TWAS hub - TSTA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0700	0.0320	3.2e-03	0.015	NA	0.045	NA	0.018	2.1e-02	NA	1.4e-04	NA	1.2e-02
2	GTEx	Muscle Skeletal	0.0691	0.0299	2.1e-03	0.003	NA	0.004	NA	0.003	1.4e-01	NA	1.2e-01	NA	1.6e-01
3	METSIM	Adipose	0.0528	0.0188	2.1e-04	0.003	0.016	0.005	0.013	0.006	1.2e-01	1.5e-03	4.5e-02	3.4e-03	3.1e-02
4	YFS	Blood	0.0609	0.0182	1.2e-06	0.022	0.024	0.031	0.033	0.036	7.3e-08	2.0e-08	1.3e-10	6.2e-11	5.2e-12
5	TCGA	Stomach Adenocarcinoma	0.0800	0.0420	3.0e-03	0.003	0.009	0.015	NA	0.007	1.7e-01	6.4e-02	2.7e-02	NA	9.9e-02
6	TCGA	Thyroid Carcinoma	0.0340	0.0210	8.8e-03	0.018	0.025	0.032	NA	0.030	6.3e-03	1.7e-03	4.0e-04	NA	6.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	5	6
Migraine (self-reported)	3.1	3.9	8.7	-0.8	-2.9	2.3	2.9
Pain all over the body in last month	2.8	3.0	8.5	-2.9	-0.7	2.4	1.7
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	9.2	2.0	2.6	0.9	-3.0
Pulse rate	2.1	3.5	10.7	-1.0	-3.3	2.6	1.6
Commuting to job workplace: Cycle	2.0	2.4	10.8	3.3	-1.3	1.5	-0.2
Osteoarthritis (self-reported)	1.9	2.5	6.1	-2.4	0.8	1.6	2.5
Alcohol intake versus 10 years previously	1.8	2.7	7.5	-2.7	1.7	-0.3	2.4
Breastfed as a baby	1.8	2.2	9.5	3.1	-1.6	0.9	-0.6
Number of children fathered	1.8	2.0	7.9	1.5	0.9	2.8	1.0
Relative age of first facial hair	1.7	3.5	9.7	-1.9	3.1	-2.0	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	10.6	-0.0	2.6	-3.3	-2.5
Blood Platelet Count	1.6	18.5	57.6	2.6	-7.6	6.2	2.8
Number of full brothers	1.6	2.1	9.3	0.5	3.0	-1.7	-0.0
Hearing aid user	1.6	1.8	6.0	-1.5	-2.4	0.3	1.5
Risk taking	1.6	2.4	6.6	2.6	2.4	0.7	-1.3
Primary Biliary Cirrhosis	1.5	2.1	3.5	1.6	1.9	-1.8	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	6.7	1.5	2.5	-2.1	-2.6
Pulse rate, automated reading	1.5	4.8	14.3	-2.0	-3.8	1.4	2.8
Neuroticism (2016)	1.4	2.1	5.3	-2.3	-0.6	1.6	2.0
High blood pressure (mother)	1.4	2.0	10.6	3.3	0.6	1.1	-0.1
Medication: Ramipril	1.4	1.8	3.6	1.9	1.9	1.4	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.8	-2.2	2.2	0.8	0.7
Depression (self-reported)	1.4	1.7	5.1	-1.5	-2.3	1.0	1.3
Worry too long after embarrassment	1.4	2.3	8.1	-1.0	-2.9	2.2	0.5
Mean time to correctly identify matches	1.4	2.7	8.6	-2.0	2.9	-1.6	-1.1
Knee pain experienced in last month	1.4	2.1	9.4	1.0	3.1	-1.0	-1.2
Eye problems/disorders: Glaucoma	1.4	1.6	6.9	2.6	-0.5	1.6	0.1
Length of working week for main job	1.3	1.4	4.3	-1.9	0.1	0.9	2.1
Hair/balding pattern: Pattern 4	1.3	3.2	8.2	-1.2	-2.5	1.7	2.9
Supplements: Vitamin C	1.3	1.5	5.2	-1.4	-0.8	1.1	2.3
Medication: Gliclazide	1.3	1.5	5.0	1.4	-2.2	1.4	-0.4
