Hub : Genes

TPP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.101	0.0260	2.2e-07	0.100	0.048	0.084	0.067	0.089	3.7e-12	1.7e-06	1.8e-10	1.4e-08	6.1e-11
2	GTEx	Testis	0.190	0.0740	6.8e-03	0.006	NA	-0.005	NA	-0.004	1.7e-01	NA	6.0e-01	NA	5.6e-01
3	YFS	Blood	0.044	0.0129	4.7e-07	0.042	0.026	0.041	0.038	0.040	1.0e-13	4.9e-09	2.6e-13	1.3e-12	3.6e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.7	2.7	5.8	2.4	-0.5	-1.4
Bipolar Disorder or Schizophrenia	1.9	4.6	9.7	3.1	-1.0	-1.8
Depressed Affect (Nagel 2018)	1.8	3.7	6.6	2.6	-1.5	-1.5
Depression (Nagel 2018)	1.3	2.0	3.0	1.3	-1.7	-1.2
Intelligence (Savage-Jansen 2018)	0.8	2.4	4.3	-0.2	2.1	1.7
Neuroticism (Nagel 2018)	0.8	2.0	4.0	2.0	-0.8	-1.2
Schizophrenia (2018)	1.0	2.1	4.3	2.1	-0.9	-1.2
Schizophrenia vs Biploar Disorder	0.7	0.9	1.7	-1.3	0.4	0.9
Worry (Nagel 2018)	0.0	0.0	0.1	0.3	0.2	-0.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	0.8	0.4	-1.0
Alzheimer’s Disease (in father)	1.3	1.4	2.5	-0.4	1.6	1.3
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	0.3	1.1	-0.3
Crohns Disease (2017)	0.5	1.1	1.4	0.8	-1.2	-1.1
Irritable Bowel Disease (IBD)	0.1	0.1	0.2	-0.5	-0.4	-0.1
Ulcerative Colitis (UC)	0.3	0.6	1.0	-1.0	0.5	0.7
Major Depression (MDD)	1.7	2.1	3.2	1.3	-1.8	-1.2
Reaction Time	0.5	0.9	2.1	-0.7	-0.2	1.4
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.1	-0.5	1.8	1.6
Breast Cancer	0.2	0.4	0.8	-0.9	-0.5	-0.2
Ovarian Cancer	0.6	0.7	1.3	-0.4	-0.9	-1.2
Prostate Cancer	1.1	1.6	2.5	-0.5	1.6	1.4
Age at First Birth	0.1	0.2	0.3	0.2	0.6	-0.4
Bipolar Disorder (2011)	4.7	4.6	8.2	2.9	-1.1	-2.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.7	-0.0	-0.4
Coronary Artery Disease (CAD)	4.5	5.3	6.3	-2.0	2.5	2.4
Crohns Disease (2012)	0.1	0.1	0.4	-0.1	0.1	-0.6
Mean Putamen Volume	1.0	1.1	2.1	-0.0	-1.4	-1.1
Fasting Glucose	0.0	0.0	0.1	0.0	-0.2	0.2
HbA1C	5.3	5.9	7.6	-2.1	2.4	2.8
HDL Cholesterol	1.3	2.2	3.0	-1.3	1.3	1.7
LDL Cholesterol	0.0	0.0	0.0	0.1	0.1	0.1
Lupus	0.4	0.6	0.8	-0.9	0.7	0.6
Neuroticism (2016)	4.7	6.7	12.0	1.0	-3.5	-2.7
Primary Biliary Cirrhosis	1.6	2.3	3.6	0.8	-1.6	-1.9
Rheumatoid Arthritis	0.2	0.2	0.3	0.6	0.2	-0.5
Schizophrenia (2014)	1.4	3.0	6.2	2.5	-0.8	-1.5
Triglycerides	1.7	2.7	3.4	1.6	-1.5	-1.9
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.2	1.4	-0.1	-1.5
Ulcerative Colitis	0.2	0.3	0.5	-0.7	-0.6	-0.1
Blood Eosinophil Count	1.0	7.6	9.9	-2.4	3.1	2.6
Blood Platelet Count	0.5	5.4	11.0	-0.3	-3.3	-2.2
Blood Red Count	0.8	8.0	13.2	-3.6	2.2	2.5
Blood White Count	0.1	0.8	1.6	0.6	-0.6	-1.3
Heel T-Score	0.3	2.1	2.9	-1.7	1.3	1.3
BMI	0.8	4.7	5.2	2.3	-2.1	-2.1
Height	0.1	1.6	2.0	-1.4	1.2	1.1
Waist Hip Ratio (WHR)	1.1	4.8	7.2	2.0	-1.8	-2.7
Systolic Blood Pressure	0.4	2.2	4.5	-2.1	1.0	1.0
