Hub : Genes

TSTA3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0700 0.0320 3.2e-03 0.015 NA 0.045 NA 0.018 2.1e-02 NA 1.4e-04 NA 1.2e-02
2 GTEx Muscle Skeletal 0.0691 0.0299 2.1e-03 0.003 NA 0.004 NA 0.003 1.4e-01 NA 1.2e-01 NA 1.6e-01
3 METSIM Adipose 0.0528 0.0188 2.1e-04 0.003 0.016 0.005 0.013 0.006 1.2e-01 1.5e-03 4.5e-02 3.4e-03 3.1e-02
4 YFS Blood 0.0609 0.0182 1.2e-06 0.022 0.024 0.031 0.033 0.036 7.3e-08 2.0e-08 1.3e-10 6.2e-11 5.2e-12
5 TCGA Stomach Adenocarcinoma 0.0800 0.0420 3.0e-03 0.003 0.009 0.015 NA 0.007 1.7e-01 6.4e-02 2.7e-02 NA 9.9e-02
6 TCGA Thyroid Carcinoma 0.0340 0.0210 8.8e-03 0.018 0.025 0.032 NA 0.030 6.3e-03 1.7e-03 4.0e-04 NA 6.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.5 0.8 3.9 -0.3 0.0 -2.0 0.0 -0.7 0.7
Bipolar Disorder or Schizophrenia 0.1 0.2 0.6 -0.2 0.0 -0.8 0.0 -0.3 -0.4
Depressed Affect (Nagel 2018) 0.3 0.6 3.3 -1.8 0.0 -0.0 0.0 -0.0 0.4
Depression (Nagel 2018) 0.7 1.1 3.0 -1.4 0.0 -1.2 0.0 1.7 0.4
Intelligence (Savage-Jansen 2018) 0.4 1.3 4.8 1.4 0.0 -2.2 0.0 0.9 0.4
Neuroticism (Nagel 2018) 0.5 1.2 6.1 -2.5 0.0 -1.1 0.0 -0.1 -0.1
Schizophrenia (2018) 0.1 0.2 1.1 -0.1 0.0 0.5 0.0 0.2 -1.0
Schizophrenia vs Biploar Disorder 0.7 1.0 2.8 -1.7 0.0 1.3 0.0 0.1 -1.1
Worry (Nagel 2018) 0.7 1.6 6.6 -2.6 0.0 -1.6 0.0 0.3 -0.5
Alzheimer’s Disease (in mother) 0.3 0.4 1.4 -0.7 0.0 0.3 0.0 -1.2 -0.5
Alzheimer’s Disease (in father) 0.3 0.3 1.4 0.5 0.0 1.2 0.0 0.1 0.3
Alzheimer’s Disease (including proxy) 0.2 0.3 1.4 0.1 0.0 0.3 0.0 -1.2 -0.7
Crohns Disease (2017) 0.3 0.6 2.6 -0.4 0.0 0.8 0.0 -0.2 -1.6
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 -0.3 0.0 0.9 0.0 0.3 -0.8
Ulcerative Colitis (UC) 0.2 0.4 1.7 -0.0 0.0 -0.1 0.0 1.3 0.8
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.9 1.7 6.9 -1.5 0.0 2.6 0.0 -0.8 -0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 5.6 -0.0 0.0 -2.4 0.0 1.2 0.5
Breast Cancer 0.3 0.7 3.8 0.0 0.0 0.3 0.0 0.4 2.0
Ovarian Cancer 0.1 0.2 0.8 0.4 0.0 0.9 0.0 -0.4 -0.0
Prostate Cancer 0.0 0.1 0.2 0.3 0.0 0.2 0.0 0.5 -0.2
Age at First Birth 0.1 0.2 0.8 0.2 0.0 -0.3 0.0 0.9 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.5 1.8 0.5 0.0 1.3 0.0 -0.1 -0.8
Coronary Artery Disease (CAD) 0.2 0.2 0.7 0.0 0.0 0.0 0.0 -0.8 -0.7
Crohns Disease (2012) 0.1 0.2 0.4 -0.7 0.0 0.6 0.0 0.3 -0.3
Mean Putamen Volume 0.4 0.5 2.4 0.4 0.0 1.5 0.0 -0.5 -0.5
Fasting Glucose 0.4 0.5 1.9 0.5 0.0 1.0 0.0 0.1 -1.4
HbA1C 0.1 0.1 0.5 -0.1 0.0 0.4 0.0 -0.3 0.7
HDL Cholesterol 0.3 0.5 2.6 -1.6 0.0 -0.2 0.0 -0.1 -0.5
LDL Cholesterol 0.8 1.3 4.6 2.2 0.0 -1.6 0.0 0.3 0.7
Lupus 0.1 0.1 0.5 0.2 0.0 0.7 0.0 0.1 -0.2
Neuroticism (2016) 1.4 2.1 5.3 -2.3 0.0 -0.6 0.0 1.6 2.0
Primary Biliary Cirrhosis 1.5 2.1 3.5 1.6 0.0 1.9 0.0 -1.8 -1.8
Rheumatoid Arthritis 0.5 0.7 3.2 0.8 0.0 1.8 0.0 0.2 -0.3
Schizophrenia (2014) 0.2 0.4 1.7 -0.6 0.0 0.3 0.0 -0.5 -1.3
Triglycerides 0.3 0.6 2.4 0.3 0.0 0.4 0.0 1.5 0.8
Type 2 Diabetes (T2D) (2012) 1.1 1.3 5.3 1.1 0.0 -0.1 0.0 -1.2 -2.3
