TWAS hub - TRIP12

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.2270	0.0860	6.6e-03	0.002	NA	-0.006	NA	0.037	2.7e-01	NA	9.3e-01	NA	9.2e-03
2	YFS	Blood	0.0629	0.0154	5.2e-11	0.035	0.034	0.053	0.047	0.050	1.1e-11	2e-11	9.2e-17	3.6e-15	4.2e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of siblings: Diabetes	6.0	7.4	10.7	-3.3	-2.0
Leg fat percentage (right)	5.6	20.3	32.9	-2.8	-5.7
Arm fat percentage (left)	5.2	20.7	32.9	-2.9	-5.7
Body fat percentage	5.1	20.2	33.2	-2.7	-5.8
Leg fat percentage (left)	5.1	18.3	28.1	-2.9	-5.3
Had menopause	4.7	5.9	8.0	-1.9	-2.8
Arm fat percentage (right)	4.7	18.4	30.5	-2.5	-5.5
Leg fat mass (right)	4.7	18.3	30.8	-2.4	-5.5
Trunk fat percentage	4.5	18.1	28.9	-2.7	-5.4
Arm fat mass (left)	4.4	17.9	28.9	-2.6	-5.4
Leg fat mass (left)	4.4	17.2	28.4	-2.5	-5.3
Waist circumference	4.3	15.9	25.7	-2.5	-5.1
Arm fat mass (right)	4.3	17.5	29.5	-2.4	-5.4
Whole body fat mass	4.3	18.1	30.1	-2.5	-5.5
Body mass index (BMI)	4.1	17.5	30.0	-2.2	-5.5
Illnesses of father: Heart disease	4.1	5.7	11.1	0.6	-3.3
Alzheimer’s Disease (including proxy)	4.0	5.9	8.5	1.8	2.9
Diabetes (father)	4.0	5.0	7.7	-1.5	-2.8
Trunk fat mass	4.0	17.0	26.8	-2.7	-5.2
BMI	3.9	22.4	42.0	-1.7	-6.5
Systolic blood pressure, automated reading	3.7	10.7	13.9	-2.7	-3.7
Friendships satisfaction	3.5	4.3	6.3	1.5	2.5
Alcohol drinker status: Previous	3.3	3.8	4.5	1.7	2.1
Number of children fathered	3.2	3.6	5.2	-1.4	-2.3
Emphysema/chronic bronchitis	3.1	3.4	6.9	-2.6	-0.2
Qualifications: A levels/AS levels or equivalent	2.9	6.4	10.0	1.7	3.2
Commuting to job workplace: Walk	2.7	2.9	4.4	-1.2	-2.1
Noisy workplace	2.6	3.2	6.0	-0.6	-2.5
Diastolic blood pressure, automated reading	2.6	8.0	13.7	-1.5	-3.7
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	5.8	-0.7	-2.4
Schizophrenia vs Biploar Disorder	2.5	3.3	6.1	-0.8	2.5
Relative age voice broke	2.5	3.8	6.6	1.0	2.6
Age when periods started (menarche)	2.5	6.0	10.7	1.1	3.3
Serious illness, injury or assault to yourself	2.5	3.0	6.0	0.2	-2.4
Alcohol usually taken with meals	2.4	3.8	7.6	-0.1	2.8
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	4.7	0.9	2.2
Leg pain on walking	2.4	3.0	3.8	-1.5	-2.0
Hand grip strength (right)	2.3	6.3	10.8	1.3	3.3
Medication: Atenolol	2.2	2.8	4.0	-2.0	-1.3
Forced vital capacity (FVC)	2.2	8.3	11.8	2.2	3.4
Forced vital capacity (FVC), Best measure	2.2	8.1	13.5	1.7	3.7
Medication: Bendroflumethiazide	2.2	3.4	4.1	-2.0	-1.6
Weight	2.1	10.6	16.9	-2.1	-4.1
Medication: Blood pressure	2.1	3.9	4.6	-1.8	-2.2
Lung FVC	2.0	10.4	18.7	1.4	4.3
Medication: Co-codamol	2.0	2.3	3.7	-1.0	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.5	9.7	1.8	3.1
Wheeze or whistling in the chest in last year	2.0	3.6	6.7	-2.6	-0.8
Chest pain or discomfort	2.0	2.9	4.6	-1.1	-2.1
Pain type(s) experienced in last month: Hip pain	2.0	2.6	4.9	-0.5	-2.2
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.5	-0.4	-2.1
