Hub : Genes

TRAM2-AS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.202 0.0820 0.0094 0.015 NA 0.015 NA 0.018 0.091 NA 0.0940 NA 0.074
2 GTEx Thyroid 0.130 0.0430 0.0010 -0.002 NA 0.019 NA 0.012 0.530 NA 0.0120 NA 0.035
3 METSIM Adipose 0.032 0.0156 0.0120 0.007 0.005 0.017 0.006 0.008 0.024 0.05 0.0012 0.042 0.020

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.1 0.2 0.4 -0.1 0.1
Bipolar Disorder or Schizophrenia 0.6 1.4 2.7 -1.2 -1.6 -0.4
Depressed Affect (Nagel 2018) 0.4 0.8 1.5 0.8 -1.2 -0.3
Depression (Nagel 2018) 0.3 0.4 1.2 0.2 -1.1 -0.2
Intelligence (Savage-Jansen 2018) 0.7 2.2 3.8 1.3 -1.0 -1.9
Neuroticism (Nagel 2018) 0.3 0.7 2.0 0.3 -1.4 -0.2
Schizophrenia (2018) 1.3 2.7 4.2 -1.8 -2.0 -0.7
Schizophrenia vs Biploar Disorder 1.8 2.4 5.8 -1.1 -2.4 0.2
Worry (Nagel 2018) 0.5 1.0 1.7 -0.4 -1.1 1.3
Alzheimer’s Disease (in mother) 1.2 1.4 2.5 -0.7 1.6 1.0
Alzheimer’s Disease (in father) 0.6 0.6 1.1 -0.1 -0.9 -1.1
Alzheimer’s Disease (including proxy) 0.1 0.2 0.5 -0.2 0.7 0.1
Crohns Disease (2017) 1.2 2.6 5.7 2.4 -1.2 0.9
Irritable Bowel Disease (IBD) 0.7 1.8 3.5 1.3 -1.9 0.2
Ulcerative Colitis (UC) 0.8 1.4 3.7 0.6 -1.9 -0.4
Major Depression (MDD) 2.9 3.5 10.3 -0.1 -3.2 0.3
Reaction Time 0.3 0.6 1.1 0.8 1.0 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.3 1.6 1.1 -1.1 -1.3
Breast Cancer 1.0 2.5 5.1 2.3 0.6 1.5
Ovarian Cancer 1.6 2.1 4.6 -1.0 -0.9 2.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.4 0.8 -0.5 0.4 0.9
Bipolar Disorder (2011) 2.2 2.2 5.3 -2.3 1.0 -0.5
Body Mass Index (BMI) (2010) 1.6 2.2 2.9 1.7 1.3 1.4
Coronary Artery Disease (CAD) 1.5 1.8 4.4 2.1 -1.0 -0.1
Crohns Disease (2012) 0.9 1.4 3.7 1.9 0.2 0.8
Mean Putamen Volume 0.4 0.5 0.6 -0.8 0.6 0.6
Fasting Glucose 0.8 0.9 1.9 0.0 -1.4 -0.9
HbA1C 1.0 1.1 1.6 0.5 1.2 1.3
HDL Cholesterol 1.5 2.4 6.2 -0.0 -1.1 2.5
LDL Cholesterol 4.7 7.5 16.9 0.8 4.1 2.2
Lupus 1.1 1.7 2.6 1.2 1.6 1.1
Neuroticism (2016) 0.5 0.7 1.6 0.3 -1.3 0.6
Primary Biliary Cirrhosis 0.2 0.3 0.8 -0.2 0.9 -0.3
Rheumatoid Arthritis 1.0 1.3 2.3 1.3 -0.3 -1.5
Schizophrenia (2014) 1.7 3.7 8.3 -1.6 -2.9 -0.4
Triglycerides 2.3 3.8 7.5 0.5 2.7 -1.9
Type 2 Diabetes (T2D) (2012) 1.7 1.9 5.0 0.6 0.7 2.2
Ulcerative Colitis 0.3 0.5 0.8 0.1 -0.9 0.8
Blood Eosinophil Count 0.3 2.4 4.3 -1.4 1.0 2.1
Blood Platelet Count 2.0 23.1 33.9 5.8 3.5 -4.8
Blood Red Count 1.0 10.1 12.7 -2.3 3.6 3.5
Blood White Count 0.3 2.4 4.3 -0.0 -2.1 1.7
Heel T-Score 0.1 0.9 1.5 -1.0 1.2 0.5
BMI 0.1 0.4 0.8 -0.9 0.1 -0.5
Height 0.1 1.4 2.9 -1.7 0.7 -1.0
Waist Hip Ratio (WHR) 0.3 1.4 2.9 0.9 0.5 1.7
Systolic Blood Pressure 0.2 0.9 1.6 0.9 1.3 0.7
Smoking Status 0.4 1.0 1.2 0.8 -1.0 -1.1
Allergy or Eczema 0.7 1.8 3.5 -1.3 -1.9 0.2
