Hub : Genes

TRMT10A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.2550 0.0590 1.5e-06 0.167 NA 0.150 NA 0.186 7.1e-12 NA 8.7e-11 NA 3.4e-13
2 GTEx Testis 0.3540 0.0750 6.6e-06 0.259 NA 0.259 NA 0.263 6.8e-12 NA 6.9e-12 NA 4.8e-12
3 METSIM Adipose 0.0542 0.0235 5.8e-03 -0.002 0.006 0.007 0.008 0.006 8.1e-01 0.036 2.8e-02 0.021 3.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.0 0.1 0.3 0.2 0.1
Bipolar Disorder or Schizophrenia 0.4 0.9 1.7 1.3 0.9 0.5
Depressed Affect (Nagel 2018) 3.4 7.2 10.1 -3.2 -3.0 -1.6
Depression (Nagel 2018) 2.6 4.0 6.8 -2.6 -2.3 -0.2
Intelligence (Savage-Jansen 2018) 1.6 5.0 7.2 1.3 2.7 2.5
Neuroticism (Nagel 2018) 3.9 9.2 13.5 -3.7 -3.1 -2.1
Schizophrenia (2018) 0.6 1.2 2.0 1.4 1.1 0.6
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 0.2 0.6 -0.2
Worry (Nagel 2018) 3.1 6.6 7.2 -2.6 -2.7 -2.4
Alzheimer’s Disease (in mother) 1.1 1.3 1.9 -1.3 -1.4 -0.5
Alzheimer’s Disease (in father) 0.7 0.8 2.1 0.0 0.6 1.4
Alzheimer’s Disease (including proxy) 0.9 1.3 2.3 -1.5 -0.8 1.0
Crohns Disease (2017) 0.5 1.1 1.8 0.8 -0.9 -1.4
Irritable Bowel Disease (IBD) 0.6 1.5 2.2 0.8 -1.3 -1.5
Ulcerative Colitis (UC) 0.7 1.2 1.7 0.9 -1.1 -1.3
Major Depression (MDD) 4.2 5.1 7.4 -2.7 -2.5 -1.2
Reaction Time 0.1 0.2 0.5 -0.0 -0.7 -0.0
Verbal and Numeric Reasoning (VNR) 1.7 4.2 6.3 1.5 2.5 2.0
Breast Cancer 0.2 0.5 1.1 -1.1 -0.2 -0.5
Ovarian Cancer 0.5 0.6 1.5 -0.3 0.6 1.2
Prostate Cancer 1.2 1.6 2.8 -1.4 -1.7 -0.5
Age at First Birth 3.7 5.4 7.3 2.0 2.2 2.7
Bipolar Disorder (2011) 0.1 0.1 0.3 0.5 0.0 0.4
Body Mass Index (BMI) (2010) 0.7 0.9 2.3 -0.3 -1.5 -0.6
Coronary Artery Disease (CAD) 0.4 0.5 0.6 0.8 0.7 0.7
Crohns Disease (2012) 0.8 1.3 3.0 1.7 0.8 0.5
Mean Putamen Volume 0.3 0.3 0.5 -0.7 0.3 -0.5
Fasting Glucose 0.3 0.3 0.7 0.4 0.9 0.4
HbA1C 0.8 0.9 2.1 0.7 1.5 -0.0
HDL Cholesterol 0.8 1.4 2.1 0.9 1.4 1.1
LDL Cholesterol 1.2 2.0 3.6 1.9 0.4 -1.5
Lupus 2.5 3.8 9.0 -1.2 -1.0 -3.0
Neuroticism (2016) 2.8 4.1 5.5 -2.4 -2.1 -1.5
Primary Biliary Cirrhosis 0.4 0.5 1.2 1.1 0.6 -0.1
Rheumatoid Arthritis 0.7 0.9 1.3 1.2 1.0 0.7
Schizophrenia (2014) 0.2 0.4 0.6 0.7 0.7 0.4
Triglycerides 2.0 3.3 7.0 -0.9 -1.5 -2.6
Type 2 Diabetes (T2D) (2012) 1.3 1.5 2.6 -0.5 -1.6 -1.2
Ulcerative Colitis 0.1 0.1 0.3 0.6 -0.3 -0.0
Blood Eosinophil Count 0.2 1.8 3.1 -1.8 -1.0 1.0
Blood Platelet Count 0.6 7.1 18.8 -1.6 0.1 4.3
Blood Red Count 0.4 3.4 5.8 -2.4 -2.1 0.5
Blood White Count 0.1 1.1 1.8 -1.0 -0.6 1.3
Heel T-Score 0.4 3.6 7.5 -2.7 -1.7 -0.6
BMI 0.7 3.9 8.4 -1.8 -2.9 -0.4
Height 1.8 34.7 51.7 3.4 7.2 6.4
Waist Hip Ratio (WHR) 1.5 6.9 14.3 -2.5 -3.8 -0.1
Systolic Blood Pressure 0.6 3.1 4.8 2.2 1.9 -1.0
Smoking Status 2.2 5.3 7.9 -1.3 -2.8 -2.6
Allergy or Eczema 0.6 1.6 3.4 -0.0 1.2 1.9
