TWAS hub - TSKU

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.4310	0.1130	1.7e-03	0.154	NA	0.079	NA	0.147	9.0e-05	NA	4.5e-03	NA	1.3e-04
2	GTEx	Muscle Skeletal	0.2886	0.0603	2.9e-05	-0.003	NA	-0.002	NA	-0.003	8.8e-01	NA	7.4e-01	NA	8.6e-01
3	GTEx	Skin Sun Exposed Lower leg	0.1570	0.0490	1.8e-03	0.042	NA	0.039	NA	0.032	2.2e-04	NA	3.2e-04	NA	1.1e-03
4	METSIM	Adipose	0.0725	0.0260	4.1e-04	0.009	0.017	0.024	0.024	0.024	1.3e-02	1.1e-03	1.2e-04	1.5e-04	1.2e-04
5	ROSMAP	Brain Pre-frontal Cortex	0.1198	0.0320	3.3e-06	0.047	0.055	0.067	0.065	0.072	9.3e-07	1.1e-07	5.9e-09	1.0e-08	1.5e-09
6	TCGA	Pancreatic Adenocarcinoma	0.0930	0.0450	4.4e-03	0.028	0.069	0.017	NA	0.028	2.4e-02	7.5e-04	6.0e-02	NA	2.5e-02
7	TCGA	Thyroid Carcinoma	0.0560	0.0300	3.9e-03	0.031	0.014	0.007	NA	0.019	4.7e-04	1.6e-02	6.1e-02	NA	5.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6	7
Pain experienced in last month	8.2	13.7	23.5	-4.5	-3.4	3.8	2.0	-4.8	4.7
Leg pain on walking	6.7	8.4	14.7	3.8	2.2	-3.8	-1.5	3.1	-3.5
Knee pain experienced in last month	6.6	10.3	22.5	3.8	3.4	-2.6	-0.6	4.7	-4.1
Overall health rating	5.9	12.6	25.8	4.9	3.4	-3.1	-0.4	4.2	-5.1
Noisy workplace	5.1	6.3	13.5	3.2	0.6	-3.7	-1.5	2.8	-3.2
Long-standing illness, disability or infirmity	5.1	7.9	13.6	3.5	2.3	-3.2	-1.2	3.5	-3.7
Number of operations (self-reported)	4.7	7.0	13.1	2.4	3.6	-2.0	2.7	3.2	-2.9
Unable to work because of sickness or disability	4.7	6.1	13.6	3.7	1.9	-1.9	-2.5	2.2	-3.2
Neck or shoulder pain in last month	4.5	6.4	11.7	3.4	1.0	-2.6	-3.0	2.2	-3.4
Osteoarthritis (self-reported)	4.5	5.8	14.7	1.9	3.4	-1.4	0.5	3.8	-2.9
Irritability	4.3	7.3	15.2	-3.4	-1.5	3.9	1.5	-2.6	3.6
Qualifications: College or University degree	4.1	12.8	24.0	-4.9	-2.6	4.1	1.0	-4.3	4.7
Age at last live birth	3.9	5.6	10.2	-3.1	-1.7	3.0	0.7	-2.7	3.2
Qualifications: CSEs or equivalent	3.6	4.7	8.4	2.1	2.8	-1.4	-1.6	2.9	-2.8
BMI	3.4	19.5	39.8	5.0	2.8	-4.7	-1.8	6.2	-6.3
Type 2 Diabetes (T2D) (2018)	3.4	6.3	11.5	3.1	2.4	-2.5	-0.7	3.2	-3.4
Headache pain in last month	3.4	5.8	11.1	2.5	3.3	-2.0	-1.5	2.8	-3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.4	4.0	13.8	2.4	0.1	-3.7	-1.4	1.7	-1.9
Major Depression (MDD)	3.2	3.8	8.5	2.9	2.1	-2.0	-0.3	1.5	-2.8
Medication: Blood pressure	3.2	6.1	11.7	3.4	0.8	-3.4	-2.1	2.1	-3.1
Mother’s age at death	3.1	3.8	8.2	-2.9	-1.0	2.4	1.1	-1.6	2.8
Leg fat percentage (left)	3.1	11.4	22.5	4.2	1.2	-4.3	-1.2	4.3	-4.7
Health satisfaction	3.0	3.9	7.0	2.6	1.0	-2.6	-1.3	2.0	-2.6
Pulse rate, automated reading	3.0	9.7	17.4	4.0	2.7	-3.6	-1.5	3.5	-4.2
Commuting to job workplace: Walk	3.0	3.2	8.5	-1.8	-2.1	1.1	-2.9	-1.5	1.8
Number of self-reported non-cancer illnesses	3.0	5.1	15.5	2.4	0.2	-3.9	-1.4	2.1	-2.8
Hypothyroidism (self reported)	2.9	6.7	15.9	3.0	0.9	-4.0	-2.7	2.4	-2.9
Arm fat percentage (right)	2.9	11.2	26.2	3.5	2.1	-3.3	-1.2	5.1	-4.8
Leg fat percentage (right)	2.9	10.6	21.5	4.1	1.2	-3.8	-1.2	4.3	-4.6
Medication for cholesterol	2.9	4.4	8.7	-3.0	-1.7	2.9	0.6	-1.6	2.8
Body mass index (BMI)	2.8	12.0	24.9	3.9	1.9	-3.6	-1.4	5.0	-5.0
