Hub : Genes

TRPM4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1950 0.0590 1.6e-05 0.027 NA 0.064 NA 0.063 2.4e-03 NA 6.0e-06 NA 7.1e-06
2 GTEx Artery Tibial 0.1556 0.0533 7.4e-04 0.079 NA 0.056 NA 0.050 8.8e-07 NA 3.5e-05 NA 8.5e-05
3 GTEx Breast Mammary Tissue 0.1890 0.0820 5.7e-03 -0.005 NA 0.012 NA -0.003 9.2e-01 NA 7.2e-02 NA 5.4e-01
4 GTEx Breast Mammary Tissue (Female) 0.1621 0.0932 5.2e-02 -0.007 NA -0.009 NA -0.004 5.7e-01 NA 8.3e-01 NA 4.5e-01
5 GTEx Cells Transformed fibroblasts 0.1940 0.0630 1.1e-03 0.017 NA 0.064 NA 0.031 1.9e-02 NA 1.6e-05 NA 2.2e-03
6 GTEx Nerve Tibial 0.3041 0.0728 1.9e-04 0.123 NA 0.100 NA 0.099 5.2e-09 NA 1.5e-07 NA 1.7e-07
7 GTEx Spleen 0.5560 0.1090 1.5e-05 0.279 NA 0.212 NA 0.269 7.6e-08 NA 3.9e-06 NA 1.4e-07
8 METSIM Adipose 0.1296 0.0371 1.5e-06 0.045 0.035 0.057 0.047 0.046 2.1e-07 4.5e-06 6.5e-09 1.4e-07 1.9e-07
9 YFS Blood 0.0909 0.0190 1.2e-15 0.060 0.069 0.069 0.072 0.071 7.7e-19 1.0e-21 1.2e-21 1.6e-22 2.4e-22
10 TCGA Breast Invasive Carcinoma 0.0354 0.0154 8.6e-04 0.005 0.008 0.005 NA 0.001 2.3e-02 7.2e-03 2.6e-02 NA 1.8e-01
11 TCGA Brain Lower Grade Glioma 0.0517 0.0216 2.8e-04 0.026 0.031 0.027 NA 0.029 5.5e-04 1.8e-04 4.2e-04 NA 2.9e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.7 1.1 5.2 0.2 -2.3 0.0 0.8 0.9 -0.9 0.3 -0.7 -1.1 1.7 0.1
Bipolar Disorder or Schizophrenia 0.5 1.2 4.8 1.9 -0.7 0.0 -1.0 2.2 0.7 0.7 0.4 -0.7 1.4 0.0
Depressed Affect (Nagel 2018) 1.0 2.1 9.6 -1.0 -1.5 0.0 -2.0 -1.1 -0.5 -3.1 0.5 -1.4 -0.2 1.6
Depression (Nagel 2018) 1.0 1.5 4.7 1.9 0.7 0.0 0.6 0.2 0.5 -1.8 1.6 -1.0 0.0 2.2
Intelligence (Savage-Jansen 2018) 0.5 1.5 6.7 -2.6 -1.0 0.0 2.2 -1.3 -0.2 0.3 0.9 0.4 -0.9 -0.1
Neuroticism (Nagel 2018) 0.6 1.3 7.5 -0.3 -1.8 0.0 -1.0 -0.8 -0.2 -2.7 0.3 -0.5 -1.0 0.8
Schizophrenia (2018) 0.8 1.6 4.9 2.2 0.7 0.0 -2.0 2.0 1.6 0.7 1.1 0.1 0.3 -0.0
Schizophrenia vs Biploar Disorder 0.3 0.4 2.2 0.0 0.0 0.0 -1.3 0.0 1.5 -0.1 0.0 0.7 -0.7 -0.1
Worry (Nagel 2018) 0.5 1.1 5.1 -0.5 -1.4 0.0 -1.4 -1.0 -0.5 -2.2 -0.1 -0.3 -1.3 0.4
Alzheimer’s Disease (in mother) 0.3 0.3 1.1 -0.8 -1.1 0.0 0.9 -0.6 -0.2 -0.3 -0.0 -0.2 -0.1 -0.5
Alzheimer’s Disease (in father) 1.4 1.5 6.7 -0.2 0.4 0.0 0.1 -0.5 -0.8 -1.0 -1.7 1.1 -2.6 -2.0
Alzheimer’s Disease (including proxy) 0.5 0.8 2.0 -0.6 -0.8 0.0 0.8 -0.4 -0.9 -1.2 -1.1 -0.1 -1.4 -1.2
Crohns Disease (2017) 1.0 2.2 13.1 -1.3 -3.6 0.0 -2.0 -0.0 -1.2 -1.3 1.3 -0.0 -0.8 0.5
Irritable Bowel Disease (IBD) 1.0 2.3 10.9 -1.6 -3.3 0.0 -2.1 -1.0 -1.6 -1.1 -0.3 0.8 -1.5 -0.3
Ulcerative Colitis (UC) 0.9 1.7 3.6 -1.5 -1.9 0.0 -1.4 -1.3 -1.6 -1.1 -1.8 0.6 -1.3 -0.4
Major Depression (MDD) 0.6 0.8 3.4 0.8 0.4 0.0 1.6 0.0 1.8 0.3 0.0 -0.9 -0.1 0.7
Reaction Time 0.8 1.6 9.0 0.1 -0.7 0.0 0.8 -0.9 0.2 -3.0 1.1 -1.2 -1.9 -0.0
Verbal and Numeric Reasoning (VNR) 0.3 0.7 3.6 -1.0 0.2 0.0 1.9 -0.6 0.2 0.8 1.0 -0.1 0.4 0.7
Breast Cancer 0.5 1.2 5.2 -0.2 -0.5 0.0 -0.3 -1.2 -0.8 -0.5 -1.5 0.8 -1.6 -2.3
Ovarian Cancer 0.7 0.9 2.3 -0.3 0.1 0.0 0.0 -1.2 -1.5 -0.1 -0.6 -1.3 1.4 1.5
Prostate Cancer 2.4 3.4 7.6 2.2 1.4 0.0 -0.1 2.8 2.7 -0.6 2.7 -1.3 1.1 2.3
Age at First Birth 0.9 1.3 5.0 -0.2 -1.1 0.0 -2.2 0.4 -1.0 -1.5 1.0 -1.1 0.7 1.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 3.4 1.1 0.1 0.0 1.9 -1.0 -0.1 -1.0 -0.6 -0.2 -0.6 -0.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.1 1.7 8.0 -0.2 -2.8 0.0 -2.3 0.0 -1.3 -0.6 0.8 -1.4 0.4 0.9
Mean Putamen Volume 2.2 2.5 9.5 -1.1 0.3 0.0 -0.8 -0.0 -0.7 2.0 -1.4 3.1 -1.2 -2.9
Fasting Glucose 0.8 1.0 2.3 0.5 1.3 0.0 1.1 0.1 1.5 1.2 1.3 -0.6 1.3 0.6
HbA1C 0.4 0.4 2.2 -0.5 -0.5 0.0 -1.5 -0.8 -0.4 -0.8 -0.1 -0.4 0.5 0.5
HDL Cholesterol 0.4 0.6 2.7 -1.4 -0.6 0.0 -0.4 -0.3 -1.6 0.6 -1.1 -0.1 0.5 -0.2
LDL Cholesterol 1.1 1.8 7.1 -1.4 -2.7 0.0 -1.6 -1.2 -1.1 0.6 0.4 1.6 -1.1 -1.0
Lupus 1.2 1.8 6.1 1.8 1.4 0.0 2.5 -0.5 -0.3 -1.6 -1.7 -0.8 -1.0 0.8
Neuroticism (2016) 1.0 1.4 4.6 0.8 0.0 0.0 -1.0 0.6 0.4 -1.0 1.9 -1.7 1.3 2.1
Primary Biliary Cirrhosis 0.8 1.1 3.3 1.6 0.6 0.0 -1.2 0.2 0.7 1.2 1.0 1.8 -1.1 -0.8
