Hub : Genes

TSG101

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1498 0.0441 1.3e-05 0.064 NA 0.069 NA 0.069 9.1e-06 NA 4.1e-06 NA 4.1e-06
2 GTEx Cells EBV-transformed lymphocytes 0.4300 0.0830 1.4e-07 0.461 NA 0.397 NA 0.460 8.3e-17 NA 4.8e-14 NA 9.0e-17
3 GTEx Esophagus Mucosa 0.2550 0.0540 2.8e-09 0.264 NA 0.246 NA 0.266 8.3e-18 NA 1.5e-16 NA 6.3e-18
4 GTEx Heart Left Ventricle 0.1416 0.0445 3.4e-04 0.090 NA 0.093 NA 0.099 1.7e-05 NA 1.2e-05 NA 6.4e-06
5 GTEx Muscle Skeletal 0.2932 0.0428 0.0e+00 0.277 NA 0.250 NA 0.281 3.3e-27 NA 2.3e-24 NA 1.1e-27
6 GTEx Thyroid 0.0770 0.0320 7.3e-03 0.090 NA 0.088 NA 0.092 2.0e-07 NA 3.0e-07 NA 1.5e-07
7 TCGA Kidney Renal Papillary Cell Carcinoma 0.0690 0.0360 1.2e-03 0.073 0.063 0.056 NA 0.060 5.8e-05 0.00018 4.0e-04 NA 2.5e-04
8 TCGA Lung Squamous Cell Carcinoma 0.0293 0.0138 1.2e-04 0.031 0.030 0.035 NA 0.032 1.5e-04 0.00021 6.2e-05 NA 1.5e-04
9 TCGA Thyroid Carcinoma 0.0340 0.0190 1.3e-03 0.032 0.027 0.034 NA 0.027 3.7e-04 0.00110 2.8e-04 NA 1.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.8 1.2 1.8 -1.3 1.1 1.0 -1.0 -1.1 -1.1 -1.2 1.1 -0.8
Bipolar Disorder or Schizophrenia 0.2 0.4 1.2 -1.1 0.7 0.5 -0.5 -0.4 -0.6 -0.9 0.2 -0.5
Depressed Affect (Nagel 2018) 0.0 0.1 0.3 0.1 0.4 0.1 0.1 -0.3 -0.2 0.4 -0.5 -0.3
Depression (Nagel 2018) 1.9 2.9 4.4 -1.3 1.9 1.7 -1.7 -1.8 -1.7 -1.4 1.3 -2.1
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.7 0.6 -0.6 -0.7 0.6 0.7 0.6 0.2 -0.5 0.8
Neuroticism (Nagel 2018) 0.1 0.2 0.5 0.0 0.7 0.5 -0.2 -0.7 -0.5 0.1 -0.3 -0.1
Schizophrenia (2018) 0.0 0.1 0.3 -0.3 0.0 -0.3 0.1 0.4 0.2 -0.2 -0.6 0.1
Schizophrenia vs Biploar Disorder 2.3 3.1 5.4 1.2 -1.7 -1.7 2.2 1.8 1.7 1.8 -2.3 1.0
Worry (Nagel 2018) 0.1 0.3 0.8 -0.3 0.7 0.7 -0.4 -0.9 -0.7 -0.5 0.1 -0.1
Alzheimer’s Disease (in mother) 1.2 1.4 2.2 0.8 -1.0 -1.3 1.1 1.3 1.3 0.6 -1.3 1.5
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.4 -0.4 -0.4 0.2 0.3 0.4 0.8 -0.2 0.5
Alzheimer’s Disease (including proxy) 1.4 2.0 2.6 1.2 -1.2 -1.6 1.4 1.5 1.6 1.1 -1.4 1.5
Crohns Disease (2017) 0.6 1.2 3.1 0.7 -0.7 -1.0 1.6 0.8 1.0 1.3 -1.7 -0.2
Irritable Bowel Disease (IBD) 1.7 4.0 6.9 1.7 -1.7 -2.1 2.3 1.8 1.9 2.2 -2.6 1.4
Ulcerative Colitis (UC) 1.1 2.1 3.2 1.2 -1.3 -1.5 1.5 1.3 1.3 1.4 -1.8 1.5
Major Depression (MDD) 0.7 0.9 1.4 0.7 -1.0 -0.9 1.2 1.1 0.9 0.9 -1.1 0.4
Reaction Time 0.2 0.4 1.4 0.1 0.7 0.6 -0.7 -1.2 -0.6 -0.2 0.6 -0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.8 0.9 -0.7 -0.8 0.6 0.7 0.8 0.7 -0.4 0.8
Breast Cancer 4.8 11.7 15.4 -3.3 3.4 3.2 -3.1 -3.1 -3.3 -3.8 3.3 -3.9
Ovarian Cancer 1.5 2.0 2.5 1.6 -1.5 -1.4 1.5 1.2 1.5 1.3 -1.5 1.1
Prostate Cancer 0.9 1.2 1.9 -0.3 1.2 0.9 -1.4 -1.1 -1.0 -1.3 1.2 -1.2
Age at First Birth 0.1 0.1 0.2 -0.3 0.1 0.4 0.3 -0.4 -0.3 -0.3 -0.4 0.4
Bipolar Disorder (2011) 0.2 0.2 0.9 0.1 0.3 0.2 -0.8 -0.3 -0.2 -0.5 0.9 -0.1
Body Mass Index (BMI) (2010) 1.2 1.7 3.3 1.1 -1.3 -1.4 0.8 1.6 1.4 1.2 -0.9 1.8
Coronary Artery Disease (CAD) 2.0 2.4 4.3 2.1 -1.5 -1.7 1.6 1.3 1.5 2.0 -1.3 0.6
Crohns Disease (2012) 0.8 1.2 2.7 1.0 -0.8 -1.3 1.3 1.1 1.2 1.0 -1.6 0.3
Mean Putamen Volume 0.2 0.3 1.5 -0.8 0.2 0.1 0.1 0.0 -0.2 -0.2 -0.2 -1.2
Fasting Glucose 1.1 1.3 2.4 0.8 -1.3 -1.2 1.2 1.3 1.1 1.5 -1.0 0.6
HbA1C 0.8 0.9 3.5 0.5 -0.7 -0.5 0.9 0.5 0.8 1.0 -1.9 0.9
HDL Cholesterol 0.3 0.5 0.9 0.9 -0.5 -0.8 0.6 0.7 0.8 0.5 -0.7 0.4
LDL Cholesterol 5.0 8.0 11.6 3.4 -2.8 -2.6 3.0 2.4 2.7 2.7 -2.9 2.8
Lupus 0.1 0.2 0.8 0.2 0.1 -0.3 0.1 0.3 0.3 0.9 -0.3 -0.4
Neuroticism (2016) 1.0 1.4 2.5 0.9 -1.1 -1.0 1.3 1.0 1.0 1.6 -1.5 0.9
Primary Biliary Cirrhosis 0.3 0.4 2.3 -0.8 0.5 0.3 -0.3 -0.4 -0.3 -0.1 0.0 -1.5
