TWAS hub - TSHZ3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.1560	0.0510	8.8e-05	0.139	NA	0.139	NA	0.135	8.5e-11	NA	9.0e-11	NA	1.7e-10
2	NTR	Blood	0.0502	0.0145	2.1e-07	0.004	0.026	0.016	0.026	0.009	1.8e-02	6.1e-09	3.4e-06	6.6e-09	3.9e-04
3	YFS	Blood	0.1882	0.0316	0.0e+00	0.024	0.116	0.130	0.125	0.125	1.7e-08	7.5e-36	2.5e-40	9.7e-39	8.8e-39

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FEV1/FVC ratio	7.8	39.7	74.8	-2.0	-6.4	-8.7
Birth weight	4.7	10.2	19.6	-0.5	4.4	3.3
Guilty feelings	4.6	6.9	14.0	-0.9	3.7	2.4
Body Mass Index (BMI) (2010)	4.1	5.7	10.1	1.6	-3.2	-2.1
Type 2 Diabetes (T2D) (2018)	4.0	7.5	8.7	-2.3	3.0	3.0
Falls in the last year	4.0	5.4	7.5	-2.7	2.1	2.1
Ever used hormone-replacement therapy (HRT)	3.9	4.9	6.7	-2.6	2.2	1.8
Systolic Blood Pressure	3.8	18.8	25.6	2.4	-5.1	-5.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.8	4.5	8.4	-2.9	1.0	2.1
Neck or shoulder pain in last month	3.7	5.3	12.2	-0.1	3.5	1.9
Stomach or abdominal pain in last month	3.5	4.3	5.4	1.7	2.2	2.3
Medication: Bendroflumethiazide	3.5	5.4	7.8	1.4	-2.5	-2.8
Number of operations (self-reported)	3.5	5.1	8.7	-0.3	2.6	3.0
Heart attack	3.4	4.4	5.9	-1.3	2.4	2.4
Heart attack/myocardial infarction (self-reported)	3.3	4.2	5.7	-1.3	2.4	2.3
Systolic blood pressure, automated reading	3.0	8.7	13.1	1.2	-3.4	-3.6
Medication: Metformin	3.0	4.2	5.5	-1.8	2.3	1.9
Emphysema/chronic bronchitis	3.0	3.4	6.2	2.5	-0.6	-1.9
Long-standing illness, disability or infirmity	3.0	4.6	11.9	0.6	3.5	1.2
Lung cancer (father)	2.9	3.4	6.8	-1.2	1.4	2.6
Ever depressed for a whole week	2.9	3.6	5.9	-2.4	1.6	1.4
Hair/balding pattern: Pattern 2	2.8	3.6	5.1	0.9	-2.3	-2.2
Nervous feelings	2.7	4.9	7.5	1.7	-2.7	-2.1
Father’s age at death	2.7	3.6	8.7	-2.9	-1.4	-0.3
Worry (Nagel 2018)	2.6	5.4	6.7	2.0	-2.4	-2.6
Number of live births	2.5	3.5	8.7	-0.8	1.1	3.0
High blood pressure (siblings)	2.5	3.6	8.3	0.0	-1.6	-2.9
Ever had hysterectomy (womb removed)	2.4	2.7	3.0	-1.7	1.5	1.6
Angina	2.4	3.2	4.6	-1.9	2.1	1.1
Ever had prostate specific antigen (PSA) test	2.4	2.8	5.9	-2.4	-1.4	-0.7
Neuroticism (2016)	2.3	3.3	6.8	1.0	-1.4	-2.6
Chronotype (morning person)	2.3	5.4	5.9	-2.3	2.2	2.4
Risk taking	2.3	3.4	5.1	0.0	2.2	2.3
Medication for pain relief, constipation, heartburn	2.2	3.8	8.4	-2.9	-1.7	-0.4
Diabetes diagnosed by doctor	2.2	3.6	3.9	-1.9	2.0	1.8
Diastolic blood pressure, automated reading	2.2	6.7	8.3	2.3	-2.9	-2.6
Pulse wave reflection index	2.1	2.6	4.1	1.0	-2.0	-1.7
Had major operations	2.1	2.5	3.7	-0.8	1.8	1.9
Knee pain experienced in last month	2.1	3.2	5.8	-1.5	2.4	1.3
Illnesses of father: High blood pressure	2.1	2.6	6.1	0.2	2.5	1.3
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.1	-0.3	2.0	1.7