High blood pressure	2.7	7.5	14.5	3.5	0.7	-3.8	-2.8	2.5	-3.4
Taking other prescription medications	2.6	4.0	14.4	2.2	-0.9	-3.8	-1.1	1.3	-2.1
Cholesterol lowering medication	2.6	3.8	8.8	2.8	0.7	-3.0	0.1	1.7	-2.5
Pack years adult smoking proportion	2.5	3.9	7.7	2.8	2.0	-2.3	-1.5	1.1	-2.6
Age at first live birth	2.5	4.5	7.7	-2.6	-1.7	2.7	1.2	-2.3	2.8
Eye problems/disorders: None of the above	2.5	2.9	4.8	-1.8	-1.3	2.2	-2.0	-1.8	1.8
Leg fat mass (right)	2.5	9.5	19.7	3.7	1.1	-3.4	-1.4	4.3	-4.4
Pain type(s) experienced in last month: Hip pain	2.5	3.1	7.5	2.7	1.3	-1.9	-1.5	1.7	-2.0
Pack years of smoking	2.5	3.6	7.8	2.8	1.7	-2.4	-1.5	0.7	-2.5
Leg fat mass (left)	2.5	9.9	20.1	3.8	1.2	-3.7	-1.4	4.2	-4.5
Bipolar Disorder (2018)	2.4	3.7	8.9	-2.3	-1.6	3.0	1.5	-1.9	1.9
Arm fat mass (right)	2.4	9.8	23.2	3.3	1.6	-3.1	-1.3	4.8	-4.5
Body fat percentage	2.4	9.4	20.0	3.6	1.6	-3.2	-1.2	4.3	-4.5
Arm fat percentage (left)	2.4	9.6	22.7	3.3	2.0	-3.0	-0.9	4.8	-4.5
Intelligence (Savage-Jansen 2018)	2.3	7.1	12.1	-3.4	-3.3	1.9	0.2	-3.5	3.3
Rheumatoid Arthritis	2.3	3.1	6.7	2.4	0.9	-1.2	-1.1	2.4	-2.6
Hypertension (Self-reported)	2.3	6.4	13.2	3.0	-0.0	-3.6	-3.0	2.1	-3.0
Back pain experienced in last month	2.3	3.3	5.5	2.0	1.4	-2.0	-2.3	1.9	-2.0
Age at First Birth	2.2	3.3	6.9	-2.2	-0.4	2.0	2.6	-1.6	2.1
Maternal smoking around birth	2.2	3.3	8.6	2.9	0.8	-2.1	-0.2	1.5	-2.6
Breastfed as a baby	2.2	2.8	5.1	-2.1	-1.8	1.4	0.7	-2.1	2.2
Vascular/heart problems diagnosed by doctor	2.2	6.1	9.8	-3.1	-0.5	3.1	2.8	-2.3	3.1
HDL Cholesterol	2.1	3.5	7.7	-2.8	-0.4	2.2	1.1	-1.9	2.6
Cardiovascular Disease	2.1	6.8	12.4	3.5	0.4	-3.4	-2.6	2.5	-3.3
Chronic bronchitis/emphysema (father)	2.1	2.4	5.3	2.1	0.6	-1.6	0.0	2.3	-2.1
Qualifications: None of the above	2.1	4.6	10.7	3.3	1.2	-2.7	-1.9	1.3	-2.6
Diabetes (self-reported)	2.1	3.2	6.1	2.1	0.9	-2.5	-2.0	1.7	-2.1
Medication for pain relief, constipation, heartburn	2.1	3.7	8.0	-2.3	0.0	2.8	2.8	-1.0	1.9
Diabetes diagnosed by doctor	2.1	3.4	5.8	2.3	1.3	-2.4	-1.3	2.1	-2.2
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.5	1.7	0.8	-1.9	-1.1	1.8	-1.9
Falls in the last year	2.0	2.7	5.6	1.8	2.4	-1.4	1.6	1.3	-1.9
Arm fat mass (left)	2.0	8.1	19.6	3.0	1.4	-2.9	-1.3	4.4	-4.0
Average weekly champagne plus white wine intake	2.0	2.8	6.9	-2.6	-0.0	2.4	1.1	-1.3	2.1
Number of treatments/medications taken	1.9	3.4	9.8	2.1	0.5	-3.1	-0.3	2.1	-2.2
Trunk fat percentage	1.9	7.5	15.8	3.0	1.8	-2.7	-1.2	3.9	-4.0
Length of working week for main job	1.9	2.1	7.7	0.6	2.0	0.1	-0.3	2.8	-1.6
Whole body fat mass	1.9	7.8	16.8	3.2	1.1	-2.9	-1.3	4.0	-4.1
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	7.0	0.4	2.6	-0.9	0.9	2.4	-1.3
Pulse wave reflection index	1.8	2.3	8.6	-1.6	1.2	2.9	1.0	0.1	1.6
Glaucoma (self-reported)	1.8	2.1	4.9	1.4	0.6	-2.2	1.9	1.5	-1.3
Had major operations	1.8	2.1	5.9	1.1	1.9	0.0	1.3	2.4	-1.6
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.2	2.0	1.1	-2.0	1.1	1.1	-2.0
Prospective memory result	1.7	2.1	4.8	1.6	1.5	-1.6	-0.5	1.5	-2.2
