TWAS hub - TRMT10A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.2550	0.0590	1.5e-06	0.167	NA	0.150	NA	0.186	7.1e-12	NA	8.7e-11	NA	3.4e-13
2	GTEx	Testis	0.3540	0.0750	6.6e-06	0.259	NA	0.259	NA	0.263	6.8e-12	NA	6.9e-12	NA	4.8e-12
3	METSIM	Adipose	0.0542	0.0235	5.8e-03	-0.002	0.006	0.007	0.008	0.006	8.1e-01	0.036	2.8e-02	0.021	3.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Guilty feelings	10.9	16.4	24.6	-5.0	-4.7	-1.6
Neuroticism score	5.2	10.9	13.5	-3.2	-3.7	-3.0
Happiness	4.7	5.7	9.7	-3.1	-2.5	-1.0
Eye problems/disorders: Glaucoma	4.7	5.5	12.1	0.8	2.0	3.5
Mood swings	4.6	8.3	11.4	-3.4	-3.4	-1.5
Nervous feelings	4.3	8.0	8.9	-2.6	-3.0	-2.9
Major Depression (MDD)	4.2	5.1	7.4	-2.7	-2.5	-1.2
Health satisfaction	4.1	5.3	6.0	-2.3	-2.5	-2.2
Wears glasses or contact lenses	4.1	4.7	6.0	2.5	2.3	1.7
Tense / ‘highly strung’	4.0	6.7	8.9	-2.9	-3.0	-1.6
Neuroticism (Nagel 2018)	3.9	9.2	13.5	-3.7	-3.1	-2.1
Sitting height	3.9	27.7	39.3	2.8	6.3	6.0
Smoking status: Current	3.9	6.2	8.1	-1.8	-2.8	-2.8
Age at First Birth	3.7	5.4	7.3	2.0	2.2	2.7
Pain experienced in last month	3.6	6.0	8.0	1.6	2.7	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.5	4.7	7.1	-2.5	-2.7	-0.9
Depression (self-reported)	3.5	4.2	7.3	-2.7	-2.2	-0.6
Depressed Affect (Nagel 2018)	3.4	7.2	10.1	-3.2	-3.0	-1.6
Hair/balding pattern: Pattern 3	3.4	5.1	6.2	2.5	2.3	2.0
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	9.6	-3.1	-1.6	-0.2
Family relationship satisfaction	3.2	3.9	9.2	-3.0	-1.3	-0.9
Medication: Gliclazide	3.2	3.6	7.6	2.8	1.7	0.5
Worry (Nagel 2018)	3.1	6.6	7.2	-2.6	-2.7	-2.4
Miserableness	3.1	5.3	6.5	-2.5	-2.2	-2.1
Glaucoma (self-reported)	3.0	3.6	6.4	1.0	1.8	2.5
Current tobacco smoking	2.9	4.7	8.3	-1.2	-2.1	-2.9
Heart disease (mother)	2.9	3.5	3.9	-1.6	-2.0	-2.0
Neuroticism (2016)	2.8	4.1	5.5	-2.4	-2.1	-1.5
Neuroticism	2.8	6.7	8.2	-2.9	-2.7	-2.2
Age at first live birth	2.8	5.1	8.2	1.8	2.9	1.9
Loneliness, isolation	2.8	3.9	6.6	-1.6	-2.6	-1.5
Depression (Nagel 2018)	2.6	4.0	6.8	-2.6	-2.3	-0.2
Lupus	2.5	3.8	9.0	-1.2	-1.0	-3.0
Average weekly beer plus cider intake	2.5	3.7	6.5	-2.1	-2.5	0.4
Fed-up feelings	2.4	4.3	6.5	-2.5	-2.3	-1.0
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	13.8	0.5	3.2	3.7
Ever highly irritable/argumentative for 2 days	2.4	2.8	4.2	-2.0	-1.1	-1.8
Townsend deprivation index at recruitment	2.3	3.2	5.0	-1.6	-2.2	-1.5
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	5.6	-2.2	-2.4	-0.4
Smoking Status	2.2	5.3	7.9	-1.3	-2.8	-2.6
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.6	6.3	-0.8	-1.0	-2.5
Impedance of leg (left)	2.1	10.1	14.6	3.5	3.8	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.7	10.6	0.9	3.3	3.0
Standing height	2.1	21.2	30.6	2.2	5.5	5.3
