TWAS hub - TPSAB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2813	0.0864	5.5e-04	-0.004	NA	-0.001	NA	0.010	9.3e-01	NA	3.8e-01	NA	5.4e-02
2	GTEx	Esophagus Mucosa	0.1820	0.0590	7.3e-04	0.019	NA	0.026	NA	0.028	1.9e-02	NA	7.1e-03	NA	5.7e-03
3	YFS	Blood	0.3573	0.0327	0.0e+00	0.123	0.244	0.279	0.263	0.258	5.4e-38	5.1e-79	9.3e-92	7e-86	3.8e-84
4	TCGA	Bladder Urothelial Carcinoma	0.0780	0.0530	3.6e-03	0.005	0.018	0.002	NA	0.001	1.0e-01	1.1e-02	1.9e-01	NA	2.7e-01
5	TCGA	Breast Invasive Carcinoma	0.0775	0.0277	1.3e-07	0.008	0.037	0.036	NA	0.017	6.7e-03	4.4e-08	6.7e-08	NA	1.7e-04
6	TCGA	Cervical Squamous Cell Carcinoma	0.1440	0.0610	4.0e-04	0.008	0.075	0.098	NA	0.057	1.3e-01	1.5e-04	1.6e-05	NA	8.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.2	10.8	3.3	0.6	-1.6	-1.2	-1.9	0.8
Qualifications: None of the above	2.6	5.6	14.1	2.4	-0.7	-3.8	-0.5	-2.8	-2.3
Commuting to job workplace: Car/motor vehicle	2.5	2.9	5.9	-2.4	-2.1	-0.6	-1.9	0.1	-1.8
Taking other prescription medications	2.3	3.5	10.4	-1.1	0.0	-1.5	1.6	-3.2	-2.1
Pulse wave peak to peak time	2.3	2.7	4.6	-1.9	-0.1	1.9	-1.4	2.2	1.6
Illnesses of siblings: Diabetes	2.3	2.8	4.8	0.5	-1.7	-1.0	-2.2	-2.0	-2.0
Impedance of leg (right)	2.2	10.4	27.1	3.2	-3.0	-3.5	-0.6	-2.0	-5.2
Verbal and Numeric Reasoning (VNR)	1.9	4.6	15.0	-0.5	2.4	1.8	1.6	-1.0	3.9
Pulse wave Arterial Stiffness index	1.9	2.3	3.9	1.9	0.2	-1.9	1.1	-2.0	-1.2
Qualifications: College or University degree	1.9	6.1	20.1	-2.1	1.0	2.6	-0.9	1.9	4.5
Leg fat-free mass (right)	1.9	10.2	21.4	-3.7	3.6	2.8	0.3	2.2	4.6
Leg predicted mass (right)	1.9	10.0	21.3	-3.8	3.5	2.8	0.3	2.1	4.6
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	7.6	-2.8	-1.0	-0.9	-1.2	0.5	-0.9
Sensitivity / hurt feelings	1.7	3.0	7.8	0.4	0.5	-2.8	-2.0	-2.4	-0.0
Impedance of leg (left)	1.7	8.4	22.0	2.7	-2.8	-3.1	-0.3	-1.8	-4.7
Heart attack	1.7	2.1	4.0	-0.2	-1.9	-1.6	-1.1	-1.1	-2.0
Exposure to tobacco smoke at home	1.7	1.9	3.1	0.9	-1.8	-1.0	-1.6	-1.5	-1.3
Pulse wave reflection index	1.7	2.1	4.5	1.9	0.3	-2.1	-0.4	-1.1	-1.7
Chest pain or discomfort	1.7	2.5	6.0	1.4	0.7	-2.3	-0.2	-2.4	-1.2
Illnesses of father: Heart disease	1.7	2.4	13.1	-3.6	-0.1	-0.2	-0.0	0.8	-0.6
Ever had bowel cancer screening	1.7	1.9	4.3	0.3	2.1	1.4	1.3	-0.4	1.9
Mother’s age at death	1.7	2.1	7.0	0.3	1.8	1.3	0.9	0.1	2.7
Ever depressed for a whole week	1.7	2.0	5.7	2.4	2.3	0.1	-0.8	-0.7	0.2
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.1	-0.0	-2.0	-1.7	-1.2	-0.9	-2.0
Intelligence (Savage-Jansen 2018)	1.6	5.0	15.8	-1.0	2.5	2.2	0.4	-1.3	4.0
Reaction Time	1.6	3.1	9.6	0.7	-0.2	2.4	1.5	3.1	-0.6
HbA1C	1.6	1.8	5.0	0.2	0.4	0.9	1.0	1.9	2.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.4	0.5	2.3	1.5	2.1	0.1	0.4
Diabetes (father)	1.6	1.9	5.0	0.4	-0.7	-1.5	-2.2	-1.2	-1.5
Falls in the last year	1.6	2.2	11.4	-3.4	1.0	-0.5	-0.0	-0.2	0.8
Medication: Paracetamol	1.6	2.7	4.6	-0.5	-2.0	-2.1	-0.8	-1.9	-1.8
Qualifications: nursing, teaching	1.6	2.5	9.7	-1.0	0.1	3.1	0.0	0.8	1.9