Wheeze or whistling in the chest in last year	1.7	3.1	6.0	1.9	1.5	-2.0	0.4	2.4	-2.4
Verbal and Numeric Reasoning (VNR)	1.6	4.0	9.4	-2.3	-3.1	1.6	0.7	-2.4	2.2
Illnesses of siblings	1.6	2.3	4.6	-2.0	-0.1	1.7	-0.2	-2.1	2.1
High blood pressure (siblings)	1.6	2.3	4.8	1.6	1.4	-1.6	1.1	2.2	-1.8
Illnesses of siblings: Diabetes	1.6	1.9	4.3	1.6	1.4	-2.1	-0.2	0.9	-1.9
Diabetes (mother)	1.5	1.9	3.9	1.7	2.0	-0.7	0.3	1.9	-1.7
Serious illness, injury or assault to yourself	1.5	1.8	5.2	0.7	2.3	-0.3	-0.7	2.3	-1.1
Trunk fat mass	1.5	6.6	15.1	2.8	1.3	-2.5	-1.1	3.9	-3.7
Hair/balding pattern: Pattern 2	1.5	1.9	4.8	2.0	0.4	-1.3	-2.2	0.6	-1.6
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.7	1.5	1.5	-1.1	-1.5	1.6	-1.9
Fluid intelligence score	1.5	3.1	6.2	-2.1	-2.5	1.8	1.3	-1.8	1.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.0	1.8	0.5	-2.2	-0.4	1.1	-1.7
Bipolar Disorder or Schizophrenia	1.4	3.4	5.5	-2.2	-1.9	2.3	0.4	-2.3	2.1
Reaction Time	1.4	2.7	7.0	1.9	-0.5	-2.4	-2.6	-0.5	-1.4
Bipolar Disorder (2011)	1.4	1.4	5.2	-1.0	-0.7	2.3	0.7	-1.1	1.1
Triglycerides	1.4	2.3	5.1	2.2	0.3	-2.2	-0.9	1.2	-2.0
Waist circumference	1.4	5.2	12.1	2.8	1.2	-1.9	-1.4	3.2	-3.5
Financial difficulties in last 2 years	1.4	1.9	3.2	1.7	1.8	0.3	-0.7	1.8	-1.8
Hair/balding pattern: Pattern 3	1.4	2.0	3.1	-1.5	-1.4	1.7	1.5	-1.3	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	5.6	-1.6	-0.9	2.4	-0.1	-0.6	1.5
Shortness of breath walking on level ground	1.4	1.6	3.5	1.3	1.0	-1.9	0.9	1.5	-1.4
Alcohol intake frequency.	1.4	3.4	7.6	2.0	2.1	-2.8	-0.7	1.5	-2.1
Ever had bowel cancer screening	1.4	1.6	9.0	-1.0	-0.3	-0.8	3.0	-0.6	0.5
Fasting Glucose	1.3	1.5	3.5	0.5	1.2	-1.6	0.7	1.9	-1.6
Age when periods started (menarche)	1.3	3.1	6.5	-1.1	-2.3	1.7	-1.2	-2.5	2.0
Mean time to correctly identify matches	1.3	2.5	6.9	1.7	-1.4	-2.6	-2.0	-1.0	-1.0
Medication: Paracetamol	1.3	2.0	4.6	1.8	0.6	-2.1	-1.1	1.0	-1.9
Medication: Levothyroxine sodium	1.2	2.0	5.0	1.1	1.4	-2.2	-0.8	1.6	-1.6
Weight	1.2	5.8	14.2	2.6	1.0	-2.3	-1.4	3.8	-3.4
Time employed in main current job	1.2	1.4	4.6	-1.7	0.1	2.2	-0.1	-0.2	1.5
Pulse rate	1.2	2.1	5.3	2.1	-0.5	-2.3	-1.6	0.2	-1.5
Medication: Lansoprazole	1.2	1.4	3.7	0.7	1.1	-0.4	-1.9	1.2	-1.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.2	6.9	1.4	0.5	-2.6	-1.2	1.5	-1.7
Hearing aid user	1.2	1.3	4.6	0.1	-0.6	-0.9	-2.1	-1.8	0.6
Average weekly beer plus cider intake	1.2	1.7	4.2	1.5	2.0	-0.7	-0.8	1.2	-1.8
Prostate Cancer	1.1	1.5	3.0	-1.4	-1.5	0.6	0.5	-1.7	1.6
Medication: Co-codamol	1.1	1.2	2.0	1.4	1.4	-1.3	-0.4	1.0	-1.4
Current tobacco smoking	1.1	1.8	4.2	1.7	1.1	-2.0	-0.5	1.2	-1.6
Birth weight of first child	1.1	2.0	5.0	0.9	2.2	-0.6	1.5	1.9	-1.3
Exposure to tobacco smoke outside home	1.1	1.5	2.9	1.7	0.9	-1.6	0.6	1.5	-1.3
Worry too long after embarrassment	1.1	1.8	6.9	-1.0	-1.0	1.1	0.5	-2.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.6	-2.4	-0.1	2.0	-0.6	-0.9	2.3
Friendships satisfaction	1.1	1.3	2.8	-1.5	-0.4	1.6	0.5	-1.1	1.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.0	-1.1	-1.3	1.3	-0.8	-1.3	1.4
