Hub : Genes

TSKU

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.4310 0.1130 1.7e-03 0.154 NA 0.079 NA 0.147 9.0e-05 NA 4.5e-03 NA 1.3e-04
2 GTEx Muscle Skeletal 0.2886 0.0603 2.9e-05 -0.003 NA -0.002 NA -0.003 8.8e-01 NA 7.4e-01 NA 8.6e-01
3 GTEx Skin Sun Exposed Lower leg 0.1570 0.0490 1.8e-03 0.042 NA 0.039 NA 0.032 2.2e-04 NA 3.2e-04 NA 1.1e-03
4 METSIM Adipose 0.0725 0.0260 4.1e-04 0.009 0.017 0.024 0.024 0.024 1.3e-02 1.1e-03 1.2e-04 1.5e-04 1.2e-04
5 ROSMAP Brain Pre-frontal Cortex 0.1198 0.0320 3.3e-06 0.047 0.055 0.067 0.065 0.072 9.3e-07 1.1e-07 5.9e-09 1.0e-08 1.5e-09
6 TCGA Pancreatic Adenocarcinoma 0.0930 0.0450 4.4e-03 0.028 0.069 0.017 NA 0.028 2.4e-02 7.5e-04 6.0e-02 NA 2.5e-02
7 TCGA Thyroid Carcinoma 0.0560 0.0300 3.9e-03 0.031 0.014 0.007 NA 0.019 4.7e-04 1.6e-02 6.1e-02 NA 5.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.4 3.7 8.9 -2.3 0.0 -1.6 3.0 1.5 -1.9 1.9
Bipolar Disorder or Schizophrenia 1.4 3.4 5.5 -2.2 0.0 -1.9 2.3 0.4 -2.3 2.1
Depressed Affect (Nagel 2018) 0.1 0.2 0.9 0.4 0.0 -0.2 0.1 -0.2 -0.9 0.1
Depression (Nagel 2018) 0.2 0.3 1.0 0.4 0.0 -1.0 0.2 -0.2 -0.7 0.1
Intelligence (Savage-Jansen 2018) 2.3 7.1 12.1 -3.4 0.0 -3.3 1.9 0.2 -3.5 3.3
Neuroticism (Nagel 2018) 0.5 1.1 4.2 -0.3 0.0 -0.9 1.3 -0.2 -2.0 1.1
Schizophrenia (2018) 0.4 0.9 2.2 -1.0 0.0 -1.0 0.6 -0.7 -1.5 1.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 -0.5 0.0 -0.8 -0.6 -0.4 -0.7 0.6
Worry (Nagel 2018) 0.1 0.3 0.9 0.9 0.0 -0.2 0.4 0.1 -0.9 -0.1
Alzheimer’s Disease (in mother) 0.8 0.9 2.5 1.2 0.0 -0.5 -0.5 -1.6 1.0 -1.0
Alzheimer’s Disease (in father) 0.8 0.9 1.8 -0.7 0.0 -1.0 1.2 0.8 -1.3 0.9
Alzheimer’s Disease (including proxy) 0.6 0.8 2.3 1.5 0.0 0.3 -0.2 -0.6 1.0 -1.4
Crohns Disease (2017) 0.2 0.4 1.7 -0.1 0.0 -0.7 -0.4 -1.3 -0.7 0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 -0.6 0.0 0.2 0.2 0.2 -0.5 0.8
Ulcerative Colitis (UC) 0.3 0.6 1.3 -0.9 0.0 0.5 1.0 1.1 -0.1 0.8
Major Depression (MDD) 3.2 3.8 8.5 2.9 0.0 2.1 -2.0 -0.3 1.5 -2.8
Reaction Time 1.4 2.7 7.0 1.9 0.0 -0.5 -2.4 -2.6 -0.5 -1.4
Verbal and Numeric Reasoning (VNR) 1.6 4.0 9.4 -2.3 0.0 -3.1 1.6 0.7 -2.4 2.2
Breast Cancer 0.6 1.4 3.2 1.8 0.0 -0.4 -1.1 -1.8 0.6 -1.4
Ovarian Cancer 0.8 1.1 2.7 0.8 0.0 1.6 -1.3 1.0 0.7 -1.1
Prostate Cancer 1.1 1.5 3.0 -1.4 0.0 -1.5 0.6 0.5 -1.7 1.6
Age at First Birth 2.2 3.3 6.9 -2.2 0.0 -0.4 2.0 2.6 -1.6 2.1
Bipolar Disorder (2011) 1.4 1.4 5.2 -1.0 0.0 -0.7 2.3 0.7 -1.1 1.1
Body Mass Index (BMI) (2010) 0.1 0.2 0.5 0.5 0.0 -0.7 -0.6 0.1 -0.1 -0.3
Coronary Artery Disease (CAD) 0.7 0.9 3.7 0.5 0.0 -1.2 -1.9 -0.8 0.1 -0.2
Crohns Disease (2012) 0.3 0.5 1.9 0.4 0.0 -0.3 -1.4 -0.0 0.7 -0.8
Mean Putamen Volume 0.5 0.6 2.3 -0.3 0.0 1.2 0.5 0.1 1.5 -0.2
Fasting Glucose 1.3 1.5 3.5 0.5 0.0 1.2 -1.6 0.7 1.9 -1.6
HbA1C 0.7 0.8 2.4 -1.2 0.0 0.8 0.0 1.5 -0.5 0.8
HDL Cholesterol 2.1 3.5 7.7 -2.8 0.0 -0.4 2.2 1.1 -1.9 2.6
LDL Cholesterol 0.2 0.3 0.8 0.5 0.0 0.3 -0.7 -0.9 -0.3 -0.4
Lupus 0.2 0.4 1.4 -0.5 0.0 0.4 -0.6 0.1 1.2 -0.6
Neuroticism (2016) 0.7 1.1 4.4 1.3 0.0 0.4 0.8 -2.1 0.4 -0.7
Primary Biliary Cirrhosis 0.1 0.2 1.4 0.1 0.0 0.1 0.1 1.2 0.0 0.1
Rheumatoid Arthritis 2.3 3.1 6.7 2.4 0.0 0.9 -1.2 -1.1 2.4 -2.6
