Hub : Genes

TRIM58

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3810	0.0490	0.0e+00	0.104	0.314	0.335	NA	0.312	1.2e-12	5.3e-39	4.8e-42	NA	1.3e-38
2	YFS	Blood	0.2117	0.0349	0.0e+00	0.086	0.097	0.103	0.116	0.120	1.2e-26	6.0e-30	6.8e-32	7.3e-36	5.4e-37
3	TCGA	Bladder Urothelial Carcinoma	0.0720	0.0370	1.0e-03	0.016	0.039	0.021	NA	0.031	1.6e-02	3.0e-04	6.1e-03	NA	1.1e-03
4	TCGA	Glioblastoma Multiforme	0.1900	0.0690	1.0e-04	0.092	0.122	0.127	NA	0.130	9.5e-04	1.5e-04	1.1e-04	NA	9.4e-05
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1310	0.0520	7.1e-04	0.025	0.053	0.040	NA	0.034	1.4e-02	5.4e-04	2.5e-03	NA	5.0e-03
6	TCGA	Brain Lower Grade Glioma	0.1004	0.0302	8.6e-14	0.122	0.132	0.114	NA	0.124	9.6e-14	8.6e-15	7.8e-13	NA	5.8e-14
7	TCGA	Liver Hepatocellular Carcinoma	0.1730	0.0770	2.5e-03	0.002	0.062	0.004	NA	0.015	2.6e-01	7.1e-04	2.0e-01	NA	6.1e-02
8	TCGA	Lung Adenocarcinoma	0.0309	0.0158	2.3e-03	0.020	0.020	0.015	NA	0.022	1.9e-03	1.9e-03	6.0e-03	NA	1.3e-03
9	TCGA	Pancreatic Adenocarcinoma	0.1140	0.0580	3.9e-03	0.052	0.036	0.000	NA	0.025	3.3e-03	1.2e-02	3.3e-01	NA	3.1e-02
10	TCGA	Stomach Adenocarcinoma	0.0490	0.0230	1.4e-03	0.004	0.032	0.010	NA	0.011	1.5e-01	2.0e-03	5.8e-02	NA	5.0e-02
11	TCGA	Thyroid Carcinoma	0.0420	0.0220	3.3e-03	0.023	0.014	0.012	NA	0.010	2.3e-03	1.5e-02	2.3e-02	NA	3.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.6	1.8	-0.5	-0.7	-0.9	-0.8	-0.5	-0.6	-0.1	-0.7	-0.9	-1.1	-1.3
Bipolar Disorder or Schizophrenia	0.3	0.8	3.0	1.7	0.4	0.4	0.7	1.2	1.1	-0.3	0.7	0.7	1.0	0.6
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.7	-0.7	-0.5	-0.3	-0.6	-0.6	-0.1	-0.3	-0.2	-0.6	-0.5
Depression (Nagel 2018)	1.2	1.8	4.1	-0.6	-1.7	-1.2	-1.7	-1.0	-1.2	-1.5	-1.3	-2.0	-1.0	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	1.7	-0.2	-0.3	-0.5	-0.1	-0.6	-0.1	-1.3	-0.2	0.2	-0.0	0.0
Neuroticism (Nagel 2018)	1.0	2.4	4.1	-1.9	-1.6	-1.7	-1.4	-1.0	-2.0	0.2	-1.4	-1.3	-1.7	-1.7
Schizophrenia (2018)	1.4	3.0	6.8	2.6	1.1	1.2	1.5	1.9	2.0	-0.4	1.5	1.6	2.1	1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	4.3	2.1	-0.4	0.5	0.3	1.6	0.6	-0.8	0.3	0.6	0.9	0.6
Worry (Nagel 2018)	2.8	5.9	10.0	-2.7	-2.6	-2.5	-2.5	-1.0	-3.2	0.2	-2.6	-2.0	-2.8	-2.8
Alzheimer’s Disease (in mother)	0.6	0.7	3.3	-0.4	0.5	-0.1	-0.4	-1.8	-0.1	1.2	-0.4	-1.6	-0.2	0.5
Alzheimer’s Disease (in father)	0.4	0.4	1.1	-0.0	-1.0	-0.2	-0.6	0.7	-0.5	-0.6	-0.5	-1.1	-0.6	0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	4.9	0.5	-0.2	-0.4	-0.5	-0.8	0.1	0.4	-0.6	-2.2	0.0	1.1
Crohns Disease (2017)	0.4	0.9	2.0	-0.3	1.0	1.0	1.4	1.1	0.8	0.2	1.4	1.4	0.5	0.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.8	-0.4	0.8	1.1	1.5	1.4	1.2	-0.2	1.2	1.9	0.7	0.4
Ulcerative Colitis (UC)	0.4	0.7	1.9	-0.2	0.7	1.1	1.1	1.1	0.7	0.3	1.0	1.4	0.3	0.1
Major Depression (MDD)	0.3	0.4	1.6	1.2	-0.1	0.0	0.3	-0.0	0.6	0.3	0.4	-0.2	0.7	1.3
Reaction Time	0.2	0.4	2.3	-0.2	-0.2	1.1	-0.1	-1.5	-0.5	0.6	-0.5	0.1	-0.4	-0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.6	0.6	-1.2	-1.3	-0.7	-1.6	-0.7	-1.1	-0.6	-0.1	-0.4	-0.2
Breast Cancer	0.4	1.0	3.5	-0.5	1.1	1.9	1.3	-1.0	0.3	1.4	1.0	0.6	-0.0	0.6
Ovarian Cancer	0.5	0.6	2.4	-0.1	-0.5	-0.6	-1.0	-0.7	-0.1	-1.6	-0.5	-1.5	-0.2	-0.0
Prostate Cancer	0.4	0.6	1.5	0.2	-0.9	-0.5	-1.2	-0.1	-0.8	-0.5	-0.9	-1.2	-0.8	-0.8
Age at First Birth	1.9	2.7	6.5	1.8	1.2	0.6	1.9	0.6	2.3	-0.2	1.5	2.5	2.2	1.4
Bipolar Disorder (2011)	0.4	0.4	1.7	0.0	0.0	-0.2	-0.8	-0.6	-0.5	-0.6	-0.6	-1.3	-0.9	-0.6
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	0.0	0.9	-0.2	0.4	1.0	0.4	0.3	1.2	-0.4	0.7	1.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.7	3.9	-2.0	-0.1	-0.4	-0.4	-0.9	-0.8	0.0	-0.2	0.3	-1.0	-0.7
Mean Putamen Volume	0.6	0.7	1.4	1.1	1.0	0.4	1.0	1.2	0.7	1.1	0.9	0.3	0.6	0.3
Fasting Glucose	0.9	1.1	3.0	-1.1	1.4	1.7	1.1	0.1	0.6	1.7	1.1	0.5	0.6	0.3
HbA1C	1.7	1.9	6.0	1.7	1.8	1.5	1.3	0.3	0.4	2.4	1.4	0.9	0.8	0.8
HDL Cholesterol	0.4	0.7	2.8	-0.2	-1.2	0.3	-0.5	-1.4	-0.1	-0.6	-1.7	0.6	-0.5	-0.5
LDL Cholesterol	0.0	0.0	0.2	-0.3	0.0	-0.4	-0.4	0.2	-0.2	0.0	0.1	-0.2	-0.0	-0.1
Lupus	0.3	0.4	2.6	-0.8	0.2	-0.4	-0.3	1.6	-0.0	-0.8	0.5	0.2	0.2	-0.4