Medication: Bendroflumethiazide	1.1	1.7	3.2	1.8	0.8	-1.8	-1.2	0.9	-1.5
Schizophrenia (2014)	1.0	2.3	5.5	-1.8	-1.6	1.3	-0.0	-2.4	1.8
Systolic Blood Pressure	1.0	5.1	15.1	3.9	1.0	-1.9	-1.4	1.6	-3.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	1.3	1.0	-0.7	0.9	1.3	-1.4
Had other major operations	1.0	1.3	5.3	0.0	2.3	-0.1	1.9	0.4	-0.3
Medication: Paracetamol	1.0	1.7	3.8	1.5	0.9	-1.9	-1.7	0.6	-1.5
Smoking status: Current	1.0	1.6	4.8	1.7	0.4	-2.2	-1.0	0.7	-1.3
Guilty feelings	1.0	1.5	2.9	-1.0	-0.9	1.6	1.3	-1.7	1.4
Fractured/broken bones in last 5 years	1.0	1.3	2.9	1.5	0.7	-1.7	0.5	1.0	-1.6
Smoking Status	0.9	2.2	5.3	2.3	1.0	-1.4	-1.6	1.1	-1.9
Respiratory disease	0.9	1.9	6.5	1.5	0.6	-2.6	-0.1	1.4	-1.5
Hand grip strength (left)	0.9	2.5	5.9	1.8	-0.8	-2.4	-0.9	1.8	-1.9
Average weekly spirits intake	0.9	1.1	2.8	0.7	0.2	-1.3	1.3	1.7	-0.9
Supplements: Zinc	0.9	1.0	2.9	0.3	1.1	-1.1	0.9	1.7	-1.0
Pain all over the body in last month	0.9	1.0	2.0	1.3	1.3	-1.1	0.1	0.5	-1.4
Hip circumference	0.9	3.9	7.9	1.9	-0.3	-2.7	-1.1	2.8	-2.6
Impedance of arm (left)	0.9	3.9	8.3	-2.9	0.2	2.3	1.1	-2.2	2.8
Number of children fathered	0.9	1.0	4.1	-1.3	0.4	0.8	2.0	0.7	0.5
Eye problems/disorders: Cataract	0.9	1.0	5.3	1.0	-0.2	-2.3	0.6	0.7	-0.4
Eye problems/disorders: Glaucoma	0.9	1.1	2.7	0.7	0.5	-1.6	1.6	1.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.0	0.1	-1.9	-2.0	-0.2	0.0	0.6
Alzheimer’s Disease (in mother)	0.8	0.9	2.5	1.2	-0.5	-0.5	-1.6	1.0	-1.0
Alzheimer’s Disease (in father)	0.8	0.9	1.8	-0.7	-1.0	1.2	0.8	-1.3	0.9
Ovarian Cancer	0.8	1.1	2.7	0.8	1.6	-1.3	1.0	0.7	-1.1
Medication: Atenolol	0.8	1.0	4.4	2.1	-0.2	-0.2	-1.0	-0.0	-1.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.9	1.4	0.8	-1.0	0.5	1.2	-1.3
Medication: Ramipril	0.8	1.0	5.8	0.4	0.3	0.2	-2.4	0.9	-0.4
Medication: Simvastatin	0.8	1.2	6.0	1.0	-0.9	-2.5	0.2	0.4	-0.5
Alcohol intake versus 10 years previously	0.8	1.2	4.6	0.6	2.1	-1.0	0.6	0.6	-1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	7.2	-2.7	-0.7	1.3	0.4	-0.5	1.8
Heart disease (mother)	0.8	1.0	3.0	0.2	1.7	-0.5	1.7	0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.3	-0.7	-1.8	-0.7	-0.3	-1.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.1	-1.3	-0.8	0.4	1.0	-0.6	1.4
Risk taking	0.8	1.2	2.1	-1.3	0.1	1.3	0.9	-1.5	1.4
Diastolic blood pressure, automated reading	0.8	2.4	7.0	0.6	1.7	0.8	2.6	1.8	-1.5
Ever depressed for a whole week	0.8	1.0	2.2	1.5	1.1	-1.0	0.9	0.6	-1.2
Coronary Artery Disease (CAD)	0.7	0.9	3.7	0.5	-1.2	-1.9	-0.8	0.1	-0.2
HbA1C	0.7	0.8	2.4	-1.2	0.8	0.0	1.5	-0.5	0.8
Neuroticism (2016)	0.7	1.1	4.4	1.3	0.4	0.8	-2.1	0.4	-0.7
Stomach or abdominal pain in last month	0.7	0.9	2.3	1.5	1.1	-0.0	-0.4	0.9	-1.2
Forced vital capacity (FVC)	0.7	2.5	7.1	-2.5	-0.8	2.7	0.5	-0.1	1.8
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.9	1.7	0.0	-1.2	-0.3	0.2	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.4	6.4	-2.4	-0.8	2.5	0.4	-0.6	1.9
Angina (self-reported)	0.7	0.9	3.5	1.0	0.1	-0.4	1.9	1.1	-0.8
Supplements: Vitamin C	0.7	0.8	2.5	1.3	-0.4	-1.6	0.7	-0.0	-0.8