Loud music exposure frequency	1.2	1.3	4.7	-1.7	-0.3	-2.2	-0.0
Wheeze or whistling in the chest in last year	1.2	2.1	10.4	-0.2	3.2	-1.2	-0.8
Medication: Ibuprofen	1.2	1.4	3.8	-1.9	1.5	1.2	0.9
Osteoporosis (self-reported)	1.2	1.5	5.9	2.4	1.2	-0.4	-1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	5.3	1.1	-0.1	-1.2	-2.3
Impedance of arm (right)	1.1	5.1	13.7	3.7	-2.4	3.3	-0.8
Pulse wave reflection index	1.1	1.4	6.9	-1.1	2.6	-0.3	0.0
Medication: Blood pressure	1.1	2.2	7.8	1.1	1.2	-1.6	-2.8
Medication: Lisinopril	1.1	1.4	4.3	-2.1	0.1	-2.1	-0.1
Ever had prostate specific antigen (PSA) test	1.1	1.2	4.9	2.2	-0.6	-0.2	-1.5
Hair/balding pattern: Pattern 2	1.0	1.3	5.9	-0.6	0.8	0.9	2.4
Pulse wave Arterial Stiffness index	1.0	1.2	3.7	-1.9	1.4	-0.4	1.0
Peak expiratory flow (PEF)	1.0	2.4	9.1	3.0	-1.6	-0.9	-1.4
Pulse wave peak to peak time	1.0	1.2	4.0	2.0	-1.5	0.6	-0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.3	-1.1	1.4	-1.8	-0.9
Long-standing illness, disability or infirmity	1.0	1.5	4.0	-0.8	-0.6	2.0	1.9
Qualifications: nursing, teaching	1.0	1.5	6.2	2.5	-0.7	-0.7	-1.3
Reaction Time	0.9	1.7	6.9	-1.5	2.6	-0.8	-0.6
Average weekly spirits intake	0.9	1.1	3.1	0.4	-0.9	1.8	1.5
Medication for hormone replacement therapy	0.9	1.0	2.6	-1.2	-1.6	1.0	0.9
Average weekly fortified wine intake	0.9	1.1	3.9	-0.7	2.0	-0.9	-1.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	4.0	-0.5	0.6	0.9	2.0
Number of incorrect matches in round	0.9	1.4	6.3	-0.6	2.5	-0.4	-1.3
Impedance of arm (left)	0.9	4.3	12.1	3.5	-1.8	3.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.4	1.4	0.5	-1.8	-1.7
Glaucoma (self-reported)	0.9	1.1	5.4	2.3	0.3	1.0	-0.3
Medication: Amlodipine	0.9	1.3	4.8	0.7	-1.3	2.2	-0.9
Chest pain or discomfort	0.9	1.3	6.3	-0.3	2.5	-0.1	-1.2
Illnesses of siblings: Diabetes	0.9	1.1	5.2	-0.9	-2.3	0.0	0.8
Ever had bowel cancer screening	0.9	1.0	3.4	0.4	-1.5	1.8	-0.6
LDL Cholesterol	0.8	1.3	4.6	2.2	-1.6	0.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.0	-1.3	1.7	0.6	0.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	5.0	-2.2	0.1	-0.3	-0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	5.8	2.4	-1.5	-0.7	-0.1
Heart disease (mother)	0.8	1.0	3.3	0.2	-1.4	-0.9	1.8
Had major operations	0.8	0.9	2.7	-1.4	1.6	-0.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.0	-0.2	0.7	-1.3	-1.7
Eye problems/disorders: Cataract	0.8	0.9	3.9	-2.0	-0.2	0.3	1.2
Smoking status: Current	0.8	1.3	5.6	-0.3	2.4	-0.9	-1.1
Ever taken oral contraceptive pill	0.8	0.8	3.1	-0.9	-0.9	0.6	1.8
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.8	-0.8	1.2	-1.1	1.7
