TWAS hub - TSC22D4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.0560	0.0270	7.8e-03	0.019	NA	0.032	NA	0.020	3.5e-02	NA	9.0e-03	NA	3.2e-02
2	GTEx	Breast Mammary Tissue (Female)	0.0413	0.0420	1.9e-01	0.000	NA	0.010	NA	0.006	3.1e-01	NA	1.6e-01	NA	2.0e-01
3	GTEx	Heart Atrial Appendage	0.1490	0.0600	5.9e-04	0.129	NA	0.083	NA	0.103	2.1e-06	NA	1.4e-04	NA	2.3e-05
4	GTEx	Heart Left Ventricle	0.1161	0.0493	1.9e-04	0.084	NA	0.085	NA	0.082	3.3e-05	NA	2.9e-05	NA	3.8e-05
5	GTEx	Lung	0.0659	0.0292	8.4e-04	0.064	NA	0.007	NA	0.030	1.2e-05	NA	9.4e-02	NA	2.3e-03
6	GTEx	Muscle Skeletal	0.0783	0.0260	5.7e-07	0.079	NA	0.067	NA	0.074	3.4e-08	NA	4.0e-07	NA	9.1e-08
7	GTEx	Prostate	0.2000	0.0800	2.8e-03	0.005	NA	0.017	NA	0.045	2.4e-01	NA	1.2e-01	NA	2.8e-02
8	METSIM	Adipose	0.0956	0.0313	4.9e-09	0.051	0.074	0.085	0.075	0.066	4.2e-08	3.0e-11	1.1e-12	2.5e-11	4.2e-10
9	YFS	Blood	0.1151	0.0321	0.0e+00	0.039	0.064	0.064	0.064	0.060	9.8e-13	5.4e-20	5.7e-20	4.1e-20	4.7e-19
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0199	0.0123	6.4e-04	0.036	0.029	0.033	NA	0.033	6.4e-05	2.5e-04	1.1e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6	7	8	9	10
Blood Platelet Count	15.5	180.2	282.2	16.0	13.9	16.8	14.5	15.2	14.0	11.4	10.1	14.2
Had other major operations	7.8	9.5	13.1	3.2	3.2	3.1	3.6	3.5	3.6	2.8	2.8	3.2
Alcohol intake frequency.	7.3	17.1	22.8	4.7	4.2	4.0	4.6	4.6	4.8	3.4	4.3	4.4
Hand grip strength (left)	6.8	17.9	30.9	-4.2	-4.8	-3.6	-5.2	-5.0	-5.6	-2.1	-3.9	-4.9
Breast cancer (self-reported)	6.0	7.2	11.4	2.9	2.6	3.0	3.4	3.3	3.0	1.2	2.4	3.0
Breast Cancer	5.8	14.0	19.8	-4.4	-3.9	-4.4	-4.2	-4.3	-3.6	-2.6	-3.6	-4.1
Heel T-Score	5.6	44.3	70.9	-7.3	-7.2	-8.4	-7.3	-7.4	-5.9	-7.3	-4.5	-7.1
Fluid intelligence score	5.5	11.3	16.9	-3.5	-3.6	-3.5	-4.0	-4.1	-3.3	-2.8	-2.9	-3.9
Heart disease (mother)	5.4	6.6	9.6	-3.1	-2.7	-2.6	-2.3	-2.7	-2.9	-2.8	-2.6	-2.6
Qualifications: College or University degree	5.3	16.8	25.1	-5.0	-4.1	-4.7	-4.4	-4.6	-3.9	-4.1	-3.4	-4.5
Exposure to tobacco smoke at home	5.2	5.8	9.9	3.2	2.6	2.4	2.4	2.6	2.9	2.2	1.7	2.7
Hand grip strength (right)	5.0	13.5	24.8	-3.5	-4.0	-3.0	-4.7	-4.2	-5.0	-1.8	-3.5	-4.2
Comparative body size at age 10	4.4	12.2	16.8	-3.2	-4.0	-4.1	-3.5	-4.1	-2.9	-3.9	-3.1	-4.0
Reason for reducing amount of alcohol drunk: Health precaution	4.4	5.1	10.1	-3.2	-2.3	-2.6	-2.8	-2.7	-2.2	-1.5	-0.8	-2.6
Bilateral oophorectomy (both ovaries removed)	4.3	5.0	10.4	2.8	2.2	2.5	2.4	2.5	3.2	1.2	1.6	2.2
High blood pressure (siblings)	4.2	6.1	12.0	-1.6	-2.9	-2.4	-2.8	-2.9	-1.5	-2.5	-3.5	-2.8
Ever used hormone-replacement therapy (HRT)	4.0	5.1	7.7	2.6	2.4	2.8	2.4	2.7	2.7	2.0	1.2	2.3
Ever had prostate specific antigen (PSA) test	3.8	4.4	7.3	-2.7	-2.2	-2.6	-1.7	-2.0	-2.1	-2.2	-2.0	-2.2
Qualifications: None of the above	3.6	7.8	15.8	4.0	2.9	3.6	2.2	3.0	3.2	1.8	2.4	2.8
Mean Putamen Volume	3.4	3.9	8.5	-2.9	-1.9	-1.8	-2.6	-1.9	-2.4	0.4	-1.6	-2.2
Number of incorrect matches in round	3.3	5.5	8.7	-2.3	-2.9	-2.6	-2.6	-2.9	-2.2	-1.5	-2.0	-3.0
Illnesses of father: None of the above (group 1)	3.3	4.1	8.1	1.8	1.8	1.7	2.7	2.3	2.1	1.4	2.9	2.0
Risk taking	3.3	4.8	7.3	-2.3	-2.0	-1.9	-2.4	-2.1	-2.7	-2.6	-2.5	-2.1
Lung cancer (father)	3.2	3.7	8.9	3.0	1.4	2.0	1.9	2.0	2.9	1.8	1.0	1.6
Illnesses of siblings	3.1	4.4	8.5	1.7	2.3	1.7	2.9	2.6	2.1	0.9	2.6	2.4
Number of children fathered	3.0	3.4	6.1	1.6	2.1	1.6	2.2	2.3	2.5	1.2	1.2	2.3
Impedance of leg (left)	2.9	14.2	20.4	-4.4	-4.1	-4.5	-4.0	-4.5	-3.9	-3.0	-3.1	-4.1
Impedance of leg (right)	2.8	13.7	21.0	-4.3	-4.0	-4.6	-3.8	-4.4	-3.7	-3.2	-3.0	-4.0
Serious illness, injury or assault to yourself	2.8	3.4	5.3	2.3	1.9	1.7	1.9	2.0	2.3	1.6	1.3	2.1