Cardiovascular Disease 0.1 0.4 0.6 0.8 -0.8 -0.1
Hypothyroidism (self reported) 0.3 0.8 1.1 -1.0 -0.6 -1.0
Respiratory disease 0.0 0.1 0.2 -0.2 -0.4 -0.2
Type 2 Diabetes (T2D) (2018) 0.5 0.8 2.5 1.6 -0.1 0.2
Lung FEV1/FVC ratio 0.2 1.2 1.5 1.2 0.9 1.1
Lung FVC 0.6 3.2 8.5 -2.9 -0.9 -0.4
Neuroticism 2.8 6.7 8.2 -2.9 -2.7 -2.2
Chronotype (morning person) 0.1 0.2 0.7 -0.2 0.8 0.3
Hair Pigment 0.0 0.3 0.6 0.8 0.4 -0.0
Tanning 0.1 0.8 1.3 1.0 1.2 0.4
Hand grip strength (left) 0.6 1.6 3.8 0.4 1.9 0.8
Number of treatments/medications taken 0.1 0.1 0.2 0.5 -0.1 0.4
Average weekly spirits intake 1.4 1.7 3.0 -1.7 -1.2 0.8
Sensitivity / hurt feelings 0.7 1.2 2.6 -0.7 -0.8 -1.6
Frequency of depressed mood in last 2 weeks 1.9 2.7 4.4 -1.9 -2.1 -0.1
Hearing difficulty/problems: Yes 0.3 0.4 1.3 1.1 0.2 -0.0
Relative age of first facial hair 0.8 1.6 3.5 -1.9 -0.6 0.9
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.1 0.4 -0.1 -0.2
Ever used hormone-replacement therapy (HRT) 1.5 1.9 4.2 -0.4 -1.2 -2.1
Ever had hysterectomy (womb removed) 0.7 0.8 1.1 -1.1 -1.0 0.4
Systolic blood pressure, automated reading 0.6 1.7 2.7 1.6 1.6 0.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.2 0.4 -0.4 -0.5
Angina 0.5 0.7 1.5 1.2 0.4 -0.6
Medication for hormone replacement therapy 0.3 0.3 0.8 -0.4 -0.2 -0.9
Vitamin and mineral supplements 1.0 1.3 2.4 -0.8 -0.9 -1.6
Supplements: Zinc 0.3 0.4 0.8 0.5 0.0 -0.9
Medication: Co-codamol 0.8 0.9 1.6 0.1 1.1 1.3
Medication: Metformin 1.1 1.5 4.2 2.0 0.4 -0.6
Diabetes (father) 0.2 0.2 0.3 -0.1 -0.5 -0.5
Diabetes (mother) 0.1 0.1 0.2 0.3 -0.5 0.0
Severe depression (siblings) 0.7 0.8 2.0 -0.3 -0.4 -1.4
Pack years adult smoking proportion 0.5 0.7 1.0 -1.0 -0.7 0.8
Impedance of leg (right) 1.8 8.6 11.8 3.4 3.4 1.6
Leg fat-free mass (left) 0.2 1.2 3.0 -0.8 0.1 1.7
Trunk fat percentage 0.1 0.4 1.0 0.0 -0.4 1.0
Hand grip strength (right) 0.4 1.2 1.9 -0.3 1.4 1.3
Townsend deprivation index at recruitment 2.3 3.2 5.0 -1.6 -2.2 -1.5
Current tobacco smoking 2.9 4.7 8.3 -1.2 -2.1 -2.9
Average weekly fortified wine intake 0.7 0.8 1.4 -0.6 -1.2 -0.8
Maternal smoking around birth 1.7 2.4 6.2 0.1 -1.0 -2.5
Fed-up feelings 2.4 4.3 6.5 -2.5 -2.3 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.5 4.7 7.1 -2.5 -2.7 -0.9
Relative age voice broke 0.3 0.5 0.7 -0.8 -0.7 0.5
Taking other prescription medications 0.5 0.7 1.9 -0.3 -0.5 1.4
Age when periods started (menarche) 0.2 0.5 0.9 0.9 0.6 -0.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 -0.4 -1.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.6 1.6 0.5 -0.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.5 -0.6 -0.7 -0.7
Qualifications: CSEs or equivalent 0.6 0.7 1.4 -0.6 -1.2 -0.7