Number of treatments/medications taken	1.5	2.6	5.4	-0.6	0.8	-1.0	2.2	-2.3	-1.9
Leg fat-free mass (left)	1.5	8.1	16.8	-3.4	3.2	2.5	0.2	1.9	4.1
Leg predicted mass (left)	1.5	8.1	16.5	-3.5	3.3	2.4	0.3	1.9	4.1
Pulse rate	1.5	2.5	6.3	2.1	-1.4	-0.5	1.2	-0.4	-2.5
Qualifications: A levels/AS levels or equivalent	1.5	3.3	10.7	-1.4	0.7	3.3	-0.2	1.9	1.8
Angina (self-reported)	1.5	2.0	3.7	-0.7	-1.0	-1.7	0.7	-1.9	-1.9
Illnesses of father: None of the above (group 1)	1.5	1.9	3.3	1.1	0.6	1.8	1.8	0.9	1.5
Respiratory disease	1.4	3.2	9.1	-0.8	0.3	-3.0	0.1	-3.0	-0.8
Angina	1.4	1.9	3.3	-0.7	-1.3	-1.5	0.6	-1.7	-1.8
Mean time to correctly identify matches	1.4	2.6	6.7	0.5	-0.0	2.6	1.7	2.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	7.7	-0.4	-0.0	-1.4	0.2	-0.5	-2.8
Whole body fat-free mass	1.4	7.8	15.8	-3.0	3.3	2.4	-0.4	2.3	4.0
Whole body water mass	1.4	7.7	15.9	-3.0	3.3	2.4	-0.3	2.2	4.0
Alcohol usually taken with meals	1.3	2.1	4.8	1.0	-0.0	1.6	-1.9	-0.9	2.2
Had menopause	1.3	1.6	5.2	0.8	0.7	1.8	2.3	0.2	0.2
Trunk fat-free mass	1.3	7.2	13.9	-2.7	3.1	2.3	-0.6	2.5	3.7
Alcohol intake versus 10 years previously	1.3	1.9	8.4	-1.0	2.9	-0.4	0.9	0.7	0.9
Father’s age at death	1.3	1.7	4.3	2.1	0.8	-0.9	-0.2	-2.0	0.5
Happiness	1.3	1.5	5.1	-1.8	-0.3	2.3	0.8	-0.1	0.2
Prospective memory result	1.3	1.6	4.2	0.3	-1.1	0.7	1.3	2.1	-1.4
Lung cancer (father)	1.3	1.5	2.6	0.4	-1.4	1.6	0.9	1.6	-0.9
Breastfed as a baby	1.3	1.6	3.7	0.2	1.9	1.5	1.4	-0.3	1.4
Emphysema/chronic bronchitis	1.3	1.4	3.6	-0.5	0.8	-1.9	-0.5	-0.8	-1.8
Myopia	1.3	1.9	4.7	-1.3	2.1	0.5	-0.8	0.0	2.2
Heart disease (siblings)	1.3	1.6	5.7	-0.8	-0.8	-2.4	-1.4	-1.0	-0.2
Alzheimer’s Disease (in father)	1.2	1.3	5.4	2.3	-0.0	-0.2	-1.1	-0.7	-0.7
Age at First Birth	1.2	1.7	6.2	0.4	0.2	2.5	-0.1	0.7	1.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	5.3	0.3	1.0	0.2	2.3	-1.2	-1.2
Relative age voice broke	1.2	1.8	4.2	-1.5	2.0	-0.2	0.2	1.2	1.7
Serious illness, injury or assault to yourself	1.2	1.5	3.2	1.8	-0.6	-0.5	0.1	-1.6	-1.5
Noisy workplace	1.2	1.5	4.5	1.0	0.2	-2.1	-0.1	-0.5	-1.8
Trunk predicted mass	1.2	6.9	13.5	-2.7	3.1	2.2	-0.8	2.3	3.7
Birth weight of first child	1.2	2.2	5.6	1.9	0.6	-2.4	-1.5	0.4	-1.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	7.2	-0.7	2.7	-0.8	0.7	-0.4	1.7
Medication: Blood pressure	1.2	2.1	7.3	1.0	-2.7	-0.1	-1.5	-0.3	-1.5
Medication: Ibuprofen	1.2	1.4	3.4	-1.8	1.0	-1.9	-0.3	-0.9	0.1
Medication: Allopurinol	1.2	1.5	4.4	-1.5	-0.3	2.1	-0.1	1.6	0.2
Knee pain experienced in last month	1.2	1.8	8.0	-0.7	-0.1	-2.8	-1.4	-0.4	-0.2
Osteoarthritis (self-reported)	1.2	1.5	4.8	-1.4	0.6	-2.2	-0.3	-0.6	-1.2
Medication: Paracetamol	1.2	1.8	4.5	0.1	-1.2	-2.1	-0.7	-1.8	-1.1
Medication: Atorvastatin	1.2	1.5	3.2	0.0	-1.1	-1.0	-1.6	-1.0	-1.8
Blood Eosinophil Count	1.1	8.6	29.9	-0.8	-3.1	-1.8	2.8	-0.5	-5.5
Ever had hysterectomy (womb removed)	1.1	1.3	3.2	-0.5	1.8	-0.3	1.8	-0.6	0.9
Nervous feelings	1.1	2.1	5.7	0.9	-0.6	-2.2	-1.1	-0.1	-2.4