Age at first live birth	2.8	5.0	8.1	-2.7	-2.6	-2.6	-2.6	-2.8	-2.5	-0.8	-0.5	-2.7
Impedance of whole body	2.8	14.1	22.0	-4.7	-3.7	-4.7	-3.6	-4.2	-3.9	-3.4	-3.3	-3.9
Impedance of arm (left)	2.7	12.4	20.0	-4.4	-3.3	-4.5	-3.1	-3.7	-3.6	-3.7	-3.4	-3.4
Qualifications: nursing, teaching	2.7	4.2	8.1	-2.8	-2.0	-2.0	-2.0	-1.9	-2.6	-1.6	-1.9	-2.2
Hair/balding pattern: Pattern 2	2.6	3.3	5.2	-1.8	-2.1	-1.6	-2.0	-2.2	-2.3	0.3	-1.8	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	8.9	-2.0	-2.7	-3.0	-2.8	-2.5	-2.5	-1.9	-2.7	-2.7
Verbal and Numeric Reasoning (VNR)	2.5	6.1	8.9	-2.7	-2.6	-2.7	-2.8	-3.0	-2.7	-1.7	-2.5	-2.7
Age at last live birth	2.5	3.7	6.6	-2.4	-2.2	-2.3	-2.1	-2.6	-2.1	-0.2	0.5	-2.3
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.1	4.4	2.0	1.6	1.7	2.1	2.0	2.1	1.2	1.8	1.9
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	7.2	1.2	1.3	0.9	1.6	1.3	1.6	2.2	2.7	1.4
Qualifications: A levels/AS levels or equivalent	2.4	5.3	7.5	-2.7	-2.3	-2.4	-2.7	-2.7	-2.1	-1.7	-2.4	-2.7
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	6.7	2.1	1.5	1.2	2.2	1.8	2.6	0.8	2.0	1.8
Hearing aid user	2.3	2.6	5.6	1.7	1.6	1.2	1.7	1.5	1.8	1.6	2.4	1.6
Cholesterol lowering medication	2.3	3.4	6.8	-1.4	-2.4	-2.1	-2.5	-2.6	-1.5	-0.7	-0.9	-2.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.9	-2.1	-1.5	-1.3	-2.3	-1.7	-2.4	-2.0	-2.0	-1.9
Blood clot in the leg (DVT)	2.2	2.9	4.5	2.1	1.9	1.8	2.0	1.9	1.9	-1.1	-0.8	1.9
Fed-up feelings	2.1	3.8	5.9	2.1	2.0	1.8	2.3	2.4	1.6	1.6	2.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.9	8.0	-2.1	-2.5	-2.8	-2.7	-2.5	-2.2	-1.4	-1.9	-2.5
Illnesses of father: High blood pressure	2.1	2.6	4.4	-1.6	-1.8	-1.5	-1.6	-1.7	-1.4	-1.8	-1.7	-2.1
Medication for hormone replacement therapy	2.0	2.2	5.0	1.8	1.7	2.0	1.0	1.6	1.2	2.2	1.0	1.2
Knee pain experienced in last month	2.0	3.2	5.6	1.4	1.9	2.0	2.1	2.4	1.8	1.7	1.6	1.9
Alcohol drinker status: Previous	2.0	2.2	5.6	2.4	1.3	1.7	1.2	1.2	1.5	2.0	1.4	1.1
Diabetes (mother)	1.9	2.4	5.8	1.7	1.4	1.1	2.4	1.7	2.0	1.4	0.6	1.8
Impedance of arm (right)	1.9	9.1	15.7	-4.0	-2.7	-3.8	-2.8	-3.1	-2.9	-3.1	-3.0	-2.9
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	4.9	-2.2	-1.7	-2.1	-2.0	-1.9	-1.8	-1.5	-1.5	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	3.8	1.9	1.7	1.5	1.9	1.7	1.8	-1.6	-1.0	1.7
Blood White Count	1.8	13.6	20.2	3.2	4.5	4.5	4.4	4.3	3.5	2.6	2.9	4.4
Exposure to tobacco smoke outside home	1.8	2.4	3.8	1.9	1.6	1.9	1.7	1.9	1.6	1.3	0.6	1.7
Handedness (chirality/laterality): Left-handed	1.8	2.2	4.1	-1.2	-1.6	-0.6	-2.0	-1.7	-1.7	-1.3	-1.8	-1.6
Medication: Paracetamol	1.8	2.8	7.9	0.9	1.7	1.3	2.0	1.8	1.2	1.7	2.8	1.8
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.7	1.8	1.5	1.4	1.7	1.5	2.2	1.0	0.2	1.4
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.2	-1.4	-1.6	-1.4	-1.6	-1.7	-1.3	-1.5	-0.8	-1.8
Average weekly champagne plus white wine intake	1.7	2.4	5.4	-2.3	-1.5	-1.7	-1.5	-1.4	-2.2	-0.4	-1.4	-1.4
Intelligence (Savage-Jansen 2018)	1.6	4.9	8.3	-2.9	-2.2	-2.2	-2.6	-2.6	-2.7	-0.7	-2.3	-2.2
Prostate Cancer	1.6	2.2	4.7	1.6	2.0	2.2	1.1	1.8	1.2	0.8	0.9	1.9
Primary Biliary Cirrhosis	1.6	2.2	3.9	-1.3	-1.5	-1.7	-1.5	-1.6	-1.4	-2.0	-1.7	-1.5
Mouth/teeth dental problems: Dentures	1.6	2.7	5.5	2.0	1.7	1.1	1.9	1.9	2.3	1.1	0.9	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.5	-1.9	-1.3	-1.4	-1.7	-1.4	-1.1	-2.4	-0.4	-1.3
Average weekly red wine intake	1.6	2.4	4.7	-1.0	-1.9	-1.2	-2.2	-2.1	-0.9	-1.0	-1.7	-2.1
Friendships satisfaction	1.6	1.9	3.7	-1.6	-1.7	-1.9	-1.2	-1.8	-1.0	-1.3	-0.3	-1.7
Medication: Ibuprofen	1.5	1.8	4.4	-1.9	-1.3	-1.5	-1.3	-1.3	-1.1	-2.1	-0.1	-1.2