Number of full brothers	2.1	2.6	4.1	-1.6	-2.0	-1.1
Pulse wave peak to peak time	2.1	2.5	3.9	2.0	1.9	0.4
Triglycerides	2.0	3.3	7.0	-0.9	-1.5	-2.6
Birth weight	2.0	4.4	10.7	-0.3	1.5	3.3
Had major operations	2.0	2.3	2.7	-1.4	-1.6	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.1	-0.3	-1.5	-2.0
Frequency of depressed mood in last 2 weeks	1.9	2.7	4.4	-1.9	-2.1	-0.1
Height	1.8	34.7	51.7	3.4	7.2	6.4
Impedance of leg (right)	1.8	8.6	11.8	3.4	3.4	1.6
Verbal and Numeric Reasoning (VNR)	1.7	4.2	6.3	1.5	2.5	2.0
Maternal smoking around birth	1.7	2.4	6.2	0.1	-1.0	-2.5
Headache pain in last month	1.7	3.0	4.1	-1.6	-2.0	-1.5
Osteoarthritis (self-reported)	1.7	2.3	4.0	-0.8	-1.5	-2.0
Ever taken oral contraceptive pill	1.7	1.9	4.2	2.1	1.2	0.3
Impedance of whole body	1.7	8.5	13.8	2.8	3.7	1.9
Intelligence (Savage-Jansen 2018)	1.6	5.0	7.2	1.3	2.7	2.5
Forced vital capacity (FVC)	1.6	6.0	9.7	-0.2	2.9	3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.1	-1.8	-1.6	0.3
Average weekly champagne plus white wine intake	1.6	2.1	4.8	-0.8	-1.0	-2.2
Waist Hip Ratio (WHR)	1.5	6.9	14.3	-2.5	-3.8	-0.1
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.2	-0.4	-1.2	-2.1
Stomach or abdominal pain in last month	1.5	1.9	3.0	-1.7	-1.6	0.1
Number of live births	1.5	2.1	4.4	-1.4	-2.1	-0.2
Birth weight of first child	1.5	2.8	4.6	0.6	1.9	2.1
Peak expiratory flow (PEF)	1.5	3.5	6.7	0.4	1.9	2.6
Shortness of breath walking on level ground	1.5	1.8	3.3	-1.2	-1.8	-0.8
Comparative height size at age 10	1.5	8.3	11.7	1.6	3.4	3.3
Number of full sisters	1.5	1.8	2.4	-1.4	-1.6	-0.9
Friendships satisfaction	1.5	1.8	4.3	-2.1	-1.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	6.1	1.8	2.5	0.5
Commuting to job workplace: Public transport	1.5	1.8	2.6	1.5	1.6	0.8
Irritability	1.5	2.6	3.9	-2.0	-1.8	-0.8
Average weekly spirits intake	1.4	1.7	3.0	-1.7	-1.2	0.8
Prospective memory result	1.4	1.7	4.2	-0.3	-0.9	-2.1
Medication: Amlodipine	1.4	1.9	3.6	-1.2	-1.9	-0.8
Forced vital capacity (FVC), Best measure	1.4	5.3	9.1	0.0	3.0	2.6
Migraine (self-reported)	1.4	1.7	2.4	-1.5	-1.6	-0.8
Ever depressed for a whole week	1.4	1.8	4.4	-2.1	-0.7	-0.6
Supplements: Calcium	1.4	1.5	2.1	0.8	1.5	1.3
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.6	-0.5	-1.6	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	3.8	-1.9	-1.6	-0.6
Medication: Paracetamol	1.3	2.1	3.6	-1.9	-1.5	-0.7
Wheeze or whistling in the chest in last year	1.3	2.4	3.3	-1.4	-1.4	-1.8
Neck or shoulder pain in last month	1.3	1.8	3.2	-0.5	-1.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.0	1.3	2.0	1.6
Hearing aid user	1.3	1.5	3.1	-1.0	-1.7	-0.7
Prostate Cancer	1.2	1.6	2.8	-1.4	-1.7	-0.5
LDL Cholesterol	1.2	2.0	3.6	1.9	0.4	-1.5
