported)	0.9	1.2	3.2	-1.8	-1.0	-1.3	-0.6	0.2	-0.8
Long-standing illness, disability or infirmity	0.9	1.4	3.0	1.6	0.4	1.7	0.7	1.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	5.2	-2.3	-0.0	-0.5	0.2	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	6.1	-1.7	-0.7	-0.9	-1.2	-2.5	0.4
Ever depressed for a whole week	0.9	1.2	4.1	0.6	0.6	1.1	0.7	2.0	-0.7
Reaction Time	0.8	1.5	5.8	-0.8	-0.0	-2.4	-0.5	-0.1	1.6
Systolic blood pressure, automated reading	0.8	2.3	7.5	-1.2	-1.0	-0.9	-1.6	-2.7	-0.7
Fed-up feelings	0.8	1.4	5.2	0.4	-1.1	1.2	0.3	-0.5	-2.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.5	0.8	0.4	1.4	0.7	1.6	-0.6
Diabetes (self-reported)	0.8	1.3	3.3	1.8	1.0	0.5	0.8	1.3	1.0
Pulse rate	0.8	1.3	4.3	0.7	0.9	-0.3	1.1	2.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.4	0.8	1.5	0.1	1.4	-0.0	0.9
Comparative body size at age 10	0.8	2.2	6.5	0.5	1.8	0.6	1.4	-0.8	2.6
Worry too long after embarrassment	0.8	1.3	3.1	-0.9	-1.6	-0.6	-0.9	-0.5	-1.8
Eye problems/disorders: None of the above	0.8	1.0	4.3	-0.7	-0.9	-0.2	-0.1	-0.4	-2.1
Medication for pain relief, constipation, heartburn	0.8	1.4	3.3	-0.4	-1.6	0.2	-1.2	-0.8	-1.8
Commuting to job workplace: Walk	0.8	0.8	3.2	-0.8	0.1	-0.8	-0.1	-1.8	0.7
Eye problems/disorders: Glaucoma	0.8	0.9	1.5	0.3	1.1	0.8	1.1	0.9	1.2
Cholesterol lowering medication	0.8	1.2	3.0	-1.1	-1.3	-0.6	-0.8	-0.5	-1.7
Pack years of smoking	0.8	1.2	3.3	1.2	0.6	1.8	0.9	0.9	-0.6
Irritable Bowel Disease (IBD)	0.7	1.7	3.6	-0.5	-1.6	0.3	-1.1	-1.9	-1.6
Heel T-Score	0.7	5.4	8.4	-2.9	-2.0	-2.5	-2.4	-2.8	-0.5
Cardiovascular Disease	0.7	2.4	4.5	-0.7	-2.1	-2.1	-1.8	-0.1	-1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.8	1.4	-0.2	0.2	-1.1	-0.6	1.0
Time employed in main current job	0.7	0.8	2.0	-0.8	-0.9	0.8	-0.0	-0.8	-1.4
Medication: Allopurinol	0.7	0.9	1.7	1.1	1.1	0.7	0.8	1.3	0.5
Medication: Seretide 50 evohaler	0.7	0.8	2.6	-0.3	-0.2	-1.1	-1.0	-0.2	1.6
Heart disease (mother)	0.7	0.8	1.7	0.3	0.5	1.3	1.2	0.6	-1.1
Family relationship satisfaction	0.7	0.9	1.7	1.3	0.1	1.3	0.4	1.1	-0.9
Illnesses of father: Heart disease	0.7	0.9	2.4	-0.8	-1.6	-0.2	-1.4	0.0	-0.8
Back pain experienced in last month	0.7	1.0	3.9	-0.1	-0.7	1.1	0.6	0.3	-2.0
Guilty feelings	0.7	1.0	2.4	-0.2	-1.4	0.1	-1.1	-0.5	-1.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	1.6	1.1	0.4	0.7	-0.4	1.1
Depressed Affect (Nagel 2018)	0.6	1.2	4.8	0.0	-0.4	1.3	0.7	-0.3	-2.2
Ulcerative Colitis (UC)	0.6	1.1	2.5	0.7	-0.6	1.4	-0.2	-1.1	-1.6