Ulcerative Colitis 0.3 0.5 2.1 -0.1 0.0 0.6 0.0 1.5 0.7
Blood Eosinophil Count 0.2 1.5 6.9 2.6 0.0 1.3 0.0 -0.5 0.6
Blood Platelet Count 1.6 18.5 57.6 2.6 0.0 -7.6 0.0 6.2 2.8
Blood Red Count 0.3 3.2 12.1 -2.0 0.0 3.5 0.0 -1.2 -1.1
Blood White Count 0.2 1.6 4.5 -2.1 0.0 0.3 0.0 1.8 1.3
Heel T-Score 0.3 2.6 5.4 1.7 0.0 2.2 0.0 -1.5 -2.3
BMI 0.2 1.3 5.2 -2.3 0.0 1.1 0.0 0.7 0.9
Height 0.1 2.7 11.2 2.0 0.0 -3.3 0.0 0.9 0.2
Waist Hip Ratio (WHR) 0.1 0.6 1.4 -0.6 0.0 0.9 0.0 1.0 -1.2
Systolic Blood Pressure 0.0 0.1 0.6 -0.1 0.0 0.8 0.0 0.4 -0.1
Smoking Status 0.3 0.8 3.4 -1.8 0.0 0.9 0.0 -0.6 0.5
Allergy or Eczema 0.0 0.1 0.4 0.2 0.0 0.7 0.0 0.4 0.3
Cardiovascular Disease 0.1 0.3 1.5 -0.4 0.0 -0.0 0.0 -0.4 -1.2
Hypothyroidism (self reported) 0.0 0.1 0.4 -0.1 0.0 -0.6 0.0 0.1 0.2
Respiratory disease 0.5 1.1 3.5 0.3 0.0 1.9 0.0 0.9 1.5
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.7 0.4 0.0 -1.6 0.0 -1.0 -1.2
Lung FEV1/FVC ratio 0.2 0.9 3.4 1.8 0.0 -1.2 0.0 0.5 0.5
Lung FVC 0.1 0.6 3.3 0.1 0.0 -0.2 0.0 -0.4 1.8
Neuroticism 0.4 0.9 3.6 -1.9 0.0 -1.3 0.0 -0.1 -0.4
Chronotype (morning person) 0.3 0.8 2.1 1.2 0.0 -0.1 0.0 -1.4 -1.2
Hair Pigment 0.0 0.4 2.1 1.5 0.0 0.0 0.0 -0.3 -0.5
Tanning 0.2 2.1 6.6 -2.6 0.0 1.9 0.0 -1.2 0.9
Hand grip strength (left) 0.2 0.7 2.9 -0.2 0.0 -1.7 0.0 0.5 0.9
Number of treatments/medications taken 0.3 0.6 2.5 -0.7 0.0 -0.8 0.0 1.6 0.3
Average weekly spirits intake 0.9 1.1 3.1 0.4 0.0 -0.9 0.0 1.8 1.5
Sensitivity / hurt feelings 0.5 0.9 4.7 0.4 0.0 -2.2 0.0 0.6 0.2
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 0.7 0.0 -0.4 0.0 1.2 -0.4
Hearing difficulty/problems: Yes 0.3 0.5 2.0 -0.5 0.0 -1.4 0.0 -0.1 0.9
Relative age of first facial hair 1.7 3.5 9.7 -1.9 0.0 3.1 0.0 -2.0 -1.8
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 2.2 0.0 0.0 0.4 0.0 1.5 -0.7
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.1 -1.2 0.0 -1.4 0.0 1.0 1.0
Ever had hysterectomy (womb removed) 0.5 0.6 2.7 -0.6 0.0 1.6 0.0 0.7 -0.2
Systolic blood pressure, automated reading 0.0 0.1 0.6 -0.1 0.0 0.8 0.0 -0.2 0.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 3.2 0.7 0.0 -1.8 0.0 0.7 0.4
Angina 0.4 0.6 1.6 -1.2 0.0 0.7 0.0 1.2 0.0
Medication for hormone replacement therapy 0.9 1.0 2.6 -1.2 0.0 -1.6 0.0 1.0 0.9
Vitamin and mineral supplements 0.3 0.4 1.1 1.1 0.0 -0.7 0.0 -0.8 -0.3
Supplements: Zinc 0.2 0.2 0.7 -0.8 0.0 0.5 0.0 0.0 0.4
Medication: Co-codamol 0.6 0.7 3.1 -0.4 0.0 -0.0 0.0 1.0 1.8
Medication: Metformin 0.4 0.5 1.6 0.6 0.0 -1.3 0.0 -0.4 -1.1
Diabetes (father) 0.3 0.4 1.8 -0.5 0.0 -1.3 0.0 0.3 0.7
Diabetes (mother) 0.4 0.5 2.5 -0.4 0.0 1.6 0.0 -0.7 -0.2
Severe depression (siblings) 0.3 0.4 1.1 1.0 0.0 -0.3 0.0 -0.7 -0.8
Pack years adult smoking proportion 0.1 0.2 0.8 -0.6 0.0 0.1 0.0 -0.0 0.9
Impedance of leg (right) 0.1 0.4 1.2 -0.8 0.0 -0.1 0.0 1.1 0.5
Leg fat-free mass (left) 0.1 0.3 0.8 0.9 0.0 -0.9 0.0 -0.3 -0.3