Depression (Nagel 2018)	0.7	1.1	3.0	-1.4	-1.2	1.7	0.4
Schizophrenia vs Biploar Disorder	0.7	1.0	2.8	-1.7	1.3	0.1	-1.1
Worry (Nagel 2018)	0.7	1.6	6.6	-2.6	-1.6	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.1	-1.2	-1.4	1.0	1.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	3.2	0.7	-1.8	0.7	0.4
Current tobacco smoking	0.7	1.1	4.0	-0.8	2.0	-1.0	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.9	-1.4	-1.2	1.3	0.7
Taking other prescription medications	0.7	1.1	2.9	-1.7	-0.8	0.9	1.4
Stomach or abdominal pain in last month	0.7	0.8	2.1	0.3	1.4	-1.1	-1.3
Supplements: Glucosamine	0.7	1.0	3.8	-1.4	-0.2	0.3	1.9
Medication: Atenolol	0.7	0.9	2.3	1.0	0.9	-1.1	-1.5
Hearing difficulty/problems with background noise	0.7	1.1	3.8	0.8	-2.0	0.1	1.4
Fluid intelligence score	0.7	1.6	5.5	1.2	-1.5	2.4	-0.4
Mouth/teeth dental problems: Dentures	0.7	1.2	3.8	-2.0	-0.5	0.4	1.8
Illnesses of mother	0.7	0.9	4.3	-2.1	-0.9	0.5	0.1
Blood clot in the leg (DVT)	0.7	0.9	2.4	-0.9	0.8	-1.3	1.5
Medication: Blood pressure	0.7	1.2	2.8	-1.4	0.5	1.5	1.7
Smoking status: Previous	0.7	1.1	2.8	-1.7	-1.0	0.2	1.6
Diabetes diagnosed by doctor	0.7	1.1	4.0	0.2	-1.2	-1.1	-2.0
Commuting to job workplace: Walk	0.7	0.7	1.8	0.6	0.8	-1.2	-1.3
Financial situation satisfaction	0.7	0.9	1.9	1.4	-1.4	1.2	-0.0
Medication: Co-codamol	0.6	0.7	3.1	-0.4	-0.0	1.0	1.8
Maternal smoking around birth	0.6	0.9	4.3	-2.1	-0.9	-0.5	-0.3
Relative age voice broke	0.6	0.9	3.2	-1.8	1.1	-0.5	-0.7
Serious illness, injury or assault to yourself	0.6	0.7	2.5	0.5	-0.7	1.6	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.3	0.4	-0.9	1.5	1.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	3.8	0.7	1.9	-0.4	-0.2
Time employed in main current job	0.6	0.6	3.1	-0.7	-1.8	-0.5	0.1
Father’s age at death	0.6	0.8	3.8	-2.0	-0.3	0.8	0.7
Hair/balding pattern: Pattern 3	0.6	0.8	3.1	0.8	1.1	0.1	-1.8
Asthma	0.6	1.1	3.6	-0.3	1.9	0.4	1.7
Medication: Cholesterol lowering	0.6	0.9	1.9	-0.8	-1.3	1.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.5	-1.3	-0.9	-0.5	1.6
Gout (self-reported)	0.6	0.9	3.2	-1.8	1.2	0.6	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.1	-1.4	0.2	0.4	1.4
Number of full sisters	0.6	0.8	3.0	1.2	-1.7	-0.2	0.3
Suffer from ‘nerves’	0.6	0.9	3.3	-1.8	-0.7	0.3	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.8	-1.1	-1.3	-0.6	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.9	0.7	-2.0	-0.5	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	-1.0	0.9	1.3	0.7
Wears glasses or contact lenses	0.6	0.7	3.6	-1.9	-0.5	-0.1	0.5
Leg fat percentage (left)	0.6	2.2	7.2	-2.1	2.7	-0.9	0.9