Medication: Lisinopril	2.0	2.6	6.2	0.3	-2.5	-1.2
Current tobacco smoking	1.9	3.2	6.0	2.5	1.7	0.8
Suffer from ‘nerves’	1.9	3.0	4.5	1.2	-2.1	-1.8
Alzheimer’s Disease (in mother)	1.8	2.1	3.5	-1.1	-1.9	-1.3
Alzheimer’s Disease (including proxy)	1.8	2.6	5.3	-1.1	-2.3	-1.1
Major Depression (MDD)	1.8	2.2	3.5	0.1	1.7	1.9
Reaction Time	1.8	3.4	7.3	0.7	-2.7	-1.6
Verbal and Numeric Reasoning (VNR)	1.8	4.3	5.5	-1.7	2.2	2.3
Diabetes (self-reported)	1.8	2.8	3.1	-1.8	1.6	1.6
Time employed in main current job	1.8	2.1	5.7	2.4	0.4	-0.7
Angina (self-reported)	1.8	2.4	3.3	-1.7	1.8	1.0
Ever had bowel cancer screening	1.8	2.1	4.4	-0.8	2.1	1.1
Osteoarthritis (self-reported)	1.8	2.3	3.3	-1.5	1.8	1.1
Coronary Artery Disease (CAD)	1.7	2.0	3.3	1.8	-1.1	-1.2
Birth weight of first child	1.7	3.2	5.6	-0.8	2.4	1.8
Exposure to tobacco smoke outside home	1.7	2.3	4.1	0.7	-1.5	-2.0
Age at first live birth	1.7	3.0	5.3	0.6	-2.3	-1.8
Health satisfaction	1.7	2.2	3.3	1.8	1.7	0.4
Smoking status: Current	1.7	2.8	6.4	2.5	1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	6.9	-1.6	-1.2	-2.6
Alzheimer’s Disease (in father)	1.6	1.7	3.6	-0.5	-1.9	-1.2
High blood pressure	1.6	4.5	6.9	0.7	-2.4	-2.6
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	2.8	-0.4	1.7	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	5.4	-0.4	2.3	1.4
Number of children fathered	1.6	1.8	3.4	-0.7	1.2	1.8
Medication: Seretide 50 evohaler	1.6	1.8	2.7	0.0	1.6	1.6
Type 2 Diabetes (T2D) (2012)	1.5	1.8	2.4	-1.3	1.2	1.6
Medication: Atenolol	1.5	1.9	4.0	0.2	-1.3	-2.0
Had menopause	1.5	1.9	4.0	-2.0	0.8	1.1
Loud music exposure frequency	1.5	1.7	3.9	2.0	-0.1	-1.1
Mean time to correctly identify matches	1.5	2.9	5.9	0.1	-2.4	-1.7
Irritable Bowel Disease (IBD)	1.4	3.2	6.6	0.9	-1.5	-2.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	4.6	-0.8	-0.6	-2.1
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.9	-0.4	2.2	0.3
Tinnitus: Yes, now most or all of the time	1.4	1.7	4.0	1.0	2.0	0.3
Unable to work because of sickness or disability	1.4	1.8	3.1	1.8	1.0	1.2
Intelligence (Savage-Jansen 2018)	1.3	3.9	6.9	-2.6	1.1	1.9
Schizophrenia (2018)	1.3	2.8	3.9	0.8	1.9	2.0
Ulcerative Colitis (UC)	1.3	2.4	4.9	0.8	-1.3	-2.2
Prostate Cancer	1.3	1.9	5.5	-0.1	0.3	2.3
Neuroticism	1.3	3.1	5.8	2.4	-1.1	-1.6
Pain all over the body in last month	1.3	1.4	4.0	-0.6	-0.1	-2.0
Comparative body size at age 10	1.3	3.6	6.3	2.5	1.9	0.9
Overall health rating	1.3	2.7	5.5	2.4	1.6	-0.1
Age at last live birth	1.3	1.9	4.3	1.0	-2.1	-0.6
Vascular/heart problems diagnosed by doctor	1.3	3.6	6.1	-0.6	2.1	2.5
Heart disease (siblings)	1.3	1.6	4.3	-2.1	0.8	0.0
Fasting Glucose	1.2	1.5	2.6	-0.5	-1.6	-1.3
Depression (self-reported)	1.2	1.4	2.5	-0.1	1.3	1.6
