Hub : Genes

TSPAN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1160	0.0400	3.0e-05	0.060	0.055	0.043	0.052	0.047	7.7e-08	2.8e-07	5.1e-06	6.1e-07	1.9e-06
2	GTEx	Adipose Visceral Omentum	0.2350	0.0870	2.1e-03	-0.005	NA	-0.005	NA	-0.005	9.3e-01	NA	8.7e-01	NA	9.4e-01
3	GTEx	Brain Cerebellar Hemisphere	0.4120	0.0900	6.5e-05	0.288	NA	0.030	NA	0.313	4.3e-08	NA	5.9e-02	NA	9.0e-09
4	GTEx	Brain Cerebellum	0.6590	0.0660	3.5e-12	0.483	NA	0.545	NA	0.550	3.3e-16	NA	5.0e-19	NA	3.0e-19
5	GTEx	Heart Atrial Appendage	0.2030	0.0780	5.6e-04	0.105	NA	0.022	NA	0.051	2.0e-05	NA	3.4e-02	NA	2.6e-03
6	GTEx	Heart Left Ventricle	0.1301	0.0466	2.7e-04	0.090	NA	0.066	NA	0.074	1.6e-05	NA	2.1e-04	NA	8.9e-05
7	NTR	Blood	0.0326	0.0107	2.1e-05	0.008	0.018	0.011	0.018	0.011	1.2e-03	1.5e-06	1.5e-04	9.6e-07	1.3e-04
8	YFS	Blood	0.0381	0.0123	1.2e-05	0.021	0.017	0.017	0.021	0.021	1.8e-07	2.5e-06	1.5e-06	1.6e-07	1.0e-07
9	TCGA	Breast Invasive Carcinoma	0.0252	0.0146	7.0e-03	0.009	0.015	0.008	NA	0.014	4.7e-03	3.1e-04	7.5e-03	NA	5.6e-04
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0448	0.0254	8.3e-04	0.044	0.035	0.032	NA	0.042	1.1e-05	6.8e-05	1.6e-04	NA	1.6e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	2.1	3.3	14.0	1.6	3.4	1.5	1.3	0.5	0.1	-0.0	-0.7	3.7	-0.1
Bipolar Disorder or Schizophrenia	1.7	4.3	13.4	1.7	3.5	2.4	2.3	0.6	-0.2	1.5	0.3	3.7	-0.6
Depressed Affect (Nagel 2018)	1.4	3.0	8.8	-2.7	-2.6	-1.8	-1.5	-0.8	-0.3	-0.6	-0.1	-3.0	0.3
Depression (Nagel 2018)	2.5	3.7	15.3	-3.9	-2.0	-1.0	-0.9	-0.7	-1.2	-0.0	-0.8	-3.6	-0.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.6	-0.9	-0.5	-0.5	-0.6	-1.4	-1.6	-0.7	1.3	-0.3	1.6
Neuroticism (Nagel 2018)	0.9	2.2	7.5	-2.7	-2.3	-0.8	-0.6	-0.1	-0.8	0.1	-1.2	-2.4	-0.1
Schizophrenia (2018)	0.9	1.9	3.9	0.8	1.8	2.0	1.9	0.3	-0.3	1.9	1.1	1.7	-0.6
Schizophrenia vs Biploar Disorder	0.8	1.1	5.4	-1.6	-0.5	0.3	0.5	1.0	-0.0	-0.2	-2.3	-1.2	-0.4
Worry (Nagel 2018)	0.6	1.3	3.2	-0.7	-0.5	1.6	1.8	0.4	-0.9	1.7	-1.3	-0.6	-0.3
Alzheimer’s Disease (in mother)	1.1	1.3	4.9	0.1	2.2	-0.7	-0.7	-1.0	-0.3	-1.9	0.8	1.3	0.8
Alzheimer’s Disease (in father)	1.5	1.6	6.9	-0.9	-0.9	-2.3	-2.6	0.1	0.2	-0.9	0.1	-1.1	-0.5
Alzheimer’s Disease (including proxy)	1.0	1.4	3.9	-0.3	1.2	-1.8	-2.0	-1.1	0.0	-1.5	1.1	0.3	0.8
Crohns Disease (2017)	0.7	1.6	4.7	-1.1	-0.8	-2.0	-2.1	-0.1	-0.7	-0.9	-2.2	-0.3	0.3
Irritable Bowel Disease (IBD)	0.8	2.0	5.7	-1.4	-0.3	-2.1	-2.0	-0.6	-0.5	-1.5	-2.4	-0.3	0.7
Ulcerative Colitis (UC)	0.3	0.6	2.0	-0.6	-0.2	-1.2	-1.0	-0.4	-0.1	-1.1	-1.4	-0.3	0.2
Major Depression (MDD)	1.4	1.8	4.3	1.4	0.6	0.9	0.8	1.3	2.0	1.3	-1.2	0.6	-2.1
Reaction Time	1.4	2.7	5.7	-1.8	1.3	-1.8	-1.7	2.4	-1.1	-1.6	-2.3	-0.8	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	0.6	-0.8	0.5	0.1	-0.5	-1.1	1.0	0.6	0.4	0.0
Breast Cancer	0.4	1.0	2.6	0.2	-0.7	-1.4	-1.4	0.3	0.5	-1.1	0.1	-1.2	-1.6
Ovarian Cancer	0.5	0.7	2.3	0.3	0.7	-1.2	-1.3	0.4	0.1	-1.5	0.4	0.8	0.3
Prostate Cancer	1.5	2.1	9.6	-0.5	3.1	-1.3	-0.9	1.1	0.6	-1.3	-0.6	2.0	-0.9
Age at First Birth	1.2	1.8	5.1	1.9	0.7	0.9	0.5	2.2	1.1	0.9	-0.6	0.8	-2.2
Bipolar Disorder (2011)	2.3	2.2	7.7	2.8	1.0	0.8	0.6	1.0	1.2	1.8	0.8	2.0	-1.5
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.7	-0.7	-0.1	-0.1	-0.1	0.3	-0.3	0.7	-0.0	-0.7
Coronary Artery Disease (CAD)	1.8	2.1	6.6	0.2	1.7	1.7	1.9	1.3	0.8	1.5	-2.6	0.9	0.3
Crohns Disease (2012)	0.4	0.6	1.7	-0.2	-1.2	-0.1	-0.3	-1.0	-0.7	0.4	-0.2	0.9	1.3
Mean Putamen Volume	0.4	0.5	1.3	-0.9	0.8	0.3	0.4	0.1	-0.0	-0.7	-1.1	0.8	0.7
Fasting Glucose	0.4	0.5	1.3	0.2	1.1	-0.4	-0.5	-0.2	-1.2	-1.1	0.9	-0.2	-0.1
HbA1C	0.6	0.7	3.3	0.3	-1.8	0.7	0.8	-0.6	0.2	0.8	0.4	0.8	0.7
HDL Cholesterol	0.1	0.2	1.3	0.0	1.1	0.1	0.4	0.5	0.4	0.5	0.4	0.3	-0.1
LDL Cholesterol	0.5	0.7	1.9	1.4	-0.4	0.6	0.8	0.8	1.4	0.7	-0.5	-0.7	-0.6
Lupus	1.4	2.1	11.6	1.5	-0.8	-0.7	-0.7	0.7	1.3	0.9	3.4	0.9	-1.5
Neuroticism (2016)	2.4	3.5	14.9	-3.9	-0.7	-1.0	-0.8	0.4	-1.1	-1.4	-2.9	-2.0	1.5