Neuroticism (2016)	1.8	2.6	4.9	-1.8	-1.7	-2.2	-1.5	-0.8	-1.9	-0.0	-2.2	-1.1	-1.8	-1.4
Primary Biliary Cirrhosis	0.3	0.5	3.0	-1.7	0.7	0.5	-0.1	-0.6	0.1	0.3	0.2	-1.0	0.0	0.2
Rheumatoid Arthritis	0.2	0.3	1.0	0.2	0.8	-0.2	0.7	-0.2	0.6	1.0	0.3	0.7	0.6	0.1
Schizophrenia (2014)	0.7	1.4	4.4	2.1	0.6	1.2	0.8	1.6	1.3	-0.3	1.0	0.5	1.3	1.3
Triglycerides	0.3	0.4	2.0	1.1	0.2	-0.1	0.3	1.4	0.5	0.1	0.7	-0.2	0.7	0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.4	-1.5	-1.2	-1.6	-1.3	-1.1	-1.1	-0.3	-1.2	-0.3	-0.5	-0.8
Ulcerative Colitis	0.2	0.3	1.3	0.6	-0.1	0.4	0.3	0.4	0.1	-0.5	0.0	1.1	-0.6	-0.5
Blood Eosinophil Count	0.1	0.5	1.5	1.0	1.1	0.5	-0.0	0.3	-0.3	0.7	1.2	-0.7	0.3	-0.2
Blood Platelet Count	10.7	124.4	252.8	-8.5	-13.5	-12.5	-11.7	-9.1	-11.5	-0.4	-15.9	-3.2	-11.8	-14.3
Blood Red Count	1.4	14.0	30.5	3.0	5.1	4.9	3.5	0.4	3.3	-0.1	5.5	-0.4	4.2	4.8
Blood White Count	0.4	2.7	16.6	0.2	0.8	0.4	0.1	0.7	1.6	-4.1	1.6	-0.9	1.9	1.4
Heel T-Score	0.1	0.7	2.4	0.0	-0.4	-1.6	-0.7	-1.1	-0.5	-0.1	-1.0	-0.0	-0.9	-1.3
BMI	0.0	0.2	0.6	0.5	0.8	0.4	0.4	0.1	0.1	0.1	0.1	0.5	0.2	0.5
Height	0.0	0.5	2.3	1.4	0.5	0.2	0.4	0.9	0.4	1.5	0.2	0.3	-0.1	-0.2
Waist Hip Ratio (WHR)	0.1	0.3	1.8	0.7	-0.5	-1.0	-0.2	1.3	-0.0	-0.2	0.1	-0.3	0.1	-0.4
Systolic Blood Pressure	0.1	0.7	3.2	-0.6	1.0	0.9	0.2	-0.9	-0.3	1.8	0.6	-0.6	-0.1	0.4
Smoking Status	0.7	1.8	5.6	-1.7	-1.1	-2.4	-1.4	1.4	-1.0	-0.4	-0.8	-0.4	-0.7	-1.8
Allergy or Eczema	0.1	0.3	1.1	0.4	-1.1	0.5	-0.1	-0.3	-0.5	-0.6	-0.7	0.1	-0.3	-0.6
Cardiovascular Disease	0.2	0.8	3.4	-0.8	0.1	0.4	-0.2	-0.7	-1.2	1.9	-0.1	-1.1	-1.0	-0.2
Hypothyroidism (self reported)	1.4	3.2	5.7	-0.1	2.1	2.1	2.4	1.6	1.5	1.8	2.4	1.4	1.4	1.6
Respiratory disease	0.6	1.3	4.7	-0.2	0.4	-0.1	-0.5	-1.9	-1.1	1.9	-0.3	-2.2	-0.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.6	-0.5	0.6	1.6	0.5	0.6	-0.3	1.5	0.4	-0.0	-0.3	0.0
Lung FEV1/FVC ratio	0.2	0.9	2.7	1.6	0.2	1.5	0.8	1.0	1.0	0.1	0.3	0.5	0.5	1.3
Lung FVC	0.0	0.1	0.4	-0.0	0.6	-0.1	0.2	-0.3	0.1	-0.1	0.1	-0.2	-0.0	-0.1
Neuroticism	1.3	3.2	4.8	-1.6	-1.9	-2.0	-2.0	-1.3	-2.0	-0.9	-2.2	-1.8	-1.8	-1.7
Chronotype (morning person)	0.2	0.5	3.2	0.2	0.7	1.8	0.6	0.1	0.1	0.9	0.6	0.1	-0.0	0.6
Hair Pigment	0.0	1.3	6.0	0.5	1.0	0.1	0.8	2.4	0.9	0.8	1.0	0.6	1.4	1.3
Tanning	0.0	0.4	1.3	0.2	1.1	-0.6	0.5	-1.0	0.3	0.8	0.9	0.3	0.7	0.1
Hand grip strength (left)	0.4	1.0	3.3	0.4	1.1	0.4	1.1	0.8	1.6	-0.2	0.9	0.9	1.8	0.8
Number of treatments/medications taken	0.2	0.4	1.7	-1.1	-0.0	-1.3	-0.4	0.4	-0.4	-0.4	0.1	-1.0	-0.0	0.1
Average weekly spirits intake	0.5	0.6	1.6	1.1	1.2	0.6	0.9	0.6	0.1	0.8	1.1	0.2	0.4	0.5
Sensitivity / hurt feelings	0.3	0.5	2.5	0.0	-0.2	-1.1	0.0	-0.4	-1.0	1.6	-0.0	-0.2	-0.6	-0.6
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.2	-1.1	-1.0	-0.8	-0.9	-0.5	-0.6	-1.4	-0.5	-1.8	-0.3	-0.1
Hearing difficulty/problems: Yes	1.1	1.7	5.4	-0.8	-0.2	-0.3	-0.9	-2.1	-1.3	0.9	-1.2	-2.3	-1.7	-0.9
Relative age of first facial hair	0.1	0.2	0.9	-0.4	0.1	0.5	0.2	0.9	0.6	-0.5	0.2	-0.4	0.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	0.2	0.7	1.0	1.0	-0.1	0.5	0.6	0.5	0.8	0.5	1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.2	0.3	0.8	-0.2	0.3	0.2	0.4	0.1	0.5	-0.8	0.3	1.1
Ever had hysterectomy (womb removed)	2.6	2.9	6.1	-1.1	-2.5	-1.3	-2.0	-1.1	-1.8	-0.1	-2.4	-0.9	-2.0	-2.0
Systolic blood pressure, automated reading	0.2	0.5	3.3	-0.3	0.7	0.9	0.0	0.1	-0.4	1.8	0.3	-0.6	-0.6	0.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.2	1.5	0.6	1.1	0.5	0.3	0.5	0.8	0.7	-0.0	0.5	1.3
Angina	0.6	0.7	2.2	-0.6	0.3	0.4	0.4	1.2	0.8	-1.1	0.8	-0.3	1.0	1.5
Medication for hormone replacement therapy	0.1	0.1	0.4	0.0	-0.1	0.1	-0.5	-0.6	-0.6	-0.3	-0.6	0.1	-0.1	-0.2
Vitamin and mineral supplements	0.4	0.5	2.1	-0.2	0.9	1.0	0.0	-0.8	-0.0	0.6	-0.1	-1.4	-0.4	0.3
Supplements: Zinc	0.4	0.4	1.4	0.4	0.2	-0.3	0.5	1.2	0.4	-0.1	0.9	0.8	0.7	0.4
Medication: Co-codamol	0.7	0.8	2.2	0.6	0.5	-0.7	0.1	1.4	0.4	-1.5	1.2	-0.1	0.9	1.2
Medication: Metformin	0.9	1.3	3.5	-0.2	-0.9	-0.6	-0.8	-0.0	-1.3	1.9	-1.3	-0.8	-1.6	-1.3
Diabetes (father)	1.2	1.5	4.6	-1.1	-0.3	-1.7	-1.2	-1.3	-1.1	-0.5	-0.7	-2.1	-1.1	-1.1
