Hub : Genes

TRAM2-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.202	0.0820	0.0094	0.015	NA	0.015	NA	0.018	0.091	NA	0.0940	NA	0.074
2	GTEx	Thyroid	0.130	0.0430	0.0010	-0.002	NA	0.019	NA	0.012	0.530	NA	0.0120	NA	0.035
3	METSIM	Adipose	0.032	0.0156	0.0120	0.007	0.005	0.017	0.006	0.008	0.024	0.05	0.0012	0.042	0.020

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.1	0.2	0.4	-0.1	0.1
Bipolar Disorder or Schizophrenia	0.6	1.4	2.7	-1.2	-1.6	-0.4
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	0.8	-1.2	-0.3
Depression (Nagel 2018)	0.3	0.4	1.2	0.2	-1.1	-0.2
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.8	1.3	-1.0	-1.9
Neuroticism (Nagel 2018)	0.3	0.7	2.0	0.3	-1.4	-0.2
Schizophrenia (2018)	1.3	2.7	4.2	-1.8	-2.0	-0.7
Schizophrenia vs Biploar Disorder	1.8	2.4	5.8	-1.1	-2.4	0.2
Worry (Nagel 2018)	0.5	1.0	1.7	-0.4	-1.1	1.3
Alzheimer’s Disease (in mother)	1.2	1.4	2.5	-0.7	1.6	1.0
Alzheimer’s Disease (in father)	0.6	0.6	1.1	-0.1	-0.9	-1.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	-0.2	0.7	0.1
Crohns Disease (2017)	1.2	2.6	5.7	2.4	-1.2	0.9
Irritable Bowel Disease (IBD)	0.7	1.8	3.5	1.3	-1.9	0.2
Ulcerative Colitis (UC)	0.8	1.4	3.7	0.6	-1.9	-0.4
Major Depression (MDD)	2.9	3.5	10.3	-0.1	-3.2	0.3
Reaction Time	0.3	0.6	1.1	0.8	1.0	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	1.6	1.1	-1.1	-1.3
Breast Cancer	1.0	2.5	5.1	2.3	0.6	1.5
Ovarian Cancer	1.6	2.1	4.6	-1.0	-0.9	2.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	0.8	-0.5	0.4	0.9
Bipolar Disorder (2011)	2.2	2.2	5.3	-2.3	1.0	-0.5
Body Mass Index (BMI) (2010)	1.6	2.2	2.9	1.7	1.3	1.4
Coronary Artery Disease (CAD)	1.5	1.8	4.4	2.1	-1.0	-0.1
Crohns Disease (2012)	0.9	1.4	3.7	1.9	0.2	0.8
Mean Putamen Volume	0.4	0.5	0.6	-0.8	0.6	0.6
Fasting Glucose	0.8	0.9	1.9	0.0	-1.4	-0.9
HbA1C	1.0	1.1	1.6	0.5	1.2	1.3
HDL Cholesterol	1.5	2.4	6.2	-0.0	-1.1	2.5
LDL Cholesterol	4.7	7.5	16.9	0.8	4.1	2.2
Lupus	1.1	1.7	2.6	1.2	1.6	1.1
Neuroticism (2016)	0.5	0.7	1.6	0.3	-1.3	0.6
Primary Biliary Cirrhosis	0.2	0.3	0.8	-0.2	0.9	-0.3
Rheumatoid Arthritis	1.0	1.3	2.3	1.3	-0.3	-1.5
Schizophrenia (2014)	1.7	3.7	8.3	-1.6	-2.9	-0.4
Triglycerides	2.3	3.8	7.5	0.5	2.7	-1.9
Type 2 Diabetes (T2D) (2012)	1.7	1.9	5.0	0.6	0.7	2.2
Ulcerative Colitis	0.3	0.5	0.8	0.1	-0.9	0.8
Blood Eosinophil Count	0.3	2.4	4.3	-1.4	1.0	2.1
Blood Platelet Count	2.0	23.1	33.9	5.8	3.5	-4.8
Blood Red Count	1.0	10.1	12.7	-2.3	3.6	3.5
Blood White Count	0.3	2.4	4.3	-0.0	-2.1	1.7
Heel T-Score	0.1	0.9	1.5	-1.0	1.2	0.5
BMI	0.1	0.4	0.8	-0.9	0.1	-0.5
Height	0.1	1.4	2.9	-1.7	0.7	-1.0
Waist Hip Ratio (WHR)	0.3	1.4	2.9	0.9	0.5	1.7
Systolic Blood Pressure	0.2	0.9	1.6	0.9	1.3	0.7
Smoking Status	0.4	1.0	1.2	0.8	-1.0	-1.1
