Hub : Genes

TSHR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.108	0.0300	2.6e-06	0.102	0.058	0.095	0.091	0.096	2.1e-12	1.4e-07	1.3e-11	3.9e-11	9.4e-12
2	METSIM	Adipose	0.135	0.0308	1.1e-09	0.080	0.065	0.114	0.094	0.103	4.6e-12	5.3e-10	1.3e-16	6.8e-14	4.0e-15
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.174	0.0490	9.3e-10	0.099	0.086	0.097	NA	0.114	3.4e-11	6.1e-10	5.4e-11	NA	8.7e-13
4	TCGA	Thyroid Carcinoma	0.089	0.0400	1.6e-03	0.025	0.014	0.020	NA	0.024	1.7e-03	1.5e-02	4.4e-03	NA	1.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.6	0.5	0.8	-0.1	-0.1
Bipolar Disorder or Schizophrenia	1.4	3.3	6.5	-2.5	1.7	-0.5	1.9
Depressed Affect (Nagel 2018)	1.1	2.4	5.8	2.4	-0.2	-1.3	-1.4
Depression (Nagel 2018)	0.4	0.6	2.4	0.4	0.1	-1.5	-0.2
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.6	1.6	-1.0	0.1	-1.6
Neuroticism (Nagel 2018)	0.7	1.7	3.1	1.4	-0.0	-1.8	-1.4
Schizophrenia (2018)	2.7	5.7	13.7	-3.7	1.6	-0.6	2.5
Schizophrenia vs Biploar Disorder	2.4	3.2	9.7	-3.1	0.9	-0.6	1.4
Worry (Nagel 2018)	0.3	0.7	1.7	0.4	0.0	-1.0	-1.3
Alzheimer’s Disease (in mother)	1.6	1.8	3.5	1.9	-0.1	0.7	-1.8
Alzheimer’s Disease (in father)	2.5	2.7	5.8	0.6	-1.4	-2.4	-1.6
Alzheimer’s Disease (including proxy)	0.7	1.1	2.6	1.0	-0.8	-0.2	-1.6
Crohns Disease (2017)	0.6	1.4	3.1	1.8	1.5	0.3	-0.1
Irritable Bowel Disease (IBD)	0.8	2.0	5.7	2.4	1.5	-0.0	-0.0
Ulcerative Colitis (UC)	0.7	1.4	3.7	1.9	1.3	-0.3	0.4
Major Depression (MDD)	0.4	0.4	0.8	-0.9	0.6	-0.6	-0.5
Reaction Time	1.4	2.7	5.4	-0.8	1.2	-1.8	2.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.0	0.5	-1.6	-0.0	-1.7
Breast Cancer	0.7	1.6	5.8	-0.4	-0.5	0.4	2.4
Ovarian Cancer	0.1	0.1	0.2	-0.4	-0.0	0.1	0.4
Prostate Cancer	0.8	1.1	2.2	0.8	-1.5	0.6	1.0
Age at First Birth	0.4	0.6	1.3	1.2	-0.6	0.7	-0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	0.0	-0.4	-0.0	-0.2
Body Mass Index (BMI) (2010)	0.8	1.1	1.9	-1.1	1.1	0.4	1.4
Coronary Artery Disease (CAD)	0.3	0.4	1.4	-0.3	-0.0	1.2	-0.4
Crohns Disease (2012)	0.7	1.2	2.2	1.5	1.0	-1.2	-0.0
Mean Putamen Volume	1.8	2.0	5.7	1.0	-2.4	-0.6	-1.0
Fasting Glucose	1.1	1.3	4.5	-0.0	2.1	-0.1	0.8
HbA1C	2.1	2.3	5.0	1.1	-0.6	-2.2	-1.7
HDL Cholesterol	0.7	1.1	2.6	-1.0	-0.5	-0.8	1.6
LDL Cholesterol	0.4	0.6	1.2	-1.1	-1.1	0.1	-0.2
Lupus	0.3	0.5	1.7	-0.2	0.1	1.3	-0.6
Neuroticism (2016)	0.2	0.3	0.6	0.8	-0.1	-0.4	-0.6
Primary Biliary Cirrhosis	0.7	0.9	1.4	-0.9	1.2	-1.0	-0.8
Rheumatoid Arthritis	0.9	1.2	4.2	-2.0	0.7	0.3	0.3
Schizophrenia (2014)	2.9	6.5	19.0	-4.4	1.1	-1.4	1.9
Triglycerides	0.1	0.2	0.7	-0.1	-0.8	0.2	0.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	5.0	-0.4	-0.6	2.2	0.0