Schizophrenia (2014) 1.0 2.3 5.5 -1.8 0.0 -1.6 1.3 -0.0 -2.4 1.8
Triglycerides 1.4 2.3 5.1 2.2 0.0 0.3 -2.2 -0.9 1.2 -2.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.7 -0.1 0.0 -0.8 0.8 -0.1 0.1 0.2
Ulcerative Colitis 0.5 0.8 2.5 -1.0 0.0 0.3 0.9 1.6 -0.4 0.9
Blood Eosinophil Count 0.3 2.0 12.8 -0.6 0.0 0.3 -3.6 -0.8 -0.2 -0.1
Blood Platelet Count 0.4 4.7 22.8 1.2 0.0 -1.2 -2.5 -4.8 -1.0 -0.6
Blood Red Count 0.2 1.8 4.5 -0.5 0.0 2.1 -0.3 2.0 2.0 -0.0
Blood White Count 0.4 2.7 12.7 0.9 0.0 1.3 -3.6 -0.2 1.6 -1.2
Heel T-Score 0.6 4.6 19.2 0.5 0.0 4.4 -0.8 1.4 2.8 -1.6
BMI 3.4 19.5 39.8 5.0 0.0 2.8 -4.7 -1.8 6.2 -6.3
Height 0.4 8.4 18.6 -4.3 0.0 -2.1 3.1 1.2 -2.6 4.2
Waist Hip Ratio (WHR) 0.1 0.5 1.4 0.8 0.0 1.1 1.2 0.3 -0.0 -0.6
Systolic Blood Pressure 1.0 5.1 15.1 3.9 0.0 1.0 -1.9 -1.4 1.6 -3.4
Smoking Status 0.9 2.2 5.3 2.3 0.0 1.0 -1.4 -1.6 1.1 -1.9
Allergy or Eczema 0.2 0.6 3.4 -0.2 0.0 0.8 -0.5 -1.8 0.0 0.1
Cardiovascular Disease 2.1 6.8 12.4 3.5 0.0 0.4 -3.4 -2.6 2.5 -3.3
Hypothyroidism (self reported) 2.9 6.7 15.9 3.0 0.0 0.9 -4.0 -2.7 2.4 -2.9
Respiratory disease 0.9 1.9 6.5 1.5 0.0 0.6 -2.6 -0.1 1.4 -1.5
Type 2 Diabetes (T2D) (2018) 3.4 6.3 11.5 3.1 0.0 2.4 -2.5 -0.7 3.2 -3.4
Lung FEV1/FVC ratio 0.6 3.0 11.8 1.9 0.0 1.0 -3.4 -0.8 0.9 -1.8
Lung FVC 0.1 0.7 2.5 -0.3 0.0 0.7 1.1 0.5 1.6 -0.4
Neuroticism 0.6 1.5 3.8 -0.5 0.0 -1.0 1.5 1.3 -1.9 1.1
Chronotype (morning person) 0.4 1.0 4.0 0.1 0.0 -1.5 -2.0 0.0 -0.8 0.1
Hair Pigment 0.0 1.2 6.6 0.1 0.0 2.6 -1.1 0.8 0.1 -0.2
Tanning 0.0 0.6 1.9 -0.0 0.0 1.0 0.8 -1.4 0.7 -0.4
Hand grip strength (left) 0.9 2.5 5.9 1.8 0.0 -0.8 -2.4 -0.9 1.8 -1.9
Number of treatments/medications taken 1.9 3.4 9.8 2.1 0.0 0.5 -3.1 -0.3 2.1 -2.2
Average weekly spirits intake 0.9 1.1 2.8 0.7 0.0 0.2 -1.3 1.3 1.7 -0.9
Sensitivity / hurt feelings 0.2 0.4 2.0 0.1 0.0 0.6 0.7 1.4 0.1 0.1
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.9 1.0 0.0 -0.2 0.2 -0.0 -0.2 -0.6
Hearing difficulty/problems: Yes 0.4 0.6 2.5 0.5 0.0 -0.2 -1.6 -0.6 -0.9 -0.2
Relative age of first facial hair 0.2 0.4 1.2 -0.7 0.0 -0.6 -0.1 1.1 0.2 0.7
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 7.0 0.4 0.0 2.6 -0.9 0.9 2.4 -1.3
Ever used hormone-replacement therapy (HRT) 1.7 2.2 4.2 2.0 0.0 1.1 -2.0 1.1 1.1 -2.0
Ever had hysterectomy (womb removed) 0.5 0.5 2.9 0.3 0.0 0.3 -0.7 1.7 0.4 -0.3
Systolic blood pressure, automated reading 0.6 1.6 5.7 2.4 0.0 -0.6 -1.3 -0.1 0.4 -1.9
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.0 1.3 0.0 1.0 -0.7 0.9 1.3 -1.4
Angina 0.6 0.7 3.7 0.5 0.0 -0.1 -0.2 1.9 1.0 -0.4
Medication for hormone replacement therapy 0.3 0.3 1.4 0.0 0.0 1.2 0.3 0.7 0.3 -0.5
Vitamin and mineral supplements 0.1 0.1 0.2 -0.3 0.0 -0.1 0.5 -0.4 -0.5 0.1
Supplements: Zinc 0.9 1.0 2.9 0.3 0.0 1.1 -1.1 0.9 1.7 -1.0
Medication: Co-codamol 1.1 1.2 2.0 1.4 0.0 1.4 -1.3 -0.4 1.0 -1.4
Medication: Metformin 0.6 0.8 3.4 0.6 0.0 0.7 -1.8 -0.2 0.9 -0.7
Diabetes (father) 0.6 0.8 2.0 -1.2 0.0 1.4 0.9 0.7 0.8 0.5
Diabetes (mother) 1.5 1.9 3.9 1.7 0.0 2.0 -0.7 0.3 1.9 -1.7
Severe depression (siblings) 0.2 0.3 1.2 0.1 0.0 -0.1 0.0 -1.1 0.8 -0.2
Pack years adult smoking proportion 2.5 3.9 7.7 2.8 0.0 2.0 -2.3 -1.5 1.1 -2.6
