Hub : Genes

TRMT10A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.2550	0.0590	1.5e-06	0.167	NA	0.150	NA	0.186	7.1e-12	NA	8.7e-11	NA	3.4e-13
2	GTEx	Testis	0.3540	0.0750	6.6e-06	0.259	NA	0.259	NA	0.263	6.8e-12	NA	6.9e-12	NA	4.8e-12
3	METSIM	Adipose	0.0542	0.0235	5.8e-03	-0.002	0.006	0.007	0.008	0.006	8.1e-01	0.036	2.8e-02	0.021	3.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.0	0.1	0.3	0.2	0.1
Bipolar Disorder or Schizophrenia	0.4	0.9	1.7	1.3	0.9	0.5
Depressed Affect (Nagel 2018)	3.4	7.2	10.1	-3.2	-3.0	-1.6
Depression (Nagel 2018)	2.6	4.0	6.8	-2.6	-2.3	-0.2
Intelligence (Savage-Jansen 2018)	1.6	5.0	7.2	1.3	2.7	2.5
Neuroticism (Nagel 2018)	3.9	9.2	13.5	-3.7	-3.1	-2.1
Schizophrenia (2018)	0.6	1.2	2.0	1.4	1.1	0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	0.6	-0.2
Worry (Nagel 2018)	3.1	6.6	7.2	-2.6	-2.7	-2.4
Alzheimer’s Disease (in mother)	1.1	1.3	1.9	-1.3	-1.4	-0.5
Alzheimer’s Disease (in father)	0.7	0.8	2.1	0.0	0.6	1.4
Alzheimer’s Disease (including proxy)	0.9	1.3	2.3	-1.5	-0.8	1.0
Crohns Disease (2017)	0.5	1.1	1.8	0.8	-0.9	-1.4
Irritable Bowel Disease (IBD)	0.6	1.5	2.2	0.8	-1.3	-1.5
Ulcerative Colitis (UC)	0.7	1.2	1.7	0.9	-1.1	-1.3
Major Depression (MDD)	4.2	5.1	7.4	-2.7	-2.5	-1.2
Reaction Time	0.1	0.2	0.5	-0.0	-0.7	-0.0
Verbal and Numeric Reasoning (VNR)	1.7	4.2	6.3	1.5	2.5	2.0
Breast Cancer	0.2	0.5	1.1	-1.1	-0.2	-0.5
Ovarian Cancer	0.5	0.6	1.5	-0.3	0.6	1.2
Prostate Cancer	1.2	1.6	2.8	-1.4	-1.7	-0.5
Age at First Birth	3.7	5.4	7.3	2.0	2.2	2.7
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	0.0	0.4
Body Mass Index (BMI) (2010)	0.7	0.9	2.3	-0.3	-1.5	-0.6
Coronary Artery Disease (CAD)	0.4	0.5	0.6	0.8	0.7	0.7
Crohns Disease (2012)	0.8	1.3	3.0	1.7	0.8	0.5
Mean Putamen Volume	0.3	0.3	0.5	-0.7	0.3	-0.5
Fasting Glucose	0.3	0.3	0.7	0.4	0.9	0.4
HbA1C	0.8	0.9	2.1	0.7	1.5	-0.0
HDL Cholesterol	0.8	1.4	2.1	0.9	1.4	1.1
LDL Cholesterol	1.2	2.0	3.6	1.9	0.4	-1.5
Lupus	2.5	3.8	9.0	-1.2	-1.0	-3.0
Neuroticism (2016)	2.8	4.1	5.5	-2.4	-2.1	-1.5
Primary Biliary Cirrhosis	0.4	0.5	1.2	1.1	0.6	-0.1
Rheumatoid Arthritis	0.7	0.9	1.3	1.2	1.0	0.7
Schizophrenia (2014)	0.2	0.4	0.6	0.7	0.7	0.4
Triglycerides	2.0	3.3	7.0	-0.9	-1.5	-2.6
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.6	-0.5	-1.6	-1.2
Ulcerative Colitis	0.1	0.1	0.3	0.6	-0.3	-0.0
Blood Eosinophil Count	0.2	1.8	3.1	-1.8	-1.0	1.0
Blood Platelet Count	0.6	7.1	18.8	-1.6	0.1	4.3
Blood Red Count	0.4	3.4	5.8	-2.4	-2.1	0.5
Blood White Count	0.1	1.1	1.8	-1.0	-0.6	1.3
Heel T-Score	0.4	3.6	7.5	-2.7	-1.7	-0.6
BMI	0.7	3.9	8.4	-1.8	-2.9	-0.4
Height	1.8	34.7	51.7	3.4	7.2	6.4
Waist Hip Ratio (WHR)	1.5	6.9	14.3	-2.5	-3.8	-0.1
Systolic Blood Pressure	0.6	3.1	4.8	2.2	1.9	-1.0