Primary Biliary Cirrhosis	0.2	0.3	0.7	-0.1	-0.6	-0.7	-0.6	-0.2	0.0	-0.2	-0.8	-0.8	0.5
Rheumatoid Arthritis	0.7	0.9	2.3	-0.6	-0.5	-1.5	-1.2	0.0	0.0	-1.2	-1.5	0.0	0.9
Schizophrenia (2014)	1.1	2.3	8.5	0.7	2.9	1.9	1.8	0.7	-0.1	1.0	-0.3	2.3	-0.7
Triglycerides	0.5	0.7	2.6	0.9	-0.6	-0.7	-0.8	0.8	1.6	-0.3	0.4	0.2	-1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.1	-1.3	-0.1	-0.6	-0.7	0.1	-0.1	0.4	-1.4	-1.8	0.6
Ulcerative Colitis	0.3	0.4	2.4	-0.3	1.1	-0.0	0.3	-0.0	0.4	0.3	-1.6	0.1	0.1
Blood Eosinophil Count	0.3	2.4	10.4	-0.7	0.8	-0.4	-0.4	3.2	1.5	0.1	-2.8	-1.0	-1.1
Blood Platelet Count	0.1	1.7	5.3	-1.8	-1.3	0.1	0.6	-1.3	0.6	-0.2	-0.9	-2.3	2.0
Blood Red Count	0.3	2.5	6.8	0.0	1.0	-2.6	-2.4	2.0	1.5	-0.4	0.9	-0.7	-1.9
Blood White Count	0.7	5.5	15.1	-0.4	-1.3	3.7	3.9	1.4	1.5	3.2	-1.6	-1.9	-1.9
Heel T-Score	0.3	2.7	5.1	0.3	0.2	2.1	2.2	2.0	1.7	1.8	-1.9	-1.8	-1.0
BMI	1.5	8.6	24.5	-2.9	-0.6	-4.8	-4.7	-0.9	-0.6	-5.0	0.6	-1.9	1.3
Height	0.2	4.4	14.3	0.1	-3.1	1.1	0.7	1.6	0.8	0.3	-3.6	-3.8	-1.3
Waist Hip Ratio (WHR)	0.5	2.3	7.9	-1.6	0.5	-2.4	-1.9	-0.1	-1.2	-2.8	0.3	0.3	1.3
Systolic Blood Pressure	0.7	3.6	19.6	-2.3	4.4	0.8	1.1	1.6	-1.5	1.2	-0.3	-1.6	0.6
Smoking Status	0.8	2.0	5.1	0.1	-1.5	-2.3	-2.2	-0.6	1.7	-1.3	-0.0	-1.6	0.4
Allergy or Eczema	0.6	1.6	4.4	-1.9	-1.5	0.1	-0.2	1.3	0.2	0.9	-1.8	-2.1	-0.1
Cardiovascular Disease	0.5	1.8	10.7	-1.4	3.3	-0.0	0.2	-0.2	-0.2	0.3	1.5	-0.6	1.4
Hypothyroidism (self reported)	0.4	1.0	5.2	0.1	-2.3	-0.2	-0.3	-0.9	0.5	-0.2	0.1	1.1	1.4
Respiratory disease	0.7	1.6	4.5	-2.0	-0.8	0.4	0.2	-0.3	-1.1	-1.3	-1.3	-2.1	1.6
Type 2 Diabetes (T2D) (2018)	1.0	1.9	7.1	-2.7	0.3	-1.2	-1.0	-1.4	-0.9	-1.9	-0.8	-0.2	1.5
Lung FEV1/FVC ratio	0.9	4.6	17.9	-0.7	-1.2	-4.2	-4.0	1.8	0.9	-1.0	0.6	-0.7	-2.1
Lung FVC	1.8	9.2	32.4	-3.5	-0.8	1.2	0.9	-3.4	-5.7	-2.8	-1.4	0.8	4.7
Neuroticism	0.9	2.1	7.6	-2.8	-1.4	0.0	0.3	-0.1	-1.7	0.3	-1.7	-2.5	0.2
Chronotype (morning person)	1.9	4.5	14.0	-1.1	-0.3	2.2	2.1	-3.7	-3.0	-0.9	0.4	0.4	3.2
Hair Pigment	0.1	1.8	5.2	0.3	-0.6	-2.0	-1.8	-0.3	-0.3	-2.3	1.5	1.4	0.4
Tanning	0.2	2.9	7.0	0.8	0.1	-1.5	-1.4	1.9	1.3	-2.0	-1.6	-2.6	-2.2
Hand grip strength (left)	0.3	0.8	3.2	-1.1	0.6	0.9	1.1	0.4	-0.8	-0.1	-0.6	-1.8	0.2
Number of treatments/medications taken	0.2	0.4	2.4	-0.1	-0.2	0.7	0.5	0.5	0.5	0.4	-0.2	-1.6	-0.2
Average weekly spirits intake	3.6	4.5	11.9	-3.5	-1.3	-1.6	-1.5	-0.7	-2.4	-3.3	-0.9	-1.9	2.2
Sensitivity / hurt feelings	0.8	1.4	6.3	-1.1	-0.5	-1.0	-0.9	1.1	-0.6	-1.0	-2.5	-1.2	-0.9
Frequency of depressed mood in last 2 weeks	1.9	2.6	6.5	-2.5	-2.4	1.3	1.4	0.5	0.0	1.3	-1.4	-2.5	-0.7
Hearing difficulty/problems: Yes	0.5	0.7	2.6	-1.1	-0.9	0.8	0.6	-1.6	-0.8	-0.2	0.6	-0.1	0.7
Relative age of first facial hair	0.4	0.8	3.5	-0.5	1.9	-0.2	-0.1	0.1	-0.4	-0.3	-1.2	1.6	0.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.4	1.0	-0.3	1.6	1.5	-0.1	0.4	1.4	1.2	0.1	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.7	-0.5	-1.6	-0.0	-0.3	-1.0	-0.1	0.2	0.8	-1.1	0.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	-0.9	-0.4	-0.3	-0.4	-1.0	-1.3	-1.6	0.1	-0.5	0.6
Systolic blood pressure, automated reading	0.6	1.7	6.6	-2.6	1.9	-0.1	-0.1	0.3	-1.8	-0.3	-0.8	-1.4	1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	-1.2	0.3	-1.5	-1.4	0.1	0.3	-1.1	-1.2	-0.5	0.0
Angina	0.6	0.8	4.0	-2.0	-1.6	0.2	0.2	-0.0	-0.1	-0.4	-0.3	0.0	1.1
Medication for hormone replacement therapy	2.1	2.3	6.1	0.2	-0.4	2.5	2.3	-1.7	-1.2	1.8	1.5	0.1	1.4
Vitamin and mineral supplements	0.3	0.4	1.3	-0.2	0.2	0.3	0.1	-1.1	-0.9	-0.4	0.8	-0.3	1.1
Supplements: Zinc	0.8	0.9	2.3	-1.4	0.9	0.9	1.2	-0.5	-0.9	-0.5	-0.7	-0.2	1.5
Medication: Co-codamol	2.4	2.8	7.7	-0.6	-1.3	1.4	1.1	-2.8	-2.5	0.2	2.1	-1.1	1.6
Medication: Metformin	1.7	2.5	9.4	-3.1	1.3	-1.3	-1.5	-0.9	-1.5	-2.0	-0.5	-0.4	1.4
Diabetes (father)	1.0	1.2	4.5	-0.6	-0.3	0.6	0.4	-2.1	-1.6	-0.9	-0.1	-0.5	1.8