Hair/balding pattern: Pattern 2	1.1	1.4	4.1	1.1	1.0	1.1	0.3	-0.8	2.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.5	1.9	0.9	-0.6	-1.2	-1.3	-0.1
Medication: Simvastatin	1.1	1.5	4.2	-1.5	0.1	1.0	1.2	2.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.5	-2.1	0.4	-1.4	-0.5	-1.1	-0.7
Ever highly irritable/argumentative for 2 days	1.1	1.4	5.2	1.4	-0.3	-0.5	-2.3	-0.7	0.3
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.2	1.3	1.5	-1.8	0.8	-0.6	0.2
Arm fat-free mass (right)	1.1	5.6	9.6	-2.7	3.1	2.1	-0.1	2.2	2.7
Wheeze or whistling in the chest in last year	1.1	2.0	5.2	0.4	0.9	-2.3	0.4	-1.4	-1.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.5	-0.4	-1.7	0.0	-0.5	-0.1	-2.1
Had major operations	1.1	1.3	3.8	0.4	-1.1	-1.6	-0.4	0.4	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.7	-1.2	1.1	0.4	-1.1	2.2	2.1
Mood swings	1.1	2.1	5.8	0.6	1.5	-2.4	0.5	-1.5	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.3	0.0	1.4	0.5	0.2	-1.2	1.8
Wears glasses or contact lenses	1.1	1.2	3.4	-0.1	-1.6	-1.2	-0.3	-0.2	-1.9
Commuting to job workplace: Public transport	1.1	1.3	4.0	-0.4	0.7	2.0	0.3	1.2	1.4
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.0	-1.1	1.7	-0.7	0.7	-1.7	0.4
Basal metabolic rate	1.1	6.3	11.8	-3.0	3.0	2.1	-0.2	1.9	3.4
Impedance of whole body	1.1	5.6	11.0	2.9	-2.2	-2.5	0.3	-1.6	-3.3
Mean Putamen Volume	1.0	1.2	4.6	-0.7	-0.0	2.1	0.8	1.1	0.3
Fasting Glucose	1.0	1.1	1.8	-0.0	1.4	1.2	0.9	1.2	1.2
Diabetes (mother)	1.0	1.3	4.1	0.7	-1.0	-1.1	-0.8	-0.7	-2.0
Mouth/teeth dental problems	1.0	1.6	4.0	-0.7	1.7	0.9	1.1	-0.3	2.0
Fluid intelligence score	1.0	2.1	7.6	-0.4	1.8	1.0	0.0	-0.8	2.8
Headache pain in last month	1.0	1.7	3.9	2.0	0.5	-1.1	0.8	-1.9	-0.8
Medication for pain relief, constipation, heartburn	1.0	1.7	4.5	2.1	0.5	1.6	-0.1	1.3	1.2
Heart disease (mother)	1.0	1.2	3.4	-0.3	-0.6	-1.9	-1.7	0.3	0.5
Pulse rate, automated reading	1.0	3.2	10.8	3.3	-2.4	-0.5	-0.0	0.1	-1.5
Asthma (self-reported)	1.0	2.0	6.7	-0.2	-0.0	-2.1	0.6	-2.6	-0.7
Medication: Gliclazide	1.0	1.2	2.7	-0.8	-1.0	-1.6	-1.5	0.8	-0.1
Medication: Bendroflumethiazide	1.0	1.5	4.3	-0.7	-2.1	0.7	0.1	1.7	-0.8
Alcohol drinker status: Never	1.0	1.2	2.5	1.6	0.1	-1.6	0.1	-1.4	-0.7
Unable to work because of sickness or disability	1.0	1.3	3.4	1.7	-0.1	0.1	1.2	-0.4	-1.8
Supplements: Calcium	1.0	1.1	5.7	2.4	0.1	-0.5	-0.1	-0.6	0.4
Alzheimer’s Disease (including proxy)	0.9	1.3	2.2	0.6	-0.7	-1.1	-1.5	-1.4	-1.2
Prostate Cancer	0.9	1.3	3.8	0.6	-0.2	-1.9	-0.8	-0.4	-1.6
Current tobacco smoking	0.9	1.5	4.2	-0.5	1.4	-2.1	0.6	0.5	-1.4
Multivitamins +/- minerals	0.9	1.1	2.7	1.6	0.9	-0.3	0.0	-1.4	1.0
Illnesses of siblings	0.9	1.2	3.1	-0.1	1.4	0.9	1.1	0.4	1.8
High blood pressure (siblings)	0.9	1.2	3.3	-0.3	-1.0	-0.5	-1.1	-1.3	-1.8
Medication: Seretide 50 evohaler	0.9	1.0	2.9	-0.7	0.2	-1.7	0.5	-1.6	-0.1
Arm predicted mass (right)	0.9	4.8	8.4	-2.4	2.9	1.9	-0.3	2.2	2.4
Overall health rating	0.9	2.0	7.5	0.2	-0.6	-1.6	1.1	-0.4	-2.7
Mineral and other dietary supplements	0.9	1.2	5.1	0.4	-2.3	-0.8	-1.2	0.1	-0.2