Serious illness, injury or assault to yourself 0.3 0.4 1.0 0.5 -0.1 1.0
High blood pressure 0.0 0.0 0.0 0.2 -0.2 0.1
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.2 -0.0 1.0 1.5
Multivitamins +/- minerals 0.7 0.9 2.0 -0.6 0.6 1.4
Stomach or abdominal pain in last month 1.5 1.9 3.0 -1.7 -1.6 0.1
Supplements: Glucosamine 1.2 1.6 3.7 0.4 1.0 1.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.7 -0.9 -0.1 0.6
Medication: Atenolol 0.6 0.8 1.9 1.4 -0.4 -0.6
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.4 -0.7 -0.5
Sitting height 3.9 27.7 39.3 2.8 6.3 6.0
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 0.4 0.1 0.0
High blood pressure (mother) 0.1 0.1 0.3 0.1 0.6 -0.0
Body mass index (BMI) 1.1 4.8 10.1 -1.9 -3.2 -0.8
Impedance of leg (left) 2.1 10.1 14.6 3.5 3.8 1.9
Leg predicted mass (left) 0.2 1.3 3.2 -0.8 -0.0 1.8
Trunk fat mass 0.2 0.8 2.1 -0.2 -0.4 1.5
Waist circumference 0.8 3.1 7.1 -1.5 -2.7 -0.1
Number of incorrect matches in round 0.2 0.3 0.5 -0.5 0.4 0.7
Past tobacco smoking 1.1 2.1 2.9 1.4 1.7 1.2
Alcohol usually taken with meals 0.1 0.2 0.3 0.3 0.5 -0.5
Nervous feelings 4.3 8.0 8.9 -2.6 -3.0 -2.9
Frequency of tenseness / restlessness in last 2 weeks 2.3 3.6 5.6 -2.2 -2.4 -0.4
Hearing difficulty/problems with background noise 0.3 0.6 1.3 0.6 -0.2 -1.1
Hair/balding pattern: Pattern 2 0.6 0.8 1.1 1.0 0.6 1.1
Had menopause 0.3 0.3 0.4 -0.5 -0.5 -0.7
Had other major operations 0.1 0.1 0.2 0.5 0.2 -0.2
Forced vital capacity (FVC) 1.6 6.0 9.7 -0.2 2.9 3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 1.0 0.2 -0.6
Ever unenthusiastic/disinterested for a whole week 3.3 4.0 9.6 -3.1 -1.6 -0.2
Qualifications: None of the above 0.5 1.0 2.1 -0.3 -1.4 -0.9
Financial difficulties in last 2 years 0.1 0.1 0.2 0.4 0.1 -0.4
Mouth/teeth dental problems 0.2 0.4 0.5 0.6 0.7 0.5
Heart attack 0.3 0.4 0.9 -0.5 -0.9 -0.3
Allergy 0.0 0.1 0.1 0.3 -0.0 -0.4
Pain all over the body in last month 0.2 0.2 0.4 0.6 0.3 0.4
Diabetes (self-reported) 0.4 0.6 1.5 1.2 -0.2 -0.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 1.7 1.0 1.3 0.6
Medication: Ramipril 0.2 0.3 0.7 0.1 0.2 0.8
Medication: Simvastatin 0.9 1.4 3.8 1.9 0.3 -0.5
Fluid intelligence score 0.7 1.5 2.7 0.9 1.6 1.1
Illnesses of siblings 0.0 0.0 0.1 -0.0 -0.1 -0.3
Neuroticism score 5.2 10.9 13.5 -3.2 -3.7 -3.0
Weight 0.2 1.1 2.7 -0.7 -0.5 1.6
Impedance of arm (right) 1.2 5.7 10.2 2.3 3.2 1.3
Arm fat percentage (right) 0.7 2.7 6.1 -1.3 -2.5 -0.6
Trunk fat-free mass 0.2 1.4 3.2 -0.7 0.6 1.8
Hip circumference 0.0 0.1 0.1 0.2 0.0 0.3
Time employed in main current job 1.2 1.4 2.4 1.6 1.1 0.8
Alcohol intake versus 10 years previously 0.5 0.7 2.0 0.3 -0.2 -1.4
Father’s age at death 0.8 1.1 2.2 -0.1 1.0 1.5