Trunk fat percentage 0.1 0.3 0.7 -0.8 0.0 0.7 0.0 0.7 0.5
Hand grip strength (right) 0.2 0.6 2.9 -0.5 0.0 -1.7 0.0 -0.7 0.2
Townsend deprivation index at recruitment 0.3 0.4 1.3 -0.9 0.0 0.6 0.0 -1.1 0.4
Current tobacco smoking 0.7 1.1 4.0 -0.8 0.0 2.0 0.0 -1.0 -1.0
Average weekly fortified wine intake 0.9 1.1 3.9 -0.7 0.0 2.0 0.0 -0.9 -1.2
Maternal smoking around birth 0.6 0.9 4.3 -2.1 0.0 -0.9 0.0 -0.5 -0.3
Fed-up feelings 0.2 0.4 1.7 -0.7 0.0 0.6 0.0 -1.3 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.9 -1.4 0.0 -1.2 0.0 1.3 0.7
Relative age voice broke 0.6 0.9 3.2 -1.8 0.0 1.1 0.0 -0.5 -0.7
Taking other prescription medications 0.7 1.1 2.9 -1.7 0.0 -0.8 0.0 0.9 1.4
Age when periods started (menarche) 0.5 1.1 4.2 1.4 0.0 -2.0 0.0 0.4 -0.8
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.2 -1.1 0.0 1.1 0.0 0.4 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 6.7 1.5 0.0 2.5 0.0 -2.1 -2.6
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 4.0 -0.5 0.0 0.6 0.0 0.9 2.0
Qualifications: CSEs or equivalent 0.1 0.2 0.6 -0.3 0.0 -0.2 0.0 -0.5 0.8
Serious illness, injury or assault to yourself 0.6 0.7 2.5 0.5 0.0 -0.7 0.0 1.6 0.9
High blood pressure 0.0 0.1 0.3 -0.2 0.0 0.5 0.0 -0.1 -0.1
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.2 -0.2 0.0 0.2 0.0 -0.4 0.1
Multivitamins +/- minerals 0.1 0.2 0.6 -0.7 0.0 -0.0 0.0 0.6 -0.2
Stomach or abdominal pain in last month 0.7 0.8 2.1 0.3 0.0 1.4 0.0 -1.1 -1.3
Supplements: Glucosamine 0.7 1.0 3.8 -1.4 0.0 -0.2 0.0 0.3 1.9
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.0 -1.3 0.0 1.7 0.0 0.6 0.8
Medication: Atenolol 0.7 0.9 2.3 1.0 0.0 0.9 0.0 -1.1 -1.5
Medication: Levothyroxine sodium 0.3 0.6 3.3 0.2 0.0 -0.3 0.0 1.8 0.0
Sitting height 0.2 1.1 4.6 2.1 0.0 -0.2 0.0 -0.9 -1.1
Chronic bronchitis/emphysema (father) 0.2 0.3 0.7 -0.5 0.0 0.5 0.0 0.8 -0.7
High blood pressure (mother) 1.4 2.0 10.6 3.3 0.0 0.6 0.0 1.1 -0.1
Body mass index (BMI) 0.3 1.1 3.1 -1.8 0.0 1.6 0.0 -0.9 0.4
Impedance of leg (left) 0.0 0.2 0.6 -0.6 0.0 0.7 0.0 0.6 0.3
Leg predicted mass (left) 0.1 0.3 0.8 0.9 0.0 -0.9 0.0 -0.2 -0.3
Trunk fat mass 0.0 0.2 0.6 -0.8 0.0 0.7 0.0 0.3 0.3
Waist circumference 0.1 0.3 0.7 -0.8 0.0 0.6 0.0 -0.7 -0.2
Number of incorrect matches in round 0.9 1.4 6.3 -0.6 0.0 2.5 0.0 -0.4 -1.3
Past tobacco smoking 0.5 0.9 3.0 1.7 0.0 0.5 0.0 -0.0 -1.4
Alcohol usually taken with meals 0.1 0.2 0.9 -0.9 0.0 -0.6 0.0 -0.1 -0.2
Nervous feelings 0.1 0.3 1.2 -1.1 0.0 -0.4 0.0 0.0 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.3 0.4 0.0 -0.9 0.0 1.5 1.4
Hearing difficulty/problems with background noise 0.7 1.1 3.8 0.8 0.0 -2.0 0.0 0.1 1.4
Hair/balding pattern: Pattern 2 1.0 1.3 5.9 -0.6 0.0 0.8 0.0 0.9 2.4
Had menopause 0.2 0.3 1.0 -0.4 0.0 0.7 0.0 -0.4 -1.0
Had other major operations 0.2 0.3 0.9 0.6 0.0 1.0 0.0 0.4 0.1
Forced vital capacity (FVC) 0.1 0.5 2.6 1.6 0.0 -0.4 0.0 -0.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 10.6 -0.0 0.0 2.6 0.0 -3.3 -2.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.1 0.2 0.0 -1.0 0.0 -1.0 0.5