Rheumatoid Arthritis 0.2 0.2 0.5 0.6 -0.4 -0.4 0.5 0.2 0.4 0.7 -0.5 0.1
Schizophrenia (2014) 0.1 0.1 0.5 -0.7 0.2 -0.2 0.1 0.3 -0.1 -0.1 -0.6 -0.3
Triglycerides 2.2 3.6 5.0 1.9 -2.1 -1.8 2.0 1.7 1.8 1.8 -1.8 2.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 -0.0 -0.4 -0.5 0.4 0.6 0.5 0.6 -0.7 -0.5
Ulcerative Colitis 1.4 2.0 3.4 1.1 -1.3 -1.5 1.4 1.4 1.2 1.5 -1.8 1.2
Blood Eosinophil Count 0.0 0.2 0.8 0.1 -0.2 0.4 -0.3 -0.2 -0.2 -0.1 0.6 -0.9
Blood Platelet Count 0.2 2.7 3.7 -1.0 1.9 1.6 -1.9 -1.8 -1.7 -1.5 1.7 -1.5
Blood Red Count 0.2 2.1 4.4 1.5 -1.5 -1.4 1.3 1.5 1.4 1.1 -1.1 2.1
Blood White Count 0.2 1.7 4.8 -0.5 1.4 1.1 -1.3 -1.1 -1.2 -2.2 1.7 -0.4
Heel T-Score 0.1 0.5 1.1 -1.0 0.9 0.8 -0.6 -0.7 -0.8 -0.3 0.0 -0.4
BMI 0.6 3.4 4.2 1.9 -1.8 -2.0 1.5 2.0 1.9 1.9 -1.6 1.8
Height 1.0 19.1 41.6 -5.4 3.9 4.1 -4.4 -3.6 -4.1 -2.5 3.7 -6.5
Waist Hip Ratio (WHR) 0.0 0.1 0.3 0.1 -0.1 0.2 0.4 -0.2 -0.2 -0.5 0.1 0.5
Systolic Blood Pressure 0.1 0.4 1.4 0.0 0.5 0.4 -0.7 -0.5 -0.5 -1.2 1.0 0.4
Smoking Status 0.0 0.1 0.2 0.3 0.0 -0.4 0.2 0.5 0.3 0.3 -0.4 0.2
Allergy or Eczema 0.0 0.1 0.5 0.7 -0.0 -0.1 0.1 -0.1 0.1 -0.4 -0.1 0.3
Cardiovascular Disease 0.3 1.1 2.0 1.4 -1.0 -0.9 1.0 0.7 0.9 1.0 -1.0 1.3
Hypothyroidism (self reported) 0.1 0.2 1.0 0.3 -0.1 0.0 -0.1 -0.0 0.0 1.0 -0.0 -0.8
Respiratory disease 0.4 0.9 1.1 1.0 -0.9 -0.9 1.0 1.0 0.9 1.1 -0.8 0.9
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.5 0.3 0.1 -0.5 0.1 0.3 0.4 -0.2 -0.2 0.7
Lung FEV1/FVC ratio 0.7 3.5 5.1 -2.3 1.9 1.8 -2.0 -1.8 -1.8 -2.0 2.1 -0.9
Lung FVC 0.1 0.5 1.7 0.3 -0.4 -0.4 0.7 0.4 0.4 1.3 -1.1 0.4
Neuroticism 0.1 0.3 1.1 0.7 0.1 -0.4 0.4 0.2 0.3 0.7 -1.0 0.1
Chronotype (morning person) 0.3 0.6 1.3 0.0 0.8 0.7 -1.1 -0.7 -0.7 -0.1 1.0 -1.1
Hair Pigment 0.0 0.3 1.4 1.2 -0.1 -0.4 0.1 0.1 0.3 0.8 -0.5 0.1
Tanning 0.0 0.4 0.8 -0.9 0.7 0.5 -0.8 -0.6 -0.5 -0.8 0.4 0.4
Hand grip strength (left) 1.0 2.6 6.3 -2.5 1.5 1.4 -1.7 -0.8 -1.4 -0.7 1.3 -2.3
Number of treatments/medications taken 0.4 0.7 2.0 0.8 -0.8 -0.9 0.4 0.9 0.9 0.3 -0.5 1.4
Average weekly spirits intake 0.4 0.5 1.7 -0.9 0.5 0.5 -0.6 -0.2 -0.5 -1.3 0.9 -0.6
Sensitivity / hurt feelings 0.3 0.5 1.7 1.1 -0.5 -0.4 0.4 0.2 0.4 0.8 -0.7 1.3
Frequency of depressed mood in last 2 weeks 1.1 1.6 2.7 -0.8 1.6 1.1 -1.4 -1.4 -1.2 -1.0 1.0 -1.5
Hearing difficulty/problems: Yes 0.4 0.6 0.8 0.9 -0.8 -0.8 0.8 0.8 0.8 0.6 -0.8 0.3
Relative age of first facial hair 0.3 0.7 1.0 -1.0 0.6 0.9 -0.8 -0.6 -0.9 -0.7 0.9 -0.9
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.5 -0.3 0.6 0.8 -1.0 -1.1 -0.8 -1.0 1.2 -0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.4 -1.2 0.7 0.9 -0.5 -0.6 -0.9 -1.0 0.8 -0.4
Ever had hysterectomy (womb removed) 1.5 1.7 2.4 -1.6 1.1 1.4 -1.2 -1.2 -1.3 -1.2 1.3 -1.5
Systolic blood pressure, automated reading 0.0 0.1 0.6 -0.0 0.0 0.1 -0.2 -0.1 -0.2 -0.8 0.3 0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 -0.2 0.7 0.5 -0.7 -0.8 -0.6 -0.6 0.5 0.1
Angina 0.2 0.2 0.5 -0.2 0.6 0.4 -0.7 -0.4 -0.5 -0.4 0.3 0.5
Medication for hormone replacement therapy 1.5 1.7 2.4 1.3 -1.4 -1.2 1.6 1.2 1.2 1.4 -1.5 0.8
Vitamin and mineral supplements 0.0 0.0 0.1 0.1 -0.1 0.0 0.2 -0.1 -0.0 0.1 0.1 0.4
Supplements: Zinc 0.2 0.2 0.4 0.4 -0.3 -0.6 0.2 0.5 0.5 0.5 -0.6 0.0
Medication: Co-codamol 0.1 0.1 0.5 -0.4 -0.1 -0.2 0.0 0.1 0.2 0.7 -0.2 0.4
Medication: Metformin 0.0 0.0 0.2 0.1 0.0 -0.1 -0.1 0.0 0.0 0.1 0.1 0.4
Diabetes (father) 1.1 1.3 2.0 0.9 -1.2 -1.4 1.0 1.4 1.4 1.2 -1.2 0.4
Diabetes (mother) 0.1 0.1 0.4 -0.0 -0.3 -0.4 0.2 0.6 0.4 0.4 -0.3 0.3
Severe depression (siblings) 0.3 0.3 0.9 -0.0 0.7 0.7 -0.3 -1.0 -0.7 -0.0 0.2 -0.5
