TWAS hub - TRAM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Ovary	0.4720	0.1270	7.1e-04	0.068	NA	0.117	NA	0.123	9.5e-03	NA	8.7e-04	NA	6.3e-04
2	METSIM	Adipose	0.0516	0.0193	2.0e-03	0.016	0.024	0.020	0.025	0.027	1.4e-03	1.3e-04	4.5e-04	9.2e-05	4.7e-05
3	NTR	Blood	0.0355	0.0113	2.3e-04	0.017	0.022	0.020	0.022	0.016	2.7e-06	9.3e-08	2.5e-07	1.2e-07	4.2e-06
4	ROSMAP	Brain Pre-frontal Cortex	0.1529	0.0328	7.4e-10	0.084	0.078	0.067	0.073	0.081	5.8e-11	3.2e-10	5.9e-09	1.1e-09	1.3e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Diverticular disease/diverticulitis (self-reported)	5.3	6.3	12.3	-1.9	3.5	-2.4	-1.9
Eye problems/disorders: Glaucoma	5.2	6.1	8.6	-1.9	2.1	-2.9	-2.8
Birth weight of first child	4.9	8.8	15.0	0.9	-2.7	3.5	3.9
Basal cell carcinoma (self-reported)	4.9	5.9	10.4	0.0	2.1	-2.9	-3.2
Bipolar Disorder (2011)	4.6	4.5	6.1	0.6	-2.5	2.5	2.4
Noisy workplace	4.6	5.6	9.3	-1.3	-1.8	2.9	3.0
Gout (self-reported)	4.2	5.8	13.6	-1.3	2.1	-1.9	-3.7
Glaucoma (self-reported)	4.1	4.8	8.3	-1.5	1.8	-2.4	-2.9
Family relationship satisfaction	3.0	3.7	12.3	-3.5	-0.8	-1.4	0.2
Rheumatoid Arthritis	2.9	4.1	7.4	-0.6	1.6	-2.5	-2.7
Blood Platelet Count	2.9	34.0	71.4	-4.8	4.6	-8.4	-4.5
Shortness of breath walking on level ground	2.9	3.5	4.5	-1.1	-2.0	2.0	2.1
Number of children fathered	2.8	3.2	8.2	-0.4	-0.9	1.9	2.9
Commuting to job workplace: Public transport	2.8	3.4	7.5	1.3	-2.7	1.6	1.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	4.5	0.3	-2.1	2.1	1.7
Migraine (self-reported)	2.5	3.1	6.8	0.9	-1.6	1.4	2.6
Medication: Allopurinol	2.5	3.4	6.3	-0.8	2.3	-1.0	-2.5
Illnesses of father: None of the above (group 1)	2.5	3.1	8.7	0.3	2.9	-1.2	-1.5
Average weekly fortified wine intake	2.4	2.8	4.6	0.1	-2.1	2.1	1.6
Commuting to job workplace: Car/motor vehicle	2.3	2.6	6.5	-0.8	2.5	-1.0	-1.6
Alzheimer’s Disease (in father)	2.2	2.4	7.0	1.4	2.6	-0.6	-0.4
Age at last live birth	2.2	3.1	8.8	0.7	-1.4	3.0	1.2
Handedness (chirality/laterality): Left-handed	2.2	2.6	5.5	-0.3	-1.0	2.0	2.3
Ever had hysterectomy (womb removed)	2.0	2.3	4.2	-1.2	-0.6	1.7	2.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.2	1.3	-1.8	1.2	1.6
Impedance of leg (right)	1.9	9.0	13.6	2.7	1.7	-3.7	-3.5
Fed-up feelings	1.9	3.5	6.0	-2.0	0.8	-2.5	-1.8
Eye problems/disorders: Cataract	1.9	2.2	6.7	-0.2	-1.1	2.6	0.9
Reaction Time	1.8	3.4	5.7	-0.9	-2.4	1.6	2.1
Schizophrenia (2014)	1.8	4.0	8.5	0.7	-2.3	2.9	1.2
Vitamin and mineral supplements	1.8	2.4	7.6	-0.7	2.8	-1.2	-0.5
Knee pain experienced in last month	1.8	2.8	5.7	-0.7	-2.4	2.2	0.6
Medication: Atorvastatin	1.8	2.2	5.0	-0.9	-0.4	-2.2	-1.6