Medication: Aspirin	1.2	1.6	4.5	0.4	2.1	0.4
Lupus	1.1	1.7	3.5	-1.0	-1.9	-0.8
Schizophrenia (2014)	1.1	2.3	3.5	0.3	1.9	1.8
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.5	1.9	-0.3	-1.1
Fluid intelligence score	1.1	2.2	3.6	-1.3	1.2	1.9
Illnesses of siblings	1.1	1.5	3.0	0.6	1.1	1.7
Mouth/teeth dental problems: Dentures	1.1	1.9	4.3	-0.3	2.1	1.2
Tense / ‘highly strung’	1.1	1.8	4.8	2.2	0.8	-0.3
Alcohol intake frequency.	1.1	2.5	5.7	1.1	2.4	0.7
Hypertension (Self-reported)	1.1	3.0	5.0	0.7	-1.9	-2.2
Loneliness, isolation	1.1	1.5	3.6	1.9	-0.4	-0.8
Medication: Aspirin	1.1	1.4	4.0	0.5	2.0	0.1
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.1	-0.0	1.8	1.1
Age started oral contraceptive pill	1.1	1.4	1.7	-1.1	1.3	1.1
Breast Cancer	1.0	2.3	4.7	-2.2	-0.4	1.4
Pack years adult smoking proportion	1.0	1.5	3.4	1.8	-0.7	-0.7
Chronic bronchitis/emphysema (father)	1.0	1.2	2.1	0.7	-1.0	-1.4
Breastfed as a baby	1.0	1.2	2.5	-0.2	1.6	1.1
Medication: Omeprazole	1.0	1.2	1.6	1.3	1.2	0.6
Medication: Blood pressure	1.0	1.9	3.8	1.3	-0.4	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.6	1.6	1.0	0.3
Supplements: Calcium	1.0	1.1	3.1	1.8	0.2	-0.1
Cardiovascular Disease	0.9	3.0	3.5	1.9	-1.7	-1.7
Hand grip strength (right)	0.9	2.5	5.0	2.2	1.5	0.2
Hair/balding pattern: Pattern 3	0.9	1.3	3.4	-1.9	-0.6	-0.5
Medication: Paracetamol	0.9	1.4	3.4	1.8	0.7	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.4	-0.9	0.3	-1.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.7	0.5	-0.6	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.9	1.7	0.3	0.5
Average weekly red wine intake	0.9	1.3	3.0	-0.9	-0.0	1.7
Mood swings	0.9	1.6	2.8	1.7	1.0	1.0
Friendships satisfaction	0.9	1.1	2.9	-0.5	-1.7	-0.5
Average weekly champagne plus white wine intake	0.9	1.2	2.5	1.6	-0.8	-0.7
Commuting to job workplace: Public transport	0.9	1.1	2.3	-0.7	-0.7	-1.5
Bipolar Disorder or Schizophrenia	0.8	1.9	3.1	1.1	1.2	1.7
Ovarian Cancer	0.8	1.0	1.6	-0.7	1.3	1.0
Crohns Disease (2012)	0.8	1.3	3.5	0.4	-0.4	-1.9
Qualifications: CSEs or equivalent	0.8	1.0	2.1	0.5	-0.8	-1.5
Supplements: Glucosamine	0.8	1.0	3.1	0.1	1.7	0.1
High blood pressure (mother)	0.8	1.2	2.9	0.2	-0.8	-1.7
Had other major operations	0.8	1.0	1.7	-0.5	1.3	1.0
Medication: Ramipril	0.8	1.0	2.9	0.3	1.7	-0.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.9	-1.0	-1.4	-2.2
Length of working week for main job	0.8	0.9	1.2	0.8	0.9	-1.1
Headache pain in last month	0.8	1.4	2.4	1.6	0.4	-1.2
Illnesses of siblings: Diabetes	0.8	0.9	1.7	-0.5	0.9	1.3
Smoking status: Previous	0.8	1.3	3.4	-1.8	-0.5	0.4
Qualifications: nursing, teaching	0.8	1.2	3.2	-0.5	0.3	1.8
Pack years of smoking	0.8	1.1	2.2	1.5	-0.7	-0.8
Crohns Disease (2017)	0.7	1.6	3.0	0.7	-1.1	-1.7