Qualifications: None of the above 0.3 0.6 2.3 -0.4 0.0 1.5 0.0 -1.1 -0.1
Financial difficulties in last 2 years 0.2 0.3 1.1 0.2 0.0 -0.4 0.0 0.8 1.1
Mouth/teeth dental problems 0.1 0.1 0.4 -0.3 0.0 -0.6 0.0 0.2 0.6
Heart attack 0.4 0.5 3.0 -1.7 0.0 0.0 0.0 -0.2 -0.2
Allergy 0.3 0.7 1.9 0.5 0.0 -1.4 0.0 0.9 -1.1
Pain all over the body in last month 2.8 3.0 8.5 -2.9 0.0 -0.7 0.0 2.4 1.7
Diabetes (self-reported) 0.5 0.8 1.6 -0.3 0.0 -1.2 0.0 -1.2 -1.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 3.8 0.7 0.0 1.9 0.0 -0.4 -0.2
Medication: Ramipril 1.4 1.8 3.6 1.9 0.0 1.9 0.0 1.4 -1.3
Medication: Simvastatin 0.2 0.3 0.8 0.8 0.0 -0.4 0.0 0.9 -0.1
Fluid intelligence score 0.7 1.6 5.5 1.2 0.0 -1.5 0.0 2.4 -0.4
Illnesses of siblings 0.2 0.3 1.3 1.1 0.0 0.2 0.0 0.1 -0.7
Neuroticism score 0.4 0.8 3.7 -1.9 0.0 -1.0 0.0 -0.2 -0.1
Weight 0.0 0.2 0.5 -0.3 0.0 0.6 0.0 -0.7 -0.3
Impedance of arm (right) 1.1 5.1 13.7 3.7 0.0 -2.4 0.0 3.3 -0.8
Arm fat percentage (right) 0.0 0.1 0.6 -0.3 0.0 0.8 0.0 0.4 0.2
Trunk fat-free mass 0.1 0.5 1.8 0.3 0.0 -0.5 0.0 -1.3 -0.9
Hip circumference 0.1 0.2 0.7 0.8 0.0 -0.3 0.0 -0.7 0.1
Time employed in main current job 0.6 0.6 3.1 -0.7 0.0 -1.8 0.0 -0.5 0.1
Alcohol intake versus 10 years previously 1.8 2.7 7.5 -2.7 0.0 1.7 0.0 -0.3 2.4
Father’s age at death 0.6 0.8 3.8 -2.0 0.0 -0.3 0.0 0.8 0.7
Worrier / anxious feelings 0.3 0.6 1.3 -1.2 0.0 -0.6 0.0 -0.7 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 2.6 0.3 0.0 -1.6 0.0 1.0 0.9
Falls in the last year 0.3 0.4 2.1 0.0 0.0 0.4 0.0 -1.5 -0.3
Hair/balding pattern: Pattern 3 0.6 0.8 3.1 0.8 0.0 1.1 0.0 0.1 -1.8
Number of live births 0.2 0.3 1.5 0.3 0.0 0.2 0.0 -1.2 -0.3
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 4.7 2.2 0.0 -1.2 0.0 0.0 0.7
Pulse rate 2.1 3.5 10.7 -1.0 0.0 -3.3 0.0 2.6 1.6
Happiness 0.3 0.3 1.1 0.1 0.0 -1.0 0.0 0.4 -0.9
Noisy workplace 0.1 0.2 0.6 -0.8 0.0 -0.0 0.0 -0.6 0.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.6 0.6 0.0 -0.3 0.0 0.4 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.1 0.5 0.0 -0.5 0.0 -1.0 -0.2
Mouth/teeth dental problems: Dentures 0.7 1.2 3.8 -2.0 0.0 -0.5 0.0 0.4 1.8
Asthma 0.6 1.1 3.6 -0.3 0.0 1.9 0.0 0.4 1.7
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 4.8 -2.2 0.0 2.2 0.0 0.8 0.7
Medication: Cholesterol lowering 0.6 0.9 1.9 -0.8 0.0 -1.3 0.0 1.4 1.0
Depression (self-reported) 1.4 1.7 5.1 -1.5 0.0 -2.3 0.0 1.0 1.3
Medication: Lansoprazole 0.4 0.5 1.1 -1.0 0.0 -0.7 0.0 0.6 1.1
Prospective memory result 0.4 0.5 1.5 -1.2 0.0 0.9 0.0 -0.7 -0.2
Lung cancer (father) 0.3 0.4 1.5 -0.1 0.0 0.8 0.0 0.1 1.2
Illnesses of mother 0.7 0.9 4.3 -2.1 0.0 -0.9 0.0 0.5 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.5 1.2 0.0 -1.0 0.0 -0.8 0.9
Pulse wave Arterial Stiffness index 1.0 1.2 3.7 -1.9 0.0 1.4 0.0 -0.4 1.0