Diabetes (mother)	0.5	0.6	3.0	0.6	0.3	0.3	0.4	1.7	0.1	1.1	0.3	1.0	0.3	-0.5
Severe depression (siblings)	0.5	0.6	2.1	0.7	-0.2	-0.3	-0.5	-1.2	-0.9	0.1	-0.3	-1.5	-0.9	-0.3
Pack years adult smoking proportion	0.8	1.2	2.7	-1.6	-1.0	-1.7	-1.2	0.2	-0.5	-1.3	-1.3	-0.8	-0.6	-0.8
Impedance of leg (right)	0.0	0.2	0.7	0.7	-0.8	0.1	-0.2	-0.1	-0.1	-0.9	-0.1	0.3	0.0	-0.0
Leg fat-free mass (left)	0.0	0.2	0.9	-0.6	0.3	0.1	-0.1	-0.0	-0.3	0.9	-0.6	-0.0	-0.3	-0.4
Trunk fat percentage	0.3	1.3	2.8	-0.8	-0.9	-1.2	-1.3	0.2	-1.7	-0.3	-1.2	-1.2	-1.4	-1.4
Hand grip strength (right)	0.9	2.3	3.6	0.5	1.7	1.7	1.9	1.4	1.8	0.8	1.6	1.6	1.8	1.2
Townsend deprivation index at recruitment	0.7	1.0	2.8	-0.1	1.7	1.1	0.9	0.7	1.2	0.2	1.4	0.4	1.2	1.1
Current tobacco smoking	1.0	1.6	5.1	-1.6	-1.2	-2.2	-1.3	1.5	-0.6	-1.4	-0.8	-0.3	0.0	-1.5
Average weekly fortified wine intake	0.1	0.1	0.4	0.4	-0.6	0.1	0.2	0.3	-0.1	-0.7	0.1	-0.0	-0.5	0.1
Maternal smoking around birth	3.1	4.5	7.2	-2.7	-2.2	-2.4	-2.2	-1.5	-2.2	-0.4	-2.5	-1.1	-2.6	-2.4
Fed-up feelings	0.2	0.3	1.2	0.1	-0.1	-0.4	0.3	1.1	0.3	-1.1	0.5	0.1	0.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.6	-0.1	-2.0	-0.6	-1.8	-1.4	-1.0	-2.4	-1.8	-2.0	-1.0	-0.6
Relative age voice broke	0.6	0.9	6.8	-0.6	-1.1	-0.9	-0.7	0.3	0.2	-2.6	-0.4	-0.2	0.2	0.2
Taking other prescription medications	0.2	0.3	1.7	-1.3	-0.2	-0.7	-0.2	-0.0	-0.1	0.2	-0.3	-1.0	-0.0	0.1
Age when periods started (menarche)	0.4	0.9	4.0	-0.0	0.1	1.0	0.8	2.0	0.9	0.0	1.3	1.0	0.5	0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.8	-0.5	-1.7	-1.5	-1.5	0.3	-0.9	-0.6	-1.4	-0.1	-0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.5	2.1	0.6	0.4	1.1	-0.1	1.0	-0.5	1.0	1.7	1.4	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.8	-0.4	-0.4	0.0	-0.3	-1.3	-0.6	0.4	-0.5	-0.9	-0.8	-0.0
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.3	-0.1	0.1	0.1	-0.3	0.2	0.1	-0.7	0.3	0.1	-0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.3	0.2	-0.1	0.2	-0.4	0.7	0.5	-0.5	-0.1	0.5	0.7
High blood pressure	0.6	1.7	3.4	-1.8	-0.7	-0.7	-0.8	-1.0	-1.5	1.5	-1.4	-1.2	-1.9	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	3.1	0.4	-1.8	0.4	-0.3	-0.4	-0.8	-0.9	-0.9	0.3	-0.3	-0.7
Multivitamins +/- minerals	0.4	0.5	1.3	0.4	-0.9	-1.1	-0.5	0.4	-0.3	-1.0	-0.6	0.4	-0.1	-1.1
Stomach or abdominal pain in last month	0.4	0.5	2.4	-0.7	-0.1	-0.2	0.6	0.8	0.5	-0.9	0.2	1.6	0.8	0.0
Supplements: Glucosamine	1.7	2.2	5.7	-0.5	-1.9	-1.4	-1.5	-0.4	-1.3	-1.4	-1.6	-0.1	-1.9	-2.4
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.2	0.5	1.7	1.2	1.8	0.7	1.2	1.0	1.6	1.4	1.2	1.1
Medication: Atenolol	0.2	0.2	1.3	-0.4	0.0	-0.3	-0.1	-0.2	-0.2	1.1	-0.4	-0.8	-0.2	-0.0
Medication: Levothyroxine sodium	1.6	2.7	5.3	-0.6	1.5	1.8	2.2	0.6	1.7	0.8	1.8	1.8	1.6	2.3
Sitting height	0.1	0.4	1.2	0.3	1.0	0.6	0.7	-0.8	0.4	1.1	0.6	0.4	0.4	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	2.0	0.2	1.4	0.4	0.9	0.5	0.5	0.8	0.7	0.0	0.1	0.6
High blood pressure (mother)	1.3	1.8	3.9	-2.0	-0.7	0.3	-1.1	-1.4	-1.8	1.2	-1.0	-1.8	-1.6	-1.0
Body mass index (BMI)	0.1	0.5	0.9	-0.9	-0.1	-0.7	-0.6	0.8	-1.0	0.5	-0.6	-0.8	-0.8	-0.7
Impedance of leg (left)	0.1	0.4	2.7	0.6	-0.7	-0.6	-0.2	0.1	0.2	-1.6	0.2	0.4	0.5	0.2
Leg predicted mass (left)	0.0	0.2	0.8	-0.5	0.4	0.2	-0.0	-0.1	-0.2	0.9	-0.6	-0.0	-0.2	-0.3
Trunk fat mass	0.2	1.0	2.0	-0.7	-0.6	-1.1	-1.2	0.4	-1.4	0.0	-1.1	-1.1	-1.2	-1.3
Waist circumference	0.3	1.0	1.4	-1.0	-0.4	-1.1	-0.9	0.9	-1.2	0.8	-0.9	-1.1	-1.1	-1.1
Number of incorrect matches in round	1.0	1.6	5.5	-1.4	-1.0	-2.3	-1.4	-0.1	-1.2	0.1	-1.1	-1.3	-0.8	-1.7
Past tobacco smoking	0.4	0.7	2.3	1.5	-1.0	0.5	-0.3	-1.5	-0.0	-1.1	-0.8	0.2	-0.5	0.3
Alcohol usually taken with meals	2.5	4.1	7.7	2.6	1.2	2.1	2.3	0.7	2.1	-0.4	1.7	2.8	2.0	2.6
Nervous feelings	3.1	5.7	10.6	-2.2	-3.2	-2.0	-2.6	-1.0	-3.3	-0.2	-2.9	-1.7	-2.8	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.1	-2.3	-1.7	-1.6	-1.5	-1.0	-1.1	-1.7	-1.4	-2.0	-0.8	-0.8
Hearing difficulty/problems with background noise	1.0	1.6	3.2	-1.8	-0.1	-0.5	-0.7	-1.8	-1.3	1.8	-0.9	-1.1	-1.4	-1.2