Family relationship satisfaction	1.5	1.9	4.4	-1.2	-1.6	-2.1	-1.1	-2.0	-0.9	-0.6	-0.9	-1.7
Unable to work because of sickness or disability	1.5	2.0	4.7	1.6	0.8	0.8	2.2	1.6	2.0	1.6	0.9	1.2
Severe depression (siblings)	1.4	1.6	2.9	-1.1	-1.6	-1.6	-1.1	-1.7	-0.6	-0.3	-1.6	-1.6
Had menopause	1.4	1.8	4.5	2.1	1.0	1.0	1.7	1.2	2.0	0.9	0.7	1.3
Alcohol intake versus 10 years previously	1.4	2.0	3.6	1.5	1.3	1.2	1.9	1.7	1.6	1.2	1.4	1.4
Prospective memory result	1.4	1.7	2.7	1.2	1.4	1.4	1.6	1.6	1.4	1.0	1.1	1.5
Medication: Seretide 50 evohaler	1.4	1.6	2.6	0.7	1.5	1.5	1.4	1.6	0.5	1.4	1.3	1.6
Guilty feelings	1.4	2.2	4.4	-1.2	-1.6	-2.0	-1.2	-1.8	-0.8	-1.1	-2.1	-1.6
Financial situation satisfaction	1.4	1.8	4.5	2.1	0.8	1.4	1.3	1.2	1.6	1.5	1.1	1.3
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.4	2.0	0.9	1.0	1.9	1.5	2.1	-0.1	1.0	1.2
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.9	1.5	1.4	1.0	1.5	1.7	1.6	1.1	0.2	1.6
Birth weight of first child	1.3	2.3	6.4	-1.0	-1.7	-0.6	-1.9	-1.8	-1.2	-0.4	-2.5	-2.0
Medication: Blood pressure	1.3	2.5	3.7	-1.7	-1.4	-1.5	-1.8	-1.9	-1.6	-1.6	-1.9	-1.6
Reaction Time	1.2	2.3	4.1	-1.7	-1.9	-2.0	-1.2	-1.8	-1.9	-0.7	-0.5	-1.8
Systolic Blood Pressure	1.2	6.0	9.5	2.5	3.1	3.0	2.3	2.8	3.0	2.1	0.3	2.9
Medication: Co-codamol	1.2	1.4	2.2	1.1	1.3	0.8	1.0	1.3	1.4	1.0	1.5	1.4
Body mass index (BMI)	1.2	4.9	7.5	2.4	2.0	2.4	2.3	2.2	2.3	2.7	2.3	2.3
Pulse wave reflection index	1.2	1.5	3.4	-1.4	-0.9	-1.4	-1.5	-1.4	-1.1	-0.6	-1.9	-1.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	5.4	-0.9	-0.9	-0.6	-1.7	-1.1	-0.5	-2.3	-1.3	-1.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	3.3	-1.3	-1.4	-1.8	-0.8	-1.2	-0.6	-1.8	-0.9	-1.3
Systolic blood pressure, automated reading	1.1	3.2	7.1	1.9	2.1	1.9	1.9	1.9	2.7	1.3	0.7	1.9
Emphysema/chronic bronchitis	1.1	1.3	4.4	0.6	1.4	1.5	0.4	1.0	0.2	2.1	1.2	1.2
Suffer from ‘nerves’	1.1	1.7	2.3	1.4	1.3	1.3	1.5	1.4	1.3	1.5	1.0	1.3
Ever smoked	1.1	1.9	3.3	1.3	1.5	1.3	1.7	1.8	1.8	1.1	-0.5	1.6
Age started oral contraceptive pill	1.1	1.3	2.1	-1.3	-1.1	-1.4	-1.2	-1.3	-1.4	-0.5	1.3	-1.2
Commuting to job workplace: Cycle	1.1	1.3	4.1	-1.4	-1.1	-0.9	-1.6	-1.0	-2.0	-0.3	-0.7	-1.2
Smoking Status	1.0	2.4	3.8	1.5	1.7	1.9	1.9	1.8	1.8	1.3	0.2	1.7
Sensitivity / hurt feelings	1.0	1.7	2.7	1.4	1.6	1.4	1.4	1.6	1.5	1.0	-0.0	1.6
Hayfever, allergic rhinitis or eczema	1.0	2.1	9.0	0.5	1.5	0.8	1.5	1.2	1.2	1.0	3.0	1.6
Leg pain on walking	1.0	1.2	2.2	0.7	1.1	0.8	1.4	1.4	1.5	1.0	0.9	1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.1	-0.9	-1.2	-0.6	-1.4	-1.3	-1.4	-0.6	-1.3	-1.3
Long-standing illness, disability or infirmity	1.0	1.5	3.9	-2.0	-1.1	-1.9	-0.7	-1.0	-0.5	-1.6	-0.8	-1.0
Osteoporosis (self-reported)	1.0	1.2	2.8	0.8	1.1	0.8	1.7	1.3	1.4	0.9	1.0	1.3
Wears glasses or contact lenses	1.0	1.1	2.7	-1.2	-1.1	-1.6	-1.3	-1.3	-0.9	-0.6	0.2	-1.3
Age at First Birth	0.9	1.3	3.1	-0.2	-1.3	-0.7	-1.8	-1.3	-1.1	-1.0	-0.8	-1.6
Blood Eosinophil Count	0.9	6.9	13.5	2.5	3.0	3.3	2.5	2.6	2.8	1.6	3.7	2.5
Blood Red Count	0.9	8.6	36.7	-6.1	2.8	-4.7	0.5	0.4	0.0	3.1	1.7	2.5
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.0	-1.2	-0.9	-0.6	-1.5	-1.1	-1.7	-0.8	-1.1	-1.2
Father’s age at death	0.9	1.2	2.7	0.7	1.3	1.1	1.1	1.1	1.3	0.4	1.6	1.2
Happiness	0.9	1.1	2.4	-0.9	-1.4	-1.5	-1.0	-1.2	-0.4	-1.3	-0.2	-1.4
Medication: Omeprazole	0.9	1.1	2.0	1.1	1.0	0.5	1.4	1.2	1.4	1.0	0.6	1.3
Pulse rate, automated reading	0.9	2.9	11.6	0.4	-1.9	0.4	-1.5	-1.8	-2.1	3.4	-0.2	-1.9
Back pain experienced in last month	0.9	1.2	2.8	1.5	1.0	0.6	1.0	1.1	1.5	0.5	1.7	1.3
Heart disease (siblings)	0.9	1.1	3.6	-1.0	-0.6	-0.0	-1.9	-0.9	-1.6	0.5	-1.2	-0.7
Schizophrenia vs Biploar Disorder	0.8	1.0	2.9	-1.7	-1.2	-1.4	0.3	-0.5	-1.0	-0.2	-1.4	-0.8