Mineral and other dietary supplements	0.7	1.0	4.9	-0.5	1.2	2.2	0.1	-0.5	0.0
Breast cancer (self-reported)	0.7	0.8	2.4	0.8	0.7	-1.2	1.6	0.4	-0.6
Illnesses of father: High blood pressure	0.7	0.9	2.8	-0.0	1.1	0.3	1.2	1.7	-0.8
Basal cell carcinoma (self-reported)	0.7	0.9	3.2	-0.4	-1.8	-0.3	-0.3	-1.4	0.8
Alcohol drinker status: Previous	0.7	0.8	1.5	1.1	1.2	-0.6	-1.0	0.5	-0.9
Alzheimer’s Disease (including proxy)	0.6	0.8	2.3	1.5	0.3	-0.2	-0.6	1.0	-1.4
Breast Cancer	0.6	1.4	3.2	1.8	-0.4	-1.1	-1.8	0.6	-1.4
Heel T-Score	0.6	4.6	19.2	0.5	4.4	-0.8	1.4	2.8	-1.6
Lung FEV1/FVC ratio	0.6	3.0	11.8	1.9	1.0	-3.4	-0.8	0.9	-1.8
Neuroticism	0.6	1.5	3.8	-0.5	-1.0	1.5	1.3	-1.9	1.1
Systolic blood pressure, automated reading	0.6	1.6	5.7	2.4	-0.6	-1.3	-0.1	0.4	-1.9
Angina	0.6	0.7	3.7	0.5	-0.1	-0.2	1.9	1.0	-0.4
Medication: Metformin	0.6	0.8	3.4	0.6	0.7	-1.8	-0.2	0.9	-0.7
Diabetes (father)	0.6	0.8	2.0	-1.2	1.4	0.9	0.7	0.8	0.5
Mouth/teeth dental problems: Dentures	0.6	0.9	2.4	0.4	1.5	-1.5	0.1	1.1	-0.8
Number of full brothers	0.6	0.7	3.3	0.1	-0.7	0.1	-1.8	-1.0	0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	3.9	0.3	-2.0	-0.1	-0.9	0.3	0.3
Migraine (self-reported)	0.6	0.8	2.1	-0.4	1.5	-0.1	-1.5	0.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.3	0.1	-1.5	-1.1	0.3	1.1	-0.4
Comparative height size at age 10	0.6	3.4	7.5	-2.5	0.0	1.9	0.2	-2.6	2.7
Family relationship satisfaction	0.6	0.8	3.3	-0.6	-1.8	-0.4	-0.1	-0.7	1.1
Loneliness, isolation	0.6	0.8	3.0	-0.3	-0.4	1.2	-0.6	-1.7	0.7
Qualifications: nursing, teaching	0.6	0.9	2.6	-1.2	-0.8	0.4	-0.2	-1.6	1.3
Osteoporosis (self-reported)	0.6	0.8	3.5	0.9	0.2	-0.4	-1.9	0.3	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	-0.7	-0.1	1.0	0.4	-1.2	1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.7	-0.8	-0.5	0.1	1.6	-0.3	1.0
Neuroticism (Nagel 2018)	0.5	1.1	4.2	-0.3	-0.9	1.3	-0.2	-2.0	1.1
Mean Putamen Volume	0.5	0.6	2.3	-0.3	1.2	0.5	0.1	1.5	-0.2
Ulcerative Colitis	0.5	0.8	2.5	-1.0	0.3	0.9	1.6	-0.4	0.9
Ever had hysterectomy (womb removed)	0.5	0.5	2.9	0.3	0.3	-0.7	1.7	0.4	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	0.8	0.8	-1.3	-0.2	0.2	-1.0
Nervous feelings	0.5	0.8	4.6	2.1	-0.4	-0.2	-0.0	-0.6	-0.8
Neuroticism score	0.5	1.0	2.2	-0.3	-0.1	1.5	1.4	-1.4	0.9
Asthma	0.5	1.0	4.9	0.6	0.2	-2.2	-1.1	0.7	-0.6
Medication: Cholesterol lowering	0.5	0.8	3.0	-0.3	-1.7	0.2	-0.8	-0.9	0.8
Standing height	0.5	5.3	11.6	-2.9	-2.3	2.4	-0.5	-2.4	3.4
Medication: Amlodipine	0.5	0.6	3.5	0.5	-0.5	-0.6	-1.9	-0.2	0.1
Pulse wave peak to peak time	0.5	0.6	1.3	-0.6	-1.1	-1.1	-0.7	-0.9	0.4
Medication: Ibuprofen	0.5	0.6	1.3	1.1	0.8	-0.5	0.3	1.0	-1.1
Medication: Omeprazole	0.5	0.5	1.5	0.5	1.2	0.2	0.2	1.1	-0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.8	0.5	1.3	-1.1	-0.6	0.3	-0.5
Number of full sisters	0.5	0.6	2.4	0.3	1.1	0.4	-1.6	-0.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	0.8	-0.6	-1.0	-0.2	1.2	-0.9
Ever taken oral contraceptive pill	0.5	0.6	2.8	0.8	-0.2	1.7	0.5	-0.4	-0.5