Hair/balding pattern: Pattern 2	0.1	0.2	1.1	0.5	0.3	0.3	0.5	-1.0	0.2	0.4	-0.3	0.0	-0.2	0.0
Had menopause	0.4	0.5	1.5	-0.1	0.8	1.2	0.9	-0.1	0.1	0.9	0.8	0.5	-0.0	0.4
Had other major operations	0.8	1.0	3.9	0.2	0.9	1.9	0.7	-0.6	-0.1	2.0	0.9	-0.3	-0.2	0.7
Forced vital capacity (FVC)	0.6	2.1	5.2	1.6	1.5	0.8	1.4	0.4	1.9	-0.7	1.0	1.9	2.3	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	0.6	-0.8	-0.6	-0.5	-0.1	-0.4	-1.1	-0.6	0.6	0.3	-0.7
Ever unenthusiastic/disinterested for a whole week	2.9	3.6	6.1	-1.7	-1.0	-1.9	-2.1	-1.6	-2.0	0.9	-2.1	-2.5	-1.9	-2.3
Qualifications: None of the above	0.6	1.4	3.1	-1.8	-0.2	-1.8	-0.8	1.1	-1.2	1.4	-0.4	-0.8	-0.9	-1.4
Financial difficulties in last 2 years	1.3	1.7	3.4	-1.9	1.1	0.5	1.2	0.9	1.7	-1.4	1.3	1.2	1.4	1.1
Mouth/teeth dental problems	0.6	1.0	2.7	1.1	1.1	1.3	1.0	0.3	0.4	1.1	1.1	1.6	0.5	0.4
Heart attack	2.2	2.9	7.1	-0.9	-0.5	-2.7	-1.7	-1.3	-1.7	1.1	-1.0	-2.6	-1.8	-2.0
Allergy	0.3	0.8	2.3	-0.5	1.5	-0.5	0.7	0.8	1.3	-0.0	1.0	1.1	0.9	0.6
Pain all over the body in last month	0.6	0.6	3.4	-1.0	-0.3	-0.4	-0.2	-1.8	-0.6	-0.7	-0.7	0.3	-0.4	-0.4
Diabetes (self-reported)	0.2	0.3	1.4	-0.9	0.3	0.3	-0.2	0.9	-0.4	1.2	-0.3	-0.3	-0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.7	-0.1	0.6	0.3	-0.2	0.1	-0.1	-0.0	0.2	0.2	0.3
Medication: Ramipril	0.5	0.6	1.7	-0.9	1.3	-0.3	0.5	0.5	0.3	1.3	0.8	-0.9	0.6	0.7
Medication: Simvastatin	0.6	0.9	2.8	-0.0	1.7	0.2	0.6	0.2	0.3	1.6	1.1	-1.0	0.7	1.0
Fluid intelligence score	0.3	0.6	5.0	0.6	-0.0	-0.8	-0.0	-2.2	-0.1	-0.1	0.2	-0.3	0.2	0.2
Illnesses of siblings	0.3	0.4	1.7	0.1	-0.4	0.3	-0.5	-1.3	-0.6	0.7	-0.6	-0.8	-0.7	-0.0
Neuroticism score	2.6	5.4	8.0	-1.8	-2.6	-2.8	-2.4	-1.8	-2.8	-0.5	-2.7	-2.0	-2.5	-2.5
Weight	0.1	0.3	0.6	-0.6	0.2	-0.4	-0.3	0.5	-0.6	0.8	-0.5	-0.3	-0.6	-0.6
Impedance of arm (right)	0.3	1.3	2.5	-0.2	-1.6	-0.6	-1.4	-1.6	-0.9	-1.2	-1.5	-0.6	-1.1	-1.0
Arm fat percentage (right)	0.5	1.9	3.5	-0.9	-1.2	-1.5	-1.7	0.1	-1.9	-0.2	-1.7	-1.5	-1.7	-1.6
Trunk fat-free mass	0.0	0.3	1.4	-0.1	0.8	0.3	0.4	0.5	0.3	1.2	-0.0	0.5	0.3	0.1
Hip circumference	0.3	1.2	2.6	-1.4	-0.7	-1.1	-1.0	-0.1	-1.3	0.2	-1.6	-0.9	-1.4	-1.2
Time employed in main current job	0.5	0.6	1.5	-0.2	-0.9	-0.8	-0.7	-0.7	-0.9	0.7	-1.2	0.3	-0.7	-0.8
Alcohol intake versus 10 years previously	0.5	0.7	2.7	-1.1	-0.8	-1.2	-0.7	0.7	-0.2	-0.1	-0.6	0.8	-0.3	-1.6
Father’s age at death	0.3	0.4	2.4	1.0	-0.8	-0.5	0.0	0.3	0.0	-1.5	-0.3	0.7	0.3	0.0
Worrier / anxious feelings	0.8	1.5	2.9	-1.7	-1.0	-1.4	-1.0	-1.4	-1.4	0.1	-1.5	-1.3	-0.9	-1.2
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	6.4	-2.3	-1.9	-2.3	-1.7	-2.5	-1.6	-2.2	-2.2	-1.7	-1.3	-1.0
Falls in the last year	0.6	0.8	1.6	-1.1	-0.8	-1.3	-0.8	-0.7	-0.8	-1.1	-1.1	-0.2	-0.6	-0.6
Hair/balding pattern: Pattern 3	0.3	0.5	2.5	-0.3	-0.9	-0.4	-0.5	0.4	0.0	-1.6	-0.7	0.7	0.7	0.2
Number of live births	0.2	0.3	1.3	-0.9	-0.5	0.7	-0.0	-0.0	-0.5	-0.2	-0.6	1.1	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	5.8	2.4	1.7	1.5	1.8	0.5	2.2	-0.4	1.3	1.8	2.3	1.9
Pulse rate	1.4	2.4	3.8	-0.4	-1.6	-1.7	-1.8	-1.3	-1.7	-1.5	-1.9	-1.5	-1.4	-1.6
Happiness	1.3	1.6	3.3	-1.7	-1.2	-1.0	-1.3	-1.3	-1.1	-0.3	-1.8	-1.1	-1.4	-1.1
Noisy workplace	0.8	1.0	2.7	-0.4	-1.4	0.2	-0.9	1.7	-0.4	-1.0	-1.5	-0.2	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-0.3	0.0	0.8	0.7	-0.5	0.8	-0.1	-0.1	1.0	0.4	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.1	-0.3	0.3	-0.1	-0.6	-0.5	0.7	-0.4	-0.5	-0.6	-0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	4.3	-0.1	-0.7	-0.6	-0.5	2.1	0.5	-1.6	-0.2	-0.6	0.5	-0.0
Asthma	0.6	1.1	3.6	0.3	1.0	1.2	0.4	-1.9	-0.2	1.9	0.4	-1.3	-0.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.5	1.2	1.3	1.6	1.1	1.0	0.8	-0.4	1.5	0.1	0.7	1.3
Medication: Cholesterol lowering	1.1	1.7	3.5	1.1	1.4	0.8	1.4	1.5	1.4	0.5	1.6	0.0	1.6	1.9
Depression (self-reported)	0.2	0.3	1.2	-0.7	0.4	-0.8	-0.1	-0.4	0.1	0.5	-0.2	-1.1	0.5	0.0
Medication: Lansoprazole	0.3	0.3	1.4	-1.1	0.5	-0.3	0.4	1.2	0.1	-0.6	0.5	-0.1	0.0	0.3
Prospective memory result	0.4	0.5	3.8	-0.5	0.3	-0.9	0.1	2.0	-0.1	0.7	0.6	-0.1	0.0	0.1
Lung cancer (father)	2.3	2.7	6.9	-1.1	-1.1	-2.6	-2.0	-1.0	-1.5	0.8	-2.0	-1.4	-1.2	-2.4
