TWAS hub - TPCN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.048	0.0192	0.00077	0.021	0.026	0.019	0.027	0.014	0.00030	0.00008	0.00056	6e-05	0.0026
2	TCGA	Cervical Squamous Cell Carcinoma	0.101	0.0690	0.00550	0.069	0.007	0.007	NA	0.037	0.00027	0.13000	0.13000	NA	0.0065

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hypothyroidism/myxoedema (self-reported)	7.5	14.6	21.8	4.7	-2.7
Hypothyroidism (self reported)	7.2	16.5	24.9	5.0	-2.8
Leg pain on walking	5.8	7.3	8.8	2.4	-3.0
Medication: Levothyroxine sodium	5.6	9.4	17.1	4.1	-1.3
Ever used hormone-replacement therapy (HRT)	4.3	5.5	10.7	0.4	-3.3
Alzheimer’s Disease (in mother)	3.9	4.6	8.2	2.9	-1.0
Time employed in main current job	3.8	4.4	8.6	-0.4	-2.9
Townsend deprivation index at recruitment	3.7	5.1	7.2	2.7	-1.7
Waist Hip Ratio (WHR)	3.6	16.4	31.5	5.6	-1.1
Serious illness, injury or assault to yourself	3.5	4.3	8.2	0.6	-2.9
Medication: Blood pressure	3.5	6.7	9.3	2.1	-3.0
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	4.6	-2.1	1.7
Chronic bronchitis/emphysema (father)	3.3	3.9	4.8	-2.2	1.7
Number of operations (self-reported)	3.2	4.8	6.3	1.8	-2.5
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	7.4	-2.7	0.6
Long-standing illness, disability or infirmity	3.1	4.7	4.8	2.2	-2.1
Exposure to tobacco smoke outside home	2.9	3.9	7.3	2.7	-0.7
Health satisfaction	2.9	3.8	7.3	0.5	-2.7
Medication: Omeprazole	2.8	3.4	4.6	1.5	-2.1
Major Depression (MDD)	2.7	3.3	5.8	-0.9	2.4
Current tobacco smoking	2.6	4.3	5.7	-2.4	-1.7
Comparative body size at age 10	2.6	7.3	12.6	1.4	-3.5
High blood pressure	2.5	6.9	13.2	0.8	-3.6
Had other major operations	2.5	3.0	4.4	2.1	-1.3
Crohns Disease (2012)	2.4	3.8	6.4	2.5	-1.1
Multivitamins +/- minerals	2.4	3.1	5.1	-2.3	-1.0
Smoking status: Current	2.4	3.7	4.9	-2.2	-1.6
Medication: Ramipril	2.3	3.0	5.8	-0.4	-2.4
Vascular/heart problems diagnosed by doctor	2.3	6.2	11.7	-0.8	3.4
Had major operations	2.2	2.6	5.1	0.2	-2.2
Age started oral contraceptive pill	2.2	2.7	2.9	1.7	-1.6
Taking other prescription medications	2.1	3.2	5.8	0.8	-2.4
Stomach or abdominal pain in last month	2.1	2.6	2.9	1.7	-1.5
Depression (self-reported)	2.1	2.5	4.4	-2.1	0.8
Prospective memory result	2.1	2.5	4.5	0.7	-2.1
Medication: Ibuprofen	2.1	2.5	5.0	-2.2	0.2
Chest pain or discomfort	2.1	3.0	5.2	0.9	-2.3
Medication: Atorvastatin	2.1	2.6	4.5	-2.1	0.8
Pack years of smoking	2.1	3.2	5.1	1.1	-2.3
Body Mass Index (BMI) (2010)	2.0	2.7	3.3	1.8	-1.4
Medication: Allopurinol	2.0	2.6	3.3	1.8	-1.4
Hypertension (Self-reported)	2.0	5.6	10.3	0.9	-3.2
Average weekly spirits intake	1.9	2.3	4.2	-0.7	-2.0
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	2.5	-1.6	1.6
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	3.6	1.2	-1.9
Number of treatments/medications taken	1.8	3.2	6.2	0.4	-2.5
Medication for hormone replacement therapy	1.8	2.0	3.3	0.8	-1.8