Worrier / anxious feelings 0.7 1.3 1.6 -0.9 -1.3 -1.2
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 3.8 -1.9 -1.6 -0.6
Falls in the last year 1.0 1.3 2.3 -1.5 -1.3 0.1
Hair/balding pattern: Pattern 3 3.4 5.1 6.2 2.5 2.3 2.0
Number of live births 1.5 2.1 4.4 -1.4 -2.1 -0.2
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 13.8 0.5 3.2 3.7
Pulse rate 1.2 2.0 2.1 -1.4 -1.4 1.4
Happiness 4.7 5.7 9.7 -3.1 -2.5 -1.0
Noisy workplace 0.2 0.2 0.5 -0.4 0.2 -0.7
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.7 0.7 1.3 -0.4
Serious illness, injury or assault of a close relative in last 2 years 2.2 2.6 6.3 -0.8 -1.0 -2.5
Mouth/teeth dental problems: Dentures 0.1 0.2 0.7 0.9 0.0 -0.1
Asthma 0.3 0.6 1.3 -0.3 -1.1 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.4 -0.2 -0.6 0.1
Medication: Cholesterol lowering 0.9 1.4 2.2 0.9 -1.5 -1.2
Depression (self-reported) 3.5 4.2 7.3 -2.7 -2.2 -0.6
Medication: Lansoprazole 0.7 0.8 1.8 1.3 0.6 0.3
Prospective memory result 1.4 1.7 4.2 -0.3 -0.9 -2.1
Lung cancer (father) 0.3 0.3 1.0 -0.1 -0.0 -1.0
Illnesses of mother 0.0 0.0 0.1 0.3 0.1 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.7 10.6 0.9 3.3 3.0
Pulse wave Arterial Stiffness index 1.2 1.4 2.6 -1.6 -1.2 0.3
Impedance of arm (left) 1.0 4.5 8.7 1.8 3.0 1.2
Arm fat mass (right) 0.5 2.0 4.3 -1.3 -2.1 0.4
Trunk predicted mass 0.2 1.3 3.1 -0.6 0.7 1.8
Standing height 2.1 21.2 30.6 2.2 5.5 5.3
Length of working week for main job 1.0 1.1 2.5 -0.7 0.5 1.6
Exposure to tobacco smoke at home 0.8 0.9 1.7 -0.9 -1.3 0.6
Breastfed as a baby 0.1 0.2 0.5 -0.1 -0.1 0.7
Tense / ‘highly strung’ 4.0 6.7 8.9 -2.9 -3.0 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.0 -2.0 -1.2 -0.3
Hair/balding pattern: Pattern 4 0.2 0.5 1.5 -0.1 -0.1 -1.2
Birth weight of first child 1.5 2.8 4.6 0.6 1.9 2.1
Peak expiratory flow (PEF) 1.5 3.5 6.7 0.4 1.9 2.6
Pulse wave reflection index 1.0 1.2 2.4 -0.1 -1.1 -1.5
Ever highly irritable/argumentative for 2 days 2.4 2.8 4.2 -2.0 -1.1 -1.8
Loud music exposure frequency 0.3 0.3 0.8 0.5 0.1 -0.9
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 -0.1 0.7 -0.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.6 0.5 0.7 0.7
Blood clot in the leg (DVT) 0.4 0.5 0.6 -0.7 -0.7 -0.7
Medication: Paracetamol 1.3 2.1 3.6 -1.9 -1.5 -0.7
Headache pain in last month 1.7 3.0 4.1 -1.6 -2.0 -1.5
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 0.7 -0.9 0.8 0.8
Glaucoma (self-reported) 3.0 3.6 6.4 1.0 1.8 2.5
Gout (self-reported) 0.6 0.8 1.8 -1.3 -0.6 0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.4 0.1 -0.0 -0.6
Medication: Amlodipine 1.4 1.9 3.6 -1.2 -1.9 -0.8
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.6 -0.7 -1.2 -0.5
Birth weight 2.0 4.4 10.7 -0.3 1.5 3.3