Illnesses of mother	1.3	1.6	5.0	1.2	0.3	-0.1	0.4	-0.0	1.7	-2.2	0.7	1.3	1.9	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.4	1.5	0.5	0.7	1.0	0.1	1.3	-1.2	-0.0	1.5	1.4	0.9
Pulse wave Arterial Stiffness index	0.5	0.5	3.8	1.9	0.2	-0.3	-0.2	-0.5	-0.1	0.9	0.7	-0.7	0.1	-0.2
Impedance of arm (left)	0.5	2.1	3.9	-0.6	-2.0	-1.0	-1.8	-1.4	-1.6	-1.0	-1.8	-1.1	-1.6	-1.6
Arm fat mass (right)	0.3	1.2	2.4	-0.8	-0.7	-1.1	-1.3	0.2	-1.5	0.2	-1.3	-1.2	-1.4	-1.4
Trunk predicted mass	0.0	0.2	1.3	-0.2	0.7	0.2	0.3	0.5	0.3	1.1	-0.1	0.5	0.3	0.1
Standing height	0.1	0.7	1.6	0.9	0.8	0.8	0.9	0.1	0.9	1.0	0.5	1.2	0.8	0.5
Length of working week for main job	1.6	1.8	3.1	-0.5	-1.7	-1.2	-1.8	-1.0	-1.3	-1.4	-1.7	-1.0	-1.4	-1.1
Exposure to tobacco smoke at home	0.2	0.2	0.9	0.9	0.1	-0.1	0.4	0.1	0.7	0.4	0.1	0.6	0.6	0.1
Breastfed as a baby	0.5	0.6	2.7	-1.0	1.2	0.3	0.3	-0.7	0.0	1.6	0.6	-0.1	0.2	0.1
Tense / ‘highly strung’	0.8	1.3	4.5	-2.1	-0.7	-1.9	-0.7	-0.6	-1.1	0.8	-0.5	-0.8	-0.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	1.8	-1.2	-0.7	0.1	-0.9	-1.0	-1.3	0.6	-1.3	-0.9	-0.7	-0.8
Hair/balding pattern: Pattern 4	0.4	0.9	2.7	1.3	0.4	1.6	0.2	0.3	-0.3	1.5	0.3	-1.2	-0.7	0.5
Birth weight of first child	0.4	0.6	2.5	1.6	0.8	0.8	0.6	1.1	0.4	0.8	0.6	-0.5	0.0	0.4
Peak expiratory flow (PEF)	0.9	2.1	5.4	2.3	1.1	1.3	1.4	-0.0	2.0	-0.8	1.0	1.1	1.7	1.7
Pulse wave reflection index	1.0	1.2	3.7	1.7	0.9	0.2	0.7	0.5	1.2	0.7	1.9	-0.2	1.1	1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.6	0.1	-0.1	-0.7	-1.0	-1.1	-0.9	1.1	-1.2	-1.3	-0.7	-0.8
Loud music exposure frequency	0.8	0.9	1.7	-1.1	-0.3	-0.8	-0.4	-0.1	-1.1	1.0	-0.4	-1.3	-1.2	-1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	-0.6	0.7	0.3	0.7	-0.1	1.1	-0.3	-0.0	1.3	1.3	0.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.2	-0.6	-1.1	-0.8	-1.1	-1.5	-1.2	0.4	-1.4	-1.8	-1.5	-1.1
Blood clot in the leg (DVT)	0.5	0.6	2.2	0.3	-0.6	1.1	-0.2	1.5	-0.7	0.5	-0.1	-1.1	-1.0	0.3
Medication: Paracetamol	0.2	0.3	2.2	-0.5	-0.1	-0.3	-0.0	-0.1	0.5	-1.5	0.1	-0.5	0.4	0.7
Headache pain in last month	3.7	6.4	9.4	-3.0	-2.5	-2.6	-2.7	-1.6	-2.9	-0.6	-2.8	-2.0	-2.7	-3.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.3	-1.1	-1.5	-0.9	-1.7	-1.1	-1.5	-0.5	-1.6	-0.5	-1.6	-1.8
Glaucoma (self-reported)	1.0	1.1	3.2	1.2	1.7	0.7	0.9	-0.0	1.0	1.8	0.7	0.7	0.8	1.0
Gout (self-reported)	0.5	0.7	1.9	-1.1	-1.4	-0.3	-0.7	-0.7	-0.7	-0.8	-1.2	0.1	-0.4	-0.6
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	6.4	-0.3	1.8	1.6	2.5	1.4	2.2	1.1	2.0	2.3	2.1	2.1
Medication: Amlodipine	0.4	0.5	2.0	-1.4	-0.3	-0.5	-0.5	-0.7	-0.8	0.3	-0.6	-0.6	-0.8	-0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.6	-0.0	-1.1	-1.1	-1.2	-1.9	-0.9	-0.9	-1.1	-0.2	-0.6	-1.0
Birth weight	1.1	2.4	6.2	0.5	1.9	1.1	1.6	0.8	2.5	-0.2	1.3	1.1	2.3	1.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.4	-2.1	-0.9	-0.9	-0.7	1.1	-0.7	-0.1	-1.1	0.4	-1.0	-2.0
High blood pressure (siblings)	0.2	0.2	0.9	-1.0	0.4	-0.4	0.1	-0.3	0.3	-0.7	0.1	-0.7	0.4	0.3
Forced vital capacity (FVC), Best measure	0.3	0.9	2.6	1.1	0.7	0.5	1.0	-0.3	1.2	-0.9	0.1	1.6	1.4	0.8
Body fat percentage	0.4	1.4	2.5	-1.0	-1.0	-1.4	-1.3	0.7	-1.6	-0.6	-1.2	-1.2	-1.3	-1.4
Leg fat percentage (right)	0.3	1.2	2.1	-1.1	-0.9	-1.4	-1.1	1.1	-1.3	-0.3	-1.0	-0.9	-1.2	-1.2
Arm fat-free mass (right)	0.0	0.2	0.8	-0.4	0.7	0.1	0.4	0.6	0.1	0.9	0.1	0.2	0.2	0.1
Exposure to tobacco smoke outside home	1.3	1.7	3.7	-0.5	-1.0	-0.1	-1.6	-0.3	-1.9	0.6	-1.2	-1.6	-1.9	-1.6
Comparative body size at age 10	0.2	0.4	1.2	0.3	0.3	0.7	0.5	0.8	0.8	-1.1	-0.4	-0.3	0.8	0.7
Number of full brothers	0.1	0.2	0.6	-0.7	0.3	-0.3	-0.1	-0.1	0.4	0.1	0.1	0.5	0.8	0.6
Worry too long after embarrassment	0.6	0.9	2.3	-0.7	-0.7	-1.3	-0.9	-0.9	-0.9	-0.4	-1.5	-0.9	-0.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	3.4	-1.8	-0.3	-0.1	-0.2	-0.5	-0.2	-0.5	-0.7	-0.1	0.1	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	1.9	-1.4	0.4	0.6	0.1	-0.7	-0.1	0.5	-0.4	-0.0	-0.2	-0.2
Number of children fathered	0.2	0.2	1.2	1.1	-0.1	-0.0	0.2	-0.4	0.6	-0.3	-0.2	0.3	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	5.5	1.0	0.7	1.3	1.5	1.1	1.2	0.5	1.4	2.4	1.6	1.2