Diabetes (mother)	1.0	1.2	4.0	-2.0	-0.5	-0.6	-0.3	-0.3	-1.1	-0.8	-1.8	-1.3	0.8
Severe depression (siblings)	1.1	1.2	5.1	0.4	1.0	1.1	1.1	0.7	0.6	0.4	-2.3	1.6	0.1
Pack years adult smoking proportion	0.1	0.2	0.9	-0.1	-0.5	0.3	0.7	-0.9	0.2	-0.0	0.1	0.2	0.4
Impedance of leg (right)	0.5	2.4	6.2	1.8	-1.4	1.5	1.8	1.1	0.9	1.0	-2.5	-0.8	-1.9
Leg fat-free mass (left)	1.0	5.2	11.8	-2.8	-0.7	-3.1	-3.4	-0.5	-0.7	-3.3	1.1	-2.8	1.0
Trunk fat percentage	1.6	6.2	15.9	-3.0	-0.1	-3.5	-3.5	-0.5	-1.8	-4.0	-0.9	-2.5	1.5
Hand grip strength (right)	0.3	0.7	2.4	-1.0	0.1	0.9	1.0	0.1	-1.3	0.1	-0.6	-1.6	-0.1
Townsend deprivation index at recruitment	0.6	0.9	2.2	-1.5	-0.7	1.3	1.2	-0.9	-0.7	0.1	0.5	-0.2	1.4
Current tobacco smoking	1.2	2.0	5.5	-0.5	-0.7	-2.4	-2.1	-1.8	0.4	-1.7	0.8	-1.1	0.9
Average weekly fortified wine intake	1.1	1.3	4.0	-1.0	-0.4	0.1	0.2	2.0	0.4	0.9	-1.7	-1.7	-1.2
Maternal smoking around birth	0.2	0.3	1.5	-1.2	-0.1	-0.1	0.2	-0.2	0.7	0.1	-0.0	-0.4	0.9
Fed-up feelings	1.2	2.2	7.4	-2.7	-2.3	-0.8	-0.5	-0.4	-0.4	-0.1	-0.5	-2.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	13.0	-3.6	-2.3	-1.3	-1.2	-0.8	-1.0	-1.2	-1.5	-2.9	0.5
Relative age voice broke	0.2	0.3	1.0	-0.0	0.6	0.2	0.4	0.5	0.3	0.9	-0.3	0.3	-1.0
Taking other prescription medications	0.3	0.5	1.1	0.2	-0.8	0.5	0.4	0.9	0.9	1.0	0.3	-0.8	-0.4
Age when periods started (menarche)	0.7	1.7	5.5	0.5	0.6	0.1	0.2	2.4	2.0	1.3	-0.9	-0.7	-1.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.9	0.3	-0.8	-1.3	-1.4	1.4	1.3	-0.8	-1.1	-0.8	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.9	-0.1	1.3	1.2	1.4	0.7	-0.4	0.6	-0.9	-1.2	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	3.8	-1.5	1.3	-0.5	-0.2	-1.4	-1.1	-0.3	-0.1	-0.4	1.9
Qualifications: CSEs or equivalent	0.5	0.7	2.0	-0.4	0.3	0.9	1.3	-0.7	-0.4	0.5	1.4	0.6	0.9
Serious illness, injury or assault to yourself	1.5	1.8	5.1	-2.2	-2.1	0.9	0.9	-0.5	0.1	0.9	-0.2	-2.2	0.8
High blood pressure	0.6	1.6	9.5	-1.8	3.1	-0.3	-0.1	0.5	-0.6	-0.5	0.4	-0.8	1.2
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.5	-2.0	-0.7	0.1	-0.0	1.1	0.1	1.1	-1.5	-2.1	0.1
Multivitamins +/- minerals	0.5	0.6	2.1	0.9	-0.1	0.4	0.6	1.0	0.7	1.4	-0.4	-0.4	-1.0
Stomach or abdominal pain in last month	1.0	1.3	7.4	-1.4	0.0	1.0	1.2	0.4	-0.1	0.8	0.1	-2.7	0.2
Supplements: Glucosamine	0.5	0.7	2.0	0.5	0.3	1.3	1.2	0.6	1.4	0.8	0.1	0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	5.4	1.1	0.4	-0.7	-0.8	1.4	1.4	-0.7	-1.2	-1.3	-2.3
Medication: Atenolol	0.3	0.4	1.3	-0.8	-0.1	0.3	0.7	1.2	-0.8	0.8	-0.1	-0.2	-0.4
Medication: Levothyroxine sodium	0.4	0.8	3.0	0.8	-0.7	-1.1	-0.8	-0.4	0.8	-0.7	0.2	1.7	0.6
Sitting height	0.7	5.1	22.1	-2.9	-2.8	1.4	1.1	-1.4	-2.2	0.6	-0.6	-4.7	1.5
Chronic bronchitis/emphysema (father)	2.5	2.9	8.2	-0.8	-1.3	1.2	1.3	-2.9	-1.9	1.6	2.0	-1.7	1.5
High blood pressure (mother)	1.6	2.3	8.5	-2.9	0.5	0.6	0.6	-0.6	-2.1	-1.4	-0.3	-1.2	2.2
Body mass index (BMI)	2.0	8.7	24.7	-3.0	-0.2	-4.8	-4.8	-0.4	-0.6	-5.0	0.9	-1.9	1.0
Impedance of leg (left)	0.6	3.1	5.7	2.1	-1.1	2.0	2.3	1.3	1.0	1.7	-2.4	-0.8	-2.1
Leg predicted mass (left)	1.0	5.2	12.3	-2.8	-0.6	-3.2	-3.5	-0.4	-0.7	-3.4	1.1	-2.8	1.0
Trunk fat mass	1.8	7.9	20.9	-3.1	-0.5	-4.1	-4.2	-0.1	-1.3	-4.6	-0.7	-3.2	1.0
Waist circumference	2.3	8.6	24.6	-2.6	-0.4	-5.0	-5.0	-0.4	-0.3	-5.0	1.2	-1.7	0.8
Number of incorrect matches in round	0.4	0.6	1.7	0.8	-1.3	0.4	0.3	0.7	0.2	1.2	0.8	-0.6	-0.9
Past tobacco smoking	0.6	1.0	4.0	-1.7	0.4	-0.4	-0.3	-0.2	-2.0	-0.2	1.5	-0.6	0.4
Alcohol usually taken with meals	3.8	6.1	12.0	2.6	2.0	3.5	3.4	1.9	1.6	3.0	-0.2	2.1	-2.5
Nervous feelings	0.8	1.4	3.2	-0.1	-0.1	1.7	1.7	1.6	0.2	1.3	-1.8	-0.2	-0.9
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	9.4	-2.5	-2.3	-0.1	-0.0	-2.4	-2.0	-0.8	-0.4	-3.1	1.7
Hearing difficulty/problems with background noise	1.7	2.7	6.6	-2.4	-0.6	0.1	0.4	-2.6	-2.4	-0.3	1.1	-0.6	2.5
Hair/balding pattern: Pattern 2	0.7	0.8	5.4	-0.7	1.0	0.2	0.3	0.5	-0.6	-0.9	-2.3	0.2	0.1
