TWAS hub - TTC14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1760	0.0390	0.0e+00	0.166	0.174	0.185	0.190	0.193	1.1e-19	1.2e-20	6.1e-22	1.4e-22	5.7e-23
2	GTEx	Adipose Subcutaneous	0.1110	0.0380	8.0e-05	0.117	NA	0.100	NA	0.105	8.8e-10	NA	1.4e-08	NA	6.2e-09
3	GTEx	Esophagus Mucosa	0.0920	0.0360	1.2e-04	0.033	NA	0.021	NA	0.045	2.6e-03	NA	1.4e-02	NA	5.7e-04
4	GTEx	Nerve Tibial	0.1617	0.0515	4.9e-05	0.100	NA	0.118	NA	0.093	1.5e-07	NA	1.1e-08	NA	4.4e-07
5	GTEx	Skin Sun Exposed Lower leg	0.1020	0.0410	2.4e-03	0.031	NA	0.057	NA	0.053	1.2e-03	NA	1.6e-05	NA	3.5e-05
6	METSIM	Adipose	0.0274	0.0146	8.0e-03	0.023	0.005	0.018	0.007	0.016	1.9e-04	5.9e-02	8.8e-04	2.4e-02	1.7e-03
7	YFS	Blood	0.0348	0.0129	1.4e-06	0.030	0.022	0.027	0.025	0.028	4.5e-10	7.2e-08	3.4e-09	1.1e-08	1.5e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Schizophrenia (2018)	7.3	15.1	24.1	-4.2	-4.0	-4.9	-3.4	-1.9	-4.1	-4.0
Schizophrenia (2014)	6.2	13.8	26.4	-3.9	-3.6	-5.1	-3.2	-2.1	-3.7	-3.6
Bipolar Disorder or Schizophrenia	5.3	12.9	22.6	-3.7	-3.5	-4.8	-3.5	-2.3	-3.4	-3.5
Diverticular disease/diverticulitis (self-reported)	4.7	5.5	7.4	-2.3	-2.5	-1.7	-2.5	-2.0	-2.7	-2.5
Fractured/broken bones in last 5 years	4.3	5.5	8.2	-2.5	-2.6	-2.2	-2.0	-0.9	-2.9	-2.6
Supplements: Calcium	3.4	3.7	4.6	-2.0	-2.1	1.2	-1.8	-2.0	-1.9	-2.1
Chronotype (morning person)	3.2	7.4	16.8	-4.1	-3.3	-1.0	-1.8	-0.4	-3.1	-3.3
Time employed in main current job	3.2	3.7	5.9	-1.9	-1.8	-2.4	-1.2	-1.7	-2.3	-1.8
Medication: Paracetamol	3.1	5.2	9.8	3.1	2.2	1.8	2.6	1.7	2.0	2.2
Worry too long after embarrassment	3.1	5.2	9.1	3.0	2.4	0.5	3.0	1.3	2.3	2.4
Mineral and other dietary supplements	3.0	4.0	5.7	2.4	2.2	0.9	2.2	0.9	2.3	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	5.6	2.4	2.1	1.2	2.1	1.0	2.1	2.1
Depression (Nagel 2018)	2.6	3.9	5.0	2.1	2.1	1.2	2.2	1.6	2.2	2.1
Ever had hysterectomy (womb removed)	2.5	2.8	4.2	2.1	2.0	0.6	1.6	1.0	1.9	2.0
Medication: Paracetamol	2.5	3.9	7.7	2.8	1.9	1.8	2.3	1.2	1.6	1.9
Schizophrenia vs Biploar Disorder	2.4	3.2	5.8	-1.7	-2.1	-1.8	-1.1	-0.5	-2.4	-2.1
Supplements: Glucosamine	2.4	3.1	4.7	-2.2	-2.1	1.0	-1.4	-0.8	-2.2	-2.1
Health satisfaction	2.3	3.1	4.7	-1.7	-2.0	0.5	-1.4	-1.8	-2.2	-2.0
Friendships satisfaction	2.3	2.8	3.6	-1.5	-1.8	-1.1	-1.9	-1.9	-1.7	-1.8