Impedance of arm (left) 0.9 4.3 12.1 3.5 0.0 -1.8 0.0 3.2 -0.6
Arm fat mass (right) 0.1 0.2 0.8 -0.9 0.0 0.7 0.0 -0.3 0.2
Trunk predicted mass 0.1 0.4 1.4 0.3 0.0 -0.6 0.0 -1.2 -0.9
Standing height 0.2 2.4 7.9 2.8 0.0 -1.9 0.0 0.5 -1.6
Length of working week for main job 1.3 1.4 4.3 -1.9 0.0 0.1 0.0 0.9 2.1
Exposure to tobacco smoke at home 0.4 0.4 1.5 -0.4 0.0 1.2 0.0 0.9 0.4
Breastfed as a baby 1.8 2.2 9.5 3.1 0.0 -1.6 0.0 0.9 -0.6
Tense / ‘highly strung’ 0.4 0.6 2.5 -1.6 0.0 0.9 0.0 -0.2 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.5 -1.3 0.0 -0.9 0.0 -0.5 1.6
Hair/balding pattern: Pattern 4 1.3 3.2 8.2 -1.2 0.0 -2.5 0.0 1.7 2.9
Birth weight of first child 0.3 0.5 1.5 0.1 0.0 0.9 0.0 -1.2 -0.8
Peak expiratory flow (PEF) 1.0 2.4 9.1 3.0 0.0 -1.6 0.0 -0.9 -1.4
Pulse wave reflection index 1.1 1.4 6.9 -1.1 0.0 2.6 0.0 -0.3 0.0
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.3 0.0 0.4 0.0 0.2 -0.4
Loud music exposure frequency 1.2 1.3 4.7 -1.7 0.0 -0.3 0.0 -2.2 -0.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.1 1.0 0.0 -0.7 0.0 1.0 -1.1
Mouth/teeth dental problems: Bleeding gums 2.7 3.5 9.2 2.0 0.0 2.6 0.0 0.9 -3.0
Blood clot in the leg (DVT) 0.7 0.9 2.4 -0.9 0.0 0.8 0.0 -1.3 1.5
Medication: Paracetamol 0.2 0.3 1.2 -0.4 0.0 -0.4 0.0 0.6 -1.1
Headache pain in last month 0.2 0.3 0.9 -1.0 0.0 -0.8 0.0 0.1 0.1
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 3.4 1.4 0.0 0.5 0.0 -1.8 -1.7
Glaucoma (self-reported) 0.9 1.1 5.4 2.3 0.0 0.3 0.0 1.0 -0.3
Gout (self-reported) 0.6 0.9 3.2 -1.8 0.0 1.2 0.0 0.6 0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.1 0.0 -0.2 0.0 0.5 -0.5
Medication: Amlodipine 0.9 1.3 4.8 0.7 0.0 -1.3 0.0 2.2 -0.9
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.1 -1.4 0.0 0.2 0.0 0.4 1.4
Birth weight 0.3 0.6 3.6 0.3 0.0 -0.4 0.0 0.0 1.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 5.0 -2.2 0.0 0.1 0.0 -0.3 -0.4
High blood pressure (siblings) 0.1 0.2 0.6 -0.8 0.0 0.4 0.0 0.1 0.7
Forced vital capacity (FVC), Best measure 0.1 0.4 1.3 0.8 0.0 0.1 0.0 -1.1 0.5
Body fat percentage 0.2 0.7 2.0 -1.3 0.0 1.4 0.0 0.3 0.6
Leg fat percentage (right) 0.5 1.8 5.1 -2.3 0.0 2.0 0.0 -0.6 1.3
Arm fat-free mass (right) 0.1 0.5 1.9 -1.0 0.0 0.1 0.0 -1.4 -0.1
Exposure to tobacco smoke outside home 0.3 0.4 2.2 -1.5 0.0 0.4 0.0 0.1 0.5
Comparative body size at age 10 0.3 0.8 3.5 -0.7 0.0 0.8 0.0 -1.9 0.6
Number of full brothers 1.6 2.1 9.3 0.5 0.0 3.0 0.0 -1.7 -0.0
Worry too long after embarrassment 1.4 2.3 8.1 -1.0 0.0 -2.9 0.0 2.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.7 -0.8 0.0 0.5 0.0 0.5 -0.3
Wheeze or whistling in the chest in last year 1.2 2.1 10.4 -0.2 0.0 3.2 0.0 -1.2 -0.8
Number of children fathered 1.8 2.0 7.9 1.5 0.0 0.9 0.0 2.8 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.6 -0.4 0.0 0.6 0.0 -1.3 0.0
Age at first live birth 0.5 0.9 2.2 1.4 0.0 -1.5 0.0 0.8 -0.5
Pulse wave peak to peak time 1.0 1.2 4.0 2.0 0.0 -1.5 0.0 0.6 -0.9
