Hub : Genes

TSG101

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1498	0.0441	1.3e-05	0.064	NA	0.069	NA	0.069	9.1e-06	NA	4.1e-06	NA	4.1e-06
2	GTEx	Cells EBV-transformed lymphocytes	0.4300	0.0830	1.4e-07	0.461	NA	0.397	NA	0.460	8.3e-17	NA	4.8e-14	NA	9.0e-17
3	GTEx	Esophagus Mucosa	0.2550	0.0540	2.8e-09	0.264	NA	0.246	NA	0.266	8.3e-18	NA	1.5e-16	NA	6.3e-18
4	GTEx	Heart Left Ventricle	0.1416	0.0445	3.4e-04	0.090	NA	0.093	NA	0.099	1.7e-05	NA	1.2e-05	NA	6.4e-06
5	GTEx	Muscle Skeletal	0.2932	0.0428	0.0e+00	0.277	NA	0.250	NA	0.281	3.3e-27	NA	2.3e-24	NA	1.1e-27
6	GTEx	Thyroid	0.0770	0.0320	7.3e-03	0.090	NA	0.088	NA	0.092	2.0e-07	NA	3.0e-07	NA	1.5e-07
7	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0690	0.0360	1.2e-03	0.073	0.063	0.056	NA	0.060	5.8e-05	0.00018	4.0e-04	NA	2.5e-04
8	TCGA	Lung Squamous Cell Carcinoma	0.0293	0.0138	1.2e-04	0.031	0.030	0.035	NA	0.032	1.5e-04	0.00021	6.2e-05	NA	1.5e-04
9	TCGA	Thyroid Carcinoma	0.0340	0.0190	1.3e-03	0.032	0.027	0.034	NA	0.027	3.7e-04	0.00110	2.8e-04	NA	1.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.8	1.2	1.8	-1.3	1.1	1.0	-1.0	-1.1	-1.1	-1.2	1.1	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-1.1	0.7	0.5	-0.5	-0.4	-0.6	-0.9	0.2	-0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.3	0.1	0.4	0.1	0.1	-0.3	-0.2	0.4	-0.5	-0.3
Depression (Nagel 2018)	1.9	2.9	4.4	-1.3	1.9	1.7	-1.7	-1.8	-1.7	-1.4	1.3	-2.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	0.6	-0.6	-0.7	0.6	0.7	0.6	0.2	-0.5	0.8
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.0	0.7	0.5	-0.2	-0.7	-0.5	0.1	-0.3	-0.1
Schizophrenia (2018)	0.0	0.1	0.3	-0.3	0.0	-0.3	0.1	0.4	0.2	-0.2	-0.6	0.1
Schizophrenia vs Biploar Disorder	2.3	3.1	5.4	1.2	-1.7	-1.7	2.2	1.8	1.7	1.8	-2.3	1.0
Worry (Nagel 2018)	0.1	0.3	0.8	-0.3	0.7	0.7	-0.4	-0.9	-0.7	-0.5	0.1	-0.1
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	0.8	-1.0	-1.3	1.1	1.3	1.3	0.6	-1.3	1.5
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.4	-0.4	-0.4	0.2	0.3	0.4	0.8	-0.2	0.5
Alzheimer’s Disease (including proxy)	1.4	2.0	2.6	1.2	-1.2	-1.6	1.4	1.5	1.6	1.1	-1.4	1.5
Crohns Disease (2017)	0.6	1.2	3.1	0.7	-0.7	-1.0	1.6	0.8	1.0	1.3	-1.7	-0.2
Irritable Bowel Disease (IBD)	1.7	4.0	6.9	1.7	-1.7	-2.1	2.3	1.8	1.9	2.2	-2.6	1.4
Ulcerative Colitis (UC)	1.1	2.1	3.2	1.2	-1.3	-1.5	1.5	1.3	1.3	1.4	-1.8	1.5
Major Depression (MDD)	0.7	0.9	1.4	0.7	-1.0	-0.9	1.2	1.1	0.9	0.9	-1.1	0.4
Reaction Time	0.2	0.4	1.4	0.1	0.7	0.6	-0.7	-1.2	-0.6	-0.2	0.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.8	0.9	-0.7	-0.8	0.6	0.7	0.8	0.7	-0.4	0.8
Breast Cancer	4.8	11.7	15.4	-3.3	3.4	3.2	-3.1	-3.1	-3.3	-3.8	3.3	-3.9
Ovarian Cancer	1.5	2.0	2.5	1.6	-1.5	-1.4	1.5	1.2	1.5	1.3	-1.5	1.1
Prostate Cancer	0.9	1.2	1.9	-0.3	1.2	0.9	-1.4	-1.1	-1.0	-1.3	1.2	-1.2
Age at First Birth	0.1	0.1	0.2	-0.3	0.1	0.4	0.3	-0.4	-0.3	-0.3	-0.4	0.4
Bipolar Disorder (2011)	0.2	0.2	0.9	0.1	0.3	0.2	-0.8	-0.3	-0.2	-0.5	0.9	-0.1
Body Mass Index (BMI) (2010)	1.2	1.7	3.3	1.1	-1.3	-1.4	0.8	1.6	1.4	1.2	-0.9	1.8
Coronary Artery Disease (CAD)	2.0	2.4	4.3	2.1	-1.5	-1.7	1.6	1.3	1.5	2.0	-1.3	0.6
Crohns Disease (2012)	0.8	1.2	2.7	1.0	-0.8	-1.3	1.3	1.1	1.2	1.0	-1.6	0.3
Mean Putamen Volume	0.2	0.3	1.5	-0.8	0.2	0.1	0.1	0.0	-0.2	-0.2	-0.2	-1.2
Fasting Glucose	1.1	1.3	2.4	0.8	-1.3	-1.2	1.2	1.3	1.1	1.5	-1.0	0.6
HbA1C	0.8	0.9	3.5	0.5	-0.7	-0.5	0.9	0.5	0.8	1.0	-1.9	0.9
HDL Cholesterol	0.3	0.5	0.9	0.9	-0.5	-0.8	0.6	0.7	0.8	0.5	-0.7	0.4
LDL Cholesterol	5.0	8.0	11.6	3.4	-2.8	-2.6	3.0	2.4	2.7	2.7	-2.9	2.8
Lupus	0.1	0.2	0.8	0.2	0.1	-0.3	0.1	0.3	0.3	0.9	-0.3	-0.4
Neuroticism (2016)	1.0	1.4	2.5	0.9	-1.1	-1.0	1.3	1.0	1.0	1.6	-1.5	0.9