Impedance of leg (right) 0.3 1.6 5.9 -0.5 0.0 -1.1 0.6 -0.9 -2.4 1.6
Leg fat-free mass (left) 0.3 1.7 6.1 0.9 0.0 0.4 -0.9 -0.5 2.5 -1.8
Trunk fat percentage 1.9 7.5 15.8 3.0 0.0 1.8 -2.7 -1.2 3.9 -4.0
Hand grip strength (right) 0.2 0.6 2.4 0.2 0.0 -1.6 -0.9 -1.1 0.3 -0.1
Townsend deprivation index at recruitment 0.3 0.4 1.3 -0.5 0.0 -0.2 -0.5 -1.1 -0.9 0.6
Current tobacco smoking 1.1 1.8 4.2 1.7 0.0 1.1 -2.0 -0.5 1.2 -1.6
Average weekly fortified wine intake 0.2 0.2 0.6 -0.7 0.0 0.6 -0.3 0.8 0.1 0.2
Maternal smoking around birth 2.2 3.3 8.6 2.9 0.0 0.8 -2.1 -0.2 1.5 -2.6
Fed-up feelings 0.3 0.5 1.4 1.2 0.0 0.8 0.2 -0.2 0.5 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.1 1.1 0.0 -0.4 -1.0 -0.3 -0.4 -0.5
Relative age voice broke 0.1 0.2 0.6 -0.4 0.0 -0.3 0.5 0.2 0.8 0.1
Taking other prescription medications 2.6 4.0 14.4 2.2 0.0 -0.9 -3.8 -1.1 1.3 -2.1
Age when periods started (menarche) 1.3 3.1 6.5 -1.1 0.0 -2.3 1.7 -1.2 -2.5 2.0
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.7 0.8 0.0 0.8 -1.3 -0.2 0.2 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.9 -0.3 0.0 1.4 0.1 0.4 -0.0 -0.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 3.5 1.7 0.0 0.8 -1.9 -1.1 1.8 -1.9
Qualifications: CSEs or equivalent 3.6 4.7 8.4 2.1 0.0 2.8 -1.4 -1.6 2.9 -2.8
Serious illness, injury or assault to yourself 1.5 1.8 5.2 0.7 0.0 2.3 -0.3 -0.7 2.3 -1.1
High blood pressure 2.7 7.5 14.5 3.5 0.0 0.7 -3.8 -2.8 2.5 -3.4
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.9 -0.5 0.0 0.6 -0.2 -2.0 0.2 0.2
Multivitamins +/- minerals 0.3 0.4 0.9 -0.8 0.0 0.4 1.0 0.9 -0.0 0.7
Stomach or abdominal pain in last month 0.7 0.9 2.3 1.5 0.0 1.1 -0.0 -0.4 0.9 -1.2
Supplements: Glucosamine 0.4 0.6 1.7 0.9 0.0 -0.1 -1.0 0.2 1.3 -0.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.4 0.0 -0.6 -0.7 -0.4 -0.6 -0.3
Medication: Atenolol 0.8 1.0 4.4 2.1 0.0 -0.2 -0.2 -1.0 -0.0 -1.4
Medication: Levothyroxine sodium 1.2 2.0 5.0 1.1 0.0 1.4 -2.2 -0.8 1.6 -1.6
Sitting height 0.3 1.8 5.3 -1.8 0.0 -0.6 2.3 0.4 -0.8 1.7
Chronic bronchitis/emphysema (father) 2.1 2.4 5.3 2.1 0.0 0.6 -1.6 0.0 2.3 -2.1
High blood pressure (mother) 0.2 0.3 1.1 -0.6 0.0 0.9 0.2 -0.3 -0.3 1.0
Body mass index (BMI) 2.8 12.0 24.9 3.9 0.0 1.9 -3.6 -1.4 5.0 -5.0
Impedance of leg (left) 0.3 1.5 5.7 -0.2 0.0 -1.1 -0.1 -1.2 -2.4 1.4
Leg predicted mass (left) 0.3 1.6 6.2 0.9 0.0 0.3 -0.9 -0.6 2.5 -1.8
Trunk fat mass 1.5 6.6 15.1 2.8 0.0 1.3 -2.5 -1.1 3.9 -3.7
Waist circumference 1.4 5.2 12.1 2.8 0.0 1.2 -1.9 -1.4 3.2 -3.5
Number of incorrect matches in round 0.4 0.7 2.3 0.6 0.0 -1.3 -0.2 1.5 -0.3 -0.7
Past tobacco smoking 0.3 0.5 0.8 -0.7 0.0 -0.6 -0.5 0.9 -0.8 0.9
Alcohol usually taken with meals 0.3 0.4 1.9 -0.7 0.0 -0.3 0.4 1.4 0.2 0.5
Nervous feelings 0.5 0.8 4.6 2.1 0.0 -0.4 -0.2 -0.0 -0.6 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.7 0.8 0.0 -0.2 -0.2 0.6 -0.3 -0.5
Hearing difficulty/problems with background noise 0.1 0.2 0.6 0.3 0.0 -0.3 -0.8 -0.7 0.1 -0.1
Hair/balding pattern: Pattern 2 1.5 1.9 4.8 2.0 0.0 0.4 -1.3 -2.2 0.6 -1.6
Had menopause 0.1 0.2 0.7 -0.1 0.0 -0.6 0.1 0.8 -0.3 0.2
Had other major operations 1.0 1.3 5.3 0.0 0.0 2.3 -0.1 1.9 0.4 -0.3