Rheumatoid Arthritis 0.8 1.0 3.5 0.4 -0.6 0.0 0.9 -0.4 -0.8 -1.9 -0.7 -1.5 0.4 1.8
Schizophrenia (2014) 1.0 2.2 5.3 2.2 1.0 0.0 -2.1 2.3 2.1 1.3 1.2 0.6 0.5 -0.8
Triglycerides 0.3 0.5 2.8 -0.6 -1.7 0.0 -0.4 -0.5 -0.1 -0.3 0.9 0.9 0.0 -0.6
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.8 1.2 3.3 -1.3 -1.3 0.0 -1.5 -0.4 -1.8 -0.8 -1.8 -0.4 -0.3 0.6
Blood Eosinophil Count 0.5 4.1 24.4 1.9 -0.8 0.0 1.3 0.0 0.5 -1.9 4.9 -1.8 0.9 2.7
Blood Platelet Count 0.5 5.9 31.8 -3.2 -5.6 0.0 -0.9 -0.1 -1.2 -2.4 3.7 -0.4 -0.8 0.6
Blood Red Count 0.3 2.4 16.6 -4.1 -1.4 0.0 1.3 -1.7 0.4 -1.0 0.8 1.2 0.1 -0.4
Blood White Count 0.2 1.6 4.4 -2.1 -1.8 0.0 -0.2 -1.5 0.5 0.9 2.0 0.1 1.2 0.9
Heel T-Score 0.2 1.8 6.7 -0.4 2.0 0.0 1.4 1.1 0.2 2.6 -1.5 -0.5 1.3 -1.0
BMI 0.4 2.4 10.2 0.3 0.1 0.0 2.6 -1.7 -0.9 -3.2 -1.8 -1.4 -1.0 0.0
Height 0.5 9.6 23.4 -3.5 -1.2 0.0 -0.8 -3.2 -3.3 -4.8 1.9 -4.7 2.4 3.8
Waist Hip Ratio (WHR) 0.2 0.9 3.0 0.4 -1.2 0.0 -0.7 1.3 0.7 0.8 1.1 0.3 1.7 0.6
Systolic Blood Pressure 0.6 2.8 10.2 -0.4 -2.9 0.0 3.2 -1.6 -0.2 0.6 -1.1 0.9 -1.2 -2.2
Smoking Status 0.3 0.8 2.6 0.8 0.7 0.0 1.5 -0.0 1.0 1.6 0.3 0.6 0.8 0.6
Allergy or Eczema 0.3 0.9 2.9 -1.7 -0.9 0.0 -0.2 -0.6 -0.3 -1.4 0.1 -1.7 -0.1 0.6
Cardiovascular Disease 0.6 2.1 17.2 0.1 -4.1 0.0 0.6 -0.3 -1.2 0.2 1.2 0.4 -0.2 -1.7
Hypothyroidism (self reported) 0.5 1.2 5.7 -1.3 -2.4 0.0 -1.1 -0.9 -0.4 -0.5 0.8 -1.3 -0.8 -0.8
Respiratory disease 0.2 0.4 1.8 0.4 1.3 0.0 -0.1 -0.5 -0.1 -0.4 -0.3 0.5 -1.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 4.5 0.3 0.3 0.0 1.3 -0.8 -0.4 2.1 0.7 0.7 0.6 -0.3
Lung FEV1/FVC ratio 0.4 2.2 12.3 0.3 2.9 0.0 0.6 -0.5 -0.0 1.1 -3.5 0.4 0.5 -1.2
Lung FVC 0.7 3.7 14.0 -1.9 -3.2 0.0 -1.9 -1.0 -1.7 -3.7 -0.4 -0.6 -2.1 0.4
Neuroticism 0.9 2.3 10.8 -0.4 -2.1 0.0 -1.4 -1.7 -0.1 -3.3 1.0 -1.0 -1.0 1.4
Chronotype (morning person) 1.2 2.8 11.8 -0.1 -0.9 0.0 -1.1 -2.6 -0.8 -3.4 -1.6 -0.4 -2.6 0.3
Hair Pigment 0.0 1.1 3.7 1.8 1.9 0.0 0.4 0.5 0.9 0.9 -1.4 0.7 -0.0 -1.0
Tanning 0.2 2.1 8.0 0.7 -0.4 0.0 -0.5 1.7 -0.5 -0.4 0.6 -2.3 2.8 2.3
Hand grip strength (left) 0.3 0.7 2.6 -0.3 -0.4 0.0 1.6 -1.4 -1.3 -0.5 -0.7 -0.2 -0.3 -0.4
Number of treatments/medications taken 1.0 1.8 9.1 -0.3 -3.0 0.0 -0.0 -2.2 -1.6 -1.1 0.1 -0.5 -1.3 -0.5
Average weekly spirits intake 0.6 0.7 2.8 -0.7 0.6 0.0 -0.5 -1.3 -0.2 -1.4 -1.7 -0.8 0.2 -0.1
Sensitivity / hurt feelings 1.0 1.7 8.1 -0.3 -1.5 0.0 -0.3 -0.4 -0.2 -2.9 1.8 -0.5 -1.7 1.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.7 1.0 0.9 0.0 -0.3 -0.4 0.9 -0.4 1.6 -0.1 0.1 1.4
Hearing difficulty/problems: Yes 0.5 0.7 4.5 -0.1 -0.6 0.0 0.3 -0.8 0.2 -1.0 0.5 0.9 -2.1 -0.3
Relative age of first facial hair 0.6 1.3 8.0 0.5 -0.1 0.0 -0.4 0.3 -1.3 -2.8 0.6 -0.6 -0.5 1.8
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 4.3 0.2 -1.3 0.0 -0.1 0.1 -0.9 -1.7 -0.5 -2.1 0.6 2.0
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.5 0.9 -0.9 0.0 0.5 0.4 0.4 -1.2 0.7 -1.0 0.1 1.1
Ever had hysterectomy (womb removed) 2.4 2.8 8.2 -2.1 -1.8 0.0 -1.3 -2.9 -2.8 -0.7 -2.1 -0.4 -0.5 0.0
Systolic blood pressure, automated reading 0.6 1.8 4.1 0.5 -2.0 0.0 1.9 -1.9 -0.7 0.5 -1.5 0.5 -0.9 -2.0
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.5 1.8 1.9 0.0 -0.3 -0.1 1.9 0.7 1.3 1.4 -1.4 -1.3
Angina 0.4 0.6 2.0 0.4 0.2 0.0 -0.1 -0.9 1.4 -1.0 1.1 -0.6 -0.4 0.8
Medication for hormone replacement therapy 0.3 0.3 1.8 0.1 -0.2 0.0 1.3 0.1 0.4 1.0 0.6 0.0 -0.4 -0.1
Vitamin and mineral supplements 0.9 1.2 4.3 -1.6 -1.2 0.0 -0.6 -2.1 -1.3 -0.0 -1.2 0.5 -0.2 -1.0
Supplements: Zinc 1.5 1.6 4.4 2.0 1.7 0.0 0.2 0.4 1.6 0.3 2.1 -0.9 1.3 1.2
Medication: Co-codamol 0.3 0.4 1.3 0.6 0.9 0.0 -1.1 -0.2 -0.0 -0.7 -0.1 -0.6 0.3 0.8
Medication: Metformin 1.6 2.3 6.8 2.1 2.0 0.0 1.4 1.8 1.1 2.6 1.1 1.0 0.4 -1.0
Diabetes (father) 1.6 2.0 5.5 0.7 2.4 0.0 -0.5 1.4 2.3 -0.1 0.9 -1.4 1.3 2.0
Diabetes (mother) 0.3 0.4 1.3 -0.7 1.0 0.0 -0.5 -0.0 0.5 0.6 -0.1 -0.1 1.1 0.2
Severe depression (siblings) 1.2 1.4 5.6 -1.1 -2.4 0.0 -0.4 -1.7 -0.4 -0.1 -0.3 0.8 -0.8 -1.9