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.4 -1.0 -0.9 -1.2
High blood pressure (siblings) 0.2 0.3 0.7 -0.8 -0.3 -0.0
Forced vital capacity (FVC), Best measure 1.4 5.3 9.1 0.0 3.0 2.6
Body fat percentage 0.1 0.5 1.4 -0.3 -1.2 0.4
Leg fat percentage (right) 0.3 1.2 3.4 -0.3 -1.8 -0.2
Arm fat-free mass (right) 0.2 1.1 2.9 -0.6 0.1 1.7
Exposure to tobacco smoke outside home 0.1 0.1 0.3 -0.3 -0.3 0.5
Comparative body size at age 10 0.4 1.1 1.5 -1.2 -1.2 0.5
Number of full brothers 2.1 2.6 4.1 -1.6 -2.0 -1.1
Worry too long after embarrassment 0.6 1.0 2.2 -0.8 -0.3 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.6 0.0 -0.2
Wheeze or whistling in the chest in last year 1.3 2.4 3.3 -1.4 -1.4 -1.8
Number of children fathered 0.3 0.4 0.7 -0.3 0.6 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 0.3 -1.0 -0.2
Age at first live birth 2.8 5.1 8.2 1.8 2.9 1.9
Pulse wave peak to peak time 2.1 2.5 3.9 2.0 1.9 0.4
Health satisfaction 4.1 5.3 6.0 -2.3 -2.5 -2.2
Shortness of breath walking on level ground 1.5 1.8 3.3 -1.2 -1.8 -0.8
Qualifications: College or University degree 0.5 1.7 3.9 0.8 2.0 0.7
Eye problems/disorders: None of the above 0.0 0.0 0.1 -0.2 0.2 0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.2 -0.2 -0.7 -1.1
Emphysema/chronic bronchitis 0.8 0.9 1.8 0.8 -0.5 -1.3
Medication for pain relief, constipation, heartburn 0.6 1.0 1.4 1.2 1.1 0.7
Neck or shoulder pain in last month 1.3 1.8 3.2 -0.5 -1.4 -1.8
Medication: Blood pressure 0.4 0.7 1.6 1.3 0.6 0.4
Angina (self-reported) 0.3 0.4 1.1 1.0 0.3 -0.4
Migraine (self-reported) 1.4 1.7 2.4 -1.5 -1.6 -0.8
Medication: Ibuprofen 0.3 0.3 0.3 -0.5 -0.6 0.6
Medication: Allopurinol 1.1 1.4 2.9 -1.7 -1.1 0.4
Medication: Omeprazole 0.1 0.2 0.3 -0.3 -0.5 -0.3
Medication: Seretide 50 evohaler 0.6 0.7 2.1 0.2 -0.3 -1.4
Mean time to correctly identify matches 0.1 0.2 0.5 0.7 0.3 -0.2
Heart disease (mother) 2.9 3.5 3.9 -1.6 -2.0 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.5 0.7 -0.4 -0.6
Whole body fat mass 0.2 0.9 1.4 -0.6 -1.2 1.0
Leg fat mass (right) 0.3 1.1 2.3 -0.6 -1.5 0.8
Arm predicted mass (right) 0.3 1.4 3.8 -0.6 0.2 2.0
Pulse rate, automated reading 0.3 1.0 1.2 -0.8 -1.1 1.1
Alcohol intake frequency. 0.8 1.9 2.5 1.0 1.6 -1.4
Comparative height size at age 10 1.5 8.3 11.7 1.6 3.4 3.3
Number of full sisters 1.5 1.8 2.4 -1.4 -1.6 -0.9
Suffer from ‘nerves’ 1.1 1.8 2.7 -1.0 -1.3 -1.7
Overall health rating 0.7 1.4 3.6 -0.8 -1.9 -0.2
Chest pain or discomfort 0.9 1.2 1.4 -1.2 -1.2 -0.9
Had major operations 2.0 2.3 2.7 -1.4 -1.6 -1.5
Age at last live birth 1.0 1.5 2.2 0.5 1.5 1.4
Family relationship satisfaction 3.2 3.9 9.2 -3.0 -1.3 -0.9