Ulcerative Colitis	0.7	1.0	2.0	1.2	1.4	-0.7	0.4
Blood Eosinophil Count	0.6	4.5	12.4	-3.5	-0.5	-2.0	-1.2
Blood Platelet Count	0.1	1.2	1.6	-1.2	-1.2	-0.5	-1.2
Blood Red Count	1.1	10.7	30.9	-5.6	-1.7	-2.0	2.3
Blood White Count	1.6	12.1	40.6	-6.4	-1.2	-2.4	0.7
Heel T-Score	0.4	3.6	7.8	2.8	1.2	2.1	0.8
BMI	0.5	2.7	8.6	2.9	-1.0	-0.9	-0.3
Height	0.1	1.4	3.5	-1.2	-0.7	1.9	0.5
Waist Hip Ratio (WHR)	0.1	0.5	1.5	-0.7	-0.1	-1.2	0.0
Systolic Blood Pressure	0.1	0.4	0.6	0.7	-0.5	0.3	0.7
Smoking Status	0.6	1.4	4.7	0.5	-2.2	0.3	0.7
Allergy or Eczema	2.8	7.3	20.5	4.5	-0.0	-0.5	-2.9
Cardiovascular Disease	0.4	1.4	2.3	1.4	-0.2	-1.5	-1.1
Hypothyroidism (self reported)	1.6	3.6	5.3	2.0	2.0	-1.0	-2.3
Respiratory disease	0.4	0.8	2.3	0.9	0.2	-1.5	-0.4
Type 2 Diabetes (T2D) (2018)	1.2	2.3	3.0	1.7	-1.6	-1.5	-1.2
Lung FEV1/FVC ratio	0.5	2.8	7.8	2.8	1.0	1.3	-0.7
Lung FVC	0.3	1.6	3.0	1.7	-0.8	1.6	0.5
Neuroticism	0.8	2.0	3.0	1.7	1.0	-1.7	-1.1
Chronotype (morning person)	0.8	2.0	3.9	-1.5	-2.0	-1.3	0.3
Hair Pigment	0.1	2.4	6.4	-2.5	-1.4	-0.8	0.8
Tanning	0.2	2.2	6.8	2.6	-1.2	-0.1	-0.6
Hand grip strength (left)	0.6	1.7	5.1	1.2	-0.0	2.3	0.5
Number of treatments/medications taken	0.9	1.6	3.2	1.8	0.2	-1.8	0.2
Average weekly spirits intake	0.3	0.4	1.0	-0.5	-0.7	-0.1	-1.0
Sensitivity / hurt feelings	0.2	0.3	0.9	0.4	-0.3	-0.5	-0.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.0	0.6	0.3	-1.7	-0.9
Hearing difficulty/problems: Yes	0.5	0.8	1.6	0.9	-1.3	0.0	-0.9
Relative age of first facial hair	0.3	0.5	1.5	-1.2	-0.1	0.5	-0.6
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.3	2.3	-0.2	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	-1.0	1.1	0.0	1.0
Ever had hysterectomy (womb removed)	3.0	3.3	11.2	-3.3	0.1	1.4	0.5
Systolic blood pressure, automated reading	0.4	1.1	2.2	0.6	-0.2	-1.5	1.4
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	4.1	-1.5	1.8	-2.0	-1.0
Angina	1.0	1.3	2.2	-1.0	1.5	-0.5	1.3
Medication for hormone replacement therapy	0.3	0.3	1.2	-1.1	-0.1	-0.2	0.2
Vitamin and mineral supplements	2.3	3.1	6.6	-2.6	1.6	-0.8	1.7
Supplements: Zinc	1.0	1.1	2.2	1.2	-0.8	0.4	-1.5
Medication: Co-codamol	0.1	0.2	0.4	0.0	0.6	-0.3	0.4
Medication: Metformin	1.1	1.6	5.4	0.3	-0.6	-0.7	-2.3
Diabetes (father)	0.6	0.7	1.5	-1.2	0.8	-0.9	0.2
Diabetes (mother)	0.5	0.6	1.3	-0.9	0.3	1.1	-0.5
Severe depression (siblings)	0.3	0.3	0.8	0.1	0.9	-0.1	-0.6
Pack years adult smoking proportion	0.5	0.8	1.4	0.8	1.2	1.0	0.3
Impedance of leg (right)	1.0	4.9	19.3	-4.4	-0.1	-0.4	0.5
Leg fat-free mass (left)	0.7	3.5	11.3	3.4	-1.0	0.9	-1.0
Trunk fat percentage	0.1	0.5	1.1	-0.8	-1.0	-0.0	-0.4