Smoking Status	2.5	6.0	7.2	2.7	-1.9	-2.7
Allergy or Eczema	1.1	3.0	3.7	-1.4	1.9	1.8
Cardiovascular Disease	0.9	3.0	4.9	1.0	-1.7	-2.2
Hypothyroidism (self reported)	0.1	0.2	0.5	0.7	0.4	0.1
Respiratory disease	0.8	1.8	3.5	0.8	1.9	1.2
Type 2 Diabetes (T2D) (2018)	1.2	2.2	2.5	1.5	-1.4	-1.6
Lung FEV1/FVC ratio	0.1	0.7	2.1	1.4	0.2	-0.3
Lung FVC	0.2	0.9	2.2	-1.5	0.7	0.2
Neuroticism	1.2	2.9	4.4	2.1	-1.3	-1.6
Chronotype (morning person)	1.1	2.6	3.3	-1.4	1.8	1.6
Hair Pigment	0.2	6.4	8.3	2.1	-2.6	-2.9
Tanning	0.1	0.9	1.6	0.6	-1.3	-0.8
Hand grip strength (left)	0.7	1.9	2.7	-1.5	1.7	0.9
Number of treatments/medications taken	0.5	0.9	2.5	1.6	0.1	-0.4
Average weekly spirits intake	0.3	0.4	1.0	1.0	-0.5	0.2
Sensitivity / hurt feelings	2.4	4.1	5.3	1.9	-1.9	-2.3
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.3	2.1	-1.6	-1.0
Hearing difficulty/problems: Yes	0.8	1.2	3.5	1.9	0.4	-0.3
Relative age of first facial hair	0.8	1.7	2.7	-1.6	0.4	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	1.0	0.4	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	-0.0	0.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	1.3	-0.4	-0.6
Systolic blood pressure, automated reading	0.3	0.8	1.5	-1.2	0.3	0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.4	0.3	-0.5
Angina	1.3	1.6	2.0	1.4	-1.2	-1.2
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.7	-0.2	0.7
Vitamin and mineral supplements	1.4	1.9	2.7	1.4	-1.7	-1.0
Supplements: Zinc	6.0	6.5	8.7	-3.0	2.5	2.2
Medication: Co-codamol	2.9	3.3	3.8	1.6	-1.9	-2.0
Medication: Metformin	0.2	0.3	0.4	0.3	-0.5	-0.6
Diabetes (father)	0.6	0.8	1.3	0.3	-1.2	-1.0
Diabetes (mother)	1.5	1.9	2.4	1.3	-1.5	-1.3
Severe depression (siblings)	0.2	0.3	0.6	-0.2	0.8	0.4
Pack years adult smoking proportion	0.1	0.1	0.2	-0.0	0.4	0.3
Impedance of leg (right)	0.9	4.4	5.8	-2.4	1.8	2.1
Leg fat-free mass (left)	0.1	0.5	0.9	0.9	-0.1	-0.9
Trunk fat percentage	0.9	3.5	5.0	2.2	-1.5	-1.8
Hand grip strength (right)	1.3	3.7	5.0	-2.2	1.7	1.7
Townsend deprivation index at recruitment	1.4	2.0	2.7	1.3	-1.6	-1.3
Current tobacco smoking	0.6	1.0	1.8	1.3	-0.6	-1.0
Average weekly fortified wine intake	0.2	0.3	0.5	0.7	-0.4	-0.4
Maternal smoking around birth	1.2	1.8	3.8	1.9	-0.8	-1.0
Fed-up feelings	1.7	3.1	6.9	2.6	-1.0	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	3.8	1.6	-2.0	-1.7
Relative age voice broke	0.1	0.2	0.5	-0.7	-0.2	0.1
Taking other prescription medications	1.9	2.9	6.3	2.5	-0.9	-1.3
Age when periods started (menarche)	0.2	0.5	1.0	-1.0	0.5	0.4
Bilateral oophorectomy (both ovaries removed)	3.3	3.8	5.0	1.6	-2.2	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	-0.4	-0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	0.2	1.3	0.9