Forced vital capacity (FVC) 0.7 2.5 7.1 -2.5 0.0 -0.8 2.7 0.5 -0.1 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.3 0.6 0.0 1.1 -0.4 0.0 -0.5 -0.5
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.9 1.4 0.0 0.8 -1.0 0.5 1.2 -1.3
Qualifications: None of the above 2.1 4.6 10.7 3.3 0.0 1.2 -2.7 -1.9 1.3 -2.6
Financial difficulties in last 2 years 1.4 1.9 3.2 1.7 0.0 1.8 0.3 -0.7 1.8 -1.8
Mouth/teeth dental problems 0.4 0.6 2.0 0.3 0.0 1.2 0.3 1.4 0.5 -0.7
Heart attack 0.3 0.4 2.2 0.3 0.0 -0.3 0.1 -1.5 -0.0 0.1
Allergy 0.3 0.7 3.0 0.5 0.0 -0.8 1.1 1.7 0.1 -0.3
Pain all over the body in last month 0.9 1.0 2.0 1.3 0.0 1.3 -1.1 0.1 0.5 -1.4
Diabetes (self-reported) 2.1 3.2 6.1 2.1 0.0 0.9 -2.5 -2.0 1.7 -2.1
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 3.7 1.5 0.0 1.5 -1.1 -1.5 1.6 -1.9
Medication: Ramipril 0.8 1.0 5.8 0.4 0.0 0.3 0.2 -2.4 0.9 -0.4
Medication: Simvastatin 0.8 1.2 6.0 1.0 0.0 -0.9 -2.5 0.2 0.4 -0.5
Fluid intelligence score 1.5 3.1 6.2 -2.1 0.0 -2.5 1.8 1.3 -1.8 1.8
Illnesses of siblings 1.6 2.3 4.6 -2.0 0.0 -0.1 1.7 -0.2 -2.1 2.1
Neuroticism score 0.5 1.0 2.2 -0.3 0.0 -0.1 1.5 1.4 -1.4 0.9
Weight 1.2 5.8 14.2 2.6 0.0 1.0 -2.3 -1.4 3.8 -3.4
Impedance of arm (right) 0.4 1.8 4.4 -2.1 0.0 0.4 1.5 0.7 -1.5 1.8
Arm fat percentage (right) 2.9 11.2 26.2 3.5 0.0 2.1 -3.3 -1.2 5.1 -4.8
Trunk fat-free mass 0.1 0.5 1.4 0.2 0.0 -1.2 -0.4 -0.9 1.0 -0.3
Hip circumference 0.9 3.9 7.9 1.9 0.0 -0.3 -2.7 -1.1 2.8 -2.6
Time employed in main current job 1.2 1.4 4.6 -1.7 0.0 0.1 2.2 -0.1 -0.2 1.5
Alcohol intake versus 10 years previously 0.8 1.2 4.6 0.6 0.0 2.1 -1.0 0.6 0.6 -1.2
Father’s age at death 0.3 0.4 1.2 -0.5 0.0 0.5 1.1 1.0 0.5 0.2
Worrier / anxious feelings 0.2 0.4 1.1 0.4 0.0 -0.4 0.8 0.6 -1.1 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.2 1.0 0.0 1.1 -0.9 0.1 0.8 -1.1
Falls in the last year 2.0 2.7 5.6 1.8 0.0 2.4 -1.4 1.6 1.3 -1.9
Hair/balding pattern: Pattern 3 1.4 2.0 3.1 -1.5 0.0 -1.4 1.7 1.5 -1.3 1.8
Number of live births 0.3 0.5 1.5 -0.7 0.0 -1.2 -0.5 -0.2 -0.6 0.8
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.8 -1.7 0.0 -0.4 1.7 -0.3 0.0 1.0
Pulse rate 1.2 2.1 5.3 2.1 0.0 -0.5 -2.3 -1.6 0.2 -1.5
Happiness 0.2 0.2 0.7 0.8 0.0 -0.7 0.0 0.2 -0.1 -0.5
Noisy workplace 5.1 6.3 13.5 3.2 0.0 0.6 -3.7 -1.5 2.8 -3.2
Qualifications: A levels/AS levels or equivalent 0.8 1.8 7.2 -2.7 0.0 -0.7 1.3 0.4 -0.5 1.8
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.7 5.6 -1.6 0.0 -0.9 2.4 -0.1 -0.6 1.5
Mouth/teeth dental problems: Dentures 0.6 0.9 2.4 0.4 0.0 1.5 -1.5 0.1 1.1 -0.8
Asthma 0.5 1.0 4.9 0.6 0.0 0.2 -2.2 -1.1 0.7 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.4 1.2 0.0 0.8 -0.8 0.1 0.6 -0.8
Medication: Cholesterol lowering 0.5 0.8 3.0 -0.3 0.0 -1.7 0.2 -0.8 -0.9 0.8
Depression (self-reported) 0.4 0.5 2.7 -0.5 0.0 -0.5 -0.2 1.6 0.2 0.4
Medication: Lansoprazole 1.2 1.4 3.7 0.7 0.0 1.1 -0.4 -1.9 1.2 -1.7
Prospective memory result 1.7 2.1 4.8 1.6 0.0 1.5 -1.6 -0.5 1.5 -2.2
Lung cancer (father) 0.4 0.5 2.4 0.3 0.0 -0.8 0.4 0.1 -1.6 0.1
Illnesses of mother 0.2 0.2 0.7 0.8 0.0 -0.0 -0.5 0.0 0.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 3.2 -1.8 0.0 -0.4 1.7 0.1 -0.4 1.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 0.3 0.0 1.0 1.2 0.5 0.8 -0.2