Number of operations (self-reported)	0.6	0.9	3.4	-1.4	1.8	0.4	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	2.7	-1.0	-1.6	0.7	0.4
Bipolar Disorder (2018)	0.5	0.8	3.9	-0.3	-2.0	-0.7	0.7
Neuroticism (Nagel 2018)	0.5	1.2	6.1	-2.5	-1.1	-0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	5.6	-0.0	-2.4	1.2	0.5
Rheumatoid Arthritis	0.5	0.7	3.2	0.8	1.8	0.2	-0.3
Respiratory disease	0.5	1.1	3.5	0.3	1.9	0.9	1.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.7	0.4	-1.6	-1.0	-1.2
Sensitivity / hurt feelings	0.5	0.9	4.7	0.4	-2.2	0.6	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.7	-0.6	1.6	0.7	-0.2
Age when periods started (menarche)	0.5	1.1	4.2	1.4	-2.0	0.4	-0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.2	-1.1	1.1	0.4	0.8
Past tobacco smoking	0.5	0.9	3.0	1.7	0.5	-0.0	-1.4
Diabetes (self-reported)	0.5	0.8	1.6	-0.3	-1.2	-1.2	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	2.6	0.3	-1.6	1.0	0.9
Leg fat percentage (right)	0.5	1.8	5.1	-2.3	2.0	-0.6	1.3
Age at first live birth	0.5	0.9	2.2	1.4	-1.5	0.8	-0.5
Emphysema/chronic bronchitis	0.5	0.5	1.7	1.1	1.3	-0.5	0.3
Angina (self-reported)	0.5	0.6	1.8	-1.2	0.7	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.9	2.2	-1.0	0.1	-0.6
Back pain experienced in last month	0.5	0.7	1.4	1.0	1.2	-0.9	1.0
Asthma (self-reported)	0.5	0.9	2.8	-0.3	1.7	0.5	1.6
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	-1.4	0.4	0.1	1.3
Medication: Atorvastatin	0.5	0.7	2.2	-0.3	-1.5	1.3	-0.4
Illnesses of father: High blood pressure	0.5	0.6	2.1	0.2	-1.4	1.3	-0.1
Ever smoked	0.5	0.8	2.3	-1.5	-0.6	-0.5	1.3
Ever depressed for a whole week	0.5	0.6	3.3	-0.2	-1.8	0.0	0.6
Unable to work because of sickness or disability	0.5	0.7	2.6	-1.6	0.0	0.8	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.8	1.4	-2.2	0.9	0.4
Mean Putamen Volume	0.4	0.5	2.4	0.4	1.5	-0.5	-0.5
Fasting Glucose	0.4	0.5	1.9	0.5	1.0	0.1	-1.4
Neuroticism	0.4	0.9	3.6	-1.9	-1.3	-0.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.2	0.0	0.4	1.5	-0.7
Angina	0.4	0.6	1.6	-1.2	0.7	1.2	0.0
Medication: Metformin	0.4	0.5	1.6	0.6	-1.3	-0.4	-1.1
Diabetes (mother)	0.4	0.5	2.5	-0.4	1.6	-0.7	-0.2
Heart attack	0.4	0.5	3.0	-1.7	0.0	-0.2	-0.2
Neuroticism score	0.4	0.8	3.7	-1.9	-1.0	-0.2	-0.1
Medication: Lansoprazole	0.4	0.5	1.1	-1.0	-0.7	0.6	1.1
Prospective memory result	0.4	0.5	1.5	-1.2	0.9	-0.7	-0.2
Exposure to tobacco smoke at home	0.4	0.4	1.5	-0.4	1.2	0.9	0.4
Tense / ‘highly strung’	0.4	0.6	2.5	-1.6	0.9	-0.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	1.0	-0.7	1.0	-1.1
Shortness of breath walking on level ground	0.4	0.5	1.3	-1.0	-0.9	-1.1	0.4