Allergy or Eczema	0.7	1.8	3.5	-1.3	-1.9	0.2
Cardiovascular Disease	0.7	2.3	6.2	-0.7	2.5	0.3
Hypothyroidism (self reported)	0.3	0.8	1.5	0.5	0.8	1.2
Respiratory disease	0.2	0.4	0.7	0.3	-0.8	0.5
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.5	-1.9	-1.6	1.1
Lung FEV1/FVC ratio	1.8	9.1	20.6	-2.6	-4.5	0.2
Lung FVC	0.5	2.3	6.6	0.2	2.6	-0.6
Neuroticism	0.3	0.6	0.8	-0.6	-0.9	0.8
Chronotype (morning person)	0.4	0.9	2.1	-1.5	-0.5	-0.5
Hair Pigment	0.1	1.7	3.9	-0.7	2.0	0.8
Tanning	0.2	2.5	5.2	2.3	1.1	-1.0
Hand grip strength (left)	0.3	0.9	1.7	1.3	0.4	-0.9
Number of treatments/medications taken	0.2	0.3	0.9	-0.0	0.2	0.9
Average weekly spirits intake	0.6	0.7	1.4	0.8	0.2	-1.2
Sensitivity / hurt feelings	0.5	0.8	2.0	-0.1	-1.4	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.5	-0.4	-0.2
Hearing difficulty/problems: Yes	1.1	1.6	3.4	-0.3	-1.8	-1.2
Relative age of first facial hair	0.6	1.2	2.8	0.9	1.7	0.2
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.8	0.4	-2.2	0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.6	0.9	0.3	1.0	0.8
Ever had hysterectomy (womb removed)	1.0	1.2	1.9	0.1	1.3	-1.4
Systolic blood pressure, automated reading	0.3	0.7	1.5	0.1	0.8	1.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.5	-2.1	-0.5	-0.9
Angina	2.8	3.7	7.1	-1.9	-2.7	0.3
Medication for hormone replacement therapy	0.1	0.1	0.4	0.2	0.2	0.6
Vitamin and mineral supplements	0.4	0.5	0.8	0.9	-0.7	-0.6
Supplements: Zinc	0.2	0.3	0.7	0.2	-0.8	0.2
Medication: Co-codamol	0.2	0.3	0.8	0.0	0.9	0.1
Medication: Metformin	0.9	1.3	2.1	-1.5	-1.1	0.8
Diabetes (father)	0.6	0.8	1.1	1.1	1.1	-0.4
Diabetes (mother)	0.9	1.2	2.2	0.0	1.2	1.5
Severe depression (siblings)	1.5	1.7	2.2	1.2	-1.5	1.2
Pack years adult smoking proportion	0.6	0.9	1.4	-1.2	-0.5	1.1
Impedance of leg (right)	0.5	2.5	7.1	0.6	-0.2	2.7
Leg fat-free mass (left)	0.2	0.9	1.8	-0.8	-0.1	-1.4
Trunk fat percentage	0.5	2.1	4.5	-1.3	-2.1	0.4
Hand grip strength (right)	0.0	0.1	0.1	-0.4	-0.2	-0.2
Townsend deprivation index at recruitment	1.3	1.9	5.0	-2.2	-0.2	-0.8
Current tobacco smoking	0.2	0.4	0.9	0.0	-0.4	1.0
Average weekly fortified wine intake	2.2	2.5	7.2	-0.6	2.7	0.3
Maternal smoking around birth	0.1	0.2	0.5	0.3	-0.0	0.7
Fed-up feelings	0.2	0.4	0.7	0.5	-0.9	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.1	1.1	-2.0	-0.2
Relative age voice broke	0.1	0.2	0.2	-0.4	-0.5	-0.1
Taking other prescription medications	1.0	1.5	2.1	-1.1	-1.1	1.5
Age when periods started (menarche)	1.0	2.3	3.4	1.3	-1.4	1.8
Bilateral oophorectomy (both ovaries removed)	1.9	2.3	4.3	1.5	2.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.6	-0.8	0.6	-0.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.3	-0.4	1.8	0.6
Qualifications: CSEs or equivalent	1.5	2.0	4.0	1.2	0.7	-2.0