Pack years adult smoking proportion	1.8	2.8	4.8	0.9	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	3.0	1.6	-1.7
Overall health rating	1.8	4.0	6.9	1.0	-2.6
Medication: Seretide 50 evohaler	1.7	1.9	3.4	-0.7	-1.8
Medication for cholesterol	1.7	2.5	2.9	-1.5	1.7
Average weekly beer plus cider intake	1.7	2.5	4.2	-2.0	-0.8
Commuting to job workplace: Cycle	1.7	2.1	2.8	1.7	1.2
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	3.5	0.8	-1.9
Pulse wave reflection index	1.6	2.0	2.5	-1.6	1.2
Suffer from ‘nerves’	1.6	2.5	4.6	-2.1	-0.6
Mother’s age at death	1.6	2.0	3.7	-0.5	1.9
Blood Platelet Count	1.5	16.9	32.4	5.7	-1.2
Lung FEV1/FVC ratio	1.5	7.5	8.7	2.5	-3.0
Pulse rate	1.5	2.5	4.2	0.9	-2.0
Blood clot in the leg (DVT)	1.5	1.9	2.9	1.0	-1.7
Diabetes diagnosed by doctor	1.5	2.5	3.5	-1.9	1.2
Alzheimer’s Disease (in father)	1.4	1.5	2.0	-1.1	1.4
Primary Biliary Cirrhosis	1.4	2.0	4.0	2.0	-0.0
Pain all over the body in last month	1.4	1.5	2.8	-0.5	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.2	1.8	-0.2
Breastfed as a baby	1.4	1.7	2.0	-1.4	1.2
Worry too long after embarrassment	1.4	2.4	2.6	-1.5	1.6
Ever had bowel cancer screening	1.4	1.7	3.0	0.6	-1.7
Eye problems/disorders: Glaucoma	1.4	1.7	2.6	-1.6	0.9
HDL Cholesterol	1.3	2.2	2.4	1.6	1.4
Cardiovascular Disease	1.3	4.4	7.1	1.3	-2.7
Sensitivity / hurt feelings	1.3	2.2	3.1	-1.8	1.2
Had menopause	1.3	1.7	3.3	0.2	-1.8
Pulse rate, automated reading	1.3	4.2	8.4	-0.0	-2.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.4	1.5	0.7
Unable to work because of sickness or disability	1.3	1.7	3.4	0.3	-1.8
Alcohol drinker status: Previous	1.3	1.5	2.9	1.7	-0.2
Supplements: Zinc	1.2	1.3	2.6	-0.0	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.2	0.9	-1.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	1.7	1.0	-1.3
Number of incorrect matches in round	1.2	2.0	4.0	2.0	0.1
Falls in the last year	1.2	1.6	2.7	1.6	-0.7
Noisy workplace	1.2	1.4	2.4	1.6	-0.7
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.6	1.2	-1.1
Medication: Bendroflumethiazide	1.2	1.9	3.7	0.2	-1.9
Ever depressed for a whole week	1.2	1.5	3.0	-0.2	-1.7
Intelligence (Savage-Jansen 2018)	1.1	3.3	6.4	-0.5	2.5
Hand grip strength (right)	1.1	2.9	5.7	-2.4	0.2
Hearing difficulty/problems with background noise	1.1	1.8	2.9	0.8	-1.7
Arm fat percentage (right)	1.1	4.2	6.4	-1.4	-2.5
Alcohol intake versus 10 years previously	1.1	1.7	2.4	1.6	1.0
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	2.0	1.3	1.4
Glaucoma (self-reported)	1.1	1.3	1.4	-1.1	1.2
High blood pressure (siblings)	1.1	1.6	2.9	1.7	0.5
Eye problems/disorders: None of the above	1.1	1.2	2.3	1.5	0.4
Basal cell carcinoma (self-reported)	1.1	1.3	2.1	0.7	1.4
Blood Eosinophil Count	1.0	7.7	12.9	3.6	-1.6
Chronotype (morning person)	1.0	2.3	3.9	-0.8	-2.0
Supplements: Glucosamine	1.0	1.3	2.5	0.1	-1.6
Waist circumference	1.0	3.6	6.6	0.8	-2.6