Impedance of arm (left) 0.9 3.9 8.3 -2.9 0.0 0.2 2.3 1.1 -2.2 2.8
Arm fat mass (right) 2.4 9.8 23.2 3.3 0.0 1.6 -3.1 -1.3 4.8 -4.5
Trunk predicted mass 0.1 0.5 1.4 0.2 0.0 -1.2 -0.4 -0.9 1.0 -0.3
Standing height 0.5 5.3 11.6 -2.9 0.0 -2.3 2.4 -0.5 -2.4 3.4
Length of working week for main job 1.9 2.1 7.7 0.6 0.0 2.0 0.1 -0.3 2.8 -1.6
Exposure to tobacco smoke at home 0.3 0.3 1.1 -0.1 0.0 -0.5 -0.2 -1.1 -0.7 0.7
Breastfed as a baby 2.2 2.8 5.1 -2.1 0.0 -1.8 1.4 0.7 -2.1 2.2
Tense / ‘highly strung’ 0.2 0.3 1.5 0.6 0.0 -1.2 0.1 0.0 -0.7 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.2 1.1 0.0 0.4 -1.0 0.2 0.3 -0.7
Hair/balding pattern: Pattern 4 0.2 0.5 2.1 -0.5 0.0 0.3 0.8 1.5 0.2 0.3
Birth weight of first child 1.1 2.0 5.0 0.9 0.0 2.2 -0.6 1.5 1.9 -1.3
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.5 0.0 0.8 0.5 -0.5 0.8 -0.1
Pulse wave reflection index 1.8 2.3 8.6 -1.6 0.0 1.2 2.9 1.0 0.1 1.6
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.9 1.7 0.0 0.0 -1.2 -0.3 0.2 -1.3
Loud music exposure frequency 0.1 0.2 0.3 0.5 0.0 -0.5 -0.3 -0.6 0.0 -0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.8 -0.6 0.0 -0.4 0.9 0.4 0.5 0.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.5 0.2 0.0 -0.6 0.5 -0.7 -0.5 0.1
Blood clot in the leg (DVT) 0.4 0.5 1.5 -1.2 0.0 0.1 -0.3 0.4 -1.0 1.0
Medication: Paracetamol 1.0 1.7 3.8 1.5 0.0 0.9 -1.9 -1.7 0.6 -1.5
Headache pain in last month 3.4 5.8 11.1 2.5 0.0 3.3 -2.0 -1.5 2.8 -3.0
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.7 -0.2 0.0 0.8 0.3 0.8 -0.2 -0.1
Glaucoma (self-reported) 1.8 2.1 4.9 1.4 0.0 0.6 -2.2 1.9 1.5 -1.3
Gout (self-reported) 0.2 0.2 0.8 -0.2 0.0 -0.4 -0.9 -0.7 -0.3 0.2
Hypothyroidism/myxoedema (self-reported) 1.2 2.2 6.9 1.4 0.0 0.5 -2.6 -1.2 1.5 -1.7
Medication: Amlodipine 0.5 0.6 3.5 0.5 0.0 -0.5 -0.6 -1.9 -0.2 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.8 -0.5 0.0 0.2 -0.2 1.3 0.5 0.2
Birth weight 0.4 0.8 3.7 -0.2 0.0 0.4 0.1 1.9 1.2 -0.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 3.0 -0.5 0.0 0.4 0.1 1.7 0.3 0.2
High blood pressure (siblings) 1.6 2.3 4.8 1.6 0.0 1.4 -1.6 1.1 2.2 -1.8
Forced vital capacity (FVC), Best measure 0.7 2.4 6.4 -2.4 0.0 -0.8 2.5 0.4 -0.6 1.9
Body fat percentage 2.4 9.4 20.0 3.6 0.0 1.6 -3.2 -1.2 4.3 -4.5
Leg fat percentage (right) 2.9 10.6 21.5 4.1 0.0 1.2 -3.8 -1.2 4.3 -4.6
Arm fat-free mass (right) 0.2 1.0 1.8 1.1 0.0 -0.6 -1.1 -1.3 1.4 -1.1
Exposure to tobacco smoke outside home 1.1 1.5 2.9 1.7 0.0 0.9 -1.6 0.6 1.5 -1.3
Comparative body size at age 10 0.2 0.7 1.3 -1.0 0.0 -1.0 -0.1 1.1 0.8 0.8
Number of full brothers 0.6 0.7 3.3 0.1 0.0 -0.7 0.1 -1.8 -1.0 0.2
Worry too long after embarrassment 1.1 1.8 6.9 -1.0 0.0 -1.0 1.1 0.5 -2.6 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.4 -0.2 0.0 -0.8 -0.6 0.1 -1.2 0.5
Wheeze or whistling in the chest in last year 1.7 3.1 6.0 1.9 0.0 1.5 -2.0 0.4 2.4 -2.4
Number of children fathered 0.9 1.0 4.1 -1.3 0.0 0.4 0.8 2.0 0.7 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.4 0.2 0.0 0.4 0.2 -0.7 1.2 -0.8
Age at first live birth 2.5 4.5 7.7 -2.6 0.0 -1.7 2.7 1.2 -2.3 2.8