Had other major operations	1.9	2.4	3.9	-0.9	-2.0
Hip circumference	1.9	8.4	11.2	-2.4	-3.4
Prospective memory result	1.9	2.4	4.4	-2.1	-0.6
Relative age of first facial hair	1.8	3.8	7.2	-0.6	2.7
Supplements: Zinc	1.8	2.0	2.3	1.3	1.5
Stomach or abdominal pain in last month	1.8	2.2	3.9	0.7	-2.0
Number of incorrect matches in round	1.8	2.9	4.5	-1.2	2.1
Forced expiratory volume in 1-second (FEV1)	1.8	5.9	8.4	1.9	2.9
Family relationship satisfaction	1.8	2.2	4.0	-0.6	2.0
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.4	-0.3	2.1
Cholesterol lowering medication	1.8	2.7	4.0	-1.2	-2.0
Worry (Nagel 2018)	1.7	3.6	5.3	-2.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	3.3	-1.4	-1.8
Long-standing illness, disability or infirmity	1.7	2.6	5.2	-0.2	-2.3
Medication for cholesterol	1.7	2.5	4.0	1.0	2.0
Irritability	1.7	2.9	5.3	-0.7	2.3
Age started oral contraceptive pill	1.7	2.1	2.9	-1.2	-1.7
Pack years of smoking	1.7	2.4	4.7	-2.2	-0.4
Triglycerides	1.6	2.6	3.2	-1.8	-1.4
Medication: Omeprazole	1.6	1.9	3.6	-0.4	-1.9
Suffer from ‘nerves’	1.6	2.4	2.6	-1.6	1.5
Alzheimer’s Disease (in mother)	1.5	1.8	1.9	1.3	1.4
Mean Putamen Volume	1.5	1.7	2.0	1.4	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.4	-1.9	-1.2
Gout (self-reported)	1.5	2.0	3.9	2.0	0.4
Worry too long after embarrassment	1.5	2.6	4.7	0.7	2.2
Medication for pain relief, constipation, heartburn	1.5	2.6	3.2	1.8	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	3.4	1.8	1.7
Ever had prostate specific antigen (PSA) test	1.5	1.7	2.3	-1.5	-1.1
Sensitivity / hurt feelings	1.4	2.5	3.6	1.2	1.9
Pack years adult smoking proportion	1.4	2.1	3.8	-1.9	-0.6
Medication: Ramipril	1.4	1.8	3.5	-0.3	-1.9
Tense / ‘highly strung’	1.4	2.3	3.7	-1.9	0.9
Pulse wave peak to peak time	1.4	1.6	1.7	1.3	1.3
Commuting to job workplace: Cycle	1.4	1.7	3.0	-0.6	-1.7
Crohns Disease (2017)	1.3	2.8	5.5	2.3	0.3
Age at First Birth	1.3	1.9	3.8	-1.9	-0.2
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	0.5	-1.7
Illnesses of siblings	1.3	1.8	2.6	1.1	1.6
Mouth/teeth dental problems: Loose teeth	1.3	1.5	1.9	1.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.7	-1.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.0	0.4	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	1.9	1.1	1.4
Illnesses of father: None of the above (group 1)	1.3	1.7	2.6	-0.8	1.6
Fractured/broken bones in last 5 years	1.3	1.7	3.1	1.8	-0.6
Pulse wave Arterial Stiffness index	1.2	1.4	1.5	-1.2	-1.1
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	2.8	1.1	1.7
Migraine (self-reported)	1.2	1.4	2.8	-0.3	1.7
Overall health rating	1.2	2.5	2.6	-1.6	-1.6
Medication: Aspirin	1.2	1.5	3.0	-0.1	-1.7
Ulcerative Colitis	1.1	1.5	2.2	-1.5	0.9
Smoking Status	1.1	2.7	5.1	2.3	-0.5
Hand grip strength (left)	1.1	3.0	3.2	1.7	1.8
Number of treatments/medications taken	1.1	2.0	2.8	-1.1	-1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.4	-1.5	0.3