Pack years adult smoking proportion 1.5 2.3 6.4 -1.2 -2.1 0.0 -1.3 0.3 -1.1 -0.6 -0.1 -2.5 2.5 1.7
Impedance of leg (right) 0.6 2.7 10.0 1.0 1.5 0.0 -1.8 3.2 1.3 2.8 1.1 0.7 1.3 0.2
Leg fat-free mass (left) 0.7 3.9 15.2 -1.4 -0.9 0.0 2.0 -3.5 -2.0 -3.9 0.1 -1.8 -0.2 1.0
Trunk fat percentage 0.3 1.0 6.2 0.5 -0.2 0.0 0.3 -0.6 -0.5 -2.5 -0.8 -1.8 -0.0 0.2
Hand grip strength (right) 0.3 0.7 2.6 -0.3 -0.4 0.0 1.6 -1.2 -1.5 -0.4 -0.6 -0.0 -0.2 -0.8
Townsend deprivation index at recruitment 0.5 0.7 2.0 0.5 0.0 0.0 -0.9 -0.7 1.0 1.2 0.3 1.1 -0.8 -1.4
Current tobacco smoking 1.1 1.9 7.5 0.7 1.7 0.0 0.2 -0.1 1.2 1.6 0.4 -1.0 2.7 2.1
Average weekly fortified wine intake 0.9 1.0 2.3 1.4 1.0 0.0 1.1 0.5 1.5 0.8 -0.2 1.2 -0.8 -1.3
Maternal smoking around birth 1.7 2.4 8.8 -0.3 -3.0 0.0 -0.5 -1.7 -0.8 -2.6 -0.2 -2.3 0.3 1.4
Fed-up feelings 0.4 0.8 4.3 -0.3 -1.0 0.0 -1.3 -2.1 0.2 -0.8 -0.4 -0.2 -0.6 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 7.0 1.9 0.7 0.0 -0.0 -0.9 1.4 -1.1 2.6 -0.9 -0.2 1.7
Relative age voice broke 1.0 1.6 8.6 -1.0 -1.2 0.0 0.1 -0.9 -1.6 -2.9 -0.7 -0.0 -1.4 0.2
Taking other prescription medications 1.5 2.2 6.9 -0.1 -2.6 0.0 1.4 -2.2 -2.6 -0.8 -1.1 -0.6 -1.3 -0.2
Age when periods started (menarche) 0.4 0.9 3.2 0.2 -0.5 0.0 1.8 -0.8 -0.8 -1.1 1.2 -0.4 -1.0 1.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 -0.1 -0.7 0.0 0.4 -0.6 -0.5 -0.7 0.8 -0.6 -0.9 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 10.3 0.1 0.1 0.0 3.2 0.3 0.1 0.4 -0.7 -0.3 -0.3 -0.2
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 3.9 0.5 -1.2 0.0 -0.2 -0.4 -0.2 -1.7 0.5 -2.0 0.5 1.6
Qualifications: CSEs or equivalent 0.2 0.3 1.0 0.5 0.4 0.0 0.3 0.2 -0.7 0.5 0.0 -0.2 1.0 0.9
Serious illness, injury or assault to yourself 0.2 0.3 1.7 0.2 -1.0 0.0 -0.3 -1.3 -0.5 -0.2 0.0 -0.2 -0.5 -0.1
High blood pressure 0.3 0.8 3.1 1.5 -1.8 0.0 1.2 -0.2 -0.5 -0.1 0.1 -1.0 0.4 -0.8
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.8 -1.1 -0.6 0.0 0.4 -0.1 -0.7 -1.1 -0.2 -1.3 -0.5 0.8
Multivitamins +/- minerals 0.8 1.1 3.4 1.4 1.3 0.0 -0.3 1.6 1.9 0.8 0.9 0.4 -0.4 -0.4
Stomach or abdominal pain in last month 0.8 1.1 4.3 -0.6 -1.1 0.0 0.3 0.6 -0.6 -1.1 0.1 -2.1 1.0 1.7
Supplements: Glucosamine 1.0 1.3 5.2 2.3 1.4 0.0 1.0 1.0 1.2 0.1 1.6 0.1 -0.9 0.0
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.7 0.4 0.7 0.0 1.9 1.4 0.1 0.3 0.2 -1.5 1.3 1.9
Medication: Atenolol 1.0 1.3 5.4 0.1 -1.3 0.0 -0.8 -1.6 -0.3 -2.3 0.9 -0.4 -1.6 -0.1
Medication: Levothyroxine sodium 1.0 1.6 4.4 -0.6 -1.9 0.0 0.2 -1.6 -0.5 -2.1 0.7 -2.1 -1.2 0.6
Sitting height 0.4 2.7 8.7 -1.9 -1.0 0.0 -0.6 -3.0 -2.1 -1.9 1.7 -2.0 0.5 1.0
Chronic bronchitis/emphysema (father) 0.5 0.6 1.9 0.0 -1.2 0.0 0.4 1.4 -0.7 -1.0 -0.2 -1.0 -0.5 -0.1
High blood pressure (mother) 0.3 0.4 1.0 -0.0 -0.8 0.0 1.0 -0.3 0.8 -0.4 0.4 -0.7 -0.7 -1.0
Body mass index (BMI) 0.5 1.9 7.2 1.6 0.7 0.0 2.5 -1.0 0.4 -2.7 -0.5 -1.8 -0.2 0.4
Impedance of leg (left) 0.5 2.5 9.7 0.6 1.3 0.0 -1.6 3.1 1.1 2.8 1.0 0.3 1.5 0.6
Leg predicted mass (left) 0.8 4.0 15.4 -1.4 -1.0 0.0 2.1 -3.5 -2.0 -3.9 0.0 -1.9 -0.2 1.0
Trunk fat mass 0.4 1.8 9.3 0.2 -0.2 0.0 1.2 -1.5 -0.9 -3.1 -0.5 -2.3 0.2 0.7
Waist circumference 0.4 1.4 5.1 0.8 0.5 0.0 1.4 -0.8 0.1 -2.2 0.3 -2.1 0.8 1.1
Number of incorrect matches in round 0.6 1.0 7.4 0.0 0.2 0.0 -2.7 0.6 0.1 1.4 -0.6 0.6 0.8 -0.7
Past tobacco smoking 0.4 0.7 2.6 0.3 0.2 0.0 -1.6 0.5 -0.1 0.3 -0.3 -1.2 1.6 0.5
Alcohol usually taken with meals 0.4 0.6 2.0 -0.4 -1.4 0.0 0.1 0.7 -0.5 -0.8 1.4 -0.1 -1.2 0.4
Nervous feelings 0.2 0.4 1.9 -0.1 -1.3 0.0 -0.4 -0.5 -0.4 -0.8 0.1 0.1 -1.4 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 3.4 -0.4 0.2 0.0 0.9 -1.8 0.4 -0.1 1.1 1.6 -1.8 -1.1
Hearing difficulty/problems with background noise 1.0 1.5 9.9 0.1 -1.4 0.0 0.1 -0.2 0.4 -3.1 0.3 -0.9 -1.8 0.8
Hair/balding pattern: Pattern 2 0.4 0.6 2.1 0.6 0.8 0.0 -1.0 0.7 1.0 -0.3 -0.4 -0.7 0.3 1.4
Had menopause 0.3 0.3 1.0 0.9 -1.0 0.0 0.2 -0.0 -0.5 -1.0 0.4 -0.4 -0.3 0.6
