Hub : Genes

TRIM68

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.3233 0.1118 5.4e-03 0.065 NA 0.025 NA 0.060 2.3e-03 NA 4.3e-02 NA 3.3e-03
2 GTEx Artery Tibial 0.1501 0.0409 8.9e-05 0.040 NA 0.098 NA 0.082 4.1e-04 NA 4.5e-08 NA 5.7e-07
3 GTEx Brain Cerebellar Hemisphere 0.3520 0.1090 1.3e-03 0.241 NA 0.158 NA 0.185 7.1e-07 NA 7.3e-05 NA 1.7e-05
4 GTEx Brain Cerebellum 0.2780 0.0860 1.5e-03 0.107 NA 0.104 NA 0.152 4.6e-04 NA 5.7e-04 NA 3.0e-05
5 GTEx Esophagus Muscularis 0.2420 0.0660 4.1e-04 0.096 NA 0.039 NA 0.089 2.0e-06 NA 1.9e-03 NA 4.5e-06
6 GTEx Skin Sun Exposed Lower leg 0.1500 0.0450 3.5e-04 0.035 NA 0.021 NA 0.036 6.5e-04 NA 6.3e-03 NA 5.9e-04
7 GTEx Testis 0.2270 0.0640 6.0e-04 0.105 NA 0.107 NA 0.117 2.3e-05 NA 1.8e-05 NA 7.7e-06
8 GTEx Thyroid 0.2760 0.0630 1.3e-06 0.023 NA 0.063 NA 0.044 6.8e-03 NA 1.4e-05 NA 2.6e-04
9 GTEx Whole Blood 0.0920 0.0350 1.9e-03 0.022 NA -0.003 NA 0.008 3.8e-03 NA 8.4e-01 NA 5.0e-02
10 METSIM Adipose 0.0687 0.0203 1.2e-06 0.056 0.040 0.056 0.045 0.064 8.0e-09 9.6e-07 7.7e-09 2.4e-07 6.2e-10
11 NTR Blood 0.0333 0.0119 6.6e-04 0.025 0.005 0.021 0.024 0.020 1.2e-08 6.6e-03 1.7e-07 2.0e-08 2.7e-07
12 TCGA Prostate Adenocarcinoma 0.1547 0.0443 3.1e-15 0.197 0.148 0.174 NA 0.189 2.8e-20 3.0e-15 8.0e-18 NA 2.0e-19
13 TCGA Thyroid Carcinoma 0.0700 0.0300 2.9e-03 0.003 0.020 0.029 NA 0.003 1.5e-01 4.4e-03 7.6e-04 NA 1.5e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.3 0.5 3.2 0.2 0.5 0.2 0.3 0.2 -0.5 0.6 0.4 -1.1 -0.4 0.0 -1.8 -1.0
Bipolar Disorder or Schizophrenia 0.2 0.5 1.0 -0.7 0.0 0.5 0.7 0.8 -0.5 0.6 -0.6 -1.0 -0.5 0.8 -0.9 0.5
Depressed Affect (Nagel 2018) 1.0 2.1 7.2 -1.9 -0.7 2.7 1.6 -1.8 -0.2 -0.9 -1.1 0.9 0.0 -1.8 -1.3 -1.5
Depression (Nagel 2018) 0.8 1.2 2.8 -1.4 -0.6 1.7 0.3 -1.6 -0.0 -0.9 -1.3 0.5 -0.4 -1.6 -0.9 -0.9
Intelligence (Savage-Jansen 2018) 0.5 1.6 4.9 -0.5 2.2 0.6 -0.3 1.2 1.9 1.7 0.9 1.4 -0.8 1.1 1.4 0.5
Neuroticism (Nagel 2018) 0.9 2.2 7.1 -1.6 -1.0 2.7 1.8 -2.0 -0.3 -1.3 -0.2 1.0 0.0 -1.9 -1.4 -1.2
Schizophrenia (2018) 0.3 0.6 2.2 -1.1 -0.4 0.5 0.7 1.0 -0.2 0.3 -1.2 -0.4 -0.4 1.0 0.3 1.5
Schizophrenia vs Biploar Disorder 2.5 3.3 10.2 -1.2 2.1 -0.1 0.2 2.4 2.5 2.2 0.8 0.8 -0.6 2.4 3.2 1.6
Worry (Nagel 2018) 0.8 1.7 4.9 -0.4 -1.2 2.2 1.0 -1.7 -0.7 -1.2 -0.2 0.7 0.5 -1.6 -2.2 -1.3
Alzheimer’s Disease (in mother) 0.4 0.4 1.7 -0.7 -0.1 0.1 0.5 0.6 -1.1 -0.4 0.5 -1.0 -0.0 0.6 0.2 1.3
Alzheimer’s Disease (in father) 1.0 1.0 3.9 0.3 1.6 -0.3 -1.2 1.3 0.5 1.3 0.1 -2.0 -0.1 1.2 -0.5 -0.3
Alzheimer’s Disease (including proxy) 0.4 0.6 3.0 0.0 0.7 -0.3 -0.1 1.1 -0.3 0.5 0.7 -1.7 0.1 1.0 -0.1 1.0
Crohns Disease (2017) 0.2 0.5 1.3 -1.1 -0.4 0.1 1.0 -0.3 -0.8 -0.0 -0.8 -0.4 -1.1 -0.3 -0.9 -0.1
Irritable Bowel Disease (IBD) 0.4 0.9 5.1 0.1 1.0 2.2 1.7 0.7 0.7 1.0 -0.6 -0.2 -0.1 0.8 -0.3 -0.2
Ulcerative Colitis (UC) 1.6 3.0 9.9 1.0 2.7 3.1 1.3 2.0 2.2 2.3 0.4 -0.2 0.6 2.1 0.6 -0.2
Major Depression (MDD) 0.4 0.4 1.2 -1.0 -0.8 0.5 0.5 -0.7 -0.0 -0.8 -0.7 1.1 0.5 -0.6 -0.2 0.1
Reaction Time 0.7 1.4 4.7 -0.4 -0.4 -2.0 -0.8 -1.7 -0.6 -1.0 -2.2 0.4 0.7 -1.6 0.2 -1.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.7 -0.0 1.1 -0.3 0.1 0.8 0.3 0.8 1.3 0.9 -0.7 0.8 -0.1 0.2
Breast Cancer 0.9 2.2 4.9 0.3 1.9 -0.0 0.9 1.8 1.8 2.2 1.8 1.4 -1.0 1.9 1.0 -1.5
Ovarian Cancer 0.4 0.5 1.4 -0.6 0.1 -0.9 -0.6 1.1 0.4 1.1 -0.4 -0.0 0.5 1.2 0.6 0.3
Prostate Cancer 0.8 1.1 5.0 1.3 0.5 1.7 2.2 0.8 0.7 0.2 0.6 -1.0 0.3 0.7 0.7 0.7
Age at First Birth 0.4 0.6 1.5 0.3 1.2 -0.2 -0.8 0.8 1.2 1.1 0.5 0.5 0.4 1.0 0.6 -0.3
Bipolar Disorder (2011) 0.8 0.8 2.6 -0.3 -1.1 1.0 0.8 -0.7 -1.1 -1.0 -0.5 -1.1 -0.1 -0.7 -1.6 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 0.0 -0.9 -0.0 -0.1 -0.7 -1.0 -0.9 -0.3 -0.7 0.6 -0.7 -0.8 0.3
Coronary Artery Disease (CAD) 0.5 0.6 1.6 1.1 0.4 -1.2 -0.3 -0.4 -1.1 -0.2 0.5 -0.9 -0.0 -0.5 -1.3 0.2
Crohns Disease (2012) 0.3 0.5 2.2 -1.5 0.2 -0.8 1.2 0.3 -0.5 0.5 -0.4 -0.6 -0.0 0.1 -0.8 -0.3
Mean Putamen Volume 0.7 0.8 3.9 -0.1 0.7 2.0 0.9 1.0 0.4 1.0 1.2 -0.9 -0.3 0.7 -0.5 -0.8
Fasting Glucose 0.6 0.8 2.4 1.6 0.1 0.2 0.2 1.2 -0.2 0.4 -1.4 -0.5 1.4 1.0 -0.6 -0.7
HbA1C 0.4 0.4 2.1 -0.1 0.3 -1.0 -1.5 0.6 -0.4 0.6 0.3 0.4 -0.9 0.5 -0.4 -0.1
HDL Cholesterol 0.4 0.7 1.8 -0.5 1.1 0.6 -0.0 1.2 1.0 1.0 0.0 0.5 0.2 1.3 1.1 0.6
LDL Cholesterol 0.7 1.2 2.3 1.4 1.4 1.1 0.6 0.9 1.3 1.5 -1.0 0.4 1.0 0.8 -0.2 -1.4
Lupus 0.5 0.7 4.7 -0.2 -0.4 -0.3 1.2 -0.6 -0.0 -0.7 0.3 -2.2 0.6 -0.5 0.8 0.6