Fluid intelligence score	1.1	2.3	2.9	1.7	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.5	-0.4	-1.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.7	-1.0	-1.3
Loneliness, isolation	1.1	1.5	2.8	-1.7	-0.5
Wears glasses or contact lenses	1.1	1.3	2.4	0.4	-1.5
Heart disease (siblings)	1.1	1.3	2.6	-1.6	0.1
Systolic Blood Pressure	1.0	5.1	7.0	-1.8	-2.6
Hearing difficulty/problems: Yes	1.0	1.6	3.2	-0.1	-1.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.6	-0.1	-1.6
Nervous feelings	1.0	1.9	2.2	-1.3	1.5
High blood pressure (siblings)	1.0	1.4	2.8	0.1	-1.7
Medication: Aspirin	1.0	1.3	2.4	-0.4	-1.6
Mother’s age at death	1.0	1.3	1.9	1.4	0.8
Alzheimer’s Disease (in father)	0.9	1.0	2.0	0.0	1.4
Schizophrenia (2014)	0.9	2.0	3.0	-1.0	1.7
Allergy or Eczema	0.9	2.3	4.4	0.5	2.1
Neuroticism	0.9	2.1	3.2	-1.8	1.0
Supplements: Glucosamine	0.9	1.1	1.9	-1.4	0.6
Mouth/teeth dental problems	0.9	1.4	1.5	-1.2	1.1
Medication: Simvastatin	0.9	1.3	1.9	-0.9	-1.4
Time employed in main current job	0.9	1.0	1.9	-0.3	-1.4
Hair/balding pattern: Pattern 3	0.9	1.3	1.6	-1.0	1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.9	1.4	-0.7
Schizophrenia (2018)	0.8	1.8	2.2	-1.5	1.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	2.0	1.3	1.4
Prostate Cancer	0.8	1.1	2.1	0.3	-1.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.1	-1.4	-0.4
Neuroticism score	0.8	1.6	1.8	-1.4	1.2
Worrier / anxious feelings	0.8	1.6	2.3	-1.5	0.9
Exposure to tobacco smoke at home	0.8	0.9	0.9	-0.9	-1.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.2	1.5	0.7
Health satisfaction	0.8	1.1	1.6	-0.7	-1.3
Shortness of breath walking on level ground	0.8	0.9	1.8	0.1	-1.4
Qualifications: College or University degree	0.8	2.6	3.3	1.4	1.8
Mean time to correctly identify matches	0.8	1.5	2.7	-1.6	0.6
Alcohol intake frequency.	0.8	1.9	3.2	-0.8	1.8
Guilty feelings	0.8	1.1	2.1	-1.5	-0.4
Crohns Disease (2012)	0.7	1.2	1.5	1.2	1.0
Neuroticism (2016)	0.7	1.0	1.3	-0.8	1.1
Blood Red Count	0.7	7.0	12.0	-1.5	-3.5
Vitamin and mineral supplements	0.7	0.9	1.5	1.2	-0.6
Diabetes (mother)	0.7	0.9	1.1	-0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.1	1.0	1.5
Qualifications: None of the above	0.7	1.5	2.4	-0.7	-1.6
Financial difficulties in last 2 years	0.7	1.0	1.0	1.0	-1.0
Headache pain in last month	0.7	1.3	2.6	0.1	1.6
Glaucoma (self-reported)	0.7	0.9	1.6	0.3	-1.3
Comparative body size at age 10	0.7	1.8	3.5	-0.3	-1.9
Neck or shoulder pain in last month	0.7	1.0	1.9	0.4	-1.4
Medication: Allopurinol	0.7	0.9	1.3	1.1	0.7
Osteoporosis (self-reported)	0.7	0.9	1.6	0.5	-1.3
Number of self-reported non-cancer illnesses	0.7	1.3	2.1	-1.5	-0.7
Illnesses of father: High blood pressure	0.7	0.9	1.4	0.7	-1.2
Severe depression (siblings)	0.6	0.7	1.2	0.4	-1.1
Leg fat-free mass (left)	0.6	3.0	5.2	-0.9	-2.3
Taking other prescription medications	0.6	1.0	1.6	-0.6	-1.3