Health satisfaction 0.3 0.4 1.0 -0.6 0.0 -1.0 0.0 -0.7 -0.7
Shortness of breath walking on level ground 0.4 0.5 1.3 -1.0 0.0 -0.9 0.0 -1.1 0.4
Qualifications: College or University degree 0.1 0.3 0.9 0.7 0.0 0.2 0.0 -0.1 -1.0
Eye problems/disorders: None of the above 0.4 0.5 1.4 -0.9 0.0 1.2 0.0 -0.8 -0.5
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.3 -1.1 0.0 1.4 0.0 -1.8 -0.9
Emphysema/chronic bronchitis 0.5 0.5 1.7 1.1 0.0 1.3 0.0 -0.5 0.3
Medication for pain relief, constipation, heartburn 0.8 1.4 5.8 2.4 0.0 -1.5 0.0 -0.7 -0.1
Neck or shoulder pain in last month 0.1 0.2 1.0 1.0 0.0 0.4 0.0 0.0 -0.1
Medication: Blood pressure 0.7 1.2 2.8 -1.4 0.0 0.5 0.0 1.5 1.7
Angina (self-reported) 0.5 0.6 1.8 -1.2 0.0 0.7 0.0 1.3 0.1
Migraine (self-reported) 3.1 3.9 8.7 -0.8 0.0 -2.9 0.0 2.3 2.9
Medication: Ibuprofen 1.2 1.4 3.8 -1.9 0.0 1.5 0.0 1.2 0.9
Medication: Allopurinol 0.4 0.5 1.1 -1.1 0.0 1.0 0.0 -0.8 0.4
Medication: Omeprazole 0.2 0.3 1.0 0.2 0.0 0.7 0.0 0.2 -1.0
Medication: Seretide 50 evohaler 0.2 0.2 1.0 -0.5 0.0 0.1 0.0 1.0 0.3
Mean time to correctly identify matches 1.4 2.7 8.6 -2.0 0.0 2.9 0.0 -1.6 -1.1
Heart disease (mother) 0.8 1.0 3.3 0.2 0.0 -1.4 0.0 -0.9 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.8 0.9 0.0 0.0 0.0 0.8 0.5
Whole body fat mass 0.1 0.6 1.9 -1.4 0.0 1.2 0.0 -0.1 0.4
Leg fat mass (right) 0.3 1.0 2.7 -1.6 0.0 1.4 0.0 -0.7 1.0
Arm predicted mass (right) 0.1 0.6 2.5 -1.0 0.0 0.2 0.0 -1.6 -0.3
Pulse rate, automated reading 1.5 4.8 14.3 -2.0 0.0 -3.8 0.0 1.4 2.8
Alcohol intake frequency. 0.2 0.4 1.8 -0.4 0.0 -1.3 0.0 -0.5 -0.3
Comparative height size at age 10 0.3 1.7 3.7 1.9 0.0 -1.6 0.0 1.3 -1.6
Number of full sisters 0.6 0.8 3.0 1.2 0.0 -1.7 0.0 -0.2 0.3
Suffer from ‘nerves’ 0.6 0.9 3.3 -1.8 0.0 -0.7 0.0 0.3 1.2
Overall health rating 0.3 0.7 2.7 -1.6 0.0 0.3 0.0 -1.0 -0.4
Chest pain or discomfort 0.9 1.3 6.3 -0.3 0.0 2.5 0.0 -0.1 -1.2
Had major operations 0.8 0.9 2.7 -1.4 0.0 1.6 0.0 -0.3 -0.8
Age at last live birth 0.1 0.2 0.9 0.1 0.0 -0.9 0.0 -0.2 -0.1
Family relationship satisfaction 0.4 0.5 1.0 -1.0 0.0 -0.7 0.0 0.9 0.7
Leg pain on walking 0.4 0.5 1.9 0.8 0.0 -1.4 0.0 0.7 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 0.2 0.0 -0.0 0.0 -0.2 -0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.5 2.0 1.4 0.0 -0.5 0.0 0.7 0.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.4 -0.5 0.0 0.5 0.0 0.6 0.0
Medication: Aspirin 0.3 0.4 1.0 -1.0 0.0 0.7 0.0 0.5 0.8
Supplements: Vitamin C 1.3 1.5 5.2 -1.4 0.0 -0.8 0.0 1.1 2.3
Knee pain experienced in last month 1.4 2.1 9.4 1.0 0.0 3.1 0.0 -1.0 -1.2
Hypertension (Self-reported) 0.0 0.1 0.5 -0.1 0.0 0.7 0.0 -0.1 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.0 -0.2 0.0 0.7 0.0 -1.3 -1.7
Illnesses of father: Heart disease 0.1 0.1 0.3 0.1 0.0 0.2 0.0 -0.5 0.6
Illnesses of siblings: Diabetes 0.9 1.1 5.2 -0.9 0.0 -2.3 0.0 0.0 0.8
Smoking status: Previous 0.7 1.1 2.8 -1.7 0.0 -1.0 0.0 0.2 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 4.9 2.2 0.0 -1.0 0.0 0.1 -0.6