Smoking status: Current	0.9	1.4	4.5	-0.6	1.4	-2.1	0.3	0.5	-1.1
Arm fat-free mass (left)	0.9	4.5	7.2	-2.5	2.7	1.7	-0.2	2.0	2.5
Fractured/broken bones in last 5 years	0.9	1.1	3.0	-0.3	1.6	-0.6	0.8	1.7	0.1
Severe depression (siblings)	0.8	0.9	5.2	-0.0	-0.1	-0.2	-2.3	-0.2	0.4
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	0.4	-0.4	-1.0	-0.9	-1.0	-1.6
Neuroticism score	0.8	1.6	2.9	1.3	0.0	-1.7	-1.1	-1.2	-1.6
Hair/balding pattern: Pattern 3	0.8	1.2	2.8	-1.7	-1.3	-0.8	-0.9	-0.5	-1.0
Depression (self-reported)	0.8	1.0	2.7	1.1	1.6	-0.1	0.8	-0.9	-0.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.8	-0.5	-1.5	0.7	-1.7	0.4	-0.3
Number of full brothers	0.8	1.1	5.7	-0.3	0.3	-2.4	-0.0	-0.4	-0.5
Shortness of breath walking on level ground	0.8	0.9	1.7	-0.9	1.2	-0.6	1.0	0.3	-1.3
Migraine (self-reported)	0.8	1.0	3.5	-0.2	-1.2	-0.5	1.9	-0.4	-0.7
Family relationship satisfaction	0.8	1.0	3.0	-1.4	-0.2	1.7	0.8	0.7	-0.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-1.1	1.2	0.6	0.1	0.7	1.6
Diabetes diagnosed by doctor	0.8	1.2	3.5	-0.4	-0.7	-1.7	-1.9	-0.6	-0.3
Friendships satisfaction	0.8	0.9	2.6	-1.6	-0.8	0.9	-1.0	-0.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.6	0.2	0.6	-0.8	-1.3	-0.3	1.6
Number of self-reported non-cancer illnesses	0.8	1.4	5.0	-2.2	0.1	0.9	1.6	0.1	-0.4
Average weekly champagne plus white wine intake	0.8	1.1	4.6	-1.1	-0.7	0.4	-2.1	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.3	0.9	0.3	-1.3	-0.4	-1.5	-0.7
Pack years of smoking	0.8	1.1	4.2	0.2	-0.8	-0.8	0.7	-0.8	-2.1
Arm predicted mass (left)	0.8	4.0	6.5	-2.4	2.5	1.5	-0.4	1.8	2.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.5	-1.0	-0.7	-0.6	-1.2	-1.2	-0.1
Ulcerative Colitis (UC)	0.7	1.3	5.3	2.3	0.5	0.1	1.4	0.1	-0.7
Lung FEV1/FVC ratio	0.7	3.5	6.5	-1.4	-2.5	-0.9	-2.6	1.9	1.3
Chronotype (morning person)	0.7	1.6	3.9	0.0	-1.9	-1.0	-0.8	-0.7	-2.0
Average weekly spirits intake	0.7	0.9	3.4	-0.7	0.5	1.8	0.1	0.0	1.1
Relative age of first facial hair	0.7	1.4	3.4	-0.1	1.8	0.1	1.3	1.6	0.7
Medication for hormone replacement therapy	0.7	0.8	2.2	-0.7	1.1	0.6	0.7	-0.0	-1.5
Medication: Metformin	0.7	1.0	2.9	-0.9	0.5	-1.7	-1.4	-0.3	0.3
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.9	-0.4	-0.4	-1.1	-1.4	-1.1
Supplements: Glucosamine	0.7	0.9	2.0	0.2	1.4	-1.1	0.3	-1.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	-0.1	0.2	1.1	1.3	1.2	0.6
Hearing difficulty/problems with background noise	0.7	1.1	3.1	0.0	1.0	-1.8	-0.6	-1.4	-0.4
Had other major operations	0.7	0.9	2.5	-0.1	1.6	-0.4	0.5	-1.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.2	-0.6	-2.1	-0.4	-1.1	-1.7	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	4.6	-0.3	0.4	2.1	0.0	0.8	0.2
Asthma	0.7	1.4	4.1	-0.1	0.1	-2.0	0.8	-1.9	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.6	-0.7	0.0	2.2	-1.3	2.1	1.4
Length of working week for main job	0.7	0.8	2.0	-1.0	0.3	0.5	0.5	1.4	0.9
Peak expiratory flow (PEF)	0.7	1.5	4.6	-1.6	-0.3	0.5	-1.2	2.1	0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.5	1.9	-0.2	0.3	-0.3	1.2	0.1