Age at First Birth	1.7	2.5	6.6	0.1	-2.6	1.3	1.3
Chronic bronchitis/emphysema (father)	1.7	2.0	2.1	1.4	-1.5	1.4	1.4
Impedance of leg (left)	1.7	8.5	16.2	2.4	1.6	-4.0	-3.1
Happiness	1.7	2.0	4.5	-2.1	0.7	-1.7	-0.6
Number of full brothers	1.7	2.1	4.5	-1.3	-2.1	0.9	1.2
Miserableness	1.7	3.0	6.0	-2.5	-0.5	-2.3	-0.8
Medication: Bendroflumethiazide	1.7	2.6	7.7	0.5	-2.8	1.3	0.9
Lupus	1.6	2.4	8.0	-0.2	0.6	-2.8	-1.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	5.6	0.1	2.4	-1.1	-1.2
Supplements: Zinc	1.6	1.8	3.1	0.7	-1.7	1.3	1.4
Medication: Ventolin 100micrograms inhaler	1.6	2.1	6.0	-0.1	-0.7	1.4	2.4
Medication: Ibuprofen	1.6	1.9	2.1	1.3	-1.5	1.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	2.9	1.5	1.3	-0.8	-1.7
Ever taken oral contraceptive pill	1.6	1.8	3.0	0.5	1.0	-1.6	-1.7
Multivitamins +/- minerals	1.5	2.0	6.0	-0.2	-2.5	0.7	1.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	3.2	-1.1	1.3	-1.8	-1.2
Pulse rate	1.5	2.6	5.1	-0.4	-2.2	1.3	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.8	-1.0	-0.6	1.1	2.2
Back pain experienced in last month	1.5	2.1	5.2	0.5	-0.4	1.7	2.3
Length of working week for main job	1.4	1.6	4.6	0.9	2.1	0.6	0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.8	5.5	2.4	-1.2	-0.2	-0.2
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.0	-1.4	1.3	-1.7	-0.0
Illnesses of siblings	1.3	1.8	5.0	1.0	2.2	1.1	0.1
Peak expiratory flow (PEF)	1.3	3.1	7.0	2.6	0.5	-1.7	-1.5
Illnesses of father: Heart disease	1.3	1.8	3.9	-1.4	-2.0	0.9	0.7
Ever depressed for a whole week	1.3	1.7	3.4	0.4	1.0	-1.8	-1.5
Bipolar Disorder or Schizophrenia	1.2	3.0	4.8	0.9	-2.1	2.2	1.5
LDL Cholesterol	1.2	1.9	6.6	0.6	0.3	-2.6	-0.7
Blood Eosinophil Count	1.2	9.2	13.2	3.5	2.8	-1.9	-3.6
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	3.5	-0.8	-0.8	1.9	0.9
Severe depression (siblings)	1.2	1.4	3.3	-0.4	-1.8	0.8	1.2
High blood pressure (mother)	1.2	1.6	5.3	0.5	0.5	-0.8	-2.3
Pain all over the body in last month	1.2	1.3	2.0	1.1	-0.6	1.2	1.4
Blood clot in the leg (DVT)	1.2	1.5	3.8	-1.3	-0.7	-1.9	-0.0
Exposure to tobacco smoke outside home	1.2	1.6	3.5	-1.9	0.3	-1.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.2	1.5	0.4	-0.0	-1.8
Had major operations	1.2	1.4	2.6	0.2	-1.6	1.3	1.2
Osteoporosis (self-reported)	1.2	1.5	3.2	0.7	0.6	-1.4	-1.8
Risk taking	1.2	1.8	4.2	0.0	-0.6	1.6	2.0
Heart disease (siblings)	1.2	1.5	4.9	-0.8	-2.2	-0.6	0.1
Impedance of whole body	1.2	6.0	12.0	1.4	1.5	-3.5	-2.9
Depressed Affect (Nagel 2018)	1.1	2.3	4.1	-1.6	0.6	-2.0	-1.5
Schizophrenia (2018)	1.1	2.3	3.7	1.4	-1.7	1.9	0.8
Medication: Co-codamol	1.1	1.3	3.5	-1.9	0.6	0.4	1.1