Had menopause	0.5	0.6	1.3	-1.1	-1.1	0.4	0.1	-1.0	-0.6	-0.8	-1.1	-0.1	0.3
Had other major operations	1.4	1.7	6.5	1.0	-0.7	1.5	1.3	-2.6	-0.6	0.3	1.7	0.1	1.2
Forced vital capacity (FVC)	1.7	6.4	17.7	-3.7	-1.5	1.2	1.0	-1.8	-4.2	-2.3	-2.1	-2.7	2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	5.6	-0.4	1.2	2.1	2.4	0.9	-0.5	1.7	-1.5	-1.7	0.7
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	5.2	-1.4	-1.1	-1.2	-1.3	-1.7	-2.3	-1.6	0.7	-1.7	1.1
Qualifications: None of the above	2.6	5.6	13.0	-2.4	-1.9	-3.6	-3.5	-1.1	0.3	-2.7	-1.1	-3.3	0.7
Financial difficulties in last 2 years	0.6	0.8	2.6	-0.7	-0.9	0.6	0.7	-1.3	-0.2	1.1	0.6	0.2	1.6
Mouth/teeth dental problems	0.8	1.3	8.1	1.1	2.8	-0.0	-0.1	-0.1	-0.5	0.3	0.5	1.5	0.5
Heart attack	0.2	0.3	1.6	0.3	0.2	-0.1	0.2	0.6	0.5	0.4	-0.7	1.3	-0.1
Allergy	0.9	2.1	7.4	2.6	0.9	1.1	1.1	-0.5	0.5	0.8	1.1	2.7	-0.9
Pain all over the body in last month	1.3	1.4	5.5	-0.6	0.8	-2.4	-2.2	0.9	1.0	-0.8	0.4	-0.0	-0.1
Diabetes (self-reported)	1.1	1.7	4.0	-1.7	1.6	-2.0	-1.8	0.1	0.4	-1.8	-0.6	0.6	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	3.2	-0.8	1.8	0.6	0.6	0.7	-0.2	0.5	-0.5	-0.6	-0.2
Medication: Ramipril	1.3	1.6	3.0	1.5	1.0	-1.5	-1.5	1.3	1.3	-0.6	1.0	1.7	-0.9
Medication: Simvastatin	1.0	1.4	4.6	0.7	0.2	0.1	0.1	2.1	1.8	0.9	-1.7	0.9	-1.3
Fluid intelligence score	0.3	0.6	2.1	1.5	-0.6	-0.3	-0.4	0.3	-0.6	0.2	0.1	1.4	-1.0
Illnesses of siblings	2.7	3.8	14.7	3.8	2.3	1.3	1.4	0.5	1.4	1.4	1.4	2.6	-1.1
Neuroticism score	0.5	1.0	3.8	-1.2	-1.4	0.4	0.5	0.1	-0.7	0.7	-2.0	-1.0	-0.1
Weight	1.6	7.9	20.6	-3.0	-1.2	-4.1	-4.3	0.0	-0.4	-4.5	0.2	-3.4	0.5
Impedance of arm (right)	1.0	4.8	14.7	0.7	0.8	3.8	3.8	-0.3	-1.6	3.6	-1.5	0.3	0.4
Arm fat percentage (right)	1.6	6.5	15.6	-3.3	0.2	-3.6	-3.7	-0.5	-1.9	-3.9	-0.2	-2.3	1.5
Trunk fat-free mass	0.9	5.2	13.0	-1.6	-1.6	-3.2	-3.6	1.1	1.1	-3.3	0.3	-3.0	-1.0
Hip circumference	1.2	5.2	15.5	-2.0	-0.9	-3.6	-3.9	0.2	0.0	-3.7	0.8	-2.2	0.0
Time employed in main current job	0.4	0.4	1.7	-1.0	1.3	0.4	0.5	0.0	-0.7	0.7	-0.0	0.3	0.2
Alcohol intake versus 10 years previously	0.8	1.2	2.8	0.9	-1.7	1.0	0.7	-0.6	0.6	1.5	1.6	-1.0	0.0
Father’s age at death	0.9	1.2	3.6	1.6	1.3	0.7	0.4	-0.2	-0.3	1.5	0.9	1.9	0.4
Worrier / anxious feelings	0.6	1.1	3.9	0.5	0.2	1.3	1.4	0.6	-0.3	1.2	-2.0	1.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.5	7.5	-2.2	-2.6	2.2	1.8	-2.6	-2.7	1.4	-0.3	-1.7	2.4
Falls in the last year	2.9	4.0	12.4	-3.5	-2.6	-0.4	-0.5	-2.2	-1.5	-1.1	0.9	-2.2	2.4
Hair/balding pattern: Pattern 3	1.7	2.5	6.9	2.6	0.2	-1.5	-1.4	1.3	2.6	-1.2	1.0	0.5	-1.6
Number of live births	0.9	1.2	4.3	0.6	-0.4	1.7	1.9	-0.3	0.1	2.1	0.3	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	14.4	-3.8	-1.1	0.2	0.1	-0.9	-3.5	-2.5	-2.5	-1.8	2.4
Pulse rate	0.8	1.4	5.6	-0.4	-0.3	0.3	0.6	-2.0	-1.3	-1.1	0.4	0.0	2.4
Happiness	3.3	4.0	9.9	-2.9	-1.7	1.6	1.4	-2.0	-3.1	0.8	-0.5	-2.4	2.0
Noisy workplace	4.7	5.8	12.3	-3.4	-1.9	-2.2	-2.3	-2.8	-2.2	-3.5	-0.8	-1.0	2.5
Qualifications: A levels/AS levels or equivalent	1.5	3.4	10.0	1.3	0.2	3.0	2.8	1.6	-0.1	3.2	0.8	1.3	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.7	-0.5	0.6	0.7	0.7	0.8	1.6	0.4	-0.2	-1.0	-0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	3.0	-1.7	-1.2	-0.8	-1.0	-0.2	-0.7	-1.3	-1.2	-0.3	0.4
Asthma	0.8	1.5	4.3	-1.7	0.2	-1.3	-1.3	0.6	-0.4	-2.1	-0.6	-1.9	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	5.8	0.5	-2.4	-0.4	-0.4	-1.3	-0.4	-0.0	1.5	-1.8	0.4
Medication: Cholesterol lowering	0.7	1.1	4.4	-0.2	0.5	-0.8	-0.7	1.1	1.7	-0.6	-0.7	2.1	-0.5
Depression (self-reported)	0.2	0.2	0.6	-0.2	-0.8	0.2	0.0	-0.3	-0.1	0.6	-0.5	-0.5	-0.5
Medication: Lansoprazole	0.3	0.3	1.3	0.3	0.0	0.6	0.6	0.2	0.0	0.8	-1.2	-0.2	-0.3
Prospective memory result	1.4	1.7	8.9	-0.1	1.0	-0.1	0.5	3.0	1.8	0.2	-1.7	-0.7	-0.5
Lung cancer (father)	0.6	0.8	3.3	1.3	-0.2	0.4	0.3	0.6	1.8	-1.0	-0.5	0.7	-0.6