Leg fat percentage (right)	0.7	2.5	8.3	-0.3	-1.3	-1.8	0.4	-1.3	-2.9
Exposure to tobacco smoke outside home	0.7	0.9	3.2	-0.8	-1.8	-0.5	-0.2	-0.9	-0.6
Age at first live birth	0.7	1.2	2.7	-0.7	-1.5	1.6	-0.9	-0.7	-0.3
Eye problems/disorders: None of the above	0.7	0.8	2.2	0.6	0.6	1.2	0.3	0.7	1.5
Alcohol intake frequency.	0.7	1.7	3.7	1.1	1.5	-1.6	0.6	-1.9	-0.4
Suffer from ‘nerves’	0.7	1.1	2.6	1.2	-0.5	-1.2	0.1	-0.8	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.6	0.3	-0.8	1.2	0.8	1.0	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	5.3	0.0	-1.0	0.1	-2.3	-0.7	-0.5
Financial situation satisfaction	0.7	0.8	2.8	-0.9	0.8	-0.5	0.0	-0.8	-1.7
Medication: Blood pressure	0.7	1.3	4.4	-2.1	0.5	0.6	1.3	0.3	1.1
Ovarian Cancer	0.6	0.8	1.8	1.1	-0.5	-0.8	-1.3	-0.1	-1.0
Blood White Count	0.6	4.3	12.0	0.1	-2.8	-3.5	0.0	-0.3	-2.4
Neuroticism	0.6	1.4	2.5	1.2	1.4	-1.6	0.3	-0.6	-1.5
Hearing difficulty/problems: Yes	0.6	1.0	3.3	0.0	1.8	-1.3	-0.1	-1.0	-0.1
Pack years adult smoking proportion	0.6	0.8	3.5	0.2	-0.7	-0.4	0.9	-0.3	-1.9
Townsend deprivation index at recruitment	0.6	0.9	2.3	-1.3	-0.1	0.1	1.5	-0.9	-0.6
Average weekly fortified wine intake	0.6	0.7	3.1	-0.1	-0.8	0.6	-0.4	1.8	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.2	-0.3	-1.8	-0.5	-0.6	-1.8	-1.2
Number of incorrect matches in round	0.6	1.0	2.2	-0.8	1.5	-1.2	0.2	-1.0	0.8
Allergy	0.6	1.3	3.3	-1.2	0.2	1.0	1.2	1.8	0.8
Medication: Ramipril	0.6	0.7	1.5	-0.2	-1.2	0.9	-0.9	-0.8	0.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.1	-0.2	-0.6	1.7	-1.8	2.0	0.9
Standing height	0.6	6.1	14.9	-1.7	2.7	2.2	-0.9	2.4	3.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.0	-0.0	0.2	-1.3	0.0	-1.1	-1.4
Number of children fathered	0.6	0.6	1.8	0.7	0.7	-1.3	0.3	-1.0	-0.0
Medication: Omeprazole	0.6	0.7	1.8	0.6	0.1	-1.2	-0.5	-1.3	-0.6
Number of full sisters	0.6	0.7	3.1	-0.4	-0.6	-0.1	-0.8	-1.8	0.4
Average weekly red wine intake	0.6	0.9	2.3	-0.9	0.8	1.1	-0.1	0.8	1.5
Loneliness, isolation	0.6	0.8	1.6	1.1	0.5	-0.5	-0.9	-1.3	0.9
Commuting to job workplace: Walk	0.6	0.7	1.6	-0.3	0.7	1.3	0.3	-0.4	1.3
Medication for cholesterol	0.6	0.9	2.1	1.4	-1.1	-0.8	-1.1	-0.0	-0.4
Hearing aid user	0.6	0.6	3.2	0.5	1.8	0.2	0.3	-0.5	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.8	1.2	0.3	1.1	0.3	1.0	-1.1	-1.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.5	1.2	1.0	-0.4	0.2	-1.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.9	-1.1	1.2	1.4	0.5	0.4	0.2
Medication: Lisinopril	0.6	0.7	3.3	-0.7	0.1	0.4	-0.7	-0.2	1.8
Ever smoked	0.6	1.0	2.6	-0.3	1.6	1.2	1.0	0.7	0.6
Leg fat percentage (left)	0.6	2.0	5.8	-0.7	-0.9	-1.7	0.7	-1.2	-2.4
Number of operations (self-reported)	0.6	0.9	2.0	-0.0	0.4	-1.2	1.1	-1.4	-0.9
Irritability	0.6	1.0	3.1	0.5	-0.4	-1.7	-1.0	-0.0	-1.2
Age started oral contraceptive pill	0.6	0.8	2.1	0.5	1.4	-0.0	1.4	-0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.6	-0.5	0.9	0.7	0.3	-0.6	1.6