Qualifications: CSEs or equivalent	1.4	1.8	3.4	-1.8	1.0	1.0
Serious illness, injury or assault to yourself	2.0	2.4	3.4	1.5	-1.2	-1.9
High blood pressure	0.7	2.0	3.4	1.0	-1.2	-1.8
Hayfever, allergic rhinitis or eczema	1.3	2.9	3.9	-1.2	2.0	1.8
Multivitamins +/- minerals	2.0	2.5	4.0	-1.5	2.0	1.1
Stomach or abdominal pain in last month	2.5	3.1	5.2	2.3	-1.3	-1.6
Supplements: Glucosamine	1.9	2.4	4.5	-0.7	2.1	1.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.5	-0.1	-0.6
Medication: Atenolol	1.5	1.9	2.3	1.1	-1.4	-1.5
Medication: Levothyroxine sodium	0.1	0.2	0.2	0.4	-0.5	-0.3
Sitting height	0.4	2.9	5.6	-2.4	1.3	1.3
Chronic bronchitis/emphysema (father)	2.3	2.7	6.1	2.5	-0.7	-1.2
High blood pressure (mother)	1.0	1.4	2.8	0.3	-1.2	-1.7
Body mass index (BMI)	1.3	5.7	8.8	3.0	-1.9	-2.2
Impedance of leg (left)	0.6	3.0	4.2	-2.0	1.2	1.8
Leg predicted mass (left)	0.1	0.5	0.8	0.8	-0.1	-0.9
Trunk fat mass	0.7	3.0	4.5	2.1	-1.2	-1.8
Waist circumference	1.2	4.4	6.7	2.6	-1.3	-2.2
Number of incorrect matches in round	0.3	0.4	0.7	-0.5	0.8	0.6
Past tobacco smoking	1.2	2.3	3.5	-1.9	1.2	1.4
Alcohol usually taken with meals	1.8	2.9	3.8	-1.9	1.9	1.2
Nervous feelings	0.2	0.4	1.0	1.0	0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.0	2.2	-0.9	-0.8
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.9	0.0	0.4
Hair/balding pattern: Pattern 2	0.9	1.2	2.8	-0.8	0.4	1.7
Had menopause	0.1	0.1	0.1	-0.2	-0.3	0.3
Had other major operations	0.3	0.4	0.9	0.9	0.4	-0.3
Forced vital capacity (FVC)	0.4	1.5	3.3	-1.8	0.9	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	-0.8	-0.3	0.1
Ever unenthusiastic/disinterested for a whole week	3.2	4.0	4.7	2.2	-1.8	-1.9
Qualifications: None of the above	2.2	4.7	5.8	1.9	-2.4	-2.2
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.6	-0.1	0.0
Mouth/teeth dental problems	0.2	0.4	0.5	-0.6	0.5	0.7
Heart attack	0.2	0.3	0.8	0.9	-0.2	-0.3
Allergy	0.9	2.0	2.9	0.9	-1.7	-1.5
Pain all over the body in last month	0.2	0.2	0.5	0.7	-0.3	-0.4
Diabetes (self-reported)	0.3	0.4	0.6	0.6	-0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.2	-0.7	1.7	1.8
Medication: Ramipril	0.1	0.1	0.2	0.5	-0.1	-0.4
Medication: Simvastatin	0.3	0.4	0.6	0.4	-0.7	-0.7
Fluid intelligence score	1.1	2.3	3.9	-0.2	1.8	2.0
Illnesses of siblings	0.5	0.7	1.2	-0.4	0.8	1.1
Neuroticism score	1.6	3.4	4.9	2.2	-1.5	-1.8
Weight	0.4	1.9	3.3	1.8	-0.9	-1.3
Impedance of arm (right)	0.1	0.4	0.6	-0.8	0.2	0.8
Arm fat percentage (right)	2.0	7.9	11.1	3.3	-2.4	-2.6
Trunk fat-free mass	0.0	0.2	0.3	0.5	0.3	-0.5
Hip circumference	0.4	1.5	3.5	1.9	-0.4	-0.9
Time employed in main current job	0.5	0.5	1.5	-1.2	-0.1	-0.4
Alcohol intake versus 10 years previously	3.4	5.1	6.6	2.6	-1.7	-2.4