Fluid intelligence score	1.0	2.1	2.2	-1.5	1.4
Illnesses of siblings	1.0	1.4	1.8	-1.4	0.9
Hair/balding pattern: Pattern 3	1.0	1.5	1.8	-1.1	1.3
Number of live births	1.0	1.5	2.2	1.5	0.8
Illnesses of mother	1.0	1.3	2.4	-1.5	-0.3
Wheeze or whistling in the chest in last year	1.0	1.7	3.3	0.4	-1.8
Migraine (self-reported)	1.0	1.3	2.1	1.4	-0.7
Arm fat percentage (left)	1.0	4.0	5.4	-1.6	-2.3
Osteoarthritis (self-reported)	1.0	1.3	1.3	1.1	-1.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	1.7	1.3	0.8
Medication: Lisinopril	1.0	1.3	2.2	-0.6	-1.5
Blood White Count	0.9	6.5	10.7	3.3	-1.5
Relative age of first facial hair	0.9	1.8	3.1	-1.8	0.7
Vitamin and mineral supplements	0.9	1.2	2.4	1.6	-0.1
Relative age voice broke	0.9	1.3	2.4	-1.6	0.5
Diabetes (self-reported)	0.9	1.4	1.5	-1.2	1.2
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	-1.4	-0.4
Arm fat mass (right)	0.9	3.6	5.9	-1.2	-2.4
Tense / ‘highly strung’	0.9	1.5	2.4	1.6	-0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.6	-0.7	1.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.5	0.9	-1.2
Birth weight	0.9	2.0	3.1	-1.8	0.9
Pulse wave peak to peak time	0.9	1.0	1.8	1.4	0.5
Shortness of breath walking on level ground	0.9	1.1	2.1	0.3	-1.4
Angina (self-reported)	0.9	1.1	2.2	1.5	-0.0
Mean time to correctly identify matches	0.9	1.7	1.9	1.2	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.1	-1.4	0.1
Whole body fat mass	0.9	3.6	6.0	-1.1	-2.4
Family relationship satisfaction	0.9	1.2	1.9	-0.7	1.4
Back pain experienced in last month	0.9	1.3	2.2	-0.6	1.5
Arm fat mass (left)	0.9	3.6	6.4	-0.9	-2.5
Commuting to job workplace: Public transport	0.9	1.1	2.2	-1.5	-0.0
Trunk fat percentage	0.8	3.1	4.9	-1.1	-2.2
Age when periods started (menarche)	0.8	2.0	3.0	-1.0	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	2.8	-0.9	-1.7
Body mass index (BMI)	0.8	3.4	6.4	-0.6	-2.5
Trunk fat mass	0.8	3.6	5.8	-1.2	-2.4
Alcohol usually taken with meals	0.8	1.3	1.9	-0.8	1.4
Body fat percentage	0.8	3.2	4.9	-1.2	-2.2
Medication: Blood pressure	0.8	1.4	2.5	-0.6	-1.6
Leg fat mass (right)	0.8	3.3	6.3	-0.6	-2.5
Smoking status: Previous	0.8	1.1	2.3	1.5	-0.2
Friendships satisfaction	0.8	1.0	2.0	-1.4	0.1
Medication: Gliclazide	0.8	0.9	1.3	-1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	1.7	1.3	-1.3
Guilty feelings	0.8	1.1	1.5	1.2	0.9
Illnesses of father: High blood pressure	0.8	1.0	1.7	1.3	-0.5
HbA1C	0.7	0.8	1.1	1.1	0.7
LDL Cholesterol	0.7	1.1	2.1	-1.4	0.1
Lupus	0.7	1.0	1.4	1.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.7	0.2	-1.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.5	-0.5	-1.2
Weight	0.7	3.6	6.6	-0.8	-2.6
Hip circumference	0.7	2.9	4.4	-1.2	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	3.1	1.1	-1.8
Leg fat percentage (right)	0.7	2.4	4.6	-0.5	-2.1
Number of full brothers	0.7	0.8	1.6	-1.3	0.2