Hand grip strength (right)	0.6	1.6	3.3	1.6	-0.7	1.8	-0.1
Townsend deprivation index at recruitment	0.4	0.5	1.3	-1.1	0.7	0.4	0.1
Current tobacco smoking	0.3	0.4	0.8	0.9	0.2	-0.2	-0.9
Average weekly fortified wine intake	0.7	0.9	2.8	-0.1	-0.5	-1.7	-0.6
Maternal smoking around birth	0.2	0.2	0.4	-0.5	0.4	-0.4	-0.6
Fed-up feelings	0.2	0.3	0.9	0.4	-0.2	-0.5	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.1	0.7	-0.7	0.2
Relative age voice broke	0.3	0.4	0.9	0.4	-0.6	0.9	-0.4
Taking other prescription medications	2.4	3.6	7.7	2.8	-0.1	-2.3	-1.2
Age when periods started (menarche)	0.1	0.3	0.7	-0.7	0.1	-0.4	-0.8
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.6	-1.6	1.5	1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.1	6.0	0.9	2.4	1.4	1.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	0.5	-0.4	-1.0	-0.3
Qualifications: CSEs or equivalent	0.4	0.6	1.7	-1.3	-0.4	0.7	-0.0
Serious illness, injury or assault to yourself	1.1	1.3	4.0	-2.0	-0.3	-0.8	0.7
High blood pressure	0.2	0.7	1.6	0.9	0.0	-1.3	-0.6
Hayfever, allergic rhinitis or eczema	2.8	6.0	19.6	4.4	-0.8	0.1	-1.9
Multivitamins +/- minerals	3.8	4.8	9.8	3.1	-1.6	1.5	-2.1
Stomach or abdominal pain in last month	1.9	2.3	5.1	-1.5	1.3	-2.3	-0.5
Supplements: Glucosamine	0.6	0.7	1.5	0.9	-1.2	0.8	0.1
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.0	0.6	-2.1	2.2	-0.2
Medication: Atenolol	0.7	0.9	3.2	-0.4	1.8	-0.3	0.4
Medication: Levothyroxine sodium	2.6	4.5	8.5	2.0	1.2	-2.9	-2.0
Sitting height	0.1	0.6	1.3	0.2	0.7	0.8	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.7	-0.0	-0.0	-1.3	0.2
High blood pressure (mother)	1.1	1.6	3.2	-1.2	1.8	1.1	0.6
Body mass index (BMI)	0.4	1.9	6.1	2.5	-1.0	0.6	-0.1
Impedance of leg (left)	1.4	6.6	24.1	-4.9	0.7	-1.2	0.5
Leg predicted mass (left)	0.7	3.6	11.3	3.4	-1.0	1.0	-1.0
Trunk fat mass	0.1	0.3	0.8	0.3	-0.9	0.5	-0.4
Waist circumference	0.1	0.4	1.5	1.2	-0.1	0.4	0.1
Number of incorrect matches in round	2.6	4.3	8.6	-2.9	-0.6	0.0	2.9
Past tobacco smoking	1.0	1.9	6.4	-0.1	2.5	0.1	-1.1
Alcohol usually taken with meals	0.8	1.3	3.9	0.7	2.0	0.9	0.0
Nervous feelings	0.3	0.6	1.5	-0.9	0.3	-0.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.7	-0.2	0.5	-1.4	-1.9
Hearing difficulty/problems with background noise	0.3	0.4	0.9	0.8	0.2	-1.0	0.0
Hair/balding pattern: Pattern 2	0.4	0.5	0.7	-0.7	-0.1	-0.9	-0.8
Had menopause	0.8	1.1	4.1	-0.2	-0.2	-2.0	0.2
Had other major operations	0.8	1.0	2.6	0.7	1.6	0.5	0.9
Forced vital capacity (FVC)	0.1	0.5	1.4	0.8	-0.0	1.2	0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	5.1	0.6	1.4	1.9	2.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-0.4	1.2	0.3	0.5