Neuroticism (2016) 1.2 1.7 4.6 -0.0 -2.2 -0.8 -0.5 -2.0 -1.6 -1.6 0.4 1.1 -0.1 -1.9 -1.1 -1.2
Primary Biliary Cirrhosis 0.6 0.9 3.1 -0.5 -0.8 0.1 -0.8 -0.2 -1.5 -0.2 -1.4 -1.2 0.5 -0.2 -1.8 -0.9
Rheumatoid Arthritis 0.5 0.7 2.3 0.1 1.0 0.2 0.1 0.0 1.4 1.3 1.4 0.4 0.0 0.0 -0.1 -1.5
Schizophrenia (2014) 0.4 0.9 3.3 -1.4 0.1 0.8 1.1 1.2 0.3 0.5 -1.2 0.1 -0.3 1.2 0.3 1.8
Triglycerides 0.4 0.6 2.3 0.7 0.1 -0.2 -0.1 1.5 -0.5 0.9 0.4 -1.0 -0.3 1.5 -0.4 0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.7 -0.7 -0.3 -0.4 0.6 0.3 -0.2 0.2 0.4 -0.7 0.1 0.2 -1.3 -0.8
Ulcerative Colitis 1.0 1.4 5.6 0.7 1.4 2.4 1.2 1.1 1.7 1.1 -0.2 -0.2 1.2 1.2 0.3 -0.2
Blood Eosinophil Count 0.6 4.3 9.2 0.2 -2.6 1.6 2.4 -2.7 -2.2 -3.0 -2.3 -0.0 1.2 -2.6 -1.4 -1.8
Blood Platelet Count 0.3 3.0 9.3 0.2 -3.0 0.8 1.4 -2.7 -1.9 -2.8 0.7 0.5 -0.0 -2.7 -0.4 -0.0
Blood Red Count 0.4 4.1 11.2 1.4 -2.0 1.8 2.1 -2.0 -0.7 -2.2 -3.0 -0.1 3.4 -1.9 0.3 -2.5
Blood White Count 0.5 3.4 9.7 -0.6 -2.2 2.2 3.1 -2.7 -1.0 -2.5 -0.8 -0.5 -1.2 -2.5 -0.9 -0.2
Heel T-Score 0.3 2.7 13.3 -0.7 -1.7 0.1 -1.1 -1.4 -2.1 -1.7 -3.6 -1.5 0.3 -1.5 -1.4 -0.9
BMI 0.6 3.3 9.7 0.6 -2.7 0.4 0.7 -2.3 -2.2 -3.1 -1.9 -1.3 1.4 -2.4 -0.7 -1.0
Height 0.6 10.8 27.6 2.4 4.9 -1.1 0.6 5.2 4.3 5.0 1.4 2.0 1.7 5.2 1.6 0.4
Waist Hip Ratio (WHR) 0.2 0.9 2.9 1.7 -0.2 1.5 1.1 0.5 -1.3 0.2 0.7 -1.0 0.5 0.3 -0.9 -0.4
Systolic Blood Pressure 0.0 0.2 1.8 0.5 -0.4 1.4 0.3 -0.1 0.1 -0.4 -0.2 0.1 -0.5 -0.2 0.3 0.1
Smoking Status 0.9 2.0 10.3 -1.9 -0.5 -0.8 -1.2 0.4 -2.1 0.5 1.1 -0.9 -1.3 0.5 -3.2 -1.3
Allergy or Eczema 0.7 1.8 4.7 -0.5 -1.6 0.9 -0.2 -2.1 -1.2 -1.7 -1.0 -1.2 -0.0 -2.2 -1.7 -1.0
Cardiovascular Disease 1.0 3.3 10.8 0.7 -2.7 1.6 0.4 -2.7 -1.4 -3.3 -1.7 -0.9 0.2 -2.8 0.6 -0.7
Hypothyroidism (self reported) 0.4 0.9 3.8 -1.0 -0.5 -0.6 0.3 -1.9 -0.2 -1.2 0.0 -1.0 -0.3 -1.9 -0.3 -0.6
Respiratory disease 0.6 1.4 4.2 -1.3 -2.0 0.3 0.1 -1.4 -1.5 -1.6 -0.1 -0.6 -1.2 -1.3 -1.2 0.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.0 0.7 -0.3 0.5 0.2 -0.8 -0.2 -0.7 0.2 -1.0 0.1 -1.0 -0.4 -0.8
Lung FEV1/FVC ratio 0.1 0.4 1.5 0.3 0.8 0.1 -0.0 1.2 0.4 1.1 0.3 -0.1 -0.4 1.1 -0.4 0.4
Lung FVC 0.2 1.1 4.6 0.4 0.7 -1.5 -1.0 0.5 1.0 0.1 -0.8 -1.8 0.2 0.4 2.1 0.8
Neuroticism 1.0 2.5 5.8 -1.4 -1.8 2.0 1.3 -2.4 -1.3 -1.8 0.2 1.2 -0.1 -2.3 -1.6 -1.4
Chronotype (morning person) 1.0 2.3 10.4 -1.9 1.6 -0.4 -0.4 1.5 1.0 1.3 1.0 -0.4 -2.0 1.5 1.2 3.2
Hair Pigment 0.0 1.1 2.8 -1.7 -0.5 -1.4 -1.0 -1.1 -1.1 -0.9 0.4 -0.2 -1.7 -1.2 0.5 0.7
Tanning 0.1 1.0 6.0 1.3 -0.3 0.3 -0.1 0.2 0.6 -0.4 -1.1 -1.2 2.4 0.2 1.1 -0.1
Hand grip strength (left) 0.3 0.7 2.8 0.7 0.2 0.9 -0.1 0.2 1.7 -0.1 -0.5 1.6 1.1 0.2 1.0 -0.5
Number of treatments/medications taken 0.7 1.3 2.9 0.2 -1.5 -1.5 -1.7 -1.1 -1.7 -1.4 0.1 0.9 0.3 -0.9 -1.1 -0.3
Average weekly spirits intake 1.3 1.7 4.6 -1.7 -0.9 -2.0 -2.1 -0.4 -1.8 -0.3 0.6 -0.2 -1.5 -0.2 -1.4 0.9
Sensitivity / hurt feelings 0.8 1.4 4.0 -0.7 -1.0 2.0 1.4 -1.9 -0.2 -1.4 -0.7 -0.5 0.5 -1.8 -0.1 -1.1
Frequency of depressed mood in last 2 weeks 0.9 1.3 4.7 -0.3 -0.6 0.7 0.4 -1.9 -1.2 -0.8 -0.7 0.2 -0.2 -1.9 -1.0 -2.2
Hearing difficulty/problems: Yes 1.3 1.9 4.2 -1.9 -2.1 1.2 0.9 -1.7 -0.5 -1.8 0.6 -0.9 -2.0 -1.8 -0.6 0.1
Relative age of first facial hair 0.8 1.7 6.8 1.4 0.9 0.8 -0.9 1.4 1.5 0.8 -0.9 -0.3 1.9 1.3 2.6 -0.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.5 -0.3 -0.6 -0.1 0.2 -1.2 -0.7 -0.9 0.6 -0.8 -0.2 -1.2 0.2 -1.1
Ever used hormone-replacement therapy (HRT) 0.2 0.2 1.0 -0.9 -0.7 0.2 -0.3 0.2 -1.0 0.1 -0.1 -0.3 -0.2 0.2 -0.5 0.2
Ever had hysterectomy (womb removed) 0.9 1.0 5.6 -1.4 -0.9 0.4 -0.0 0.9 -1.0 -0.2 0.1 -0.3 -1.2 1.0 -0.6 2.4
Systolic blood pressure, automated reading 0.1 0.2 0.6 -0.1 -0.4 0.2 -0.4 0.3 0.5 -0.3 -0.8 0.1 -0.1 0.3 0.7 0.4
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 7.5 2.7 1.5 -1.0 1.0 -0.3 1.3 1.2 0.8 1.0 1.1 -0.3 -0.5 -2.7
Angina 0.8 1.1 2.7 -1.4 -1.3 0.7 0.8 -0.9 -1.3 -0.4 0.2 -1.3 -0.9 -0.8 -1.6 -0.8
Medication for hormone replacement therapy 1.1 1.3 4.2 0.1 1.6 0.3 0.6 1.8 0.7 2.0 1.4 0.2 -0.1 1.8 -0.3 -0.2
Vitamin and mineral supplements 0.5 0.7 1.2 -0.2 1.1 0.9 0.8 0.9 0.9 1.0 0.9 -1.0 -0.1 0.7 0.5 1.1
Supplements: Zinc 0.3 0.3 1.7 -0.3 0.4 -0.0 0.4 -0.1 -0.5 0.1 0.7 0.4 -1.3 -0.1 0.5 0.8
Medication: Co-codamol 1.8 2.1 7.3 -2.7 -1.0 -0.1 -0.9 -1.9 -0.3 -1.5 0.4 -0.6 -2.6 -1.8 0.0 1.0
Medication: Metformin 0.3 0.4 3.7 0.5 0.3 -0.9 -0.2 -0.0 0.4 -0.1 0.1 -1.9 -0.1 -0.3 0.3 0.5