Age at first live birth	0.7	1.3	2.5	-1.6	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.6	0.3	1.2
Loneliness, isolation	0.7	1.0	1.4	-1.2	0.7
Number of self-reported non-cancer illnesses	0.7	1.1	1.3	1.0	-1.1
Wears glasses or contact lenses	0.7	0.8	0.8	-0.9	-0.9
Financial situation satisfaction	0.7	0.9	1.8	-0.2	-1.3
Cholesterol lowering medication	0.7	1.0	1.7	1.3	0.5
Leg fat mass (left)	0.7	2.9	5.5	-0.6	-2.3
Ovarian Cancer	0.6	0.9	1.5	-0.5	-1.2
Neuroticism (2016)	0.6	0.8	1.5	-1.2	0.4
Ulcerative Colitis	0.6	0.9	1.1	0.8	-1.1
Angina	0.6	0.8	1.4	1.2	-0.3
Medication: Co-codamol	0.6	0.6	1.2	1.1	0.3
High blood pressure (mother)	0.6	0.8	1.3	1.2	0.6
Past tobacco smoking	0.6	1.1	1.6	-1.3	0.8
Mouth/teeth dental problems	0.6	0.9	1.8	-0.2	1.4
Medication: Simvastatin	0.6	0.8	1.4	1.2	0.5
Father’s age at death	0.6	0.8	1.2	0.6	-1.1
Gout (self-reported)	0.6	0.8	1.3	1.1	-0.5
Alcohol intake frequency.	0.6	1.4	1.8	1.4	1.0
Comparative height size at age 10	0.6	3.2	5.9	0.7	-2.4
Knee pain experienced in last month	0.6	0.9	1.7	1.3	-0.2
Mood swings	0.6	1.0	1.6	0.7	-1.3
Commuting to job workplace: Walk	0.6	0.7	1.1	-1.0	0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	-1.1	0.5
Leg fat percentage (left)	0.6	2.1	3.8	-0.7	-1.9
Arm predicted mass (left)	0.6	3.2	6.3	0.4	-2.5
Neuroticism (Nagel 2018)	0.5	1.1	1.8	-0.7	1.3
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.2	-0.5	1.5
Triglycerides	0.5	0.8	0.9	-0.9	-0.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.9	0.6	0.9
BMI	0.5	2.7	3.8	-1.2	-2.0
Type 2 Diabetes (T2D) (2018)	0.5	0.8	1.6	-1.2	-0.4
Hand grip strength (left)	0.5	1.3	2.6	-1.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	0.6	-1.0
Diabetes (father)	0.5	0.6	1.1	1.1	0.3
Severe depression (siblings)	0.5	0.5	1.0	1.0	-0.2
Leg fat-free mass (left)	0.5	2.4	4.8	-0.2	-2.2
Medication: Atenolol	0.5	0.6	1.0	-0.3	1.0
Leg predicted mass (left)	0.5	2.5	4.8	-0.2	-2.2
Qualifications: None of the above	0.5	1.1	2.0	1.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.5	0.0	-1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.2	1.0	-1.5
Mouth/teeth dental problems: Dentures	0.5	0.8	1.0	-0.7	-1.0
Lung cancer (father)	0.5	0.6	1.3	-1.1	-0.1
Birth weight of first child	0.5	0.9	1.3	-0.7	1.1
Number of children fathered	0.5	0.5	1.0	-0.1	-1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.5	0.9	1.0	0.4
Heart disease (mother)	0.5	0.6	1.1	-0.4	1.1
Medication: Aspirin	0.5	0.6	1.0	-0.5	-1.0
Medication: Aspirin	0.5	0.7	1.3	0.3	-1.1
Whole body water mass	0.5	2.6	5.2	-0.1	-2.3
High cholesterol (Self-reported)	0.5	0.8	1.1	1.0	0.7
Basal metabolic rate	0.5	2.7	5.4	-0.2	-2.3
Arm fat-free mass (left)	0.5	2.7	5.3	0.4	-2.3
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	1.1	-0.0
Fractured/broken bones in last 5 years	0.5	0.6	1.2	0.1	-1.1
Pain experienced in last month	0.5	0.9	1.4	0.6	-1.2
Heart disease (siblings)	0.5	0.6	0.7	0.7	-0.8