Smoking Status	2.2	5.3	7.9	-1.3	-2.8	-2.6
Allergy or Eczema	0.6	1.6	3.4	-0.0	1.2	1.9
Cardiovascular Disease	0.1	0.4	0.6	0.8	-0.8	-0.1
Hypothyroidism (self reported)	0.3	0.8	1.1	-1.0	-0.6	-1.0
Respiratory disease	0.0	0.1	0.2	-0.2	-0.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.5	1.6	-0.1	0.2
Lung FEV1/FVC ratio	0.2	1.2	1.5	1.2	0.9	1.1
Lung FVC	0.6	3.2	8.5	-2.9	-0.9	-0.4
Neuroticism	2.8	6.7	8.2	-2.9	-2.7	-2.2
Chronotype (morning person)	0.1	0.2	0.7	-0.2	0.8	0.3
Hair Pigment	0.0	0.3	0.6	0.8	0.4	-0.0
Tanning	0.1	0.8	1.3	1.0	1.2	0.4
Hand grip strength (left)	0.6	1.6	3.8	0.4	1.9	0.8
Number of treatments/medications taken	0.1	0.1	0.2	0.5	-0.1	0.4
Average weekly spirits intake	1.4	1.7	3.0	-1.7	-1.2	0.8
Sensitivity / hurt feelings	0.7	1.2	2.6	-0.7	-0.8	-1.6
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.4	-1.9	-2.1	-0.1
Hearing difficulty/problems: Yes	0.3	0.4	1.3	1.1	0.2	-0.0
Relative age of first facial hair	0.8	1.6	3.5	-1.9	-0.6	0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.4	-0.1	-0.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.2	-0.4	-1.2	-2.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.1	-1.1	-1.0	0.4
Systolic blood pressure, automated reading	0.6	1.7	2.7	1.6	1.6	0.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	0.4	-0.4	-0.5
Angina	0.5	0.7	1.5	1.2	0.4	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.4	-0.2	-0.9
Vitamin and mineral supplements	1.0	1.3	2.4	-0.8	-0.9	-1.6
Supplements: Zinc	0.3	0.4	0.8	0.5	0.0	-0.9
Medication: Co-codamol	0.8	0.9	1.6	0.1	1.1	1.3
Medication: Metformin	1.1	1.5	4.2	2.0	0.4	-0.6
Diabetes (father)	0.2	0.2	0.3	-0.1	-0.5	-0.5
Diabetes (mother)	0.1	0.1	0.2	0.3	-0.5	0.0
Severe depression (siblings)	0.7	0.8	2.0	-0.3	-0.4	-1.4
Pack years adult smoking proportion	0.5	0.7	1.0	-1.0	-0.7	0.8
Impedance of leg (right)	1.8	8.6	11.8	3.4	3.4	1.6
Leg fat-free mass (left)	0.2	1.2	3.0	-0.8	0.1	1.7
Trunk fat percentage	0.1	0.4	1.0	0.0	-0.4	1.0
Hand grip strength (right)	0.4	1.2	1.9	-0.3	1.4	1.3
Townsend deprivation index at recruitment	2.3	3.2	5.0	-1.6	-2.2	-1.5
Current tobacco smoking	2.9	4.7	8.3	-1.2	-2.1	-2.9
Average weekly fortified wine intake	0.7	0.8	1.4	-0.6	-1.2	-0.8
Maternal smoking around birth	1.7	2.4	6.2	0.1	-1.0	-2.5
Fed-up feelings	2.4	4.3	6.5	-2.5	-2.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.7	7.1	-2.5	-2.7	-0.9
Relative age voice broke	0.3	0.5	0.7	-0.8	-0.7	0.5
Taking other prescription medications	0.5	0.7	1.9	-0.3	-0.5	1.4
Age when periods started (menarche)	0.2	0.5	0.9	0.9	0.6	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.4	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.6	1.6	0.5	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	-0.6	-0.7	-0.7