Pack years adult smoking proportion 0.2 0.3 0.6 -0.3 0.6 0.5 -0.4 -0.5 -0.5 -0.8 0.6 -0.3
Impedance of leg (right) 0.1 0.5 1.3 -1.2 0.5 0.7 -0.5 -0.5 -0.6 -0.8 0.6 -0.6
Leg fat-free mass (left) 0.0 0.2 0.6 0.4 -0.4 -0.5 0.0 0.3 0.4 0.8 -0.3 -0.4
Trunk fat percentage 1.6 6.3 8.9 2.4 -2.7 -2.6 2.4 2.5 2.6 2.2 -2.2 3.0
Hand grip strength (right) 1.1 3.1 5.9 -2.4 1.7 1.7 -1.8 -1.2 -1.7 -1.1 1.4 -2.4
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.2 0.5 0.2 -0.5 -0.2 -0.2 -0.1 0.1 -0.3
Current tobacco smoking 0.1 0.1 0.3 0.0 0.2 -0.1 -0.2 0.3 0.1 -0.6 0.4 0.4
Average weekly fortified wine intake 0.8 0.9 2.0 0.6 -1.0 -1.0 1.3 0.7 1.0 0.9 -1.4 0.1
Maternal smoking around birth 1.0 1.4 2.4 -1.5 1.4 1.2 -1.3 -0.9 -1.3 -0.7 0.9 -1.3
Fed-up feelings 0.1 0.2 1.0 0.4 0.1 -0.3 0.5 0.2 0.3 0.6 -1.0 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.5 2.3 -0.7 1.5 1.1 -1.3 -1.4 -1.2 -1.4 1.1 -1.4
Relative age voice broke 0.1 0.2 1.1 -1.0 0.2 0.5 -0.1 0.0 -0.4 0.1 0.2 -0.4
Taking other prescription medications 0.9 1.4 4.1 0.9 -1.4 -1.1 1.0 1.1 1.1 0.6 -0.7 2.0
Age when periods started (menarche) 0.3 0.6 2.9 -1.7 0.3 0.4 -0.4 -0.2 -0.4 -0.2 0.2 -1.4
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.6 -0.4 -0.0 0.1 0.4 0.2 -0.1 0.5 -0.4 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 8.1 1.4 -2.1 -2.2 2.3 2.1 2.2 2.8 -2.6 0.9
Tinnitus: Yes, but not now, but have in the past 2.3 2.5 3.3 1.1 -1.5 -1.8 1.6 1.8 1.7 1.2 -1.7 1.7
Qualifications: CSEs or equivalent 0.7 0.9 3.3 -0.8 1.0 0.9 -0.7 -0.7 -0.9 -0.7 0.5 -1.8
Serious illness, injury or assault to yourself 0.9 1.2 2.6 -0.4 0.9 1.0 -1.4 -0.9 -1.0 -1.4 1.6 -0.2
High blood pressure 0.1 0.2 0.8 0.6 -0.2 -0.3 -0.0 0.3 0.2 0.1 -0.0 0.9
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.7 1.1 -1.1 -1.0 1.3 0.9 1.0 0.5 -1.0 0.9
Multivitamins +/- minerals 0.0 0.1 0.1 0.4 -0.1 -0.3 0.1 0.1 0.3 0.2 -0.3 0.0
Stomach or abdominal pain in last month 0.8 1.0 1.4 0.7 -0.9 -1.1 1.0 1.1 1.1 1.2 -1.1 0.8
Supplements: Glucosamine 0.7 0.9 1.5 0.8 -0.9 -0.8 1.0 0.8 0.9 1.1 -1.2 0.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.7 1.3 -0.8 -0.9 0.5 0.6 0.9 0.8 -0.6 1.1
Medication: Atenolol 0.2 0.2 1.4 0.5 -0.3 -0.5 0.1 0.2 0.4 0.1 -0.2 1.2
Medication: Levothyroxine sodium 0.1 0.1 0.7 -0.2 0.2 0.2 -0.0 -0.3 -0.2 -0.0 -0.0 -0.8
Sitting height 0.8 5.6 11.8 -2.7 2.1 2.1 -2.4 -2.2 -2.1 -1.5 2.1 -3.4
Chronic bronchitis/emphysema (father) 0.1 0.1 0.4 -0.2 -0.2 -0.2 -0.2 0.4 0.2 -0.0 0.1 0.6
High blood pressure (mother) 0.4 0.5 0.7 0.8 -0.8 -0.8 0.6 0.8 0.8 0.6 -0.5 0.4
Body mass index (BMI) 1.5 6.2 8.9 2.6 -2.5 -2.6 2.1 2.5 2.5 2.5 -2.2 3.0
Impedance of leg (left) 0.1 0.6 1.6 -1.3 0.6 0.8 -0.4 -0.6 -0.7 -0.8 0.5 -0.7
Leg predicted mass (left) 0.0 0.2 0.5 0.4 -0.3 -0.5 -0.0 0.3 0.4 0.7 -0.2 -0.5
Trunk fat mass 1.1 4.7 5.8 2.0 -2.4 -2.3 1.9 2.2 2.2 2.1 -1.9 2.4
Waist circumference 0.4 1.4 3.0 1.4 -1.2 -1.2 0.8 1.2 1.1 1.1 -0.6 1.7
Number of incorrect matches in round 1.0 1.6 2.3 -0.9 1.2 1.5 -1.0 -1.4 -1.4 -1.0 1.3 -1.4
Past tobacco smoking 0.9 1.7 2.8 -1.4 1.1 1.2 -1.4 -1.2 -1.1 -1.6 1.7 -0.9
Alcohol usually taken with meals 0.6 1.0 1.5 0.9 -1.0 -1.2 0.9 0.9 1.1 1.2 -1.0 0.7
Nervous feelings 0.4 0.8 1.9 -0.4 1.1 0.9 -0.8 -1.4 -0.9 -1.1 0.5 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.4 0.0 1.2 0.9 -0.7 -1.1 -1.0 -0.9 0.4 -1.1
Hearing difficulty/problems with background noise 0.4 0.6 1.1 -0.1 0.6 0.7 -0.9 -1.0 -0.7 -0.9 1.1 -0.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.6 -0.8 0.3 0.4 0.2 -0.4 -0.4 -0.5 -0.3 -1.3
Had menopause 0.5 0.7 1.6 -0.5 0.5 1.0 -0.4 -0.9 -0.9 -1.2 0.9 -0.7