Had other major operations 0.3 0.4 2.1 0.6 -1.4 0.0 -0.7 0.3 -0.5 -0.7 -0.4 -0.2 -0.1 0.5
Forced vital capacity (FVC) 0.6 2.3 7.2 -2.7 -1.8 0.0 -0.5 -1.4 -2.4 -2.4 0.4 -0.6 -0.2 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 7.5 -0.4 -0.2 0.0 2.7 -0.6 -0.6 0.2 -1.1 0.0 -0.7 -0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 4.5 0.7 0.2 0.0 1.4 0.2 0.5 -0.5 2.1 -0.8 -0.4 0.3
Qualifications: None of the above 0.7 1.5 5.8 -1.0 -0.4 0.0 -1.5 -1.7 -1.1 -2.4 -0.9 -0.6 -1.1 0.7
Financial difficulties in last 2 years 0.3 0.3 1.7 0.9 1.3 0.0 0.6 -0.2 0.8 0.1 -0.1 0.2 0.0 0.5
Mouth/teeth dental problems 0.7 1.1 3.7 0.8 1.9 0.0 0.6 0.1 1.0 1.9 0.4 1.3 -0.3 -0.5
Heart attack 1.1 1.4 4.2 0.5 0.4 0.0 -0.3 -1.0 1.2 -1.1 1.7 -2.1 0.2 1.9
Allergy 0.3 0.7 2.6 0.6 0.2 0.0 -1.0 0.9 0.5 1.6 -0.1 0.8 1.5 -0.3
Pain all over the body in last month 0.1 0.1 0.4 -0.5 -0.0 0.0 -0.6 0.1 -0.1 0.3 -0.4 -0.3 0.3 0.2
Diabetes (self-reported) 0.6 1.0 6.5 0.9 0.7 0.0 0.1 0.1 -0.2 2.5 0.2 0.2 1.6 -0.5
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 4.0 0.4 1.0 0.0 2.0 0.7 0.4 1.7 -0.3 -0.4 1.1 0.5
Medication: Ramipril 1.7 2.2 6.1 0.9 -1.6 0.0 0.6 0.7 0.5 -1.2 2.0 -2.5 1.6 2.3
Medication: Simvastatin 1.5 2.2 7.6 -0.8 -2.8 0.0 -1.0 0.3 -1.3 -1.6 2.0 -2.0 0.8 1.5
Fluid intelligence score 0.7 1.5 5.7 0.1 0.6 0.0 2.4 1.4 1.2 0.2 2.0 -0.9 0.7 1.5
Illnesses of siblings 0.2 0.3 0.6 -0.6 -0.7 0.0 0.8 -0.6 -0.6 -0.4 0.2 0.8 -0.1 -0.8
Neuroticism score 0.5 1.1 4.3 -0.5 -1.5 0.0 -0.6 -1.7 0.0 -2.1 0.3 -0.5 -1.0 0.8
Weight 0.7 3.3 14.6 0.0 0.1 0.0 2.0 -2.4 -1.1 -3.8 0.1 -2.9 0.4 1.4
Impedance of arm (right) 0.5 2.6 7.6 -1.8 -1.2 0.0 -2.8 0.8 -1.1 2.4 -0.5 2.2 -0.2 -1.7
Arm fat percentage (right) 0.3 1.1 4.6 0.8 -0.1 0.0 1.6 -0.9 -0.3 -2.1 -1.1 -1.2 -0.5 -0.5
Trunk fat-free mass 0.8 4.3 15.4 -1.1 -0.7 0.0 2.1 -3.3 -2.0 -3.9 0.9 -2.5 0.7 1.9
Hip circumference 0.5 2.1 7.8 0.1 0.8 0.0 1.7 -1.4 -0.8 -2.8 -0.2 -2.7 0.7 1.3
Time employed in main current job 0.8 0.9 5.1 -1.2 -1.1 0.0 0.6 -0.8 -2.3 0.6 -0.6 0.3 -0.0 -0.7
Alcohol intake versus 10 years previously 0.6 0.9 4.8 1.1 2.2 0.0 0.7 0.4 0.9 -0.4 -0.6 -0.7 -0.2 1.1
Father’s age at death 0.6 0.9 2.8 -0.3 -0.3 0.0 -0.2 -0.1 -1.5 0.2 0.7 -1.7 1.5 1.2
Worrier / anxious feelings 0.4 0.7 2.7 0.4 -1.2 0.0 -1.6 0.3 0.1 -1.4 -0.3 -0.8 -0.6 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 11.0 0.9 0.2 0.0 -0.2 -0.8 1.9 0.6 3.3 -0.6 0.8 1.1
Falls in the last year 0.3 0.4 1.4 0.9 0.1 0.0 -0.2 -0.2 1.2 0.5 0.9 -0.8 0.6 0.7
Hair/balding pattern: Pattern 3 0.7 1.0 3.0 0.6 1.0 0.0 0.9 0.9 1.0 1.7 0.8 -0.1 1.7 -0.4
Number of live births 0.3 0.5 1.4 1.0 0.4 0.0 -0.7 0.2 1.0 0.1 -0.2 1.2 0.0 -1.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 5.4 -2.3 -0.8 0.0 0.0 -1.3 -2.0 -1.9 -0.4 -0.6 0.2 0.6
Pulse rate 3.1 5.3 18.4 1.6 0.4 0.0 -0.2 1.6 1.1 -2.4 3.1 -3.8 2.0 4.3
Happiness 0.3 0.4 2.4 0.5 -0.3 0.0 -0.2 -0.0 -0.1 -0.5 1.6 0.1 -0.9 0.7
Noisy workplace 0.6 0.8 3.0 -0.6 -0.6 0.0 -1.7 -0.5 -0.0 -1.0 -0.3 -1.2 0.5 1.4
Qualifications: A levels/AS levels or equivalent 1.0 2.2 7.3 -0.1 0.4 0.0 1.5 1.0 1.7 2.7 -0.1 2.2 -0.2 -2.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 2.8 0.2 -0.4 0.0 -0.5 -0.8 -0.5 0.2 0.1 1.2 -1.7 -0.6
Mouth/teeth dental problems: Dentures 1.9 3.2 11.4 -2.3 -3.4 0.0 0.7 -1.7 -2.4 -2.6 -0.3 -1.0 -0.7 0.5
Asthma 0.4 0.7 2.6 0.8 1.5 0.0 -0.0 -0.6 -0.2 -0.7 -0.4 0.8 -1.6 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.9 -0.4 -0.8 0.0 0.6 -0.6 0.3 -1.0 -0.1 -0.5 0.2 0.3
Medication: Cholesterol lowering 1.4 2.2 16.2 -0.9 -4.0 0.0 0.1 -1.2 -1.2 -1.0 1.3 -1.0 -0.2 0.2
Depression (self-reported) 0.9 1.1 5.3 0.7 0.3 0.0 -0.8 1.0 1.1 -0.4 2.3 -0.5 -1.2 1.1
Medication: Lansoprazole 0.5 0.6 2.7 0.2 -0.0 0.0 0.5 -1.6 -0.3 -0.6 -1.0 0.5 -1.1 -0.8
Prospective memory result 0.7 0.9 4.4 2.1 0.6 0.0 -1.0 0.5 0.4 -0.7 0.2 -0.7 0.6 1.4
Lung cancer (father) 0.3 0.4 1.7 0.7 0.3 0.0 -0.6 1.3 0.3 0.0 0.4 -0.5 0.9 0.1