Primary Biliary Cirrhosis	0.3	0.4	2.3	-0.8	0.5	0.3	-0.3	-0.4	-0.3	-0.1	0.0	-1.5
Rheumatoid Arthritis	0.2	0.2	0.5	0.6	-0.4	-0.4	0.5	0.2	0.4	0.7	-0.5	0.1
Schizophrenia (2014)	0.1	0.1	0.5	-0.7	0.2	-0.2	0.1	0.3	-0.1	-0.1	-0.6	-0.3
Triglycerides	2.2	3.6	5.0	1.9	-2.1	-1.8	2.0	1.7	1.8	1.8	-1.8	2.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.0	-0.4	-0.5	0.4	0.6	0.5	0.6	-0.7	-0.5
Ulcerative Colitis	1.4	2.0	3.4	1.1	-1.3	-1.5	1.4	1.4	1.2	1.5	-1.8	1.2
Blood Eosinophil Count	0.0	0.2	0.8	0.1	-0.2	0.4	-0.3	-0.2	-0.2	-0.1	0.6	-0.9
Blood Platelet Count	0.2	2.7	3.7	-1.0	1.9	1.6	-1.9	-1.8	-1.7	-1.5	1.7	-1.5
Blood Red Count	0.2	2.1	4.4	1.5	-1.5	-1.4	1.3	1.5	1.4	1.1	-1.1	2.1
Blood White Count	0.2	1.7	4.8	-0.5	1.4	1.1	-1.3	-1.1	-1.2	-2.2	1.7	-0.4
Heel T-Score	0.1	0.5	1.1	-1.0	0.9	0.8	-0.6	-0.7	-0.8	-0.3	0.0	-0.4
BMI	0.6	3.4	4.2	1.9	-1.8	-2.0	1.5	2.0	1.9	1.9	-1.6	1.8
Height	1.0	19.1	41.6	-5.4	3.9	4.1	-4.4	-3.6	-4.1	-2.5	3.7	-6.5
Waist Hip Ratio (WHR)	0.0	0.1	0.3	0.1	-0.1	0.2	0.4	-0.2	-0.2	-0.5	0.1	0.5
Systolic Blood Pressure	0.1	0.4	1.4	0.0	0.5	0.4	-0.7	-0.5	-0.5	-1.2	1.0	0.4
Smoking Status	0.0	0.1	0.2	0.3	0.0	-0.4	0.2	0.5	0.3	0.3	-0.4	0.2
Allergy or Eczema	0.0	0.1	0.5	0.7	-0.0	-0.1	0.1	-0.1	0.1	-0.4	-0.1	0.3
Cardiovascular Disease	0.3	1.1	2.0	1.4	-1.0	-0.9	1.0	0.7	0.9	1.0	-1.0	1.3
Hypothyroidism (self reported)	0.1	0.2	1.0	0.3	-0.1	0.0	-0.1	-0.0	0.0	1.0	-0.0	-0.8
Respiratory disease	0.4	0.9	1.1	1.0	-0.9	-0.9	1.0	1.0	0.9	1.1	-0.8	0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.5	0.3	0.1	-0.5	0.1	0.3	0.4	-0.2	-0.2	0.7
Lung FEV1/FVC ratio	0.7	3.5	5.1	-2.3	1.9	1.8	-2.0	-1.8	-1.8	-2.0	2.1	-0.9
Lung FVC	0.1	0.5	1.7	0.3	-0.4	-0.4	0.7	0.4	0.4	1.3	-1.1	0.4
Neuroticism	0.1	0.3	1.1	0.7	0.1	-0.4	0.4	0.2	0.3	0.7	-1.0	0.1
Chronotype (morning person)	0.3	0.6	1.3	0.0	0.8	0.7	-1.1	-0.7	-0.7	-0.1	1.0	-1.1
Hair Pigment	0.0	0.3	1.4	1.2	-0.1	-0.4	0.1	0.1	0.3	0.8	-0.5	0.1
Tanning	0.0	0.4	0.8	-0.9	0.7	0.5	-0.8	-0.6	-0.5	-0.8	0.4	0.4
Hand grip strength (left)	1.0	2.6	6.3	-2.5	1.5	1.4	-1.7	-0.8	-1.4	-0.7	1.3	-2.3
Number of treatments/medications taken	0.4	0.7	2.0	0.8	-0.8	-0.9	0.4	0.9	0.9	0.3	-0.5	1.4
Average weekly spirits intake	0.4	0.5	1.7	-0.9	0.5	0.5	-0.6	-0.2	-0.5	-1.3	0.9	-0.6
Sensitivity / hurt feelings	0.3	0.5	1.7	1.1	-0.5	-0.4	0.4	0.2	0.4	0.8	-0.7	1.3
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.7	-0.8	1.6	1.1	-1.4	-1.4	-1.2	-1.0	1.0	-1.5
Hearing difficulty/problems: Yes	0.4	0.6	0.8	0.9	-0.8	-0.8	0.8	0.8	0.8	0.6	-0.8	0.3
Relative age of first facial hair	0.3	0.7	1.0	-1.0	0.6	0.9	-0.8	-0.6	-0.9	-0.7	0.9	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	-0.3	0.6	0.8	-1.0	-1.1	-0.8	-1.0	1.2	-0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.4	-1.2	0.7	0.9	-0.5	-0.6	-0.9	-1.0	0.8	-0.4
Ever had hysterectomy (womb removed)	1.5	1.7	2.4	-1.6	1.1	1.4	-1.2	-1.2	-1.3	-1.2	1.3	-1.5
Systolic blood pressure, automated reading	0.0	0.1	0.6	-0.0	0.0	0.1	-0.2	-0.1	-0.2	-0.8	0.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	-0.2	0.7	0.5	-0.7	-0.8	-0.6	-0.6	0.5	0.1
Angina	0.2	0.2	0.5	-0.2	0.6	0.4	-0.7	-0.4	-0.5	-0.4	0.3	0.5
Medication for hormone replacement therapy	1.5	1.7	2.4	1.3	-1.4	-1.2	1.6	1.2	1.2	1.4	-1.5	0.8
Vitamin and mineral supplements	0.0	0.0	0.1	0.1	-0.1	0.0	0.2	-0.1	-0.0	0.1	0.1	0.4
Supplements: Zinc	0.2	0.2	0.4	0.4	-0.3	-0.6	0.2	0.5	0.5	0.5	-0.6	0.0
Medication: Co-codamol	0.1	0.1	0.5	-0.4	-0.1	-0.2	0.0	0.1	0.2	0.7	-0.2	0.4
Medication: Metformin	0.0	0.0	0.2	0.1	0.0	-0.1	-0.1	0.0	0.0	0.1	0.1	0.4
Diabetes (father)	1.1	1.3	2.0	0.9	-1.2	-1.4	1.0	1.4	1.4	1.2	-1.2	0.4
Diabetes (mother)	0.1	0.1	0.4	-0.0	-0.3	-0.4	0.2	0.6	0.4	0.4	-0.3	0.3