Had other major operations 2.0 2.4 2.9 -1.4 1.6 1.6 -1.4 -1.7 -1.6 -1.4 1.4 -1.7
Forced vital capacity (FVC) 0.2 0.7 3.2 -1.1 0.3 0.3 0.1 -0.3 -0.3 1.1 -0.8 -1.8
Heel bone mineral density (BMD) T-score, automated (right) 2.5 5.7 9.2 1.9 -2.2 -2.5 2.3 2.4 2.4 3.0 -2.9 1.3
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.7 0.1 -0.1 -0.4 -0.2 0.4 0.3 -0.2 0.1 0.8
Qualifications: None of the above 0.4 0.8 1.3 -0.6 0.9 0.7 -1.0 -0.8 -0.8 -1.0 1.1 -0.9
Financial difficulties in last 2 years 0.2 0.3 0.9 0.6 0.0 -0.4 0.2 0.4 0.3 1.0 -0.5 0.7
Mouth/teeth dental problems 0.3 0.4 1.2 0.1 -0.9 -0.6 0.5 1.1 0.7 0.4 -0.4 0.2
Heart attack 0.2 0.2 0.5 0.3 -0.3 -0.4 0.3 0.4 0.4 0.7 -0.7 0.6
Allergy 0.0 0.1 0.3 0.0 0.1 -0.2 -0.3 0.2 0.1 0.2 -0.1 0.5
Pain all over the body in last month 0.1 0.1 0.1 0.2 -0.2 -0.2 0.3 0.4 0.2 0.3 -0.2 0.1
Diabetes (self-reported) 0.1 0.2 1.0 0.2 0.2 -0.1 -0.4 -0.3 -0.0 -0.3 0.3 1.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.5 0.2 -0.7 -0.5 0.3 0.6 0.5 0.3 -0.2 0.2
Medication: Ramipril 1.1 1.5 1.8 -1.3 1.3 1.3 -1.1 -1.1 -1.3 -1.0 0.9 -1.4
Medication: Simvastatin 0.1 0.2 0.8 0.6 -0.2 -0.3 0.2 0.2 0.2 0.5 -0.2 0.9
Fluid intelligence score 0.1 0.1 0.5 -0.1 0.2 -0.0 -0.6 0.1 -0.0 -0.3 0.7 0.2
Illnesses of siblings 0.0 0.0 0.1 -0.4 0.2 -0.1 0.2 -0.2 0.0 -0.2 -0.3 -0.0
Neuroticism score 0.1 0.2 0.7 0.7 0.4 -0.2 0.1 -0.3 0.1 0.2 -0.8 0.2
Weight 0.2 1.1 2.2 0.8 -1.2 -1.2 0.7 1.2 1.1 1.5 -1.0 0.7
Impedance of arm (right) 0.0 0.1 0.8 0.0 -0.3 0.1 0.3 -0.0 0.0 -0.2 0.1 -0.9
Arm fat percentage (right) 2.3 8.9 11.2 3.0 -3.2 -3.0 2.8 3.1 3.0 2.8 -2.6 3.4
Trunk fat-free mass 0.2 1.3 3.8 -1.4 1.1 0.8 -1.3 -0.9 -0.9 -0.2 0.8 -1.9
Hip circumference 0.5 2.0 3.4 1.4 -1.5 -1.6 1.0 1.6 1.5 1.8 -1.2 1.0
Time employed in main current job 1.3 1.5 2.3 0.6 -1.5 -1.2 1.4 1.2 1.3 1.2 -1.3 0.9
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.6 0.4 0.3 -0.5 -0.4 -0.3 0.1 0.4 0.1
Father’s age at death 1.4 1.9 2.7 1.1 -1.6 -1.4 1.6 1.2 1.4 1.5 -1.5 1.1
Worrier / anxious feelings 0.1 0.1 0.4 0.2 0.4 0.1 0.1 -0.5 -0.2 0.4 -0.6 -0.4
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 5.6 -1.4 2.2 1.9 -2.1 -2.1 -2.0 -2.4 1.9 -1.1
Falls in the last year 1.0 1.3 3.6 -1.1 1.0 1.1 -1.1 -1.1 -1.1 -1.9 1.1 -0.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.7 0.5 -0.4 -0.2 0.2 0.4 0.3 0.9 -0.2 0.5
Number of live births 0.1 0.1 0.3 0.4 -0.5 -0.3 0.6 0.4 0.3 0.2 -0.2 -0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.5 -0.7 0.0 0.0 0.3 -0.0 -0.0 1.2 -0.8 -1.0
Pulse rate 0.2 0.3 0.9 0.2 -0.6 -0.4 0.6 0.9 0.5 0.7 -0.4 0.6
Happiness 5.3 6.5 7.3 -2.7 2.7 2.5 -2.6 -2.7 -2.6 -2.6 2.4 -1.9
Noisy workplace 0.0 0.1 0.2 0.3 0.3 0.1 -0.0 -0.2 -0.1 0.1 -0.3 0.4
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.1 0.9 -0.7 -0.4 0.9 0.3 0.5 0.6 -1.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.7 0.8 -0.3 -0.7 0.5 0.4 0.6 0.3 -0.6 0.8
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.7 0.1 -0.0 0.4 -0.2 0.0 0.3 -0.4 0.8
Asthma 0.1 0.2 0.4 0.4 -0.5 -0.5 0.7 0.5 0.5 0.5 -0.3 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 0.3 -0.0 -0.0 -0.2 -0.0 0.0 0.1 0.0 0.3
Medication: Cholesterol lowering 3.5 5.5 7.5 2.7 -2.3 -2.4 1.9 2.4 2.3 2.5 -2.0 2.5
Depression (self-reported) 0.0 0.1 0.2 -0.3 0.1 0.3 0.1 -0.2 -0.2 0.2 -0.2 -0.5
Medication: Lansoprazole 0.2 0.2 1.0 0.5 0.0 0.0 -0.1 -0.5 -0.0 -0.6 0.1 1.0
Prospective memory result 1.9 2.3 5.2 2.1 -1.3 -1.2 1.3 1.2 1.3 2.3 -1.3 1.1
Lung cancer (father) 0.6 0.7 2.1 -0.9 0.5 0.5 -0.9 -0.6 -0.5 -1.2 1.4 0.6
Illnesses of mother 0.1 0.2 0.8 -0.7 0.0 0.2 0.1 -0.1 -0.2 -0.0 0.1 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.2 -1.0 0.6 0.5 -0.1 -0.6 -0.5 0.5 -0.4 -1.1