Serious illness, injury or assault to yourself	1.1	1.3	2.9	0.3	-1.4	1.7	0.5
Medication: Levothyroxine sodium	1.1	1.9	2.9	-0.4	1.7	-1.4	-1.6
Alcohol intake versus 10 years previously	1.1	1.6	3.1	-1.8	-0.1	-1.7	-0.8
Medication: Lansoprazole	1.1	1.2	2.4	-1.4	-0.4	1.6	0.7
Mean time to correctly identify matches	1.1	2.0	3.6	-0.2	-1.6	1.4	1.9
Chest pain or discomfort	1.1	1.5	2.6	0.7	-1.2	1.3	1.6
Leg pain on walking	1.1	1.4	2.2	-1.1	-0.6	1.5	1.3
Leg fat-free mass (right)	1.1	5.7	10.2	-1.7	-0.7	3.0	3.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.4	-0.5	-1.5	0.9	1.8
Leg predicted mass (right)	1.1	5.8	10.4	-1.7	-0.7	3.1	3.2
Alcohol drinker status: Never	1.1	1.3	2.7	0.1	-0.3	1.6	1.6
Age started oral contraceptive pill	1.1	1.3	3.4	0.3	-0.6	1.2	1.8
Cholesterol lowering medication	1.1	1.6	2.8	0.8	-0.3	-1.6	-1.7
Alcohol drinker status: Previous	1.1	1.3	2.7	-1.6	-0.2	1.2	0.9
Breast Cancer	1.0	2.3	3.4	-1.1	1.3	-1.7	-1.8
Blood Red Count	1.0	9.3	13.0	3.0	-3.6	2.6	2.9
Leg fat-free mass (left)	1.0	5.1	10.2	-1.2	-0.5	3.2	2.9
Medication: Simvastatin	1.0	1.5	3.2	1.8	-0.6	0.6	-1.4
Depression (self-reported)	1.0	1.2	3.3	-0.4	-1.8	-0.1	1.1
Health satisfaction	1.0	1.3	3.5	-1.9	-0.3	0.1	1.3
Mineral and other dietary supplements	1.0	1.3	2.7	-1.5	1.6	0.5	0.2
Medication: Paracetamol	1.0	1.5	2.4	0.7	-1.4	1.5	1.1
Coronary Artery Disease (CAD)	0.9	1.0	3.5	-0.6	0.4	-1.9	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.7	-1.9	0.7	-0.7	-0.6
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.5	1.1	-0.6	0.8	1.2
Qualifications: CSEs or equivalent	0.9	1.2	3.1	-1.8	-1.1	-0.3	-0.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.8	2.0	-0.4	1.9	-0.7
Medication: Atenolol	0.9	1.1	2.2	0.5	-1.5	1.2	0.7
Leg predicted mass (left)	0.9	4.9	10.0	-1.1	-0.5	3.2	2.9
Hearing difficulty/problems with background noise	0.9	1.5	5.8	2.4	0.1	0.2	-0.1
Impedance of arm (left)	0.9	4.0	7.6	0.9	1.5	-2.8	-2.3
Exposure to tobacco smoke at home	0.9	1.0	3.5	0.0	-0.3	-0.8	-1.9
Loud music exposure frequency	0.9	1.0	3.4	0.4	1.9	-0.3	-0.6
Qualifications: College or University degree	0.9	2.9	4.0	1.5	-1.5	2.0	1.7
Supplements: Vitamin C	0.9	1.1	3.2	0.7	-1.8	0.9	0.2
Whole body fat-free mass	0.9	5.0	10.3	-1.1	-0.5	3.2	2.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.7	1.2	1.3	0.9	-0.2
Commuting to job workplace: Walk	0.9	1.0	1.9	1.4	-1.4	-0.3	0.4
Medication: Aspirin	0.9	1.1	1.8	1.2	-1.3	1.0	0.6
Whole body water mass	0.9	4.9	9.9	-1.2	-0.4	3.1	2.9
Medication: Blood pressure	0.9	1.7	5.0	0.9	-2.2	-0.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.8	-1.2	-0.8	-1.7	0.3