Townsend deprivation index at recruitment	0.7	1.0	2.4	0.4	-0.7	-1.6
Serious illness, injury or assault to yourself	0.7	0.9	2.6	0.1	1.6	0.3
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.3	0.3	1.4	1.5
Number of incorrect matches in round	0.7	1.2	2.0	1.2	1.4	-0.3
Financial difficulties in last 2 years	0.7	1.0	2.6	-0.6	1.6	0.1
Gout (self-reported)	0.7	1.0	1.9	1.0	-0.3	-1.4
Worry too long after embarrassment	0.7	1.1	2.4	-0.5	-1.6	-0.8
Medication: Allopurinol	0.7	0.9	2.0	1.4	0.7	-0.4
Heart disease (mother)	0.7	0.8	1.3	-1.2	1.0	-0.2
Leg pain on walking	0.7	0.8	1.4	-0.6	1.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.6	-1.9	0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.0	-1.0	0.9	0.6
Commuting to job workplace: Walk	0.7	0.8	1.5	0.3	-0.9	-1.2
Osteoporosis (self-reported)	0.7	0.8	2.5	1.6	-0.0	-0.1
Ever taken oral contraceptive pill	0.7	0.7	1.0	-1.0	0.5	1.0
Medication: Atorvastatin	0.7	0.8	1.8	-0.2	0.8	1.4
Depressed Affect (Nagel 2018)	0.6	1.3	3.6	1.9	0.2	0.5
Neuroticism (Nagel 2018)	0.6	1.4	3.7	1.9	-0.3	-0.6
Ulcerative Colitis	0.6	0.9	1.5	0.3	-1.1	-1.2
Smoking Status	0.6	1.4	1.8	1.3	0.9	1.3
Average weekly spirits intake	0.6	0.8	2.2	-1.5	-0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	-0.1	1.5	-0.3
Severe depression (siblings)	0.6	0.7	1.3	0.8	1.1	0.5
Relative age voice broke	0.6	1.0	2.7	-0.3	-1.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	-0.8	-0.3	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	0.7	1.4	0.7
Mouth/teeth dental problems	0.6	1.0	1.7	1.3	-0.4	1.0
Neuroticism score	0.6	1.3	2.8	1.7	-0.8	-0.8
Asthma	0.6	1.1	2.6	-1.6	0.8	0.5
Medication: Lansoprazole	0.6	0.7	1.2	0.1	1.1	1.0
Illnesses of mother	0.6	0.7	1.3	1.1	0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.9	-0.8	-0.5	-2.2
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.5	0.1	1.0	1.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.0	1.0	1.4	0.4
Pulse rate, automated reading	0.6	2.0	4.9	2.2	-0.9	-0.4
Family relationship satisfaction	0.6	0.8	1.7	-1.3	-0.8	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.7	-1.6	0.5	0.1
Medication for cholesterol	0.6	1.0	1.6	-1.3	0.0	1.1
Breast cancer (self-reported)	0.6	0.7	1.8	-1.3	-0.5	0.3
Fractured/broken bones in last 5 years	0.6	0.8	1.7	0.6	1.3	0.7
Mean Putamen Volume	0.5	0.6	1.0	0.7	1.0	0.5
HDL Cholesterol	0.5	0.8	1.7	-1.3	-0.1	-0.9
Rheumatoid Arthritis	0.5	0.6	1.6	-1.3	0.4	-0.4
Hypothyroidism (self reported)	0.5	1.1	2.1	1.4	0.7	-0.9
Sensitivity / hurt feelings	0.5	0.8	1.3	0.8	-1.1	-0.7
Pulse rate	0.5	0.8	1.4	1.2	-0.8	-0.7
Noisy workplace	0.5	0.6	1.5	0.5	0.3	-1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	-0.9	-1.2	0.4
Medication: Blood pressure	0.5	1.0	1.6	-0.2	-1.1	-1.3