Illnesses of mother 1.1 1.3 4.6 0.6 1.4 0.0 -2.2 1.4 0.0 1.1 -0.4 1.1 1.4 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 7.5 -2.7 -1.2 0.0 0.3 -1.3 -2.6 -1.8 -1.0 -0.5 0.3 0.4
Pulse wave Arterial Stiffness index 0.9 1.1 3.6 0.1 -0.1 0.0 -0.2 -1.4 0.9 -1.2 1.3 -1.9 0.7 1.4
Impedance of arm (left) 0.5 2.5 5.9 -2.2 -1.0 0.0 -2.4 0.6 -1.2 2.4 -1.1 2.1 -0.4 -1.7
Arm fat mass (right) 0.5 1.9 10.2 0.5 -0.2 0.0 1.8 -1.7 -0.6 -3.2 -0.6 -1.8 -0.4 0.3
Trunk predicted mass 0.8 4.4 15.4 -1.1 -0.7 0.0 2.1 -3.4 -2.0 -3.9 0.8 -2.5 0.6 1.9
Standing height 0.6 5.8 13.4 -3.5 -1.6 0.0 -0.9 -3.3 -3.7 -3.0 1.2 -2.4 1.4 2.3
Length of working week for main job 1.5 1.7 3.4 -1.7 -1.8 0.0 -1.8 -1.0 -1.8 -1.2 -1.5 -0.1 -0.8 0.1
Exposure to tobacco smoke at home 2.1 2.3 11.6 2.5 0.5 0.0 0.1 0.5 2.2 -0.1 3.4 0.6 -1.5 0.2
Breastfed as a baby 2.5 3.1 7.0 2.6 1.7 0.0 0.1 2.1 2.6 2.1 2.5 0.6 1.6 0.0
Tense / ‘highly strung’ 0.8 1.3 3.9 -1.2 -1.3 0.0 0.9 -2.0 -1.0 -1.9 -0.4 -0.3 -1.1 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.6 0.0 -0.2 0.0 -1.5 -1.6 -0.2 0.1 0.2 0.6 -0.5 -0.4
Hair/balding pattern: Pattern 4 0.2 0.5 2.3 -0.1 0.1 0.0 1.5 -0.4 0.1 -1.0 0.4 -0.2 -0.5 1.1
Birth weight of first child 0.3 0.6 3.0 0.7 1.3 0.0 -1.7 0.8 0.2 -0.0 -0.5 0.2 0.3 -0.5
Peak expiratory flow (PEF) 0.7 1.6 4.4 -1.7 0.4 0.0 2.1 -0.2 -1.1 -1.0 -0.5 -1.4 1.5 1.8
Pulse wave reflection index 0.6 0.8 2.6 0.9 1.1 0.0 -1.4 0.2 1.6 0.8 1.1 0.2 0.2 0.1
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.8 0.2 0.5 0.0 0.1 0.4 0.4 0.1 1.3 -0.7 0.1 0.7
Loud music exposure frequency 0.5 0.5 1.3 0.4 -0.1 0.0 1.1 0.8 -0.8 -1.0 0.8 -0.8 0.3 0.8
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 5.7 -1.1 -0.3 0.0 1.4 0.3 -0.2 1.7 -1.1 2.4 -0.5 -2.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 1.9 0.5 0.1 0.0 -1.4 0.6 0.3 0.5 -0.6 -0.0 0.7 -0.4
Blood clot in the leg (DVT) 0.5 0.6 4.1 1.0 0.1 0.0 0.6 -0.5 0.6 -0.1 2.0 0.5 -0.0 0.8
Medication: Paracetamol 0.3 0.5 1.5 -0.1 -0.8 0.0 0.1 -0.6 -1.1 -1.2 0.2 -0.6 -0.6 1.0
Headache pain in last month 0.6 1.1 3.6 -0.8 -1.3 0.0 -1.0 -0.3 -0.5 -1.9 1.4 -1.1 0.1 1.3
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 12.5 0.4 3.5 0.0 0.4 0.6 1.1 0.9 0.5 0.7 0.4 0.4
Glaucoma (self-reported) 0.6 0.7 2.5 -0.3 0.5 0.0 1.6 -0.4 -0.5 1.1 -0.1 1.2 0.1 -1.2
Gout (self-reported) 0.8 1.1 4.1 0.9 -1.6 0.0 -0.3 0.4 -1.9 -0.1 -2.0 -0.2 0.6 0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 4.1 -0.4 -1.4 0.0 -0.1 -0.9 -0.7 -1.2 -0.0 -2.0 -0.6 0.3
Medication: Amlodipine 0.9 1.2 6.2 0.3 -0.5 0.0 1.6 -0.5 -1.4 -0.4 -2.5 -1.3 0.2 -0.5
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.0 -0.4 -0.7 0.0 -1.3 -1.7 -1.3 -1.6 -0.3 -0.8 -1.0 0.2
Birth weight 0.5 1.1 4.8 0.1 0.9 0.0 2.2 -1.0 -0.2 -1.1 -0.0 0.9 -1.8 -0.9
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.8 1.4 -0.1 0.0 1.7 0.5 0.9 0.0 0.6 0.6 -0.0 -0.7
High blood pressure (siblings) 0.2 0.3 0.7 0.7 -0.1 0.0 -0.8 0.4 0.4 0.7 -0.8 -0.5 0.2 0.4
Forced vital capacity (FVC), Best measure 0.8 3.1 9.9 -3.1 -2.4 0.0 -0.1 -1.8 -3.2 -2.2 -0.5 -0.0 -0.3 0.1
Body fat percentage 0.3 1.0 5.2 1.0 0.2 0.0 1.0 -0.3 -0.1 -2.3 -0.7 -1.8 -0.0 0.3
Leg fat percentage (right) 0.5 1.8 5.9 2.0 1.3 0.0 2.4 0.4 0.9 -2.0 -0.0 -1.8 0.3 0.5
Arm fat-free mass (right) 0.8 4.0 15.8 -0.3 -0.2 0.0 2.3 -2.8 -1.4 -4.0 0.8 -2.7 0.6 2.2
Exposure to tobacco smoke outside home 0.1 0.2 0.5 0.7 -0.2 0.0 -0.7 0.2 0.7 0.2 0.1 0.6 -0.3 -0.2
Comparative body size at age 10 0.5 1.4 4.9 -0.7 0.1 0.0 2.2 -2.2 -0.6 -1.2 -1.7 -1.0 -0.1 0.0
Number of full brothers 1.0 1.3 4.8 0.1 2.2 0.0 -0.5 0.9 1.5 2.0 0.5 0.2 1.1 0.4
Worry too long after embarrassment 0.2 0.4 1.2 0.9 -0.7 0.0 0.7 0.2 1.1 -0.6 0.4 0.4 -0.9 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.0 -0.4 -1.0 0.0 -1.4 -1.4 0.1 -0.3 0.4 0.8 -1.2 -1.0
Wheeze or whistling in the chest in last year 0.3 0.6 1.8 0.5 0.3 0.0 -0.4 0.6 0.8 0.6 0.2 1.1 -1.4 -1.2
Number of children fathered 0.3 0.4 2.9 0.0 0.8 0.0 -0.7 -0.1 -0.1 -0.1 -1.7 -0.3 -0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 3.1 1.3 -0.4 0.0 -0.8 0.7 -0.6 -0.7 -0.1 1.0 -1.8 -0.8