Diabetes (father) 0.4 0.5 1.1 1.0 -0.6 0.2 0.7 -0.9 -0.6 -1.1 -0.6 0.6 0.6 -0.7 -0.1 -0.5
Diabetes (mother) 1.6 2.0 5.3 0.7 2.0 -0.5 -0.2 2.2 2.2 2.3 0.3 0.2 0.5 2.1 1.1 -0.1
Severe depression (siblings) 0.2 0.3 1.0 -0.5 -0.4 0.5 0.3 -0.2 -0.8 -0.4 -0.2 0.5 -1.0 -0.1 -0.6 0.3
Pack years adult smoking proportion 0.9 1.4 3.4 -1.0 -0.4 1.3 1.2 -0.9 -0.9 -0.1 1.3 -1.4 -1.8 -1.2 -1.8 0.3
Impedance of leg (right) 0.1 0.7 2.9 -0.9 1.4 -0.6 -0.2 0.8 0.8 1.7 -0.0 0.1 -0.3 1.0 -0.2 -0.6
Leg fat-free mass (left) 0.2 1.1 3.7 1.7 -0.9 1.0 1.4 -0.2 -0.3 -1.2 -1.3 0.5 1.9 -0.5 0.4 -0.2
Trunk fat percentage 0.1 0.6 3.7 -1.1 -1.0 0.1 0.3 -0.4 -0.4 -0.8 -1.9 -0.8 -0.2 -0.5 -0.1 -0.0
Hand grip strength (right) 0.2 0.6 4.1 0.3 0.6 0.4 0.4 0.4 1.4 0.3 0.4 2.0 -0.0 0.3 0.7 -0.4
Townsend deprivation index at recruitment 0.4 0.5 1.8 -0.5 -0.7 -1.0 -0.2 -0.2 -1.2 -0.4 1.0 -0.2 -0.6 -0.1 -1.4 0.1
Current tobacco smoking 0.4 0.7 3.1 -0.9 -0.0 0.9 0.9 0.5 -1.1 0.4 -0.3 -0.8 -1.1 0.5 -1.8 -0.3
Average weekly fortified wine intake 0.9 1.1 3.5 -1.3 -0.9 -0.4 -0.3 -1.9 -1.0 -1.1 -1.4 -0.0 0.1 -1.6 -0.3 -1.1
Maternal smoking around birth 0.5 0.7 3.9 1.1 -0.0 2.0 0.6 -0.5 0.5 -0.4 0.4 -1.3 0.9 -0.7 0.0 -0.5
Fed-up feelings 0.4 0.7 3.3 -1.8 -0.7 0.4 0.1 -1.2 -0.3 -0.8 0.5 0.7 -0.2 -1.1 -0.9 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 3.2 0.0 -0.0 1.8 1.1 -1.3 0.7 -0.7 -1.1 1.0 -0.3 -1.4 0.3 -0.9
Relative age voice broke 0.4 0.7 2.7 0.6 1.0 -0.1 0.2 0.0 1.6 0.3 0.3 0.7 0.8 0.2 1.5 -1.0
Taking other prescription medications 0.3 0.5 1.1 -0.3 -0.8 -0.2 -1.0 -0.9 0.1 -0.9 -0.8 0.9 0.2 -0.9 0.7 0.1
Age when periods started (menarche) 0.8 1.9 6.2 0.5 1.8 -0.6 -0.1 1.6 1.4 1.9 2.5 1.5 0.1 1.5 1.6 -0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.9 -0.8 -1.1 -0.2 0.0 0.3 -1.4 -0.2 -0.6 0.4 -0.9 0.3 -1.0 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 4.8 0.5 -1.8 0.2 -0.2 -1.1 -1.2 -2.2 -2.0 -0.8 0.7 -1.4 -0.0 -0.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.7 1.6 0.5 0.5 0.5 -0.3 0.6 0.5 -1.1 1.1 1.0 -0.4 0.6 -0.9
Qualifications: CSEs or equivalent 0.4 0.5 2.3 -0.3 0.4 0.7 0.3 -0.4 0.7 -0.3 1.5 1.4 0.0 -0.5 -0.0 0.7
Serious illness, injury or assault to yourself 0.2 0.2 1.2 0.4 0.0 -0.0 0.2 -0.2 -0.7 0.1 0.5 -1.1 -0.1 -0.3 -0.6 -0.4
High blood pressure 0.1 0.4 1.0 -0.3 -0.7 0.5 -0.6 -0.1 -0.4 -0.7 -0.8 -1.0 -0.7 -0.2 0.5 0.5
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.4 -0.7 -1.7 1.6 0.2 -1.8 -1.1 -1.7 -0.8 -0.9 -0.4 -1.9 -1.4 -0.3
Multivitamins +/- minerals 1.0 1.2 2.5 1.5 -1.4 -0.5 -0.4 -1.1 -1.3 -0.9 -1.4 0.3 1.0 -1.0 -1.0 -1.6
Stomach or abdominal pain in last month 1.2 1.5 7.0 -2.6 -0.3 -0.4 -0.6 -0.2 -0.7 0.0 1.4 -0.2 -2.4 -0.1 -1.5 1.0
Supplements: Glucosamine 0.4 0.6 2.1 1.0 -0.0 0.1 -1.4 -0.2 -0.8 0.0 -1.2 -1.0 0.2 -0.3 -1.0 -0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.1 -1.3 1.2 -0.5 0.0 1.2 0.1 1.8 -0.2 -1.2 -1.5 1.2 -0.9 1.3
Medication: Atenolol 0.5 0.6 2.1 -0.4 0.6 -1.3 -1.0 1.2 0.5 1.0 -0.1 -0.1 0.5 1.4 0.2 0.4
Medication: Levothyroxine sodium 0.5 0.8 2.8 0.6 -1.2 -0.8 -0.1 -1.5 -0.9 -1.1 0.2 -0.0 0.6 -1.7 -0.3 -0.9
Sitting height 0.2 1.8 6.2 2.1 1.1 0.3 0.8 1.5 1.2 0.8 -0.4 1.4 2.5 1.5 1.1 0.4
Chronic bronchitis/emphysema (father) 2.4 2.8 11.0 -0.7 1.8 1.4 -0.1 1.4 3.3 1.7 0.7 -0.3 -0.4 1.5 3.3 0.9
High blood pressure (mother) 0.6 0.8 2.2 -0.5 -0.3 0.2 1.5 0.3 -1.3 0.2 1.1 0.4 -1.4 0.3 -1.4 0.5
Body mass index (BMI) 0.4 1.7 4.7 -0.0 -2.0 0.1 -0.0 -1.5 -1.5 -2.2 -2.0 -1.2 1.0 -1.6 -0.2 -0.6
Impedance of leg (left) 0.3 1.4 5.4 -1.3 2.0 -0.7 -0.1 1.1 1.1 2.3 0.7 0.4 -1.1 1.3 -0.3 -0.2
Leg predicted mass (left) 0.2 1.0 3.6 1.7 -0.8 0.9 1.4 -0.1 -0.3 -1.1 -1.2 0.5 1.9 -0.4 0.5 -0.1
Trunk fat mass 0.1 0.6 3.6 -0.4 -1.1 0.3 0.7 -0.5 -0.4 -1.1 -1.9 -0.5 0.4 -0.6 0.0 -0.0
Waist circumference 0.1 0.5 1.7 0.4 -1.1 0.5 0.4 0.2 -1.2 -0.7 -0.9 -1.3 0.5 0.1 -0.1 0.6
Number of incorrect matches in round 1.8 2.9 11.6 -3.4 -0.6 -1.0 -2.4 -1.1 0.8 -1.1 0.6 1.1 -2.0 -0.8 1.1 3.0
Past tobacco smoking 1.2 2.2 8.3 1.5 2.0 0.4 0.9 1.0 2.9 1.1 -1.0 0.1 0.5 0.7 2.7 1.2
Alcohol usually taken with meals 0.9 1.5 5.5 0.6 -2.3 -0.0 -0.1 -1.5 -0.8 -1.9 -1.2 1.0 -0.8 -1.6 0.6 1.0
Nervous feelings 0.5 0.9 3.9 0.1 0.1 2.0 1.3 -0.8 0.7 0.1 -0.4 0.0 0.6 -0.7 -0.1 -2.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.8 -0.7 -0.1 1.4 1.0 -1.7 0.1 -0.6 -0.3 0.4 -0.1 -1.7 0.0 -1.5
Hearing difficulty/problems with background noise 1.4 2.2 6.9 -2.6 -2.3 0.7 -0.1 -1.4 -1.8 -1.8 0.7 0.0 -1.6 -1.3 -1.5 0.2