Severe depression (siblings)	0.3	0.3	0.9	-0.0	0.7	0.7	-0.3	-1.0	-0.7	-0.0	0.2	-0.5
Pack years adult smoking proportion	0.2	0.3	0.6	-0.3	0.6	0.5	-0.4	-0.5	-0.5	-0.8	0.6	-0.3
Impedance of leg (right)	0.1	0.5	1.3	-1.2	0.5	0.7	-0.5	-0.5	-0.6	-0.8	0.6	-0.6
Leg fat-free mass (left)	0.0	0.2	0.6	0.4	-0.4	-0.5	0.0	0.3	0.4	0.8	-0.3	-0.4
Trunk fat percentage	1.6	6.3	8.9	2.4	-2.7	-2.6	2.4	2.5	2.6	2.2	-2.2	3.0
Hand grip strength (right)	1.1	3.1	5.9	-2.4	1.7	1.7	-1.8	-1.2	-1.7	-1.1	1.4	-2.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.2	0.5	0.2	-0.5	-0.2	-0.2	-0.1	0.1	-0.3
Current tobacco smoking	0.1	0.1	0.3	0.0	0.2	-0.1	-0.2	0.3	0.1	-0.6	0.4	0.4
Average weekly fortified wine intake	0.8	0.9	2.0	0.6	-1.0	-1.0	1.3	0.7	1.0	0.9	-1.4	0.1
Maternal smoking around birth	1.0	1.4	2.4	-1.5	1.4	1.2	-1.3	-0.9	-1.3	-0.7	0.9	-1.3
Fed-up feelings	0.1	0.2	1.0	0.4	0.1	-0.3	0.5	0.2	0.3	0.6	-1.0	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.3	-0.7	1.5	1.1	-1.3	-1.4	-1.2	-1.4	1.1	-1.4
Relative age voice broke	0.1	0.2	1.1	-1.0	0.2	0.5	-0.1	0.0	-0.4	0.1	0.2	-0.4
Taking other prescription medications	0.9	1.4	4.1	0.9	-1.4	-1.1	1.0	1.1	1.1	0.6	-0.7	2.0
Age when periods started (menarche)	0.3	0.6	2.9	-1.7	0.3	0.4	-0.4	-0.2	-0.4	-0.2	0.2	-1.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.6	-0.4	-0.0	0.1	0.4	0.2	-0.1	0.5	-0.4	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	8.1	1.4	-2.1	-2.2	2.3	2.1	2.2	2.8	-2.6	0.9
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	3.3	1.1	-1.5	-1.8	1.6	1.8	1.7	1.2	-1.7	1.7
Qualifications: CSEs or equivalent	0.7	0.9	3.3	-0.8	1.0	0.9	-0.7	-0.7	-0.9	-0.7	0.5	-1.8
Serious illness, injury or assault to yourself	0.9	1.2	2.6	-0.4	0.9	1.0	-1.4	-0.9	-1.0	-1.4	1.6	-0.2
High blood pressure	0.1	0.2	0.8	0.6	-0.2	-0.3	-0.0	0.3	0.2	0.1	-0.0	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.7	1.1	-1.1	-1.0	1.3	0.9	1.0	0.5	-1.0	0.9
Multivitamins +/- minerals	0.0	0.1	0.1	0.4	-0.1	-0.3	0.1	0.1	0.3	0.2	-0.3	0.0
Stomach or abdominal pain in last month	0.8	1.0	1.4	0.7	-0.9	-1.1	1.0	1.1	1.1	1.2	-1.1	0.8
Supplements: Glucosamine	0.7	0.9	1.5	0.8	-0.9	-0.8	1.0	0.8	0.9	1.1	-1.2	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	1.3	-0.8	-0.9	0.5	0.6	0.9	0.8	-0.6	1.1
Medication: Atenolol	0.2	0.2	1.4	0.5	-0.3	-0.5	0.1	0.2	0.4	0.1	-0.2	1.2
Medication: Levothyroxine sodium	0.1	0.1	0.7	-0.2	0.2	0.2	-0.0	-0.3	-0.2	-0.0	-0.0	-0.8
Sitting height	0.8	5.6	11.8	-2.7	2.1	2.1	-2.4	-2.2	-2.1	-1.5	2.1	-3.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.4	-0.2	-0.2	-0.2	-0.2	0.4	0.2	-0.0	0.1	0.6
High blood pressure (mother)	0.4	0.5	0.7	0.8	-0.8	-0.8	0.6	0.8	0.8	0.6	-0.5	0.4
Body mass index (BMI)	1.5	6.2	8.9	2.6	-2.5	-2.6	2.1	2.5	2.5	2.5	-2.2	3.0
Impedance of leg (left)	0.1	0.6	1.6	-1.3	0.6	0.8	-0.4	-0.6	-0.7	-0.8	0.5	-0.7
Leg predicted mass (left)	0.0	0.2	0.5	0.4	-0.3	-0.5	-0.0	0.3	0.4	0.7	-0.2	-0.5
Trunk fat mass	1.1	4.7	5.8	2.0	-2.4	-2.3	1.9	2.2	2.2	2.1	-1.9	2.4
Waist circumference	0.4	1.4	3.0	1.4	-1.2	-1.2	0.8	1.2	1.1	1.1	-0.6	1.7
Number of incorrect matches in round	1.0	1.6	2.3	-0.9	1.2	1.5	-1.0	-1.4	-1.4	-1.0	1.3	-1.4
Past tobacco smoking	0.9	1.7	2.8	-1.4	1.1	1.2	-1.4	-1.2	-1.1	-1.6	1.7	-0.9
Alcohol usually taken with meals	0.6	1.0	1.5	0.9	-1.0	-1.2	0.9	0.9	1.1	1.2	-1.0	0.7
Nervous feelings	0.4	0.8	1.9	-0.4	1.1	0.9	-0.8	-1.4	-0.9	-1.1	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.4	0.0	1.2	0.9	-0.7	-1.1	-1.0	-0.9	0.4	-1.1
Hearing difficulty/problems with background noise	0.4	0.6	1.1	-0.1	0.6	0.7	-0.9	-1.0	-0.7	-0.9	1.1	-0.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.6	-0.8	0.3	0.4	0.2	-0.4	-0.4	-0.5	-0.3	-1.3