High blood pressure (mother)	0.6	0.8	1.4	-0.5	-1.2
Impedance of leg (left)	0.6	2.8	4.5	1.0	2.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	0.2	1.3
Pulse rate	0.6	1.0	1.9	-1.4	0.1
Breastfed as a baby	0.6	0.8	1.4	-0.3	1.2
Hypertension (Self-reported)	0.6	1.6	2.6	-0.7	-1.6
Average weekly red wine intake	0.6	0.9	1.8	1.4	-0.1
Qualifications: nursing, teaching	0.6	1.0	2.0	-0.2	1.4
Mineral and other dietary supplements	0.6	0.8	1.6	0.3	-1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.2	-1.1	0.6
Ever taken oral contraceptive pill	0.6	0.7	1.1	-0.5	-1.1
Financial situation satisfaction	0.6	0.8	0.8	-0.9	-0.8
Impedance of whole body	0.6	3.3	6.5	0.3	2.5
Bipolar Disorder or Schizophrenia	0.5	1.3	2.0	-0.8	1.4
Depression (Nagel 2018)	0.5	0.7	1.0	-1.0	-0.7
Major Depression (MDD)	0.5	0.6	0.7	0.8	-0.7
Reaction Time	0.5	0.9	1.3	-0.8	1.1
Bipolar Disorder (2011)	0.5	0.5	0.7	0.8	-0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	0.1	-1.2
Fasting Glucose	0.5	0.6	1.0	-0.5	-1.0
HbA1C	0.5	0.6	1.1	1.1	-0.1
HDL Cholesterol	0.5	0.9	1.6	-0.3	-1.3
Lupus	0.5	0.8	1.5	1.2	-0.0
Chronotype (morning person)	0.5	1.2	2.1	-0.5	-1.4
High blood pressure	0.5	1.5	2.8	-0.3	-1.7
Leg predicted mass (left)	0.5	2.9	5.1	-0.8	-2.2
Allergy	0.5	1.2	1.6	1.2	-0.9
Impedance of arm (right)	0.5	2.4	4.7	0.5	2.2
Happiness	0.5	0.6	0.9	1.0	0.5
Lung cancer (father)	0.5	0.6	1.1	-1.0	0.2
Hair/balding pattern: Pattern 4	0.5	1.3	2.0	1.4	-0.8
Eye problems/disorders: None of the above	0.5	0.6	0.9	-0.4	1.0
Medication: Blood pressure	0.5	0.9	1.0	-1.0	-0.9
Medication: Seretide 50 evohaler	0.5	0.5	1.0	-1.0	-0.3
Heart disease (mother)	0.5	0.6	1.1	-0.2	-1.1
Age at last live birth	0.5	0.8	1.3	0.4	1.2
Ever had bowel cancer screening	0.5	0.6	0.9	-0.5	-1.0
Medication: Gliclazide	0.5	0.5	0.8	0.5	-0.9
Smoking status: Current	0.5	0.8	1.2	0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.4	-0.1	1.2
Medication: Paracetamol	0.5	0.8	1.4	1.2	-0.4
Basal metabolic rate	0.5	2.5	4.5	-0.7	-2.1
Unable to work because of sickness or disability	0.5	0.7	1.3	-1.1	0.1
Bipolar Disorder (2018)	0.4	0.6	0.7	0.6	0.9
Neuroticism (Nagel 2018)	0.4	0.9	1.3	-1.1	0.8
Irritable Bowel Disease (IBD)	0.4	1.0	1.3	1.2	0.8
Ovarian Cancer	0.4	0.5	1.0	0.3	1.0
Waist Hip Ratio (WHR)	0.4	1.9	3.4	-0.6	-1.9
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	-0.1	0.9
Impedance of leg (right)	0.4	1.7	2.2	1.1	1.5
Current tobacco smoking	0.4	0.7	1.0	0.7	-1.0
Maternal smoking around birth	0.4	0.6	0.9	0.5	0.9
Fed-up feelings	0.4	0.7	1.0	1.0	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	-1.0	-0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.1	-0.7	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.6	0.8	-0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.1	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.3	-1.1	-0.3
Father’s age at death	0.4	0.6	1.2	0.2	1.1