Illnesses of mother	1.1	1.3	3.9	2.0	0.7	0.5	0.3	0.3	1.6	1.9	0.5	0.9	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	13.0	-3.6	-0.6	-0.1	-0.3	-0.8	-3.6	-2.6	-2.0	-1.6	2.2
Pulse wave Arterial Stiffness index	0.6	0.6	2.3	1.2	-0.6	0.6	0.5	-0.9	-0.7	0.6	1.5	-0.4	-0.1
Impedance of arm (left)	1.0	4.6	13.5	0.5	1.2	3.5	3.7	0.0	-1.5	3.1	-2.4	0.6	0.7
Arm fat mass (right)	2.0	8.2	22.0	-3.4	-0.4	-4.3	-4.4	-0.3	-1.2	-4.7	0.1	-2.7	1.2
Trunk predicted mass	0.9	5.4	13.4	-1.7	-1.6	-3.3	-3.7	1.1	1.1	-3.4	0.4	-3.0	-1.0
Standing height	0.2	2.3	13.0	-0.4	-2.0	0.6	0.2	1.2	0.5	-0.1	-1.5	-3.6	-1.2
Length of working week for main job	0.9	1.0	3.3	0.1	-0.4	-1.6	-1.3	0.5	0.7	-1.8	-1.3	0.5	-0.2
Exposure to tobacco smoke at home	0.8	0.9	3.2	-0.8	-0.4	1.4	1.2	0.1	-0.6	1.8	0.1	0.2	1.1
Breastfed as a baby	1.1	1.4	5.7	-0.2	-2.4	-0.4	-0.3	1.1	1.0	1.0	-0.1	-1.4	-1.8
Tense / ‘highly strung’	0.9	1.4	3.8	-0.2	0.5	1.9	2.0	-0.7	-1.7	1.0	-1.1	0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	7.1	-0.8	-1.4	1.8	1.9	-2.7	-1.2	0.7	-0.2	0.2	2.4
Hair/balding pattern: Pattern 4	0.2	0.6	3.6	0.3	0.6	0.3	0.2	0.1	-0.4	1.0	0.6	1.9	-0.4
Birth weight of first child	0.5	0.9	2.8	1.2	-0.9	0.9	0.6	0.7	1.1	0.7	-0.5	-0.1	-1.7
Peak expiratory flow (PEF)	1.1	2.6	8.0	-2.5	-1.3	-0.4	-0.4	0.5	-1.5	-1.6	-2.8	-2.2	0.8
Pulse wave reflection index	0.7	0.8	2.9	1.7	-0.1	0.6	0.4	0.2	-0.5	0.6	1.3	0.1	-1.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.4	0.7	-0.3	0.1	-0.9	-0.1	0.0	-0.5	-0.9	1.0
Loud music exposure frequency	0.8	0.8	3.2	-0.2	0.8	-0.5	-0.5	-1.3	-1.0	-1.8	-0.2	0.3	1.0
Qualifications: O levels/GCSEs or equivalent	3.9	6.3	21.0	1.0	1.5	4.6	4.5	-0.1	-1.1	2.9	-0.3	2.9	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.0	-1.0	0.3	0.3	0.5	-0.3	-0.6	-0.4	0.1	0.4	1.0
Blood clot in the leg (DVT)	1.2	1.6	4.7	0.1	-0.3	-0.9	-1.1	-2.2	-1.5	-1.4	0.9	1.0	1.8
Medication: Paracetamol	1.2	2.0	11.0	-0.9	-1.6	1.1	1.2	-0.3	-1.4	-0.9	-0.2	-3.3	0.1
Headache pain in last month	2.7	4.6	11.7	1.2	-3.4	2.5	2.3	0.8	0.3	2.9	0.0	-3.2	-1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.0	0.3	-2.5	0.8	0.6	-1.9	-1.9	0.0	1.2	-1.5	0.4
Glaucoma (self-reported)	1.0	1.2	3.8	0.1	-0.6	1.2	1.4	-0.8	-0.8	1.2	1.1	-1.9	0.3
Gout (self-reported)	1.3	1.8	5.5	1.9	0.6	0.5	0.5	0.7	1.2	2.4	1.9	0.5	-1.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.8	0.5	-1.0	-1.2	-1.1	-0.4	1.0	-0.8	0.1	1.4	0.8
Medication: Amlodipine	1.4	2.0	13.1	0.5	3.6	0.3	0.3	0.1	-1.0	-0.3	0.3	2.3	0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.4	-2.1	-0.9	-0.8	-0.8	-0.9	-0.8	-1.7	-0.7	-0.9	0.8
Birth weight	0.4	0.8	2.2	-1.0	0.6	0.4	0.0	-0.6	-1.2	-1.2	-1.5	1.1	-0.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	3.5	0.3	-1.9	-0.4	-0.4	-0.5	1.0	-0.1	0.3	0.0	0.2
High blood pressure (siblings)	1.7	2.5	4.9	-2.1	-2.2	-0.7	-1.0	-1.0	-1.6	-2.0	-0.4	-2.2	1.3
Forced vital capacity (FVC), Best measure	1.6	5.7	15.8	-3.6	-0.7	0.7	0.4	-1.6	-4.0	-2.7	-1.8	-2.5	2.7
Body fat percentage	1.7	6.9	18.7	-2.9	-0.3	-3.9	-3.8	-0.3	-1.5	-4.3	-0.7	-2.7	1.3
Leg fat percentage (right)	2.3	8.5	26.3	-2.5	-0.9	-4.7	-4.6	0.1	-0.5	-5.1	-0.5	-2.7	0.4
Arm fat-free mass (right)	1.4	7.2	19.4	-1.8	-1.7	-4.1	-4.3	0.7	0.8	-4.4	0.7	-2.9	-0.6
Exposure to tobacco smoke outside home	1.0	1.3	4.4	-2.1	0.5	-0.7	-0.5	0.3	-0.4	-1.3	-1.6	-1.8	0.5
Comparative body size at age 10	1.0	2.7	8.0	-2.8	-0.6	-0.8	-0.7	-2.2	-1.7	-2.1	0.8	-0.1	2.0
Number of full brothers	0.6	0.8	2.0	-1.2	-0.6	0.6	0.7	-1.1	-0.7	0.3	0.4	-1.4	1.1
Worry too long after embarrassment	0.7	1.2	6.6	-0.7	1.4	0.4	0.3	1.5	0.2	0.1	-2.6	-0.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.1	-0.5	-0.9	0.5	0.4	0.9	0.5	1.1	-1.4	-0.2	-0.4
Wheeze or whistling in the chest in last year	1.6	2.9	11.2	-2.4	-1.9	-0.7	-0.8	-1.7	-1.2	-0.6	0.9	-3.4	1.4
Number of children fathered	1.3	1.4	4.4	-1.5	-1.3	0.2	0.4	1.0	0.3	0.6	-2.0	-2.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.2	-2.0	1.6	0.2	-0.1	-0.3	-1.2	-1.1	-0.6	-0.1	1.3