Depression (Nagel 2018)	0.8	1.2	4.4	-2.1	0.2	-0.7	-0.1
Mean Putamen Volume	0.8	0.9	1.6	1.0	-0.9	0.2	1.3
Fasting Glucose	0.8	1.0	2.0	-0.3	1.1	-0.8	-1.4
Sensitivity / hurt feelings	0.8	1.3	3.8	-1.9	0.1	0.5	1.1
Medication for hormone replacement therapy	0.8	0.8	1.3	0.9	1.2	-0.7	-0.9
Medication: Metformin	0.8	1.1	1.6	1.0	0.6	1.3	1.2
Number of incorrect matches in round	0.8	1.3	2.7	-1.7	-0.9	0.9	0.9
Had menopause	0.8	0.9	3.2	0.2	1.8	-0.7	-0.1
Impedance of arm (right)	0.8	3.7	7.5	0.8	1.4	-2.7	-2.2
Falls in the last year	0.8	1.1	2.2	0.0	0.6	1.5	1.3
Hair/balding pattern: Pattern 3	0.8	1.2	3.1	-0.5	1.8	-0.7	-1.1
Medication: Aspirin	0.8	1.1	2.6	1.0	-1.6	0.7	0.4
Mood swings	0.8	1.4	3.2	0.1	0.7	-1.4	-1.8
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.5	-0.1	1.2	-1.1	-1.1
Commuting to job workplace: Cycle	0.8	1.0	3.2	0.4	-1.8	-0.7	-0.5
Bipolar Disorder (2018)	0.7	1.1	1.9	-0.1	-1.3	1.0	1.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.3	1.5	-0.8	0.5	-0.1
Blood White Count	0.7	5.0	15.3	3.9	1.6	-1.3	-0.7
Lung FEV1/FVC ratio	0.7	3.8	9.5	3.1	-1.3	-1.3	-1.5
Chronotype (morning person)	0.7	1.6	2.5	1.6	-1.0	1.3	-1.1
Tanning	0.7	8.5	31.1	-5.6	1.2	-1.0	-0.7
Systolic blood pressure, automated reading	0.7	2.0	3.2	0.6	1.7	-1.3	-1.8
Townsend deprivation index at recruitment	0.7	1.0	2.0	1.3	-1.4	0.4	-0.5
Alcohol usually taken with meals	0.7	1.2	3.9	2.0	0.2	-0.6	-0.5
Heart attack	0.7	0.8	2.3	-0.4	0.3	-1.5	-0.9
Asthma	0.7	1.4	2.9	-1.7	0.9	1.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	6.6	1.1	-2.6	0.2	1.1
Trunk predicted mass	0.7	3.9	8.8	-1.0	-0.2	3.0	2.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.5	-0.1	1.6	-0.7	-1.6
Forced vital capacity (FVC), Best measure	0.7	2.4	4.5	0.5	-2.1	0.8	2.0
Leg fat percentage (right)	0.7	2.5	4.7	2.2	2.0	-1.0	-0.5
Worry too long after embarrassment	0.7	1.2	1.7	0.5	-1.2	1.3	1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.9	1.0	1.4	0.0	-0.5
Suffer from ‘nerves’	0.7	1.1	2.0	-0.6	0.8	-1.2	-1.4
Hypertension (Self-reported)	0.7	1.9	5.3	0.4	-1.0	-1.0	-2.3
Asthma (self-reported)	0.7	1.3	2.2	-1.3	0.7	1.5	0.9
Mother’s age at death	0.7	0.9	2.4	1.6	-0.3	-0.1	1.1
Basal metabolic rate	0.7	3.9	8.0	-0.8	-0.1	2.8	2.7
Arm fat-free mass (left)	0.7	3.7	7.2	-0.7	-0.2	2.7	2.7
Number of operations (self-reported)	0.7	1.0	1.6	-0.4	-1.0	1.1	1.3
Fractured/broken bones in last 5 years	0.7	0.9	2.3	-1.5	0.4	-0.6	-0.9
Diastolic blood pressure, automated reading	0.7	2.2	3.9	2.0	-0.2	-1.4	-1.7
Pain experienced in last month	0.7	1.1	2.0	0.1	1.2	-1.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.2	-0.4	0.2	-1.5	-1.0