Serious illness, injury or assault to yourself	1.2	1.5	3.1	-1.1	1.8	0.2
High blood pressure	0.3	0.7	1.1	-0.8	1.1	0.6
Hayfever, allergic rhinitis or eczema	1.2	2.7	6.7	-0.8	-2.6	0.8
Multivitamins +/- minerals	0.2	0.2	0.5	-0.7	0.4	-0.0
Stomach or abdominal pain in last month	0.1	0.1	0.3	-0.3	0.5	0.3
Supplements: Glucosamine	0.1	0.1	0.2	0.0	-0.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.0	0.7	-0.5	-1.4
Medication: Atenolol	1.9	2.3	3.8	-0.5	1.9	1.7
Medication: Levothyroxine sodium	0.3	0.6	1.0	0.8	1.0	-0.1
Sitting height	0.0	0.3	0.7	-0.9	-0.2	-0.2
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	-0.9	1.7	0.7
High blood pressure (mother)	0.1	0.1	0.4	0.6	-0.1	0.2
Body mass index (BMI)	0.1	0.5	1.3	-1.2	-0.3	0.2
Impedance of leg (left)	0.2	1.0	2.8	0.2	-0.2	1.7
Leg predicted mass (left)	0.2	0.8	1.6	-0.9	-0.1	-1.3
Trunk fat mass	0.3	1.4	2.2	-1.3	-1.5	0.3
Waist circumference	0.3	1.3	2.0	-1.4	-1.0	-0.8
Number of incorrect matches in round	0.3	0.5	1.1	0.5	1.1	-0.5
Past tobacco smoking	1.3	2.4	6.5	-0.1	0.8	2.5
Alcohol usually taken with meals	1.2	1.9	2.8	-0.8	1.7	1.5
Nervous feelings	0.4	0.8	2.2	0.1	-0.3	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.5	0.2	1.0
Hearing difficulty/problems with background noise	0.7	1.1	1.8	-1.4	-0.8	-0.9
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.3	-0.2	0.5
Had menopause	1.4	1.7	5.2	-0.0	-0.1	2.3
Had other major operations	0.2	0.2	0.3	0.3	0.6	0.5
Forced vital capacity (FVC)	0.1	0.2	0.5	-0.3	0.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.9	-2.0	0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.8	0.1	-1.7	0.6
Qualifications: None of the above	0.4	0.9	1.5	-1.0	0.5	1.2
Financial difficulties in last 2 years	1.5	2.0	4.2	0.5	-1.3	-2.1
Mouth/teeth dental problems	0.3	0.5	0.8	0.9	0.2	-0.8
Heart attack	0.3	0.3	0.9	-0.3	-0.0	0.9
Allergy	0.8	1.8	3.8	-0.2	2.0	-1.3
Pain all over the body in last month	0.6	0.7	1.6	-0.4	0.4	1.3
Diabetes (self-reported)	1.0	1.6	2.7	-1.4	-1.6	-0.4
Hayfever/allergic rhinitis (self-reported)	3.5	4.6	13.3	0.8	-3.7	0.1
Medication: Ramipril	0.1	0.1	0.2	-0.5	-0.1	-0.1
Medication: Simvastatin	0.4	0.6	1.0	-0.8	1.0	0.3
Fluid intelligence score	0.6	1.2	2.3	1.5	-1.2	-0.1
Illnesses of siblings	0.4	0.6	1.4	0.1	-1.2	-0.7
Neuroticism score	0.7	1.4	3.7	-0.5	-1.9	0.4
Weight	0.2	0.8	1.9	-1.4	-0.5	-0.3
Impedance of arm (right)	0.7	3.2	6.7	0.9	-2.6	-1.5
Arm fat percentage (right)	0.3	1.3	2.8	-1.1	-1.7	-0.1
Trunk fat-free mass	0.2	0.9	1.7	-0.6	1.3	-0.7
Hip circumference	0.8	3.4	4.5	-1.6	-2.1	-1.8
Time employed in main current job	0.4	0.5	0.7	-0.5	0.8	-0.8
Alcohol intake versus 10 years previously	0.4	0.6	1.3	0.0	0.7	1.1
Father’s age at death	0.2	0.2	0.3	0.3	-0.5	0.5