Whole body fat-free mass 0.1 0.3 1.3 0.4 0.0 -0.5 0.0 -1.1 -0.7
Leg fat-free mass (right) 0.1 0.4 1.5 1.2 0.0 -0.7 0.0 -0.5 -0.6
Arm fat percentage (left) 0.1 0.2 1.0 -0.2 0.0 1.0 0.0 0.3 0.3
Average weekly red wine intake 0.2 0.2 0.7 -0.2 0.0 0.4 0.0 -0.9 -0.7
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.8 -1.1 0.0 -1.3 0.0 -0.6 1.1
Mood swings 0.3 0.6 1.8 -1.3 0.0 0.7 0.0 -1.2 -0.2
Loneliness, isolation 0.4 0.6 1.8 -1.3 0.0 -0.9 0.0 0.5 0.8
Long-standing illness, disability or infirmity 1.0 1.5 4.0 -0.8 0.0 -0.6 0.0 2.0 1.9
Ever had bowel cancer screening 0.9 1.0 3.4 0.4 0.0 -1.5 0.0 1.8 -0.6
Diabetes diagnosed by doctor 0.7 1.1 4.0 0.2 0.0 -1.2 0.0 -1.1 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 1.3 -1.1 0.0 -0.4 0.0 -0.1 0.2
Friendships satisfaction 0.3 0.3 0.8 -0.7 0.0 -0.9 0.0 -0.1 0.8
Qualifications: nursing, teaching 1.0 1.5 6.2 2.5 0.0 -0.7 0.0 -0.7 -1.3
Commuting to job workplace: Walk 0.7 0.7 1.8 0.6 0.0 0.8 0.0 -1.2 -1.3
Eye problems/disorders: Cataract 0.8 0.9 3.9 -2.0 0.0 -0.2 0.0 0.3 1.2
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 3.9 0.7 0.0 -2.0 0.0 -0.5 -1.1
Medication for cholesterol 0.3 0.5 2.3 -0.3 0.0 0.4 0.0 0.8 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.6 -1.0 0.0 0.9 0.0 1.3 0.7
Back pain experienced in last month 0.5 0.7 1.4 1.0 0.0 1.2 0.0 -0.9 1.0
Mineral and other dietary supplements 0.3 0.4 1.2 0.9 0.0 -0.5 0.0 0.0 -1.1
Breast cancer (self-reported) 0.3 0.3 1.2 -0.6 0.0 0.5 0.0 1.1 0.5
Asthma (self-reported) 0.5 0.9 2.8 -0.3 0.0 1.7 0.0 0.5 1.6
Osteoporosis (self-reported) 1.2 1.5 5.9 2.4 0.0 1.2 0.0 -0.4 -1.2
Osteoarthritis (self-reported) 1.9 2.5 6.1 -2.4 0.0 0.8 0.0 1.6 2.5
Medication: Aspirin 0.3 0.4 1.1 -0.7 0.0 0.2 0.0 0.8 1.1
Medication: Gliclazide 1.3 1.5 5.0 1.4 0.0 -2.2 0.0 1.4 -0.4
Illnesses of father: None of the above (group 1) 0.2 0.3 1.0 -0.7 0.0 0.2 0.0 0.2 1.0
Smoking status: Current 0.8 1.3 5.6 -0.3 0.0 2.4 0.0 -0.9 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.7 1.3 0.0 -1.0 0.0 -0.3 0.5
Whole body water mass 0.1 0.3 1.2 0.2 0.0 -0.5 0.0 -1.1 -0.7
Leg predicted mass (right) 0.1 0.4 1.5 1.2 0.0 -0.7 0.0 -0.5 -0.6
Arm fat mass (left) 0.1 0.3 0.9 -0.8 0.0 0.9 0.0 -0.1 0.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.2 -0.9 0.0 0.9 0.0 1.1 0.3
Average weekly champagne plus white wine intake 0.4 0.6 1.6 -0.4 0.0 -1.3 0.0 0.9 1.0
Miserableness 0.1 0.2 0.8 -0.3 0.0 0.9 0.0 -0.3 -0.3
Guilty feelings 0.4 0.7 2.6 -0.8 0.0 0.9 0.0 -1.6 -0.3
Wears glasses or contact lenses 0.6 0.7 3.6 -1.9 0.0 -0.5 0.0 -0.1 0.5
Ever taken oral contraceptive pill 0.8 0.8 3.1 -0.9 0.0 -0.9 0.0 0.6 1.8
Hearing aid user 1.6 1.8 6.0 -1.5 0.0 -2.4 0.0 0.3 1.5
Mother’s age at death 0.4 0.5 1.4 -0.7 0.0 0.1 0.0 -1.1 1.2
Financial situation satisfaction 0.7 0.9 1.9 1.4 0.0 -1.4 0.0 1.2 -0.0
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 0.6 0.0 -0.4 0.0 -0.1 0.4