Reaction Time	0.4	0.8	1.2	0.6	-1.1
Fasting Glucose	0.4	0.5	0.9	-0.9	0.2
Smoking Status	0.4	1.0	1.9	0.3	-1.4
Systolic blood pressure, automated reading	0.4	1.1	1.8	1.3	-0.6
Trunk fat-free mass	0.4	2.2	4.4	0.1	-2.1
Medication: Cholesterol lowering	0.4	0.6	0.9	-1.0	0.5
Impedance of arm (left)	0.4	1.9	2.2	-1.5	1.3
Trunk predicted mass	0.4	2.3	4.5	0.1	-2.1
Medication: Amlodipine	0.4	0.6	1.2	-0.0	-1.1
Forced vital capacity (FVC), Best measure	0.4	1.4	2.1	0.8	-1.4
Illnesses of siblings: Diabetes	0.4	0.5	0.7	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	-0.6	1.1
Whole body fat-free mass	0.4	2.4	4.8	0.0	-2.2
Leg fat-free mass (right)	0.4	2.0	4.0	-0.2	-2.0
Average weekly red wine intake	0.4	0.5	0.6	-0.7	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.8	-0.4	-0.9
Leg predicted mass (right)	0.4	2.0	4.0	-0.1	-2.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.7	0.8	0.6
Alcohol drinker status: Never	0.4	0.4	0.9	0.1	-0.9
Ever smoked	0.4	0.7	1.0	0.6	-1.0
Depression (Nagel 2018)	0.3	0.4	0.7	0.8	-0.3
Crohns Disease (2017)	0.3	0.7	0.8	0.8	0.9
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	0.0
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.8	0.2
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	0.0
Allergy or Eczema	0.3	0.7	0.9	0.9	-0.8
Lung FVC	0.3	1.6	1.7	1.3	-1.2
Maternal smoking around birth	0.3	0.4	0.6	-0.4	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.9	0.2
Neuroticism score	0.3	0.5	1.0	-1.0	-0.1
Impedance of arm (right)	0.3	1.5	1.5	-1.2	1.2
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	1.2	-0.5
Loud music exposure frequency	0.3	0.3	0.4	0.5	0.7
Medication: Paracetamol	0.3	0.4	0.8	0.3	0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	-0.1
Arm fat-free mass (right)	0.3	1.6	3.1	-0.1	-1.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	1.0	-0.0
Arm predicted mass (right)	0.3	1.6	3.1	0.2	-1.8
Number of full sisters	0.3	0.4	0.7	-0.8	0.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.9	-0.2
Eye problems/disorders: Cataract	0.3	0.3	0.5	0.7	-0.3
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.7	0.4
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.0	-0.8
Irritability	0.3	0.5	0.7	0.6	-0.8
Risk taking	0.3	0.4	0.9	0.9	0.1
Diastolic blood pressure, automated reading	0.3	1.0	1.9	0.2	-1.4
Impedance of whole body	0.3	1.6	2.9	-0.6	1.7
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.2	-0.9
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	-0.3	0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.7	0.4
Age at First Birth	0.2	0.3	0.5	-0.0	-0.7
Schizophrenia (2014)	0.2	0.4	0.7	-0.2	0.8
Blood Red Count	0.2	2.0	3.9	0.4	-2.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	0.6	-0.5
Medication: Metformin	0.2	0.2	0.3	-0.5	0.4
Impedance of leg (right)	0.2	0.9	1.7	-0.0	1.3
Average weekly fortified wine intake	0.2	0.3	0.4	-0.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.9	0.4	-1.0