Cardiovascular Disease 0.7 2.3 6.2 -0.7 2.5 0.3
Hypothyroidism (self reported) 0.3 0.8 1.5 0.5 0.8 1.2
Respiratory disease 0.2 0.4 0.7 0.3 -0.8 0.5
Type 2 Diabetes (T2D) (2018) 1.3 2.4 3.5 -1.9 -1.6 1.1
Lung FEV1/FVC ratio 1.8 9.1 20.6 -2.6 -4.5 0.2
Lung FVC 0.5 2.3 6.6 0.2 2.6 -0.6
Neuroticism 0.3 0.6 0.8 -0.6 -0.9 0.8
Chronotype (morning person) 0.4 0.9 2.1 -1.5 -0.5 -0.5
Hair Pigment 0.1 1.7 3.9 -0.7 2.0 0.8
Tanning 0.2 2.5 5.2 2.3 1.1 -1.0
Hand grip strength (left) 0.3 0.9 1.7 1.3 0.4 -0.9
Number of treatments/medications taken 0.2 0.3 0.9 -0.0 0.2 0.9
Average weekly spirits intake 0.6 0.7 1.4 0.8 0.2 -1.2
Sensitivity / hurt feelings 0.5 0.8 2.0 -0.1 -1.4 -0.7
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 -0.5 -0.4 -0.2
Hearing difficulty/problems: Yes 1.1 1.6 3.4 -0.3 -1.8 -1.2
Relative age of first facial hair 0.6 1.2 2.8 0.9 1.7 0.2
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 4.8 0.4 -2.2 0.5
Ever used hormone-replacement therapy (HRT) 0.4 0.6 0.9 0.3 1.0 0.8
Ever had hysterectomy (womb removed) 1.0 1.2 1.9 0.1 1.3 -1.4
Systolic blood pressure, automated reading 0.3 0.7 1.5 0.1 0.8 1.2
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 4.5 -2.1 -0.5 -0.9
Angina 2.8 3.7 7.1 -1.9 -2.7 0.3
Medication for hormone replacement therapy 0.1 0.1 0.4 0.2 0.2 0.6
Vitamin and mineral supplements 0.4 0.5 0.8 0.9 -0.7 -0.6
Supplements: Zinc 0.2 0.3 0.7 0.2 -0.8 0.2
Medication: Co-codamol 0.2 0.3 0.8 0.0 0.9 0.1
Medication: Metformin 0.9 1.3 2.1 -1.5 -1.1 0.8
Diabetes (father) 0.6 0.8 1.1 1.1 1.1 -0.4
Diabetes (mother) 0.9 1.2 2.2 0.0 1.2 1.5
Severe depression (siblings) 1.5 1.7 2.2 1.2 -1.5 1.2
Pack years adult smoking proportion 0.6 0.9 1.4 -1.2 -0.5 1.1
Impedance of leg (right) 0.5 2.5 7.1 0.6 -0.2 2.7
Leg fat-free mass (left) 0.2 0.9 1.8 -0.8 -0.1 -1.4
Trunk fat percentage 0.5 2.1 4.5 -1.3 -2.1 0.4
Hand grip strength (right) 0.0 0.1 0.1 -0.4 -0.2 -0.2
Townsend deprivation index at recruitment 1.3 1.9 5.0 -2.2 -0.2 -0.8
Current tobacco smoking 0.2 0.4 0.9 0.0 -0.4 1.0
Average weekly fortified wine intake 2.2 2.5 7.2 -0.6 2.7 0.3
Maternal smoking around birth 0.1 0.2 0.5 0.3 -0.0 0.7
Fed-up feelings 0.2 0.4 0.7 0.5 -0.9 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 4.1 1.1 -2.0 -0.2
Relative age voice broke 0.1 0.2 0.2 -0.4 -0.5 -0.1
Taking other prescription medications 1.0 1.5 2.1 -1.1 -1.1 1.5
Age when periods started (menarche) 1.0 2.3 3.4 1.3 -1.4 1.8
Bilateral oophorectomy (both ovaries removed) 1.9 2.3 4.3 1.5 2.1 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.6 -0.8 0.6 -0.7
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.3 -0.4 1.8 0.6
Qualifications: CSEs or equivalent 1.5 2.0 4.0 1.2 0.7 -2.0
Serious illness, injury or assault to yourself 1.2 1.5 3.1 -1.1 1.8 0.2