Pulse wave Arterial Stiffness index 0.2 0.2 1.0 0.3 -0.3 -0.3 0.5 0.4 0.3 0.1 -0.6 1.0
Impedance of arm (left) 0.0 0.1 0.4 -0.1 -0.2 0.1 0.3 -0.1 0.0 -0.4 0.1 -0.6
Arm fat mass (right) 1.3 5.2 5.8 2.2 -2.4 -2.4 2.0 2.4 2.3 2.4 -2.0 2.4
Trunk predicted mass 0.2 1.4 4.0 -1.5 1.1 0.9 -1.4 -0.9 -1.0 -0.2 0.8 -2.0
Standing height 0.9 8.8 22.9 -3.5 2.6 2.7 -2.7 -2.7 -2.7 -1.8 2.2 -4.8
Length of working week for main job 0.9 1.0 1.9 -0.4 1.1 0.9 -1.1 -1.1 -0.9 -1.4 1.1 -0.6
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.6 -0.2 -0.3 -0.1 0.4 0.3 0.1 0.2 0.0
Breastfed as a baby 0.9 1.1 3.1 -1.1 1.0 1.1 -0.7 -1.3 -1.1 -0.3 0.6 -1.8
Tense / ‘highly strung’ 0.0 0.1 0.2 -0.2 0.3 0.1 -0.2 -0.3 -0.2 -0.5 -0.0 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.7 0.3 0.3 0.0 0.1 -0.3 0.3 -0.3 -0.6
Hair/balding pattern: Pattern 4 0.1 0.2 0.9 0.4 -0.3 -0.5 0.4 0.3 0.4 0.3 -0.4 0.9
Birth weight of first child 0.1 0.1 0.2 -0.5 0.4 0.4 -0.3 -0.3 -0.4 0.3 0.0 -0.3
Peak expiratory flow (PEF) 0.2 0.4 1.1 0.1 -0.3 -0.5 0.6 0.5 0.4 1.0 -0.9 -0.7
Pulse wave reflection index 1.6 1.9 3.6 0.9 -1.3 -1.4 1.5 1.3 1.4 0.9 -1.7 1.9
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.3 1.2 -0.6 -1.1 1.1 0.7 0.9 1.2 -1.5 0.7
Loud music exposure frequency 0.2 0.2 0.4 0.5 0.6 0.3 -0.5 -0.6 -0.3 -0.3 0.4 0.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.9 1.2 -1.2 -1.1 1.5 1.0 1.1 1.2 -1.7 1.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.4 -0.4 1.1 0.7 -0.9 -1.2 -0.8 -0.6 0.5 -0.6
Blood clot in the leg (DVT) 3.9 5.0 8.0 -2.3 2.1 2.3 -2.2 -2.1 -2.3 -1.6 2.3 -2.8
Medication: Paracetamol 0.2 0.3 0.6 -0.3 0.8 0.4 -0.7 -0.6 -0.5 -0.8 0.4 -0.3
Headache pain in last month 0.1 0.2 0.9 -0.3 0.5 0.2 -0.3 -0.1 -0.3 -0.2 -0.2 -1.0
Medication for cholesterol, blood pressure or diabetes 3.8 6.2 8.8 -3.0 2.3 2.5 -2.0 -2.5 -2.5 -2.4 2.2 -2.9
Glaucoma (self-reported) 0.0 0.0 0.1 0.1 -0.0 -0.2 -0.1 0.3 0.2 0.1 -0.1 -0.1
Gout (self-reported) 0.4 0.5 0.9 0.4 -0.6 -0.6 0.8 0.8 0.7 1.0 -0.9 0.8
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.4 0.2 -0.0 0.1 -0.2 -0.1 -0.1 0.5 0.3 -0.6
Medication: Amlodipine 0.4 0.6 2.1 1.4 -0.5 -0.8 0.5 0.6 0.8 0.3 -0.5 1.0
Medication: Ventolin 100micrograms inhaler 2.5 3.2 4.4 1.4 -1.6 -2.0 1.6 2.1 1.9 1.8 -1.7 1.9
Birth weight 0.6 1.2 4.5 -1.5 1.0 0.8 -0.9 -0.6 -0.8 -0.4 0.7 -2.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.8 -0.9 0.7 0.6 -0.4 -0.4 -0.7 -0.1 0.2 -0.9
High blood pressure (siblings) 0.2 0.3 0.5 0.6 -0.6 -0.4 0.3 0.7 0.4 0.6 -0.2 0.5
Forced vital capacity (FVC), Best measure 0.2 0.9 3.3 -1.2 0.9 0.7 -0.4 -0.8 -0.7 0.5 -0.3 -1.8
Body fat percentage 2.0 7.8 11.7 2.7 -3.0 -2.8 2.5 2.8 2.8 2.5 -2.4 3.4
Leg fat percentage (right) 2.2 7.9 15.3 2.5 -3.0 -2.8 2.4 2.9 2.8 2.5 -2.3 3.9
Arm fat-free mass (right) 0.1 0.6 1.2 -1.1 0.8 0.6 -1.0 -0.6 -0.7 -0.2 0.6 -1.1
Exposure to tobacco smoke outside home 0.8 1.0 1.3 -0.8 1.2 1.0 -1.1 -0.9 -1.0 -0.9 1.1 -1.0
Comparative body size at age 10 0.6 1.6 3.4 1.6 -1.0 -1.3 1.1 1.3 1.2 1.9 -1.4 0.3
Number of full brothers 0.2 0.3 0.6 -0.2 -0.5 -0.5 0.7 0.8 0.5 0.3 -0.7 0.1
Worry too long after embarrassment 0.1 0.2 0.6 0.6 -0.3 -0.4 0.5 0.2 0.4 0.3 -0.8 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.7 -1.3 0.7 0.9 -0.8 -1.0 -0.8 -0.9 1.0 0.2
Wheeze or whistling in the chest in last year 0.6 1.1 2.5 -0.8 0.9 0.8 -1.1 -0.6 -0.8 -1.6 1.5 -0.2
Number of children fathered 0.1 0.1 0.2 0.2 -0.3 -0.3 0.3 0.4 0.3 0.5 -0.3 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.0 -1.0 0.9 1.3 -0.8 -1.0 -1.2 -0.3 0.8 -2.0