Age at first live birth 0.7 1.3 4.0 1.1 -0.8 0.0 -1.0 2.0 -0.4 0.0 0.4 -1.6 1.9 1.1
Pulse wave peak to peak time 0.8 0.9 2.8 -0.4 0.1 0.0 0.2 1.1 -1.1 0.9 -1.2 1.7 -0.6 -1.3
Health satisfaction 0.9 1.1 3.4 0.6 -0.3 0.0 -0.5 -1.2 0.2 -0.6 1.9 -1.7 0.8 1.7
Shortness of breath walking on level ground 0.8 1.0 4.3 -0.6 0.2 0.0 0.5 -1.0 0.1 -1.7 0.9 -2.1 -0.1 0.9
Qualifications: College or University degree 0.3 1.0 2.7 0.0 0.1 0.0 1.5 1.0 0.8 0.1 1.0 1.4 -1.6 -1.1
Eye problems/disorders: None of the above 1.4 1.6 6.3 -2.0 -1.0 0.0 -0.6 -1.3 -2.5 -0.4 -1.9 0.1 -0.8 -0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.6 -0.6 0.0 0.1 0.2 0.4 -0.7 0.7 -0.6 0.2 0.6
Emphysema/chronic bronchitis 0.5 0.5 1.9 -1.4 -1.2 0.0 0.8 -0.4 -0.3 0.5 0.1 -0.3 1.0 -0.2
Medication for pain relief, constipation, heartburn 0.9 1.5 5.3 -0.3 1.6 0.0 -1.3 0.6 0.3 2.3 -1.3 1.5 0.5 -1.7
Neck or shoulder pain in last month 0.6 0.9 3.3 -0.4 -1.8 0.0 1.2 -0.9 -0.3 -0.2 1.4 -0.5 -1.0 0.6
Medication: Blood pressure 0.6 1.1 5.9 0.0 -2.4 0.0 -0.6 -0.7 -0.6 -1.6 -0.5 -1.6 -0.1 0.2
Angina (self-reported) 0.4 0.6 2.0 0.2 0.1 0.0 -0.0 -1.1 1.4 -0.9 1.0 -0.6 -0.4 0.8
Migraine (self-reported) 0.7 0.8 5.6 -0.7 -0.5 0.0 -0.9 -2.4 -0.1 -0.8 -0.9 -0.5 -0.5 0.1
Medication: Ibuprofen 0.3 0.3 1.6 -0.2 -1.3 0.0 0.3 -0.6 1.0 -0.6 0.3 0.1 -0.2 0.2
Medication: Allopurinol 0.5 0.6 2.0 1.3 -0.9 0.0 -0.3 0.5 -1.0 0.8 -1.4 0.2 0.5 -0.4
Medication: Omeprazole 1.0 1.2 3.8 -0.5 -1.9 0.0 0.0 -1.8 -0.7 -1.1 -0.8 0.5 -1.6 -1.0
Medication: Seretide 50 evohaler 0.4 0.4 1.4 0.7 1.2 0.0 0.1 -0.0 0.6 -0.3 0.9 -0.4 -0.0 1.1
Mean time to correctly identify matches 1.2 2.2 13.3 0.6 -0.5 0.0 0.8 -0.4 0.3 -3.6 1.2 -2.1 -1.8 0.5
Heart disease (mother) 0.4 0.4 1.1 0.8 -0.0 0.0 -0.6 0.1 0.8 -0.9 1.1 -1.0 -0.5 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 5.8 2.1 0.5 0.0 2.2 2.4 0.4 0.7 -0.0 -1.6 1.7 1.2
Whole body fat mass 0.5 2.0 9.7 0.6 -0.0 0.0 1.8 -1.3 -0.6 -3.1 -0.2 -2.4 0.3 1.0
Leg fat mass (right) 0.5 2.1 8.0 1.0 0.4 0.0 2.5 -1.1 -0.2 -2.8 0.0 -2.2 0.3 0.9
Arm predicted mass (right) 0.9 4.4 19.3 -0.5 -0.5 0.0 2.2 -2.8 -1.6 -4.4 0.8 -2.8 0.4 2.2
Pulse rate, automated reading 2.4 7.8 16.9 3.9 1.6 0.0 2.0 2.0 2.6 -2.4 3.5 -4.0 1.4 4.1
Alcohol intake frequency. 0.7 1.6 4.3 -1.4 1.2 0.0 -0.3 -2.1 -0.9 0.8 -1.1 -1.8 1.5 1.2
Comparative height size at age 10 0.4 2.4 7.3 -0.7 0.2 0.0 -0.1 -1.0 -1.1 -2.0 1.8 -2.5 1.7 2.7
Number of full sisters 0.5 0.6 2.0 -0.5 -0.2 0.0 0.5 -0.0 -0.5 1.2 -0.2 1.4 -0.9 -1.0
Suffer from ‘nerves’ 0.3 0.5 3.1 -0.6 -0.6 0.0 0.0 -1.8 -0.6 -0.3 -0.1 0.6 -0.7 -0.4
Overall health rating 1.0 2.2 7.1 -0.5 -0.8 0.0 -0.1 -2.7 -0.3 -1.1 1.7 -2.4 1.7 1.9
Chest pain or discomfort 0.2 0.3 0.7 -0.2 -0.5 0.0 0.4 -0.2 0.8 -0.9 0.5 -0.7 -0.6 0.5
Had major operations 0.3 0.4 2.7 0.6 -0.0 0.0 -0.7 -0.1 -0.2 0.1 1.6 0.7 -0.4 -0.2
Age at last live birth 1.3 1.9 6.2 2.5 0.3 0.0 -1.1 2.3 1.1 -0.3 1.1 -1.2 1.6 1.2
Family relationship satisfaction 0.2 0.3 0.7 0.4 0.5 0.0 0.7 -0.5 0.4 -0.3 0.8 0.2 -0.9 0.3
Leg pain on walking 1.0 1.2 3.6 -0.1 -1.9 0.0 0.1 -1.8 -0.0 -1.5 0.2 -1.9 -0.0 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 4.8 0.7 1.5 0.0 1.1 1.1 0.0 2.2 -0.2 -0.0 0.9 0.4
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.1 0.6 -0.0 0.0 -0.8 0.0 0.6 0.8 0.6 0.5 1.1 0.2
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 8.4 -2.3 -2.9 0.0 -0.5 -0.7 -1.4 -0.7 -0.4 -0.0 0.5 -0.2
Medication: Aspirin 1.2 1.5 5.9 0.1 -1.7 0.0 2.4 -0.7 -0.1 -1.8 1.3 -0.9 -0.8 0.9
Supplements: Vitamin C 0.3 0.3 1.4 0.1 0.1 0.0 1.2 0.5 -0.4 -0.0 -1.1 0.4 -0.7 -0.1
Knee pain experienced in last month 0.3 0.5 1.2 0.9 -0.8 0.0 -0.6 -0.6 -1.1 -1.1 -0.3 -0.8 -0.1 0.7
Hypertension (Self-reported) 0.3 0.8 3.8 1.5 -1.9 0.0 0.9 0.1 -0.7 -0.1 0.2 -1.0 0.7 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 5.9 -1.0 -2.4 0.0 -1.5 0.0 -2.0 -0.5 -1.0 -1.2 1.0 0.4
Illnesses of father: Heart disease 0.5 0.8 2.7 -0.4 -1.6 0.0 1.2 -1.6 -0.6 -1.0 0.2 -0.3 -0.0 0.5