High blood pressure 0.3 0.7 1.1 -0.8 1.1 0.6
Hayfever, allergic rhinitis or eczema 1.2 2.7 6.7 -0.8 -2.6 0.8
Multivitamins +/- minerals 0.2 0.2 0.5 -0.7 0.4 -0.0
Stomach or abdominal pain in last month 0.1 0.1 0.3 -0.3 0.5 0.3
Supplements: Glucosamine 0.1 0.1 0.2 0.0 -0.4 0.3
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.0 0.7 -0.5 -1.4
Medication: Atenolol 1.9 2.3 3.8 -0.5 1.9 1.7
Medication: Levothyroxine sodium 0.3 0.6 1.0 0.8 1.0 -0.1
Sitting height 0.0 0.3 0.7 -0.9 -0.2 -0.2
Chronic bronchitis/emphysema (father) 1.2 1.4 2.8 -0.9 1.7 0.7
High blood pressure (mother) 0.1 0.1 0.4 0.6 -0.1 0.2
Body mass index (BMI) 0.1 0.5 1.3 -1.2 -0.3 0.2
Impedance of leg (left) 0.2 1.0 2.8 0.2 -0.2 1.7
Leg predicted mass (left) 0.2 0.8 1.6 -0.9 -0.1 -1.3
Trunk fat mass 0.3 1.4 2.2 -1.3 -1.5 0.3
Waist circumference 0.3 1.3 2.0 -1.4 -1.0 -0.8
Number of incorrect matches in round 0.3 0.5 1.1 0.5 1.1 -0.5
Past tobacco smoking 1.3 2.4 6.5 -0.1 0.8 2.5
Alcohol usually taken with meals 1.2 1.9 2.8 -0.8 1.7 1.5
Nervous feelings 0.4 0.8 2.2 0.1 -0.3 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 -0.5 0.2 1.0
Hearing difficulty/problems with background noise 0.7 1.1 1.8 -1.4 -0.8 -0.9
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 0.3 -0.2 0.5
Had menopause 1.4 1.7 5.2 -0.0 -0.1 2.3
Had other major operations 0.2 0.2 0.3 0.3 0.6 0.5
Forced vital capacity (FVC) 0.1 0.2 0.5 -0.3 0.1 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.9 -2.0 0.6 -0.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.8 0.1 -1.7 0.6
Qualifications: None of the above 0.4 0.9 1.5 -1.0 0.5 1.2
Financial difficulties in last 2 years 1.5 2.0 4.2 0.5 -1.3 -2.1
Mouth/teeth dental problems 0.3 0.5 0.8 0.9 0.2 -0.8
Heart attack 0.3 0.3 0.9 -0.3 -0.0 0.9
Allergy 0.8 1.8 3.8 -0.2 2.0 -1.3
Pain all over the body in last month 0.6 0.7 1.6 -0.4 0.4 1.3
Diabetes (self-reported) 1.0 1.6 2.7 -1.4 -1.6 -0.4
Hayfever/allergic rhinitis (self-reported) 3.5 4.6 13.3 0.8 -3.7 0.1
Medication: Ramipril 0.1 0.1 0.2 -0.5 -0.1 -0.1
Medication: Simvastatin 0.4 0.6 1.0 -0.8 1.0 0.3
Fluid intelligence score 0.6 1.2 2.3 1.5 -1.2 -0.1
Illnesses of siblings 0.4 0.6 1.4 0.1 -1.2 -0.7
Neuroticism score 0.7 1.4 3.7 -0.5 -1.9 0.4
Weight 0.2 0.8 1.9 -1.4 -0.5 -0.3
Impedance of arm (right) 0.7 3.2 6.7 0.9 -2.6 -1.5
Arm fat percentage (right) 0.3 1.3 2.8 -1.1 -1.7 -0.1
Trunk fat-free mass 0.2 0.9 1.7 -0.6 1.3 -0.7
Hip circumference 0.8 3.4 4.5 -1.6 -2.1 -1.8
Time employed in main current job 0.4 0.5 0.7 -0.5 0.8 -0.8
Alcohol intake versus 10 years previously 0.4 0.6 1.3 0.0 0.7 1.1
Father’s age at death 0.2 0.2 0.3 0.3 -0.5 0.5
Worrier / anxious feelings 0.6 1.1 1.5 0.8 -1.1 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.5 -1.0 -0.8 -1.2