Pulse wave peak to peak time 0.5 0.6 1.3 -0.6 0.0 -1.1 -1.1 -0.7 -0.9 0.4
Health satisfaction 3.0 3.9 7.0 2.6 0.0 1.0 -2.6 -1.3 2.0 -2.6
Shortness of breath walking on level ground 1.4 1.6 3.5 1.3 0.0 1.0 -1.9 0.9 1.5 -1.4
Qualifications: College or University degree 4.1 12.8 24.0 -4.9 0.0 -2.6 4.1 1.0 -4.3 4.7
Eye problems/disorders: None of the above 2.5 2.9 4.8 -1.8 0.0 -1.3 2.2 -2.0 -1.8 1.8
Mouth/teeth dental problems: Loose teeth 0.6 0.7 3.9 0.3 0.0 -2.0 -0.1 -0.9 0.3 0.3
Emphysema/chronic bronchitis 0.4 0.4 1.5 0.5 0.0 -0.0 -1.2 -0.5 0.6 -0.7
Medication for pain relief, constipation, heartburn 2.1 3.7 8.0 -2.3 0.0 0.0 2.8 2.8 -1.0 1.9
Neck or shoulder pain in last month 4.5 6.4 11.7 3.4 0.0 1.0 -2.6 -3.0 2.2 -3.4
Medication: Blood pressure 0.1 0.2 0.5 0.6 0.0 -0.7 -0.4 -0.2 0.5 -0.3
Angina (self-reported) 0.7 0.9 3.5 1.0 0.0 0.1 -0.4 1.9 1.1 -0.8
Migraine (self-reported) 0.6 0.8 2.1 -0.4 0.0 1.5 -0.1 -1.5 0.5 0.8
Medication: Ibuprofen 0.5 0.6 1.3 1.1 0.0 0.8 -0.5 0.3 1.0 -1.1
Medication: Allopurinol 0.3 0.3 0.9 -0.9 0.0 -0.6 0.7 0.1 0.2 0.8
Medication: Omeprazole 0.5 0.5 1.5 0.5 0.0 1.2 0.2 0.2 1.1 -0.9
Medication: Seretide 50 evohaler 0.5 0.6 1.8 0.5 0.0 1.3 -1.1 -0.6 0.3 -0.5
Mean time to correctly identify matches 1.3 2.5 6.9 1.7 0.0 -1.4 -2.6 -2.0 -1.0 -1.0
Heart disease (mother) 0.8 1.0 3.0 0.2 0.0 1.7 -0.5 1.7 0.5 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.3 0.1 0.0 -1.5 -1.1 0.3 1.1 -0.4
Whole body fat mass 1.9 7.8 16.8 3.2 0.0 1.1 -2.9 -1.3 4.0 -4.1
Leg fat mass (right) 2.5 9.5 19.7 3.7 0.0 1.1 -3.4 -1.4 4.3 -4.4
Arm predicted mass (right) 0.2 1.0 1.7 1.0 0.0 -0.6 -1.1 -1.1 1.3 -1.1
Pulse rate, automated reading 3.0 9.7 17.4 4.0 0.0 2.7 -3.6 -1.5 3.5 -4.2
Alcohol intake frequency. 1.4 3.4 7.6 2.0 0.0 2.1 -2.8 -0.7 1.5 -2.1
Comparative height size at age 10 0.6 3.4 7.5 -2.5 0.0 0.0 1.9 0.2 -2.6 2.7
Number of full sisters 0.5 0.6 2.4 0.3 0.0 1.1 0.4 -1.6 -0.0 -0.2
Suffer from ‘nerves’ 0.3 0.5 1.4 1.2 0.0 0.1 -0.6 1.2 -0.6 -0.4
Overall health rating 5.9 12.6 25.8 4.9 0.0 3.4 -3.1 -0.4 4.2 -5.1
Chest pain or discomfort 0.3 0.5 2.2 0.3 0.0 0.5 -0.1 -0.1 1.5 -0.8
Had major operations 1.8 2.1 5.9 1.1 0.0 1.9 0.0 1.3 2.4 -1.6
Age at last live birth 3.9 5.6 10.2 -3.1 0.0 -1.7 3.0 0.7 -2.7 3.2
Family relationship satisfaction 0.6 0.8 3.3 -0.6 0.0 -1.8 -0.4 -0.1 -0.7 1.1
Leg pain on walking 6.7 8.4 14.7 3.8 0.0 2.2 -3.8 -1.5 3.1 -3.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.4 0.8 0.0 -0.6 -1.0 -0.2 1.2 -0.9
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.7 -0.0 0.0 -0.3 0.8 0.8 -0.1 0.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.3 -0.7 0.0 -1.8 -0.7 -0.3 -1.5 0.8
Medication: Aspirin 0.2 0.2 0.8 -0.2 0.0 -0.8 -0.9 0.0 0.4 0.3
Supplements: Vitamin C 0.7 0.8 2.5 1.3 0.0 -0.4 -1.6 0.7 -0.0 -0.8
Knee pain experienced in last month 6.6 10.3 22.5 3.8 0.0 3.4 -2.6 -0.6 4.7 -4.1
Hypertension (Self-reported) 2.3 6.4 13.2 3.0 0.0 -0.0 -3.6 -3.0 2.1 -3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.7 -0.3 0.0 0.4 -0.2 -0.1 1.3 -0.4
Illnesses of father: Heart disease 0.4 0.6 3.5 0.4 0.0 -0.6 -0.4 -1.9 -0.1 -0.2
Illnesses of siblings: Diabetes 1.6 1.9 4.3 1.6 0.0 1.4 -2.1 -0.2 0.9 -1.9