Father’s age at death	0.1	0.1	0.4	-0.0	-0.1	0.6
Worrier / anxious feelings	0.7	1.4	1.8	1.3	-0.8	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.2	1.5	-0.3	0.2
Falls in the last year	0.1	0.2	0.5	0.7	0.2	0.1
Hair/balding pattern: Pattern 3	0.9	1.3	2.1	-0.9	1.5	1.1
Number of live births	0.9	1.3	2.0	1.4	-0.1	-1.4
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	2.8	-1.7	1.4	0.9
Pulse rate	0.2	0.3	0.4	-0.6	-0.5	-0.5
Happiness	0.0	0.0	0.1	0.1	0.3	0.0
Noisy workplace	0.1	0.1	0.4	-0.2	-0.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.4	0.1	1.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.6	0.8	0.2
Mouth/teeth dental problems: Dentures	0.7	1.3	1.5	1.2	-1.1	-1.0
Asthma	0.3	0.7	1.5	0.4	1.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.1	-0.5	1.0	0.8
Medication: Cholesterol lowering	0.6	1.0	2.0	-0.2	1.4	0.9
Depression (self-reported)	5.0	6.0	9.7	3.1	-2.0	-2.0
Medication: Lansoprazole	1.0	1.1	3.0	1.7	-0.5	-0.4
Prospective memory result	0.6	0.7	1.3	0.5	-0.8	-1.1
Lung cancer (father)	0.5	0.6	0.8	-0.9	0.9	0.5
Illnesses of mother	0.5	0.7	1.1	-0.9	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	3.8	-1.9	1.9	1.3
Pulse wave Arterial Stiffness index	0.5	0.6	0.9	0.2	-1.0	-1.0
Impedance of arm (left)	0.2	0.9	2.0	-1.4	0.2	0.7
Arm fat mass (right)	1.6	6.6	9.5	3.1	-2.1	-2.4
Trunk predicted mass	0.0	0.2	0.3	0.5	0.3	-0.6
Standing height	0.5	4.7	6.0	-2.4	2.2	1.8
Length of working week for main job	0.8	0.9	1.8	-1.3	0.8	-0.2
Exposure to tobacco smoke at home	5.0	5.6	8.4	1.9	-2.9	-2.2
Breastfed as a baby	2.2	2.7	4.8	1.5	-1.1	-2.2
Tense / ‘highly strung’	0.9	1.5	3.5	1.9	-0.6	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	4.2	2.1	-1.9	-1.7
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.5	-0.4	-0.7
Birth weight of first child	0.3	0.5	0.9	0.2	-0.7	-0.9
Peak expiratory flow (PEF)	1.6	3.6	4.9	-1.9	2.2	1.5
Pulse wave reflection index	0.1	0.1	0.2	-0.2	0.0	0.5
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.5	1.6	-0.2	0.1
Loud music exposure frequency	0.4	0.5	0.8	0.8	-0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.4	-0.4	1.1	1.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.9	-0.7	0.9	0.8
Blood clot in the leg (DVT)	0.6	0.8	1.1	1.0	-0.6	-1.0
Medication: Paracetamol	2.4	4.0	6.8	2.6	-1.3	-1.8
Headache pain in last month	0.1	0.1	0.3	0.5	-0.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	0.3	-1.1	-0.9
Glaucoma (self-reported)	0.4	0.4	1.2	-1.1	0.2	0.0
Gout (self-reported)	0.3	0.4	0.9	1.0	-0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.2	-0.2	-0.1
Medication: Amlodipine	0.0	0.0	0.1	-0.3	-0.1	0.2
Medication: Ventolin 100micrograms inhaler	1.5	2.0	2.6	1.6	-1.3	-1.2