Age at first live birth	0.7	1.3	4.2	2.0	1.0	0.2	0.8	-1.2	1.5	0.0	0.5	0.8	1.1	1.5
Pulse wave peak to peak time	0.5	0.6	3.3	-1.8	-0.1	0.6	0.4	0.5	0.4	-0.9	-0.6	0.9	0.2	0.5
Health satisfaction	2.0	2.6	5.0	-1.2	-1.8	-2.1	-1.4	-1.4	-1.8	-0.7	-2.2	-0.9	-1.9	-1.7
Shortness of breath walking on level ground	1.1	1.3	3.2	0.2	-1.8	-0.9	-1.5	-0.2	-1.4	-0.5	-1.5	-1.1	-1.4	-0.8
Qualifications: College or University degree	0.5	1.5	4.6	-0.2	-1.6	-0.0	-1.2	-2.1	-0.8	-1.9	-1.4	-0.6	-1.0	0.0
Eye problems/disorders: None of the above	0.8	0.9	1.9	-1.3	-1.1	-0.5	-1.0	0.9	-0.8	0.1	-0.7	-1.4	-1.0	-1.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.3	-2.1	-0.2	-1.8	-1.0	-1.0	-0.5	0.3	-1.0	-1.0	-0.7	-1.2
Emphysema/chronic bronchitis	0.7	0.7	2.3	-0.3	1.1	-0.7	0.5	0.4	1.1	-0.9	0.4	0.6	1.5	1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	2.0	0.2	-0.2	0.5	0.1	-0.5	-0.1	1.1	-0.2	1.4	-0.2	-0.7
Neck or shoulder pain in last month	0.5	0.8	3.3	-1.1	-0.5	-1.7	-0.3	0.1	0.4	-1.8	-0.4	0.3	0.5	0.0
Medication: Blood pressure	0.8	1.5	2.6	0.3	1.5	0.9	1.6	0.7	1.5	0.3	1.4	0.8	1.6	1.5
Angina (self-reported)	0.3	0.4	1.2	-0.7	-0.0	0.2	0.1	0.9	0.4	-0.9	0.5	-0.5	0.6	1.1
Migraine (self-reported)	1.9	2.3	4.7	-1.4	-1.2	-1.5	-1.3	-2.1	-1.3	0.1	-2.2	-1.5	-1.8	-1.3
Medication: Ibuprofen	0.5	0.6	1.5	1.0	1.0	1.2	0.8	0.3	0.4	-0.2	1.0	-0.0	0.5	1.0
Medication: Allopurinol	0.2	0.3	0.9	-0.7	-0.9	0.2	-0.5	-0.3	-0.4	-0.8	-0.4	-0.2	-0.1	0.0
Medication: Omeprazole	0.4	0.4	3.2	-1.8	-0.2	-0.7	-0.3	0.3	-0.4	-0.4	-0.4	-0.1	-0.4	-0.2
Medication: Seretide 50 evohaler	0.3	0.4	1.3	-0.5	-0.6	-0.2	-0.9	-0.1	-0.2	-1.1	-0.7	-0.8	-0.2	-0.6
Mean time to correctly identify matches	0.1	0.3	0.6	-0.8	-0.5	0.7	-0.3	-0.3	-0.7	0.5	-0.4	-0.1	-0.7	-0.5
Heart disease (mother)	0.4	0.4	2.6	0.3	-0.1	1.0	0.6	1.6	0.1	0.2	0.4	0.1	-0.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.1	1.7	1.8	1.4	1.2	0.8	1.2	1.1	1.8	0.5	1.5	1.3
Whole body fat mass	0.2	0.8	1.5	-0.8	-0.6	-1.2	-1.0	0.9	-1.1	-0.2	-0.9	-0.8	-0.9	-1.1
Leg fat mass (right)	0.2	0.7	1.1	-0.9	-0.3	-1.0	-0.8	0.8	-1.0	0.1	-0.9	-0.8	-0.9	-1.0
Arm predicted mass (right)	0.0	0.1	0.8	-0.2	0.4	0.2	0.2	0.7	-0.1	0.9	-0.1	0.2	0.0	-0.1
Pulse rate, automated reading	0.4	1.2	4.7	0.1	-1.0	-1.5	-1.4	1.0	-0.6	-2.2	-0.7	-1.1	-0.2	-0.3
Alcohol intake frequency.	0.2	0.5	2.0	-1.4	-1.0	-0.8	-0.7	0.2	-0.4	-0.2	-0.7	-0.6	-0.8	-0.5
Comparative height size at age 10	0.1	0.5	1.0	0.6	1.0	1.0	0.7	-0.6	0.7	0.9	-0.0	0.7	0.7	0.6
Number of full sisters	0.3	0.3	0.8	-0.3	0.8	0.7	0.6	-0.8	0.6	-0.2	0.1	0.9	0.3	0.2
Suffer from ‘nerves’	4.8	7.6	10.8	-3.1	-2.9	-2.1	-3.2	-1.2	-3.2	-1.1	-3.0	-3.1	-3.3	-2.8
Overall health rating	1.4	2.9	11.1	-3.3	-1.4	-2.5	-1.4	-1.4	-1.0	-1.8	-1.6	-1.1	-0.4	-0.8
Chest pain or discomfort	0.4	0.6	3.2	-1.8	0.3	0.3	0.2	-0.6	0.3	-0.9	-0.2	-0.5	0.2	1.2
Had major operations	0.8	0.9	5.8	-1.0	-0.3	-0.5	-0.8	-2.4	-0.8	0.1	-0.8	-0.3	-0.3	-0.8
Age at last live birth	1.0	1.4	2.8	1.0	1.1	1.1	1.3	-1.0	1.7	-0.2	0.9	1.2	1.5	1.6
Family relationship satisfaction	0.4	0.5	1.5	-0.0	0.6	0.5	0.2	0.3	1.2	-1.2	-0.5	0.8	1.0	0.6
Leg pain on walking	2.3	2.9	5.6	-0.3	-2.0	-1.8	-2.0	-0.9	-1.7	-0.5	-2.4	-2.0	-2.1	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.1	-0.0	-0.3	-0.4	-0.7	-0.2	-0.3	-0.6	-1.0	-0.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.1	-0.2	1.0	-0.5	0.2	-0.2	0.9	0.1	-0.1	0.2	0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	1.0	-0.6	-0.5	-0.8	-0.8	-0.8	-0.3	-0.6	-0.3	-1.1	-1.4
Medication: Aspirin	1.8	2.4	10.2	-0.5	-0.9	-1.4	-1.6	-1.1	-1.9	0.8	-1.1	-3.2	-1.8	-0.8
Supplements: Vitamin C	0.6	0.7	3.3	0.2	-0.1	0.7	0.8	0.5	0.8	-0.1	1.0	1.8	1.0	1.0
Knee pain experienced in last month	1.0	1.5	5.6	-1.8	-1.1	-2.0	-1.0	-0.1	-0.6	-2.4	-0.9	-0.4	-0.3	-0.9
Hypertension (Self-reported)	0.5	1.4	3.8	-1.8	-0.3	-0.0	-0.3	-0.8	-1.3	1.9	-1.0	-1.1	-1.8	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.0	-0.3	-0.8	-1.7	-1.7	-0.4	-1.3	-0.9	-1.3	-1.7	-1.3	-1.2
Illnesses of father: Heart disease	1.1	1.5	3.6	1.6	1.2	1.6	1.3	-0.5	0.8	0.5	1.4	0.5	1.0	1.9