Falls in the last year 1.8 2.5 4.0 -2.0 1.5 1.1
Hair/balding pattern: Pattern 3 1.4 2.0 4.5 -0.4 -1.2 -2.1
Number of live births 0.2 0.3 0.7 -0.8 -0.3 0.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 0.9 -0.6 -0.5 -0.9
Pulse rate 0.6 1.0 1.6 -1.2 -0.0 1.3
Happiness 1.0 1.2 2.4 1.6 0.4 1.0
Noisy workplace 2.0 2.5 5.3 0.5 1.3 2.3
Qualifications: A levels/AS levels or equivalent 1.2 2.6 5.9 -1.0 -0.9 -2.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.2 -1.1 -1.0 -0.3
Mouth/teeth dental problems: Dentures 0.3 0.5 0.6 -0.7 0.8 0.7
Asthma 0.3 0.5 0.9 0.9 -0.8 0.3
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 1.9 1.1 -0.9 1.4
Medication: Cholesterol lowering 1.2 1.8 2.2 -1.2 1.3 1.5
Depression (self-reported) 0.6 0.7 1.1 -0.8 -1.0 0.7
Medication: Lansoprazole 0.1 0.2 0.5 -0.1 -0.7 0.1
Prospective memory result 0.5 0.6 1.1 1.0 0.8 -0.3
Lung cancer (father) 0.1 0.1 0.1 -0.2 -0.3 0.4
Illnesses of mother 0.7 0.8 2.2 0.5 1.5 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 0.7 -0.5 -0.8 -0.8
Pulse wave Arterial Stiffness index 0.3 0.4 0.9 -0.4 -0.1 -0.9
Impedance of arm (left) 0.8 3.5 8.7 0.4 -3.0 -1.3
Arm fat mass (right) 0.2 0.8 1.6 -1.3 -0.9 -0.1
Trunk predicted mass 0.2 1.0 1.9 -0.6 1.4 -0.8
Standing height 0.1 0.6 1.7 -0.4 -0.2 -1.3
Length of working week for main job 1.6 1.7 2.8 -1.7 1.0 -1.2
Exposure to tobacco smoke at home 0.3 0.4 0.9 0.9 -0.2 0.4
Breastfed as a baby 0.5 0.6 1.4 -0.5 1.2 -0.3
Tense / ‘highly strung’ 1.5 2.5 7.0 0.4 -2.7 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 3.8 5.8 15.0 0.8 -3.9 -1.3
Hair/balding pattern: Pattern 4 1.0 2.5 3.6 1.9 -1.5 -1.3
Birth weight of first child 0.3 0.6 1.8 -1.3 -0.0 0.1
Peak expiratory flow (PEF) 0.0 0.1 0.3 0.1 -0.5 0.1
Pulse wave reflection index 0.3 0.4 0.7 0.8 0.2 -0.6
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.2 -0.6 -1.5 0.0
Loud music exposure frequency 0.1 0.1 0.3 0.6 -0.1 0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.0 0.3 1.0 -0.3
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 -0.5 -0.2 -0.3
Blood clot in the leg (DVT) 0.3 0.4 1.2 1.1 0.0 0.2
Medication: Paracetamol 0.4 0.7 1.3 0.4 -0.7 1.1
Headache pain in last month 0.0 0.0 0.1 0.3 -0.2 0.2
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 3.1 0.9 -1.8 -1.3
Glaucoma (self-reported) 1.5 1.7 3.1 1.0 -1.0 -1.8
Gout (self-reported) 0.4 0.6 0.9 1.0 -0.6 -0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.2 0.4 0.3 0.4
Medication: Amlodipine 0.1 0.1 0.3 0.5 -0.1 0.2
Medication: Ventolin 100micrograms inhaler 0.7 1.0 1.9 0.8 -0.5 1.4
Birth weight 0.9 2.0 2.8 1.1 1.7 -1.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.4 -0.6 0.2 -0.5