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 0.5 -0.4 0.4 0.3 -0.2 0.6 -0.2 0.5 0.4 0.0 -0.2 0.5 -0.7
Had menopause 1.1 1.3 4.0 -1.7 -1.1 -0.7 -1.8 0.2 -0.2 -0.6 -0.5 -1.7 -0.8 0.4 0.8 2.0
Had other major operations 1.2 1.5 3.7 1.7 1.3 -1.9 -1.1 0.5 0.6 1.5 -1.0 -1.2 1.6 0.6 -0.4 -1.3
Forced vital capacity (FVC) 0.0 0.2 0.7 0.8 0.4 -0.4 0.2 -0.0 0.8 -0.1 -0.3 0.4 0.2 -0.1 0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.8 -0.4 -1.1 0.5 0.1 -0.3 -0.5 -1.4 -0.5 -1.0 -0.4 -0.5 0.1 0.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.7 -0.9 0.4 1.6 1.6 0.3 0.3 -0.1 -1.2 -0.8 -0.8 0.4 0.7 0.8
Qualifications: None of the above 0.3 0.7 1.8 -0.5 0.3 -1.2 -0.0 1.3 0.9 1.3 0.3 -0.8 0.0 1.3 0.7 -0.2
Financial difficulties in last 2 years 1.0 1.3 3.2 -1.3 -1.4 0.9 1.4 -1.6 -0.6 -1.8 0.9 -0.2 -1.0 -1.6 0.2 -0.0
Mouth/teeth dental problems 0.3 0.5 1.7 0.9 1.0 -0.7 -0.2 1.3 -0.1 0.9 -0.4 0.1 0.3 1.2 0.2 0.2
Heart attack 0.5 0.7 2.5 0.7 0.7 -0.0 0.3 1.0 -0.2 1.6 -0.1 0.3 1.1 1.3 -0.9 -0.4
Allergy 0.4 0.9 2.0 0.5 1.0 -1.4 -0.7 1.3 0.5 0.8 -0.0 1.3 0.8 1.3 1.1 0.3
Pain all over the body in last month 1.2 1.3 4.3 1.1 1.6 -0.0 0.3 0.7 0.8 1.6 0.1 -2.1 1.2 0.6 -0.5 -1.7
Diabetes (self-reported) 0.4 0.6 3.0 1.7 0.9 -0.1 -0.6 -0.4 0.7 0.1 0.3 -1.4 0.0 -0.6 0.3 -0.1
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 5.7 -2.4 -1.5 -1.3 -1.7 -0.7 -2.0 -0.8 0.3 -0.3 -1.1 -0.7 -1.7 0.1
Medication: Ramipril 0.2 0.3 1.8 0.1 0.0 0.4 0.6 0.1 0.5 0.3 -0.2 -1.3 -0.7 0.1 0.4 -0.0
Medication: Simvastatin 0.7 1.0 2.8 0.0 -1.5 -0.5 0.0 -1.4 -1.0 -1.7 -0.5 0.1 1.2 -1.3 -0.1 -1.0
Fluid intelligence score 1.1 2.2 4.8 -0.2 1.7 -1.2 -1.0 2.1 1.5 1.5 1.0 1.6 -0.9 2.2 1.8 1.6
Illnesses of siblings 0.7 1.0 4.6 0.5 1.2 -0.2 -0.4 0.4 2.1 0.2 -0.5 1.2 0.2 0.5 1.9 0.9
Neuroticism score 0.9 1.9 3.9 -1.9 -1.5 1.7 1.2 -2.0 -1.4 -1.7 0.6 0.3 -0.4 -2.0 -1.1 -0.8
Weight 0.1 0.7 3.0 0.7 -1.0 0.4 0.5 -0.2 -0.6 -1.1 -1.7 -0.3 1.5 -0.4 0.2 -0.1
Impedance of arm (right) 0.2 1.0 5.5 -1.4 0.8 0.3 0.1 0.2 0.6 1.2 1.1 0.7 -2.3 0.3 -1.1 0.5
Arm fat percentage (right) 0.5 1.8 5.4 -1.1 -2.3 -0.1 -0.3 -1.6 -1.7 -2.0 -1.7 -1.0 -0.1 -1.6 -1.1 -0.2
Trunk fat-free mass 0.2 1.4 7.2 2.4 -0.1 0.4 1.1 0.7 0.4 -0.5 -0.9 0.9 2.7 0.5 1.0 0.2
Hip circumference 0.1 0.3 1.7 0.0 -0.7 -0.3 0.2 -0.1 0.1 -0.7 -1.3 0.7 0.8 -0.1 0.6 0.2
Time employed in main current job 1.0 1.1 2.7 -1.2 1.6 -0.4 0.5 1.2 0.1 1.3 1.4 -0.1 -1.4 1.3 0.4 1.0
Alcohol intake versus 10 years previously 0.4 0.7 2.2 -0.8 -0.6 1.2 1.3 0.6 -0.5 -0.8 -0.5 -0.6 0.2 0.5 0.5 1.5
Father’s age at death 1.0 1.4 6.4 -2.5 -1.4 1.4 -0.1 -1.5 -0.2 -1.4 -0.4 0.7 -0.8 -1.3 -0.0 0.4
Worrier / anxious feelings 0.6 1.1 3.8 -0.8 -1.5 -0.1 -0.1 -2.0 -0.7 -1.4 0.1 -0.1 -0.1 -1.8 -1.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.1 0.1 -0.2 1.0 0.8 -1.4 -0.6 -0.3 0.1 0.3 -0.6 -1.3 -0.9 -1.4
Falls in the last year 0.4 0.5 1.5 -1.0 -0.8 0.8 -0.4 -0.6 0.4 -0.7 0.4 1.1 -1.2 -0.6 0.2 0.5
Hair/balding pattern: Pattern 3 0.4 0.6 2.9 0.4 -0.4 -0.7 -1.0 0.1 -1.7 -0.1 1.1 -0.3 -0.3 0.2 -1.2 0.6
Number of live births 0.4 0.5 2.9 0.8 0.1 0.4 -0.0 0.4 -0.2 0.6 0.1 1.7 0.4 0.7 -1.0 -1.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.6 0.8 0.9 -0.5 -0.1 0.5 1.3 0.4 -0.1 0.8 0.2 0.4 0.6 0.0
Pulse rate 0.6 0.9 4.3 0.3 -0.4 2.1 1.9 -1.1 0.1 -0.8 0.6 0.5 0.1 -1.2 0.2 -0.0
Happiness 0.7 0.9 2.0 -1.0 -1.1 0.8 1.4 -0.7 0.8 -1.1 -1.2 -0.4 0.4 -0.7 1.4 0.4
Noisy workplace 0.4 0.5 3.4 -0.1 -0.2 0.3 0.8 0.1 -1.0 0.2 0.8 -1.8 -0.5 -0.0 -1.0 -0.4
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.6 0.0 -0.4 -0.0 0.5 -0.9 -1.1 -1.0 -0.6 1.3 -0.3 -0.9 -0.8 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.9 -1.3 0.1 0.2 0.4 -0.9 0.6 -0.4 0.5 -0.3 -0.5 -0.8 -0.4 -1.4
Mouth/teeth dental problems: Dentures 0.6 1.0 3.5 -0.2 1.4 0.5 -0.1 1.3 1.3 1.9 0.4 -0.7 -0.0 1.4 0.5 -0.6
Asthma 0.4 0.8 2.2 -1.1 -1.5 0.2 0.5 -1.1 -1.1 -1.1 0.4 -0.5 -1.3 -1.0 -0.1 0.5
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.2 6.2 0.5 -0.9 1.3 2.3 -1.6 -0.5 -0.9 0.3 -1.5 0.7 -1.7 -2.1 -2.5
Medication: Cholesterol lowering 0.3 0.5 1.8 -1.2 -0.8 -1.3 -0.7 -0.5 -0.6 -0.7 0.6 -0.6 -0.4 -0.3 0.1 0.5
Depression (self-reported) 0.8 1.0 2.7 -0.9 -1.0 0.3 -0.2 -1.5 -0.6 -1.2 1.1 0.7 -1.7 -1.5 -0.5 0.1
Medication: Lansoprazole 0.2 0.3 2.0 -0.5 -0.0 -0.0 -0.5 -0.1 -0.5 -0.3 -0.2 -1.4 -0.6 -0.2 0.2 -0.1
Prospective memory result 0.7 0.9 2.2 0.9 0.8 1.0 0.4 1.5 1.2 1.4 0.4 0.9 0.2 1.4 0.1 -0.8
Lung cancer (father) 2.6 3.0 10.9 -1.2 1.1 -0.8 -0.1 3.0 0.7 1.8 1.1 -0.6 -0.5 2.9 1.4 3.3