Illnesses of siblings: Diabetes	0.2	0.3	0.8	-0.1	-0.2	-0.5	-0.3	0.9	-0.5	-0.3	0.2	-0.6	-0.6	-0.7
Smoking status: Previous	0.8	1.2	3.2	-1.0	1.7	0.5	1.0	1.4	0.5	1.8	1.4	0.1	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.5	-0.7	1.3	0.4	1.2	0.2	1.1	0.4	0.7	1.2	1.6	0.9
Whole body fat-free mass	0.0	0.2	1.2	-0.2	0.7	0.4	0.4	0.4	0.3	1.1	-0.1	0.4	0.3	0.2
Leg fat-free mass (right)	0.0	0.1	0.6	-0.7	0.5	-0.2	0.1	0.2	0.0	0.6	-0.3	0.1	0.1	-0.1
Arm fat percentage (left)	0.7	2.8	5.1	-1.2	-1.5	-1.7	-2.0	0.1	-2.3	-0.3	-1.9	-1.9	-2.0	-2.0
Average weekly red wine intake	1.2	1.8	3.3	1.2	1.0	1.8	1.7	-0.7	1.5	-0.9	1.6	1.1	1.3	1.7
Handedness (chirality/laterality): Left-handed	0.6	0.8	4.8	0.5	-0.8	-0.0	-0.5	0.6	0.9	-2.2	-0.0	0.4	1.1	0.3
Mood swings	0.9	1.6	4.0	-2.0	-1.5	-1.7	-1.3	-0.6	-0.9	-1.6	-1.3	-0.6	-0.8	-0.9
Loneliness, isolation	0.1	0.1	0.4	0.1	-0.5	0.5	-0.2	-0.3	-0.1	0.2	-0.2	-0.7	-0.4	0.3
Long-standing illness, disability or infirmity	0.7	1.1	3.3	-0.6	-0.9	-1.7	-1.1	-0.5	-0.9	-0.7	-0.9	-1.8	-0.9	-0.8
Ever had bowel cancer screening	0.1	0.1	0.2	0.3	-0.4	-0.1	-0.4	-0.1	-0.0	0.0	-0.5	-0.3	-0.4	-0.5
Diabetes diagnosed by doctor	0.2	0.3	1.1	-0.6	0.3	0.9	0.2	0.9	-0.1	1.1	-0.0	-0.1	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	3.8	-1.5	-1.9	-0.8	-2.0	-0.5	-1.7	-1.6	-1.5	-1.5	-1.6	-0.7
Friendships satisfaction	0.7	0.9	3.6	0.1	-1.2	-1.2	-0.9	0.3	-0.0	-1.9	-1.6	0.1	-0.0	-0.3
Qualifications: nursing, teaching	0.3	0.5	1.7	-0.1	0.4	1.3	0.6	-1.2	-0.0	0.4	-0.0	1.3	-0.2	0.5
Commuting to job workplace: Walk	1.1	1.2	3.8	0.8	1.0	2.0	1.1	1.1	0.9	0.3	1.4	0.2	0.7	1.6
Eye problems/disorders: Cataract	0.3	0.3	1.5	0.4	0.2	0.5	0.5	-0.7	-0.0	-0.6	-0.5	1.2	-0.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.6	-1.2	0.2	0.1	0.1	-1.3	0.0	-0.6	-0.3	-0.0	-0.0	0.2
Medication for cholesterol	1.5	2.3	4.8	1.0	0.7	1.0	1.6	1.2	2.2	-0.7	1.6	1.9	2.1	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.2	0.6	-0.1	-0.8	-0.1	0.6	0.3	-1.1	-0.2	0.4	0.6	0.1
Back pain experienced in last month	0.6	0.9	4.0	-1.9	0.3	-2.0	-0.4	0.7	-0.5	0.5	0.5	-0.4	-0.2	-0.7
Mineral and other dietary supplements	1.3	1.7	3.6	0.8	1.9	1.9	1.6	0.4	1.4	0.4	0.9	0.6	1.5	1.6
Breast cancer (self-reported)	2.8	3.4	7.7	0.1	2.2	2.8	2.2	2.1	1.5	1.6	2.2	1.5	1.0	1.5
Asthma (self-reported)	0.5	0.9	2.8	0.4	1.0	1.3	0.5	-1.7	-0.1	1.5	0.5	-1.1	0.1	0.9
Osteoporosis (self-reported)	0.7	0.9	2.8	0.2	-1.3	-0.5	-0.9	0.3	-1.2	-0.1	-0.9	-1.0	-1.7	-0.9
Osteoarthritis (self-reported)	0.3	0.4	1.1	-0.7	0.1	0.7	-0.3	0.5	-0.6	0.7	0.4	-1.0	-1.1	-0.0
Medication: Aspirin	1.9	2.5	10.8	-0.4	-0.7	-1.6	-1.6	-0.8	-2.0	1.1	-0.8	-3.3	-1.9	-0.9
Medication: Gliclazide	0.6	0.6	2.8	0.6	0.8	1.7	0.8	0.7	0.8	0.3	0.6	0.2	0.4	0.9
Illnesses of father: None of the above (group 1)	2.2	2.7	6.1	-1.9	-2.0	-1.6	-2.0	-0.3	-1.5	-0.3	-1.9	-0.9	-1.6	-2.5
Smoking status: Current	1.4	2.3	5.9	-1.6	-1.7	-2.4	-1.8	0.7	-1.2	-1.4	-1.4	-0.7	-0.7	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	2.0	0.4	-0.3	-0.7	-0.6	-0.1	0.1	-1.4	-0.1	-0.7	0.3	-0.4
Whole body water mass	0.0	0.2	1.1	-0.3	0.7	0.3	0.4	0.3	0.2	1.1	-0.1	0.4	0.2	0.1
Leg predicted mass (right)	0.0	0.1	0.6	-0.8	0.5	-0.2	0.1	0.2	0.0	0.5	-0.4	0.1	0.1	-0.1
Arm fat mass (left)	0.4	1.5	3.1	-1.2	-0.7	-1.2	-1.4	0.2	-1.8	0.4	-1.3	-1.5	-1.5	-1.5
Number of self-reported non-cancer illnesses	1.0	1.8	5.9	-1.3	0.3	-0.3	-0.6	-1.5	-1.3	2.0	-1.0	-2.4	-1.4	-0.8
Average weekly champagne plus white wine intake	1.4	1.9	4.5	-0.9	-1.3	-2.1	-1.4	-1.1	-1.7	-0.5	-1.3	-1.0	-1.6	-1.4
Miserableness	0.1	0.2	0.5	-0.7	-0.2	-0.7	0.3	0.2	0.1	-0.4	-0.2	0.6	0.2	-0.0
Guilty feelings	2.4	3.6	6.7	-2.3	-1.8	-1.9	-1.9	-2.0	-1.9	-0.3	-2.4	-0.7	-1.9	-2.6
Wears glasses or contact lenses	0.6	0.7	4.0	-1.5	-0.1	0.6	-0.2	-2.0	-0.3	-0.3	-0.6	-0.3	-0.5	0.2
Ever taken oral contraceptive pill	1.4	1.6	3.9	0.2	1.7	0.3	1.1	-0.4	2.0	-0.3	1.3	0.5	1.9	1.9
Hearing aid user	0.6	0.7	3.5	0.8	-1.1	-0.7	-0.9	0.4	-0.1	-1.9	-0.5	-0.5	-0.1	-0.0
Mother’s age at death	0.8	1.0	2.2	1.0	0.4	0.7	0.9	1.4	0.9	0.1	0.6	1.5	1.4	0.9