Allergy or Eczema	0.6	1.5	3.9	1.6	1.1	2.0	0.7	0.6	0.3
Sensitivity / hurt feelings	0.6	1.0	2.9	-0.1	-0.3	1.0	0.7	1.7	-1.3
Pack years adult smoking proportion	0.6	0.9	2.6	1.1	0.4	1.6	0.8	0.9	-0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.4	0.7	0.3	1.1	0.3	1.6	-0.3
Allergy	0.6	1.3	3.4	-1.5	-1.2	-1.8	-0.7	-0.5	-0.3
Alcohol intake versus 10 years previously	0.6	0.9	1.8	0.9	0.4	1.3	0.9	0.9	-0.9
Falls in the last year	0.6	0.8	1.3	-0.1	0.6	1.2	1.1	0.8	-1.1
Happiness	0.6	0.8	2.1	0.7	-0.7	1.5	-0.3	0.1	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.1	4.3	-2.0	-0.4	-1.3	-0.5	-2.1	1.3
Medication: Paracetamol	0.6	1.0	1.6	-1.3	-0.9	-0.9	-1.0	-1.2	0.4
Headache pain in last month	0.6	1.1	2.5	-1.1	-1.2	-0.4	-0.9	-0.4	-1.6
Forced vital capacity (FVC), Best measure	0.6	2.3	5.1	-2.3	-0.5	-1.5	-0.5	-2.2	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	0.6	1.2	0.5	0.9	1.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.5	-0.3	-1.2	-1.1	-1.1	-0.3	-0.4
Number of self-reported non-cancer illnesses	0.6	1.0	2.3	0.4	-1.4	0.3	-1.4	0.3	-1.5
Medication: Atorvastatin	0.6	0.8	2.2	-1.3	-0.6	0.3	0.3	-0.5	-1.5
Unable to work because of sickness or disability	0.6	0.7	2.1	0.2	-0.0	1.5	0.6	0.6	-1.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	-0.4	-0.8	-0.7	-1.0	-1.2	-0.3
Bipolar Disorder (2018)	0.5	0.7	1.8	1.1	0.8	1.4	0.7	0.1	0.4
Hypothyroidism (self reported)	0.5	1.1	3.9	-0.7	-1.0	0.8	-0.5	-0.4	-2.0
Lung FVC	0.5	2.6	5.6	-1.9	0.6	-2.4	-0.2	-1.0	2.2
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.1	-0.6	-0.4	-1.1	-1.2	0.1
Severe depression (siblings)	0.5	0.6	1.0	-0.9	-0.8	0.7	-0.7	-0.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	0.3	1.0	0.3	0.7	1.1	0.6
Stomach or abdominal pain in last month	0.5	0.6	1.2	1.1	0.6	1.1	0.7	0.7	0.4
Medication: Atenolol	0.5	0.6	2.4	-0.7	-0.3	-1.5	-0.5	-0.3	0.5
High blood pressure (mother)	0.5	0.7	1.9	-0.4	1.0	0.6	1.4	-0.4	0.7
Alcohol usually taken with meals	0.5	0.8	2.5	0.7	1.0	0.3	0.6	0.5	1.6
Had menopause	0.5	0.6	1.9	0.6	0.8	1.4	0.6	-0.2	-0.4
Medication: Simvastatin	0.5	0.7	1.4	-0.3	-1.0	-0.9	-1.2	0.2	-0.8
Medication: Cholesterol lowering	0.5	0.7	2.9	-0.3	-0.7	-1.7	-0.9	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.4	-0.0	1.0	-0.2	0.3	0.0	1.6
Health satisfaction	0.5	0.6	1.3	0.7	-0.3	1.1	-0.0	0.8	-1.1
Emphysema/chronic bronchitis	0.5	0.5	2.3	1.5	0.3	0.1	-0.4	0.0	0.6