Qualifications: CSEs or equivalent	0.6	0.7	1.4	-0.6	-1.2	-0.7
Serious illness, injury or assault to yourself	0.3	0.4	1.0	0.5	-0.1	1.0
High blood pressure	0.0	0.0	0.0	0.2	-0.2	0.1
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.2	-0.0	1.0	1.5
Multivitamins +/- minerals	0.7	0.9	2.0	-0.6	0.6	1.4
Stomach or abdominal pain in last month	1.5	1.9	3.0	-1.7	-1.6	0.1
Supplements: Glucosamine	1.2	1.6	3.7	0.4	1.0	1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.9	-0.1	0.6
Medication: Atenolol	0.6	0.8	1.9	1.4	-0.4	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.4	-0.7	-0.5
Sitting height	3.9	27.7	39.3	2.8	6.3	6.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.4	0.1	0.0
High blood pressure (mother)	0.1	0.1	0.3	0.1	0.6	-0.0
Body mass index (BMI)	1.1	4.8	10.1	-1.9	-3.2	-0.8
Impedance of leg (left)	2.1	10.1	14.6	3.5	3.8	1.9
Leg predicted mass (left)	0.2	1.3	3.2	-0.8	-0.0	1.8
Trunk fat mass	0.2	0.8	2.1	-0.2	-0.4	1.5
Waist circumference	0.8	3.1	7.1	-1.5	-2.7	-0.1
Number of incorrect matches in round	0.2	0.3	0.5	-0.5	0.4	0.7
Past tobacco smoking	1.1	2.1	2.9	1.4	1.7	1.2
Alcohol usually taken with meals	0.1	0.2	0.3	0.3	0.5	-0.5
Nervous feelings	4.3	8.0	8.9	-2.6	-3.0	-2.9
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	5.6	-2.2	-2.4	-0.4
Hearing difficulty/problems with background noise	0.3	0.6	1.3	0.6	-0.2	-1.1
Hair/balding pattern: Pattern 2	0.6	0.8	1.1	1.0	0.6	1.1
Had menopause	0.3	0.3	0.4	-0.5	-0.5	-0.7
Had other major operations	0.1	0.1	0.2	0.5	0.2	-0.2
Forced vital capacity (FVC)	1.6	6.0	9.7	-0.2	2.9	3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	1.0	0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	9.6	-3.1	-1.6	-0.2
Qualifications: None of the above	0.5	1.0	2.1	-0.3	-1.4	-0.9
Financial difficulties in last 2 years	0.1	0.1	0.2	0.4	0.1	-0.4
Mouth/teeth dental problems	0.2	0.4	0.5	0.6	0.7	0.5
Heart attack	0.3	0.4	0.9	-0.5	-0.9	-0.3
Allergy	0.0	0.1	0.1	0.3	-0.0	-0.4
Pain all over the body in last month	0.2	0.2	0.4	0.6	0.3	0.4
Diabetes (self-reported)	0.4	0.6	1.5	1.2	-0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.7	1.0	1.3	0.6
Medication: Ramipril	0.2	0.3	0.7	0.1	0.2	0.8
Medication: Simvastatin	0.9	1.4	3.8	1.9	0.3	-0.5
Fluid intelligence score	0.7	1.5	2.7	0.9	1.6	1.1
Illnesses of siblings	0.0	0.0	0.1	-0.0	-0.1	-0.3
Neuroticism score	5.2	10.9	13.5	-3.2	-3.7	-3.0
Weight	0.2	1.1	2.7	-0.7	-0.5	1.6
Impedance of arm (right)	1.2	5.7	10.2	2.3	3.2	1.3
Arm fat percentage (right)	0.7	2.7	6.1	-1.3	-2.5	-0.6
Trunk fat-free mass	0.2	1.4	3.2	-0.7	0.6	1.8
Hip circumference	0.0	0.1	0.1	0.2	0.0	0.3
Time employed in main current job	1.2	1.4	2.4	1.6	1.1	0.8
Alcohol intake versus 10 years previously	0.5	0.7	2.0	0.3	-0.2	-1.4