Qualifications: None of the above	0.3	0.6	1.3	-0.8	-0.4	0.3	1.1
Financial difficulties in last 2 years	0.9	1.2	2.8	0.6	0.4	-1.2	-1.7
Mouth/teeth dental problems	0.7	1.0	3.8	-0.3	-0.1	0.5	-1.9
Heart attack	0.6	0.7	1.5	0.3	0.9	0.7	1.2
Allergy	2.0	4.5	14.6	-3.8	1.2	0.0	1.4
Pain all over the body in last month	2.4	2.5	5.2	-1.3	2.3	-1.1	1.5
Diabetes (self-reported)	1.2	1.8	2.9	1.2	-0.8	-1.5	-1.7
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	5.7	2.4	-1.3	1.3	-1.6
Medication: Ramipril	0.7	0.9	2.3	0.9	0.3	0.6	-1.5
Medication: Simvastatin	0.9	1.3	2.2	0.8	1.4	-1.5	0.5
Fluid intelligence score	0.7	1.5	3.3	1.3	-0.3	1.0	-1.8
Illnesses of siblings	0.3	0.4	0.7	-0.3	-0.8	0.8	-0.2
Neuroticism score	0.4	0.9	1.8	1.4	0.2	-0.7	-1.1
Weight	0.3	1.7	5.1	2.3	-0.8	0.8	-0.5
Impedance of arm (right)	0.9	4.2	15.5	-3.9	-0.9	0.3	-0.8
Arm fat percentage (right)	0.3	1.1	2.8	0.7	-1.7	0.8	-0.7
Trunk fat-free mass	0.5	2.9	10.2	3.2	-0.4	1.2	-0.1
Hip circumference	0.2	0.9	1.8	1.3	0.1	1.3	-0.4
Time employed in main current job	1.8	2.0	3.8	-1.9	1.5	0.1	-1.5
Alcohol intake versus 10 years previously	1.2	1.9	4.4	-2.1	1.2	0.9	0.8
Father’s age at death	1.1	1.5	4.1	1.2	0.7	-2.0	-0.6
Worrier / anxious feelings	0.1	0.3	0.9	0.4	-0.3	0.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	1.1	-0.4	-0.8	-0.3
Falls in the last year	1.3	1.8	4.6	1.1	0.5	-2.1	-1.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	-0.4	0.1	0.5
Number of live births	1.9	2.6	9.9	-0.4	-0.5	-3.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.0	1.2	0.1	1.7	-1.0
Pulse rate	0.7	1.1	2.7	1.6	1.2	-0.5	0.1
Happiness	2.1	2.6	5.0	1.5	2.2	-1.7	0.1
Noisy workplace	0.5	0.6	1.2	-1.1	0.4	1.0	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.0	1.7	0.2	-0.5	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	0.3	1.2	-0.1	0.7
Mouth/teeth dental problems: Dentures	1.5	2.5	7.8	-0.9	1.1	-0.4	2.8
Asthma	0.7	1.5	2.7	-0.2	-1.1	-1.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.4	0.5	-0.7	-0.7	0.5
Medication: Cholesterol lowering	0.3	0.5	0.8	0.7	-0.9	-0.6	0.1
Depression (self-reported)	2.5	3.0	6.8	1.7	0.4	-1.4	-2.6
Medication: Lansoprazole	2.2	2.5	5.2	-0.6	-2.3	-2.1	0.3
Prospective memory result	1.6	1.9	5.2	-0.2	-0.5	-2.3	1.5
Lung cancer (father)	1.6	1.9	2.7	-1.6	0.9	-1.5	1.4
Illnesses of mother	1.7	2.1	7.3	-0.6	-2.7	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	1.1	-0.3	0.7	-1.0
Pulse wave Arterial Stiffness index	1.4	1.6	4.8	0.9	-2.2	0.4	-0.8
Impedance of arm (left)	1.0	4.6	16.4	-4.0	-1.0	-0.1	-1.0