Had menopause	0.5	0.7	1.6	-0.5	0.5	1.0	-0.4	-0.9	-0.9	-1.2	0.9	-0.7
Had other major operations	2.0	2.4	2.9	-1.4	1.6	1.6	-1.4	-1.7	-1.6	-1.4	1.4	-1.7
Forced vital capacity (FVC)	0.2	0.7	3.2	-1.1	0.3	0.3	0.1	-0.3	-0.3	1.1	-0.8	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	9.2	1.9	-2.2	-2.5	2.3	2.4	2.4	3.0	-2.9	1.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.7	0.1	-0.1	-0.4	-0.2	0.4	0.3	-0.2	0.1	0.8
Qualifications: None of the above	0.4	0.8	1.3	-0.6	0.9	0.7	-1.0	-0.8	-0.8	-1.0	1.1	-0.9
Financial difficulties in last 2 years	0.2	0.3	0.9	0.6	0.0	-0.4	0.2	0.4	0.3	1.0	-0.5	0.7
Mouth/teeth dental problems	0.3	0.4	1.2	0.1	-0.9	-0.6	0.5	1.1	0.7	0.4	-0.4	0.2
Heart attack	0.2	0.2	0.5	0.3	-0.3	-0.4	0.3	0.4	0.4	0.7	-0.7	0.6
Allergy	0.0	0.1	0.3	0.0	0.1	-0.2	-0.3	0.2	0.1	0.2	-0.1	0.5
Pain all over the body in last month	0.1	0.1	0.1	0.2	-0.2	-0.2	0.3	0.4	0.2	0.3	-0.2	0.1
Diabetes (self-reported)	0.1	0.2	1.0	0.2	0.2	-0.1	-0.4	-0.3	-0.0	-0.3	0.3	1.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	0.2	-0.7	-0.5	0.3	0.6	0.5	0.3	-0.2	0.2
Medication: Ramipril	1.1	1.5	1.8	-1.3	1.3	1.3	-1.1	-1.1	-1.3	-1.0	0.9	-1.4
Medication: Simvastatin	0.1	0.2	0.8	0.6	-0.2	-0.3	0.2	0.2	0.2	0.5	-0.2	0.9
Fluid intelligence score	0.1	0.1	0.5	-0.1	0.2	-0.0	-0.6	0.1	-0.0	-0.3	0.7	0.2
Illnesses of siblings	0.0	0.0	0.1	-0.4	0.2	-0.1	0.2	-0.2	0.0	-0.2	-0.3	-0.0
Neuroticism score	0.1	0.2	0.7	0.7	0.4	-0.2	0.1	-0.3	0.1	0.2	-0.8	0.2
Weight	0.2	1.1	2.2	0.8	-1.2	-1.2	0.7	1.2	1.1	1.5	-1.0	0.7
Impedance of arm (right)	0.0	0.1	0.8	0.0	-0.3	0.1	0.3	-0.0	0.0	-0.2	0.1	-0.9
Arm fat percentage (right)	2.3	8.9	11.2	3.0	-3.2	-3.0	2.8	3.1	3.0	2.8	-2.6	3.4
Trunk fat-free mass	0.2	1.3	3.8	-1.4	1.1	0.8	-1.3	-0.9	-0.9	-0.2	0.8	-1.9
Hip circumference	0.5	2.0	3.4	1.4	-1.5	-1.6	1.0	1.6	1.5	1.8	-1.2	1.0
Time employed in main current job	1.3	1.5	2.3	0.6	-1.5	-1.2	1.4	1.2	1.3	1.2	-1.3	0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.6	0.4	0.3	-0.5	-0.4	-0.3	0.1	0.4	0.1
Father’s age at death	1.4	1.9	2.7	1.1	-1.6	-1.4	1.6	1.2	1.4	1.5	-1.5	1.1
Worrier / anxious feelings	0.1	0.1	0.4	0.2	0.4	0.1	0.1	-0.5	-0.2	0.4	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	5.6	-1.4	2.2	1.9	-2.1	-2.1	-2.0	-2.4	1.9	-1.1
Falls in the last year	1.0	1.3	3.6	-1.1	1.0	1.1	-1.1	-1.1	-1.1	-1.9	1.1	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.7	0.5	-0.4	-0.2	0.2	0.4	0.3	0.9	-0.2	0.5
Number of live births	0.1	0.1	0.3	0.4	-0.5	-0.3	0.6	0.4	0.3	0.2	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.5	-0.7	0.0	0.0	0.3	-0.0	-0.0	1.2	-0.8	-1.0
Pulse rate	0.2	0.3	0.9	0.2	-0.6	-0.4	0.6	0.9	0.5	0.7	-0.4	0.6
Happiness	5.3	6.5	7.3	-2.7	2.7	2.5	-2.6	-2.7	-2.6	-2.6	2.4	-1.9
Noisy workplace	0.0	0.1	0.2	0.3	0.3	0.1	-0.0	-0.2	-0.1	0.1	-0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	0.9	-0.7	-0.4	0.9	0.3	0.5	0.6	-1.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.8	-0.3	-0.7	0.5	0.4	0.6	0.3	-0.6	0.8
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.7	0.1	-0.0	0.4	-0.2	0.0	0.3	-0.4	0.8
Asthma	0.1	0.2	0.4	0.4	-0.5	-0.5	0.7	0.5	0.5	0.5	-0.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.2	-0.0	0.0	0.1	0.0	0.3
Medication: Cholesterol lowering	3.5	5.5	7.5	2.7	-2.3	-2.4	1.9	2.4	2.3	2.5	-2.0	2.5
Depression (self-reported)	0.0	0.1	0.2	-0.3	0.1	0.3	0.1	-0.2	-0.2	0.2	-0.2	-0.5
Medication: Lansoprazole	0.2	0.2	1.0	0.5	0.0	0.0	-0.1	-0.5	-0.0	-0.6	0.1	1.0
Prospective memory result	1.9	2.3	5.2	2.1	-1.3	-1.2	1.3	1.2	1.3	2.3	-1.3	1.1
Lung cancer (father)	0.6	0.7	2.1	-0.9	0.5	0.5	-0.9	-0.6	-0.5	-1.2	1.4	0.6
Illnesses of mother	0.1	0.2	0.8	-0.7	0.0	0.2	0.1	-0.1	-0.2	-0.0	0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.2	-1.0	0.6	0.5	-0.1	-0.6	-0.5	0.5	-0.4	-1.1