Number of full sisters	0.5	0.6	1.0	0.6	0.6	1.0
Eye problems/disorders: Cataract	0.5	0.5	0.8	-0.6	0.6	0.9
Mineral and other dietary supplements	0.5	0.7	1.7	-0.2	-1.3	-0.5
Medication: Gliclazide	0.5	0.5	1.5	0.1	1.2	-0.2
Financial situation satisfaction	0.5	0.6	1.6	-0.3	1.3	0.3
High cholesterol (Self-reported)	0.5	0.9	1.7	0.8	0.7	1.3
Ever smoked	0.5	1.0	1.7	-0.2	1.1	1.3
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.1	1.2	0.7
Alcohol drinker status: Previous	0.5	0.6	1.6	1.3	0.4	0.2
Age at First Birth	0.4	0.6	1.1	1.1	-0.8	-0.4
Respiratory disease	0.4	0.8	2.3	-0.3	1.5	-0.3
Fed-up feelings	0.4	0.7	1.4	1.2	-0.6	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.7	-0.3	0.8	0.8
Taking other prescription medications	0.4	0.7	1.4	0.7	1.2	-0.2
Waist circumference	0.4	1.3	2.4	1.2	-0.3	-1.6
Allergy	0.4	0.9	1.9	0.1	-1.4	-0.8
Worrier / anxious feelings	0.4	0.7	1.2	1.1	-0.2	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.1	-1.4	-0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.1	0.9	0.9
Medication: Amlodipine	0.4	0.6	1.6	0.3	-1.3	-0.4
Medication: Ibuprofen	0.4	0.5	1.1	1.1	-0.3	-0.6
Chest pain or discomfort	0.4	0.5	1.4	-0.2	1.2	0.4
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.9	0.7	0.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	-0.1	1.0	0.6
Asthma (self-reported)	0.4	0.9	2.3	-1.5	0.5	0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.3	0.8	1.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.4	0.7	-0.8	0.8	-0.1
Myopia	0.4	0.5	1.1	0.6	-1.0	-0.5
Pain experienced in last month	0.4	0.7	1.0	-1.0	-0.6	0.8
Bipolar Disorder (2011)	0.3	0.3	0.7	0.3	-0.8	-0.2
HbA1C	0.3	0.4	1.0	0.2	1.0	0.4
Blood Red Count	0.3	3.1	4.7	2.2	-1.9	-1.0
Hand grip strength (left)	0.3	0.8	1.8	1.3	0.7	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-0.1	0.5	1.1
Vitamin and mineral supplements	0.3	0.4	0.6	0.5	-0.4	-0.8
Age when periods started (menarche)	0.3	0.8	1.3	0.9	-1.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.4	-0.9	-0.2
Medication: Levothyroxine sodium	0.3	0.5	1.4	-0.1	1.2	-0.4
Past tobacco smoking	0.3	0.5	0.9	0.9	-0.1	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.7	-1.0	0.1
Qualifications: None of the above	0.3	0.6	1.3	-0.1	0.7	-1.1
Hip circumference	0.3	1.1	2.3	1.0	-0.0	-1.5
Happiness	0.3	0.4	1.1	1.1	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	-0.5	0.8	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	1.0	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	-0.9	-0.3	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	0.7	0.7	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-0.5	0.5	1.0
Glaucoma (self-reported)	0.3	0.4	0.5	-0.6	0.5	0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	0.9	0.9	-0.4