Arm predicted mass (left)	0.7	3.4	7.1	-0.7	-0.1	2.4	2.7
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	0.2	-1.0	1.3	0.7
Alzheimer’s Disease (including proxy)	0.6	0.9	1.5	0.7	1.2	-1.2	-0.2
Ovarian Cancer	0.6	0.7	1.1	1.0	-0.9	-0.6	-0.8
Ulcerative Colitis	0.6	0.8	1.5	-0.0	-1.2	0.7	1.1
Allergy or Eczema	0.6	1.7	4.1	1.6	0.2	2.0	-0.2
Respiratory disease	0.6	1.3	3.5	-0.2	1.9	0.9	1.0
Hearing difficulty/problems: Yes	0.6	1.0	2.2	1.5	-0.4	1.1	0.5
Diabetes (mother)	0.6	0.7	1.3	1.0	-0.5	0.7	1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.1	-1.4	0.5	-0.3	0.5
High blood pressure	0.6	1.8	4.9	0.6	-0.8	-1.1	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.2	0.2	-1.8	0.5	0.4
Fluid intelligence score	0.6	1.3	3.0	0.4	0.9	-1.7	-1.0
Trunk fat-free mass	0.6	3.7	8.4	-0.9	-0.1	2.9	2.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.6	0.7	-0.4	1.6	1.6
Lung cancer (father)	0.6	0.7	1.7	-0.1	1.3	-1.0	-0.4
Pulse wave reflection index	0.6	0.7	2.3	-1.5	0.0	-0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.6	-1.1	0.8	-0.4	1.3
Medication: Amlodipine	0.6	0.8	2.9	-0.4	-1.7	0.5	-0.1
Birth weight	0.6	1.3	4.9	-2.2	0.1	-0.4	0.2
Arm fat-free mass (right)	0.6	3.2	6.6	-1.0	-0.4	2.6	2.3
Angina (self-reported)	0.6	0.8	1.5	0.6	-1.2	0.1	-1.2
Arm predicted mass (right)	0.6	3.1	6.4	-0.8	-0.2	2.5	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-0.3	-0.4	1.0	1.2
Friendships satisfaction	0.6	0.7	1.4	-1.0	-0.5	0.0	1.2
Osteoarthritis (self-reported)	0.6	0.8	1.2	0.7	0.9	-1.0	-1.1
Wears glasses or contact lenses	0.6	0.7	1.4	1.2	0.6	-0.8	-0.4
Vascular/heart problems diagnosed by doctor	0.6	1.5	3.3	-0.3	1.4	0.8	1.8
Crohns Disease (2017)	0.5	1.2	2.9	-0.3	0.3	-1.2	-1.7
Body Mass Index (BMI) (2010)	0.5	0.7	2.5	0.2	0.5	-1.6	-0.4
Crohns Disease (2012)	0.5	0.8	1.4	-0.7	1.2	-1.1	-0.3
Cardiovascular Disease	0.5	1.8	4.0	0.3	-1.2	-1.3	-2.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.1	0.6	1.1	1.5	0.5
Hand grip strength (left)	0.5	1.3	3.5	-0.5	-0.6	1.0	1.9
Number of treatments/medications taken	0.5	0.9	1.9	0.6	-1.4	1.1	0.4
Angina	0.5	0.7	1.9	0.4	-0.9	0.1	-1.4
Nervous feelings	0.5	0.9	2.9	-0.5	-0.1	-1.7	-0.6
Forced vital capacity (FVC)	0.5	1.9	4.3	0.4	-1.7	0.6	2.1
Diabetes (self-reported)	0.5	0.7	1.4	-0.0	1.2	1.1	0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.9	0.9	-0.3	-0.1	-1.4
Father’s age at death	0.5	0.7	1.7	1.3	-0.2	0.9	-0.3
Worrier / anxious feelings	0.5	1.0	2.1	-1.3	-1.5	-0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	1.0	-1.1	0.1	0.6
Illnesses of mother	0.5	0.6	2.1	-0.5	0.2	-0.3	1.5
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	-1.0	1.0	-1.4	-0.9