BMI	0.8	4.5	11.1	1.2	1.5	1.4	2.3	1.9	2.1	3.3	3.3	2.0
Hearing difficulty/problems with background noise	0.8	1.3	3.8	-1.9	-1.2	-1.1	-0.9	-1.1	-1.9	-0.2	-0.2	-1.1
Allergy	0.8	1.9	5.5	-0.1	-1.8	-1.0	-1.4	-1.5	-0.6	-1.1	-2.4	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	5.4	-1.0	-0.4	-1.4	-0.4	-0.4	-0.0	-2.3	-0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	-1.0	-1.3	-1.4	-1.0	-1.0	-1.0	-1.0	-1.3	-1.2
Hair/balding pattern: Pattern 4	0.8	2.0	5.6	-1.4	-1.7	-2.4	-1.6	-1.7	-1.1	-0.3	0.3	-1.6
Medication: Allopurinol	0.8	1.0	4.5	0.9	0.6	0.7	0.9	0.7	1.0	2.1	1.2	0.5
Mean time to correctly identify matches	0.8	1.5	3.2	-1.3	-1.6	-1.8	-0.9	-1.4	-1.4	-0.9	-0.6	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	1.3	0.9	0.7	1.1	1.2	1.4	-0.5	0.5	1.0
Leg fat-free mass (right)	0.8	4.3	9.1	2.0	2.1	3.0	2.0	2.3	1.2	3.0	1.3	2.1
Leg predicted mass (right)	0.8	4.4	9.3	2.0	2.1	3.0	2.0	2.4	1.2	3.0	1.3	2.1
Eye problems/disorders: Glaucoma	0.8	0.9	2.2	0.5	1.3	1.2	0.3	1.0	0.8	0.6	1.5	1.1
Fractured/broken bones in last 5 years	0.8	1.1	2.8	1.4	1.0	1.1	1.2	0.9	1.7	0.8	-0.0	1.0
Schizophrenia (2018)	0.7	1.5	3.3	-1.2	-1.5	-1.7	-1.2	-1.8	-0.9	-0.7	-0.1	-1.4
Crohns Disease (2012)	0.7	1.1	3.4	-1.0	-1.0	-0.8	-1.4	-1.2	-0.6	-1.8	-0.4	-1.2
HbA1C	0.7	0.7	1.5	0.7	0.7	0.3	1.1	0.9	1.1	-1.0	1.2	0.6
Lung FEV1/FVC ratio	0.7	3.7	13.0	3.0	0.9	2.0	2.2	1.5	3.6	1.1	0.2	1.1
Supplements: Zinc	0.7	0.7	2.2	-1.3	-0.5	-0.7	-1.0	-0.6	-1.5	-0.8	-0.0	-0.8
Leg fat-free mass (left)	0.7	3.7	8.5	1.9	1.8	2.7	1.9	2.1	1.1	2.9	1.3	1.9
Supplements: Glucosamine	0.7	0.9	2.5	-1.1	-1.2	-1.6	-0.0	-0.9	-0.7	-0.8	1.1	-0.9
Leg predicted mass (left)	0.7	3.6	8.4	1.9	1.8	2.7	1.8	2.1	1.1	2.9	1.2	1.9
Worrier / anxious feelings	0.7	1.3	2.0	-1.3	-1.1	-1.4	-1.3	-1.2	-1.4	-0.8	-0.7	-1.3
Noisy workplace	0.7	0.9	1.9	0.9	0.5	1.1	1.2	0.8	1.4	1.3	0.7	0.6
Neck or shoulder pain in last month	0.7	1.0	3.1	0.5	0.9	0.5	1.5	1.5	0.3	-0.5	1.8	1.0
Ever taken oral contraceptive pill	0.7	0.8	1.9	-1.1	-0.7	-1.2	-0.3	-0.7	-1.1	-1.4	-0.7	-0.7
High cholesterol (Self-reported)	0.7	1.2	2.5	-0.9	-1.2	-1.5	-1.4	-1.6	-0.8	0.8	-0.9	-1.1
Number of operations (self-reported)	0.7	1.0	2.1	1.3	0.8	0.1	1.4	1.2	1.5	0.3	1.2	1.0
Alzheimer’s Disease (in father)	0.6	0.7	2.1	1.0	0.8	0.8	0.8	0.7	1.4	-0.2	-0.5	0.9
Lupus	0.6	0.8	2.1	0.9	0.8	0.6	1.5	0.9	1.2	0.6	0.6	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.3	0.3	0.9	0.4	1.5	1.3	0.9	-0.4	1.1	0.0
Ever had hysterectomy (womb removed)	0.6	0.6	1.3	1.0	0.7	0.8	1.1	1.1	1.1	-0.1	0.3	0.8
Average weekly fortified wine intake	0.6	0.7	1.9	-1.3	-0.8	-1.4	-0.2	-0.9	-0.5	-0.9	-0.6	-0.5
Pulse rate	0.6	1.1	6.9	1.4	0.2	1.2	0.4	0.2	0.0	2.6	0.4	0.3
Arm fat mass (right)	0.6	2.4	4.8	1.6	1.4	2.0	1.5	1.4	1.3	2.2	1.4	1.6
Standing height	0.6	6.2	13.8	-2.9	-2.3	-1.6	-2.6	-2.5	-3.7	-0.8	-3.5	-2.5
Breastfed as a baby	0.6	0.7	2.0	0.0	0.9	0.4	0.4	0.8	0.9	1.4	1.2	0.9
Medication: Aspirin	0.6	0.8	2.3	-0.4	-0.7	-0.8	-1.4	-0.9	-0.3	-1.1	-1.5	-0.8
Medication: Aspirin	0.6	0.7	2.3	-0.1	-0.6	-0.4	-1.4	-0.7	-0.0	-1.2	-1.5	-0.7
Miserableness	0.6	1.0	2.3	-0.9	-0.6	-0.8	-1.5	-0.8	-1.3	-1.2	-1.1	-0.9
Medication: Bendroflumethiazide	0.6	0.9	2.0	-1.2	-0.8	-0.7	-0.7	-1.0	-1.4	0.4	-1.3	-0.8
Medication: Lisinopril	0.6	0.7	2.2	-1.5	-0.5	-0.9	-0.4	-0.8	-1.4	0.8	-0.5	-0.6
Diastolic blood pressure, automated reading	0.6	1.8	8.7	1.3	1.2	1.4	0.3	0.6	1.4	2.9	0.6	1.0
Ever depressed for a whole week	0.6	0.7	1.8	1.4	0.9	0.9	0.8	1.2	1.1	0.5	0.2	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	0.4	1.2	1.0	0.6	0.7	0.7	1.0	1.1	1.1
Bipolar Disorder (2018)	0.5	0.8	2.6	1.4	0.8	0.5	0.1	0.7	0.9	0.4	1.6	0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	3.2	0.3	0.0	-0.0	0.3	-0.2	1.3	-1.8	-1.4	0.2