Illnesses of siblings: Diabetes 0.7 0.9 3.1 0.5 0.9 0.0 -1.7 0.7 0.8 1.8 0.9 0.1 1.1 0.2
Smoking status: Previous 0.6 0.9 3.9 -0.5 -0.4 0.0 1.7 -0.5 -0.3 -0.5 -0.2 1.1 -2.0 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 4.6 -0.5 0.2 0.0 2.1 0.0 -0.2 0.4 1.7 -0.7 2.0 0.9
Whole body fat-free mass 0.8 4.4 16.4 -1.2 -0.9 0.0 1.9 -3.5 -2.1 -4.0 0.4 -2.4 0.4 1.7
Leg fat-free mass (right) 0.8 4.2 15.7 -1.6 -1.1 0.0 1.9 -3.6 -2.2 -4.0 -0.1 -1.9 -0.2 1.2
Arm fat percentage (left) 0.3 1.2 5.0 0.8 -0.0 0.0 1.8 -1.0 -0.3 -2.2 -1.3 -1.2 -0.7 -0.5
Average weekly red wine intake 0.3 0.4 1.8 0.1 0.8 0.0 0.9 0.8 0.0 -0.0 -1.4 0.2 -0.4 -0.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.3 -0.5 -0.4 0.0 -1.5 -0.3 -0.4 0.4 -1.2 0.8 0.1 -1.5
Mood swings 0.5 0.8 3.2 -0.6 -0.3 0.0 -1.4 -1.3 -0.5 -1.8 -0.1 -0.9 -0.1 0.9
Loneliness, isolation 0.5 0.7 2.4 -1.2 -1.5 0.0 -0.9 -0.9 -0.8 -0.8 0.7 -0.2 0.5 0.9
Long-standing illness, disability or infirmity 1.0 1.6 4.8 1.5 0.2 0.0 1.7 0.3 0.1 -1.6 1.3 -2.2 -0.4 1.8
Ever had bowel cancer screening 1.1 1.3 2.7 -0.7 -1.4 0.0 -0.8 -0.1 -1.6 -1.6 -0.8 -1.6 0.9 1.4
Diabetes diagnosed by doctor 0.9 1.5 7.2 1.7 1.3 0.0 0.5 0.4 0.3 2.7 1.0 0.9 1.1 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 3.9 1.6 0.1 0.0 -1.1 2.0 1.6 -0.5 1.2 -1.2 0.6 1.6
Friendships satisfaction 0.7 0.9 3.4 1.2 0.5 0.0 0.6 0.5 1.8 -0.7 1.8 -0.2 -0.6 0.6
Qualifications: nursing, teaching 1.5 2.3 7.3 0.6 1.4 0.0 1.1 -0.7 1.1 2.4 -0.7 2.7 -1.0 -2.3
Commuting to job workplace: Walk 0.8 0.8 4.6 -0.3 -0.2 0.0 0.6 -0.5 0.5 0.7 -0.9 1.4 -0.4 -2.1
Eye problems/disorders: Cataract 0.8 0.9 2.6 0.8 0.6 0.0 1.6 1.2 1.5 -1.0 0.9 -0.4 -0.2 0.9
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.7 1.0 0.7 0.0 -1.6 0.1 0.9 1.0 0.4 0.3 0.0 -1.0
Medication for cholesterol 0.2 0.4 1.9 -0.3 1.4 0.0 -0.3 0.1 0.4 -0.5 -0.7 0.7 -0.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.4 1.4 0.7 0.0 1.6 1.7 0.8 -0.3 0.9 -0.8 0.5 1.9
Back pain experienced in last month 0.4 0.6 2.1 1.4 0.7 0.0 0.3 0.2 -0.5 -0.4 0.8 -1.4 -0.9 0.4
Mineral and other dietary supplements 0.4 0.5 3.1 -1.8 -0.6 0.0 -0.4 -0.5 -1.0 -0.3 -0.1 -0.3 0.7 0.0
Breast cancer (self-reported) 0.9 1.1 3.5 -1.4 -0.9 0.0 -1.9 -0.8 -1.7 -0.1 -1.2 -0.7 0.5 0.4
Asthma (self-reported) 0.4 0.7 2.9 1.0 1.7 0.0 0.1 -0.4 0.0 -1.0 -0.1 0.5 -1.5 -0.3
Osteoporosis (self-reported) 1.0 1.2 4.5 1.4 -0.5 0.0 -1.0 1.4 -0.3 -0.9 0.3 -0.6 1.4 2.1
Osteoarthritis (self-reported) 1.3 1.7 6.6 -1.0 -1.4 0.0 -1.6 -1.1 -2.6 -0.6 -2.2 -0.7 0.0 -0.0
Medication: Aspirin 1.0 1.3 4.5 0.5 -1.4 0.0 2.1 -0.7 0.0 -1.7 1.5 -0.5 -1.2 0.7
Medication: Gliclazide 3.2 3.6 10.1 2.4 3.2 0.0 1.4 1.4 3.0 1.3 2.8 -0.4 0.8 0.9
Illnesses of father: None of the above (group 1) 1.7 2.2 9.3 0.7 3.0 0.0 -0.8 0.7 2.5 1.6 0.7 1.7 -0.1 -0.4
Smoking status: Current 0.9 1.5 5.4 0.7 1.5 0.0 0.0 -0.2 1.3 1.4 0.6 -0.7 2.3 1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 4.9 -0.7 -1.5 0.0 0.6 0.7 -0.8 -2.2 -1.3 -0.4 -0.7 0.0
Whole body water mass 0.8 4.4 17.4 -1.2 -0.9 0.0 2.0 -3.4 -2.1 -4.2 0.5 -2.4 0.3 1.7
Leg predicted mass (right) 0.8 4.1 15.2 -1.6 -1.1 0.0 1.9 -3.6 -2.1 -3.9 -0.1 -1.9 -0.2 1.2
Arm fat mass (left) 0.5 2.1 10.4 0.5 -0.2 0.0 2.0 -1.7 -0.7 -3.2 -0.7 -2.0 -0.3 0.5
Number of self-reported non-cancer illnesses 0.6 1.0 4.9 1.0 -2.2 0.0 -0.7 -0.6 -1.3 -0.4 0.0 -0.2 -1.3 -0.5
Average weekly champagne plus white wine intake 0.7 1.0 4.4 0.7 0.3 0.0 0.6 1.7 2.1 0.1 1.7 0.2 -0.2 -0.1
Miserableness 0.6 1.1 6.5 -0.4 -0.5 0.0 -2.5 -1.2 0.5 -1.2 1.2 -0.1 0.4 0.8
Guilty feelings 0.7 1.0 4.2 -0.4 -1.1 0.0 -0.2 -1.3 -0.3 -0.1 -0.4 2.1 -1.4 -1.4
Wears glasses or contact lenses 1.2 1.4 6.3 -1.4 -1.9 0.0 0.0 -0.9 -0.1 -2.5 -0.4 -1.0 -1.1 0.4
Ever taken oral contraceptive pill 0.4 0.4 1.1 0.5 0.7 0.0 -0.7 -0.0 0.3 0.9 1.0 0.3 1.0 0.7
Hearing aid user 1.5 1.7 4.9 -1.8 -2.2 0.0 1.1 -1.0 -1.5 -1.8 -0.9 0.3 -1.0 -1.1
Mother’s age at death 0.8 1.1 4.2 0.5 1.9 0.0 -0.0 1.1 -0.3 2.1 -0.9 1.0 0.1 -0.4
Financial situation satisfaction 1.1 1.4 3.8 0.3 1.6 0.0 -1.6 0.9 1.3 -0.3 1.9 -0.7 0.6 1.7