Shortness of breath walking on level ground	0.3	0.3	0.4	0.6	0.5	-0.6
Supplements: Vitamin C	0.3	0.3	0.9	-0.0	0.0	-1.0
Illnesses of father: Heart disease	0.3	0.5	1.3	0.3	1.1	0.1
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.5	-0.2	-0.9
Medication: Paracetamol	0.3	0.4	0.7	0.8	0.1	-0.8
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.8	0.3	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.8	0.1	0.7
Bipolar Disorder (2018)	0.2	0.4	0.8	0.9	-0.5	0.3
Depression (Nagel 2018)	0.2	0.2	0.5	0.2	0.7	0.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	-0.3	0.6	-0.4
LDL Cholesterol	0.2	0.3	0.7	0.4	-0.4	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.3	-0.8	-0.5
Blood Eosinophil Count	0.2	1.5	2.8	0.3	1.3	1.7
Blood White Count	0.2	1.6	2.2	1.1	-1.1	-1.5
Waist Hip Ratio (WHR)	0.2	0.9	2.3	-0.4	-1.5	-0.6
Allergy or Eczema	0.2	0.4	0.7	-0.1	0.8	0.7
Lung FVC	0.2	1.0	2.0	-0.3	-1.0	-1.4
Number of treatments/medications taken	0.2	0.3	0.4	0.7	0.6	-0.5
Relative age of first facial hair	0.2	0.5	1.2	0.3	-1.1	-0.5
Medication for hormone replacement therapy	0.2	0.2	0.4	0.3	-0.5	0.6
Diabetes (father)	0.2	0.3	0.4	-0.4	0.5	-0.6
Leg fat-free mass (left)	0.2	0.8	1.9	0.6	1.4	-0.3
Trunk fat percentage	0.2	0.7	1.1	-0.0	1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.9	0.6	-0.4
Multivitamins +/- minerals	0.2	0.2	0.5	-0.3	0.2	0.7
Alcohol usually taken with meals	0.2	0.3	0.8	0.1	-0.9	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.7	0.5	-0.2
Arm fat mass (right)	0.2	0.8	1.6	0.9	1.3	-0.3
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.3	0.1	0.8
Peak expiratory flow (PEF)	0.2	0.5	1.0	-0.2	-0.8	-1.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.3	0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.9	-0.4	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.1	-0.6	0.7
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.4	0.7	-0.1
Leg fat mass (right)	0.2	0.7	1.0	0.6	1.0	-0.8
Comparative height size at age 10	0.2	0.8	2.4	-0.2	1.6	-0.1
Back pain experienced in last month	0.2	0.3	0.5	0.0	0.7	0.6
Arm fat mass (left)	0.2	0.9	2.1	0.8	1.4	-0.2
Wears glasses or contact lenses	0.2	0.3	0.5	-0.5	-0.7	-0.0
Mother’s age at death	0.2	0.2	0.4	0.3	-0.7	0.3
Alcohol drinker status: Never	0.2	0.2	0.5	0.2	0.7	0.3
Irritability	0.2	0.3	0.5	0.7	0.7	0.1
Leg fat mass (left)	0.2	0.6	0.7	0.6	0.8	-0.9
Triglycerides	0.1	0.2	0.4	0.6	-0.2	-0.6
Heel T-Score	0.1	0.5	0.7	-0.8	0.8	-0.2
BMI	0.1	0.5	0.8	0.9	-0.3	-0.8
Height	0.1	1.3	3.4	0.5	1.8	-0.4
Tanning	0.1	1.0	1.8	-0.7	0.8	1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.5	-0.1	0.1
Supplements: Zinc	0.1	0.1	0.3	0.4	-0.5	-0.1
Medication: Co-codamol	0.1	0.1	0.1	0.4	0.2	-0.1