LDL Cholesterol	0.5	0.7	2.1	-1.4	-1.0	-0.9	-0.4	-0.8	-1.4	0.5	-0.4	0.0
Height	0.5	9.1	19.9	-3.1	-2.7	-1.3	-3.5	-3.1	-4.5	-0.6	-4.5	-3.2
Allergy or Eczema	0.5	1.2	8.9	0.1	0.8	0.2	0.9	0.6	0.4	0.6	3.0	0.9
Hypothyroidism (self reported)	0.5	1.1	2.9	-1.3	-0.7	-1.4	-0.2	-0.7	-0.9	-1.6	-1.7	-0.8
Respiratory disease	0.5	1.1	5.7	-2.0	-0.2	-0.6	-0.9	-0.5	-2.4	0.2	-0.3	-0.4
Average weekly spirits intake	0.5	0.6	2.8	1.0	0.2	0.3	1.1	0.5	1.7	0.8	0.2	0.6
Taking other prescription medications	0.5	0.8	3.4	-1.0	-0.5	-1.5	-0.0	-0.4	-0.1	-1.9	-0.8	-0.5
Age when periods started (menarche)	0.5	1.3	3.2	-0.6	-1.3	-0.3	-1.3	-1.2	-1.8	0.0	-1.7	-1.3
Multivitamins +/- minerals	0.5	0.6	2.8	-0.2	-0.1	-0.0	1.0	0.5	-0.4	1.7	1.4	0.1
Past tobacco smoking	0.5	0.9	2.0	-0.8	-1.0	-1.1	-0.9	-1.2	-1.4	-0.4	0.9	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	3.1	1.8	0.4	1.0	0.2	0.5	1.2	0.3	-0.2	0.2
Mouth/teeth dental problems	0.5	0.7	1.5	0.3	0.8	0.9	1.1	0.7	0.1	1.2	1.1	1.0
Medication: Lansoprazole	0.5	0.6	2.2	1.3	0.6	0.8	0.0	0.4	1.5	-0.5	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.5	1.6	0.8	1.9	1.4	1.1	0.4	1.8	-0.8	0.9
Medication: Paracetamol	0.5	0.9	3.9	-0.0	0.9	0.6	1.0	0.9	0.3	1.0	2.0	1.0
Gout (self-reported)	0.5	0.6	2.0	0.7	0.5	0.7	0.9	0.6	1.0	1.4	0.8	0.4
Supplements: Vitamin C	0.5	0.6	2.3	-1.4	-0.2	-0.2	-0.6	-0.5	-1.5	-0.1	0.9	-0.3
Illnesses of father: Heart disease	0.5	0.6	1.6	-0.6	-0.8	-1.0	-1.3	-0.9	-0.7	-0.2	-1.0	-0.6
Ever had bowel cancer screening	0.5	0.5	1.4	-0.9	-1.2	-1.0	-0.1	-0.5	-0.5	-0.9	-0.3	-0.9
Osteoarthritis (self-reported)	0.5	0.6	2.3	-1.0	-0.8	-1.3	0.1	-0.3	-0.1	-1.5	-0.3	-0.6
Depression (Nagel 2018)	0.4	0.6	1.9	-0.3	-0.7	-0.5	-1.4	-1.0	-1.0	-1.0	-0.2	-0.9
Fasting Glucose	0.4	0.5	0.8	0.6	0.7	0.6	0.9	0.8	0.1	-0.8	-0.9	0.8
HDL Cholesterol	0.4	0.7	3.1	0.3	0.5	0.4	0.8	0.8	-0.0	1.5	1.8	0.0
Rheumatoid Arthritis	0.4	0.6	1.9	1.4	0.1	0.2	1.2	0.6	1.1	-0.5	-0.5	0.4
Ulcerative Colitis	0.4	0.5	1.7	0.0	-1.3	-0.2	-0.5	-0.7	-0.6	0.4	1.0	-1.2
Waist Hip Ratio (WHR)	0.4	1.7	8.0	-1.5	-0.6	-0.4	-1.3	-1.2	-1.4	-0.2	-2.8	-1.1
Chronotype (morning person)	0.4	1.0	1.8	-1.1	-1.2	-1.3	-1.3	-0.9	-1.4	-0.6	0.1	-1.2
Current tobacco smoking	0.4	0.7	1.4	1.0	0.9	0.7	1.2	1.0	1.0	0.3	0.4	1.1
Maternal smoking around birth	0.4	0.6	1.5	1.0	0.5	0.8	0.9	0.9	1.2	0.7	0.7	0.6
Medication: Atenolol	0.4	0.5	1.5	1.2	1.0	1.2	-0.0	0.6	0.4	0.0	-0.1	0.7
Medication: Simvastatin	0.4	0.6	1.2	-0.8	-0.9	-1.0	-0.7	-1.1	-0.8	0.6	-0.6	-0.8
Pulse wave Arterial Stiffness index	0.4	0.4	3.5	-0.2	-0.3	-0.6	0.2	-0.2	0.2	1.9	-0.4	0.0
Loud music exposure frequency	0.4	0.5	0.8	0.4	0.8	0.6	0.7	0.9	0.5	0.9	0.5	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	2.5	0.6	-0.3	-0.2	-0.2	-0.1	0.2	1.6	1.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.4	-0.4	-0.9	-0.1	-1.2	-0.8	-0.8	-0.4	-0.8	-1.1
Pulse wave peak to peak time	0.4	0.4	3.6	0.2	0.1	0.6	-0.3	0.1	-0.3	-1.9	0.1	-0.1
Whole body fat-free mass	0.4	2.2	5.5	1.7	1.3	2.3	1.3	1.6	0.6	2.3	0.7	1.4
Smoking status: Current	0.4	0.6	1.3	0.9	0.9	0.7	1.1	1.0	0.7	-0.0	0.1	1.1
Whole body water mass	0.4	2.3	5.9	1.7	1.3	2.4	1.4	1.6	0.6	2.3	0.7	1.4
Arm fat mass (left)	0.4	1.6	3.9	1.2	1.1	1.6	1.3	1.1	0.9	2.0	1.3	1.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	-0.7	-0.8	-1.2	-0.4	-0.8	-0.0	-1.4	-1.1	-0.7
Medication: Atorvastatin	0.4	0.5	1.3	0.1	-0.9	-0.9	-1.2	-0.8	-0.4	0.1	0.3	-0.8
Basal metabolic rate	0.4	2.1	5.6	1.6	1.2	2.3	1.3	1.5	0.5	2.4	0.8	1.3
Arm fat-free mass (left)	0.4	2.0	6.1	1.5	1.0	2.3	1.0	1.3	0.5	2.5	1.0	1.1
Arm predicted mass (left)	0.4	2.0	5.8	1.6	1.0	2.3	1.0	1.3	0.6	2.4	1.1	1.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.2	-0.3	-0.4	-0.4	-0.3	-0.8	0.6	-1.1	-1.0	-0.3