Medication: Cholesterol lowering	0.4	0.6	1.2	-1.1	-0.2
Impedance of arm (left)	0.4	2.0	4.0	0.1	2.0
Peak expiratory flow (PEF)	0.4	1.0	1.8	1.3	0.5
Medication: Amlodipine	0.4	0.5	1.1	-0.1	-1.0
Number of full brothers	0.4	0.5	1.0	1.0	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.5	-0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.9	0.5	1.0
Back pain experienced in last month	0.4	0.6	1.0	-1.0	-0.3
Breast cancer (self-reported)	0.4	0.5	1.0	-1.0	-0.1
Osteoarthritis (self-reported)	0.4	0.6	1.1	-0.2	-1.1
High cholesterol (Self-reported)	0.4	0.7	0.8	-0.9	-0.8
Arm fat-free mass (left)	0.4	2.2	4.4	-0.2	-2.1
Number of operations (self-reported)	0.4	0.6	1.0	-0.4	-1.0
Myopia	0.4	0.6	1.1	0.4	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.6	0.7	1.2
Arm predicted mass (left)	0.4	2.0	3.9	-0.2	-2.0
Ulcerative Colitis (UC)	0.3	0.5	0.8	-0.4	0.9
Breast Cancer	0.3	0.7	1.0	-0.5	-1.0
Height	0.3	5.0	9.9	-0.2	3.1
Lung FEV1/FVC ratio	0.3	1.5	2.5	-0.7	-1.6
Average weekly spirits intake	0.3	0.3	0.6	0.8	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.3	-0.5	0.5
Angina	0.3	0.4	0.9	0.9	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.3	0.8
Illnesses of mother	0.3	0.3	0.4	0.6	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.8	0.5
Blood clot in the leg (DVT)	0.3	0.3	0.6	0.8	0.3
Arm fat-free mass (right)	0.3	1.6	3.2	-0.3	-1.8
Age at first live birth	0.3	0.5	0.6	-0.6	-0.8
Angina (self-reported)	0.3	0.4	0.8	0.9	0.1
Arm predicted mass (right)	0.3	1.4	2.5	-0.5	-1.6
Pulse rate, automated reading	0.3	1.1	1.9	-0.5	-1.4
Number of full sisters	0.3	0.4	0.7	-0.4	0.8
Had major operations	0.3	0.3	0.6	-0.2	0.8
Knee pain experienced in last month	0.3	0.4	0.6	-0.5	-0.8
Leg fat-free mass (right)	0.3	1.7	2.7	-0.9	-1.6
Eye problems/disorders: Cataract	0.3	0.3	0.5	0.7	-0.4
Leg predicted mass (right)	0.3	1.7	2.6	-0.8	-1.6
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.2	-0.8
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.8	0.3
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.9	0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.7	-0.1
LDL Cholesterol	0.2	0.3	0.5	-0.7	-0.1
Heel T-Score	0.2	1.7	2.4	-1.5	1.0
Cardiovascular Disease	0.2	0.5	1.1	0.0	-1.0
Medication: Metformin	0.2	0.2	0.4	-0.0	-0.7
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.5	0.6	0.7
Multivitamins +/- minerals	0.2	0.3	0.4	-0.6	0.4
Pain all over the body in last month	0.2	0.2	0.4	-0.1	-0.7
Diabetes (self-reported)	0.2	0.3	0.5	-0.7	0.2
Number of live births	0.2	0.3	0.6	0.3	0.8
Medication: Lansoprazole	0.2	0.2	0.4	-0.1	-0.6
Standing height	0.2	2.3	4.6	0.2	2.1
Length of working week for main job	0.2	0.2	0.5	-0.7	-0.0
Loud music exposure frequency	0.2	0.3	0.5	0.7	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.3	-0.5	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.3	0.6
Whole body fat-free mass	0.2	1.2	2.1	-0.5	-1.5