Supplements: Glucosamine	1.2	1.6	3.7	0.4	1.0	1.9
Impedance of arm (right)	1.2	5.7	10.2	2.3	3.2	1.3
Time employed in main current job	1.2	1.4	2.4	1.6	1.1	0.8
Pulse rate	1.2	2.0	2.1	-1.4	-1.4	1.4
Pulse wave Arterial Stiffness index	1.2	1.4	2.6	-1.6	-1.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.0	-2.0	-1.2	-0.3
Number of self-reported non-cancer illnesses	1.2	2.1	2.7	-1.0	-1.6	-1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.5	0.7	0.8	1.9
Ever smoked	1.2	2.0	4.0	-0.8	-1.2	-2.0
Alzheimer’s Disease (in mother)	1.1	1.3	1.9	-1.3	-1.4	-0.5
Medication: Metformin	1.1	1.5	4.2	2.0	0.4	-0.6
Body mass index (BMI)	1.1	4.8	10.1	-1.9	-3.2	-0.8
Past tobacco smoking	1.1	2.1	2.9	1.4	1.7	1.2
Medication: Allopurinol	1.1	1.4	2.9	-1.7	-1.1	0.4
Suffer from ‘nerves’	1.1	1.8	2.7	-1.0	-1.3	-1.7
Myopia	1.1	1.5	1.8	1.2	1.3	1.2
Vitamin and mineral supplements	1.0	1.3	2.4	-0.8	-0.9	-1.6
Falls in the last year	1.0	1.3	2.3	-1.5	-1.3	0.1
Impedance of arm (left)	1.0	4.5	8.7	1.8	3.0	1.2
Length of working week for main job	1.0	1.1	2.5	-0.7	0.5	1.6
Pulse wave reflection index	1.0	1.2	2.4	-0.1	-1.1	-1.5
Age at last live birth	1.0	1.5	2.2	0.5	1.5	1.4
Mineral and other dietary supplements	1.0	1.3	3.3	-0.4	-0.8	-1.8
Alzheimer’s Disease (including proxy)	0.9	1.3	2.3	-1.5	-0.8	1.0
Medication: Simvastatin	0.9	1.4	3.8	1.9	0.3	-0.5
Medication: Cholesterol lowering	0.9	1.4	2.2	0.9	-1.5	-1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.4	-1.0	-0.9	-1.2
Chest pain or discomfort	0.9	1.2	1.4	-1.2	-1.2	-0.9
Leg pain on walking	0.9	1.1	1.8	-1.1	-1.4	-0.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.0	1.0	1.4	0.5
Heart disease (siblings)	0.9	1.1	1.6	0.7	1.1	1.2
Alcohol drinker status: Previous	0.9	1.1	1.6	1.2	1.3	0.5
Crohns Disease (2012)	0.8	1.3	3.0	1.7	0.8	0.5
HbA1C	0.8	0.9	2.1	0.7	1.5	-0.0
HDL Cholesterol	0.8	1.4	2.1	0.9	1.4	1.1
Relative age of first facial hair	0.8	1.6	3.5	-1.9	-0.6	0.9
Medication: Co-codamol	0.8	0.9	1.6	0.1	1.1	1.3
Waist circumference	0.8	3.1	7.1	-1.5	-2.7	-0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.7	1.0	1.3	0.6
Father’s age at death	0.8	1.1	2.2	-0.1	1.0	1.5
Exposure to tobacco smoke at home	0.8	0.9	1.7	-0.9	-1.3	0.6
Emphysema/chronic bronchitis	0.8	0.9	1.8	0.8	-0.5	-1.3
Alcohol intake frequency.	0.8	1.9	2.5	1.0	1.6	-1.4
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.0	-0.0	0.9	1.4
Supplements: Vitamin C	0.8	0.9	2.2	1.5	0.8	-0.1
Medication: Aspirin	0.8	1.0	1.9	1.4	0.3	-1.1
Medication: Atorvastatin	0.8	0.9	1.4	0.3	-1.2	-1.1
Alzheimer’s Disease (in father)	0.7	0.8	2.1	0.0	0.6	1.4
Ulcerative Colitis (UC)	0.7	1.2	1.7	0.9	-1.1	-1.3
Body Mass Index (BMI) (2010)	0.7	0.9	2.3	-0.3	-1.5	-0.6
Rheumatoid Arthritis	0.7	0.9	1.3	1.2	1.0	0.7
BMI	0.7	3.9	8.4	-1.8	-2.9	-0.4