Illnesses of mother 0.7 0.9 2.2 0.6 -0.3 -0.3 -1.4 -1.0 0.3 -1.0 -1.5 -0.6 1.1 -1.1 0.8 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 3.9 1.1 0.9 -0.3 -0.1 0.3 2.0 0.1 -0.3 0.4 0.8 0.2 1.5 0.1
Pulse wave Arterial Stiffness index 0.5 0.6 3.2 -0.5 -0.7 -0.1 -0.4 -0.5 -0.9 -0.3 -1.5 -1.8 0.4 -0.5 -0.3 0.2
Impedance of arm (left) 0.3 1.2 4.1 -1.4 1.4 -0.1 0.2 0.9 0.8 1.8 0.6 0.9 -2.0 1.0 -1.0 0.2
Arm fat mass (right) 0.3 1.2 3.3 -0.1 -1.8 0.1 0.0 -1.1 -1.1 -1.8 -1.8 -1.0 0.7 -1.2 -0.4 -0.3
Trunk predicted mass 0.3 1.5 7.3 2.5 0.0 0.5 1.2 0.8 0.4 -0.3 -0.8 1.0 2.7 0.6 1.0 0.2
Standing height 0.3 3.2 7.5 1.8 2.2 0.8 1.7 2.7 1.9 2.3 0.6 2.1 1.2 2.6 0.7 0.6
Length of working week for main job 0.7 0.7 3.1 -0.0 -0.4 -1.8 -1.5 0.6 -1.1 0.2 -0.8 -0.9 -0.3 0.4 -0.6 0.5
Exposure to tobacco smoke at home 0.4 0.4 1.2 0.3 -0.6 -0.4 -0.7 -1.1 -0.2 -0.7 0.5 0.7 0.3 -1.0 -0.4 -0.9
Breastfed as a baby 1.1 1.3 3.1 -1.8 -1.4 -0.1 -0.9 -1.2 -1.3 -1.6 0.4 0.0 -1.6 -1.3 0.0 1.1
Tense / ‘highly strung’ 0.6 0.9 4.5 -0.4 -0.3 2.1 0.9 -1.3 -0.2 -0.5 -0.3 0.1 -0.1 -1.3 -1.1 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 7.4 -1.1 -2.1 1.4 0.3 -2.6 -1.8 -2.5 -0.9 0.9 -0.1 -2.7 -1.4 -0.6
Hair/balding pattern: Pattern 4 0.1 0.2 0.7 0.2 0.3 -0.4 -0.8 0.2 0.7 0.2 -0.3 0.5 0.6 0.3 0.4 -0.2
Birth weight of first child 0.8 1.4 7.8 2.8 -0.2 0.4 1.5 -0.2 0.9 0.2 -0.5 1.6 1.5 -0.2 0.5 -1.3
Peak expiratory flow (PEF) 0.5 1.1 3.5 0.9 1.1 -0.7 -0.8 0.7 1.3 0.2 -1.1 1.9 1.0 0.8 1.5 0.2
Pulse wave reflection index 0.7 0.8 2.8 -1.3 -0.6 -1.7 -1.0 0.0 -1.3 -0.2 -1.0 -1.0 0.0 0.1 -1.0 0.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.2 -0.7 0.4 1.4 1.1 0.7 -0.2 0.5 -0.4 1.5 -0.8 0.6 -0.4 0.7
Loud music exposure frequency 0.6 0.7 2.1 -1.1 -1.0 -0.3 -0.9 -0.9 -0.2 -0.9 -0.3 1.4 -1.0 -0.8 0.1 0.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.3 0.8 1.5 0.7 -0.5 0.9 0.0 0.6 -0.8 1.1 0.9 1.0 0.5 0.9
Mouth/teeth dental problems: Bleeding gums 3.5 4.5 12.5 -0.7 -3.1 0.6 0.7 -3.5 -1.8 -3.3 -1.9 0.0 0.9 -3.5 -1.4 -1.7
Blood clot in the leg (DVT) 1.4 1.8 4.1 1.5 1.9 -0.3 0.8 1.8 0.4 2.0 1.5 -1.4 0.5 1.8 -0.9 -0.0
Medication: Paracetamol 1.4 2.3 7.8 0.0 -2.1 -0.8 0.8 -1.7 -2.8 -1.7 0.8 -0.3 -0.3 -1.5 -2.7 -0.6
Headache pain in last month 0.3 0.4 2.3 -0.1 0.3 0.7 0.8 -0.1 -0.3 -0.2 -0.1 -0.1 -1.4 -0.1 0.2 1.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.2 0.8 0.7 0.7 0.9 1.1 0.3 0.8 -0.7 -0.1 0.9 1.0 0.1 0.2
Glaucoma (self-reported) 1.4 1.7 4.5 0.8 -1.3 -1.3 -1.4 -1.2 -2.1 -1.0 -0.7 0.8 1.1 -1.3 -1.5 -1.7
Gout (self-reported) 1.5 2.0 5.0 -0.9 0.8 -1.0 -1.8 1.6 1.2 1.1 2.2 0.6 -0.9 1.7 1.4 2.2
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 3.8 -0.3 -0.8 -0.8 -0.2 -1.8 -0.3 -1.2 0.2 -0.9 0.1 -2.0 -0.2 -0.7
Medication: Amlodipine 0.5 0.6 3.2 -0.1 0.2 -1.8 -1.1 0.5 -0.3 0.3 0.7 -1.3 -0.8 0.5 -0.5 0.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.7 0.3 -0.1 1.3 0.3 0.2 -0.6 0.4 0.1 0.9 -0.1 0.3 -1.1 -1.1
Birth weight 0.2 0.5 2.4 0.5 0.3 1.1 1.6 -0.1 0.1 -0.5 0.2 0.2 1.0 -0.1 1.0 0.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 2.1 0.5 0.0 0.9 -0.4 -0.3 0.1 -0.2 0.2 0.3 0.6 -0.3 0.0 -1.4
High blood pressure (siblings) 0.2 0.3 1.2 0.0 -0.1 -0.5 -0.1 0.7 -1.1 0.5 0.4 -1.0 -0.4 0.7 -0.7 -0.1
Forced vital capacity (FVC), Best measure 0.2 0.7 3.5 1.7 0.6 0.0 0.0 0.1 1.9 -0.1 -0.5 0.0 1.0 0.0 1.1 -0.4
Body fat percentage 0.2 1.0 3.9 -1.1 -1.4 -0.0 0.2 -0.9 -0.9 -1.2 -2.0 -1.0 0.1 -0.9 -0.4 -0.3
Leg fat percentage (right) 0.5 1.8 6.2 -0.8 -1.9 -0.1 -0.1 -1.4 -1.4 -1.6 -2.5 -1.4 0.8 -1.4 -0.6 -1.0
Arm fat-free mass (right) 0.3 1.4 7.9 2.1 0.1 0.2 0.9 0.9 0.2 -0.2 -1.4 0.4 2.8 0.7 1.3 -0.1
Exposure to tobacco smoke outside home 1.3 1.8 4.8 -0.8 -0.3 -2.2 -1.8 -1.6 -1.1 -0.2 -0.6 -0.6 -0.8 -1.4 -2.0 -1.8
Comparative body size at age 10 0.3 0.8 3.2 -1.8 0.3 0.5 1.5 0.7 -0.1 0.1 0.8 -0.5 -0.3 0.7 0.6 1.4
Number of full brothers 0.7 0.9 3.3 -1.4 -0.4 -1.8 -1.5 0.9 -1.2 0.0 -0.1 -0.1 -0.3 0.7 -1.0 0.6
Worry too long after embarrassment 0.2 0.3 0.8 -0.5 -0.4 -0.9 0.1 -0.6 -0.3 -0.9 -0.2 0.3 0.7 -0.6 0.3 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.9 3.7 10.4 -2.3 -2.1 1.6 0.1 -3.1 -1.7 -2.5 -0.4 0.5 -0.6 -3.2 -1.9 -1.6
Wheeze or whistling in the chest in last year 0.4 0.7 2.2 -1.5 -0.0 1.3 0.4 0.2 -0.4 0.6 0.9 -0.1 -1.4 0.3 -1.2 -0.6
Number of children fathered 0.3 0.4 1.9 0.6 0.0 0.4 0.6 0.5 0.1 0.1 0.0 0.8 1.4 0.6 0.7 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 3.1 0.8 0.9 0.6 0.2 0.7 1.2 1.0 -0.3 1.5 1.8 0.8 0.4 -1.2