Commuting to job workplace: Public transport 0.2 0.3 1.4 -1.2 0.0 -0.2 0.0 -0.2 -0.2
Eye problems/disorders: Glaucoma 1.4 1.6 6.9 2.6 0.0 -0.5 0.0 1.6 0.1
Medication: Blood pressure 1.1 2.2 7.8 1.1 0.0 1.2 0.0 -1.6 -2.8
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 -0.6 0.0 0.3 0.0 -0.4 0.3
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.1 -1.4 0.0 0.4 0.0 0.1 1.3
High cholesterol (Self-reported) 0.1 0.2 0.7 -0.1 0.0 -0.9 0.0 0.6 -0.2
Medication: Bendroflumethiazide 0.4 0.6 2.1 -1.0 0.0 1.4 0.0 -0.5 -0.1
Medication: Paracetamol 0.1 0.1 0.3 -0.5 0.0 -0.4 0.0 0.3 -0.3
Medication: Lisinopril 1.1 1.4 4.3 -2.1 0.0 0.1 0.0 -2.1 -0.1
Medication: Atorvastatin 0.5 0.7 2.2 -0.3 0.0 -1.5 0.0 1.3 -0.4
Illnesses of father: High blood pressure 0.5 0.6 2.1 0.2 0.0 -1.4 0.0 1.3 -0.1
Alcohol drinker status: Never 0.4 0.4 1.5 0.0 0.0 -1.2 0.0 0.9 0.5
Ever smoked 0.5 0.8 2.3 -1.5 0.0 -0.6 0.0 -0.5 1.3
Basal metabolic rate 0.0 0.2 1.1 0.1 0.0 -0.3 0.0 -1.0 -0.6
Leg fat percentage (left) 0.6 2.2 7.2 -2.1 0.0 2.7 0.0 -0.9 0.9
Arm fat-free mass (left) 0.1 0.5 2.2 -0.8 0.0 0.3 0.0 -1.5 -0.6
Number of operations (self-reported) 0.6 0.9 3.4 -1.4 0.0 1.8 0.0 0.4 0.3
Average weekly beer plus cider intake 0.0 0.1 0.1 -0.3 0.0 0.3 0.0 -0.3 -0.1
Irritability 0.3 0.5 2.6 -1.6 0.0 -0.2 0.0 0.0 0.5
Risk taking 1.6 2.4 6.6 2.6 0.0 2.4 0.0 0.7 -1.3
Ever had prostate specific antigen (PSA) test 1.1 1.2 4.9 2.2 0.0 -0.6 0.0 -0.2 -1.5
Fractured/broken bones in last 5 years 0.1 0.1 0.4 0.7 0.0 -0.0 0.0 0.1 -0.1
Age started oral contraceptive pill 0.4 0.5 1.8 -0.3 0.0 -0.1 0.0 -1.3 -1.0
Diastolic blood pressure, automated reading 0.0 0.1 0.5 0.5 0.0 0.0 0.0 -0.1 0.7
Ever depressed for a whole week 0.5 0.6 3.3 -0.2 0.0 -1.8 0.0 0.0 0.6
Unable to work because of sickness or disability 0.5 0.7 2.6 -1.6 0.0 0.0 0.0 0.8 1.0
Commuting to job workplace: Cycle 2.0 2.4 10.8 3.3 0.0 -1.3 0.0 1.5 -0.2
Myopia 0.3 0.4 1.3 -0.1 0.0 0.1 0.0 1.1 -1.1
Vascular/heart problems diagnosed by doctor 0.1 0.1 0.5 0.4 0.0 -0.7 0.0 0.1 0.5
Cholesterol lowering medication 0.4 0.6 2.5 1.6 0.0 -0.2 0.0 0.8 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.1 0.2 0.4 -0.6 0.0 0.7 0.0 -0.0 -0.6
Pain experienced in last month 0.2 0.4 1.0 -0.6 0.0 -1.0 0.0 0.5 -0.9
Supplements: Calcium 0.1 0.1 0.3 -0.4 0.0 -0.2 0.0 0.5 -0.6
Basal cell carcinoma (self-reported) 0.6 0.7 2.7 -1.0 0.0 -1.6 0.0 0.7 0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 3.1 -1.8 0.0 -0.3 0.0 0.2 0.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.8 -0.8 0.0 1.2 0.0 -1.1 1.7
Heart disease (siblings) 0.1 0.1 0.7 -0.8 0.0 0.1 0.0 -0.2 0.2
Alcohol drinker status: Previous 0.4 0.5 1.2 1.1 0.0 -1.0 0.0 0.7 0.1
Pack years of smoking 0.1 0.2 0.4 -0.6 0.0 0.4 0.0 -0.4 0.7
Impedance of whole body 0.3 1.3 4.5 1.6 0.0 -0.8 0.0 2.1 -0.1
Leg fat mass (left) 0.3 1.0 2.7 -1.4 0.0 1.6 0.0 -0.8 0.8
Arm predicted mass (left) 0.1 0.6 2.3 -1.0 0.0 0.2 0.0 -1.5 -0.3