Irritable Bowel Disease (IBD)	0.3	0.6	1.8	-0.4	-0.9	-0.0	-1.4	-1.1	-1.0	-0.2	1.0	0.0
Ulcerative Colitis (UC)	0.3	0.5	1.5	0.1	-1.2	-0.2	-1.1	-1.2	-0.7	-0.4	0.3	0.0
Ovarian Cancer	0.3	0.4	1.0	-0.9	-0.5	-0.7	-1.0	-0.7	-0.8	-0.1	-0.7	-0.4
Schizophrenia (2014)	0.3	0.7	1.6	-0.6	-1.1	-1.0	-0.9	-1.3	-0.6	-0.2	0.2	-1.1
Cardiovascular Disease	0.3	0.9	1.8	-1.1	-0.6	-0.7	-0.9	-1.2	-1.0	1.4	-1.0	-0.8
Tanning	0.3	3.7	5.8	2.0	2.0	2.0	2.3	2.4	2.1	1.4	1.7	2.2
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-0.7	-0.6	-0.3	-0.6	-0.4	-1.1	0.1	-0.9	-0.6
Vitamin and mineral supplements	0.3	0.4	1.8	-0.1	0.0	-0.2	-0.8	-0.5	0.2	-1.0	-1.3	-0.3
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.7	0.6	0.7	-0.2	0.4	0.9	0.9	0.5	0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.2	0.5	0.4	0.8	1.1	0.7	-0.3	0.7	0.9	0.4
Stomach or abdominal pain in last month	0.3	0.3	1.2	-0.5	0.1	-0.7	0.5	0.4	0.6	-1.1	-0.8	0.2
Medication: Levothyroxine sodium	0.3	0.4	2.0	-0.0	-0.7	-1.1	-0.1	-0.5	0.3	-1.4	-0.6	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.3	0.2	-0.1	0.9	0.5	-0.3	1.0	-0.4	0.6
Arm fat percentage (right)	0.3	1.0	1.5	0.9	1.0	1.1	1.2	1.0	1.0	1.2	1.1	1.2
Time employed in main current job	0.3	0.4	0.9	-0.7	-0.6	-0.7	-0.9	-0.7	-0.7	-0.2	-0.4	-0.6
Falls in the last year	0.3	0.4	1.3	0.8	0.0	-0.0	0.8	0.2	1.1	-1.2	-0.2	0.3
Hair/balding pattern: Pattern 3	0.3	0.5	2.9	-0.4	0.4	-0.1	0.6	0.5	0.3	-1.7	-0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.9	1.2	0.5	1.7	0.9	0.7	-0.2	1.4	-1.0	0.7
Trunk predicted mass	0.3	1.4	4.0	1.5	0.9	2.0	1.0	1.2	0.3	1.9	0.5	1.0
Headache pain in last month	0.3	0.5	2.6	-0.8	-0.5	-0.5	0.0	-0.3	-0.6	-1.6	-0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	3.2	-0.4	-0.3	-1.0	0.2	-0.2	-0.1	-1.8	-1.5	-0.2
Arm fat-free mass (right)	0.3	1.7	5.0	1.5	0.8	2.1	1.0	1.2	0.4	2.2	0.8	1.1
Worry too long after embarrassment	0.3	0.5	0.8	-0.9	-0.6	-0.8	-0.9	-0.8	-0.8	0.4	-0.3	-0.7
Shortness of breath walking on level ground	0.3	0.3	0.9	0.4	0.4	0.8	0.4	0.6	0.1	0.8	0.9	0.5
Eye problems/disorders: None of the above	0.3	0.4	1.5	0.6	0.5	0.7	0.6	0.6	0.4	-0.2	-1.2	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	1.1	0.6	0.9	0.8	0.7	0.5	0.8	0.3	0.4
Angina (self-reported)	0.3	0.4	0.9	0.6	0.8	0.1	0.6	0.8	0.9	0.4	0.7	0.8
Migraine (self-reported)	0.3	0.4	1.0	-1.0	-0.7	-0.6	-0.6	-0.6	-0.7	-0.7	0.1	-0.8
Arm predicted mass (right)	0.3	1.4	4.8	1.3	0.7	1.9	0.8	1.0	0.2	2.2	0.8	0.9
Had major operations	0.3	0.3	1.4	0.2	-0.0	-0.6	0.8	0.3	0.3	0.7	1.2	0.2
Smoking status: Previous	0.3	0.5	1.6	0.3	0.7	0.8	0.4	0.7	1.3	0.2	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.2	0.9	0.3	1.1	0.7	0.8	-0.6	1.5	-0.7	0.2
Mood swings	0.3	0.5	1.0	0.7	0.9	0.7	0.5	1.0	0.1	0.9	0.8	0.8
Eye problems/disorders: Cataract	0.3	0.4	1.5	-1.0	-0.4	-0.3	-0.6	-0.5	-1.2	0.3	0.1	-0.5
Mother’s age at death	0.3	0.3	2.4	-0.3	0.4	-0.3	-0.5	0.1	-0.5	-1.6	0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.0	0.2	0.3	-0.3	0.8	0.5	0.9	0.3	1.4	0.3
Irritability	0.3	0.5	1.3	0.5	1.1	0.3	0.7	1.0	0.7	0.1	0.5	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.9	0.3	0.1	-0.1	-0.6	-0.0	-0.1	-1.4	-1.1	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.2	-0.1	-0.7	-1.1	-0.9	-1.0	-0.2	-0.3	0.9	-0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.4	-1.1	-0.4	-1.2	-0.4	-0.5	-0.7	0.1	0.0	-0.5
Crohns Disease (2017)	0.2	0.5	1.4	-0.9	-0.6	-0.4	-1.2	-0.9	-1.0	-0.8	0.4	0.0
Neuroticism (2016)	0.2	0.2	0.7	0.8	0.5	0.7	0.2	0.5	-0.4	0.7	-0.3	0.3
Angina	0.2	0.3	0.6	0.3	0.7	-0.0	0.5	0.7	0.7	0.5	0.7	0.7
Diabetes (father)	0.2	0.3	0.7	0.3	0.7	0.3	0.8	0.6	0.5	0.1	0.6	0.7