Worrier / anxious feelings	0.6	1.1	1.5	0.8	-1.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.5	-1.0	-0.8	-1.2
Falls in the last year	1.8	2.5	4.0	-2.0	1.5	1.1
Hair/balding pattern: Pattern 3	1.4	2.0	4.5	-0.4	-1.2	-2.1
Number of live births	0.2	0.3	0.7	-0.8	-0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.9	-0.6	-0.5	-0.9
Pulse rate	0.6	1.0	1.6	-1.2	-0.0	1.3
Happiness	1.0	1.2	2.4	1.6	0.4	1.0
Noisy workplace	2.0	2.5	5.3	0.5	1.3	2.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	5.9	-1.0	-0.9	-2.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	-1.1	-1.0	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	-0.7	0.8	0.7
Asthma	0.3	0.5	0.9	0.9	-0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.9	1.1	-0.9	1.4
Medication: Cholesterol lowering	1.2	1.8	2.2	-1.2	1.3	1.5
Depression (self-reported)	0.6	0.7	1.1	-0.8	-1.0	0.7
Medication: Lansoprazole	0.1	0.2	0.5	-0.1	-0.7	0.1
Prospective memory result	0.5	0.6	1.1	1.0	0.8	-0.3
Lung cancer (father)	0.1	0.1	0.1	-0.2	-0.3	0.4
Illnesses of mother	0.7	0.8	2.2	0.5	1.5	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.7	-0.5	-0.8	-0.8
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	-0.4	-0.1	-0.9
Impedance of arm (left)	0.8	3.5	8.7	0.4	-3.0	-1.3
Arm fat mass (right)	0.2	0.8	1.6	-1.3	-0.9	-0.1
Trunk predicted mass	0.2	1.0	1.9	-0.6	1.4	-0.8
Standing height	0.1	0.6	1.7	-0.4	-0.2	-1.3
Length of working week for main job	1.6	1.7	2.8	-1.7	1.0	-1.2
Exposure to tobacco smoke at home	0.3	0.4	0.9	0.9	-0.2	0.4
Breastfed as a baby	0.5	0.6	1.4	-0.5	1.2	-0.3
Tense / ‘highly strung’	1.5	2.5	7.0	0.4	-2.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.8	5.8	15.0	0.8	-3.9	-1.3
Hair/balding pattern: Pattern 4	1.0	2.5	3.6	1.9	-1.5	-1.3
Birth weight of first child	0.3	0.6	1.8	-1.3	-0.0	0.1
Peak expiratory flow (PEF)	0.0	0.1	0.3	0.1	-0.5	0.1
Pulse wave reflection index	0.3	0.4	0.7	0.8	0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	-0.6	-1.5	0.0
Loud music exposure frequency	0.1	0.1	0.3	0.6	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.0	0.3	1.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.5	-0.2	-0.3
Blood clot in the leg (DVT)	0.3	0.4	1.2	1.1	0.0	0.2
Medication: Paracetamol	0.4	0.7	1.3	0.4	-0.7	1.1
Headache pain in last month	0.0	0.0	0.1	0.3	-0.2	0.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.1	0.9	-1.8	-1.3
Glaucoma (self-reported)	1.5	1.7	3.1	1.0	-1.0	-1.8
Gout (self-reported)	0.4	0.6	0.9	1.0	-0.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.4	0.3	0.4
Medication: Amlodipine	0.1	0.1	0.3	0.5	-0.1	0.2
Medication: Ventolin 100micrograms inhaler	0.7	1.0	1.9	0.8	-0.5	1.4
Birth weight	0.9	2.0	2.8	1.1	1.7	-1.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	0.2	-0.5