Sensitivity / hurt feelings	0.7	1.2	2.6	-0.7	-0.8	-1.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.1	-1.1	-1.0	0.4
Severe depression (siblings)	0.7	0.8	2.0	-0.3	-0.4	-1.4
Average weekly fortified wine intake	0.7	0.8	1.4	-0.6	-1.2	-0.8
Multivitamins +/- minerals	0.7	0.9	2.0	-0.6	0.6	1.4
Fluid intelligence score	0.7	1.5	2.7	0.9	1.6	1.1
Arm fat percentage (right)	0.7	2.7	6.1	-1.3	-2.5	-0.6
Worrier / anxious feelings	0.7	1.3	1.6	-0.9	-1.3	-1.2
Medication: Lansoprazole	0.7	0.8	1.8	1.3	0.6	0.3
Overall health rating	0.7	1.4	3.6	-0.8	-1.9	-0.2
Arm fat percentage (left)	0.7	2.8	6.3	-1.4	-2.5	-0.5
Medication: Bendroflumethiazide	0.7	1.0	1.7	1.3	1.1	0.4
Schizophrenia (2018)	0.6	1.2	2.0	1.4	1.1	0.6
Irritable Bowel Disease (IBD)	0.6	1.5	2.2	0.8	-1.3	-1.5
Blood Platelet Count	0.6	7.1	18.8	-1.6	0.1	4.3
Systolic Blood Pressure	0.6	3.1	4.8	2.2	1.9	-1.0
Allergy or Eczema	0.6	1.6	3.4	-0.0	1.2	1.9
Lung FVC	0.6	3.2	8.5	-2.9	-0.9	-0.4
Hand grip strength (left)	0.6	1.6	3.8	0.4	1.9	0.8
Systolic blood pressure, automated reading	0.6	1.7	2.7	1.6	1.6	0.0
Qualifications: CSEs or equivalent	0.6	0.7	1.4	-0.6	-1.2	-0.7
Medication: Atenolol	0.6	0.8	1.9	1.4	-0.4	-0.6
Hair/balding pattern: Pattern 2	0.6	0.8	1.1	1.0	0.6	1.1
Gout (self-reported)	0.6	0.8	1.8	-1.3	-0.6	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.6	-0.7	-1.2	-0.5
Worry too long after embarrassment	0.6	1.0	2.2	-0.8	-0.3	-1.5
Medication for pain relief, constipation, heartburn	0.6	1.0	1.4	1.2	1.1	0.7
Medication: Seretide 50 evohaler	0.6	0.7	2.1	0.2	-0.3	-1.4
Medication: Aspirin	0.6	0.8	1.7	0.7	-0.2	-1.3
Illnesses of father: Heart disease	0.6	0.8	1.3	0.8	-0.6	-1.2
Diabetes diagnosed by doctor	0.6	1.0	2.8	1.7	0.3	-0.3
Commuting to job workplace: Walk	0.6	0.7	0.8	0.9	0.8	-0.7
Osteoporosis (self-reported)	0.6	0.8	1.8	1.4	0.6	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.8	1.3	0.1	1.0	1.1
Fractured/broken bones in last 5 years	0.6	0.8	2.4	-1.5	0.0	0.3
Crohns Disease (2017)	0.5	1.1	1.8	0.8	-0.9	-1.4
Ovarian Cancer	0.5	0.6	1.5	-0.3	0.6	1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.8	2.5	1.6	-0.1	0.2
Angina	0.5	0.7	1.5	1.2	0.4	-0.6
Pack years adult smoking proportion	0.5	0.7	1.0	-1.0	-0.7	0.8
Taking other prescription medications	0.5	0.7	1.9	-0.3	-0.5	1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.4	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.6	1.6	0.5	-0.6
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.2	-0.0	1.0	1.5
Qualifications: None of the above	0.5	1.0	2.1	-0.3	-1.4	-0.9
Alcohol intake versus 10 years previously	0.5	0.7	2.0	0.3	-0.2	-1.4
Arm fat mass (right)	0.5	2.0	4.3	-1.3	-2.1	0.4
Qualifications: College or University degree	0.5	1.7	3.9	0.8	2.0	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-0.2	-0.7	-1.1