Pulse wave Arterial Stiffness index	0.2	0.2	1.0	0.3	-0.3	-0.3	0.5	0.4	0.3	0.1	-0.6	1.0
Impedance of arm (left)	0.0	0.1	0.4	-0.1	-0.2	0.1	0.3	-0.1	0.0	-0.4	0.1	-0.6
Arm fat mass (right)	1.3	5.2	5.8	2.2	-2.4	-2.4	2.0	2.4	2.3	2.4	-2.0	2.4
Trunk predicted mass	0.2	1.4	4.0	-1.5	1.1	0.9	-1.4	-0.9	-1.0	-0.2	0.8	-2.0
Standing height	0.9	8.8	22.9	-3.5	2.6	2.7	-2.7	-2.7	-2.7	-1.8	2.2	-4.8
Length of working week for main job	0.9	1.0	1.9	-0.4	1.1	0.9	-1.1	-1.1	-0.9	-1.4	1.1	-0.6
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.6	-0.2	-0.3	-0.1	0.4	0.3	0.1	0.2	0.0
Breastfed as a baby	0.9	1.1	3.1	-1.1	1.0	1.1	-0.7	-1.3	-1.1	-0.3	0.6	-1.8
Tense / ‘highly strung’	0.0	0.1	0.2	-0.2	0.3	0.1	-0.2	-0.3	-0.2	-0.5	-0.0	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.7	0.3	0.3	0.0	0.1	-0.3	0.3	-0.3	-0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.9	0.4	-0.3	-0.5	0.4	0.3	0.4	0.3	-0.4	0.9
Birth weight of first child	0.1	0.1	0.2	-0.5	0.4	0.4	-0.3	-0.3	-0.4	0.3	0.0	-0.3
Peak expiratory flow (PEF)	0.2	0.4	1.1	0.1	-0.3	-0.5	0.6	0.5	0.4	1.0	-0.9	-0.7
Pulse wave reflection index	1.6	1.9	3.6	0.9	-1.3	-1.4	1.5	1.3	1.4	0.9	-1.7	1.9
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.3	1.2	-0.6	-1.1	1.1	0.7	0.9	1.2	-1.5	0.7
Loud music exposure frequency	0.2	0.2	0.4	0.5	0.6	0.3	-0.5	-0.6	-0.3	-0.3	0.4	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.9	1.2	-1.2	-1.1	1.5	1.0	1.1	1.2	-1.7	1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	-0.4	1.1	0.7	-0.9	-1.2	-0.8	-0.6	0.5	-0.6
Blood clot in the leg (DVT)	3.9	5.0	8.0	-2.3	2.1	2.3	-2.2	-2.1	-2.3	-1.6	2.3	-2.8
Medication: Paracetamol	0.2	0.3	0.6	-0.3	0.8	0.4	-0.7	-0.6	-0.5	-0.8	0.4	-0.3
Headache pain in last month	0.1	0.2	0.9	-0.3	0.5	0.2	-0.3	-0.1	-0.3	-0.2	-0.2	-1.0
Medication for cholesterol, blood pressure or diabetes	3.8	6.2	8.8	-3.0	2.3	2.5	-2.0	-2.5	-2.5	-2.4	2.2	-2.9
Glaucoma (self-reported)	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.1	0.3	0.2	0.1	-0.1	-0.1
Gout (self-reported)	0.4	0.5	0.9	0.4	-0.6	-0.6	0.8	0.8	0.7	1.0	-0.9	0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.4	0.2	-0.0	0.1	-0.2	-0.1	-0.1	0.5	0.3	-0.6
Medication: Amlodipine	0.4	0.6	2.1	1.4	-0.5	-0.8	0.5	0.6	0.8	0.3	-0.5	1.0
Medication: Ventolin 100micrograms inhaler	2.5	3.2	4.4	1.4	-1.6	-2.0	1.6	2.1	1.9	1.8	-1.7	1.9
Birth weight	0.6	1.2	4.5	-1.5	1.0	0.8	-0.9	-0.6	-0.8	-0.4	0.7	-2.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.9	0.7	0.6	-0.4	-0.4	-0.7	-0.1	0.2	-0.9
High blood pressure (siblings)	0.2	0.3	0.5	0.6	-0.6	-0.4	0.3	0.7	0.4	0.6	-0.2	0.5
Forced vital capacity (FVC), Best measure	0.2	0.9	3.3	-1.2	0.9	0.7	-0.4	-0.8	-0.7	0.5	-0.3	-1.8
Body fat percentage	2.0	7.8	11.7	2.7	-3.0	-2.8	2.5	2.8	2.8	2.5	-2.4	3.4
Leg fat percentage (right)	2.2	7.9	15.3	2.5	-3.0	-2.8	2.4	2.9	2.8	2.5	-2.3	3.9
Arm fat-free mass (right)	0.1	0.6	1.2	-1.1	0.8	0.6	-1.0	-0.6	-0.7	-0.2	0.6	-1.1
Exposure to tobacco smoke outside home	0.8	1.0	1.3	-0.8	1.2	1.0	-1.1	-0.9	-1.0	-0.9	1.1	-1.0
Comparative body size at age 10	0.6	1.6	3.4	1.6	-1.0	-1.3	1.1	1.3	1.2	1.9	-1.4	0.3
Number of full brothers	0.2	0.3	0.6	-0.2	-0.5	-0.5	0.7	0.8	0.5	0.3	-0.7	0.1
Worry too long after embarrassment	0.1	0.2	0.6	0.6	-0.3	-0.4	0.5	0.2	0.4	0.3	-0.8	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.7	-1.3	0.7	0.9	-0.8	-1.0	-0.8	-0.9	1.0	0.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.5	-0.8	0.9	0.8	-1.1	-0.6	-0.8	-1.6	1.5	-0.2
Number of children fathered	0.1	0.1	0.2	0.2	-0.3	-0.3	0.3	0.4	0.3	0.5	-0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.0	-1.0	0.9	1.3	-0.8	-1.0	-1.2	-0.3	0.8	-2.0