Impedance of leg (left)	0.2	1.1	2.2	-0.2	1.5
Nervous feelings	0.2	0.4	0.6	-0.4	0.8
Forced vital capacity (FVC)	0.2	0.9	1.0	0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.5	-0.7	-0.6
Allergy	0.2	0.4	0.5	-0.7	0.6
Happiness	0.2	0.2	0.5	-0.7	-0.2
Qualifications: College or University degree	0.2	0.7	1.0	1.0	-0.6
Emphysema/chronic bronchitis	0.2	0.3	0.3	0.4	0.6
Neck or shoulder pain in last month	0.2	0.2	0.3	0.4	0.5
Age at last live birth	0.2	0.4	0.6	-0.8	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.0	0.7
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.5	-0.7
Mineral and other dietary supplements	0.2	0.2	0.4	-0.6	-0.3
Miserableness	0.2	0.3	0.5	-0.4	0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	0.4	-0.5
Medication: Paracetamol	0.2	0.3	0.5	0.3	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.4	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.3	0.5
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.5	0.3
Heel T-Score	0.1	1.1	1.5	1.2	-0.9
Neuroticism	0.1	0.3	0.6	-0.2	0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.4	-0.3
Diabetes (mother)	0.1	0.1	0.2	0.4	0.1
Fed-up feelings	0.1	0.2	0.3	0.1	0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.2	-0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.7	-0.1
Financial difficulties in last 2 years	0.1	0.2	0.3	-0.1	-0.6
Worrier / anxious feelings	0.1	0.1	0.1	0.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.5	0.2
Asthma	0.1	0.2	0.3	0.2	0.6
Peak expiratory flow (PEF)	0.1	0.1	0.2	-0.5	-0.2
Headache pain in last month	0.1	0.2	0.2	0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.2	0.4	0.4
Supplements: Vitamin C	0.1	0.1	0.1	-0.0	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.3	0.4
Asthma (self-reported)	0.1	0.2	0.3	0.6	0.2
Hearing aid user	0.1	0.1	0.1	-0.3	0.2
Myopia	0.1	0.1	0.1	-0.4	-0.1
Supplements: Calcium	0.1	0.1	0.2	-0.4	-0.2
Schizophrenia (2018)	0.0	0.1	0.1	-0.4	-0.2
Worry (Nagel 2018)	0.0	0.1	0.2	0.0	0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.1	0.1	-0.3	0.1
Height	0.0	0.8	1.1	-0.7	-1.1
Systolic Blood Pressure	0.0	0.0	0.1	0.1	-0.2
Respiratory disease	0.0	0.0	0.0	0.1	0.2
Hair Pigment	0.0	0.8	1.1	-1.1	0.7
Tanning	0.0	0.5	1.0	1.0	0.1
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.0	0.2
Sitting height	0.0	0.0	0.0	-0.1	0.0
Heart attack	0.0	0.0	0.1	-0.3	-0.0
Medication: Lansoprazole	0.0	0.0	0.0	0.2	0.0
Standing height	0.0	0.3	0.4	-0.6	-0.5
Length of working week for main job	0.0	0.0	0.0	0.1	-0.0
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.0	-0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	-0.0	-0.1
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	0.1
Osteoporosis (self-reported)	0.0	0.1	0.1	-0.2	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	0.0

Hub : Genes

TPCN1

Models

Trait associations