Arm fat mass (right)	0.3	1.4	2.8	1.7	-1.4	0.7	-0.5
Trunk predicted mass	0.5	2.9	10.0	3.2	-0.3	1.2	0.0
Standing height	0.0	0.2	0.6	-0.2	0.1	0.4	-0.7
Length of working week for main job	0.7	0.8	2.0	-0.8	-0.6	1.4	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.2	-0.1	-0.6	-0.2
Breastfed as a baby	0.5	0.6	1.4	0.7	-0.6	0.4	1.2
Tense / ‘highly strung’	0.1	0.2	0.3	-0.5	-0.2	-0.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.1	1.1	-0.6	0.5
Hair/balding pattern: Pattern 4	1.7	4.0	13.9	3.7	0.6	1.3	0.1
Birth weight of first child	2.4	4.3	8.6	-2.9	1.7	0.4	2.4
Peak expiratory flow (PEF)	1.0	2.2	3.6	1.6	-0.8	1.9	-1.4
Pulse wave reflection index	0.5	0.7	1.4	-1.2	-1.1	0.2	-0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	-1.0	1.0	0.3	0.1
Loud music exposure frequency	3.2	3.5	8.4	-2.9	0.6	0.8	2.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	-0.2	1.3	-0.8	0.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	4.2	0.5	-0.2	0.3	2.0
Blood clot in the leg (DVT)	1.4	1.8	4.0	1.1	-1.3	-0.8	2.0
Medication: Paracetamol	0.5	0.8	2.2	-1.0	-0.0	-1.5	-0.2
Headache pain in last month	0.4	0.7	2.0	-1.4	-0.6	-0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	0.1	0.2	0.3	-1.0
Glaucoma (self-reported)	0.3	0.3	0.9	0.2	-0.3	-0.4	-1.0
Gout (self-reported)	1.4	2.0	5.2	1.6	-0.2	-2.3	-0.0
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	4.4	2.1	1.7	-1.9	-1.9
Medication: Amlodipine	0.5	0.7	1.2	-0.8	-0.9	1.1	-0.3
Medication: Ventolin 100micrograms inhaler	1.1	1.5	3.0	-1.2	0.7	-1.0	1.7
Birth weight	0.6	1.2	2.6	-0.5	1.6	0.8	1.1
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.5	0.4	2.1	-1.3	1.2
High blood pressure (siblings)	0.7	1.0	2.6	-0.7	1.6	-0.9	0.7
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	0.5	-0.6	0.2	-0.2
Body fat percentage	0.1	0.3	0.9	-0.3	-1.0	0.2	-0.4
Leg fat percentage (right)	0.1	0.5	1.4	0.2	-1.2	0.7	0.2
Arm fat-free mass (right)	0.5	2.8	10.2	3.2	0.5	0.8	-0.5
Exposure to tobacco smoke outside home	0.7	0.9	2.9	0.9	1.7	0.0	-0.2
Comparative body size at age 10	0.8	2.3	4.3	1.3	-1.5	0.8	-2.1
Number of full brothers	0.3	0.4	1.2	-1.1	-0.1	-0.1	0.6
Worry too long after embarrassment	0.3	0.5	1.4	-0.7	0.3	-0.3	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.2	0.5	-1.1	-0.5
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	-0.4	-0.2	-0.2	0.3
Number of children fathered	1.1	1.3	4.2	-0.1	-2.0	0.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	0.6	-0.7	0.5	-0.6
Age at first live birth	1.0	1.8	6.5	-0.4	-0.1	-0.8	-2.6
Pulse wave peak to peak time	1.2	1.5	4.5	-0.8	2.1	-0.4	0.7
Health satisfaction	1.1	1.5	2.9	1.2	-1.1	-1.7	0.4