Leg pain on walking 0.9 1.1 1.8 -1.1 -1.4 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.1 0.0 -0.4 -0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.5 0.2 0.4
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.0 -0.0 0.9 1.4
Medication: Aspirin 0.6 0.8 1.7 0.7 -0.2 -1.3
Supplements: Vitamin C 0.8 0.9 2.2 1.5 0.8 -0.1
Knee pain experienced in last month 0.3 0.5 0.8 -0.6 -0.9 -0.5
Hypertension (Self-reported) 0.1 0.2 0.6 0.8 0.1 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 3.1 -1.8 -1.6 0.3
Illnesses of father: Heart disease 0.6 0.8 1.3 0.8 -0.6 -1.2
Illnesses of siblings: Diabetes 0.2 0.2 0.3 0.5 0.6 0.3
Smoking status: Previous 0.3 0.4 0.8 -0.7 -0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 4.0 1.3 2.0 1.6
Whole body fat-free mass 0.2 1.3 3.2 -0.7 0.3 1.8
Leg fat-free mass (right) 0.2 1.1 2.7 -0.8 0.1 1.6
Arm fat percentage (left) 0.7 2.8 6.3 -1.4 -2.5 -0.5
Average weekly red wine intake 0.1 0.2 0.4 0.3 0.7 0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 -1.1 -0.7 0.1
Mood swings 4.6 8.3 11.4 -3.4 -3.4 -1.5
Loneliness, isolation 2.8 3.9 6.6 -1.6 -2.6 -1.5
Long-standing illness, disability or infirmity 0.2 0.3 0.6 -0.2 -0.8 -0.5
Ever had bowel cancer screening 0.3 0.3 1.0 -0.1 0.1 1.0
Diabetes diagnosed by doctor 0.6 1.0 2.8 1.7 0.3 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.1 4.1 -0.3 -1.5 -2.0
Friendships satisfaction 1.5 1.8 4.3 -2.1 -1.0 0.3
Qualifications: nursing, teaching 0.5 0.8 2.0 0.7 1.4 0.3
Commuting to job workplace: Walk 0.6 0.7 0.8 0.9 0.8 -0.7
Eye problems/disorders: Cataract 0.1 0.1 0.2 -0.1 -0.2 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.7 -0.8 -0.3 -0.6
Medication for cholesterol 0.3 0.4 0.8 -0.7 0.2 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.4 0.3 0.6 -0.6
Back pain experienced in last month 0.1 0.2 0.3 0.5 -0.2 -0.5
Mineral and other dietary supplements 1.0 1.3 3.3 -0.4 -0.8 -1.8
Breast cancer (self-reported) 0.5 0.6 0.7 0.9 0.6 0.8
Asthma (self-reported) 0.1 0.3 0.7 -0.2 -0.8 -0.4
Osteoporosis (self-reported) 0.6 0.8 1.8 1.4 0.6 -0.3
Osteoarthritis (self-reported) 1.7 2.3 4.0 -0.8 -1.5 -2.0
Medication: Aspirin 0.8 1.0 1.9 1.4 0.3 -1.1
Medication: Gliclazide 3.2 3.6 7.6 2.8 1.7 0.5
Illnesses of father: None of the above (group 1) 0.6 0.8 1.3 0.1 1.0 1.1
Smoking status: Current 3.9 6.2 8.1 -1.8 -2.8 -2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 6.1 1.8 2.5 0.5
Whole body water mass 0.2 1.2 3.0 -0.7 0.3 1.7
Leg predicted mass (right) 0.2 1.1 2.8 -0.8 0.1 1.7
Arm fat mass (left) 0.5 2.0 4.1 -1.3 -2.0 0.5
Number of self-reported non-cancer illnesses 1.2 2.1 2.7 -1.0 -1.6 -1.6
Average weekly champagne plus white wine intake 1.6 2.1 4.8 -0.8 -1.0 -2.2
Miserableness 3.1 5.3 6.5 -2.5 -2.2 -2.1
Guilty feelings 10.9 16.4 24.6 -5.0 -4.7 -1.6