Age at first live birth 0.6 1.0 4.1 0.2 0.2 0.1 0.3 0.1 1.5 -0.4 1.9 -0.4 -0.7 0.2 1.6 2.0
Pulse wave peak to peak time 0.5 0.6 3.7 0.5 0.7 0.0 0.3 0.6 0.9 0.4 1.4 1.9 -0.4 0.6 0.2 -0.2
Health satisfaction 0.7 0.9 1.5 1.1 -0.8 1.2 1.2 -1.1 0.3 -1.2 -1.1 0.9 0.6 -1.1 0.1 -0.5
Shortness of breath walking on level ground 0.9 1.1 4.9 -0.4 1.2 0.5 -0.3 1.1 1.3 1.4 2.2 0.4 -0.9 1.2 0.1 -0.2
Qualifications: College or University degree 0.2 0.7 4.1 0.8 0.6 -0.5 0.1 0.5 0.3 0.8 1.1 2.0 -0.7 0.5 -0.6 0.5
Eye problems/disorders: None of the above 0.6 0.7 2.8 -1.7 0.1 0.5 1.0 0.2 0.6 -0.3 0.4 -0.9 -0.5 0.2 1.1 1.3
Mouth/teeth dental problems: Loose teeth 0.4 0.4 1.8 -0.5 -0.1 0.5 0.6 0.1 1.2 -0.4 0.3 0.0 -0.3 0.3 1.3 1.2
Emphysema/chronic bronchitis 1.0 1.1 2.5 -1.6 1.2 1.3 -0.3 0.9 1.3 1.5 0.4 -1.2 -0.7 0.9 0.2 0.7
Medication for pain relief, constipation, heartburn 1.5 2.5 12.5 1.2 2.1 0.6 -0.2 1.3 2.7 1.3 -0.6 1.1 0.5 1.2 3.5 0.7
Neck or shoulder pain in last month 0.6 0.9 2.2 1.3 -0.5 -1.2 -1.4 -0.8 -0.8 -0.8 -1.5 -0.3 0.8 -0.9 -0.3 -0.5
Medication: Blood pressure 0.2 0.4 1.2 -0.2 0.5 -1.1 -1.1 -0.2 0.5 0.2 0.9 0.5 -0.9 -0.0 0.3 -0.4
Angina (self-reported) 1.2 1.5 4.3 -1.7 -1.5 0.7 0.9 -1.2 -1.6 -0.5 0.2 -1.0 -1.1 -1.1 -2.1 -0.9
Migraine (self-reported) 0.6 0.7 4.9 1.1 0.6 0.6 0.4 -0.1 0.9 -0.2 0.5 -0.0 1.2 0.1 2.2 0.1
Medication: Ibuprofen 1.6 1.9 5.4 0.6 -0.8 1.4 1.9 -1.6 -0.3 -0.8 0.5 -1.6 1.0 -1.6 -1.9 -2.3
Medication: Allopurinol 1.5 2.0 6.8 -0.4 0.7 -2.0 -2.3 1.5 0.8 1.0 0.9 0.4 -0.3 1.6 1.4 2.6
Medication: Omeprazole 0.6 0.7 1.7 0.3 -1.0 0.4 0.1 -1.1 -0.3 -0.8 -1.0 -1.2 0.0 -1.2 -1.3 -0.8
Medication: Seretide 50 evohaler 0.6 0.7 2.1 -0.6 0.9 -0.8 -0.8 0.4 -0.4 1.4 0.1 1.4 -0.3 0.6 -1.2 -0.7
Mean time to correctly identify matches 0.3 0.6 2.1 -0.6 -0.7 -1.4 -0.9 -1.0 -0.9 -0.8 -1.1 0.0 0.4 -0.8 -0.1 -0.1
Heart disease (mother) 0.3 0.3 0.9 -0.1 0.5 0.7 0.1 0.5 0.6 1.0 0.6 0.5 0.0 0.5 -0.8 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.1 10.1 -2.4 0.5 0.9 1.5 1.2 0.9 0.4 3.1 0.4 -3.2 1.2 1.7 2.3
Whole body fat mass 0.2 0.8 3.6 -0.3 -1.3 0.1 0.4 -0.7 -0.6 -1.2 -1.9 -0.7 0.9 -0.7 -0.0 -0.3
Leg fat mass (right) 0.2 1.0 3.6 0.1 -1.5 0.1 0.4 -0.8 -0.9 -1.4 -1.9 -0.9 1.2 -0.9 -0.1 -0.5
Arm predicted mass (right) 0.3 1.5 8.7 2.1 0.1 0.2 0.9 0.8 0.5 -0.3 -1.4 0.4 3.0 0.6 1.4 -0.4
Pulse rate, automated reading 0.8 2.6 6.9 0.1 -2.6 0.6 0.9 -1.5 -2.6 -2.3 -0.6 -2.5 -0.5 -1.7 -0.5 1.3
Alcohol intake frequency. 0.7 1.6 3.9 -1.5 -0.9 0.7 1.8 -1.6 -0.9 -1.2 -0.6 -2.0 -1.1 -1.8 -0.2 -0.2
Comparative height size at age 10 0.2 1.0 2.5 1.1 -0.1 1.3 1.5 1.6 -0.3 0.4 -0.7 -0.3 1.2 1.4 -0.0 1.0
Number of full sisters 1.3 1.6 8.2 -0.6 1.3 -1.5 -0.9 0.9 -0.2 1.2 2.9 0.7 -1.9 0.8 -0.5 0.5
Suffer from ‘nerves’ 2.2 3.4 7.6 -1.7 -2.3 2.8 1.7 -2.5 -2.0 -2.2 -1.0 -0.2 0.4 -2.4 -1.9 -0.6
Overall health rating 0.4 0.8 2.4 -0.5 -0.1 1.6 1.3 -0.4 -0.1 -0.1 1.2 -0.7 -1.5 -0.5 -0.9 0.5
Chest pain or discomfort 0.5 0.7 3.1 -1.2 -0.5 -0.2 0.3 -0.1 -1.2 0.5 0.8 -0.6 -1.8 0.1 -1.1 0.1
Had major operations 2.4 2.8 6.9 -1.5 1.8 -0.4 0.3 2.4 1.6 1.7 0.5 -0.1 -2.0 2.5 1.5 2.6
Age at last live birth 0.6 0.9 4.3 -0.2 0.1 -0.0 0.1 0.5 0.9 -0.2 1.5 0.6 -0.6 0.7 1.7 2.1
Family relationship satisfaction 1.3 1.6 4.1 -0.2 -1.1 0.7 1.8 -1.8 0.0 -1.6 1.2 2.0 -0.4 -1.7 0.8 -0.7
Leg pain on walking 0.2 0.2 1.2 -0.3 -0.2 -0.1 0.2 -0.3 -0.3 -0.4 1.1 -0.4 -0.4 -0.3 0.7 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 5.8 0.1 0.2 2.4 0.1 -0.0 -0.5 -0.0 0.2 -0.2 -0.6 -0.1 -0.4 0.6
Commuting to job workplace: Car/motor vehicle 2.5 2.9 13.9 0.2 0.7 -2.4 -3.7 0.2 1.4 0.7 -1.5 -2.6 1.2 0.1 0.3 -2.0
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.6 1.3 0.7 -0.8 -1.3 0.7 0.5 0.4 -1.6 -0.3 1.0 0.7 0.8 0.9
Medication: Aspirin 1.2 1.6 8.0 -1.3 -1.6 0.0 0.2 -1.2 -1.9 -0.6 0.5 0.0 -0.0 -1.1 -2.8 -1.4
Supplements: Vitamin C 0.5 0.5 1.3 -0.6 -1.1 -0.9 0.3 -0.5 -0.6 -0.7 0.9 0.1 -1.2 -0.5 -0.4 0.9
Knee pain experienced in last month 1.4 2.3 6.2 -0.9 -0.9 -2.2 -2.5 -0.6 0.7 -1.2 0.9 -0.1 -1.9 -0.5 2.0 2.4
Hypertension (Self-reported) 0.1 0.4 1.1 0.2 -0.7 1.1 -0.1 -0.0 0.0 -0.6 -0.8 -1.0 -0.5 -0.1 1.0 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.2 0.2 0.2 -0.2 -0.4 0.7 -0.7 0.1 -0.5 -1.1 0.3 0.6 0.2 0.8
Illnesses of father: Heart disease 0.8 1.1 3.3 1.2 1.2 -0.7 -0.0 0.8 0.4 1.6 1.8 0.2 0.2 1.0 -0.8 -1.4