Friendships satisfaction	0.5	0.6	1.8	-0.2	-0.2	1.3	0.2	0.7	-1.1
Eye problems/disorders: Cataract	0.5	0.6	2.4	0.6	0.7	-0.2	0.4	-0.5	1.6
Smoking status: Current	0.5	0.8	2.3	1.5	0.5	0.5	-0.1	1.5	0.3
High cholesterol (Self-reported)	0.5	0.8	1.4	-1.2	-0.9	-0.8	-0.6	0.4	-1.2
Illnesses of father: High blood pressure	0.5	0.7	1.7	-0.7	-0.6	-1.1	-0.6	-1.3	0.2
Risk taking	0.5	0.7	2.9	0.2	0.7	0.8	0.7	1.7	0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.8	-0.4	0.8	0.9	1.3	-0.1	-0.5
Pain experienced in last month	0.5	0.9	3.1	-0.5	0.2	-1.4	-0.4	-0.2	1.8
Coronary Artery Disease (CAD)	0.4	0.5	1.6	-0.4	-0.0	-0.6	0.2	-0.8	-1.3
LDL Cholesterol	0.4	0.7	1.5	0.5	0.7	1.0	0.9	1.2	-0.3
Ulcerative Colitis	0.4	0.6	2.3	0.0	-0.1	1.5	0.1	-0.9	-0.7
Respiratory disease	0.4	0.9	2.7	-0.3	-0.9	-0.5	-1.6	-1.1	-0.6
Number of treatments/medications taken	0.4	0.7	1.9	-0.8	-1.0	-0.7	-1.4	0.1	-0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	-0.3	-0.6	1.0	0.2	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	0.5	0.4	0.6	1.3	0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.9	-1.1	-1.1	-1.4	-1.1	-0.6	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.4	1.1	0.6	0.7	1.2	0.7	-0.4
Had other major operations	0.4	0.5	1.7	-1.3	-0.4	-0.9	-0.5	0.0	-0.5
Forced vital capacity (FVC)	0.4	1.4	3.3	-1.8	-0.7	-1.4	-0.3	-1.5	0.6
Pain all over the body in last month	0.4	0.5	0.9	-0.0	0.2	1.0	0.6	1.0	-0.7
Fluid intelligence score	0.4	0.9	1.8	-1.2	0.7	-0.6	1.0	0.5	1.3
Worrier / anxious feelings	0.4	0.7	3.1	0.2	-0.8	0.5	-0.2	0.1	-1.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	-0.8	-0.3	-1.6	-0.7	-0.3	1.1
Asthma	0.4	0.8	1.3	-0.6	-0.9	0.2	-1.1	-1.1	-1.0
Glaucoma (self-reported)	0.4	0.5	1.1	-0.1	0.5	0.6	0.7	0.9	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	1.2	-0.0	1.1	-0.2	-0.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	1.2	0.5	0.2	0.7	0.2	0.7
Pulse rate, automated reading	0.4	1.1	4.1	-0.4	-0.7	-2.0	-1.1	0.5	0.8
Chest pain or discomfort	0.4	0.6	2.1	-0.5	-0.1	0.9	0.4	0.3	-1.4
Medication: Aspirin	0.4	0.5	1.1	0.2	0.5	-0.9	0.2	1.0	0.9
Supplements: Vitamin C	0.4	0.5	1.2	-1.1	-0.4	-0.6	-0.4	0.4	-0.8
Mood swings	0.4	0.7	3.0	-0.2	-0.9	0.4	-0.2	0.1	-1.7
Breast cancer (self-reported)	0.4	0.5	0.7	-0.7	0.8	0.8	0.7	-0.8	-0.3
Average weekly champagne plus white wine intake	0.4	0.6	1.7	0.8	0.8	-0.1	0.6	-0.5	1.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.2	-0.7	-0.5	-0.9	-0.9	0.4
Myopia	0.4	0.5	1.4	-0.5	-0.9	-1.2	-0.6	-0.6	0.1