High blood pressure (siblings)	0.2	0.3	0.9	0.3	0.9	0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	-0.3	0.1	-0.9
Body fat percentage	0.5	1.9	3.0	-1.4	-1.7	0.9
Leg fat percentage (right)	0.6	2.1	4.9	-1.1	-0.5	2.2
Arm fat-free mass (right)	0.2	0.9	1.8	-0.9	1.3	0.3
Exposure to tobacco smoke outside home	0.6	0.8	1.7	0.0	0.8	-1.3
Comparative body size at age 10	0.3	0.9	2.2	-1.5	0.6	-0.5
Number of full brothers	3.1	3.8	6.8	1.9	2.6	1.0
Worry too long after embarrassment	0.3	0.6	0.9	-0.9	-0.9	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	6.3	-1.4	-2.5	-1.0
Wheeze or whistling in the chest in last year	0.6	1.0	2.7	-0.4	0.3	1.6
Number of children fathered	0.3	0.4	0.7	0.6	0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	4.3	0.5	-2.1	-0.3
Age at first live birth	0.2	0.4	0.8	0.6	-0.9	-0.4
Pulse wave peak to peak time	0.3	0.4	1.0	0.5	0.0	1.0
Health satisfaction	0.5	0.6	1.4	0.7	0.2	1.2
Shortness of breath walking on level ground	0.8	1.0	2.0	-0.6	-0.8	1.4
Qualifications: College or University degree	0.3	0.9	1.9	-1.4	-0.6	-0.7
Eye problems/disorders: None of the above	0.7	0.8	2.1	1.4	0.3	0.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	-0.5	1.3	-0.5
Emphysema/chronic bronchitis	1.6	1.8	5.2	0.6	0.1	2.3
Medication for pain relief, constipation, heartburn	0.6	1.0	2.1	-0.6	1.4	-0.9
Neck or shoulder pain in last month	0.3	0.5	0.6	-0.8	-0.6	0.7
Medication: Blood pressure	0.7	1.2	2.3	-0.3	1.5	1.0
Angina (self-reported)	2.7	3.6	6.7	-1.9	-2.6	0.6
Migraine (self-reported)	2.6	3.3	6.1	-1.5	1.3	2.5
Medication: Ibuprofen	1.4	1.7	4.6	0.2	-0.6	2.2
Medication: Allopurinol	0.7	1.0	1.7	1.0	-0.3	-1.3
Medication: Omeprazole	0.8	1.0	2.3	-0.7	-1.5	-0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.1	-0.0	-0.4	0.2
Mean time to correctly identify matches	0.1	0.3	0.5	-0.2	0.7	0.5
Heart disease (mother)	3.1	3.8	5.3	-1.0	-2.3	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.8	4.6	12.5	0.1	3.5	1.1
Whole body fat mass	0.3	1.4	2.2	-1.5	-1.3	0.5
Leg fat mass (right)	0.3	1.3	2.1	-1.2	-0.4	1.4
Arm predicted mass (right)	0.2	1.2	2.5	-1.1	1.6	0.2
Pulse rate, automated reading	0.4	1.3	3.3	-0.5	-0.6	1.8
Alcohol intake frequency.	0.1	0.2	0.4	-0.6	-0.4	0.0
Comparative height size at age 10	0.2	1.2	3.0	-1.7	-0.4	-0.7
Number of full sisters	2.1	2.6	3.2	-1.7	-1.3	-1.8
Suffer from ‘nerves’	1.5	2.3	6.4	-0.7	-2.5	0.2
Overall health rating	1.0	2.1	6.1	0.2	-0.2	2.5
Chest pain or discomfort	1.1	1.6	2.3	-1.5	-1.5	0.7
Had major operations	0.1	0.2	0.3	0.4	-0.6	-0.2
Age at last live birth	0.3	0.5	0.7	-0.5	-0.9	-0.6
Family relationship satisfaction	1.2	1.5	2.8	1.7	0.5	1.1
Leg pain on walking	0.6	0.8	1.7	-0.3	-0.8	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.0	-0.5	-1.0	-0.0