Diabetes (mother)	0.1	0.1	0.1	0.2	0.3	0.4
Impedance of leg (right)	0.1	0.3	0.5	-0.7	-0.6	0.0
Average weekly fortified wine intake	0.1	0.1	0.3	0.5	-0.1	-0.2
Maternal smoking around birth	0.1	0.1	0.2	-0.3	-0.0	0.4
Sitting height	0.1	0.6	1.1	1.0	0.9	0.1
Body mass index (BMI)	0.1	0.6	0.8	0.6	0.9	-0.7
Impedance of leg (left)	0.1	0.4	0.8	-0.7	-0.9	-0.1
Leg predicted mass (left)	0.1	0.8	1.7	0.7	1.3	-0.3
Trunk fat mass	0.1	0.6	1.1	0.1	1.0	-0.9
Forced vital capacity (FVC)	0.1	0.2	0.5	-0.7	-0.1	-0.3
Weight	0.1	0.7	1.3	0.6	1.1	-0.7
Arm fat percentage (right)	0.1	0.5	0.5	0.7	0.7	-0.5
Medication: Cholesterol lowering	0.1	0.2	0.6	0.1	0.8	0.1
Prospective memory result	0.1	0.2	0.2	0.5	0.4	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	0.1	0.2
Impedance of arm (left)	0.1	0.4	0.9	-0.9	0.4	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.4	0.4	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.3	-0.4	0.5	-0.5
Body fat percentage	0.1	0.5	0.7	0.0	0.8	-0.8
Leg fat percentage (right)	0.1	0.5	0.9	0.4	0.6	-0.9
Arm fat-free mass (right)	0.1	0.5	1.0	0.6	1.0	-0.3
Number of full brothers	0.1	0.2	0.5	0.7	0.0	0.1
Pulse wave peak to peak time	0.1	0.1	0.3	-0.6	0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	-0.4	0.2
Migraine (self-reported)	0.1	0.1	0.2	0.2	-0.1	-0.4
Whole body fat mass	0.1	0.6	1.2	0.3	1.1	-0.6
Arm predicted mass (right)	0.1	0.7	1.7	0.7	1.3	-0.2
Whole body fat-free mass	0.1	0.4	0.7	0.6	0.8	-0.4
Leg fat-free mass (right)	0.1	0.6	1.2	0.7	1.1	-0.4
Arm fat percentage (left)	0.1	0.6	1.2	0.6	1.1	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.6	0.1	0.5
Whole body water mass	0.1	0.6	0.9	0.9	0.9	-0.3
Leg predicted mass (right)	0.1	0.6	1.1	0.8	1.1	-0.4
Miserableness	0.1	0.1	0.3	0.5	-0.1	0.2
Hearing aid user	0.1	0.1	0.2	0.1	-0.2	0.4
Basal metabolic rate	0.1	0.7	1.2	0.9	1.1	-0.4
Leg fat percentage (left)	0.1	0.4	1.0	0.1	0.4	-1.0
Arm fat-free mass (left)	0.1	0.6	1.0	1.0	0.9	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.2	0.2	-0.7
Impedance of whole body	0.1	0.3	0.7	-0.9	-0.2	0.4
Arm predicted mass (left)	0.1	0.7	1.2	1.0	1.1	0.0
Blood Platelet Count	0.0	0.3	0.8	0.9	-0.0	0.3
Hair Pigment	0.0	0.3	0.3	0.5	0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.3	0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.1	0.1	-0.1	-0.2	0.3
Medication: Simvastatin	0.0	0.1	0.2	0.1	0.4	-0.2
Impedance of arm (right)	0.0	0.1	0.2	-0.4	-0.2	0.4
Trunk fat-free mass	0.0	0.3	0.4	0.6	0.5	-0.3
Trunk predicted mass	0.0	0.3	0.4	0.7	0.6	-0.2
Standing height	0.0	0.2	0.3	-0.2	0.6	-0.3
Qualifications: College or University degree	0.0	0.1	0.3	0.4	-0.0	0.5
Cholesterol lowering medication	0.0	0.1	0.2	-0.0	0.4	-0.1

Hub : Genes

TSHZ3

Models

Trait associations