Birth weight	0.4	0.8	1.5	0.8	-0.6	-1.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.1	1.2	0.8
High blood pressure (siblings)	0.1	0.2	0.4	-0.1	-0.6	-0.3
Forced vital capacity (FVC), Best measure	1.0	3.5	5.2	-2.3	1.8	1.4
Body fat percentage	1.0	4.0	6.0	2.4	-1.5	-1.9
Leg fat percentage (right)	0.9	3.1	5.9	2.4	-1.1	-1.5
Arm fat-free mass (right)	0.1	0.3	0.8	0.3	0.9	-0.2
Exposure to tobacco smoke outside home	4.8	6.4	7.4	2.7	-2.4	-2.5
Comparative body size at age 10	0.9	2.5	5.2	2.3	-0.4	-1.5
Number of full brothers	1.1	1.4	2.1	0.8	-1.4	-1.2
Worry too long after embarrassment	0.2	0.4	0.5	-0.7	0.6	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.0	1.7	-0.9	-1.2
Wheeze or whistling in the chest in last year	0.8	1.4	3.4	1.8	0.7	0.6
Number of children fathered	0.5	0.6	0.9	-0.3	-1.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.9	-1.7	0.5	1.1
Age at first live birth	2.4	4.2	4.8	-2.2	2.1	1.8
Pulse wave peak to peak time	0.6	0.8	1.2	-0.1	1.1	1.0
Health satisfaction	3.3	4.3	7.3	2.7	-1.3	-2.0
Shortness of breath walking on level ground	0.2	0.2	0.3	0.5	0.6	0.0
Qualifications: College or University degree	0.7	2.1	3.3	-1.3	1.8	1.2
Eye problems/disorders: None of the above	0.7	0.8	2.0	1.4	-0.5	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.4	0.3	0.0
Emphysema/chronic bronchitis	0.9	1.0	2.2	1.5	-0.9	-0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	1.9	-1.4	-0.5	0.7
Neck or shoulder pain in last month	0.1	0.1	0.2	0.3	0.1	0.4
Medication: Blood pressure	0.2	0.4	0.4	0.6	-0.6	-0.7
Angina (self-reported)	0.8	1.1	1.6	1.3	-0.8	-0.9
Migraine (self-reported)	0.1	0.1	0.2	-0.4	0.1	-0.3
Medication: Ibuprofen	0.8	1.0	1.3	-0.6	1.1	1.2
Medication: Allopurinol	0.3	0.4	1.0	1.0	0.2	-0.3
Medication: Omeprazole	0.8	0.9	2.2	1.5	0.8	0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.5	0.7	-0.6	-0.5
Mean time to correctly identify matches	0.3	0.5	0.9	-0.3	-1.0	0.7
Heart disease (mother)	0.9	1.1	1.8	1.2	-0.5	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.5	0.6	0.3
Whole body fat mass	0.7	2.8	4.5	2.1	-1.2	-1.6
Leg fat mass (right)	0.7	2.7	4.6	2.1	-1.1	-1.5
Arm predicted mass (right)	0.1	0.3	0.4	0.3	0.6	-0.5
Pulse rate, automated reading	0.1	0.5	1.0	0.2	-0.6	-1.0
Alcohol intake frequency.	0.5	1.1	1.9	0.6	-0.9	-1.4
Comparative height size at age 10	0.3	1.9	2.3	-1.5	1.1	1.5
Number of full sisters	0.2	0.2	0.4	-0.0	-0.3	-0.7
Suffer from ‘nerves’	1.8	2.9	3.9	-1.4	2.0	1.6
Overall health rating	4.1	8.8	15.5	3.9	-2.1	-2.6
Chest pain or discomfort	1.1	1.6	4.6	2.2	-0.0	-0.4
Had major operations	1.4	1.6	3.3	-0.1	1.8	1.2
Age at last live birth	0.1	0.1	0.4	0.2	0.1	-0.6
Family relationship satisfaction	0.3	0.3	0.6	0.8	-0.2	-0.6