Eye problems/disorders: None of the above	0.4	0.5	1.4	-0.9	1.2	-0.8	-0.5
Medication: Allopurinol	0.4	0.5	1.1	-1.1	1.0	-0.8	0.4
Family relationship satisfaction	0.4	0.5	1.0	-1.0	-0.7	0.9	0.7
Leg pain on walking	0.4	0.5	1.9	0.8	-1.4	0.7	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.0	1.4	-0.5	0.7	0.4
Loneliness, isolation	0.4	0.6	1.8	-1.3	-0.9	0.5	0.8
Average weekly champagne plus white wine intake	0.4	0.6	1.6	-0.4	-1.3	0.9	1.0
Guilty feelings	0.4	0.7	2.6	-0.8	0.9	-1.6	-0.3
Mother’s age at death	0.4	0.5	1.4	-0.7	0.1	-1.1	1.2
Medication: Bendroflumethiazide	0.4	0.6	2.1	-1.0	1.4	-0.5	-0.1
Alcohol drinker status: Never	0.4	0.4	1.5	0.0	-1.2	0.9	0.5
Age started oral contraceptive pill	0.4	0.5	1.8	-0.3	-0.1	-1.3	-1.0
Cholesterol lowering medication	0.4	0.6	2.5	1.6	-0.2	0.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	3.1	-1.8	-0.3	0.2	0.0
Alcohol drinker status: Previous	0.4	0.5	1.2	1.1	-1.0	0.7	0.1
Depressed Affect (Nagel 2018)	0.3	0.6	3.3	-1.8	-0.0	-0.0	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	1.4	-0.7	0.3	-1.2	-0.5
Alzheimer’s Disease (in father)	0.3	0.3	1.4	0.5	1.2	0.1	0.3
Crohns Disease (2017)	0.3	0.6	2.6	-0.4	0.8	-0.2	-1.6
Breast Cancer	0.3	0.7	3.8	0.0	0.3	0.4	2.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.8	0.5	1.3	-0.1	-0.8
HDL Cholesterol	0.3	0.5	2.6	-1.6	-0.2	-0.1	-0.5
Triglycerides	0.3	0.6	2.4	0.3	0.4	1.5	0.8
Ulcerative Colitis	0.3	0.5	2.1	-0.1	0.6	1.5	0.7
Blood Red Count	0.3	3.2	12.1	-2.0	3.5	-1.2	-1.1
Heel T-Score	0.3	2.6	5.4	1.7	2.2	-1.5	-2.3
Smoking Status	0.3	0.8	3.4	-1.8	0.9	-0.6	0.5
Chronotype (morning person)	0.3	0.8	2.1	1.2	-0.1	-1.4	-1.2
Number of treatments/medications taken	0.3	0.6	2.5	-0.7	-0.8	1.6	0.3
Hearing difficulty/problems: Yes	0.3	0.5	2.0	-0.5	-1.4	-0.1	0.9
Vitamin and mineral supplements	0.3	0.4	1.1	1.1	-0.7	-0.8	-0.3
Diabetes (father)	0.3	0.4	1.8	-0.5	-1.3	0.3	0.7
Severe depression (siblings)	0.3	0.4	1.1	1.0	-0.3	-0.7	-0.8
Townsend deprivation index at recruitment	0.3	0.4	1.3	-0.9	0.6	-1.1	0.4
Medication: Levothyroxine sodium	0.3	0.6	3.3	0.2	-0.3	1.8	0.0
Body mass index (BMI)	0.3	1.1	3.1	-1.8	1.6	-0.9	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.2	-1.0	-1.0	0.5
Qualifications: None of the above	0.3	0.6	2.3	-0.4	1.5	-1.1	-0.1
Allergy	0.3	0.7	1.9	0.5	-1.4	0.9	-1.1
Worrier / anxious feelings	0.3	0.6	1.3	-1.2	-0.6	-0.7	-1.1
Falls in the last year	0.3	0.4	2.1	0.0	0.4	-1.5	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.7	2.2	-1.2	0.0	0.7
Happiness	0.3	0.3	1.1	0.1	-1.0	0.4	-0.9
Lung cancer (father)	0.3	0.4	1.5	-0.1	0.8	0.1	1.2
Birth weight of first child	0.3	0.5	1.5	0.1	0.9	-1.2	-0.8