Age at first live birth	0.5	0.9	3.2	1.8	1.2	0.4	0.1	1.5	0.3	0.9	-0.7	-0.1	-0.9
Pulse wave peak to peak time	0.7	0.8	3.4	-1.3	0.4	-0.6	-0.5	1.2	0.7	-0.5	-1.8	0.1	-0.1
Health satisfaction	1.1	1.4	5.4	-1.3	-0.5	0.2	0.3	-2.3	-1.4	-0.1	1.8	-0.3	1.1
Shortness of breath walking on level ground	2.3	2.7	6.0	-2.1	0.1	-2.4	-2.4	-1.0	-1.9	-1.7	1.0	-0.7	1.5
Qualifications: College or University degree	0.9	3.0	8.4	1.0	1.8	1.8	1.5	2.9	0.3	2.2	-0.7	2.1	-1.4
Eye problems/disorders: None of the above	0.8	1.0	2.7	1.6	-0.6	0.1	-0.1	0.1	1.3	0.4	1.3	1.0	-1.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.1	0.6	-0.8	-0.5	-0.3	0.5	1.4	0.3	0.4	-0.3	-1.1
Emphysema/chronic bronchitis	1.7	1.9	4.4	-0.0	-0.2	2.0	1.7	-2.1	-1.4	1.0	0.5	1.4	1.5
Medication for pain relief, constipation, heartburn	1.6	2.7	14.2	1.6	3.0	0.5	0.2	-0.3	0.1	0.7	-0.5	3.8	0.3
Neck or shoulder pain in last month	2.1	2.9	6.0	-1.3	-2.4	1.9	1.9	-1.6	-0.7	0.7	-0.8	-2.4	2.1
Medication: Blood pressure	1.1	2.0	9.6	-0.1	3.1	-0.6	-0.4	1.8	1.5	-0.1	-1.2	1.7	-0.1
Angina (self-reported)	0.6	0.7	3.6	-1.9	-1.3	-0.0	0.1	-0.2	-0.1	-0.5	-0.1	0.2	1.2
Migraine (self-reported)	1.0	1.2	4.2	2.0	-1.5	-0.1	-0.5	-0.6	-0.3	0.6	1.7	-1.0	-0.9
Medication: Ibuprofen	1.2	1.5	5.7	0.8	-2.4	-0.5	-0.4	-1.1	-0.3	0.3	1.4	-2.1	0.4
Medication: Allopurinol	1.2	1.6	5.8	1.3	-0.3	1.4	1.5	0.1	0.5	2.4	1.9	-0.4	-0.4
Medication: Omeprazole	0.7	0.8	2.6	-0.6	-0.6	0.5	0.6	-1.5	-0.7	-0.5	1.0	-0.7	1.6
Medication: Seretide 50 evohaler	0.7	0.7	2.1	-0.2	0.4	-0.3	-0.5	-1.4	-1.2	-1.0	0.6	0.4	1.4
Mean time to correctly identify matches	1.3	2.5	7.1	-2.4	1.4	-1.2	-1.2	1.4	-2.0	-1.1	-2.7	-0.5	-0.2
Heart disease (mother)	0.7	0.9	3.2	1.8	-0.7	1.3	1.3	-0.1	0.1	1.0	0.8	0.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.0	-0.2	0.7	1.4	1.4	-1.6	-1.7	1.5	0.6	0.4	0.5
Whole body fat mass	1.9	8.1	22.4	-3.2	-0.6	-4.2	-4.3	-0.1	-1.2	-4.7	-0.4	-3.0	1.1
Leg fat mass (right)	2.7	10.3	31.6	-2.8	-1.0	-5.1	-5.2	-0.0	-0.6	-5.6	-0.0	-3.1	0.6
Arm predicted mass (right)	1.4	7.1	19.4	-1.6	-1.6	-4.2	-4.4	0.6	0.9	-4.4	0.6	-2.8	-0.5
Pulse rate, automated reading	0.5	1.5	6.7	-0.3	-2.6	-0.6	-1.0	-1.5	-0.6	-1.5	-0.4	-1.1	0.7
Alcohol intake frequency.	0.5	1.2	4.3	0.7	-1.4	2.1	1.9	-0.1	0.8	0.9	0.3	0.2	0.5
Comparative height size at age 10	0.3	1.5	7.3	0.0	-2.2	0.5	0.3	1.0	0.3	-0.6	-0.4	-2.7	-0.8
Number of full sisters	1.4	1.7	6.6	-1.1	-1.2	0.4	0.4	-2.6	-1.8	-0.3	0.3	-0.2	1.9
Suffer from ‘nerves’	0.6	0.9	3.7	-0.3	-0.7	1.2	1.3	-0.7	-0.5	1.9	0.3	-0.8	0.4
Overall health rating	1.5	3.2	7.7	-2.1	-1.1	0.6	0.6	-2.8	-2.2	-1.0	1.7	-1.2	2.8
Chest pain or discomfort	0.8	1.1	2.6	-1.6	-1.5	0.7	0.8	-0.5	-0.7	1.1	-0.2	-1.0	1.6
Had major operations	0.8	0.9	2.3	-0.7	1.4	-1.2	-0.9	1.5	1.1	-0.2	0.1	-0.8	-0.7
Age at last live birth	2.8	4.0	9.2	2.7	1.9	0.7	0.6	3.0	2.3	2.5	-0.1	-0.2	-2.7
Family relationship satisfaction	0.9	1.1	3.5	-0.3	-0.7	0.4	0.1	-1.7	-1.9	0.1	0.5	-1.7	1.0
Leg pain on walking	1.5	1.9	3.4	-1.9	-1.0	-1.6	-1.8	-0.9	-1.2	-1.7	0.3	-1.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.4	-0.2	-2.1	-0.9	-0.7	-1.1	0.5	-1.6	0.3	-1.6	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.2	0.1	0.6	-0.0	0.2	-0.2	-0.2	-0.6	-1.1	-0.1	0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.6	0.8	1.5	-0.5	-0.5	-0.6	-1.5	-1.6	-1.3	1.6	0.5
Medication: Aspirin	0.5	0.7	2.1	-1.2	-1.1	-0.7	-0.6	1.4	0.7	0.0	-0.5	-0.1	-0.9
Supplements: Vitamin C	0.4	0.5	2.0	-1.4	-0.1	-0.7	-0.8	0.1	-0.5	-0.1	0.8	-0.4	-0.8
Knee pain experienced in last month	1.0	1.5	5.1	-1.0	-0.6	0.1	-0.1	-1.9	-1.6	-1.0	1.0	0.8	2.3
Hypertension (Self-reported)	0.5	1.3	8.9	-1.4	3.0	-0.5	-0.4	0.7	-0.4	-0.5	0.3	-0.3	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	5.8	-1.3	-1.3	-0.2	-0.3	-0.6	-1.1	-0.6	-0.3	-2.4	0.6
Illnesses of father: Heart disease	2.0	2.8	9.5	-0.7	-3.1	2.3	2.0	-1.0	-0.6	1.5	0.2	-2.0	1.2