Pack years adult smoking proportion	0.2	0.3	1.6	-0.9	-0.1	-0.1	-0.4	-0.3	-0.9	-0.2	1.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	0.1	-0.4	-0.1	-1.0	-0.6	-0.8	-0.3	0.1	-0.5
High blood pressure (mother)	0.2	0.3	0.9	0.6	0.7	0.9	0.7	0.6	-0.5	0.3	0.1	0.6
Waist circumference	0.2	0.7	1.6	0.9	0.8	1.3	0.9	0.8	0.7	1.1	0.4	1.0
Forced vital capacity (FVC)	0.2	0.9	4.5	-0.3	-0.6	0.3	-0.5	-0.6	-2.1	0.7	-1.7	-0.6
Heart attack	0.2	0.3	1.4	0.4	0.3	0.0	-0.4	0.2	0.0	-1.2	-1.0	0.2
Pain all over the body in last month	0.2	0.3	1.6	0.2	-0.4	-0.2	-0.2	-0.1	-0.6	-0.4	-1.3	-0.4
Diabetes (self-reported)	0.2	0.3	1.0	0.3	0.3	-0.0	0.8	0.5	0.4	1.0	0.7	0.7
Weight	0.2	1.2	4.3	0.9	0.8	1.6	1.0	1.0	0.4	2.1	0.6	1.0
Trunk fat-free mass	0.2	1.4	4.1	1.5	0.9	2.0	1.0	1.2	0.3	1.8	0.4	1.0
Hip circumference	0.2	0.8	1.3	0.9	0.6	1.1	1.1	0.9	0.5	1.1	0.9	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.6	-0.4	-0.1	-0.4	-0.3	-1.0	-0.5	-0.8	-0.4
Number of live births	0.2	0.3	1.9	-0.1	-0.4	-0.5	-0.2	-0.0	-0.3	-1.4	-0.3	-0.3
Asthma	0.2	0.5	2.4	-1.5	0.1	-0.3	-0.1	-0.1	-1.5	0.3	-0.4	0.1
Depression (self-reported)	0.2	0.2	0.9	-0.3	-0.6	-0.5	-0.3	-0.4	-0.2	-0.2	-0.9	-0.5
Tense / ‘highly strung’	0.2	0.4	1.1	-0.7	-0.5	-0.6	-0.7	-0.2	-0.9	-1.1	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.8	-0.4	-0.9	-0.3	-0.6	-0.5	0.2	-0.0	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	2.4	0.2	0.1	0.4	0.0	0.2	0.6	-1.6	0.0	-0.0
Medication: Amlodipine	0.2	0.2	0.4	-0.6	-0.6	-0.6	-0.2	-0.6	-0.3	0.4	-0.5	-0.6
Birth weight	0.2	0.4	2.0	0.1	-0.2	0.3	-0.3	0.1	-1.0	1.4	-0.6	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	2.0	0.4	0.0	1.0	0.2	0.2	-1.3	1.4	-1.2	0.0
Number of full brothers	0.2	0.2	0.6	0.3	0.5	0.7	-0.7	-0.1	-0.1	-0.6	0.4	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.4	0.7	0.6	0.3	0.8	-0.4	0.9	0.9	0.7
Health satisfaction	0.2	0.2	0.6	0.4	-0.1	-0.2	0.6	0.3	0.8	-0.7	-0.7	0.2
Medication: Blood pressure	0.2	0.3	1.6	-0.6	-0.3	-0.6	-0.3	-0.4	-0.8	1.3	-0.3	-0.3
Whole body fat mass	0.2	0.7	3.2	0.6	0.5	0.9	0.9	0.6	0.5	1.8	0.7	0.8
Leg fat mass (right)	0.2	0.6	3.1	0.7	0.3	0.8	0.5	0.3	0.6	1.8	1.0	0.6
Overall health rating	0.2	0.5	1.4	1.1	0.4	0.6	0.7	0.7	1.2	-0.3	-0.5	0.5
Hypertension (Self-reported)	0.2	0.5	1.1	-0.8	-0.4	-0.6	-0.5	-0.8	-0.9	0.5	-1.1	-0.4
Arm fat percentage (left)	0.2	0.9	1.5	0.7	0.8	0.9	1.1	0.8	0.8	1.2	1.1	1.1
Loneliness, isolation	0.2	0.3	1.6	-0.1	0.0	-0.4	0.3	0.0	0.0	0.8	1.3	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.3	0.0	0.1	-0.6	0.5	0.3	0.4	-1.2	0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.2	-0.6	-0.5	-0.2	-0.2	-0.6
Mineral and other dietary supplements	0.2	0.3	1.0	-0.5	0.1	0.2	-0.7	-0.4	-1.0	0.6	-0.8	-0.1
Asthma (self-reported)	0.2	0.4	1.8	-1.3	0.1	-0.3	-0.1	-0.0	-1.3	0.4	-0.0	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.1	-0.6	-0.4	-0.3	-0.6	-0.5	0.6	-0.4	-0.6
Alcohol drinker status: Never	0.2	0.3	0.7	-0.5	-0.1	-0.8	0.6	0.3	0.7	-0.6	0.7	0.2
Pack years of smoking	0.2	0.2	1.6	-0.4	0.1	0.1	-0.0	0.1	-0.6	-0.3	1.3	0.2
Leg fat mass (left)	0.2	0.9	4.1	0.8	0.5	1.0	0.6	0.5	0.6	2.0	1.1	0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.6	-0.2	-0.7	-0.2	-0.2	-0.7	0.0	0.5	-0.3
Major Depression (MDD)	0.1	0.1	0.3	0.4	-0.3	-0.5	0.5	-0.3	0.4	0.4	0.5	-0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.6	-0.3	-0.2	-0.2	-0.6	-0.3	-0.7	-0.1	0.8	0.0
Coronary Artery Disease (CAD)	0.1	0.1	1.0	-0.1	-0.2	0.1	-0.2	-0.2	0.1	1.0	0.3	0.0
Triglycerides	0.1	0.2	0.4	-0.6	-0.2	-0.2	-0.6	-0.6	-0.6	0.2	-0.2	0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	-0.6	-0.2	-0.8	0.6	-0.0	-0.3	0.6	0.1	0.2
Lung FVC	0.1	0.6	2.0	1.4	0.6	1.1	0.4	0.6	-0.5	0.5	-0.5	0.9