Smoking status: Previous 0.4 0.6 1.4 0.6 0.0 1.0 1.2 -0.3 0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 5.6 -2.4 0.0 -0.1 2.0 -0.6 -0.9 2.3
Whole body fat-free mass 0.1 0.8 2.8 0.6 0.0 -0.5 -0.8 -0.9 1.7 -1.0
Leg fat-free mass (right) 0.3 1.4 5.2 0.7 0.0 0.4 -0.9 -0.5 2.3 -1.6
Arm fat percentage (left) 2.4 9.6 22.7 3.3 0.0 2.0 -3.0 -0.9 4.8 -4.5
Average weekly red wine intake 0.3 0.5 1.9 0.0 0.0 -1.4 0.5 -1.0 -0.5 -0.0
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.0 1.8 0.0 0.5 -2.2 -0.4 1.1 -1.7
Mood swings 0.1 0.2 0.5 0.5 0.0 0.7 0.7 -0.2 0.2 -0.3
Loneliness, isolation 0.6 0.8 3.0 -0.3 0.0 -0.4 1.2 -0.6 -1.7 0.7
Long-standing illness, disability or infirmity 5.1 7.9 13.6 3.5 0.0 2.3 -3.2 -1.2 3.5 -3.7
Ever had bowel cancer screening 1.4 1.6 9.0 -1.0 0.0 -0.3 -0.8 3.0 -0.6 0.5
Diabetes diagnosed by doctor 2.1 3.4 5.8 2.3 0.0 1.3 -2.4 -1.3 2.1 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 2.1 -1.3 0.0 -0.8 0.4 1.0 -0.6 1.4
Friendships satisfaction 1.1 1.3 2.8 -1.5 0.0 -0.4 1.6 0.5 -1.1 1.7
Qualifications: nursing, teaching 0.6 0.9 2.6 -1.2 0.0 -0.8 0.4 -0.2 -1.6 1.3
Commuting to job workplace: Walk 3.0 3.2 8.5 -1.8 0.0 -2.1 1.1 -2.9 -1.5 1.8
Eye problems/disorders: Cataract 0.9 1.0 5.3 1.0 0.0 -0.2 -2.3 0.6 0.7 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 0.6 0.0 -0.3 0.3 -1.0 0.5 -0.3
Medication for cholesterol 2.9 4.4 8.7 -3.0 0.0 -1.7 2.9 0.6 -1.6 2.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.4 4.0 13.8 2.4 0.0 0.1 -3.7 -1.4 1.7 -1.9
Back pain experienced in last month 2.3 3.3 5.5 2.0 0.0 1.4 -2.0 -2.3 1.9 -2.0
Mineral and other dietary supplements 0.7 1.0 4.9 -0.5 0.0 1.2 2.2 0.1 -0.5 0.0
Breast cancer (self-reported) 0.7 0.8 2.4 0.8 0.0 0.7 -1.2 1.6 0.4 -0.6
Asthma (self-reported) 0.4 0.8 4.7 0.4 0.0 0.1 -2.2 -0.7 0.4 -0.4
Osteoporosis (self-reported) 0.6 0.8 3.5 0.9 0.0 0.2 -0.4 -1.9 0.3 -0.8
Osteoarthritis (self-reported) 4.5 5.8 14.7 1.9 0.0 3.4 -1.4 0.5 3.8 -2.9
Medication: Aspirin 0.2 0.2 0.9 -0.1 0.0 -0.6 -1.0 -0.3 0.4 0.2
Medication: Gliclazide 0.2 0.3 0.5 0.7 0.0 0.3 -0.1 -0.5 0.7 -0.7
Illnesses of father: None of the above (group 1) 0.6 0.7 1.6 -0.7 0.0 -0.1 1.0 0.4 -1.2 1.3
Smoking status: Current 1.0 1.6 4.8 1.7 0.0 0.4 -2.2 -1.0 0.7 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.1 -1.1 0.0 -0.5 0.2 -0.1 -0.0 0.7
Whole body water mass 0.2 0.9 2.7 0.7 0.0 -0.6 -0.9 -1.0 1.6 -1.1
Leg predicted mass (right) 0.3 1.4 5.6 0.7 0.0 0.4 -0.9 -0.4 2.4 -1.6
Arm fat mass (left) 2.0 8.1 19.6 3.0 0.0 1.4 -2.9 -1.3 4.4 -4.0
Number of self-reported non-cancer illnesses 3.0 5.1 15.5 2.4 0.0 0.2 -3.9 -1.4 2.1 -2.8
Average weekly champagne plus white wine intake 2.0 2.8 6.9 -2.6 0.0 -0.0 2.4 1.1 -1.3 2.1
Miserableness 0.4 0.6 2.5 1.1 0.0 0.6 0.3 -1.6 -0.1 -0.4
Guilty feelings 1.0 1.5 2.9 -1.0 0.0 -0.9 1.6 1.3 -1.7 1.4
Wears glasses or contact lenses 0.4 0.4 1.8 -1.3 0.0 -0.1 0.3 0.7 -0.1 0.9
Ever taken oral contraceptive pill 0.5 0.6 2.8 0.8 0.0 -0.2 1.7 0.5 -0.4 -0.5
Hearing aid user 1.2 1.3 4.6 0.1 0.0 -0.6 -0.9 -2.1 -1.8 0.6
Mother’s age at death 3.1 3.8 8.2 -2.9 0.0 -1.0 2.4 1.1 -1.6 2.8
Financial situation satisfaction 0.3 0.3 0.9 0.9 0.0 -0.6 -0.5 -0.2 0.2 -0.8