Heart disease (siblings)	0.4	0.5	0.8	0.7	0.9	0.7	0.9	0.4	0.6
Alzheimer’s Disease (in father)	0.3	0.4	0.8	0.4	0.7	0.0	0.9	-0.5	0.7
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	-0.5	0.6	-0.3	0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	-0.5	0.3	-0.6	1.0	0.4	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.1	0.5	0.1	0.4	-0.2	1.1	-0.7
Supplements: Glucosamine	0.3	0.3	0.7	-0.5	-0.2	-0.7	-0.9	-0.3	0.7
Medication: Levothyroxine sodium	0.3	0.6	1.3	-1.1	-0.8	-0.5	-0.5	-0.4	-0.9
Sitting height	0.3	2.3	4.3	1.9	1.4	0.8	1.5	-1.1	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.8	-0.8	-0.4	-1.3	-0.9	-0.7	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.3	-1.5	-0.6	-1.1	-0.2	-1.4	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.8	0.5	0.7	0.4	0.1	1.3	1.2
Pulse wave reflection index	0.3	0.4	0.7	0.2	-0.6	-0.8	-0.6	-0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	0.0	0.3	1.2	0.8	0.6	-0.9
Qualifications: College or University degree	0.3	0.9	1.5	-1.2	-0.4	-0.9	-1.2	-0.7	1.1
Medication: Blood pressure	0.3	0.6	1.4	-0.1	-1.0	-0.5	-1.2	-0.0	-0.9
Comparative height size at age 10	0.3	1.4	2.7	1.6	1.1	1.6	1.1	-0.8	0.5
Leg pain on walking	0.3	0.4	1.6	-0.4	-0.1	0.5	0.0	-1.3	-0.2
Ever had bowel cancer screening	0.3	0.3	0.8	-0.4	-0.9	-0.6	-0.8	-0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.2	0.2	-0.8	0.1	0.9	0.6
Medication: Aspirin	0.3	0.4	0.9	-0.0	0.5	-0.8	0.2	0.8	1.0
Schizophrenia vs Biploar Disorder	0.2	0.2	1.1	0.3	0.1	0.2	0.1	1.1	-0.3
Waist Hip Ratio (WHR)	0.2	0.7	1.5	-0.1	-1.2	-0.5	-0.9	0.3	-1.2
Average weekly spirits intake	0.2	0.2	0.5	0.3	0.7	0.1	0.7	0.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	-0.1	0.3	-0.4	-0.2	-0.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.3	0.8	0.2	0.3	0.5	0.8
Mouth/teeth dental problems: Dentures	0.2	0.4	0.8	0.1	-0.7	0.5	-0.6	-0.8	-0.9
Medication: Lansoprazole	0.2	0.3	0.8	0.2	-0.4	0.5	-0.6	-0.9	-0.0
Prospective memory result	0.2	0.2	0.8	-0.5	-0.1	-0.3	-0.0	0.9	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.7	0.1	-0.6	-0.3	0.2	0.3
Length of working week for main job	0.2	0.2	0.4	-0.6	0.5	0.3	0.2	0.3	0.5
Birth weight	0.2	0.4	1.6	0.9	0.1	0.3	0.0	-1.3	0.2
High blood pressure (siblings)	0.2	0.3	0.5	-0.4	0.6	0.5	0.7	0.5	-0.2
Pulse wave peak to peak time	0.2	0.3	0.9	-1.0	-0.2	0.6	0.2	-0.4	-0.3
Qualifications: nursing, teaching	0.2	0.3	1.1	0.2	0.6	0.2	0.1	0.6	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.2	0.9	0.1	0.3	0.1	1.1	-0.2