Father’s age at death	0.8	1.1	2.2	-0.1	1.0	1.5
Worrier / anxious feelings	0.7	1.3	1.6	-0.9	-1.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	3.8	-1.9	-1.6	-0.6
Falls in the last year	1.0	1.3	2.3	-1.5	-1.3	0.1
Hair/balding pattern: Pattern 3	3.4	5.1	6.2	2.5	2.3	2.0
Number of live births	1.5	2.1	4.4	-1.4	-2.1	-0.2
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	13.8	0.5	3.2	3.7
Pulse rate	1.2	2.0	2.1	-1.4	-1.4	1.4
Happiness	4.7	5.7	9.7	-3.1	-2.5	-1.0
Noisy workplace	0.2	0.2	0.5	-0.4	0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.7	0.7	1.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.6	6.3	-0.8	-1.0	-2.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.9	0.0	-0.1
Asthma	0.3	0.6	1.3	-0.3	-1.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.2	-0.6	0.1
Medication: Cholesterol lowering	0.9	1.4	2.2	0.9	-1.5	-1.2
Depression (self-reported)	3.5	4.2	7.3	-2.7	-2.2	-0.6
Medication: Lansoprazole	0.7	0.8	1.8	1.3	0.6	0.3
Prospective memory result	1.4	1.7	4.2	-0.3	-0.9	-2.1
Lung cancer (father)	0.3	0.3	1.0	-0.1	-0.0	-1.0
Illnesses of mother	0.0	0.0	0.1	0.3	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	10.6	0.9	3.3	3.0
Pulse wave Arterial Stiffness index	1.2	1.4	2.6	-1.6	-1.2	0.3
Impedance of arm (left)	1.0	4.5	8.7	1.8	3.0	1.2
Arm fat mass (right)	0.5	2.0	4.3	-1.3	-2.1	0.4
Trunk predicted mass	0.2	1.3	3.1	-0.6	0.7	1.8
Standing height	2.1	21.2	30.6	2.2	5.5	5.3
Length of working week for main job	1.0	1.1	2.5	-0.7	0.5	1.6
Exposure to tobacco smoke at home	0.8	0.9	1.7	-0.9	-1.3	0.6
Breastfed as a baby	0.1	0.2	0.5	-0.1	-0.1	0.7
Tense / ‘highly strung’	4.0	6.7	8.9	-2.9	-3.0	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.0	-2.0	-1.2	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	-0.1	-0.1	-1.2
Birth weight of first child	1.5	2.8	4.6	0.6	1.9	2.1
Peak expiratory flow (PEF)	1.5	3.5	6.7	0.4	1.9	2.6
Pulse wave reflection index	1.0	1.2	2.4	-0.1	-1.1	-1.5
Ever highly irritable/argumentative for 2 days	2.4	2.8	4.2	-2.0	-1.1	-1.8
Loud music exposure frequency	0.3	0.3	0.8	0.5	0.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.1	0.7	-0.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.5	0.7	0.7
Blood clot in the leg (DVT)	0.4	0.5	0.6	-0.7	-0.7	-0.7
Medication: Paracetamol	1.3	2.1	3.6	-1.9	-1.5	-0.7
Headache pain in last month	1.7	3.0	4.1	-1.6	-2.0	-1.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.7	-0.9	0.8	0.8
Glaucoma (self-reported)	3.0	3.6	6.4	1.0	1.8	2.5
Gout (self-reported)	0.6	0.8	1.8	-1.3	-0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	0.1	-0.0	-0.6
Medication: Amlodipine	1.4	1.9	3.6	-1.2	-1.9	-0.8
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-0.7	-1.2	-0.5