Leg pain on walking	1.0	1.3	2.7	1.6	-0.6	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.0	-0.2	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.5	0.7	0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.0	0.2	0.1
Medication: Aspirin	0.1	0.1	0.2	-0.2	0.2	-0.4
Supplements: Vitamin C	0.7	0.8	1.2	-0.8	-1.1	-0.8
Knee pain experienced in last month	7.6	11.9	15.7	-2.9	4.0	3.4
Hypertension (Self-reported)	0.8	2.1	3.3	1.3	-1.2	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.0	1.7	-0.1	-0.4
Illnesses of father: Heart disease	0.6	0.9	1.4	-0.9	1.2	0.6
Illnesses of siblings: Diabetes	0.3	0.4	1.1	1.0	0.4	0.0
Smoking status: Previous	1.5	2.2	2.3	1.5	-1.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.4	-2.1	1.5	1.0
Whole body fat-free mass	0.1	0.4	0.6	0.8	0.0	-0.8
Leg fat-free mass (right)	0.2	0.8	1.2	1.1	-0.4	-1.1
Arm fat percentage (left)	1.6	6.6	8.4	2.9	-2.2	-2.5
Average weekly red wine intake	0.3	0.5	0.9	0.3	0.7	1.0
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.0	1.7	-0.4	-0.9
Mood swings	2.6	4.6	5.1	2.3	-2.0	-2.2
Loneliness, isolation	0.4	0.5	1.2	1.1	0.4	0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.1	0.6	-0.7	-1.1
Ever had bowel cancer screening	1.0	1.2	3.0	1.7	0.7	0.4
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.2	-0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	5.2	5.6	10.5	3.2	-1.6	-1.9
Friendships satisfaction	0.1	0.2	0.4	0.6	-0.4	0.2
Qualifications: nursing, teaching	0.1	0.2	0.2	0.4	0.3	-0.5
Commuting to job workplace: Walk	0.8	0.9	1.9	-1.4	0.6	0.6
Eye problems/disorders: Cataract	1.6	1.9	5.1	-2.3	-0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.6	0.4	0.2
Medication for cholesterol	0.9	1.3	2.6	-0.2	1.6	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	3.8	1.8	-2.0	-2.0
Back pain experienced in last month	0.3	0.4	0.4	0.7	0.5	0.7
Mineral and other dietary supplements	0.3	0.4	0.8	0.5	-0.9	-0.5
Breast cancer (self-reported)	2.7	3.2	4.0	-1.5	1.9	2.0
Asthma (self-reported)	0.2	0.4	0.8	0.4	0.9	0.4
Osteoporosis (self-reported)	0.3	0.4	0.4	0.7	-0.5	0.7
Osteoarthritis (self-reported)	2.0	2.6	5.4	2.3	-0.9	-1.3
Medication: Aspirin	0.3	0.4	1.0	0.3	-0.2	-1.0
Medication: Gliclazide	0.1	0.1	0.2	-0.3	-0.1	0.5
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.4	-1.0	0.0
Smoking status: Current	1.1	1.7	2.7	1.6	-0.9	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	-1.2	0.6	0.4
Whole body water mass	0.1	0.5	0.7	0.8	-0.0	-0.9
Leg predicted mass (right)	0.2	0.8	1.1	1.1	-0.5	-1.1
Arm fat mass (left)	1.5	6.0	7.9	2.8	-2.1	-2.4
Number of self-reported non-cancer illnesses	1.0	1.8	4.8	2.2	-0.2	-0.8
Average weekly champagne plus white wine intake	0.9	1.2	1.6	-1.3	1.3	0.6
Miserableness	1.5	2.6	5.6	2.4	-1.0	-1.0
Guilty feelings	0.5	0.8	1.0	1.0	-0.6	-1.0