High blood pressure (siblings)	0.5	0.7	1.5	-1.2	-0.7	-0.9	-0.4
Body fat percentage	0.5	1.8	3.5	1.8	1.9	-0.6	0.3
Medication for pain relief, constipation, heartburn	0.5	0.8	2.5	-0.4	1.6	-0.4	-0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	-0.5	0.7	-1.2	-0.7
Medication for cholesterol	0.5	0.7	2.5	-0.5	1.6	-0.1	0.4
Guilty feelings	0.5	0.7	1.4	-0.6	-0.9	1.2	0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	-0.6	1.3	0.3	-0.4
High cholesterol (Self-reported)	0.5	0.9	1.9	1.4	-0.9	-0.7	-0.8
Medication: Lisinopril	0.5	0.7	1.9	0.2	-1.4	-0.6	-0.5
Leg fat percentage (left)	0.5	1.9	3.3	1.8	1.8	-1.1	-0.0
Major Depression (MDD)	0.4	0.5	1.1	1.1	0.5	-0.3	-0.8
Smoking Status	0.4	1.0	2.9	-0.4	0.6	-0.7	-1.7
Lung FVC	0.4	2.0	3.9	-1.0	-1.7	0.4	2.0
Neuroticism	0.4	1.0	1.7	-1.3	0.2	-1.2	-0.9
Diabetes (father)	0.4	0.5	1.1	-0.8	0.5	-1.1	0.0
Hand grip strength (right)	0.4	1.2	2.1	0.2	-1.4	0.9	1.3
Age when periods started (menarche)	0.4	1.0	1.6	1.3	-1.1	-1.1	0.3
Stomach or abdominal pain in last month	0.4	0.5	1.3	-0.5	0.5	-1.1	0.2
Waist circumference	0.4	1.6	2.7	-0.3	1.5	1.1	1.6
Had other major operations	0.4	0.4	0.9	-0.9	-0.1	0.5	0.8
Allergy	0.4	0.8	2.9	-0.6	-0.1	-1.7	0.3
Weight	0.4	1.8	3.8	0.2	0.9	1.6	1.9
Number of live births	0.4	0.5	1.6	0.1	1.3	0.5	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.6	1.3	-0.0	0.4	-0.9
Tense / ‘highly strung’	0.4	0.6	1.0	-0.4	-0.8	-0.8	-1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-0.1	0.6	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.3	-0.8	-1.1	0.5	-0.2
Age at first live birth	0.4	0.8	0.9	0.5	-1.0	0.9	1.0
Medication: Blood pressure	0.4	0.7	2.3	0.3	-0.6	-0.1	-1.5
Medication: Omeprazole	0.4	0.4	1.3	-0.3	-1.2	0.4	0.2
Medication: Seretide 50 evohaler	0.4	0.4	1.0	-0.4	-0.7	1.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	1.1	0.6	0.5	-0.6
Loneliness, isolation	0.4	0.5	1.3	-0.6	1.1	-0.6	-0.1
Ever had bowel cancer screening	0.4	0.5	1.0	-0.0	0.4	-0.9	-1.0
Qualifications: nursing, teaching	0.4	0.7	2.4	-0.2	1.5	-0.1	0.4
Average weekly champagne plus white wine intake	0.4	0.6	1.2	-0.1	-0.7	1.1	0.9
Financial situation satisfaction	0.4	0.4	0.9	-0.2	0.4	-1.0	-0.8
Irritability	0.4	0.7	2.6	-1.6	-0.1	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	-0.7	-0.6	0.6	0.9
Neuroticism (Nagel 2018)	0.3	0.7	1.8	-1.3	-0.5	-0.7	-0.4
Ulcerative Colitis (UC)	0.3	0.5	0.9	-0.9	-0.9	-0.4	0.4
Neuroticism (2016)	0.3	0.5	1.7	0.1	-1.3	0.3	-0.1
Triglycerides	0.3	0.5	1.5	-1.2	-0.2	0.5	0.4
Waist Hip Ratio (WHR)	0.3	1.4	3.8	-1.9	0.2	0.2	1.2
Systolic Blood Pressure	0.3	1.6	2.5	-0.2	-1.3	-1.5	-1.6