Hearing difficulty/problems: Yes	2.2	3.3	5.3	2.3	2.0	2.1	1.1	0.5	2.0	2.0
Medication for pain relief, constipation, heartburn	2.2	3.7	7.0	-2.6	-2.0	1.6	-1.8	-1.5	-1.6	-2.0
Long-standing illness, disability or infirmity	2.2	3.3	6.6	-1.8	-1.7	-2.6	-2.2	-0.1	-1.7	-1.7
Reaction Time	2.1	4.1	14.0	-2.1	-1.4	-3.7	-1.5	-1.1	-1.6	-1.4
Pulse rate	2.1	3.5	10.3	-1.7	-1.8	-3.2	-1.5	-0.4	-1.7	-1.8
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	6.8	-2.2	-2.1	0.5	-2.6	-0.7	-1.6	-2.1
Fed-up feelings	2.0	3.7	7.8	2.0	1.7	2.8	2.2	0.7	1.7	1.7
Number of children fathered	2.0	2.3	3.2	1.8	1.7	0.9	1.1	1.7	1.7	1.7
Financial situation satisfaction	2.0	2.5	5.7	-1.1	-1.5	1.6	-0.8	-2.4	-1.6	-1.5
Ovarian Cancer	1.9	2.5	3.9	1.6	2.0	1.1	0.8	1.1	2.0	2.0
Average weekly fortified wine intake	1.9	2.3	4.0	1.8	1.6	2.0	0.5	0.3	1.8	1.6
Pain all over the body in last month	1.9	2.0	2.8	1.6	1.7	1.4	0.8	-1.0	1.5	1.7
Multivitamins +/- minerals	1.8	2.2	4.5	-1.8	-1.2	0.7	-1.9	-2.1	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	5.3	2.3	1.8	1.6	1.4	0.4	1.7	1.8
Medication: Amlodipine	1.8	2.5	5.6	-1.5	-1.4	-0.6	-2.4	-2.0	-1.3	-1.4
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.1	-1.4	-1.7	-1.7	-2.0	-0.5	-1.1	-1.7
Average weekly beer plus cider intake	1.8	2.5	4.8	2.2	1.8	-1.4	1.6	0.8	1.4	1.8
Alcohol usually taken with meals	1.7	2.7	5.0	-2.2	-1.9	-0.2	-1.6	-0.4	-2.0	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	2.9	1.6	1.4	1.5	1.7	0.4	1.5	1.4
Lung FEV1/FVC ratio	1.6	8.3	14.5	2.9	2.9	1.9	3.8	2.8	2.7	2.9
Vitamin and mineral supplements	1.6	2.2	4.8	1.3	1.0	-1.3	2.1	2.2	0.9	1.0
Depression (self-reported)	1.6	1.9	2.6	1.5	1.5	0.2	1.5	1.6	1.4	1.5
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.1	1.8	1.6	0.4	1.3	1.1	1.6	1.6
Mood swings	1.6	2.8	5.2	1.9	1.6	2.3	2.0	0.4	1.3	1.6
Osteoporosis (self-reported)	1.6	1.9	2.5	-1.6	-1.4	-1.5	-1.5	0.3	-1.5	-1.4
Alzheimer’s Disease (in mother)	1.5	1.8	2.5	-0.8	-1.3	-1.5	-1.6	-1.2	-1.5	-1.3
Exposure to tobacco smoke outside home	1.5	2.0	5.7	1.1	1.2	-0.4	2.4	1.8	0.8	1.2
Irritability	1.5	2.6	5.0	2.2	1.4	1.6	1.6	1.8	1.1	1.4
Frequency of depressed mood in last 2 weeks	1.4	1.9	3.1	1.8	1.3	1.8	1.3	0.1	1.4	1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.9	-1.2	-1.0	-1.3	-1.7	-2.0	-1.0	-1.0
High blood pressure (mother)	1.4	1.9	2.6	1.6	1.4	1.0	0.9	1.6	1.6	1.4