Commuting to job workplace: Car/motor vehicle	1.4	1.7	3.0	-0.2	-1.4	-1.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.6	0.7	0.4	0.8
Medication: Aspirin	1.2	1.5	4.4	-0.5	-2.1	0.0
Supplements: Vitamin C	1.1	1.3	3.6	0.3	0.6	1.9
Knee pain experienced in last month	0.7	1.1	1.6	-1.3	-1.0	0.8
Hypertension (Self-reported)	0.2	0.6	1.1	-0.7	1.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.1	-0.2	1.4	0.9
Illnesses of father: Heart disease	1.1	1.5	3.8	0.5	0.6	-2.0
Illnesses of siblings: Diabetes	0.5	0.7	1.0	1.0	0.1	1.0
Smoking status: Previous	3.5	5.2	13.2	0.3	-1.5	-3.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	-0.2	-0.3	-1.1
Whole body fat-free mass	0.1	0.8	0.8	-0.8	0.9	-0.9
Leg fat-free mass (right)	0.3	1.7	4.2	-0.9	-0.0	-2.1
Arm fat percentage (left)	0.4	1.8	4.2	-1.1	-2.0	-0.1
Average weekly red wine intake	1.1	1.7	3.2	-1.2	1.8	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.6	0.3	-0.6
Mood swings	0.2	0.4	1.2	0.2	-1.1	0.2
Loneliness, isolation	0.5	0.7	1.6	-0.3	-0.6	-1.3
Long-standing illness, disability or infirmity	0.5	0.7	1.1	-1.0	-0.4	1.1
Ever had bowel cancer screening	1.7	1.9	5.3	0.5	-2.3	-0.5
Diabetes diagnosed by doctor	1.3	2.1	4.7	-1.2	-2.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.1	-0.2	-0.2
Friendships satisfaction	0.7	0.9	2.4	0.2	1.5	0.5
Qualifications: nursing, teaching	0.3	0.5	0.8	-0.2	-0.9	-0.8
Commuting to job workplace: Walk	1.3	1.4	3.5	-0.6	0.5	1.9
Eye problems/disorders: Cataract	3.2	3.7	4.5	-2.0	-1.6	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.3	-0.9	-0.4
Medication for cholesterol	0.3	0.4	0.8	0.6	-0.2	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.1	-1.1	-0.5	1.5
Back pain experienced in last month	1.5	2.2	4.8	-2.2	-0.7	-1.2
Mineral and other dietary supplements	0.6	0.8	1.8	0.7	1.4	-0.1
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.4	-0.2
Asthma (self-reported)	0.2	0.3	0.5	0.6	-0.7	0.4
Osteoporosis (self-reported)	0.4	0.5	1.3	0.4	1.1	0.0
Osteoarthritis (self-reported)	0.5	0.7	1.2	-1.1	-0.5	0.7
Medication: Aspirin	0.8	1.0	2.8	-0.5	-1.7	-0.0
Medication: Gliclazide	0.5	0.5	1.0	-1.0	-0.0	0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	1.0	-0.4	-1.0	0.9
Smoking status: Current	0.3	0.5	1.4	-0.0	-0.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	0.8	0.1	-0.6
Whole body water mass	0.1	0.7	0.8	-0.7	0.9	-0.9
Leg predicted mass (right)	0.3	1.6	4.1	-0.8	-0.1	-2.0
Arm fat mass (left)	0.3	1.1	1.6	-1.3	-1.2	-0.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	-0.0	-1.4	-0.9
Average weekly champagne plus white wine intake	0.5	0.6	0.9	1.0	-0.5	-0.8
Miserableness	0.8	1.3	2.0	1.4	-1.3	-0.6
Guilty feelings	2.0	2.9	6.3	-2.5	-1.4	-0.7