Age at first live birth	2.7	4.8	7.1	2.0	-2.2	-2.1	2.6	1.8	2.1	2.1	-2.7	2.1
Pulse wave peak to peak time	0.5	0.6	2.1	-0.7	0.6	0.5	-0.7	-0.6	-0.5	-0.3	0.7	-1.5
Health satisfaction	0.2	0.2	0.4	0.3	-0.4	-0.6	0.4	0.6	0.5	0.5	-0.4	0.3
Shortness of breath walking on level ground	1.0	1.2	1.8	1.0	-1.0	-1.1	0.9	1.1	1.1	0.9	-1.2	1.4
Qualifications: College or University degree	0.4	1.1	3.8	-1.4	0.9	1.0	-0.6	-0.7	-1.0	-0.5	0.6	-2.0
Eye problems/disorders: None of the above	0.4	0.4	0.8	0.9	-0.7	-0.7	0.4	0.6	0.7	0.8	-0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	-1.2	0.8	0.9	-0.8	-0.6	-0.9	-0.8	0.8	-0.7
Emphysema/chronic bronchitis	1.2	1.3	2.1	-0.7	0.9	1.2	-1.0	-1.4	-1.2	-1.2	1.4	-1.0
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	-0.0	-0.7	-0.6	0.9	0.7	0.6	0.6	-0.9	0.2
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.6	0.6	0.7	-0.6	-0.5	-0.7	-0.0	0.6	-0.6
Medication: Blood pressure	0.4	0.8	2.1	1.3	-0.7	-0.8	0.3	0.8	0.8	0.6	-0.5	1.5
Angina (self-reported)	0.3	0.3	0.7	-0.4	0.8	0.5	-0.8	-0.5	-0.6	-0.6	0.5	0.3
Migraine (self-reported)	2.0	2.4	3.5	1.0	-1.8	-1.6	1.6	1.9	1.6	1.8	-1.5	0.9
Medication: Ibuprofen	0.0	0.0	0.2	0.2	0.1	0.0	-0.5	-0.1	-0.0	0.1	0.3	0.1
Medication: Allopurinol	1.2	1.5	2.0	1.3	-1.3	-1.2	1.2	1.4	1.2	1.4	-1.1	1.0
Medication: Omeprazole	0.1	0.1	0.5	-0.4	0.1	0.0	-0.6	0.1	-0.1	-0.4	0.7	0.4
Medication: Seretide 50 evohaler	0.1	0.2	0.7	0.3	0.0	-0.0	0.5	-0.3	0.0	-0.5	-0.3	0.8
Mean time to correctly identify matches	0.1	0.2	0.9	0.4	0.4	0.3	-0.4	-1.0	-0.3	-0.3	0.4	0.1
Heart disease (mother)	1.7	2.1	3.0	-1.3	1.7	1.6	-1.5	-1.5	-1.6	-1.5	1.4	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.0	0.8	-0.9	-1.2	1.2	1.2	1.1	0.9	-1.4	1.2
Whole body fat mass	1.1	4.7	6.2	2.0	-2.3	-2.2	1.9	2.2	2.2	2.1	-1.9	2.5
Leg fat mass (right)	1.2	4.8	7.5	2.0	-2.3	-2.2	1.9	2.3	2.2	2.1	-1.9	2.7
Arm predicted mass (right)	0.1	0.7	1.2	-0.9	0.9	0.7	-1.1	-0.8	-0.8	-0.2	0.6	-1.1
Pulse rate, automated reading	0.2	0.5	1.0	-1.0	0.9	0.8	-0.5	-0.4	-0.8	-1.0	0.6	-0.1
Alcohol intake frequency.	0.1	0.2	0.5	0.3	0.6	-0.0	-0.2	-0.1	-0.1	0.5	-0.3	-0.7
Comparative height size at age 10	0.2	1.3	5.7	-1.1	0.8	0.9	-1.0	-0.9	-0.9	-0.5	1.0	-2.4
Number of full sisters	1.2	1.5	2.7	-1.1	1.2	1.2	-1.4	-1.4	-1.2	-0.9	1.6	-0.7
Suffer from ‘nerves’	0.7	1.1	1.8	-1.1	1.3	1.0	-1.1	-1.3	-1.1	-1.0	0.5	-0.7
Overall health rating	0.0	0.0	0.1	0.3	0.1	-0.0	-0.0	0.1	0.0	0.1	0.0	-0.0
Chest pain or discomfort	0.4	0.6	2.4	0.4	-0.6	-0.8	0.1	1.0	0.8	-0.4	-0.1	1.6
Had major operations	3.4	3.9	6.1	1.7	-1.8	-2.0	2.2	1.8	2.0	2.0	-2.5	1.8
Age at last live birth	0.1	0.1	0.3	-0.1	-0.0	0.1	0.6	-0.1	-0.1	-0.1	-0.5	-0.1
Family relationship satisfaction	0.2	0.3	0.9	-0.2	0.7	0.4	-0.6	-1.0	-0.5	-0.5	0.3	0.3
Leg pain on walking	0.0	0.1	0.2	0.2	0.4	0.2	-0.2	-0.2	-0.2	-0.1	-0.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.5	0.7	0.5	-0.5	-0.6	-0.6	-0.6	0.4	-0.8
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.8	1.2	-1.1	-1.1	1.1	1.0	1.1	1.4	-1.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	-0.4	-0.6	-0.2	0.6	0.3	0.3	0.3	-0.4	-0.7
Medication: Aspirin	0.1	0.1	0.3	0.5	0.1	0.2	-0.3	-0.2	-0.2	0.1	0.6	-0.2
Supplements: Vitamin C	0.1	0.1	0.4	-0.3	0.2	0.1	-0.4	0.1	-0.1	-0.3	0.3	-0.6
Knee pain experienced in last month	0.1	0.2	0.5	-0.2	0.5	0.6	-0.7	-0.6	-0.6	-0.0	0.5	0.0
Hypertension (Self-reported)	0.0	0.1	0.7	0.5	0.0	-0.1	-0.2	0.1	0.0	-0.1	0.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	-1.1	0.6	0.8	-0.8	-1.0	-0.8	-1.1	0.7	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.1	0.3	0.3	-0.1	-0.4	-0.3	-0.2	0.0	-0.6