High blood pressure (siblings) 0.2 0.3 0.9 0.3 0.9 0.3
Forced vital capacity (FVC), Best measure 0.1 0.3 0.9 -0.3 0.1 -0.9
Body fat percentage 0.5 1.9 3.0 -1.4 -1.7 0.9
Leg fat percentage (right) 0.6 2.1 4.9 -1.1 -0.5 2.2
Arm fat-free mass (right) 0.2 0.9 1.8 -0.9 1.3 0.3
Exposure to tobacco smoke outside home 0.6 0.8 1.7 0.0 0.8 -1.3
Comparative body size at age 10 0.3 0.9 2.2 -1.5 0.6 -0.5
Number of full brothers 3.1 3.8 6.8 1.9 2.6 1.0
Worry too long after embarrassment 0.3 0.6 0.9 -0.9 -0.9 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 6.3 -1.4 -2.5 -1.0
Wheeze or whistling in the chest in last year 0.6 1.0 2.7 -0.4 0.3 1.6
Number of children fathered 0.3 0.4 0.7 0.6 0.8 0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.6 4.3 0.5 -2.1 -0.3
Age at first live birth 0.2 0.4 0.8 0.6 -0.9 -0.4
Pulse wave peak to peak time 0.3 0.4 1.0 0.5 0.0 1.0
Health satisfaction 0.5 0.6 1.4 0.7 0.2 1.2
Shortness of breath walking on level ground 0.8 1.0 2.0 -0.6 -0.8 1.4
Qualifications: College or University degree 0.3 0.9 1.9 -1.4 -0.6 -0.7
Eye problems/disorders: None of the above 0.7 0.8 2.1 1.4 0.3 0.4
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.7 -0.5 1.3 -0.5
Emphysema/chronic bronchitis 1.6 1.8 5.2 0.6 0.1 2.3
Medication for pain relief, constipation, heartburn 0.6 1.0 2.1 -0.6 1.4 -0.9
Neck or shoulder pain in last month 0.3 0.5 0.6 -0.8 -0.6 0.7
Medication: Blood pressure 0.7 1.2 2.3 -0.3 1.5 1.0
Angina (self-reported) 2.7 3.6 6.7 -1.9 -2.6 0.6
Migraine (self-reported) 2.6 3.3 6.1 -1.5 1.3 2.5
Medication: Ibuprofen 1.4 1.7 4.6 0.2 -0.6 2.2
Medication: Allopurinol 0.7 1.0 1.7 1.0 -0.3 -1.3
Medication: Omeprazole 0.8 1.0 2.3 -0.7 -1.5 -0.5
Medication: Seretide 50 evohaler 0.1 0.1 0.1 -0.0 -0.4 0.2
Mean time to correctly identify matches 0.1 0.3 0.5 -0.2 0.7 0.5
Heart disease (mother) 3.1 3.8 5.3 -1.0 -2.3 -2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.8 4.6 12.5 0.1 3.5 1.1
Whole body fat mass 0.3 1.4 2.2 -1.5 -1.3 0.5
Leg fat mass (right) 0.3 1.3 2.1 -1.2 -0.4 1.4
Arm predicted mass (right) 0.2 1.2 2.5 -1.1 1.6 0.2
Pulse rate, automated reading 0.4 1.3 3.3 -0.5 -0.6 1.8
Alcohol intake frequency. 0.1 0.2 0.4 -0.6 -0.4 0.0
Comparative height size at age 10 0.2 1.2 3.0 -1.7 -0.4 -0.7
Number of full sisters 2.1 2.6 3.2 -1.7 -1.3 -1.8
Suffer from ‘nerves’ 1.5 2.3 6.4 -0.7 -2.5 0.2
Overall health rating 1.0 2.1 6.1 0.2 -0.2 2.5
Chest pain or discomfort 1.1 1.6 2.3 -1.5 -1.5 0.7
Had major operations 0.1 0.2 0.3 0.4 -0.6 -0.2
Age at last live birth 0.3 0.5 0.7 -0.5 -0.9 -0.6
Family relationship satisfaction 1.2 1.5 2.8 1.7 0.5 1.1
Leg pain on walking 0.6 0.8 1.7 -0.3 -0.8 1.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.0 -0.5 -1.0 -0.0