Birth weight	2.0	4.4	10.7	-0.3	1.5	3.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.4	-1.0	-0.9	-1.2
High blood pressure (siblings)	0.2	0.3	0.7	-0.8	-0.3	-0.0
Forced vital capacity (FVC), Best measure	1.4	5.3	9.1	0.0	3.0	2.6
Body fat percentage	0.1	0.5	1.4	-0.3	-1.2	0.4
Leg fat percentage (right)	0.3	1.2	3.4	-0.3	-1.8	-0.2
Arm fat-free mass (right)	0.2	1.1	2.9	-0.6	0.1	1.7
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.3	-0.3	0.5
Comparative body size at age 10	0.4	1.1	1.5	-1.2	-1.2	0.5
Number of full brothers	2.1	2.6	4.1	-1.6	-2.0	-1.1
Worry too long after embarrassment	0.6	1.0	2.2	-0.8	-0.3	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.6	0.0	-0.2
Wheeze or whistling in the chest in last year	1.3	2.4	3.3	-1.4	-1.4	-1.8
Number of children fathered	0.3	0.4	0.7	-0.3	0.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	0.3	-1.0	-0.2
Age at first live birth	2.8	5.1	8.2	1.8	2.9	1.9
Pulse wave peak to peak time	2.1	2.5	3.9	2.0	1.9	0.4
Health satisfaction	4.1	5.3	6.0	-2.3	-2.5	-2.2
Shortness of breath walking on level ground	1.5	1.8	3.3	-1.2	-1.8	-0.8
Qualifications: College or University degree	0.5	1.7	3.9	0.8	2.0	0.7
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.2	0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-0.2	-0.7	-1.1
Emphysema/chronic bronchitis	0.8	0.9	1.8	0.8	-0.5	-1.3
Medication for pain relief, constipation, heartburn	0.6	1.0	1.4	1.2	1.1	0.7
Neck or shoulder pain in last month	1.3	1.8	3.2	-0.5	-1.4	-1.8
Medication: Blood pressure	0.4	0.7	1.6	1.3	0.6	0.4
Angina (self-reported)	0.3	0.4	1.1	1.0	0.3	-0.4
Migraine (self-reported)	1.4	1.7	2.4	-1.5	-1.6	-0.8
Medication: Ibuprofen	0.3	0.3	0.3	-0.5	-0.6	0.6
Medication: Allopurinol	1.1	1.4	2.9	-1.7	-1.1	0.4
Medication: Omeprazole	0.1	0.2	0.3	-0.3	-0.5	-0.3
Medication: Seretide 50 evohaler	0.6	0.7	2.1	0.2	-0.3	-1.4
Mean time to correctly identify matches	0.1	0.2	0.5	0.7	0.3	-0.2
Heart disease (mother)	2.9	3.5	3.9	-1.6	-2.0	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	0.7	-0.4	-0.6
Whole body fat mass	0.2	0.9	1.4	-0.6	-1.2	1.0
Leg fat mass (right)	0.3	1.1	2.3	-0.6	-1.5	0.8
Arm predicted mass (right)	0.3	1.4	3.8	-0.6	0.2	2.0
Pulse rate, automated reading	0.3	1.0	1.2	-0.8	-1.1	1.1
Alcohol intake frequency.	0.8	1.9	2.5	1.0	1.6	-1.4
Comparative height size at age 10	1.5	8.3	11.7	1.6	3.4	3.3
Number of full sisters	1.5	1.8	2.4	-1.4	-1.6	-0.9
Suffer from ‘nerves’	1.1	1.8	2.7	-1.0	-1.3	-1.7
Overall health rating	0.7	1.4	3.6	-0.8	-1.9	-0.2
Chest pain or discomfort	0.9	1.2	1.4	-1.2	-1.2	-0.9
Had major operations	2.0	2.3	2.7	-1.4	-1.6	-1.5
Age at last live birth	1.0	1.5	2.2	0.5	1.5	1.4
Family relationship satisfaction	3.2	3.9	9.2	-3.0	-1.3	-0.9