Qualifications: nursing, teaching	0.5	0.8	2.0	0.7	1.4	0.3
Breast cancer (self-reported)	0.5	0.6	0.7	0.9	0.6	0.8
Arm fat mass (left)	0.5	2.0	4.1	-1.3	-2.0	0.5
Medication: Blood pressure	0.5	0.9	2.3	-0.1	-0.6	-1.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.8	-0.4	-1.1
High cholesterol (Self-reported)	0.5	0.9	1.6	0.9	-1.2	-0.6
Commuting to job workplace: Cycle	0.5	0.7	1.4	-1.2	-0.1	0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	1.7	1.3	0.9	0.5
Coronary Artery Disease (CAD)	0.4	0.5	0.6	0.8	0.7	0.7
Primary Biliary Cirrhosis	0.4	0.5	1.2	1.1	0.6	-0.1
Blood Red Count	0.4	3.4	5.8	-2.4	-2.1	0.5
Heel T-Score	0.4	3.6	7.5	-2.7	-1.7	-0.6
Hand grip strength (right)	0.4	1.2	1.9	-0.3	1.4	1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	-0.6	-0.7	-0.7
Diabetes (self-reported)	0.4	0.6	1.5	1.2	-0.2	-0.5
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.7	0.7	1.3	-0.4
Blood clot in the leg (DVT)	0.4	0.5	0.6	-0.7	-0.7	-0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.7	-0.9	0.8	0.8
Comparative body size at age 10	0.4	1.1	1.5	-1.2	-1.2	0.5
Medication: Blood pressure	0.4	0.7	1.6	1.3	0.6	0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.1	-0.7	0.1
Medication: Paracetamol	0.4	0.7	1.1	-0.9	-1.1	0.1
Age started oral contraceptive pill	0.4	0.5	1.1	0.4	1.1	0.2
Mean Putamen Volume	0.3	0.3	0.5	-0.7	0.3	-0.5
Fasting Glucose	0.3	0.3	0.7	0.4	0.9	0.4
Hypothyroidism (self reported)	0.3	0.8	1.1	-1.0	-0.6	-1.0
Hearing difficulty/problems: Yes	0.3	0.4	1.3	1.1	0.2	-0.0
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.4	-0.2	-0.9
Supplements: Zinc	0.3	0.4	0.8	0.5	0.0	-0.9
Relative age voice broke	0.3	0.5	0.7	-0.8	-0.7	0.5
Serious illness, injury or assault to yourself	0.3	0.4	1.0	0.5	-0.1	1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.9	-0.1	0.6
Hearing difficulty/problems with background noise	0.3	0.6	1.3	0.6	-0.2	-1.1
Had menopause	0.3	0.3	0.4	-0.5	-0.5	-0.7
Heart attack	0.3	0.4	0.9	-0.5	-0.9	-0.3
Asthma	0.3	0.6	1.3	-0.3	-1.1	-0.6
Lung cancer (father)	0.3	0.3	1.0	-0.1	-0.0	-1.0
Loud music exposure frequency	0.3	0.3	0.8	0.5	0.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.5	0.7	0.7
Leg fat percentage (right)	0.3	1.2	3.4	-0.3	-1.8	-0.2
Number of children fathered	0.3	0.4	0.7	-0.3	0.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	0.3	-1.0	-0.2
Angina (self-reported)	0.3	0.4	1.1	1.0	0.3	-0.4
Medication: Ibuprofen	0.3	0.3	0.3	-0.5	-0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	0.7	-0.4	-0.6
Leg fat mass (right)	0.3	1.1	2.3	-0.6	-1.5	0.8
Arm predicted mass (right)	0.3	1.4	3.8	-0.6	0.2	2.0
Pulse rate, automated reading	0.3	1.0	1.2	-0.8	-1.1	1.1
Knee pain experienced in last month	0.3	0.5	0.8	-0.6	-0.9	-0.5