Financial situation satisfaction	0.4	0.4	2.1	-0.7	-0.5	0.7	-0.3	-0.7	0.0	-1.4	-0.7	0.5	-0.1	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.1	1.0	-0.2	0.4	-0.4	-0.1	-0.2	-0.4	-0.1	-1.0	-0.1	0.0
Commuting to job workplace: Public transport	0.7	0.8	3.6	0.7	-0.0	1.9	0.8	0.2	0.2	-0.1	1.2	0.1	0.7	1.4
Eye problems/disorders: Glaucoma	1.5	1.8	5.6	2.4	1.2	1.2	1.4	-0.1	1.6	0.7	0.8	1.4	1.3	1.6
Medication: Blood pressure	2.2	4.2	9.1	-2.0	-1.5	-1.3	-1.8	-0.9	-2.8	1.4	-2.2	-2.2	-3.0	-2.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-0.7	-1.2	-1.1	-1.3	0.6	-0.9	-0.7	-0.9	-1.0	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.6	-0.0	-1.4	-1.9	-1.1	0.1	-0.4	-0.9	-0.3	-0.2	-0.4	-0.5
High cholesterol (Self-reported)	0.4	0.7	5.3	0.5	0.7	0.8	0.2	0.1	-0.7	2.3	0.1	-0.8	-0.5	0.0
Medication: Bendroflumethiazide	0.6	1.0	2.9	-1.7	-0.6	-0.4	-0.8	0.4	-0.9	0.7	-0.8	-1.0	-1.1	-1.3
Medication: Paracetamol	0.4	0.6	3.8	-0.2	-0.8	-0.3	-0.6	0.3	0.1	-1.9	-0.5	-0.9	0.1	0.5
Medication: Lisinopril	0.3	0.4	1.6	-0.1	0.6	0.6	0.6	1.3	0.2	0.0	1.0	0.5	-0.0	0.6
Medication: Atorvastatin	0.3	0.4	1.1	0.4	1.1	0.8	0.7	0.8	0.7	0.6	0.4	-0.0	0.6	0.5
Illnesses of father: High blood pressure	0.4	0.5	1.2	-0.1	0.9	0.9	1.0	-0.2	0.3	1.1	0.8	0.7	0.5	0.4
Alcohol drinker status: Never	1.8	2.1	5.6	-1.0	-1.3	-0.8	-1.5	-1.6	-1.8	0.8	-0.9	-2.4	-1.9	-1.0
Ever smoked	0.4	0.7	3.6	-1.3	0.1	-1.1	-0.4	1.9	-0.1	0.0	0.0	-0.2	0.6	-0.6
Basal metabolic rate	0.0	0.2	1.0	-0.4	0.5	-0.0	0.1	0.3	-0.1	1.0	-0.3	0.1	-0.1	-0.3
Leg fat percentage (left)	0.3	1.1	3.5	-0.9	-0.8	-1.9	-1.0	1.4	-1.1	-1.0	-0.7	-0.8	-0.8	-1.0
Arm fat-free mass (left)	0.1	0.3	1.0	0.1	1.0	0.5	0.7	0.5	0.4	1.0	0.3	0.5	0.4	0.4
Number of operations (self-reported)	0.7	1.0	3.2	-1.4	1.0	0.7	0.1	-1.8	-0.7	1.8	-0.3	-0.4	-0.6	-0.6
Average weekly beer plus cider intake	0.4	0.5	2.0	0.0	-0.3	-0.5	-0.9	-0.5	-1.0	0.6	-0.4	-1.4	-0.9	-0.6
Irritability	1.2	2.0	4.2	-0.8	-1.6	-1.0	-1.6	-1.4	-1.8	-0.2	-1.3	-2.0	-1.7	-1.2
Risk taking	0.8	1.1	3.1	-0.0	1.6	0.5	1.1	0.2	1.8	-0.2	1.1	0.9	1.3	1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	6.0	0.2	-0.7	-0.6	-0.4	0.2	0.1	-2.5	-0.3	0.8	0.4	-0.8
Fractured/broken bones in last 5 years	0.4	0.6	3.1	-0.3	-0.4	1.0	0.0	-1.8	0.3	-1.0	-0.7	0.0	0.1	0.6
Age started oral contraceptive pill	2.0	2.5	5.1	1.8	2.0	1.5	1.6	0.3	1.5	2.3	2.1	-0.2	0.8	1.5
Diastolic blood pressure, automated reading	0.1	0.4	1.1	-0.6	0.1	0.8	-0.3	0.4	-0.8	1.1	0.1	-0.8	-1.0	-0.4
Ever depressed for a whole week	2.0	2.4	4.9	-1.5	-1.1	-1.2	-1.6	-0.7	-1.6	0.8	-2.1	-2.2	-1.7	-1.7
Unable to work because of sickness or disability	3.0	3.8	12.2	-1.9	-1.6	-3.5	-2.3	-1.1	-1.7	-1.1	-1.9	-2.2	-1.5	-1.6
Commuting to job workplace: Cycle	1.0	1.2	2.9	-0.2	-1.5	-0.5	-1.0	-0.7	-1.6	0.4	-1.2	-0.5	-1.7	-1.3
Myopia	1.1	1.6	5.3	-2.3	-0.4	0.0	-1.0	-2.1	-1.2	0.8	-1.1	-1.1	-1.4	-0.8
Vascular/heart problems diagnosed by doctor	1.1	3.0	5.7	1.9	1.1	1.2	1.4	1.3	2.1	-1.7	1.8	2.1	2.4	1.6
Cholesterol lowering medication	1.1	1.7	2.8	-1.7	-0.3	-1.0	-1.4	-1.0	-1.4	0.7	-1.6	-1.5	-1.5	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	2.2	-1.5	-0.0	-0.7	-0.3	-0.4	-0.4	-0.3	-0.5	-0.1	-0.4	-0.3
Pain experienced in last month	1.7	2.8	10.5	3.2	1.2	2.8	1.5	0.6	0.7	1.7	1.3	1.4	0.5	1.1
Supplements: Calcium	0.3	0.3	1.0	0.6	-1.0	-0.2	-0.7	-0.4	-0.8	0.0	-0.3	0.0	-0.4	-0.5
Basal cell carcinoma (self-reported)	1.6	1.9	4.4	0.1	1.4	1.6	1.4	2.1	0.5	2.0	1.4	1.7	0.8	0.4
Heart attack/myocardial infarction (self-reported)	1.9	2.4	7.8	-0.7	-0.6	-2.8	-1.6	-1.2	-1.4	0.5	-0.9	-2.4	-1.5	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.8	0.4	-0.7	1.2	-0.2	1.3	-0.7	0.4	-0.2	-1.1	-1.0	0.4
Heart disease (siblings)	0.4	0.5	1.8	0.2	0.8	-0.0	0.4	1.3	0.3	0.8	0.7	0.9	1.0	0.3
Alcohol drinker status: Previous	1.1	1.3	3.9	-1.4	-0.7	-1.1	-0.9	-2.0	-0.9	-0.2	-1.4	-0.8	-1.3	-0.9
Pack years of smoking	0.7	1.0	2.5	-1.6	-0.7	-1.4	-1.1	0.1	-0.7	-0.7	-1.3	-0.9	-0.9	-1.0
Impedance of whole body	0.1	0.5	2.0	0.3	-1.2	-0.5	-0.7	-0.5	-0.5	-1.4	-0.5	0.0	-0.4	-0.5
Leg fat mass (left)	0.2	0.8	1.8	-0.8	-0.5	-1.3	-1.0	0.9	-1.1	-0.3	-0.9	-0.9	-0.9	-1.0
Arm predicted mass (left)	0.0	0.1	0.7	-0.2	0.6	0.1	0.4	0.2	0.1	0.9	0.0	0.3	0.2	0.1