Illnesses of siblings: Diabetes 1.2 1.4 4.9 -0.8 -2.2 -1.0 -1.1 -1.0 -2.2 -1.7 -0.2 -0.0 -0.5 -1.0 -0.7 0.8
Smoking status: Previous 0.8 1.2 4.0 -0.9 -1.3 -0.8 -1.1 -0.7 -1.9 -0.5 1.4 -0.1 -0.6 -0.5 -2.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 4.0 0.4 0.1 0.9 2.0 -0.5 0.6 -0.3 -0.2 1.0 0.2 -0.6 -0.1 0.0
Whole body fat-free mass 0.2 1.2 5.7 2.2 -0.3 0.6 1.2 0.4 0.2 -0.7 -0.9 0.8 2.4 0.2 1.0 0.1
Leg fat-free mass (right) 0.1 0.7 2.7 1.6 -0.4 0.9 1.3 0.1 -0.1 -0.7 -0.8 0.8 1.4 -0.2 0.5 0.1
Arm fat percentage (left) 0.4 1.8 5.1 -1.0 -2.3 -0.1 -0.1 -1.4 -1.6 -2.0 -2.0 -0.9 0.1 -1.5 -1.0 -0.4
Average weekly red wine intake 0.4 0.6 5.4 0.2 0.0 -0.7 0.1 0.5 0.4 0.3 0.6 2.3 -0.2 0.6 0.0 0.3
Handedness (chirality/laterality): Left-handed 0.5 0.5 3.0 0.6 -0.4 0.9 0.7 -0.7 -0.5 -0.4 -1.7 0.7 0.2 -0.7 -0.4 -0.6
Mood swings 0.9 1.6 4.0 -1.3 -0.9 1.5 1.5 -2.0 -0.9 -1.0 0.6 0.0 -0.1 -2.0 -1.3 -1.5
Loneliness, isolation 0.5 0.7 3.8 -0.7 -0.5 0.8 1.3 -0.7 -0.5 -0.7 -0.5 2.0 -0.2 -0.7 0.5 0.1
Long-standing illness, disability or infirmity 2.0 3.0 7.0 -2.2 -0.8 -1.3 -2.6 -2.3 -0.7 -1.2 0.9 -2.0 -2.6 -2.4 -0.2 0.3
Ever had bowel cancer screening 0.6 0.7 3.8 -1.2 -0.2 0.6 0.8 0.2 -0.6 0.2 -0.1 0.1 -1.4 0.2 -0.8 1.9
Diabetes diagnosed by doctor 0.3 0.6 2.6 1.6 0.6 -0.6 -0.9 0.0 0.3 -0.1 -0.0 -1.6 0.5 -0.2 0.1 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.5 1.2 -0.6 -1.0 -0.2 -1.2 -0.2 -0.9 0.9 -0.2 -0.0 -1.0 -0.8 -0.6
Friendships satisfaction 0.3 0.4 2.2 0.2 -0.2 -0.1 0.5 -0.4 -0.1 -0.5 -1.5 0.1 0.7 -0.5 0.2 -1.1
Qualifications: nursing, teaching 0.2 0.3 1.0 0.4 -0.0 0.6 0.2 -0.8 -0.7 -0.3 -0.8 -0.4 0.3 -1.0 0.0 -0.7
Commuting to job workplace: Walk 0.7 0.7 3.1 -0.8 0.0 0.7 1.2 0.8 -0.5 0.2 -0.8 0.6 -0.9 0.9 0.4 1.8
Eye problems/disorders: Cataract 0.5 0.6 3.5 0.7 -0.2 -0.9 -1.9 0.7 -0.9 0.2 0.2 0.9 0.3 0.8 0.1 0.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.6 -1.6 -0.5 0.0 -0.1 -0.7 -0.6 -0.4 1.2 -0.9 -0.9 -0.7 -0.9 1.1
Medication for cholesterol 0.2 0.3 1.5 0.4 0.5 0.2 0.3 -0.4 1.2 -0.1 0.4 0.7 0.8 -0.4 0.6 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 4.5 -0.6 1.9 -1.8 -2.1 1.8 1.2 2.1 -0.1 0.9 -1.8 1.9 0.9 1.3
Back pain experienced in last month 1.6 2.3 8.9 -3.0 -1.5 -1.4 -1.4 -1.8 -1.3 -1.7 -0.1 -0.7 -1.7 -1.9 -0.6 -0.1
Mineral and other dietary supplements 0.5 0.6 2.6 -0.2 -0.1 0.2 1.6 -0.4 0.9 -0.1 0.6 -0.9 0.0 -0.5 1.5 -0.8
Breast cancer (self-reported) 0.7 0.8 3.2 -0.1 -0.1 -1.8 -1.2 0.8 -0.1 0.2 -1.4 -0.3 0.9 0.8 1.2 0.3
Asthma (self-reported) 0.4 0.8 2.0 -1.3 -1.4 -0.2 0.2 -1.0 -1.2 -1.0 0.4 -0.6 -1.3 -0.8 -0.3 0.4
Osteoporosis (self-reported) 1.4 1.7 4.0 -1.6 -1.4 -0.7 -0.1 -1.5 -1.4 -1.3 0.5 1.7 -2.0 -1.3 -1.0 1.4
Osteoarthritis (self-reported) 1.3 1.7 4.8 -2.2 -2.1 -0.6 -0.5 -1.4 -1.2 -1.9 -0.4 -0.0 -1.7 -1.3 -0.2 0.8
Medication: Aspirin 1.4 1.8 10.3 -1.0 -1.5 -0.3 -0.0 -1.2 -2.1 -0.4 0.1 0.0 0.3 -1.0 -3.2 -1.7
Medication: Gliclazide 1.2 1.4 5.4 0.6 -1.3 1.7 2.3 -1.1 -0.3 -1.6 -0.0 -1.1 0.0 -1.5 0.2 0.3
Illnesses of father: None of the above (group 1) 0.7 0.9 2.7 -1.2 -0.9 -1.6 -0.8 0.2 -1.6 -0.8 -0.7 -0.0 -0.1 0.1 0.4 1.3
Smoking status: Current 0.4 0.6 2.2 -1.0 -0.0 0.8 0.6 0.5 -1.0 0.3 -0.5 -0.9 -0.9 0.5 -1.5 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.8 0.2 0.4 -1.1 -0.6 0.9 1.7 0.3 -0.2 0.0 0.9 1.0 1.6 0.5
Whole body water mass 0.2 1.1 5.5 2.1 -0.4 0.6 1.1 0.4 0.1 -0.8 -0.9 0.7 2.4 0.1 0.9 0.1
Leg predicted mass (right) 0.1 0.8 2.8 1.7 -0.5 1.0 1.3 0.0 -0.1 -0.8 -0.8 0.9 1.4 -0.3 0.4 0.1
Arm fat mass (left) 0.3 1.2 3.9 -0.0 -1.8 0.0 0.1 -1.1 -1.1 -1.7 -2.0 -0.9 0.8 -1.2 -0.4 -0.6
Number of self-reported non-cancer illnesses 2.0 3.4 10.3 -0.6 -3.2 0.4 -0.3 -2.3 -2.5 -3.0 -1.3 -2.3 0.4 -2.4 -0.8 -0.3
Average weekly champagne plus white wine intake 0.3 0.4 1.8 -0.3 -0.7 -1.1 -0.0 -0.2 -0.4 -0.2 -0.4 1.2 -0.3 -0.2 0.4 1.3
Miserableness 1.5 2.6 6.4 -2.5 -1.3 1.0 1.4 -2.0 -1.2 -1.0 1.3 -0.1 -2.2 -2.0 -2.1 -0.9
Guilty feelings 1.0 1.5 8.8 0.2 1.7 0.7 0.7 1.2 -0.5 1.6 3.0 0.5 -0.8 1.1 -0.5 0.1
Wears glasses or contact lenses 1.0 1.2 3.8 -0.5 0.3 1.3 -0.9 1.5 0.3 1.2 -0.2 0.8 -0.6 1.6 0.9 1.9
Ever taken oral contraceptive pill 0.7 0.7 3.9 -0.2 -0.2 -0.5 -0.8 -0.6 -0.8 -0.2 -0.0 2.0 -0.1 -0.5 -1.7 -0.8
Hearing aid user 0.6 0.7 2.9 -0.4 0.2 0.8 0.2 0.2 1.4 0.2 -1.7 -0.1 -0.0 0.4 1.7 0.2
Mother’s age at death 0.4 0.5 1.5 0.3 0.5 -0.2 0.4 1.0 0.4 1.2 1.2 0.1 0.1 1.2 0.0 0.0