Birth weight	0.3	0.6	3.6	0.3	-0.4	0.0	1.9
Exposure to tobacco smoke outside home	0.3	0.4	2.2	-1.5	0.4	0.1	0.5
Comparative body size at age 10	0.3	0.8	3.5	-0.7	0.8	-1.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.6	-0.4	0.6	-1.3	0.0
Health satisfaction	0.3	0.4	1.0	-0.6	-1.0	-0.7	-0.7
Leg fat mass (right)	0.3	1.0	2.7	-1.6	1.4	-0.7	1.0
Comparative height size at age 10	0.3	1.7	3.7	1.9	-1.6	1.3	-1.6
Overall health rating	0.3	0.7	2.7	-1.6	0.3	-1.0	-0.4
Medication: Aspirin	0.3	0.4	1.0	-1.0	0.7	0.5	0.8
Mood swings	0.3	0.6	1.8	-1.3	0.7	-1.2	-0.2
Friendships satisfaction	0.3	0.3	0.8	-0.7	-0.9	-0.1	0.8
Medication for cholesterol	0.3	0.5	2.3	-0.3	0.4	0.8	1.5
Mineral and other dietary supplements	0.3	0.4	1.2	0.9	-0.5	0.0	-1.1
Breast cancer (self-reported)	0.3	0.3	1.2	-0.6	0.5	1.1	0.5
Medication: Aspirin	0.3	0.4	1.1	-0.7	0.2	0.8	1.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.2	-0.9	0.9	1.1	0.3
Irritability	0.3	0.5	2.6	-1.6	-0.2	0.0	0.5
Myopia	0.3	0.4	1.3	-0.1	0.1	1.1	-1.1
Impedance of whole body	0.3	1.3	4.5	1.6	-0.8	2.1	-0.1
Leg fat mass (left)	0.3	1.0	2.7	-1.4	1.6	-0.8	0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	1.4	0.1	0.3	-1.2	-0.7
Ulcerative Colitis (UC)	0.2	0.4	1.7	-0.0	-0.1	1.3	0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.0	0.0	-0.8	-0.7
Schizophrenia (2014)	0.2	0.4	1.7	-0.6	0.3	-0.5	-1.3
Blood Eosinophil Count	0.2	1.5	6.9	2.6	1.3	-0.5	0.6
Blood White Count	0.2	1.6	4.5	-2.1	0.3	1.8	1.3
BMI	0.2	1.3	5.2	-2.3	1.1	0.7	0.9
Lung FEV1/FVC ratio	0.2	0.9	3.4	1.8	-1.2	0.5	0.5
Tanning	0.2	2.1	6.6	-2.6	1.9	-1.2	0.9
Hand grip strength (left)	0.2	0.7	2.9	-0.2	-1.7	0.5	0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.7	-0.4	1.2	-0.4
Supplements: Zinc	0.2	0.2	0.7	-0.8	0.5	0.0	0.4
Hand grip strength (right)	0.2	0.6	2.9	-0.5	-1.7	-0.7	0.2
Fed-up feelings	0.2	0.4	1.7	-0.7	0.6	-1.3	-0.1
Sitting height	0.2	1.1	4.6	2.1	-0.2	-0.9	-1.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	-0.5	0.5	0.8	-0.7
Had menopause	0.2	0.3	1.0	-0.4	0.7	-0.4	-1.0
Had other major operations	0.2	0.3	0.9	0.6	1.0	0.4	0.1
Financial difficulties in last 2 years	0.2	0.3	1.1	0.2	-0.4	0.8	1.1
Medication: Simvastatin	0.2	0.3	0.8	0.8	-0.4	0.9	-0.1
Illnesses of siblings	0.2	0.3	1.3	1.1	0.2	0.1	-0.7
Number of live births	0.2	0.3	1.5	0.3	0.2	-1.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	0.5	-0.5	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.5	1.2	-1.0	-0.8	0.9
Standing height	0.2	2.4	7.9	2.8	-1.9	0.5	-1.6
Medication: Paracetamol	0.2	0.3	1.2	-0.4	-0.4	0.6	-1.1
Headache pain in last month	0.2	0.3	0.9	-1.0	-0.8	0.1	0.1