Depressed Affect (Nagel 2018)	0.5	1.1	3.2	-0.4	0.9	-1.2	-0.1	-1.8	-1.0
Neuroticism (Nagel 2018)	0.5	1.3	2.6	-0.0	1.5	-1.6	0.2	-1.3	-0.9
Breast Cancer	0.5	1.3	3.4	0.1	-0.4	-1.8	-1.0	-1.1	-1.4
LDL Cholesterol	0.5	0.8	3.4	1.8	-0.8	-0.9	0.0	0.0	0.0
Rheumatoid Arthritis	0.5	0.7	1.5	-0.8	1.2	0.1	-0.9	0.9	0.3
Height	0.5	8.9	20.7	-2.3	3.1	3.1	-1.7	2.4	4.5
Smoking Status	0.5	1.1	2.3	-1.0	0.2	-1.5	-0.2	1.1	-1.5
Hypothyroidism (self reported)	0.5	1.1	3.1	-1.8	0.5	0.7	0.6	0.1	1.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	0.2	-0.4	-1.5	-1.4	-0.7	-0.3
Hand grip strength (left)	0.5	1.4	3.8	-0.1	-0.6	1.9	0.2	1.8	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.5	-0.6	-0.4	-0.4	-0.4	-0.9	-1.6
Medication: Co-codamol	0.5	0.6	2.2	-0.1	1.5	-0.3	-0.0	-1.1	0.5
Fed-up feelings	0.5	0.9	2.1	1.4	-0.1	-0.7	0.4	-0.7	-1.5
Forced vital capacity (FVC)	0.5	1.7	5.4	0.0	0.5	2.3	-0.8	1.8	1.0
Diabetes (self-reported)	0.5	0.7	2.3	-0.2	-0.2	-1.3	-1.5	-0.6	0.1
Weight	0.5	2.4	6.1	-2.5	1.6	1.3	0.5	1.0	1.6
Impedance of arm (right)	0.5	2.4	5.1	2.2	-1.9	-1.2	0.2	-1.7	-1.1
Hip circumference	0.5	2.2	6.2	-2.5	1.4	1.1	1.5	0.6	1.0
Number of live births	0.5	0.7	1.9	0.6	1.0	-0.6	-0.2	-1.4	0.7
Mouth/teeth dental problems: Dentures	0.5	0.8	2.1	1.1	0.5	-1.4	0.7	-0.2	-1.0
Medication: Cholesterol lowering	0.5	0.7	1.6	-0.1	-0.9	1.2	-0.7	0.9	-0.7
Illnesses of mother	0.5	0.6	1.7	-1.3	0.9	0.0	0.8	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.8	-1.3	-0.1	1.2	-0.1	1.1	-0.1
Gout (self-reported)	0.5	0.6	1.5	-1.1	-0.4	0.9	0.2	1.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.7	-0.7	0.5	0.3	0.8	-0.4	1.9
Birth weight	0.5	1.0	3.5	-0.6	0.4	-0.9	-1.9	1.0	-0.6
Age at last live birth	0.5	0.7	1.7	-1.3	-0.6	1.2	0.5	-0.1	0.7
Miserableness	0.5	0.9	2.4	0.8	-0.1	-0.6	-1.1	-1.5	-0.9
Average weekly beer plus cider intake	0.5	0.7	2.4	-0.6	1.6	0.1	1.1	-0.7	-0.2
Commuting to job workplace: Cycle	0.5	0.6	1.4	1.2	-0.2	-0.6	-1.2	-0.7	0.3
Alcohol drinker status: Previous	0.5	0.6	1.4	-0.4	0.4	0.7	0.9	-0.6	1.2
Depression (Nagel 2018)	0.4	0.6	1.3	-0.9	0.5	-0.0	0.5	-0.9	-1.2
Worry (Nagel 2018)	0.4	0.8	2.0	0.3	1.4	-1.3	0.7	-0.7	-0.5
Irritable Bowel Disease (IBD)	0.4	1.0	3.2	1.8	0.6	0.5	1.3	0.2	-0.7
Body Mass Index (BMI) (2010)	0.4	0.5	1.6	-0.8	-0.8	-1.3	0.0	0.0	0.0
Neuroticism (2016)	0.4	0.6	1.8	-1.0	1.4	-0.6	0.5	0.2	0.6
Systolic Blood Pressure	0.4	2.1	4.3	-0.9	-1.7	2.1	1.5	1.5	0.2
Cardiovascular Disease	0.4	1.3	2.4	-1.4	-1.6	0.8	0.7	-0.3	-1.4
Lung FVC	0.4	2.0	8.3	2.9	-0.7	1.4	-0.9	0.6	-0.2
Systolic blood pressure, automated reading	0.4	1.2	4.0	0.0	-0.3	1.4	2.0	0.9	-0.6
Supplements: Zinc	0.4	0.4	1.7	-0.0	-0.3	-0.7	1.3	-0.4	-0.3
Maternal smoking around birth	0.4	0.6	1.4	-0.4	-0.6	-1.1	0.3	-1.2	-0.7
Age when periods started (menarche)	0.4	1.1	2.0	-0.9	-0.4	-1.2	-1.4	-1.4	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.3	1.5	-1.1	0.4	-0.9	-0.4	-1.0
Medication: Levothyroxine sodium	0.4	0.7	3.1	-0.7	0.5	0.1	0.4	-0.3	1.7
Financial difficulties in last 2 years	0.4	0.6	2.1	0.5	1.4	-0.8	-0.4	0.0	0.5