Shortness of breath walking on level ground	0.1	0.2	0.3	-0.3	-0.2	-0.6	-0.5
Qualifications: College or University degree	0.8	2.4	5.7	2.4	-1.2	0.3	-1.5
Eye problems/disorders: None of the above	1.1	1.2	1.6	1.2	0.8	1.1	1.3
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.2	-1.1	-0.9	-0.9	-0.8
Emphysema/chronic bronchitis	1.2	1.3	4.5	-0.1	2.1	0.4	0.9
Medication for pain relief, constipation, heartburn	0.5	0.8	2.7	-0.1	0.5	1.6	-0.5
Neck or shoulder pain in last month	0.9	1.2	2.8	-0.4	0.0	-1.4	-1.7
Medication: Blood pressure	0.4	0.6	1.4	0.4	0.5	1.2	0.8
Angina (self-reported)	0.9	1.2	2.1	-1.0	1.3	-0.3	1.5
Migraine (self-reported)	0.3	0.4	0.6	-0.7	0.1	-0.8	0.7
Medication: Ibuprofen	0.9	1.0	1.4	1.2	-1.1	-1.0	0.8
Medication: Allopurinol	0.4	0.5	0.9	0.8	0.6	-0.9	0.5
Medication: Omeprazole	0.7	0.9	1.2	-1.0	-1.1	-0.6	1.1
Medication: Seretide 50 evohaler	1.6	1.8	6.2	0.6	0.0	-0.9	-2.5
Mean time to correctly identify matches	1.0	2.0	3.0	-0.7	1.6	-1.4	1.7
Heart disease (mother)	0.4	0.5	0.9	-0.3	1.0	-0.3	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	-1.4	0.1	-1.1	0.9
Whole body fat mass	0.2	0.7	1.2	1.1	-0.9	0.5	-0.7
Leg fat mass (right)	0.3	1.2	2.6	1.6	-1.2	0.6	-0.5
Arm predicted mass (right)	0.5	2.6	9.9	3.1	0.4	0.5	-0.5
Pulse rate, automated reading	0.6	1.8	5.1	2.3	1.3	-0.4	0.5
Alcohol intake frequency.	1.3	3.0	6.1	-1.6	1.8	0.2	2.5
Comparative height size at age 10	0.2	0.9	3.0	-1.7	0.2	0.3	-0.5
Number of full sisters	2.2	2.7	8.5	-2.9	1.0	-0.6	-1.0
Suffer from ‘nerves’	1.9	3.0	6.1	0.2	-1.4	-2.5	-2.0
Overall health rating	0.7	1.4	3.4	0.2	1.9	-1.5	0.4
Chest pain or discomfort	0.7	0.9	1.8	0.7	0.6	-1.4	-1.1
Had major operations	0.3	0.4	0.7	-0.8	-0.4	0.2	0.8
Age at last live birth	2.7	3.9	9.7	-0.5	-1.0	-2.2	-3.1
Family relationship satisfaction	0.3	0.4	1.2	0.6	-0.1	-1.1	0.4
Leg pain on walking	0.5	0.7	1.3	-0.9	1.2	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.6	-1.3	0.2	-0.3	0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	0.0	-0.7	0.9	-0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	1.0	-1.3	1.0	-0.1
Medication: Aspirin	0.8	1.1	2.6	0.3	0.6	-1.6	1.2
Supplements: Vitamin C	0.5	0.6	1.7	0.6	-0.3	-0.2	-1.3
Knee pain experienced in last month	0.5	0.7	1.5	-0.5	1.0	-0.2	1.2
Hypertension (Self-reported)	0.1	0.4	0.8	0.6	0.1	-0.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.5	0.6	-1.6	-0.1	-0.5
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.9	-0.3	0.1	0.7
Illnesses of siblings: Diabetes	0.5	0.6	2.2	0.2	1.5	0.1	0.2
Smoking status: Previous	1.6	2.5	7.8	-0.8	-2.8	-0.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.6	0.0	-0.1	-1.3	-0.2