Hypothyroidism (self reported)	0.3	0.7	1.7	-0.3	1.3	-0.3	-0.9
Average weekly spirits intake	0.3	0.3	0.7	0.1	0.0	-0.8	0.7
Pack years adult smoking proportion	0.3	0.4	1.2	0.6	-0.4	-0.1	-1.1
Trunk fat percentage	0.3	1.3	2.8	1.5	1.7	-0.3	0.5
Maternal smoking around birth	0.3	0.5	1.3	-0.4	-0.7	0.2	1.1
Relative age voice broke	0.3	0.5	0.9	1.0	0.9	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.9	0.2	-0.6	1.4	0.1
Supplements: Glucosamine	0.3	0.4	0.9	0.5	-0.2	-0.7	-1.0
Body mass index (BMI)	0.3	1.1	2.5	0.3	0.9	1.0	1.6
Trunk fat mass	0.3	1.2	2.2	1.0	1.5	0.4	1.1
Financial difficulties in last 2 years	0.3	0.4	1.1	-0.1	-0.7	-0.3	-1.1
Neuroticism score	0.3	0.7	1.9	-1.4	0.1	-0.8	-0.7
Arm fat percentage (right)	0.3	1.2	2.7	1.2	1.6	-0.1	0.8
Hip circumference	0.3	1.2	2.2	0.7	1.5	1.0	1.0
Time employed in main current job	0.3	0.4	0.7	0.1	0.7	0.6	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.6	1.2	-1.3	-0.1	1.0
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	-0.1	0.9	-0.1	-0.9
Prospective memory result	0.3	0.4	0.7	-0.3	-0.8	0.7	0.5
Arm fat mass (right)	0.3	1.4	2.4	0.8	1.4	0.9	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	-0.5	-1.1	-0.4	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	0.3	-1.2	0.2	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.0	0.2	0.8	0.9
Medication: Paracetamol	0.3	0.4	0.8	-0.1	-0.9	0.4	0.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.9	0.4	0.4	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.1	-0.4	1.1	-0.2	0.1
Heart disease (mother)	0.3	0.3	0.8	0.6	-0.2	0.9	-0.3
Whole body fat mass	0.3	1.3	2.7	1.1	1.6	0.3	1.2
Leg fat mass (right)	0.3	1.1	2.2	1.4	1.5	0.2	0.7
Alcohol intake frequency.	0.3	0.7	1.0	-0.5	-0.7	1.0	0.9
Arm fat percentage (left)	0.3	1.0	2.6	1.1	1.6	-0.3	0.6
Diabetes diagnosed by doctor	0.3	0.5	1.7	-0.0	0.6	1.3	0.3
Breast cancer (self-reported)	0.3	0.3	0.6	0.8	-0.4	0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	0.2	-1.0	-1.1	0.4
Arm fat mass (left)	0.3	1.2	2.5	0.7	1.6	0.5	1.2
Hearing aid user	0.3	0.3	0.8	0.9	0.5	0.2	0.4
Average weekly beer plus cider intake	0.3	0.4	0.8	0.9	0.5	-0.5	0.5
Myopia	0.3	0.4	0.8	0.5	-0.9	0.1	-0.8
Supplements: Calcium	0.3	0.3	1.2	0.1	-1.1	-0.1	0.0
Leg fat mass (left)	0.3	1.0	1.8	1.2	1.3	0.2	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.5	-1.1	1.2	0.5	0.2
Worry (Nagel 2018)	0.2	0.4	1.4	-0.2	-1.2	-0.2	-0.0
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	-0.7	-0.2	-0.9	-0.7
HbA1C	0.2	0.2	0.5	0.2	-0.7	0.3	0.3
Height	0.2	4.0	10.8	1.2	-0.1	3.3	2.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.7	-0.7	0.2	-0.4
Current tobacco smoking	0.2	0.4	1.5	-0.0	0.2	0.0	-1.2