Illnesses of siblings: Diabetes	2.5	3.1	12.5	-3.5	0.2	-2.2	-2.1	0.7	-0.1	-2.2	-1.6	-0.9	0.6
Smoking status: Previous	0.7	1.0	4.2	1.6	-0.7	0.0	0.0	0.7	2.0	0.1	-1.1	0.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.4	0.6	-0.6	-0.5	-0.8	-0.2	-0.4	-1.2	0.4	-0.9	0.5
Whole body fat-free mass	1.0	5.6	14.4	-2.2	-1.3	-3.5	-3.8	0.5	0.4	-3.5	0.7	-3.1	-0.3
Leg fat-free mass (right)	0.8	4.2	9.5	-2.6	-0.6	-2.8	-3.1	-0.4	-0.6	-2.8	1.2	-2.7	0.9
Arm fat percentage (left)	1.8	7.4	19.1	-3.5	0.4	-3.9	-3.9	-0.4	-1.9	-4.4	-0.6	-2.2	1.7
Average weekly red wine intake	0.6	0.8	2.5	1.4	1.6	0.4	0.3	0.4	-0.6	-0.2	-0.8	1.6	-0.4
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.5	0.9	0.8	0.4	0.7	2.1	1.9	1.2	-1.1	1.4	-0.7
Mood swings	0.4	0.7	2.4	-1.2	-1.5	-0.4	-0.1	0.1	0.6	0.1	-1.6	-0.8	0.1
Loneliness, isolation	2.1	2.9	8.4	-2.7	-2.7	-1.2	-1.2	-0.7	-1.1	-0.1	0.7	-2.9	0.6
Long-standing illness, disability or infirmity	1.0	1.5	4.4	-0.2	-0.2	1.9	1.8	0.6	0.8	2.1	0.8	-1.0	-0.8
Ever had bowel cancer screening	0.6	0.7	1.8	-0.2	0.3	1.3	1.1	0.8	0.7	1.0	-0.5	-1.1	0.0
Diabetes diagnosed by doctor	0.8	1.3	2.6	-1.5	1.3	-1.6	-1.6	-0.6	0.2	-1.5	0.1	0.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	6.0	0.4	0.3	2.1	2.5	-0.6	0.2	1.1	-0.5	0.1	0.7
Friendships satisfaction	0.5	0.6	2.8	-0.5	-1.4	0.1	0.2	-0.5	-0.7	0.1	-0.5	-1.7	0.3
Qualifications: nursing, teaching	0.8	1.2	3.6	0.5	1.1	1.5	1.3	0.9	-0.9	1.9	-0.3	0.9	-0.9
Commuting to job workplace: Walk	0.9	1.0	5.1	-0.2	0.6	1.3	1.1	0.5	0.9	2.3	-0.2	-0.3	-0.1
Eye problems/disorders: Cataract	0.4	0.5	1.8	-1.1	-0.8	-0.4	-0.4	0.2	0.1	0.6	-1.3	-0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	7.6	1.0	-2.8	1.4	1.5	0.5	1.3	1.7	0.3	-1.2	-1.6
Medication for cholesterol	0.6	0.9	2.4	0.6	0.3	-1.5	-1.5	-0.5	0.1	-1.4	-0.7	1.2	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-1.1	-0.9	0.7	0.7	-0.5	-0.8	1.2	1.0	0.2	0.1
Back pain experienced in last month	2.5	3.7	7.6	-2.1	0.5	2.8	2.6	-0.2	-1.1	2.6	-0.9	-2.2	2.0
Mineral and other dietary supplements	0.3	0.4	1.1	-0.0	0.3	-0.9	-1.1	0.3	-0.1	0.2	0.6	-1.0	-0.4
Breast cancer (self-reported)	2.4	2.9	7.3	-2.7	-2.2	-1.5	-1.8	-1.1	-1.1	-0.2	-1.1	-2.4	1.4
Asthma (self-reported)	0.7	1.3	3.6	-1.7	0.2	-1.1	-1.1	0.5	-0.4	-1.8	-0.4	-1.9	0.5
Osteoporosis (self-reported)	1.4	1.7	3.7	0.0	1.1	-1.8	-1.8	1.4	0.3	-1.9	-1.5	1.1	-0.9
Osteoarthritis (self-reported)	0.2	0.3	0.9	0.1	-0.7	-0.6	-0.3	-0.3	0.9	-0.4	0.7	0.4	-0.1
Medication: Aspirin	0.7	1.0	3.8	-0.8	-0.9	-0.2	-0.2	1.9	1.2	0.4	-1.0	0.4	-1.2
Medication: Gliclazide	1.2	1.3	2.5	-0.4	1.1	-1.6	-1.6	-1.3	0.2	-1.3	1.4	-0.1	1.2
Illnesses of father: None of the above (group 1)	2.2	2.7	5.1	0.7	1.8	-2.2	-2.2	1.3	0.7	-2.3	-1.5	1.5	-1.3
Smoking status: Current	1.3	2.0	6.4	-0.5	-0.7	-2.5	-2.4	-1.5	0.4	-1.7	0.4	-1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	9.0	-2.8	0.3	-1.5	-1.8	-1.3	-3.0	-2.8	-0.7	0.9	2.1
Whole body water mass	1.0	5.6	14.4	-2.2	-1.2	-3.5	-3.8	0.6	0.6	-3.5	0.7	-3.1	-0.3
Leg predicted mass (right)	0.8	4.2	9.5	-2.5	-0.5	-2.7	-3.1	-0.4	-0.6	-2.8	1.2	-2.6	1.0
Arm fat mass (left)	2.0	8.2	22.6	-3.4	-0.3	-4.4	-4.4	-0.1	-1.2	-4.8	-0.2	-2.6	1.0
Number of self-reported non-cancer illnesses	0.5	0.9	4.8	-1.0	-0.7	-0.7	-1.0	0.3	0.8	-0.3	0.3	-2.2	-0.2
Average weekly champagne plus white wine intake	2.3	3.2	6.6	2.2	2.1	0.4	0.5	2.4	1.4	2.1	-0.9	1.7	-2.6
Miserableness	0.5	0.8	4.2	-0.7	-2.0	0.5	0.6	-1.1	-0.5	0.4	-0.4	-1.0	0.6
Guilty feelings	1.2	1.8	5.1	-2.2	-1.4	-0.6	-0.8	-1.1	-1.6	-0.7	-1.8	-1.4	0.8
Wears glasses or contact lenses	0.5	0.6	1.7	-0.1	0.9	0.0	-0.0	1.2	-0.2	-0.3	-1.3	1.1	-0.5
Ever taken oral contraceptive pill	0.5	0.6	1.9	-1.2	-0.3	-0.5	-0.4	0.4	0.1	-1.4	-1.1	-0.4	0.4
Hearing aid user	0.6	0.7	2.3	1.1	0.4	1.5	1.5	0.1	0.4	0.5	-0.1	-0.1	-0.6
Mother’s age at death	0.7	0.9	2.9	1.5	-0.7	0.7	0.4	0.5	-0.0	1.0	0.8	1.7	-0.7
Financial situation satisfaction	0.8	1.0	2.5	-0.8	-1.6	-1.1	-1.2	-1.2	-0.9	-1.0	1.0	-0.3	0.3