Tinnitus: Yes, now most or all of the time 1.1 1.3 2.0 -1.1 0.0 -1.3 1.3 -0.8 -1.3 1.4
Commuting to job workplace: Public transport 0.3 0.4 2.0 -0.5 0.0 0.8 0.0 0.2 1.4 0.3
Eye problems/disorders: Glaucoma 0.9 1.1 2.7 0.7 0.0 0.5 -1.6 1.6 1.2 -0.6
Medication: Blood pressure 3.2 6.1 11.7 3.4 0.0 0.8 -3.4 -2.1 2.1 -3.1
Pain type(s) experienced in last month: Hip pain 2.5 3.1 7.5 2.7 0.0 1.3 -1.9 -1.5 1.7 -2.0
Supplements: Fish oil (including cod liver oil) 0.9 1.1 4.0 0.1 0.0 -1.9 -2.0 -0.2 0.0 0.6
High cholesterol (Self-reported) 0.3 0.6 2.9 0.2 0.0 -1.7 -0.8 0.2 -0.4 0.3
Medication: Bendroflumethiazide 1.1 1.7 3.2 1.8 0.0 0.8 -1.8 -1.2 0.9 -1.5
Medication: Paracetamol 1.3 2.0 4.6 1.8 0.0 0.6 -2.1 -1.1 1.0 -1.9
Medication: Lisinopril 0.4 0.5 2.8 -0.0 0.0 -0.3 -1.7 0.8 0.1 0.2
Medication: Atorvastatin 0.3 0.4 1.2 0.4 0.0 1.1 0.3 -0.9 0.3 -0.6
Illnesses of father: High blood pressure 0.7 0.9 2.8 -0.0 0.0 1.1 0.3 1.2 1.7 -0.8
Alcohol drinker status: Never 0.5 0.6 3.2 0.2 0.0 0.2 -0.4 -1.8 0.6 -0.3
Ever smoked 0.4 0.7 1.2 1.0 0.0 0.6 -0.5 -1.1 0.9 -1.0
Basal metabolic rate 0.3 1.8 5.5 1.2 0.0 -0.1 -1.2 -1.1 2.3 -1.8
Leg fat percentage (left) 3.1 11.4 22.5 4.2 0.0 1.2 -4.3 -1.2 4.3 -4.7
Arm fat-free mass (left) 0.4 2.2 3.7 1.6 0.0 -0.6 -1.8 -1.5 1.9 -1.7
Number of operations (self-reported) 4.7 7.0 13.1 2.4 0.0 3.6 -2.0 2.7 3.2 -2.9
Average weekly beer plus cider intake 1.2 1.7 4.2 1.5 0.0 2.0 -0.7 -0.8 1.2 -1.8
Irritability 4.3 7.3 15.2 -3.4 0.0 -1.5 3.9 1.5 -2.6 3.6
Risk taking 0.8 1.2 2.1 -1.3 0.0 0.1 1.3 0.9 -1.5 1.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.7 -0.8 0.0 -0.5 0.1 1.6 -0.3 1.0
Fractured/broken bones in last 5 years 1.0 1.3 2.9 1.5 0.0 0.7 -1.7 0.5 1.0 -1.6
Age started oral contraceptive pill 0.4 0.5 1.6 -0.6 0.0 -0.8 0.2 -0.3 -1.2 0.8
Diastolic blood pressure, automated reading 0.8 2.4 7.0 0.6 0.0 1.7 0.8 2.6 1.8 -1.5
Ever depressed for a whole week 0.8 1.0 2.2 1.5 0.0 1.1 -1.0 0.9 0.6 -1.2
Unable to work because of sickness or disability 4.7 6.1 13.6 3.7 0.0 1.9 -1.9 -2.5 2.2 -3.2
Commuting to job workplace: Cycle 0.4 0.4 0.9 -0.8 0.0 -0.0 -0.7 0.9 -0.6 1.0
Myopia 0.4 0.6 1.3 -1.1 0.0 -0.7 1.0 0.1 -0.9 0.9
Vascular/heart problems diagnosed by doctor 2.2 6.1 9.8 -3.1 0.0 -0.5 3.1 2.8 -2.3 3.1
Cholesterol lowering medication 2.6 3.8 8.8 2.8 0.0 0.7 -3.0 0.1 1.7 -2.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 2.2 0.6 0.0 1.5 -0.2 -0.2 0.9 -1.0
Pain experienced in last month 8.2 13.7 23.5 -4.5 0.0 -3.4 3.8 2.0 -4.8 4.7
Supplements: Calcium 0.2 0.3 1.1 0.2 0.0 0.4 0.2 -0.6 1.0 -0.3
Basal cell carcinoma (self-reported) 0.7 0.9 3.2 -0.4 0.0 -1.8 -0.3 -0.3 -1.4 0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.5 0.1 0.0 -0.5 0.3 -1.2 0.0 0.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 -0.9 0.0 0.3 -0.1 0.4 -0.6 0.6
Heart disease (siblings) 0.2 0.3 0.8 0.3 0.0 -0.9 -0.5 -0.8 0.0 -0.2
Alcohol drinker status: Previous 0.7 0.8 1.5 1.1 0.0 1.2 -0.6 -1.0 0.5 -0.9
Pack years of smoking 2.5 3.6 7.8 2.8 0.0 1.7 -2.4 -1.5 0.7 -2.5
Impedance of whole body 0.4 2.1 5.7 -1.6 0.0 -0.4 1.4 -0.1 -2.4 2.1
Leg fat mass (left) 2.5 9.9 20.1 3.8 0.0 1.2 -3.7 -1.4 4.2 -4.5
Arm predicted mass (left) 0.5 2.3 4.3 1.6 0.0 -0.5 -1.8 -1.6 2.1 -1.8