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.9 -1.4 -1.3 0.0 -0.9 -0.3 -1.1 0.9 0.2 1.0 -0.0 0.2
Commuting to job workplace: Public transport 1.1 1.3 4.4 -0.6 0.6 0.0 1.7 -0.9 1.1 -0.1 0.3 1.6 -2.1 -1.3
Eye problems/disorders: Glaucoma 0.7 0.8 2.7 0.5 0.9 0.0 1.1 0.0 0.5 1.6 0.9 0.3 1.7 0.2
Medication: Blood pressure 0.3 0.6 1.8 1.4 -0.5 0.0 0.8 1.0 0.4 0.2 0.8 -1.1 0.7 -0.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 3.8 0.8 -1.2 0.0 -0.4 -1.9 0.1 -1.1 0.8 -1.2 -0.5 -0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 4.2 0.6 0.2 0.0 -0.1 -0.2 0.1 0.1 -2.1 0.8 -1.3 -1.1
High cholesterol (Self-reported) 0.9 1.5 10.2 0.4 -3.2 0.0 -0.4 0.1 0.1 -0.0 2.4 0.3 0.1 0.4
Medication: Bendroflumethiazide 1.0 1.5 11.0 -0.2 -3.3 0.0 0.8 -1.3 -1.2 -0.9 -0.5 -0.2 -0.0 -1.0
Medication: Paracetamol 0.7 1.1 2.3 -0.8 -1.4 0.0 -0.1 -1.5 -1.5 -1.5 0.5 -0.5 -0.8 1.0
Medication: Lisinopril 0.3 0.4 1.8 1.0 0.8 0.0 0.2 0.9 0.3 1.4 -0.3 0.5 -0.2 -0.4
Medication: Atorvastatin 0.7 0.8 6.1 -0.3 -2.5 0.0 -0.2 -0.8 -1.0 0.0 0.8 -0.6 -0.1 0.3
Illnesses of father: High blood pressure 0.5 0.6 2.4 0.5 0.5 0.0 1.5 0.3 -0.1 1.2 -1.1 -0.0 -0.3 -1.1
Alcohol drinker status: Never 0.7 0.9 3.1 -1.8 -1.6 0.0 -0.0 -0.2 -1.5 -0.6 -0.6 -0.9 0.5 0.2
Ever smoked 0.5 0.9 2.7 0.8 1.6 0.0 1.6 0.3 1.0 0.2 0.6 1.2 -0.7 0.2
Basal metabolic rate 0.8 4.2 17.1 -1.0 -0.6 0.0 2.2 -3.2 -1.9 -4.1 0.4 -2.5 0.3 1.6
Leg fat percentage (left) 0.5 1.8 6.1 1.7 1.1 0.0 2.5 0.2 0.7 -1.9 -0.2 -2.1 0.4 0.9
Arm fat-free mass (left) 0.9 4.6 19.9 -0.4 -0.4 0.0 2.0 -2.7 -1.5 -4.5 0.7 -3.2 0.7 2.4
Number of operations (self-reported) 0.5 0.7 1.9 0.5 -1.4 0.0 -1.3 -0.3 -1.1 -0.8 0.8 -0.9 0.3 0.9
Average weekly beer plus cider intake 0.7 1.0 2.9 1.6 1.2 0.0 -0.1 1.3 0.4 1.3 0.4 1.7 -0.5 -0.6
Irritability 1.1 1.9 8.2 -0.2 -0.8 0.0 2.2 -0.3 0.4 -2.9 -0.3 -2.3 0.0 1.0
Risk taking 0.9 1.3 5.7 1.8 0.6 0.0 -1.4 2.4 1.0 -0.7 -0.7 0.2 -0.1 0.7
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.9 1.0 1.4 0.0 0.5 1.0 1.3 -0.7 -0.5 -1.7 0.8 0.2
Fractured/broken bones in last 5 years 0.5 0.7 3.0 1.7 1.1 0.0 -1.1 -0.2 0.0 0.0 1.4 0.0 -0.2 0.5
Age started oral contraceptive pill 0.5 0.6 3.2 -0.4 -1.8 0.0 0.4 -0.8 -1.1 -1.1 -0.3 0.1 -0.4 0.2
Diastolic blood pressure, automated reading 0.4 1.2 6.5 2.5 0.1 0.0 1.7 -0.0 0.2 1.0 1.1 -0.8 1.0 0.1
Ever depressed for a whole week 0.5 0.6 4.1 0.1 -0.2 0.0 0.9 0.4 0.3 -0.6 2.0 -0.9 0.1 0.4
Unable to work because of sickness or disability 0.9 1.2 4.7 0.9 1.6 0.0 -0.2 -0.6 2.2 1.1 1.7 -0.6 0.8 0.1
Commuting to job workplace: Cycle 0.1 0.1 0.5 0.3 -0.1 0.0 0.7 0.6 -0.2 -0.3 0.1 -0.0 -0.5 0.1
Myopia 0.7 1.0 3.3 0.2 0.9 0.0 1.8 -0.1 0.3 -0.1 -1.8 -0.1 -0.9 -1.6
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.6 -1.6 1.6 0.0 -1.1 0.5 -0.0 0.6 -0.6 1.3 -0.1 0.2
Cholesterol lowering medication 0.8 1.2 4.9 -1.1 -2.2 0.0 -1.2 -0.8 -1.9 -1.2 0.4 -0.4 -0.1 0.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.5 0.2 -1.0 0.0 -0.3 -0.3 -0.0 -1.0 -0.4 0.3 -1.6 -0.7
Pain experienced in last month 0.8 1.3 4.1 -1.0 0.8 0.0 0.2 0.3 0.7 1.7 -1.2 2.0 0.4 -1.9
Supplements: Calcium 0.9 1.0 2.8 1.0 -0.7 0.0 0.1 0.7 0.3 0.5 1.4 -1.5 1.3 1.7
Basal cell carcinoma (self-reported) 0.7 0.8 2.8 -1.4 -1.7 0.0 0.4 -1.4 -1.3 -0.2 0.2 -0.4 -0.6 -0.1
Heart attack/myocardial infarction (self-reported) 1.1 1.5 4.2 0.5 0.4 0.0 0.1 -1.2 1.2 -1.3 1.8 -2.1 -0.1 1.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 4.3 1.0 0.1 0.0 0.9 -0.5 0.7 0.1 2.1 0.5 0.0 0.7
Heart disease (siblings) 0.6 0.7 2.4 0.8 1.1 0.0 0.8 1.5 0.9 0.7 -0.0 -0.9 0.3 0.6
Alcohol drinker status: Previous 0.4 0.4 1.9 0.5 1.4 0.0 0.2 -0.2 0.7 0.9 0.4 0.2 -0.8 0.2
Pack years of smoking 1.7 2.5 6.5 -1.5 -2.4 0.0 -1.7 0.1 -1.3 -0.7 -0.5 -2.5 2.5 1.5
Impedance of whole body 0.4 2.1 9.1 -0.8 0.3 0.0 -2.5 2.0 0.2 3.0 0.2 1.4 0.5 -0.8
Leg fat mass (left) 0.5 2.0 7.5 0.8 0.4 0.0 2.5 -1.3 -0.3 -2.7 -0.1 -2.3 0.3 1.0
Arm predicted mass (left) 0.8 4.2 17.7 -0.7 -0.6 0.0 1.9 -2.9 -1.7 -4.2 0.5 -2.9 0.6 2.0