Worrier / anxious feelings	0.4	0.8	2.5	1.0	1.6	-0.6	0.3	-0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.3	0.3	-0.0	0.7	1.2	0.6	-0.5
Medication: Lansoprazole	0.4	0.4	1.0	-1.0	0.2	0.7	-0.9	0.1	-0.5
Impedance of arm (left)	0.4	2.0	4.5	2.1	-1.3	-1.4	0.6	-1.6	-1.1
Tense / ‘highly strung’	0.4	0.6	1.4	1.1	0.2	-1.2	-0.4	-1.0	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.5	0.8	1.0	0.3	0.3	-1.2	0.9
Loud music exposure frequency	0.4	0.5	1.3	0.4	-0.5	-0.9	-0.5	-0.3	-1.1
Blood clot in the leg (DVT)	0.4	0.5	1.8	-0.6	0.8	0.5	0.1	-0.5	1.4
Forced vital capacity (FVC), Best measure	0.4	1.6	5.1	-0.3	0.8	2.3	-0.8	1.7	0.7
Body fat percentage	0.4	1.4	3.8	-0.1	-0.8	-1.0	1.2	-1.3	-1.9
Health satisfaction	0.4	0.5	1.8	-0.2	1.3	-0.4	-0.0	-0.7	-0.8
Neck or shoulder pain in last month	0.4	0.6	1.3	-1.2	0.7	0.1	-0.2	1.0	0.8
Leg pain on walking	0.4	0.5	2.2	-0.7	1.5	-0.4	0.1	-0.4	0.2
Supplements: Vitamin C	0.4	0.4	1.0	0.9	-0.0	0.5	0.7	1.0	-0.3
Back pain experienced in last month	0.4	0.6	1.1	-0.6	0.4	-1.1	1.0	-0.8	-0.0
Risk taking	0.4	0.6	2.6	0.3	0.6	-0.1	1.6	-0.6	-0.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.0	1.3	1.4	0.2	-0.4	1.2	1.2
Crohns Disease (2017)	0.3	0.6	1.4	0.9	0.9	1.2	0.9	-0.0	-0.2
Blood Platelet Count	0.3	3.7	11.7	3.4	-0.3	-2.4	1.8	-1.2	-0.3
Heel T-Score	0.3	2.4	5.8	-2.4	-1.9	-0.6	-1.2	-1.5	-1.0
Waist Hip Ratio (WHR)	0.3	1.2	4.1	-0.3	-2.0	-0.8	0.1	0.2	-1.6
Trunk fat percentage	0.3	1.2	2.7	-0.1	-0.6	-0.6	1.4	-1.2	-1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.2	-1.1	0.3	0.4	0.3	-0.5	0.2
Stomach or abdominal pain in last month	0.3	0.3	0.9	0.7	0.0	0.2	-0.1	1.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-1.0	0.2	0.1	-1.1	-0.7	0.2
Time employed in main current job	0.3	0.4	1.1	-0.3	0.0	1.1	-0.2	1.0	0.3
Medication: Amlodipine	0.3	0.4	1.4	0.1	-1.2	0.8	0.3	-0.1	-0.4
Comparative height size at age 10	0.3	1.5	3.6	-0.2	1.9	1.3	-0.1	0.2	1.9
Smoking status: Previous	0.3	0.4	0.8	0.8	-0.5	0.9	0.1	-0.1	-0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.3	-0.2	-0.8	-0.7	0.9	0.7
Long-standing illness, disability or infirmity	0.3	0.4	1.3	0.3	0.9	0.2	0.4	-1.2	-0.2
High cholesterol (Self-reported)	0.3	0.6	0.9	-0.9	-0.4	0.9	0.7	0.7	-0.9
Cholesterol lowering medication	0.3	0.4	2.0	-1.4	0.2	-0.3	0.4	-0.0	-0.4
Schizophrenia (2018)	0.2	0.5	1.5	1.2	1.2	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.3	1.0	1.0	0.8	0.0	0.0	0.0	0.0
Lupus	0.2	0.4	0.9	-0.7	-0.2	1.0	0.6	-0.5	0.3
Triglycerides	0.2	0.3	1.0	1.0	0.1	-0.9	0.0	0.0	0.0
Blood Red Count	0.2	2.0	6.5	-0.8	-1.4	0.4	1.5	-0.9	-2.5
Allergy or Eczema	0.2	0.5	1.7	1.3	-0.3	0.7	0.1	-0.8	-0.4
Tanning	0.2	2.6	7.0	0.6	-1.9	-2.1	0.4	-0.2	-2.6
Vitamin and mineral supplements	0.2	0.2	0.6	-0.1	0.0	-0.6	-0.7	0.4	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.3	-0.6	0.4	-0.4	-0.7	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.1	-0.1	-0.1	-0.1	-0.4	-0.9
High blood pressure	0.2	0.6	2.0	-0.9	-0.4	0.1	0.6	-1.4	-0.3
Medication: Atenolol	0.2	0.3	0.9	0.5	-0.6	-0.1	-0.1	-0.5	-1.0