Hair Pigment	0.1	2.8	7.1	1.5	1.6	2.3	1.7	1.7	1.1	0.5	-2.7	1.8
Number of treatments/medications taken	0.1	0.1	0.4	-0.0	0.5	-0.0	0.5	0.3	0.2	0.1	0.6	0.6
Relative age of first facial hair	0.1	0.2	0.4	0.2	-0.6	0.0	-0.6	-0.4	-0.4	0.2	-0.5	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.1	-0.4	-0.2	0.1	0.0	0.5	0.7	-0.3	-0.5
Medication: Metformin	0.1	0.1	0.3	0.3	-0.0	0.1	0.5	0.5	0.0	-0.1	0.0	0.3
Relative age voice broke	0.1	0.2	0.6	0.1	-0.8	-0.3	-0.2	-0.4	-0.6	0.6	0.6	-0.4
High blood pressure	0.1	0.2	1.2	-0.3	-0.1	-0.3	-0.2	-0.4	-0.4	0.8	-1.1	-0.1
Sitting height	0.1	1.0	3.5	-1.2	-0.8	-0.4	-1.0	-0.8	-1.4	-0.1	-1.9	-1.1
Alcohol usually taken with meals	0.1	0.2	1.2	-1.1	-0.3	-0.6	-0.2	-0.1	-0.6	-0.3	-0.1	-0.2
Nervous feelings	0.1	0.2	0.9	0.2	1.0	0.3	0.4	0.6	0.4	0.2	-0.5	0.7
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.2	-0.2	-0.6	0.4	0.1	-0.2	0.5	-0.1	-0.0
Medication: Ramipril	0.1	0.1	0.5	0.2	0.2	0.0	0.7	0.3	0.1	-0.7	-0.5	0.4
Neuroticism score	0.1	0.1	0.3	0.1	0.6	0.1	0.3	0.5	-0.1	0.3	0.3	0.5
Medication: Cholesterol lowering	0.1	0.2	2.1	0.4	0.1	-0.1	-0.1	-0.1	-0.1	1.4	-0.0	0.2
Illnesses of mother	0.1	0.1	0.3	0.2	0.4	-0.4	-0.0	0.3	0.5	-0.1	0.1	0.3
Length of working week for main job	0.1	0.2	0.4	0.5	-0.4	0.3	-0.6	-0.2	0.1	0.4	-0.6	-0.4
Peak expiratory flow (PEF)	0.1	0.2	1.0	0.2	-0.2	0.7	0.0	0.0	-0.0	0.6	-1.0	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	0.6	0.2	0.3	0.6	0.3	0.7	0.1	0.4	0.2
Glaucoma (self-reported)	0.1	0.2	0.3	-0.1	0.6	0.6	-0.2	0.3	0.5	-0.4	0.4	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	-0.5	0.2	0.5	-0.7	-0.0	-0.9	-0.2	-0.1	-0.2
Leg fat percentage (right)	0.1	0.2	0.6	-0.1	-0.6	-0.4	-0.4	-0.6	-0.1	0.8	0.7	-0.2
Comparative height size at age 10	0.1	0.6	1.5	0.6	0.9	1.2	0.8	0.8	0.5	0.1	-0.9	1.0
Number of full sisters	0.1	0.1	0.5	0.1	0.1	0.2	-0.1	0.2	-0.3	0.7	-0.2	0.0
Chest pain or discomfort	0.1	0.2	0.5	-0.1	0.5	-0.1	0.4	0.7	0.1	0.4	0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.7	0.3	0.3	0.2	0.5	0.4	0.8	-0.3	0.1	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.7	0.4	-0.1	-0.8	0.4	-0.0	0.3	-0.2	0.4	0.3
Diabetes diagnosed by doctor	0.1	0.1	0.6	0.1	0.1	-0.2	0.8	0.2	0.3	0.7	-0.0	0.4
Medication for cholesterol	0.1	0.2	0.8	-0.5	-0.3	-0.7	0.7	0.2	-0.1	-0.9	0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.4	0.6	0.0	0.6	0.6	0.1	-0.3	0.3	-0.1	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.5	-0.7	0.1	-0.2	0.2	-0.1	0.0	-0.0	0.7	-0.1
Leg fat percentage (left)	0.1	0.2	1.0	-0.1	-0.4	-0.2	-0.3	-0.5	-0.2	1.0	0.7	-0.1
Average weekly beer plus cider intake	0.1	0.1	0.3	0.3	0.2	0.5	-0.5	0.0	-0.5	0.2	-0.5	0.3
Myopia	0.1	0.1	0.6	0.3	0.2	0.6	-0.5	0.1	0.2	0.0	-0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	2.0	0.2	-0.1	0.1	0.1	0.4	0.4	-1.4	0.9	-0.1
Pain experienced in last month	0.1	0.2	0.5	-0.1	-0.3	-0.3	-0.6	-0.6	-0.1	0.5	-0.7	-0.5
Supplements: Calcium	0.1	0.1	0.4	0.2	-0.0	0.3	-0.0	0.2	-0.6	-0.1	-0.1	0.0
Worry (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.0	-0.5	-0.1	-0.1	0.1	-0.3	-0.0	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.1	0.2	-0.2	0.3	-0.2	0.3	0.4	-0.3	0.2	0.4	0.2
Trunk fat percentage	0.0	0.2	0.5	-0.7	-0.4	-0.4	-0.0	-0.5	-0.4	0.7	0.2	-0.1
Trunk fat mass	0.0	0.2	1.3	-0.2	-0.1	0.2	0.2	-0.2	-0.3	1.1	0.1	0.1
Body fat percentage	0.0	0.1	0.8	-0.3	-0.2	-0.1	0.2	-0.2	-0.1	0.9	0.5	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.2	0.4	0.1	0.3	0.3	0.3	-0.0	0.1	-0.4	0.2
Commuting to job workplace: Walk	0.0	0.0	0.1	0.1	0.1	0.1	0.3	0.1	-0.2	-0.3	0.1	0.0
Medication: Gliclazide	0.0	0.0	0.2	0.2	0.0	0.0	0.2	0.3	0.2	-0.2	-0.4	0.1

Hub : Genes

TSC22D4

Models

Trait associations