Taking other prescription medications	0.2	0.3	0.8	-0.1	0.3	0.9	0.4
Sitting height	0.2	1.5	2.6	0.3	-0.8	1.6	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	0.6	-0.3	0.8	-0.7
Qualifications: None of the above	0.2	0.4	0.8	-0.7	0.2	-0.5	0.9
Medication: Ramipril	0.2	0.3	0.6	-0.4	-0.8	-0.4	-0.4
Headache pain in last month	0.2	0.3	0.7	-0.8	-0.1	-0.8	-0.3
Comparative body size at age 10	0.2	0.6	1.8	-0.1	-0.3	1.4	-0.6
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.0	-0.3	0.9	0.8
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.1	0.7	-0.6	-0.4
Pulse rate, automated reading	0.2	0.6	2.1	0.0	-1.4	-0.1	0.5
Number of full sisters	0.2	0.3	0.4	0.7	0.4	0.2	-0.6
Overall health rating	0.2	0.4	0.8	-0.8	-0.4	-0.9	0.1
Illnesses of siblings: Diabetes	0.2	0.3	0.5	-0.3	-0.5	-0.7	-0.5
Smoking status: Previous	0.2	0.4	0.5	-0.7	0.6	-0.4	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.6	0.3	0.5	0.7
Smoking status: Current	0.2	0.4	1.4	0.2	0.1	0.0	-1.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.5	-0.3	-0.1	-0.0	-1.2
Illnesses of father: High blood pressure	0.2	0.3	1.1	-0.0	-1.1	0.1	-0.1
Pack years of smoking	0.2	0.3	0.7	0.5	-0.3	-0.0	-0.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.1	-0.5	-0.5	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.4	0.7	-0.4	0.1
HDL Cholesterol	0.1	0.2	0.6	0.1	0.1	0.1	0.8
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.1	0.5	0.1	0.3
Heel T-Score	0.1	0.5	1.2	1.1	0.5	0.1	-0.9
BMI	0.1	0.6	1.2	0.1	0.6	0.9	1.1
Hair Pigment	0.1	1.8	3.9	2.0	0.9	1.1	1.1
Relative age of first facial hair	0.1	0.3	0.7	0.4	-0.1	-0.8	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.2	0.1	-0.2	-0.7
Standing height	0.1	1.0	2.2	-0.3	0.3	1.5	1.3
Breastfed as a baby	0.1	0.2	0.6	0.0	0.2	0.8	0.2
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.1	0.1	-0.4	-0.5
Comparative height size at age 10	0.1	0.6	1.5	0.7	0.2	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	0.8	-0.2	0.7	0.1
Average weekly red wine intake	0.1	0.1	0.4	0.6	-0.1	0.2	0.3
Medication: Gliclazide	0.1	0.2	0.3	-0.4	0.4	-0.2	0.6
Ever smoked	0.1	0.1	0.3	0.4	-0.5	0.3	0.0
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.6	0.0	0.1	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Past tobacco smoking	0.0	0.1	0.2	0.1	-0.1	0.0	0.5
Mouth/teeth dental problems	0.0	0.1	0.2	0.0	-0.3	-0.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.1	0.3	-0.2	0.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.2	0.1	0.0	-0.3
Pulse wave peak to peak time	0.0	0.0	0.0	0.2	0.2	-0.1	0.1

Hub : Genes

TRAM2

Models

Trait associations