Diabetes diagnosed by doctor	0.2	0.3	0.4	-0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.6	0.3
Whole body water mass	0.2	1.1	2.1	-0.3	-1.4
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	-0.1
Ever smoked	0.2	0.3	0.5	0.7	-0.1
Pain experienced in last month	0.2	0.3	0.6	0.0	0.8
Supplements: Calcium	0.2	0.3	0.4	-0.3	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	0.7	0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	0.0	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	0.4	0.6
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.6	-0.2
Rheumatoid Arthritis	0.1	0.1	0.2	-0.3	-0.4
Blood Eosinophil Count	0.1	1.0	1.8	1.4	0.3
Blood White Count	0.1	0.4	0.8	0.9	-0.2
Respiratory disease	0.1	0.2	0.5	-0.7	0.1
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.1	-0.3	-0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.1	-0.4
Medication: Levothyroxine sodium	0.1	0.2	0.2	0.5	0.4
Sitting height	0.1	1.0	1.4	0.8	1.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.2	-0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	0.4
Trunk fat-free mass	0.1	0.3	0.6	-0.2	-0.8
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.6	0.1
Falls in the last year	0.1	0.1	0.1	-0.4	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.4	0.0
Asthma	0.1	0.3	0.4	-0.4	0.6
Depression (self-reported)	0.1	0.1	0.3	0.5	-0.1
Trunk predicted mass	0.1	0.3	0.5	-0.2	-0.7
Pulse wave reflection index	0.1	0.1	0.2	0.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.6	-0.2
Comparative height size at age 10	0.1	0.7	1.3	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	-0.3	0.6
Mood swings	0.1	0.1	0.2	0.4	0.3
Asthma (self-reported)	0.1	0.2	0.4	-0.7	0.1
Miserableness	0.1	0.2	0.3	0.3	-0.6
Medication: Lisinopril	0.1	0.1	0.3	-0.5	-0.0
Medication: Atorvastatin	0.1	0.2	0.3	-0.1	0.6
Risk taking	0.1	0.2	0.3	0.5	-0.3
Ever depressed for a whole week	0.1	0.1	0.2	-0.1	0.4
Blood Platelet Count	0.0	0.4	0.6	0.4	-0.8
Hypothyroidism (self reported)	0.0	0.0	0.0	0.1	0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.2	-0.2
Hair Pigment	0.0	0.6	1.2	-0.1	-1.1
Tanning	0.0	0.6	0.8	0.6	0.9
Past tobacco smoking	0.0	0.1	0.2	-0.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.0	0.0
Heart attack	0.0	0.0	0.1	0.3	0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.2	-0.2
Birth weight of first child	0.0	0.1	0.1	0.3	-0.3
Medication: Paracetamol	0.0	0.0	0.0	-0.2	0.2
Birth weight	0.0	0.0	0.1	0.0	0.3
Exposure to tobacco smoke outside home	0.0	0.0	0.0	-0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.2	0.1
Medication: Ibuprofen	0.0	0.0	0.1	0.0	-0.3
Supplements: Vitamin C	0.0	0.1	0.1	-0.3	0.0
Smoking status: Previous	0.0	0.0	0.1	0.3	0.1
Hearing aid user	0.0	0.0	0.1	-0.2	0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.2	0.1
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	0.1

Hub : Genes

TRIP12

Models

Trait associations