Had other major operations	1.4	1.7	4.7	-0.9	-1.0	2.2	-1.7	-0.9	-0.8	-1.0
Exposure to tobacco smoke at home	1.4	1.6	3.7	-0.9	-1.1	-1.9	0.1	-1.4	-1.5	-1.1
Pulse rate, automated reading	1.4	4.5	7.9	-2.2	-2.2	-2.8	-2.4	0.5	-1.8	-2.2
Pain experienced in last month	1.4	2.4	5.5	-2.3	-1.9	0.4	-1.3	-0.2	-1.4	-1.9
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	5.2	-0.3	-0.9	-2.3	-0.7	-1.4	-1.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	9.6	-0.0	-0.1	-3.1	-0.1	1.5	-0.3	-0.1
Myopia	1.3	1.8	2.9	1.7	1.2	-1.2	1.5	1.7	0.8	1.2
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.5	-1.8	-1.9	1.2	-2.3	-0.4	-1.7	-1.9
Body Mass Index (BMI) (2010)	1.2	1.6	6.0	1.3	0.8	2.5	1.0	-0.7	0.8	0.8
Hair/balding pattern: Pattern 3	1.2	1.8	3.1	1.0	1.3	0.4	1.7	1.8	1.3	1.3
Number of live births	1.2	1.7	10.4	-0.5	-0.4	-3.2	0.2	0.4	-0.7	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	4.4	-0.7	-0.9	-2.1	-0.9	1.1	-0.9	-0.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	5.2	2.3	1.4	-0.4	0.7	0.3	1.2	1.4
Medication: Ibuprofen	1.2	1.4	7.3	0.1	-0.0	-2.7	0.1	1.6	-0.3	-0.0
Illnesses of father: Heart disease	1.2	1.6	2.4	-1.0	-1.1	-1.4	-1.6	-1.4	-1.2	-1.1
Loneliness, isolation	1.2	1.6	2.9	1.7	1.5	0.6	1.4	0.1	1.3	1.5
Medication: Bendroflumethiazide	1.2	1.8	4.2	-1.0	-1.1	-1.4	-2.1	-1.4	-1.0	-1.1
HDL Cholesterol	1.1	1.9	3.5	1.3	1.7	0.4	1.4	0.6	1.9	1.7
Primary Biliary Cirrhosis	1.1	1.5	3.0	-1.7	-1.4	-0.9	-1.2	0.2	-1.2	-1.4
Rheumatoid Arthritis	1.1	1.5	5.3	1.2	1.0	0.1	1.2	2.3	1.0	0.9
Age when periods started (menarche)	1.1	2.6	4.0	1.6	1.9	-1.0	1.2	2.0	1.6	1.9
Medication: Lansoprazole	1.1	1.2	2.0	1.4	1.2	1.0	0.9	0.6	1.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.2	-1.2	-1.2	-1.0	-1.5	-0.0	-1.1	-1.2
Mean time to correctly identify matches	1.1	2.1	8.6	-1.7	-0.7	-2.9	-1.1	-0.4	-0.9	-0.7
Depressed Affect (Nagel 2018)	1.0	2.1	5.0	1.3	1.3	2.2	1.8	0.1	1.3	1.3
Neuroticism (Nagel 2018)	1.0	2.2	3.5	1.8	1.4	1.9	1.7	0.4	1.4	1.4
Smoking Status	1.0	2.4	6.6	-0.7	-1.2	2.2	-0.9	-2.6	-1.0	-1.2
Length of working week for main job	1.0	1.1	3.7	0.8	0.6	1.5	0.3	1.9	0.5	0.6
Tense / ‘highly strung’	1.0	1.7	3.1	-1.0	-1.4	-1.4	-1.1	-0.7	-1.8	-1.4
Hair/balding pattern: Pattern 4	1.0	2.4	5.0	-1.7	-1.5	-0.4	-2.2	-1.2	-1.5	-1.5
Gout (self-reported)	1.0	1.4	3.5	1.1	1.0	0.9	1.0	1.9	1.1	1.0