Alcohol drinker status: Never	0.5	0.6	3.2	0.2	0.2	-0.4	-1.8	0.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.2	0.6	1.5	-0.2	-0.2	0.9	-1.0
Arm predicted mass (left)	0.5	2.3	4.3	1.6	-0.5	-1.8	-1.6	2.1	-1.8
Schizophrenia (2018)	0.4	0.9	2.2	-1.0	-1.0	0.6	-0.7	-1.5	1.1
Blood Platelet Count	0.4	4.7	22.8	1.2	-1.2	-2.5	-4.8	-1.0	-0.6
Blood White Count	0.4	2.7	12.7	0.9	1.3	-3.6	-0.2	1.6	-1.2
Height	0.4	8.4	18.6	-4.3	-2.1	3.1	1.2	-2.6	4.2
Chronotype (morning person)	0.4	1.0	4.0	0.1	-1.5	-2.0	0.0	-0.8	0.1
Hearing difficulty/problems: Yes	0.4	0.6	2.5	0.5	-0.2	-1.6	-0.6	-0.9	-0.2
Supplements: Glucosamine	0.4	0.6	1.7	0.9	-0.1	-1.0	0.2	1.3	-0.7
Number of incorrect matches in round	0.4	0.7	2.3	0.6	-1.3	-0.2	1.5	-0.3	-0.7
Mouth/teeth dental problems	0.4	0.6	2.0	0.3	1.2	0.3	1.4	0.5	-0.7
Impedance of arm (right)	0.4	1.8	4.4	-2.1	0.4	1.5	0.7	-1.5	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.2	1.0	1.1	-0.9	0.1	0.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	1.2	0.8	-0.8	0.1	0.6	-0.8
Depression (self-reported)	0.4	0.5	2.7	-0.5	-0.5	-0.2	1.6	0.2	0.4
Lung cancer (father)	0.4	0.5	2.4	0.3	-0.8	0.4	0.1	-1.6	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.2	-1.8	-0.4	1.7	0.1	-0.4	1.4
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	0.3	1.0	1.2	0.5	0.8	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.5	-1.2	0.1	-0.3	0.4	-1.0	1.0
Birth weight	0.4	0.8	3.7	-0.2	0.4	0.1	1.9	1.2	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	3.0	-0.5	0.4	0.1	1.7	0.3	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.5	0.5	-0.0	-1.2	-0.5	0.6	-0.7
Illnesses of father: Heart disease	0.4	0.6	3.5	0.4	-0.6	-0.4	-1.9	-0.1	-0.2
Smoking status: Previous	0.4	0.6	1.4	0.6	1.0	1.2	-0.3	0.8	-0.8
Asthma (self-reported)	0.4	0.8	4.7	0.4	0.1	-2.2	-0.7	0.4	-0.4
Miserableness	0.4	0.6	2.5	1.1	0.6	0.3	-1.6	-0.1	-0.4
Wears glasses or contact lenses	0.4	0.4	1.8	-1.3	-0.1	0.3	0.7	-0.1	0.9
Medication: Lisinopril	0.4	0.5	2.8	-0.0	-0.3	-1.7	0.8	0.1	0.2
Ever smoked	0.4	0.7	1.2	1.0	0.6	-0.5	-1.1	0.9	-1.0
Arm fat-free mass (left)	0.4	2.2	3.7	1.6	-0.6	-1.8	-1.5	1.9	-1.7
Age started oral contraceptive pill	0.4	0.5	1.6	-0.6	-0.8	0.2	-0.3	-1.2	0.8
Commuting to job workplace: Cycle	0.4	0.4	0.9	-0.8	-0.0	-0.7	0.9	-0.6	1.0
Myopia	0.4	0.6	1.3	-1.1	-0.7	1.0	0.1	-0.9	0.9
Impedance of whole body	0.4	2.1	5.7	-1.6	-0.4	1.4	-0.1	-2.4	2.1
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.9	0.5	1.0	1.1	-0.1	0.8
Crohns Disease (2012)	0.3	0.5	1.9	0.4	-0.3	-1.4	-0.0	0.7	-0.8
Blood Eosinophil Count	0.3	2.0	12.8	-0.6	0.3	-3.6	-0.8	-0.2	-0.1
Medication for hormone replacement therapy	0.3	0.3	1.4	0.0	1.2	0.3	0.7	0.3	-0.5
Impedance of leg (right)	0.3	1.6	5.9	-0.5	-1.1	0.6	-0.9	-2.4	1.6
Leg fat-free mass (left)	0.3	1.7	6.1	0.9	0.4	-0.9	-0.5	2.5	-1.8
Townsend deprivation index at recruitment	0.3	0.4	1.3	-0.5	-0.2	-0.5	-1.1	-0.9	0.6
Fed-up feelings	0.3	0.5	1.4	1.2	0.8	0.2	-0.2	0.5	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	1.1	-0.4	-1.0	-0.3	-0.4	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.9	-0.5	0.6	-0.2	-2.0	0.2	0.2