Age at first live birth 2.7 4.8 7.1 2.0 -2.2 -2.1 2.6 1.8 2.1 2.1 -2.7 2.1
Pulse wave peak to peak time 0.5 0.6 2.1 -0.7 0.6 0.5 -0.7 -0.6 -0.5 -0.3 0.7 -1.5
Health satisfaction 0.2 0.2 0.4 0.3 -0.4 -0.6 0.4 0.6 0.5 0.5 -0.4 0.3
Shortness of breath walking on level ground 1.0 1.2 1.8 1.0 -1.0 -1.1 0.9 1.1 1.1 0.9 -1.2 1.4
Qualifications: College or University degree 0.4 1.1 3.8 -1.4 0.9 1.0 -0.6 -0.7 -1.0 -0.5 0.6 -2.0
Eye problems/disorders: None of the above 0.4 0.4 0.8 0.9 -0.7 -0.7 0.4 0.6 0.7 0.8 -0.5 0.6
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.5 -1.2 0.8 0.9 -0.8 -0.6 -0.9 -0.8 0.8 -0.7
Emphysema/chronic bronchitis 1.2 1.3 2.1 -0.7 0.9 1.2 -1.0 -1.4 -1.2 -1.2 1.4 -1.0
Medication for pain relief, constipation, heartburn 0.2 0.4 0.8 -0.0 -0.7 -0.6 0.9 0.7 0.6 0.6 -0.9 0.2
Neck or shoulder pain in last month 0.2 0.3 0.5 -0.6 0.6 0.7 -0.6 -0.5 -0.7 -0.0 0.6 -0.6
Medication: Blood pressure 0.4 0.8 2.1 1.3 -0.7 -0.8 0.3 0.8 0.8 0.6 -0.5 1.5
Angina (self-reported) 0.3 0.3 0.7 -0.4 0.8 0.5 -0.8 -0.5 -0.6 -0.6 0.5 0.3
Migraine (self-reported) 2.0 2.4 3.5 1.0 -1.8 -1.6 1.6 1.9 1.6 1.8 -1.5 0.9
Medication: Ibuprofen 0.0 0.0 0.2 0.2 0.1 0.0 -0.5 -0.1 -0.0 0.1 0.3 0.1
Medication: Allopurinol 1.2 1.5 2.0 1.3 -1.3 -1.2 1.2 1.4 1.2 1.4 -1.1 1.0
Medication: Omeprazole 0.1 0.1 0.5 -0.4 0.1 0.0 -0.6 0.1 -0.1 -0.4 0.7 0.4
Medication: Seretide 50 evohaler 0.1 0.2 0.7 0.3 0.0 -0.0 0.5 -0.3 0.0 -0.5 -0.3 0.8
Mean time to correctly identify matches 0.1 0.2 0.9 0.4 0.4 0.3 -0.4 -1.0 -0.3 -0.3 0.4 0.1
Heart disease (mother) 1.7 2.1 3.0 -1.3 1.7 1.6 -1.5 -1.5 -1.6 -1.5 1.4 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.0 0.8 -0.9 -1.2 1.2 1.2 1.1 0.9 -1.4 1.2
Whole body fat mass 1.1 4.7 6.2 2.0 -2.3 -2.2 1.9 2.2 2.2 2.1 -1.9 2.5
Leg fat mass (right) 1.2 4.8 7.5 2.0 -2.3 -2.2 1.9 2.3 2.2 2.1 -1.9 2.7
Arm predicted mass (right) 0.1 0.7 1.2 -0.9 0.9 0.7 -1.1 -0.8 -0.8 -0.2 0.6 -1.1
Pulse rate, automated reading 0.2 0.5 1.0 -1.0 0.9 0.8 -0.5 -0.4 -0.8 -1.0 0.6 -0.1
Alcohol intake frequency. 0.1 0.2 0.5 0.3 0.6 -0.0 -0.2 -0.1 -0.1 0.5 -0.3 -0.7
Comparative height size at age 10 0.2 1.3 5.7 -1.1 0.8 0.9 -1.0 -0.9 -0.9 -0.5 1.0 -2.4
Number of full sisters 1.2 1.5 2.7 -1.1 1.2 1.2 -1.4 -1.4 -1.2 -0.9 1.6 -0.7
Suffer from ‘nerves’ 0.7 1.1 1.8 -1.1 1.3 1.0 -1.1 -1.3 -1.1 -1.0 0.5 -0.7
Overall health rating 0.0 0.0 0.1 0.3 0.1 -0.0 -0.0 0.1 0.0 0.1 0.0 -0.0
Chest pain or discomfort 0.4 0.6 2.4 0.4 -0.6 -0.8 0.1 1.0 0.8 -0.4 -0.1 1.6
Had major operations 3.4 3.9 6.1 1.7 -1.8 -2.0 2.2 1.8 2.0 2.0 -2.5 1.8
Age at last live birth 0.1 0.1 0.3 -0.1 -0.0 0.1 0.6 -0.1 -0.1 -0.1 -0.5 -0.1
Family relationship satisfaction 0.2 0.3 0.9 -0.2 0.7 0.4 -0.6 -1.0 -0.5 -0.5 0.3 0.3
Leg pain on walking 0.0 0.1 0.2 0.2 0.4 0.2 -0.2 -0.2 -0.2 -0.1 -0.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.6 -0.5 0.7 0.5 -0.5 -0.6 -0.6 -0.6 0.4 -0.8
Commuting to job workplace: Car/motor vehicle 1.1 1.2 1.8 1.2 -1.1 -1.1 1.1 1.0 1.1 1.4 -1.1 0.8
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.4 -0.4 -0.6 -0.2 0.6 0.3 0.3 0.3 -0.4 -0.7
Medication: Aspirin 0.1 0.1 0.3 0.5 0.1 0.2 -0.3 -0.2 -0.2 0.1 0.6 -0.2
Supplements: Vitamin C 0.1 0.1 0.4 -0.3 0.2 0.1 -0.4 0.1 -0.1 -0.3 0.3 -0.6
Knee pain experienced in last month 0.1 0.2 0.5 -0.2 0.5 0.6 -0.7 -0.6 -0.6 -0.0 0.5 0.0
Hypertension (Self-reported) 0.0 0.1 0.7 0.5 0.0 -0.1 -0.2 0.1 0.0 -0.1 0.1 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.2 -1.1 0.6 0.8 -0.8 -1.0 -0.8 -1.1 0.7 -0.7
Illnesses of father: Heart disease 0.1 0.1 0.4 -0.1 0.3 0.3 -0.1 -0.4 -0.3 -0.2 0.0 -0.6
Illnesses of siblings: Diabetes 0.7 0.8 1.5 0.4 -0.9 -0.9 0.8 1.2 0.9 1.2 -0.9 0.2