Commuting to job workplace: Car/motor vehicle 1.4 1.7 3.0 -0.2 -1.4 -1.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 0.6 0.7 0.4 0.8
Medication: Aspirin 1.2 1.5 4.4 -0.5 -2.1 0.0
Supplements: Vitamin C 1.1 1.3 3.6 0.3 0.6 1.9
Knee pain experienced in last month 0.7 1.1 1.6 -1.3 -1.0 0.8
Hypertension (Self-reported) 0.2 0.6 1.1 -0.7 1.1 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.1 -0.2 1.4 0.9
Illnesses of father: Heart disease 1.1 1.5 3.8 0.5 0.6 -2.0
Illnesses of siblings: Diabetes 0.5 0.7 1.0 1.0 0.1 1.0
Smoking status: Previous 3.5 5.2 13.2 0.3 -1.5 -3.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.3 -0.2 -0.3 -1.1
Whole body fat-free mass 0.1 0.8 0.8 -0.8 0.9 -0.9
Leg fat-free mass (right) 0.3 1.7 4.2 -0.9 -0.0 -2.1
Arm fat percentage (left) 0.4 1.8 4.2 -1.1 -2.0 -0.1
Average weekly red wine intake 1.1 1.7 3.2 -1.2 1.8 0.5
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.4 0.6 0.3 -0.6
Mood swings 0.2 0.4 1.2 0.2 -1.1 0.2
Loneliness, isolation 0.5 0.7 1.6 -0.3 -0.6 -1.3
Long-standing illness, disability or infirmity 0.5 0.7 1.1 -1.0 -0.4 1.1
Ever had bowel cancer screening 1.7 1.9 5.3 0.5 -2.3 -0.5
Diabetes diagnosed by doctor 1.3 2.1 4.7 -1.2 -2.2 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 0.1 -0.2 -0.2
Friendships satisfaction 0.7 0.9 2.4 0.2 1.5 0.5
Qualifications: nursing, teaching 0.3 0.5 0.8 -0.2 -0.9 -0.8
Commuting to job workplace: Walk 1.3 1.4 3.5 -0.6 0.5 1.9
Eye problems/disorders: Cataract 3.2 3.7 4.5 -2.0 -1.6 -2.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.9 0.3 -0.9 -0.4
Medication for cholesterol 0.3 0.4 0.8 0.6 -0.2 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.1 -1.1 -0.5 1.5
Back pain experienced in last month 1.5 2.2 4.8 -2.2 -0.7 -1.2
Mineral and other dietary supplements 0.6 0.8 1.8 0.7 1.4 -0.1
Breast cancer (self-reported) 0.1 0.1 0.2 0.4 0.4 -0.2
Asthma (self-reported) 0.2 0.3 0.5 0.6 -0.7 0.4
Osteoporosis (self-reported) 0.4 0.5 1.3 0.4 1.1 0.0
Osteoarthritis (self-reported) 0.5 0.7 1.2 -1.1 -0.5 0.7
Medication: Aspirin 0.8 1.0 2.8 -0.5 -1.7 -0.0
Medication: Gliclazide 0.5 0.5 1.0 -1.0 -0.0 0.8
Illnesses of father: None of the above (group 1) 0.5 0.7 1.0 -0.4 -1.0 0.9
Smoking status: Current 0.3 0.5 1.4 -0.0 -0.1 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.7 0.8 0.1 -0.6
Whole body water mass 0.1 0.7 0.8 -0.7 0.9 -0.9
Leg predicted mass (right) 0.3 1.6 4.1 -0.8 -0.1 -2.0
Arm fat mass (left) 0.3 1.1 1.6 -1.3 -1.2 -0.1
Number of self-reported non-cancer illnesses 0.5 0.9 1.8 -0.0 -1.4 -0.9
Average weekly champagne plus white wine intake 0.5 0.6 0.9 1.0 -0.5 -0.8
Miserableness 0.8 1.3 2.0 1.4 -1.3 -0.6
Guilty feelings 2.0 2.9 6.3 -2.5 -1.4 -0.7