Wears glasses or contact lenses	2.0	2.3	2.8	-1.6	1.7	1.3
Ever taken oral contraceptive pill	0.7	0.8	1.6	-0.2	1.3	0.8
Hearing aid user	2.0	2.3	2.8	1.1	-1.7	-1.7
Mother’s age at death	0.3	0.3	0.8	0.5	-0.0	-0.9
Financial situation satisfaction	0.1	0.1	0.3	0.1	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	1.7	2.0	2.4	1.4	-1.5	-1.4
Commuting to job workplace: Public transport	2.2	2.6	3.4	1.7	-1.9	-1.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.2	0.4	-0.4	-0.5
Medication: Blood pressure	1.3	2.4	4.2	1.3	-1.1	-2.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.3	0.9	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.3	0.1	-0.6	-1.1
High cholesterol (Self-reported)	1.2	2.1	2.4	1.2	-1.5	-1.6
Medication: Bendroflumethiazide	0.9	1.4	2.0	0.2	-1.4	-1.4
Medication: Paracetamol	2.7	4.1	6.3	2.5	-1.6	-1.9
Medication: Lisinopril	0.5	0.6	1.8	-0.2	1.3	0.2
Medication: Atorvastatin	0.3	0.4	0.5	-0.4	-0.7	-0.7
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.4	0.8	0.1
Alcohol drinker status: Never	0.6	0.7	0.8	-0.8	0.9	0.8
Ever smoked	1.2	2.1	3.8	1.9	-1.1	-1.2
Basal metabolic rate	0.1	0.7	1.2	1.1	-0.2	-0.9
Leg fat percentage (left)	1.0	3.7	6.2	2.5	-1.4	-1.7
Arm fat-free mass (left)	0.1	0.7	1.2	1.1	0.0	-0.8
Number of operations (self-reported)	0.9	1.3	3.5	1.9	0.6	-0.3
Average weekly beer plus cider intake	0.0	0.0	0.1	0.2	0.1	0.2
Irritability	1.8	3.0	5.1	2.3	-1.3	-1.5
Risk taking	0.1	0.1	0.3	0.6	-0.0	0.0
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.9	0.4	0.7
Fractured/broken bones in last 5 years	0.5	0.6	0.9	0.7	0.9	0.8
Age started oral contraceptive pill	0.7	0.9	1.5	-0.7	0.8	1.2
Diastolic blood pressure, automated reading	0.8	2.6	3.1	-1.8	1.2	1.7
Ever depressed for a whole week	2.0	2.4	3.5	1.9	-1.5	-1.2
Unable to work because of sickness or disability	0.7	0.9	2.2	1.5	-0.4	-0.7
Commuting to job workplace: Cycle	1.0	1.2	2.4	0.1	1.6	1.0
Myopia	0.5	0.7	0.9	-0.7	0.9	1.0
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.8	-1.1	1.1	2.0
Cholesterol lowering medication	3.5	5.1	7.4	1.0	-2.6	-2.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	1.2	1.3	0.4
Pain experienced in last month	1.4	2.4	3.8	0.4	-1.9	-1.8
Supplements: Calcium	3.6	4.0	5.2	-1.8	2.3	1.8
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.1	0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.2	1.1	-0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.7	-0.3	-0.5
Heart disease (siblings)	0.2	0.3	0.5	-0.7	-0.3	-0.4
Alcohol drinker status: Previous	1.3	1.5	2.7	0.4	-1.7	-1.2
Pack years of smoking	0.0	0.1	0.1	0.2	0.2	0.3
Impedance of whole body	0.4	1.8	3.3	-1.8	0.8	1.2
Leg fat mass (left)	0.8	2.9	4.7	2.2	-1.2	-1.6
Arm predicted mass (left)	0.2	1.0	1.9	1.4	-0.1	-1.0