Smoking status: Previous	0.3	0.4	0.8	-0.7	-0.9	-0.1
Ever had bowel cancer screening	0.3	0.3	1.0	-0.1	0.1	1.0
Medication for cholesterol	0.3	0.4	0.8	-0.7	0.2	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.3	0.6	-0.6
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.4	0.1	1.0
Leg fat percentage (left)	0.3	1.1	3.2	-0.4	-1.8	-0.2
Arm fat-free mass (left)	0.3	1.4	3.8	-0.4	0.3	2.0
Number of operations (self-reported)	0.3	0.4	0.9	-0.5	-0.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.8	-0.5	-0.6
Leg fat mass (left)	0.3	1.1	2.2	-0.6	-1.5	0.8
Breast Cancer	0.2	0.5	1.1	-1.1	-0.2	-0.5
Schizophrenia (2014)	0.2	0.4	0.6	0.7	0.7	0.4
Blood Eosinophil Count	0.2	1.8	3.1	-1.8	-1.0	1.0
Lung FEV1/FVC ratio	0.2	1.2	1.5	1.2	0.9	1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	0.4	-0.4	-0.5
Diabetes (father)	0.2	0.2	0.3	-0.1	-0.5	-0.5
Leg fat-free mass (left)	0.2	1.2	3.0	-0.8	0.1	1.7
Age when periods started (menarche)	0.2	0.5	0.9	0.9	0.6	-0.5
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.4	-0.7	-0.5
Leg predicted mass (left)	0.2	1.3	3.2	-0.8	-0.0	1.8
Trunk fat mass	0.2	0.8	2.1	-0.2	-0.4	1.5
Number of incorrect matches in round	0.2	0.3	0.5	-0.5	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	1.0	0.2	-0.6
Mouth/teeth dental problems	0.2	0.4	0.5	0.6	0.7	0.5
Pain all over the body in last month	0.2	0.2	0.4	0.6	0.3	0.4
Medication: Ramipril	0.2	0.3	0.7	0.1	0.2	0.8
Weight	0.2	1.1	2.7	-0.7	-0.5	1.6
Trunk fat-free mass	0.2	1.4	3.2	-0.7	0.6	1.8
Noisy workplace	0.2	0.2	0.5	-0.4	0.2	-0.7
Trunk predicted mass	0.2	1.3	3.1	-0.6	0.7	1.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.5	-0.1	-0.1	-1.2
High blood pressure (siblings)	0.2	0.3	0.7	-0.8	-0.3	-0.0
Arm fat-free mass (right)	0.2	1.1	2.9	-0.6	0.1	1.7
Whole body fat mass	0.2	0.9	1.4	-0.6	-1.2	1.0
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.5	0.6	0.3
Whole body fat-free mass	0.2	1.3	3.2	-0.7	0.3	1.8
Leg fat-free mass (right)	0.2	1.1	2.7	-0.8	0.1	1.6
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.2	-0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	-0.8	-0.3	-0.6
Whole body water mass	0.2	1.2	3.0	-0.7	0.3	1.7
Leg predicted mass (right)	0.2	1.1	2.8	-0.8	0.1	1.7
Mother’s age at death	0.2	0.2	0.4	-0.2	-0.5	-0.6
Financial situation satisfaction	0.2	0.2	0.5	0.7	-0.0	-0.4
Basal metabolic rate	0.2	1.3	3.2	-0.8	0.1	1.8
Risk taking	0.2	0.2	0.4	-0.3	-0.4	-0.7
Diastolic blood pressure, automated reading	0.2	0.7	2.0	-0.0	-0.3	1.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.1	0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.4	-0.8	-0.1
Pack years of smoking	0.2	0.3	0.5	-0.5	-0.2	0.7
Arm predicted mass (left)	0.2	1.0	2.8	-0.5	0.1	1.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.2	0.6	-0.2