Whole body fat-free mass	0.5	3.1	11.0	3.3	-0.5	0.9	-0.5
Leg fat-free mass (right)	0.5	2.6	8.9	3.0	-0.4	0.4	-1.0
Arm fat percentage (left)	0.3	1.1	2.5	0.7	-1.6	0.9	-0.8
Average weekly red wine intake	0.9	1.3	2.3	0.9	-1.5	-0.7	-1.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.8	-0.3	0.5	-0.0
Mood swings	0.7	1.3	2.4	1.3	1.5	1.1	-0.4
Loneliness, isolation	0.9	1.2	2.7	1.3	0.3	-1.6	0.5
Long-standing illness, disability or infirmity	0.9	1.3	2.1	1.4	0.8	-1.3	-1.0
Ever had bowel cancer screening	0.1	0.1	0.2	0.5	-0.0	-0.3	-0.0
Diabetes diagnosed by doctor	0.3	0.5	0.9	0.9	-0.3	-0.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.6	1.1	-2.2	0.2	-0.5
Friendships satisfaction	0.8	0.9	2.7	-0.2	0.9	-1.7	-0.4
Qualifications: nursing, teaching	1.1	1.8	6.7	2.6	0.1	0.5	0.4
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.7	0.2	0.2	-0.0
Eye problems/disorders: Cataract	0.6	0.6	1.8	0.7	0.5	1.3	0.1
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	5.0	2.2	-1.0	0.6	-0.7
Medication for cholesterol	0.5	0.7	2.2	-0.3	-0.6	1.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.6	1.6	-0.7	0.5	0.4
Back pain experienced in last month	0.3	0.5	0.9	-0.5	0.9	-0.6	-0.7
Mineral and other dietary supplements	0.7	1.0	2.3	-1.0	0.8	-1.5	0.1
Breast cancer (self-reported)	0.2	0.3	0.6	0.3	-0.4	0.8	-0.4
Asthma (self-reported)	0.6	1.2	2.8	-0.4	-1.0	-1.0	-1.7
Osteoporosis (self-reported)	0.8	1.0	2.3	0.1	-1.5	-0.2	-1.2
Osteoarthritis (self-reported)	1.0	1.3	3.1	0.6	-1.8	-0.9	0.8
Medication: Aspirin	1.0	1.3	4.3	0.8	0.1	-2.1	0.6
Medication: Gliclazide	0.1	0.2	0.3	0.4	0.1	-0.4	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	-0.4	0.0	1.4	-0.2
Smoking status: Current	0.2	0.4	1.2	1.1	0.0	-0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	0.0	0.7	1.2	0.1
Whole body water mass	0.6	3.1	11.3	3.4	-0.4	0.9	-0.5
Leg predicted mass (right)	0.5	2.5	8.9	3.0	-0.5	0.5	-0.9
Arm fat mass (left)	0.4	1.5	2.8	1.7	-1.4	0.8	-0.8
Number of self-reported non-cancer illnesses	2.5	4.3	12.1	2.0	-0.1	-3.5	-1.0
Average weekly champagne plus white wine intake	0.5	0.7	2.0	-0.1	1.4	-0.4	0.9
Miserableness	0.8	1.4	3.8	2.0	0.4	0.6	-1.1
Guilty feelings	0.4	0.5	1.1	0.4	-0.5	-1.1	-0.8
Wears glasses or contact lenses	1.3	1.5	3.9	-0.9	-2.0	-1.1	-0.6
Ever taken oral contraceptive pill	1.3	1.4	2.9	1.7	-0.0	-0.8	1.5
Hearing aid user	0.6	0.7	1.3	1.2	-0.9	-0.6	-0.4
Mother’s age at death	0.2	0.3	0.5	-0.3	-0.4	0.5	-0.7
Financial situation satisfaction	0.3	0.3	0.6	-0.2	-0.8	-0.8	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	0.8	0.8	0.7	0.2