Illnesses of siblings: Diabetes	0.7	0.8	1.5	0.4	-0.9	-0.9	0.8	1.2	0.9	1.2	-0.9	0.2
Smoking status: Previous	0.9	1.3	2.2	1.2	-1.0	-1.0	1.1	0.9	1.0	1.4	-1.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	-0.1	-0.3	-0.5	0.6	0.3	0.5	1.0	-1.0	-0.3
Whole body fat-free mass	0.1	0.4	1.7	-0.7	0.6	0.3	-0.8	-0.5	-0.4	0.2	0.4	-1.3
Leg fat-free mass (right)	0.0	0.1	0.5	0.1	0.0	-0.2	-0.3	-0.0	0.1	0.5	-0.0	-0.7
Arm fat percentage (left)	2.2	8.9	12.4	3.0	-3.1	-3.0	2.7	3.0	3.0	2.7	-2.6	3.5
Average weekly red wine intake	0.7	1.1	2.4	0.4	-1.1	-1.0	1.1	1.1	1.0	1.6	-1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.7	0.2	0.1	0.1	-0.2	-0.1	-0.1	-0.3	0.2	0.8
Mood swings	0.2	0.3	0.8	0.9	-0.1	-0.5	0.4	0.2	0.4	0.6	-0.8	0.7
Loneliness, isolation	0.6	0.9	1.8	-0.9	1.3	0.8	-1.1	-0.8	-1.0	-0.5	0.4	-1.2
Long-standing illness, disability or infirmity	0.4	0.5	1.1	0.9	-0.5	-0.8	0.5	0.7	0.7	0.6	-0.8	1.0
Ever had bowel cancer screening	0.8	1.0	1.5	-1.1	0.9	1.0	-0.7	-1.2	-1.0	-1.2	0.8	-1.0
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.0	0.5	0.1	-0.5	-0.4	-0.2	-0.4	0.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	-0.7	0.3	0.4	-0.2	-0.2	-0.3	-0.2	0.2	0.1
Friendships satisfaction	2.1	2.6	3.1	-1.7	1.8	1.6	-1.5	-1.7	-1.6	-1.7	1.3	-1.7
Qualifications: nursing, teaching	0.1	0.2	1.4	0.3	-0.2	-0.2	0.1	0.3	0.2	0.3	-0.2	1.2
Commuting to job workplace: Walk	6.5	7.0	8.3	-2.4	2.9	2.4	-2.8	-2.7	-2.6	-2.9	2.4	-2.6
Eye problems/disorders: Cataract	2.2	2.5	4.4	-2.1	1.5	1.5	-1.4	-1.3	-1.5	-1.9	1.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	0.5	-0.6	-0.6	0.7	0.5	0.6	0.4	-0.5	0.4
Medication for cholesterol	0.0	0.0	0.2	-0.4	0.0	-0.1	-0.2	0.1	0.1	0.2	0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-0.9	1.2	0.7	-0.6	-0.9	-0.8	-0.9	0.3	-0.4
Back pain experienced in last month	0.1	0.1	0.4	-0.1	0.2	0.1	-0.6	-0.2	-0.2	0.1	0.4	0.5
Mineral and other dietary supplements	0.1	0.2	0.6	-0.0	0.3	0.3	-0.6	-0.3	-0.3	-0.4	0.8	-0.1
Breast cancer (self-reported)	0.2	0.2	0.5	0.4	0.3	0.2	-0.5	-0.5	-0.3	-0.6	0.6	0.7
Asthma (self-reported)	0.1	0.1	0.3	0.2	-0.4	-0.2	0.6	0.3	0.3	0.4	-0.2	0.3
Osteoporosis (self-reported)	1.9	2.3	3.5	-1.0	1.5	1.6	-1.6	-1.9	-1.6	-1.5	1.9	-0.9
Osteoarthritis (self-reported)	0.9	1.2	3.1	-1.2	1.1	1.2	-0.6	-1.3	-1.2	-0.4	0.3	-1.8
Medication: Aspirin	0.1	0.2	0.6	0.5	0.1	0.3	-0.5	-0.4	-0.3	-0.1	0.8	-0.2
Medication: Gliclazide	0.2	0.2	1.1	-0.2	-0.3	-0.4	0.2	0.7	0.4	1.0	-0.4	0.1
Illnesses of father: None of the above (group 1)	1.2	1.5	1.9	-1.0	1.3	1.3	-1.3	-1.4	-1.3	-1.3	1.3	-0.4
Smoking status: Current	0.0	0.1	0.2	-0.1	0.2	-0.2	-0.2	0.4	0.1	-0.4	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.5	0.2	0.4	-0.3	-0.5	-0.4	-0.1	0.2	-0.3
Whole body water mass	0.1	0.5	2.1	-0.8	0.6	0.4	-0.9	-0.6	-0.5	0.1	0.4	-1.4
Leg predicted mass (right)	0.0	0.1	0.6	0.2	0.0	-0.2	-0.2	-0.0	0.1	0.6	-0.0	-0.8
Arm fat mass (left)	1.1	4.7	5.8	2.1	-2.3	-2.3	1.9	2.3	2.2	2.2	-1.9	2.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.7	0.1	-0.2	-0.0	-0.1	-0.0	0.1	-0.5	0.2	0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.7	1.0	0.8	-0.7	-0.9	-0.8	-1.1	0.7	-0.6
Miserableness	0.1	0.1	0.6	0.4	0.2	-0.3	0.2	-0.0	0.2	0.3	-0.8	0.1
Guilty feelings	0.1	0.2	0.4	0.6	0.1	-0.4	-0.0	0.2	0.3	0.5	-0.5	0.5
Wears glasses or contact lenses	0.1	0.1	0.3	0.1	0.4	0.3	-0.4	-0.2	-0.3	-0.6	0.5	0.3
Ever taken oral contraceptive pill	4.0	4.5	5.7	2.0	-2.4	-2.2	2.2	2.0	2.3	1.9	-2.0	2.0
Hearing aid user	0.9	1.0	1.6	0.7	-1.1	-1.1	0.9	1.3	1.1	0.5	-0.9	1.1
Mother’s age at death	0.3	0.4	1.3	0.1	-0.6	-0.3	1.1	0.5	0.4	0.6	-1.0	0.5
Financial situation satisfaction	0.9	1.1	2.8	1.4	-0.7	-1.0	0.7	0.7	0.9	1.0	-0.9	1.7