Body fat percentage	0.2	0.7	2.0	-1.3	1.4	0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.8	0.5	0.5	-0.3
Medication: Omeprazole	0.2	0.3	1.0	0.2	0.7	0.2	-1.0
Medication: Seretide 50 evohaler	0.2	0.2	1.0	-0.5	0.1	1.0	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.9	0.0	0.8	0.5
Alcohol intake frequency.	0.2	0.4	1.8	-0.4	-1.3	-0.5	-0.3
Average weekly red wine intake	0.2	0.2	0.7	-0.2	0.4	-0.9	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.3	-1.1	-0.4	-0.1	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	1.0	-0.7	0.2	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.7	1.3	-1.0	-0.3	0.5
Commuting to job workplace: Public transport	0.2	0.3	1.4	-1.2	-0.2	-0.2	-0.2
Pain experienced in last month	0.2	0.4	1.0	-0.6	-1.0	0.5	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	-0.2	-0.8	-0.3	-0.4
Schizophrenia (2018)	0.1	0.2	1.1	-0.1	0.5	0.2	-1.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.7	-0.3	0.9	0.3	-0.8
Ovarian Cancer	0.1	0.2	0.8	0.4	0.9	-0.4	-0.0
Age at First Birth	0.1	0.2	0.8	0.2	-0.3	0.9	-0.3
Crohns Disease (2012)	0.1	0.2	0.4	-0.7	0.6	0.3	-0.3
HbA1C	0.1	0.1	0.5	-0.1	0.4	-0.3	0.7
Lupus	0.1	0.1	0.5	0.2	0.7	0.1	-0.2
Height	0.1	2.7	11.2	2.0	-3.3	0.9	0.2
Waist Hip Ratio (WHR)	0.1	0.6	1.4	-0.6	0.9	1.0	-1.2
Cardiovascular Disease	0.1	0.3	1.5	-0.4	-0.0	-0.4	-1.2
Lung FVC	0.1	0.6	3.3	0.1	-0.2	-0.4	1.8
Pack years adult smoking proportion	0.1	0.2	0.8	-0.6	0.1	-0.0	0.9
Impedance of leg (right)	0.1	0.4	1.2	-0.8	-0.1	1.1	0.5
Leg fat-free mass (left)	0.1	0.3	0.8	0.9	-0.9	-0.3	-0.3
Trunk fat percentage	0.1	0.3	0.7	-0.8	0.7	0.7	0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.6	-0.3	-0.2	-0.5	0.8
Multivitamins +/- minerals	0.1	0.2	0.6	-0.7	-0.0	0.6	-0.2
Leg predicted mass (left)	0.1	0.3	0.8	0.9	-0.9	-0.2	-0.3
Waist circumference	0.1	0.3	0.7	-0.8	0.6	-0.7	-0.2
Alcohol usually taken with meals	0.1	0.2	0.9	-0.9	-0.6	-0.1	-0.2
Nervous feelings	0.1	0.3	1.2	-1.1	-0.4	0.0	-0.4
Forced vital capacity (FVC)	0.1	0.5	2.6	1.6	-0.4	-0.1	0.6
Mouth/teeth dental problems	0.1	0.1	0.4	-0.3	-0.6	0.2	0.6
Trunk fat-free mass	0.1	0.5	1.8	0.3	-0.5	-1.3	-0.9
Hip circumference	0.1	0.2	0.7	0.8	-0.3	-0.7	0.1
Noisy workplace	0.1	0.2	0.6	-0.8	-0.0	-0.6	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.6	-0.3	0.4	-0.8
Arm fat mass (right)	0.1	0.2	0.8	-0.9	0.7	-0.3	0.2
Trunk predicted mass	0.1	0.4	1.4	0.3	-0.6	-1.2	-0.9
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.3	0.4	0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.5
High blood pressure (siblings)	0.1	0.2	0.6	-0.8	0.4	0.1	0.7
Forced vital capacity (FVC), Best measure	0.1	0.4	1.3	0.8	0.1	-1.1	0.5