Leg pain on walking	0.9	1.1	1.8	-1.1	-1.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.0	-0.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.5	0.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.0	-0.0	0.9	1.4
Medication: Aspirin	0.6	0.8	1.7	0.7	-0.2	-1.3
Supplements: Vitamin C	0.8	0.9	2.2	1.5	0.8	-0.1
Knee pain experienced in last month	0.3	0.5	0.8	-0.6	-0.9	-0.5
Hypertension (Self-reported)	0.1	0.2	0.6	0.8	0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.1	-1.8	-1.6	0.3
Illnesses of father: Heart disease	0.6	0.8	1.3	0.8	-0.6	-1.2
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.5	0.6	0.3
Smoking status: Previous	0.3	0.4	0.8	-0.7	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.0	1.3	2.0	1.6
Whole body fat-free mass	0.2	1.3	3.2	-0.7	0.3	1.8
Leg fat-free mass (right)	0.2	1.1	2.7	-0.8	0.1	1.6
Arm fat percentage (left)	0.7	2.8	6.3	-1.4	-2.5	-0.5
Average weekly red wine intake	0.1	0.2	0.4	0.3	0.7	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.1	-0.7	0.1
Mood swings	4.6	8.3	11.4	-3.4	-3.4	-1.5
Loneliness, isolation	2.8	3.9	6.6	-1.6	-2.6	-1.5
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.2	-0.8	-0.5
Ever had bowel cancer screening	0.3	0.3	1.0	-0.1	0.1	1.0
Diabetes diagnosed by doctor	0.6	1.0	2.8	1.7	0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.1	-0.3	-1.5	-2.0
Friendships satisfaction	1.5	1.8	4.3	-2.1	-1.0	0.3
Qualifications: nursing, teaching	0.5	0.8	2.0	0.7	1.4	0.3
Commuting to job workplace: Walk	0.6	0.7	0.8	0.9	0.8	-0.7
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	-0.8	-0.3	-0.6
Medication for cholesterol	0.3	0.4	0.8	-0.7	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.3	0.6	-0.6
Back pain experienced in last month	0.1	0.2	0.3	0.5	-0.2	-0.5
Mineral and other dietary supplements	1.0	1.3	3.3	-0.4	-0.8	-1.8
Breast cancer (self-reported)	0.5	0.6	0.7	0.9	0.6	0.8
Asthma (self-reported)	0.1	0.3	0.7	-0.2	-0.8	-0.4
Osteoporosis (self-reported)	0.6	0.8	1.8	1.4	0.6	-0.3
Osteoarthritis (self-reported)	1.7	2.3	4.0	-0.8	-1.5	-2.0
Medication: Aspirin	0.8	1.0	1.9	1.4	0.3	-1.1
Medication: Gliclazide	3.2	3.6	7.6	2.8	1.7	0.5
Illnesses of father: None of the above (group 1)	0.6	0.8	1.3	0.1	1.0	1.1
Smoking status: Current	3.9	6.2	8.1	-1.8	-2.8	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	6.1	1.8	2.5	0.5
Whole body water mass	0.2	1.2	3.0	-0.7	0.3	1.7
Leg predicted mass (right)	0.2	1.1	2.8	-0.8	0.1	1.7
Arm fat mass (left)	0.5	2.0	4.1	-1.3	-2.0	0.5
Number of self-reported non-cancer illnesses	1.2	2.1	2.7	-1.0	-1.6	-1.6
Average weekly champagne plus white wine intake	1.6	2.1	4.8	-0.8	-1.0	-2.2
Miserableness	3.1	5.3	6.5	-2.5	-2.2	-2.1