Commuting to job workplace: Public transport	1.1	1.3	3.1	1.2	1.8	0.6	-0.6
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	0.4	-0.3	0.3	-1.4
Medication: Blood pressure	0.4	0.8	2.7	-0.5	0.3	-1.6	0.2
Pain type(s) experienced in last month: Hip pain	1.9	2.3	4.2	-1.0	1.9	-2.1	0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	1.4	-0.3	1.4	0.5
High cholesterol (Self-reported)	0.9	1.6	5.2	0.6	-0.5	-2.3	-0.6
Medication: Bendroflumethiazide	0.3	0.5	0.7	-0.7	-0.8	-0.8	0.4
Medication: Paracetamol	0.6	0.9	1.5	-1.2	-0.4	-1.1	0.8
Medication: Lisinopril	1.0	1.3	3.1	-0.5	-1.8	0.6	1.2
Medication: Atorvastatin	1.4	1.7	2.8	-1.3	-1.5	-1.7	0.2
Illnesses of father: High blood pressure	2.5	3.1	10.3	3.2	0.4	0.3	1.3
Alcohol drinker status: Never	1.1	1.3	2.1	1.0	1.5	0.3	1.4
Ever smoked	1.1	1.9	7.1	0.5	-2.7	-0.3	0.2
Basal metabolic rate	0.5	2.8	9.5	3.1	-0.6	0.9	-0.6
Leg fat percentage (left)	0.0	0.1	0.3	-0.2	-0.6	0.1	0.3
Arm fat-free mass (left)	0.4	2.0	7.7	2.8	0.2	0.3	-0.4
Number of operations (self-reported)	0.2	0.3	0.8	0.5	-0.2	-0.0	0.9
Average weekly beer plus cider intake	0.5	0.7	1.9	-1.4	-0.1	-0.6	0.6
Irritability	1.7	2.8	8.0	2.8	0.5	0.8	-1.5
Risk taking	0.9	1.4	4.9	2.2	0.2	-0.3	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.5	-0.5	-0.7	-0.2	-1.6
Fractured/broken bones in last 5 years	0.4	0.5	1.8	-1.4	-0.4	0.3	0.0
Age started oral contraceptive pill	1.1	1.4	3.9	0.6	2.0	-1.2	0.1
Diastolic blood pressure, automated reading	0.8	2.3	5.9	2.4	-1.4	-1.2	-0.4
Ever depressed for a whole week	3.0	3.7	12.5	0.1	3.5	1.0	1.1
Unable to work because of sickness or disability	1.0	1.4	4.4	2.1	-0.6	-0.1	-0.8
Commuting to job workplace: Cycle	0.8	1.0	2.1	1.5	-0.8	0.3	1.0
Myopia	1.6	2.3	6.8	0.3	-1.3	-0.7	-2.6
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.5	-0.9	-0.6	1.2	0.4
Cholesterol lowering medication	1.6	2.3	5.3	1.0	1.7	-2.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.5	-0.3	-1.6	-1.9	0.7
Pain experienced in last month	1.2	2.0	4.4	0.7	-2.1	1.5	-0.8
Supplements: Calcium	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.7
Basal cell carcinoma (self-reported)	1.8	2.1	7.8	-0.5	-0.3	-2.8	-0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	0.4	0.9	0.5	1.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	2.8	1.7	-1.0	-0.8	1.6
Heart disease (siblings)	0.8	0.9	1.9	1.2	-0.4	-1.4	-0.4
Alcohol drinker status: Previous	0.8	0.9	2.6	0.1	0.1	1.0	1.6
Pack years of smoking	0.6	0.8	1.8	1.0	1.3	0.6	0.4
Impedance of whole body	1.3	6.4	24.9	-5.0	0.1	-0.8	-0.4
Leg fat mass (left)	0.2	0.8	2.0	1.4	-0.8	0.3	-0.4
Arm predicted mass (left)	0.4	2.2	8.5	2.9	0.1	0.6	-0.3