Wears glasses or contact lenses 0.6 0.7 1.6 -1.3 -0.6 0.2
Ever taken oral contraceptive pill 0.4 0.4 0.6 0.3 -0.8 0.8
Hearing aid user 1.1 1.3 1.9 -0.9 1.1 1.4
Mother’s age at death 0.3 0.3 0.9 0.1 0.3 1.0
Financial situation satisfaction 0.2 0.2 0.6 0.8 -0.1 -0.3
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.2 0.1 0.8 -1.5
Commuting to job workplace: Public transport 0.6 0.7 1.5 -0.5 0.7 1.2
Eye problems/disorders: Glaucoma 1.0 1.2 3.0 1.7 0.6 -0.3
Medication: Blood pressure 0.9 1.6 2.9 -1.7 -0.2 1.4
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.2 -1.5 0.7 -0.1
Supplements: Fish oil (including cod liver oil) 1.3 1.7 4.4 -0.9 -2.1 0.2
High cholesterol (Self-reported) 3.2 5.7 13.1 -1.4 3.6 1.5
Medication: Bendroflumethiazide 0.5 0.7 0.9 -0.7 0.9 0.9
Medication: Paracetamol 0.6 0.9 2.0 -0.7 -1.4 0.4
Medication: Lisinopril 0.8 1.0 2.5 0.4 -1.6 -0.7
Medication: Atorvastatin 0.3 0.3 0.6 -0.4 -0.8 0.5
Illnesses of father: High blood pressure 0.4 0.5 0.8 0.9 -0.5 -0.7
Alcohol drinker status: Never 0.7 0.8 2.2 -0.4 1.5 0.3
Ever smoked 0.6 1.1 3.0 -0.4 -0.4 -1.7
Basal metabolic rate 0.1 0.6 0.9 -0.9 0.5 -0.9
Leg fat percentage (left) 0.3 1.3 1.8 -1.3 -0.4 1.3
Arm fat-free mass (left) 0.2 1.1 2.6 -0.8 1.6 0.2
Number of operations (self-reported) 0.2 0.3 0.6 0.8 0.3 0.3
Average weekly beer plus cider intake 0.2 0.2 0.5 -0.7 -0.5 -0.2
Irritability 0.3 0.5 0.6 0.7 -0.7 -0.8
Risk taking 0.9 1.3 2.3 -1.5 -0.7 1.1
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.5 -0.5 -1.2 -1.2
Fractured/broken bones in last 5 years 0.6 0.8 1.4 0.2 -1.0 -1.2
Age started oral contraceptive pill 2.0 2.5 5.6 -0.7 1.1 2.4
Diastolic blood pressure, automated reading 0.1 0.3 0.5 -0.7 -0.1 0.7
Ever depressed for a whole week 1.6 2.0 3.7 -0.8 -1.3 1.9
Unable to work because of sickness or disability 0.5 0.6 1.4 -0.6 -1.2 -0.2
Commuting to job workplace: Cycle 0.2 0.3 0.4 -0.1 0.7 0.6
Myopia 1.3 1.9 5.2 0.0 -0.6 -2.3
Vascular/heart problems diagnosed by doctor 0.5 1.3 1.8 1.1 -1.0 -1.3
Cholesterol lowering medication 0.0 0.0 0.0 0.0 0.2 0.0
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 5.9 -0.8 -2.4 -0.7
Pain experienced in last month 0.3 0.5 0.7 0.8 0.1 -0.8
Supplements: Calcium 0.3 0.3 0.7 0.9 -0.4 -0.1
Basal cell carcinoma (self-reported) 0.2 0.3 0.4 0.7 0.5 -0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.3 -0.1 0.2 1.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.0 1.0 0.2 0.1
Heart disease (siblings) 0.3 0.3 0.6 0.8 0.6 -0.3
Alcohol drinker status: Previous 1.6 1.8 4.5 2.1 -0.4 -0.9
Pack years of smoking 0.8 1.2 2.3 -1.5 -0.3 1.1
Impedance of whole body 0.2 0.8 2.2 0.5 -1.5 0.3
Leg fat mass (left) 0.2 0.9 1.8 -1.3 -0.4 0.9
Arm predicted mass (left) 0.2 1.2 2.6 -0.9 1.6 0.3