Guilty feelings	10.9	16.4	24.6	-5.0	-4.7	-1.6
Wears glasses or contact lenses	4.1	4.7	6.0	2.5	2.3	1.7
Ever taken oral contraceptive pill	1.7	1.9	4.2	2.1	1.2	0.3
Hearing aid user	1.3	1.5	3.1	-1.0	-1.7	-0.7
Mother’s age at death	0.2	0.2	0.4	-0.2	-0.5	-0.6
Financial situation satisfaction	0.2	0.2	0.5	0.7	-0.0	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	0.0	0.5
Commuting to job workplace: Public transport	1.5	1.8	2.6	1.5	1.6	0.8
Eye problems/disorders: Glaucoma	4.7	5.5	12.1	0.8	2.0	3.5
Medication: Blood pressure	0.5	0.9	2.3	-0.1	-0.6	-1.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.8	-0.4	-1.1
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.5	0.7	0.8	1.9
High cholesterol (Self-reported)	0.5	0.9	1.6	0.9	-1.2	-0.6
Medication: Bendroflumethiazide	0.7	1.0	1.7	1.3	1.1	0.4
Medication: Paracetamol	0.4	0.7	1.1	-0.9	-1.1	0.1
Medication: Lisinopril	0.1	0.1	0.2	0.4	-0.1	0.1
Medication: Atorvastatin	0.8	0.9	1.4	0.3	-1.2	-1.1
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.4	0.1	1.0
Alcohol drinker status: Never	0.0	0.0	0.1	0.3	0.1	-0.1
Ever smoked	1.2	2.0	4.0	-0.8	-1.2	-2.0
Basal metabolic rate	0.2	1.3	3.2	-0.8	0.1	1.8
Leg fat percentage (left)	0.3	1.1	3.2	-0.4	-1.8	-0.2
Arm fat-free mass (left)	0.3	1.4	3.8	-0.4	0.3	2.0
Number of operations (self-reported)	0.3	0.4	0.9	-0.5	-0.5	-1.0
Average weekly beer plus cider intake	2.5	3.7	6.5	-2.1	-2.5	0.4
Irritability	1.5	2.6	3.9	-2.0	-1.8	-0.8
Risk taking	0.2	0.2	0.4	-0.3	-0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.0	1.0	1.4	0.5
Fractured/broken bones in last 5 years	0.6	0.8	2.4	-1.5	0.0	0.3
Age started oral contraceptive pill	0.4	0.5	1.1	0.4	1.1	0.2
Diastolic blood pressure, automated reading	0.2	0.7	2.0	-0.0	-0.3	1.4
Ever depressed for a whole week	1.4	1.8	4.4	-2.1	-0.7	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.1	-0.6	-0.5
Commuting to job workplace: Cycle	0.5	0.7	1.4	-1.2	-0.1	0.7
Myopia	1.1	1.5	1.8	1.2	1.3	1.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.3	0.5	0.8
Cholesterol lowering medication	0.1	0.2	0.5	0.3	-0.7	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	0.3	0.2	0.3
Pain experienced in last month	3.6	6.0	8.0	1.6	2.7	2.8
Supplements: Calcium	1.4	1.5	2.1	0.8	1.5	1.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.1	0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.4	-0.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.8	-0.5	-0.6
Heart disease (siblings)	0.9	1.1	1.6	0.7	1.1	1.2
Alcohol drinker status: Previous	0.9	1.1	1.6	1.2	1.3	0.5
Pack years of smoking	0.2	0.3	0.5	-0.5	-0.2	0.7
Impedance of whole body	1.7	8.5	13.8	2.8	3.7	1.9
Leg fat mass (left)	0.3	1.1	2.2	-0.6	-1.5	0.8
Arm predicted mass (left)	0.2	1.0	2.8	-0.5	0.1	1.7