Financial situation satisfaction 0.7 0.8 3.0 0.7 -0.8 0.5 1.0 -0.2 0.2 -1.1 -1.5 -0.1 0.5 -0.1 1.7 1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 4.0 -0.8 -0.3 0.4 -0.9 0.7 -0.2 0.0 -0.2 -2.0 -1.1 0.6 -0.2 0.3
Commuting to job workplace: Public transport 1.2 1.5 6.1 -0.4 -0.7 2.5 2.2 -0.8 -1.2 -0.4 1.1 0.6 -1.1 -0.9 -1.3 -0.7
Eye problems/disorders: Glaucoma 0.9 1.0 3.4 0.8 -0.5 -1.5 -0.7 -0.8 -1.8 -0.3 -0.3 0.9 0.3 -0.9 -1.5 -1.3
Medication: Blood pressure 0.3 0.5 1.9 0.4 -1.3 -0.9 -0.5 0.1 -1.3 -0.6 -1.4 -0.7 0.0 0.0 -0.0 0.0
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.3 -0.4 -1.8 -0.5 0.4 -1.5 -0.9 -1.7 1.0 -0.3 -0.6 -1.4 -0.3 -0.1
Supplements: Fish oil (including cod liver oil) 1.1 1.4 5.5 -0.1 0.1 -1.4 -2.3 1.5 -1.2 0.7 -0.3 0.8 0.2 1.7 -1.2 1.4
High cholesterol (Self-reported) 0.7 1.2 2.6 -1.3 -1.4 -0.9 -0.3 -1.6 -0.9 -1.5 0.8 1.3 -0.7 -1.4 -0.2 0.5
Medication: Bendroflumethiazide 0.5 0.8 3.4 -1.8 0.4 -0.1 -0.9 -0.1 0.2 -0.2 -0.4 0.5 -1.7 0.0 0.6 1.3
Medication: Paracetamol 1.9 2.9 9.3 1.2 -2.0 -1.1 0.6 -1.9 -3.0 -1.8 0.6 -0.5 0.6 -1.8 -3.0 -1.3
Medication: Lisinopril 0.8 1.0 3.5 -0.5 -0.5 0.8 0.2 -1.9 -0.6 -1.3 -1.1 0.9 -0.9 -1.8 -0.3 -0.9
Medication: Atorvastatin 1.1 1.3 6.3 -0.3 -0.1 -2.0 -2.5 0.6 0.6 0.6 -0.5 -2.3 0.0 0.7 0.3 0.3
Illnesses of father: High blood pressure 0.7 0.8 3.0 1.7 0.2 0.7 0.5 -0.7 0.8 0.3 0.4 1.4 1.0 -0.5 -0.4 -1.5
Alcohol drinker status: Never 1.0 1.2 3.6 -0.9 0.2 0.4 1.4 0.5 1.9 0.4 1.7 0.4 -1.5 0.4 1.7 0.9
Ever smoked 2.4 4.2 15.8 -1.8 -2.7 0.8 0.5 -1.6 -3.8 -1.9 1.0 0.3 -0.3 -1.6 -4.0 -1.8
Basal metabolic rate 0.2 1.0 4.8 1.8 -0.6 0.5 1.0 0.1 -0.1 -0.9 -1.3 0.5 2.2 -0.1 0.7 -0.1
Leg fat percentage (left) 0.4 1.5 4.2 -1.3 -1.8 -0.1 0.1 -1.4 -1.4 -1.5 -2.0 -1.2 -0.0 -1.4 -0.6 -0.7
Arm fat-free mass (left) 0.2 1.1 6.0 1.8 -0.4 0.5 1.0 0.1 -0.3 -0.7 -1.4 0.3 2.4 -0.0 0.6 -0.5
Number of operations (self-reported) 2.0 3.0 7.7 -1.4 2.1 -0.9 -0.6 2.5 1.3 2.4 0.2 -0.5 -1.9 2.8 1.3 2.1
Average weekly beer plus cider intake 0.6 0.8 4.3 -0.8 -0.1 -0.6 -2.1 -0.1 -0.4 -0.3 1.3 -1.3 0.8 -0.1 -1.2 -0.6
Irritability 1.2 2.0 3.6 -1.4 -1.5 1.9 0.9 -1.8 -1.8 -1.8 -0.2 -0.2 -0.6 -1.9 -1.5 -0.8
Risk taking 0.4 0.6 1.2 0.3 -0.7 0.3 -0.6 -1.0 -0.9 -1.1 -0.2 1.0 0.6 -1.1 -0.6 -1.1
Ever had prostate specific antigen (PSA) test 0.8 0.9 4.6 -2.1 -0.2 0.6 1.2 -0.3 -0.2 -0.5 -0.4 -0.1 -1.3 -0.5 0.9 1.2
Fractured/broken bones in last 5 years 0.3 0.4 1.2 0.9 -0.5 0.0 0.4 -0.2 0.8 -0.2 -1.1 -0.2 -0.1 -0.1 1.1 -0.7
Age started oral contraceptive pill 0.5 0.6 2.0 0.6 -0.1 1.4 0.9 0.8 0.2 -0.1 -0.2 -0.6 0.5 0.8 0.9 1.3
Diastolic blood pressure, automated reading 0.5 1.5 5.6 0.3 -1.9 0.3 -0.2 -1.7 -0.3 -2.4 -1.7 -0.0 0.6 -1.8 0.6 -0.2
Ever depressed for a whole week 1.2 1.5 5.9 -2.4 -1.2 1.0 -0.5 -1.1 -1.1 -1.5 -1.4 -0.3 -1.3 -1.1 -0.4 1.1
Unable to work because of sickness or disability 0.9 1.2 5.0 -1.9 0.1 0.2 0.9 -1.4 -0.6 -0.8 0.3 -0.8 -2.2 -1.4 -0.6 0.4
Commuting to job workplace: Cycle 0.6 0.8 2.7 0.6 -0.3 -0.6 -0.3 -0.4 -1.2 -0.1 0.6 1.6 0.6 -0.3 -1.7 -1.0
Myopia 0.5 0.8 2.4 -1.5 0.1 -1.0 -1.4 0.1 -0.1 0.2 0.4 0.3 -1.5 0.2 0.1 1.6
Vascular/heart problems diagnosed by doctor 0.2 0.4 2.0 0.4 0.9 -0.6 0.1 0.6 0.4 0.7 0.3 1.4 0.5 0.6 -0.6 -0.1
Cholesterol lowering medication 0.9 1.3 4.8 0.6 -2.2 0.4 0.5 -1.3 -1.6 -1.6 -0.8 -0.6 0.7 -1.4 -0.7 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 5.0 0.1 -0.2 -0.8 -0.9 -0.2 -0.1 0.1 -0.9 -2.2 -0.4 -0.4 -0.9 -0.6
Pain experienced in last month 0.3 0.6 2.5 0.5 -0.4 0.2 -0.6 1.6 -0.6 0.5 -0.4 0.5 0.2 1.6 0.3 0.5
Supplements: Calcium 0.5 0.5 1.4 0.7 1.1 1.2 0.3 -0.1 1.0 0.7 -0.6 -0.1 0.8 -0.1 1.0 -0.6
Basal cell carcinoma (self-reported) 0.2 0.3 1.1 -0.4 0.3 0.0 0.4 0.3 0.4 0.3 -0.6 -0.7 -1.1 0.2 0.5 0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.3 0.6 0.6 -0.3 0.2 0.9 -0.5 1.5 0.2 0.3 0.8 1.2 -1.2 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 4.0 1.4 1.9 -0.7 0.5 1.8 0.4 2.0 1.6 -1.2 0.4 1.9 -0.8 0.2
Heart disease (siblings) 0.9 1.1 2.2 0.6 -1.0 0.6 0.5 -1.2 -0.9 -1.0 -1.2 -1.2 1.5 -1.3 -1.0 -1.3
Alcohol drinker status: Previous 2.6 3.0 7.9 -1.1 -1.9 0.7 1.0 -2.7 -2.0 -2.5 -1.7 -1.1 0.0 -2.8 -1.2 -1.0
Pack years of smoking 1.0 1.4 3.6 -1.2 -0.5 1.4 1.1 -1.1 -0.7 -0.2 1.0 -1.7 -1.9 -1.3 -1.5 0.6
Impedance of whole body 0.3 1.3 4.6 -1.4 1.8 -0.5 0.1 0.8 1.0 2.1 0.6 0.4 -1.7 1.0 -0.9 -0.4
Leg fat mass (left) 0.2 0.9 3.1 -0.4 -1.5 0.3 0.5 -0.9 -0.9 -1.3 -1.8 -0.8 0.7 -0.9 -0.2 -0.3
Arm predicted mass (left) 0.2 1.2 7.3 2.1 -0.4 0.1 0.7 0.2 -0.2 -0.8 -1.4 0.3 2.7 0.0 0.7 -0.6