Number of full brothers	1.0	1.2	4.4	1.0	0.9	2.1	0.9	-0.0	0.8	0.9
Illnesses of siblings: Diabetes	1.0	1.2	1.8	-1.0	-1.1	-1.2	-0.5	-1.4	-1.2	-1.1
Wears glasses or contact lenses	1.0	1.2	7.5	0.3	0.1	2.7	0.7	0.0	0.0	0.1
Age started oral contraceptive pill	1.0	1.3	3.6	-1.9	-1.2	-0.8	-0.9	-0.1	-1.1	-1.2
Alzheimer’s Disease (including proxy)	0.9	1.2	2.6	-0.9	-1.3	-0.7	-1.0	-0.6	-1.6	-1.3
Bipolar Disorder (2011)	0.9	0.8	1.7	-1.2	-0.5	-1.1	-1.3	-0.9	-0.5	-0.5
HbA1C	0.9	1.0	1.6	-0.8	-1.0	1.0	-0.1	-1.3	-1.2	-1.0
Systolic blood pressure, automated reading	0.9	2.5	11.2	-1.1	-1.3	-3.3	-0.6	0.0	-1.2	-1.3
Stomach or abdominal pain in last month	0.9	1.1	3.0	-0.8	-0.9	-1.7	-0.9	-0.7	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.9	1.6	8.5	-0.0	-0.4	1.4	-0.2	-2.9	-0.6	-0.4
Pulse wave Arterial Stiffness index	0.9	1.1	2.1	-0.7	-0.9	-1.5	-0.2	-1.2	-1.4	-0.9
Peak expiratory flow (PEF)	0.9	2.0	4.5	1.1	0.9	1.5	1.9	2.1	1.1	0.9
Pulse wave reflection index	0.9	1.1	2.1	1.5	1.0	0.9	1.3	0.2	0.9	1.1
Knee pain experienced in last month	0.9	1.4	2.8	1.1	0.9	-0.8	1.7	1.7	0.7	0.9
Smoking status: Previous	0.9	1.4	7.1	0.2	-0.5	2.7	-0.1	-1.4	-0.4	-0.5
Miserableness	0.9	1.5	2.8	1.7	1.2	1.5	1.2	-0.4	1.1	1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.5	-1.0	-1.0	-1.3	-1.6	-0.4	-1.1	-1.0
Medication: Atorvastatin	0.9	1.1	2.4	1.5	1.2	0.0	0.5	0.8	1.3	1.2
Number of operations (self-reported)	0.9	1.3	7.9	0.4	0.5	2.8	-0.3	0.1	0.5	0.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.2	-0.8	-0.8	-0.7	-1.2	-1.5	-1.0	-0.8
Commuting to job workplace: Cycle	0.9	1.1	2.3	-0.9	-0.9	1.4	-1.5	-0.7	-0.9	-0.9
Pack years of smoking	0.9	1.3	2.1	-1.1	-1.3	-0.9	-0.8	-1.0	-1.5	-1.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	5.4	-1.1	-1.6	2.3	-1.8	-0.3	-1.4	-1.6
LDL Cholesterol	0.8	1.2	5.2	-0.9	-0.9	-2.3	-0.3	-0.2	-0.8	-0.9
Neuroticism (2016)	0.8	1.2	4.2	1.0	0.7	2.0	1.3	-0.1	0.6	0.7
Blood Red Count	0.8	7.9	11.9	3.3	3.2	1.1	2.4	2.3	3.5	3.2
Hand grip strength (left)	0.8	2.2	6.2	1.1	1.2	2.5	0.6	1.4	1.7	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	11.3	0.8	0.4	3.4	0.7	-0.5	0.6	0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.0	-1.2	-1.1	-0.1	-0.0	-0.7	-1.4	-1.1
High blood pressure	0.8	2.4	5.7	-1.4	-1.2	-2.4	-2.1	-0.6	-1.1	-1.2
Falls in the last year	0.8	1.0	2.1	-0.8	-1.1	-0.2	-1.0	-0.9	-1.4	-1.1