Multivitamins +/- minerals	0.3	0.4	0.9	-0.8	0.4	1.0	0.9	-0.0	0.7
Sitting height	0.3	1.8	5.3	-1.8	-0.6	2.3	0.4	-0.8	1.7
Impedance of leg (left)	0.3	1.5	5.7	-0.2	-1.1	-0.1	-1.2	-2.4	1.4
Leg predicted mass (left)	0.3	1.6	6.2	0.9	0.3	-0.9	-0.6	2.5	-1.8
Past tobacco smoking	0.3	0.5	0.8	-0.7	-0.6	-0.5	0.9	-0.8	0.9
Alcohol usually taken with meals	0.3	0.4	1.9	-0.7	-0.3	0.4	1.4	0.2	0.5
Heart attack	0.3	0.4	2.2	0.3	-0.3	0.1	-1.5	-0.0	0.1
Allergy	0.3	0.7	3.0	0.5	-0.8	1.1	1.7	0.1	-0.3
Father’s age at death	0.3	0.4	1.2	-0.5	0.5	1.1	1.0	0.5	0.2
Number of live births	0.3	0.5	1.5	-0.7	-1.2	-0.5	-0.2	-0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.8	-1.7	-0.4	1.7	-0.3	0.0	1.0
Exposure to tobacco smoke at home	0.3	0.3	1.1	-0.1	-0.5	-0.2	-1.1	-0.7	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	1.1	0.4	-1.0	0.2	0.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.8	-0.5	0.2	-0.2	1.3	0.5	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	-0.2	-0.8	-0.6	0.1	-1.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.4	0.2	0.4	0.2	-0.7	1.2	-0.8
Medication: Allopurinol	0.3	0.3	0.9	-0.9	-0.6	0.7	0.1	0.2	0.8
Suffer from ‘nerves’	0.3	0.5	1.4	1.2	0.1	-0.6	1.2	-0.6	-0.4
Chest pain or discomfort	0.3	0.5	2.2	0.3	0.5	-0.1	-0.1	1.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.7	-0.3	0.4	-0.2	-0.1	1.3	-0.4
Leg fat-free mass (right)	0.3	1.4	5.2	0.7	0.4	-0.9	-0.5	2.3	-1.6
Average weekly red wine intake	0.3	0.5	1.9	0.0	-1.4	0.5	-1.0	-0.5	-0.0
Leg predicted mass (right)	0.3	1.4	5.6	0.7	0.4	-0.9	-0.4	2.4	-1.6
Financial situation satisfaction	0.3	0.3	0.9	0.9	-0.6	-0.5	-0.2	0.2	-0.8
Commuting to job workplace: Public transport	0.3	0.4	2.0	-0.5	0.8	0.0	0.2	1.4	0.3
High cholesterol (Self-reported)	0.3	0.6	2.9	0.2	-1.7	-0.8	0.2	-0.4	0.3
Medication: Atorvastatin	0.3	0.4	1.2	0.4	1.1	0.3	-0.9	0.3	-0.6
Basal metabolic rate	0.3	1.8	5.5	1.2	-0.1	-1.2	-1.1	2.3	-1.8
Depression (Nagel 2018)	0.2	0.3	1.0	0.4	-1.0	0.2	-0.2	-0.7	0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.5	-0.8	-0.6	-0.4	-0.7	0.6
Crohns Disease (2017)	0.2	0.4	1.7	-0.1	-0.7	-0.4	-1.3	-0.7	0.5
LDL Cholesterol	0.2	0.3	0.8	0.5	0.3	-0.7	-0.9	-0.3	-0.4
Lupus	0.2	0.4	1.4	-0.5	0.4	-0.6	0.1	1.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.1	-0.8	0.8	-0.1	0.1	0.2
Blood Red Count	0.2	1.8	4.5	-0.5	2.1	-0.3	2.0	2.0	-0.0
Allergy or Eczema	0.2	0.6	3.4	-0.2	0.8	-0.5	-1.8	0.0	0.1
Sensitivity / hurt feelings	0.2	0.4	2.0	0.1	0.6	0.7	1.4	0.1	0.1
Relative age of first facial hair	0.2	0.4	1.2	-0.7	-0.6	-0.1	1.1	0.2	0.7
Severe depression (siblings)	0.2	0.3	1.2	0.1	-0.1	0.0	-1.1	0.8	-0.2
Hand grip strength (right)	0.2	0.6	2.4	0.2	-1.6	-0.9	-1.1	0.3	-0.1
Average weekly fortified wine intake	0.2	0.2	0.6	-0.7	0.6	-0.3	0.8	0.1	0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.4	-0.6	-0.7	-0.4	-0.6	-0.3
High blood pressure (mother)	0.2	0.3	1.1	-0.6	0.9	0.2	-0.3	-0.3	1.0
Worrier / anxious feelings	0.2	0.4	1.1	0.4	-0.4	0.8	0.6	-1.1	0.2
Happiness	0.2	0.2	0.7	0.8	-0.7	0.0	0.2	-0.1	-0.5
Illnesses of mother	0.2	0.2	0.7	0.8	-0.0	-0.5	0.0	0.0	-0.8