Smoking status: Previous 0.9 1.3 2.2 1.2 -1.0 -1.0 1.1 0.9 1.0 1.4 -1.5 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.1 -0.1 -0.3 -0.5 0.6 0.3 0.5 1.0 -1.0 -0.3
Whole body fat-free mass 0.1 0.4 1.7 -0.7 0.6 0.3 -0.8 -0.5 -0.4 0.2 0.4 -1.3
Leg fat-free mass (right) 0.0 0.1 0.5 0.1 0.0 -0.2 -0.3 -0.0 0.1 0.5 -0.0 -0.7
Arm fat percentage (left) 2.2 8.9 12.4 3.0 -3.1 -3.0 2.7 3.0 3.0 2.7 -2.6 3.5
Average weekly red wine intake 0.7 1.1 2.4 0.4 -1.1 -1.0 1.1 1.1 1.0 1.6 -1.2 -0.3
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.7 0.2 0.1 0.1 -0.2 -0.1 -0.1 -0.3 0.2 0.8
Mood swings 0.2 0.3 0.8 0.9 -0.1 -0.5 0.4 0.2 0.4 0.6 -0.8 0.7
Loneliness, isolation 0.6 0.9 1.8 -0.9 1.3 0.8 -1.1 -0.8 -1.0 -0.5 0.4 -1.2
Long-standing illness, disability or infirmity 0.4 0.5 1.1 0.9 -0.5 -0.8 0.5 0.7 0.7 0.6 -0.8 1.0
Ever had bowel cancer screening 0.8 1.0 1.5 -1.1 0.9 1.0 -0.7 -1.2 -1.0 -1.2 0.8 -1.0
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.0 0.5 0.1 -0.5 -0.4 -0.2 -0.4 0.4 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.5 -0.7 0.3 0.4 -0.2 -0.2 -0.3 -0.2 0.2 0.1
Friendships satisfaction 2.1 2.6 3.1 -1.7 1.8 1.6 -1.5 -1.7 -1.6 -1.7 1.3 -1.7
Qualifications: nursing, teaching 0.1 0.2 1.4 0.3 -0.2 -0.2 0.1 0.3 0.2 0.3 -0.2 1.2
Commuting to job workplace: Walk 6.5 7.0 8.3 -2.4 2.9 2.4 -2.8 -2.7 -2.6 -2.9 2.4 -2.6
Eye problems/disorders: Cataract 2.2 2.5 4.4 -2.1 1.5 1.5 -1.4 -1.3 -1.5 -1.9 1.5 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 0.5 -0.6 -0.6 0.7 0.5 0.6 0.4 -0.5 0.4
Medication for cholesterol 0.0 0.0 0.2 -0.4 0.0 -0.1 -0.2 0.1 0.1 0.2 0.1 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.3 -0.9 1.2 0.7 -0.6 -0.9 -0.8 -0.9 0.3 -0.4
Back pain experienced in last month 0.1 0.1 0.4 -0.1 0.2 0.1 -0.6 -0.2 -0.2 0.1 0.4 0.5
Mineral and other dietary supplements 0.1 0.2 0.6 -0.0 0.3 0.3 -0.6 -0.3 -0.3 -0.4 0.8 -0.1
Breast cancer (self-reported) 0.2 0.2 0.5 0.4 0.3 0.2 -0.5 -0.5 -0.3 -0.6 0.6 0.7
Asthma (self-reported) 0.1 0.1 0.3 0.2 -0.4 -0.2 0.6 0.3 0.3 0.4 -0.2 0.3
Osteoporosis (self-reported) 1.9 2.3 3.5 -1.0 1.5 1.6 -1.6 -1.9 -1.6 -1.5 1.9 -0.9
Osteoarthritis (self-reported) 0.9 1.2 3.1 -1.2 1.1 1.2 -0.6 -1.3 -1.2 -0.4 0.3 -1.8
Medication: Aspirin 0.1 0.2 0.6 0.5 0.1 0.3 -0.5 -0.4 -0.3 -0.1 0.8 -0.2
Medication: Gliclazide 0.2 0.2 1.1 -0.2 -0.3 -0.4 0.2 0.7 0.4 1.0 -0.4 0.1
Illnesses of father: None of the above (group 1) 1.2 1.5 1.9 -1.0 1.3 1.3 -1.3 -1.4 -1.3 -1.3 1.3 -0.4
Smoking status: Current 0.0 0.1 0.2 -0.1 0.2 -0.2 -0.2 0.4 0.1 -0.4 0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 -0.5 0.2 0.4 -0.3 -0.5 -0.4 -0.1 0.2 -0.3
Whole body water mass 0.1 0.5 2.1 -0.8 0.6 0.4 -0.9 -0.6 -0.5 0.1 0.4 -1.4
Leg predicted mass (right) 0.0 0.1 0.6 0.2 0.0 -0.2 -0.2 -0.0 0.1 0.6 -0.0 -0.8
Arm fat mass (left) 1.1 4.7 5.8 2.1 -2.3 -2.3 1.9 2.3 2.2 2.2 -1.9 2.4
Number of self-reported non-cancer illnesses 0.1 0.1 0.7 0.1 -0.2 -0.0 -0.1 -0.0 0.1 -0.5 0.2 0.8
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -0.7 1.0 0.8 -0.7 -0.9 -0.8 -1.1 0.7 -0.6
Miserableness 0.1 0.1 0.6 0.4 0.2 -0.3 0.2 -0.0 0.2 0.3 -0.8 0.1
Guilty feelings 0.1 0.2 0.4 0.6 0.1 -0.4 -0.0 0.2 0.3 0.5 -0.5 0.5
Wears glasses or contact lenses 0.1 0.1 0.3 0.1 0.4 0.3 -0.4 -0.2 -0.3 -0.6 0.5 0.3
Ever taken oral contraceptive pill 4.0 4.5 5.7 2.0 -2.4 -2.2 2.2 2.0 2.3 1.9 -2.0 2.0
Hearing aid user 0.9 1.0 1.6 0.7 -1.1 -1.1 0.9 1.3 1.1 0.5 -0.9 1.1
Mother’s age at death 0.3 0.4 1.3 0.1 -0.6 -0.3 1.1 0.5 0.4 0.6 -1.0 0.5
Financial situation satisfaction 0.9 1.1 2.8 1.4 -0.7 -1.0 0.7 0.7 0.9 1.0 -0.9 1.7