Arm fat-free mass (right)	0.1	0.5	1.9	-1.0	0.1	-1.4	-0.1
Qualifications: College or University degree	0.1	0.3	0.9	0.7	0.2	-0.1	-1.0
Neck or shoulder pain in last month	0.1	0.2	1.0	1.0	0.4	0.0	-0.1
Whole body fat mass	0.1	0.6	1.9	-1.4	1.2	-0.1	0.4
Arm predicted mass (right)	0.1	0.6	2.5	-1.0	0.2	-1.6	-0.3
Age at last live birth	0.1	0.2	0.9	0.1	-0.9	-0.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	-0.5	0.5	0.6	0.0
Illnesses of father: Heart disease	0.1	0.1	0.3	0.1	0.2	-0.5	0.6
Whole body fat-free mass	0.1	0.3	1.3	0.4	-0.5	-1.1	-0.7
Leg fat-free mass (right)	0.1	0.4	1.5	1.2	-0.7	-0.5	-0.6
Arm fat percentage (left)	0.1	0.2	1.0	-0.2	1.0	0.3	0.3
Whole body water mass	0.1	0.3	1.2	0.2	-0.5	-1.1	-0.7
Leg predicted mass (right)	0.1	0.4	1.5	1.2	-0.7	-0.5	-0.6
Arm fat mass (left)	0.1	0.3	0.9	-0.8	0.9	-0.1	0.1
Miserableness	0.1	0.2	0.8	-0.3	0.9	-0.3	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.6	-0.4	-0.1	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.6	0.3	-0.4	0.3
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.1	-0.9	0.6	-0.2
Medication: Paracetamol	0.1	0.1	0.3	-0.5	-0.4	0.3	-0.3
Arm fat-free mass (left)	0.1	0.5	2.2	-0.8	0.3	-1.5	-0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.4	0.7	-0.0	0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.1	0.5	0.4	-0.7	0.1	0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.6	0.7	-0.0	-0.6
Supplements: Calcium	0.1	0.1	0.3	-0.4	-0.2	0.5	-0.6
Heart disease (siblings)	0.1	0.1	0.7	-0.8	0.1	-0.2	0.2
Pack years of smoking	0.1	0.2	0.4	-0.6	0.4	-0.4	0.7
Arm predicted mass (left)	0.1	0.6	2.3	-1.0	0.2	-1.5	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.1	0.2	0.3	0.2	0.5	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.1	0.6	-0.1	0.8	0.4	-0.1
Allergy or Eczema	0.0	0.1	0.4	0.2	0.7	0.4	0.3
Hypothyroidism (self reported)	0.0	0.1	0.4	-0.1	-0.6	0.1	0.2
Hair Pigment	0.0	0.4	2.1	1.5	0.0	-0.3	-0.5
Systolic blood pressure, automated reading	0.0	0.1	0.6	-0.1	0.8	-0.2	0.4
High blood pressure	0.0	0.1	0.3	-0.2	0.5	-0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.2	0.2	-0.4	0.1
Impedance of leg (left)	0.0	0.2	0.6	-0.6	0.7	0.6	0.3
Trunk fat mass	0.0	0.2	0.6	-0.8	0.7	0.3	0.3
Weight	0.0	0.2	0.5	-0.3	0.6	-0.7	-0.3
Arm fat percentage (right)	0.0	0.1	0.6	-0.3	0.8	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	0.2	-0.0	-0.2	-0.1
Hypertension (Self-reported)	0.0	0.1	0.5	-0.1	0.7	-0.1	-0.3
Basal metabolic rate	0.0	0.2	1.1	0.1	-0.3	-1.0	-0.6
Average weekly beer plus cider intake	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.5	0.5	0.0	-0.1	0.7

Hub : Genes

TSTA3

Models

Trait associations