Reaction Time	0.1	0.2	0.5	-0.0	-0.7	-0.0
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	0.0	0.4
Ulcerative Colitis	0.1	0.1	0.3	0.6	-0.3	-0.0
Blood White Count	0.1	1.1	1.8	-1.0	-0.6	1.3
Cardiovascular Disease	0.1	0.4	0.6	0.8	-0.8	-0.1
Chronotype (morning person)	0.1	0.2	0.7	-0.2	0.8	0.3
Tanning	0.1	0.8	1.3	1.0	1.2	0.4
Number of treatments/medications taken	0.1	0.1	0.2	0.5	-0.1	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.4	-0.1	-0.2
Diabetes (mother)	0.1	0.1	0.2	0.3	-0.5	0.0
Trunk fat percentage	0.1	0.4	1.0	0.0	-0.4	1.0
High blood pressure (mother)	0.1	0.1	0.3	0.1	0.6	-0.0
Alcohol usually taken with meals	0.1	0.2	0.3	0.3	0.5	-0.5
Had other major operations	0.1	0.1	0.2	0.5	0.2	-0.2
Financial difficulties in last 2 years	0.1	0.1	0.2	0.4	0.1	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.9	0.0	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.2	-0.6	0.1
Breastfed as a baby	0.1	0.2	0.5	-0.1	-0.1	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.1	0.7	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	0.1	-0.0	-0.6
Body fat percentage	0.1	0.5	1.4	-0.3	-1.2	0.4
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.3	-0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.6	0.0	-0.2
Medication: Omeprazole	0.1	0.2	0.3	-0.3	-0.5	-0.3
Mean time to correctly identify matches	0.1	0.2	0.5	0.7	0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.0	-0.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.5	0.2	0.4
Hypertension (Self-reported)	0.1	0.2	0.6	0.8	0.1	0.3
Average weekly red wine intake	0.1	0.2	0.4	0.3	0.7	0.0
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	-0.2	-0.5
Back pain experienced in last month	0.1	0.2	0.3	0.5	-0.2	-0.5
Asthma (self-reported)	0.1	0.3	0.7	-0.2	-0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	0.0	0.5
Medication: Lisinopril	0.1	0.1	0.2	0.4	-0.1	0.1
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.1	-0.6	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.3	0.5	0.8
Cholesterol lowering medication	0.1	0.2	0.5	0.3	-0.7	-0.3
Bipolar Disorder (2018)	0.0	0.0	0.1	0.3	0.2	0.1
Respiratory disease	0.0	0.1	0.2	-0.2	-0.4	-0.2
Hair Pigment	0.0	0.3	0.6	0.8	0.4	-0.0
High blood pressure	0.0	0.0	0.0	0.2	-0.2	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.4	0.1	0.0
Allergy	0.0	0.1	0.1	0.3	-0.0	-0.4
Illnesses of siblings	0.0	0.0	0.1	-0.0	-0.1	-0.3
Hip circumference	0.0	0.1	0.1	0.2	0.0	0.3
Illnesses of mother	0.0	0.0	0.1	0.3	0.1	-0.0
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.2	0.2	0.1
Alcohol drinker status: Never	0.0	0.0	0.1	0.3	0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	0.3	0.2	0.3

Hub : Genes

TRMT10A

Models

Trait associations