Tense / ‘highly strung’	0.2	0.3	1.5	0.6	-1.2	0.1	0.0	-0.7	-0.0
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	-0.5	0.3	0.8	1.5	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.6	-0.4	0.9	0.4	0.5	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	0.2	-0.6	0.5	-0.7	-0.5	0.1
Gout (self-reported)	0.2	0.2	0.8	-0.2	-0.4	-0.9	-0.7	-0.3	0.2
Arm fat-free mass (right)	0.2	1.0	1.8	1.1	-0.6	-1.1	-1.3	1.4	-1.1
Comparative body size at age 10	0.2	0.7	1.3	-1.0	-1.0	-0.1	1.1	0.8	0.8
Arm predicted mass (right)	0.2	1.0	1.7	1.0	-0.6	-1.1	-1.1	1.3	-1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.0	-0.3	0.8	0.8	-0.1	0.1
Medication: Aspirin	0.2	0.2	0.8	-0.2	-0.8	-0.9	0.0	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.6	-0.3	0.3	-1.0	0.5	-0.3
Medication: Aspirin	0.2	0.2	0.9	-0.1	-0.6	-1.0	-0.3	0.4	0.2
Medication: Gliclazide	0.2	0.3	0.5	0.7	0.3	-0.1	-0.5	0.7	-0.7
Whole body water mass	0.2	0.9	2.7	0.7	-0.6	-0.9	-1.0	1.6	-1.1
Supplements: Calcium	0.2	0.3	1.1	0.2	0.4	0.2	-0.6	1.0	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.5	0.1	-0.5	0.3	-1.2	0.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.9	0.3	-0.1	0.4	-0.6	0.6
Heart disease (siblings)	0.2	0.3	0.8	0.3	-0.9	-0.5	-0.8	0.0	-0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.9	0.4	-0.2	0.1	-0.2	-0.9	0.1
Worry (Nagel 2018)	0.1	0.3	0.9	0.9	-0.2	0.4	0.1	-0.9	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.6	0.2	0.2	0.2	-0.5	0.8
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	0.5	-0.7	-0.6	0.1	-0.1	-0.3
Primary Biliary Cirrhosis	0.1	0.2	1.4	0.1	0.1	0.1	1.2	0.0	0.1
Waist Hip Ratio (WHR)	0.1	0.5	1.4	0.8	1.1	1.2	0.3	-0.0	-0.6
Lung FVC	0.1	0.7	2.5	-0.3	0.7	1.1	0.5	1.6	-0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.9	1.0	-0.2	0.2	-0.0	-0.2	-0.6
Vitamin and mineral supplements	0.1	0.1	0.2	-0.3	-0.1	0.5	-0.4	-0.5	0.1
Relative age voice broke	0.1	0.2	0.6	-0.4	-0.3	0.5	0.2	0.8	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.9	-0.3	1.4	0.1	0.4	-0.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	0.8	-0.2	-0.2	0.6	-0.3	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.6	0.3	-0.3	-0.8	-0.7	0.1	-0.1
Had menopause	0.1	0.2	0.7	-0.1	-0.6	0.1	0.8	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.3	0.6	1.1	-0.4	0.0	-0.5	-0.5
Trunk fat-free mass	0.1	0.5	1.4	0.2	-1.2	-0.4	-0.9	1.0	-0.3
Trunk predicted mass	0.1	0.5	1.4	0.2	-1.2	-0.4	-0.9	1.0	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.5	0.8	0.5	-0.5	0.8	-0.1
Loud music exposure frequency	0.1	0.2	0.3	0.5	-0.5	-0.3	-0.6	0.0	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.2	0.8	0.3	0.8	-0.2	-0.1
Medication: Blood pressure	0.1	0.2	0.5	0.6	-0.7	-0.4	-0.2	0.5	-0.3
Whole body fat-free mass	0.1	0.8	2.8	0.6	-0.5	-0.8	-0.9	1.7	-1.0
Mood swings	0.1	0.2	0.5	0.5	0.7	0.7	-0.2	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	-1.1	-0.5	0.2	-0.1	-0.0	0.7
Hair Pigment	0.0	1.2	6.6	0.1	2.6	-1.1	0.8	0.1	-0.2
Tanning	0.0	0.6	1.9	-0.0	1.0	0.8	-1.4	0.7	-0.4

Hub : Genes

TSKU

Models

Trait associations