Tinnitus: Yes, now most or all of the time	3.7	4.3	5.4	-1.4	2.3	2.2	-1.9	-2.3	-2.2	-2.1	1.9	-2.1
Commuting to job workplace: Public transport	0.5	0.6	1.0	-0.6	0.9	0.7	-0.7	-1.0	-0.8	-0.9	0.7	-0.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.5	0.7	0.8	-0.8	-0.8	-0.8	-0.6	0.8	-1.1
Medication: Blood pressure	0.2	0.4	0.9	-0.2	0.6	0.7	-0.7	-0.6	-0.6	-0.9	0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.3	0.3	0.5	-0.3	-0.4	-0.4	-0.0	0.1	-0.6
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.3	-0.3	0.2	0.0	0.2	-0.0	-0.0	-0.0	-0.5	-0.4
High cholesterol (Self-reported)	0.0	0.1	0.5	-0.0	0.0	0.2	0.3	-0.1	-0.1	0.7	-0.3	0.1
Medication: Bendroflumethiazide	0.3	0.5	1.8	-0.0	0.4	0.5	-0.8	-0.4	-0.5	-1.3	1.0	0.4
Medication: Paracetamol	0.2	0.3	0.5	-0.4	0.7	0.5	-0.7	-0.6	-0.5	-0.6	0.5	-0.4
Medication: Lisinopril	0.9	1.2	2.6	1.5	-1.3	-1.1	0.3	1.0	1.1	0.9	-0.2	1.6
Medication: Atorvastatin	0.1	0.1	0.4	0.5	-0.3	-0.2	0.2	0.3	0.3	0.4	0.0	0.6
Illnesses of father: High blood pressure	0.1	0.1	0.4	0.2	-0.4	-0.5	0.1	0.4	0.5	0.2	-0.1	0.6
Alcohol drinker status: Never	0.2	0.2	0.3	0.4	-0.4	-0.5	0.6	0.5	0.5	-0.2	-0.4	0.4
Ever smoked	1.1	2.0	3.0	1.7	-1.1	-1.4	1.6	1.3	1.3	1.6	-1.7	0.8
Basal metabolic rate	0.0	0.2	0.8	-0.3	0.1	-0.1	-0.4	-0.0	-0.0	0.6	-0.0	-0.9
Leg fat percentage (left)	2.1	7.5	14.4	2.4	-2.8	-2.7	2.4	2.8	2.7	2.5	-2.4	3.8
Arm fat-free mass (left)	0.1	0.6	1.4	-0.9	0.8	0.6	-1.0	-0.6	-0.7	-0.1	0.5	-1.2
Number of operations (self-reported)	0.1	0.1	0.3	0.3	-0.4	-0.4	0.2	0.2	0.4	0.5	-0.3	0.6
Average weekly beer plus cider intake	0.1	0.1	0.2	0.2	0.3	0.2	-0.1	-0.3	-0.2	-0.4	0.2	0.4
Irritability	0.1	0.2	1.0	-0.3	0.7	0.2	-0.1	-0.3	-0.3	0.1	-0.5	-1.0
Risk taking	0.6	0.9	1.6	-1.0	1.0	0.8	-1.3	-0.8	-0.8	-1.0	1.2	-0.5
Ever had prostate specific antigen (PSA) test	1.7	2.0	2.8	1.1	-1.7	-1.4	1.5	1.7	1.5	1.2	-1.2	1.4
Fractured/broken bones in last 5 years	0.9	1.2	3.5	-0.8	0.9	0.7	-1.3	-1.0	-0.8	-1.9	1.4	-0.3
Age started oral contraceptive pill	1.3	1.6	2.3	1.0	-1.4	-1.2	1.5	1.4	1.2	1.0	-1.3	1.2
Diastolic blood pressure, automated reading	0.1	0.4	1.2	0.1	0.5	0.6	-0.5	-0.8	-0.6	-1.1	0.6	0.4
Ever depressed for a whole week	0.1	0.2	0.6	-0.8	0.4	0.4	-0.4	-0.1	-0.4	-0.4	0.3	-0.0
Unable to work because of sickness or disability	0.5	0.7	1.8	1.4	-0.7	-0.7	0.5	0.7	0.7	0.7	-0.2	1.3
Commuting to job workplace: Cycle	0.1	0.1	0.5	0.7	-0.1	-0.3	0.1	0.2	0.2	0.1	-0.3	0.1
Myopia	0.1	0.1	0.2	-0.4	0.4	0.4	-0.3	-0.5	-0.4	-0.4	0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.8	-0.4	-0.0	0.1	0.2	-0.1	-0.0	0.1	-0.0	-0.9
Cholesterol lowering medication	0.4	0.5	1.0	-1.0	0.7	0.9	-0.3	-0.8	-0.8	-0.8	0.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	0.0	-0.3	-0.2	-0.1	0.2	0.2	-0.3	0.5	0.7
Pain experienced in last month	0.1	0.2	0.4	0.4	-0.4	-0.4	0.7	0.2	0.5	-0.1	-0.3	0.2
Supplements: Calcium	0.2	0.2	0.5	-0.2	0.4	0.4	-0.4	-0.4	-0.4	-0.7	0.7	-0.6
Basal cell carcinoma (self-reported)	2.3	2.8	5.0	-2.0	1.6	1.5	-1.7	-1.3	-1.5	-2.2	1.7	-1.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.1	-0.1	-0.2	0.1	0.2	0.2	0.3	-0.4	0.5
Deep venous thrombosis (DVT) (self-reported)	5.3	6.8	9.6	-2.6	2.5	2.7	-2.5	-2.5	-2.6	-2.0	2.8	-3.1
Heart disease (siblings)	0.1	0.2	0.3	-0.1	0.4	0.5	-0.5	-0.5	-0.5	-0.3	0.4	-0.3
Alcohol drinker status: Previous	0.9	1.0	3.6	-0.5	1.2	1.0	-0.6	-1.0	-1.0	-0.1	0.1	-1.9
Pack years of smoking	0.4	0.7	1.2	-0.5	0.9	0.8	-0.7	-0.9	-0.8	-1.1	0.9	-0.6
Impedance of whole body	0.0	0.1	0.4	-0.5	0.1	0.3	0.1	-0.2	-0.2	-0.5	0.2	-0.6
Leg fat mass (left)	1.3	4.9	7.2	2.0	-2.3	-2.3	1.9	2.3	2.2	2.2	-2.0	2.7
Arm predicted mass (left)	0.1	0.5	1.3	-1.0	0.7	0.5	-0.9	-0.5	-0.6	-0.0	0.5	-1.1