Wears glasses or contact lenses	0.6	0.7	1.6	-1.3	-0.6	0.2
Ever taken oral contraceptive pill	0.4	0.4	0.6	0.3	-0.8	0.8
Hearing aid user	1.1	1.3	1.9	-0.9	1.1	1.4
Mother’s age at death	0.3	0.3	0.9	0.1	0.3	1.0
Financial situation satisfaction	0.2	0.2	0.6	0.8	-0.1	-0.3
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.2	0.1	0.8	-1.5
Commuting to job workplace: Public transport	0.6	0.7	1.5	-0.5	0.7	1.2
Eye problems/disorders: Glaucoma	1.0	1.2	3.0	1.7	0.6	-0.3
Medication: Blood pressure	0.9	1.6	2.9	-1.7	-0.2	1.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.2	-1.5	0.7	-0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.4	-0.9	-2.1	0.2
High cholesterol (Self-reported)	3.2	5.7	13.1	-1.4	3.6	1.5
Medication: Bendroflumethiazide	0.5	0.7	0.9	-0.7	0.9	0.9
Medication: Paracetamol	0.6	0.9	2.0	-0.7	-1.4	0.4
Medication: Lisinopril	0.8	1.0	2.5	0.4	-1.6	-0.7
Medication: Atorvastatin	0.3	0.3	0.6	-0.4	-0.8	0.5
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.9	-0.5	-0.7
Alcohol drinker status: Never	0.7	0.8	2.2	-0.4	1.5	0.3
Ever smoked	0.6	1.1	3.0	-0.4	-0.4	-1.7
Basal metabolic rate	0.1	0.6	0.9	-0.9	0.5	-0.9
Leg fat percentage (left)	0.3	1.3	1.8	-1.3	-0.4	1.3
Arm fat-free mass (left)	0.2	1.1	2.6	-0.8	1.6	0.2
Number of operations (self-reported)	0.2	0.3	0.6	0.8	0.3	0.3
Average weekly beer plus cider intake	0.2	0.2	0.5	-0.7	-0.5	-0.2
Irritability	0.3	0.5	0.6	0.7	-0.7	-0.8
Risk taking	0.9	1.3	2.3	-1.5	-0.7	1.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.5	-0.5	-1.2	-1.2
Fractured/broken bones in last 5 years	0.6	0.8	1.4	0.2	-1.0	-1.2
Age started oral contraceptive pill	2.0	2.5	5.6	-0.7	1.1	2.4
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	-0.1	0.7
Ever depressed for a whole week	1.6	2.0	3.7	-0.8	-1.3	1.9
Unable to work because of sickness or disability	0.5	0.6	1.4	-0.6	-1.2	-0.2
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.1	0.7	0.6
Myopia	1.3	1.9	5.2	0.0	-0.6	-2.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.8	1.1	-1.0	-1.3
Cholesterol lowering medication	0.0	0.0	0.0	0.0	0.2	0.0
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	5.9	-0.8	-2.4	-0.7
Pain experienced in last month	0.3	0.5	0.7	0.8	0.1	-0.8
Supplements: Calcium	0.3	0.3	0.7	0.9	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.7	0.5	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	-0.1	0.2	1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	1.0	0.2	0.1
Heart disease (siblings)	0.3	0.3	0.6	0.8	0.6	-0.3
Alcohol drinker status: Previous	1.6	1.8	4.5	2.1	-0.4	-0.9
Pack years of smoking	0.8	1.2	2.3	-1.5	-0.3	1.1
Impedance of whole body	0.2	0.8	2.2	0.5	-1.5	0.3
Leg fat mass (left)	0.2	0.9	1.8	-1.3	-0.4	0.9
Arm predicted mass (left)	0.2	1.2	2.6	-0.9	1.6	0.3