Tinnitus: Yes, now most or all of the time	2.0	2.3	8.6	-0.2	-0.7	0.2	-0.1	-2.9	-2.0	-1.1	2.0	-0.8	1.9
Commuting to job workplace: Public transport	0.4	0.4	2.0	0.0	1.4	-0.6	-0.7	0.0	0.1	-0.7	0.5	0.6	0.6
Eye problems/disorders: Glaucoma	0.9	1.1	7.4	-0.9	0.1	-0.2	0.2	0.0	-1.4	-0.6	0.4	-2.7	0.3
Medication: Blood pressure	0.6	1.1	6.3	-1.1	2.5	0.2	0.3	1.0	-0.5	0.1	0.9	-1.1	0.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.5	-1.1	-0.0	1.3	1.4	-1.5	-1.5	-0.1	0.8	-1.0	1.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.5	-0.5	0.7	0.7	-0.6	-0.5	-0.0	0.0	0.8	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.7	-0.1	1.3	0.6	0.7	0.5	0.9	0.5	-1.2	-0.2	0.0
Medication: Bendroflumethiazide	0.9	1.3	3.1	-1.7	1.6	-0.8	-0.5	-0.1	-1.2	-1.4	0.8	-1.6	0.3
Medication: Paracetamol	1.0	1.5	9.7	-0.8	-1.1	1.0	1.1	0.4	-0.8	-0.3	-0.7	-3.1	-0.4
Medication: Lisinopril	0.9	1.2	3.0	-1.1	1.5	1.6	1.7	-0.3	-0.6	0.4	0.6	-0.2	1.4
Medication: Atorvastatin	1.1	1.4	6.2	-2.5	0.3	-0.2	-0.1	-0.8	-1.3	-1.2	-1.4	-0.1	1.4
Illnesses of father: High blood pressure	1.7	2.2	5.7	-0.1	-0.8	2.1	2.2	0.4	0.1	2.4	0.7	-2.1	-0.8
Alcohol drinker status: Never	1.4	1.6	4.6	0.3	0.5	0.6	0.8	-2.1	-0.7	0.6	2.1	1.0	2.0
Ever smoked	0.7	1.3	5.0	1.8	-0.4	-0.3	-0.2	0.7	2.2	0.6	-1.4	1.2	-0.6
Basal metabolic rate	1.1	6.3	15.7	-2.5	-1.2	-3.7	-4.0	0.3	0.1	-3.9	0.6	-3.2	0.1
Leg fat percentage (left)	2.0	7.4	22.2	-2.1	-0.8	-4.5	-4.4	0.1	-0.4	-4.7	-0.2	-2.7	0.2
Arm fat-free mass (left)	1.3	6.5	16.7	-2.0	-1.6	-3.8	-4.1	0.9	1.0	-4.0	0.4	-2.9	-0.8
Number of operations (self-reported)	0.6	0.9	2.3	-0.9	-0.7	-0.3	-0.4	-0.5	-1.5	-0.8	0.4	-1.5	1.2
Average weekly beer plus cider intake	3.3	4.8	13.4	-2.2	-0.2	-3.6	-3.3	-0.6	0.1	-3.7	-0.1	-1.6	1.5
Irritability	0.8	1.4	5.0	-1.3	-2.2	-1.2	-1.1	-1.2	0.1	-0.4	-0.3	-1.4	0.8
Risk taking	1.1	1.6	4.7	-2.0	-1.0	-1.1	-1.2	-0.4	-1.3	-1.2	-0.8	-2.2	0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	6.5	1.3	2.2	-0.2	-0.2	2.5	1.3	0.7	-0.9	2.2	-1.0
Fractured/broken bones in last 5 years	1.8	2.3	3.8	-0.8	-1.9	-1.6	-1.7	-1.8	-1.2	-1.2	1.1	-1.9	1.5
Age started oral contraceptive pill	0.5	0.7	2.1	-0.7	-0.6	-0.8	-1.2	0.5	-0.5	-0.8	-0.0	-0.5	-1.5
Diastolic blood pressure, automated reading	1.1	3.4	10.6	-2.7	0.8	-2.2	-2.0	1.3	-1.2	-1.8	-0.4	-3.2	0.6
Ever depressed for a whole week	1.5	1.8	6.8	-1.4	-2.3	0.3	0.5	-0.8	-1.6	0.8	0.1	-2.6	0.2
Unable to work because of sickness or disability	1.0	1.3	3.8	-2.0	-1.2	0.5	0.5	-1.5	-1.6	0.1	1.1	-0.2	1.1
Commuting to job workplace: Cycle	0.9	1.1	4.3	0.3	-0.2	2.0	2.1	-0.3	0.3	1.1	-0.5	0.1	0.7
Myopia	0.7	0.9	3.6	1.9	-0.1	-0.2	-0.4	-0.1	1.0	0.5	1.6	1.1	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	7.1	1.9	-2.7	0.4	0.2	-0.6	0.2	0.0	-0.8	0.8	-1.2
Cholesterol lowering medication	0.3	0.5	1.5	0.2	0.1	0.8	0.8	1.0	0.5	0.6	-1.2	-0.5	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.4	-1.0	-0.8	0.5	0.6	-1.8	-0.8	-0.8	0.7	-0.8	1.8
Pain experienced in last month	2.4	4.0	10.5	0.3	1.1	-2.9	-2.8	0.2	-0.1	-3.2	-0.4	3.2	-1.0
Supplements: Calcium	1.0	1.1	4.2	0.7	1.7	-0.3	-0.3	2.0	0.9	-0.2	-1.1	-0.6	-0.8
Basal cell carcinoma (self-reported)	1.5	1.8	5.5	1.7	1.1	-1.3	-1.4	1.5	1.1	0.3	-0.6	0.7	-2.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	0.5	0.1	0.1	0.4	0.6	0.7	0.7	-0.7	1.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.9	-0.2	-0.7	-0.8	-1.0	-2.0	-1.5	-1.2	0.7	0.5	1.7
Heart disease (siblings)	1.2	1.4	8.0	-0.7	-2.8	0.4	0.4	-1.2	-0.8	1.3	1.2	-0.3	0.7
Alcohol drinker status: Previous	0.7	0.8	1.8	0.9	-0.2	1.4	1.2	0.3	-0.1	-0.7	-1.0	1.0	1.2
Pack years of smoking	0.1	0.2	1.1	-0.4	-0.4	-0.0	0.3	-1.0	0.1	-0.5	-0.2	-0.0	0.5
Impedance of whole body	0.8	4.2	12.9	1.7	-0.0	3.4	3.6	0.4	-0.5	3.0	-2.3	0.2	-0.4
Leg fat mass (left)	2.4	9.2	27.3	-2.5	-0.9	-4.9	-5.0	-0.0	-0.4	-5.2	0.2	-2.9	0.4
Arm predicted mass (left)	1.2	6.3	16.0	-1.9	-1.7	-3.7	-4.0	0.5	0.7	-3.9	0.9	-3.1	-0.6