Asthma (self-reported)	0.2	0.4	1.0	-0.1	-0.6	0.3	-0.8	-1.0	-0.7
Miserableness	0.2	0.4	1.0	0.6	-0.2	0.2	1.0	-0.2	-1.0
Ever taken oral contraceptive pill	0.2	0.2	0.9	0.2	0.4	-0.1	0.1	-0.2	1.0
Financial situation satisfaction	0.2	0.3	0.9	0.3	-0.3	0.7	-0.0	0.4	-0.9
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.1	0.7	-0.2	0.3	-0.2	0.9
Ever smoked	0.2	0.3	1.2	0.4	-0.2	0.4	-0.0	0.5	-1.1
Number of operations (self-reported)	0.2	0.4	0.9	-0.2	0.6	-0.2	0.4	-0.9	0.8
Blood White Count	0.1	0.7	1.6	0.1	-0.9	-1.1	-0.6	0.4	-1.3
Height	0.1	1.1	5.8	0.4	-0.4	0.0	-0.4	-2.4	0.4
Smoking Status	0.1	0.2	1.0	1.0	0.2	0.6	-0.3	0.1	-0.2
Hair Pigment	0.1	1.7	6.7	-0.2	-0.2	1.7	0.8	0.1	-2.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.5	0.0	0.5	0.1	0.3	-0.4
Diabetes (mother)	0.1	0.2	0.7	0.5	-0.2	0.0	-0.4	0.8	-0.0
Taking other prescription medications	0.1	0.1	0.1	-0.1	-0.4	-0.2	-0.4	-0.3	-0.3
Past tobacco smoking	0.1	0.2	0.4	-0.5	-0.2	-0.3	-0.4	-0.7	0.6
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	0.1	0.6	-0.1	0.7	0.1	0.5
Number of live births	0.1	0.1	0.3	0.4	0.3	0.1	-0.0	-0.4	0.5
Noisy workplace	0.1	0.2	0.3	0.5	-0.4	0.3	-0.0	-0.5	-0.5
Illnesses of mother	0.1	0.1	0.1	0.4	0.2	-0.2	-0.1	-0.3	0.4
Standing height	0.1	1.2	6.5	-0.4	-0.2	-0.2	0.3	-2.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	0.2	-0.3	0.2	-0.2	0.3	-0.8
Gout (self-reported)	0.1	0.2	0.4	0.6	0.1	0.4	-0.1	0.6	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.3	0.1	-0.7	-0.1	0.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.2	0.4	-0.5
Number of children fathered	0.1	0.1	0.3	0.1	0.5	0.4	0.3	0.2	-0.3
Had major operations	0.1	0.1	0.4	0.3	0.2	0.3	0.1	-0.6	0.6
Knee pain experienced in last month	0.1	0.2	0.3	0.5	0.4	0.6	0.2	-0.0	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.0	-0.4	-0.3	-0.6	0.5	-0.4
Mother’s age at death	0.1	0.1	0.3	-0.6	0.0	0.2	0.2	0.1	0.3
Medication: Paracetamol	0.1	0.2	0.5	-0.7	-0.5	-0.2	-0.4	-0.4	0.4
Average weekly beer plus cider intake	0.1	0.2	0.7	0.2	0.3	-0.8	-0.4	-0.0	0.6
Lung FEV1/FVC ratio	0.0	0.2	0.4	-0.5	-0.6	-0.1	-0.4	-0.6	-0.4
Tanning	0.0	0.6	1.3	-0.4	0.3	1.1	0.6	0.6	-1.1
Heart attack	0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.2	-0.3	0.2
Smoking status: Previous	0.0	0.1	0.1	0.3	0.1	0.0	0.4	0.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.2	-0.1	-0.0	-0.1	-0.0	-0.0

Hub : Genes

TP53BP1

Models

Trait associations