Tinnitus: Yes, now most or all of the time 3.7 4.3 5.4 -1.4 2.3 2.2 -1.9 -2.3 -2.2 -2.1 1.9 -2.1
Commuting to job workplace: Public transport 0.5 0.6 1.0 -0.6 0.9 0.7 -0.7 -1.0 -0.8 -0.9 0.7 -0.1
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 -0.5 0.7 0.8 -0.8 -0.8 -0.8 -0.6 0.8 -1.1
Medication: Blood pressure 0.2 0.4 0.9 -0.2 0.6 0.7 -0.7 -0.6 -0.6 -0.9 0.8 -0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.4 -0.3 0.3 0.5 -0.3 -0.4 -0.4 -0.0 0.1 -0.6
Supplements: Fish oil (including cod liver oil) 0.0 0.1 0.3 -0.3 0.2 0.0 0.2 -0.0 -0.0 -0.0 -0.5 -0.4
High cholesterol (Self-reported) 0.0 0.1 0.5 -0.0 0.0 0.2 0.3 -0.1 -0.1 0.7 -0.3 0.1
Medication: Bendroflumethiazide 0.3 0.5 1.8 -0.0 0.4 0.5 -0.8 -0.4 -0.5 -1.3 1.0 0.4
Medication: Paracetamol 0.2 0.3 0.5 -0.4 0.7 0.5 -0.7 -0.6 -0.5 -0.6 0.5 -0.4
Medication: Lisinopril 0.9 1.2 2.6 1.5 -1.3 -1.1 0.3 1.0 1.1 0.9 -0.2 1.6
Medication: Atorvastatin 0.1 0.1 0.4 0.5 -0.3 -0.2 0.2 0.3 0.3 0.4 0.0 0.6
Illnesses of father: High blood pressure 0.1 0.1 0.4 0.2 -0.4 -0.5 0.1 0.4 0.5 0.2 -0.1 0.6
Alcohol drinker status: Never 0.2 0.2 0.3 0.4 -0.4 -0.5 0.6 0.5 0.5 -0.2 -0.4 0.4
Ever smoked 1.1 2.0 3.0 1.7 -1.1 -1.4 1.6 1.3 1.3 1.6 -1.7 0.8
Basal metabolic rate 0.0 0.2 0.8 -0.3 0.1 -0.1 -0.4 -0.0 -0.0 0.6 -0.0 -0.9
Leg fat percentage (left) 2.1 7.5 14.4 2.4 -2.8 -2.7 2.4 2.8 2.7 2.5 -2.4 3.8
Arm fat-free mass (left) 0.1 0.6 1.4 -0.9 0.8 0.6 -1.0 -0.6 -0.7 -0.1 0.5 -1.2
Number of operations (self-reported) 0.1 0.1 0.3 0.3 -0.4 -0.4 0.2 0.2 0.4 0.5 -0.3 0.6
Average weekly beer plus cider intake 0.1 0.1 0.2 0.2 0.3 0.2 -0.1 -0.3 -0.2 -0.4 0.2 0.4
Irritability 0.1 0.2 1.0 -0.3 0.7 0.2 -0.1 -0.3 -0.3 0.1 -0.5 -1.0
Risk taking 0.6 0.9 1.6 -1.0 1.0 0.8 -1.3 -0.8 -0.8 -1.0 1.2 -0.5
Ever had prostate specific antigen (PSA) test 1.7 2.0 2.8 1.1 -1.7 -1.4 1.5 1.7 1.5 1.2 -1.2 1.4
Fractured/broken bones in last 5 years 0.9 1.2 3.5 -0.8 0.9 0.7 -1.3 -1.0 -0.8 -1.9 1.4 -0.3
Age started oral contraceptive pill 1.3 1.6 2.3 1.0 -1.4 -1.2 1.5 1.4 1.2 1.0 -1.3 1.2
Diastolic blood pressure, automated reading 0.1 0.4 1.2 0.1 0.5 0.6 -0.5 -0.8 -0.6 -1.1 0.6 0.4
Ever depressed for a whole week 0.1 0.2 0.6 -0.8 0.4 0.4 -0.4 -0.1 -0.4 -0.4 0.3 -0.0
Unable to work because of sickness or disability 0.5 0.7 1.8 1.4 -0.7 -0.7 0.5 0.7 0.7 0.7 -0.2 1.3
Commuting to job workplace: Cycle 0.1 0.1 0.5 0.7 -0.1 -0.3 0.1 0.2 0.2 0.1 -0.3 0.1
Myopia 0.1 0.1 0.2 -0.4 0.4 0.4 -0.3 -0.5 -0.4 -0.4 0.2 -0.2
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.8 -0.4 -0.0 0.1 0.2 -0.1 -0.0 0.1 -0.0 -0.9
Cholesterol lowering medication 0.4 0.5 1.0 -1.0 0.7 0.9 -0.3 -0.8 -0.8 -0.8 0.6 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.5 0.0 -0.3 -0.2 -0.1 0.2 0.2 -0.3 0.5 0.7
Pain experienced in last month 0.1 0.2 0.4 0.4 -0.4 -0.4 0.7 0.2 0.5 -0.1 -0.3 0.2
Supplements: Calcium 0.2 0.2 0.5 -0.2 0.4 0.4 -0.4 -0.4 -0.4 -0.7 0.7 -0.6
Basal cell carcinoma (self-reported) 2.3 2.8 5.0 -2.0 1.6 1.5 -1.7 -1.3 -1.5 -2.2 1.7 -1.3
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.1 -0.1 -0.2 0.1 0.2 0.2 0.3 -0.4 0.5
Deep venous thrombosis (DVT) (self-reported) 5.3 6.8 9.6 -2.6 2.5 2.7 -2.5 -2.5 -2.6 -2.0 2.8 -3.1
Heart disease (siblings) 0.1 0.2 0.3 -0.1 0.4 0.5 -0.5 -0.5 -0.5 -0.3 0.4 -0.3
Alcohol drinker status: Previous 0.9 1.0 3.6 -0.5 1.2 1.0 -0.6 -1.0 -1.0 -0.1 0.1 -1.9
Pack years of smoking 0.4 0.7 1.2 -0.5 0.9 0.8 -0.7 -0.9 -0.8 -1.1 0.9 -0.6
Impedance of whole body 0.0 0.1 0.4 -0.5 0.1 0.3 0.1 -0.2 -0.2 -0.5 0.2 -0.6
Leg fat mass (left) 1.3 4.9 7.2 2.0 -2.3 -2.3 1.9 2.3 2.2 2.2 -2.0 2.7
Arm predicted mass (left) 0.1 0.5 1.3 -1.0 0.7 0.5 -0.9 -0.5 -0.6 -0.0 0.5 -1.1