Wears glasses or contact lenses 4.1 4.7 6.0 2.5 2.3 1.7
Ever taken oral contraceptive pill 1.7 1.9 4.2 2.1 1.2 0.3
Hearing aid user 1.3 1.5 3.1 -1.0 -1.7 -0.7
Mother’s age at death 0.2 0.2 0.4 -0.2 -0.5 -0.6
Financial situation satisfaction 0.2 0.2 0.5 0.7 -0.0 -0.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.3 0.0 0.5
Commuting to job workplace: Public transport 1.5 1.8 2.6 1.5 1.6 0.8
Eye problems/disorders: Glaucoma 4.7 5.5 12.1 0.8 2.0 3.5
Medication: Blood pressure 0.5 0.9 2.3 -0.1 -0.6 -1.5
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.1 0.8 -0.4 -1.1
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.5 0.7 0.8 1.9
High cholesterol (Self-reported) 0.5 0.9 1.6 0.9 -1.2 -0.6
Medication: Bendroflumethiazide 0.7 1.0 1.7 1.3 1.1 0.4
Medication: Paracetamol 0.4 0.7 1.1 -0.9 -1.1 0.1
Medication: Lisinopril 0.1 0.1 0.2 0.4 -0.1 0.1
Medication: Atorvastatin 0.8 0.9 1.4 0.3 -1.2 -1.1
Illnesses of father: High blood pressure 0.3 0.4 1.1 0.4 0.1 1.0
Alcohol drinker status: Never 0.0 0.0 0.1 0.3 0.1 -0.1
Ever smoked 1.2 2.0 4.0 -0.8 -1.2 -2.0
Basal metabolic rate 0.2 1.3 3.2 -0.8 0.1 1.8
Leg fat percentage (left) 0.3 1.1 3.2 -0.4 -1.8 -0.2
Arm fat-free mass (left) 0.3 1.4 3.8 -0.4 0.3 2.0
Number of operations (self-reported) 0.3 0.4 0.9 -0.5 -0.5 -1.0
Average weekly beer plus cider intake 2.5 3.7 6.5 -2.1 -2.5 0.4
Irritability 1.5 2.6 3.9 -2.0 -1.8 -0.8
Risk taking 0.2 0.2 0.4 -0.3 -0.4 -0.7
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.0 1.0 1.4 0.5
Fractured/broken bones in last 5 years 0.6 0.8 2.4 -1.5 0.0 0.3
Age started oral contraceptive pill 0.4 0.5 1.1 0.4 1.1 0.2
Diastolic blood pressure, automated reading 0.2 0.7 2.0 -0.0 -0.3 1.4
Ever depressed for a whole week 1.4 1.8 4.4 -2.1 -0.7 -0.6
Unable to work because of sickness or disability 0.1 0.2 0.3 -0.1 -0.6 -0.5
Commuting to job workplace: Cycle 0.5 0.7 1.4 -1.2 -0.1 0.7
Myopia 1.1 1.5 1.8 1.2 1.3 1.2
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.7 -0.3 0.5 0.8
Cholesterol lowering medication 0.1 0.2 0.5 0.3 -0.7 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.1 0.3 0.2 0.3
Pain experienced in last month 3.6 6.0 8.0 1.6 2.7 2.8
Supplements: Calcium 1.4 1.5 2.1 0.8 1.5 1.3
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 -0.1 0.7 0.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 -0.4 -0.8 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 -0.8 -0.5 -0.6
Heart disease (siblings) 0.9 1.1 1.6 0.7 1.1 1.2
Alcohol drinker status: Previous 0.9 1.1 1.6 1.2 1.3 0.5
Pack years of smoking 0.2 0.3 0.5 -0.5 -0.2 0.7
Impedance of whole body 1.7 8.5 13.8 2.8 3.7 1.9
Leg fat mass (left) 0.3 1.1 2.2 -0.6 -1.5 0.8
Arm predicted mass (left) 0.2 1.0 2.8 -0.5 0.1 1.7