High blood pressure (mother)	0.2	0.3	1.2	-0.5	-0.0	1.1	0.3	0.1	0.7
Body mass index (BMI)	0.2	0.6	2.9	-1.7	0.4	0.4	0.8	-0.0	-0.2
Waist circumference	0.2	0.8	4.4	-2.1	-0.1	0.5	0.5	0.4	-0.1
Pain all over the body in last month	0.2	0.2	0.5	-0.2	-0.3	-0.3	-0.6	-0.7	-0.1
Arm fat percentage (right)	0.2	0.6	1.6	-0.5	-0.5	-0.1	1.2	-1.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	0.4	1.0	0.3	0.4	-0.5	-0.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.6	1.3	-0.7	-0.0	-0.5	-0.9	-0.7
Glaucoma (self-reported)	0.2	0.3	0.8	0.6	0.7	-0.0	0.1	-0.9	0.3
Comparative body size at age 10	0.2	0.5	2.4	0.1	0.5	-0.1	0.5	1.6	0.4
Worry too long after embarrassment	0.2	0.3	0.7	-0.9	0.8	-0.3	-0.6	-0.1	0.3
Medication: Aspirin	0.2	0.2	0.6	-0.7	0.1	-0.8	0.3	-0.4	-0.0
Eye problems/disorders: Cataract	0.2	0.3	0.6	-0.4	-0.6	-0.5	-0.5	-0.3	-0.8
Breast cancer (self-reported)	0.2	0.2	0.5	-0.3	0.7	0.7	0.3	-0.5	-0.0
Medication: Aspirin	0.2	0.3	1.3	-1.1	-0.0	-0.6	0.2	-0.2	-0.3
Arm fat mass (left)	0.2	0.8	3.1	-1.8	0.6	0.6	1.0	-0.2	0.3
Guilty feelings	0.2	0.3	0.9	-0.6	0.6	-0.4	-0.1	0.3	-0.9
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.4	0.3	-0.2	0.9	0.9	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.0	0.3	-0.7	-0.7	-0.2	-0.2
Pain experienced in last month	0.2	0.3	0.6	0.3	-0.5	0.8	-0.5	0.5	0.5
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.3	0.4	-0.7	0.7	-0.6	-0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	0.9	0.4	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.1	0.2	0.6	0.7	-0.2	-0.1	0.2	-0.0	0.6
Schizophrenia (2014)	0.1	0.3	0.9	0.8	1.0	0.0	0.0	0.0	0.0
BMI	0.1	0.8	2.5	-1.6	0.4	-0.3	1.3	0.3	-0.1
Hand grip strength (right)	0.1	0.4	0.7	-0.3	-0.6	0.6	-0.3	0.6	-0.9
Sitting height	0.1	0.8	1.2	0.9	1.1	0.5	-1.1	0.7	0.9
Trunk fat mass	0.1	0.4	0.7	-0.9	0.2	-0.1	0.8	-0.6	-0.6
Past tobacco smoking	0.1	0.3	0.6	-0.4	-0.7	-0.8	-0.4	-0.3	0.1
Arm fat mass (right)	0.1	0.5	2.2	-1.5	0.4	0.3	0.8	-0.4	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	0.3	-0.4	0.3	0.2	0.5	0.6
Whole body fat mass	0.1	0.4	1.1	-1.1	0.4	0.0	0.9	-0.4	-0.4
Leg fat mass (right)	0.1	0.4	1.2	-1.1	0.0	-0.2	0.4	-0.2	-1.1
Hypertension (Self-reported)	0.1	0.4	0.9	-0.9	-0.4	-0.1	0.5	-0.9	-0.1
Arm fat percentage (left)	0.1	0.6	1.6	-0.6	-0.3	-0.1	1.2	-1.1	-0.6
Osteoporosis (self-reported)	0.1	0.2	0.5	0.7	0.1	0.1	-0.3	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.3	-0.5	-0.3	-0.5	-1.1	0.0	-0.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.4	0.0	-0.4	-0.4	-0.4	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.5	-0.1	-0.3	1.0	-0.8	-0.7
Leg fat mass (left)	0.1	0.5	1.9	-1.4	0.4	-0.2	0.7	-0.3	-0.8
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.2	0.4	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.1	0.2	0.1	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.2	0.1	0.4	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	1.5	1.2	1.1	0.3	-0.4	1.0	0.4

Hub : Genes

TPSAB1

Models

Trait associations