Glaucoma (self-reported)	0.8	0.9	2.1	0.6	0.9	0.7	-0.9	-0.8	1.5	0.9
Medication: Seretide 50 evohaler	0.8	1.0	3.9	1.4	0.5	-0.0	0.6	2.0	0.3	0.5
Family relationship satisfaction	0.8	1.0	4.5	-0.1	-0.3	2.1	-0.1	-1.6	-0.1	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.3	-0.3	-0.4	1.2	-1.0	-1.8	-0.4	-0.5
Hearing aid user	0.8	0.9	2.5	-0.5	-0.6	1.6	-0.9	-1.2	-0.5	-0.6
Systolic Blood Pressure	0.7	3.6	22.2	-0.8	-0.7	-4.7	-0.7	1.0	-0.5	-0.7
Medication for hormone replacement therapy	0.7	0.8	2.3	1.5	1.0	-0.1	0.2	-0.6	0.8	1.1
Diabetes (mother)	0.7	0.9	3.6	0.8	0.7	0.3	0.5	1.9	0.9	0.7
Severe depression (siblings)	0.7	0.7	2.2	1.5	0.8	-0.1	1.0	0.8	0.5	0.8
Pack years adult smoking proportion	0.7	1.1	1.9	-0.8	-1.1	-1.4	-0.6	-0.5	-1.3	-1.1
Fluid intelligence score	0.7	1.6	2.4	-1.1	-1.3	1.5	-1.5	-0.4	-1.1	-1.3
Father’s age at death	0.7	0.9	4.1	0.3	0.5	2.0	1.1	0.5	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.2	1.4	1.2	-0.6	1.4	2.5	1.2	1.2
Pulse wave peak to peak time	0.7	0.8	2.0	0.3	0.6	1.4	-0.0	1.3	1.1	0.6
Leg pain on walking	0.7	0.9	1.5	-1.2	-1.2	-0.4	-0.6	-0.4	-1.2	-1.2
Medication: Blood pressure	0.7	1.4	3.5	-0.9	-0.7	-1.9	-1.7	-1.0	-0.7	-0.7
Unable to work because of sickness or disability	0.7	0.9	1.3	1.1	1.0	0.8	0.9	0.6	1.0	1.0
Bipolar Disorder (2018)	0.6	1.0	2.2	-0.7	-0.6	-1.5	-1.3	-1.3	-0.4	-0.6
Triglycerides	0.6	1.0	1.6	-0.8	-1.1	0.0	-1.2	-0.9	-1.3	-1.1
BMI	0.6	3.3	18.1	-0.1	-0.4	4.3	0.4	-2.1	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.2	-1.1	-0.6	0.4	-0.2	-1.5	-0.4	-0.6
Townsend deprivation index at recruitment	0.6	0.8	3.3	-0.5	-0.5	-1.1	-0.2	-1.8	-0.6	-0.5
Qualifications: CSEs or equivalent	0.6	0.7	1.9	0.8	0.9	0.2	1.4	0.1	1.0	0.9
Financial difficulties in last 2 years	0.6	0.9	1.8	1.3	1.1	-0.4	1.0	0.5	0.8	1.1
Heart attack	0.6	0.8	2.1	-0.2	0.0	1.4	-1.2	-1.4	0.2	0.0
Impedance of arm (right)	0.6	2.9	7.6	1.7	1.4	-2.8	1.3	1.8	1.1	1.4
Worrier / anxious feelings	0.6	1.1	4.8	0.6	0.8	2.2	-0.1	-1.0	0.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	7.8	1.2	1.0	0.3	1.2	2.8	1.1	1.0
Happiness	0.6	0.7	3.4	0.1	-0.1	1.8	-0.1	-1.2	0.2	-0.1
Prospective memory result	0.6	0.7	4.8	-0.0	-0.1	-2.2	0.3	0.1	-0.6	-0.1
Illnesses of mother	0.6	0.7	1.7	-1.1	-0.5	1.3	-0.1	-1.3	-0.4	-0.5
Headache pain in last month	0.6	1.0	1.8	1.3	1.1	-1.3	0.4	0.7	0.8	1.1
Shortness of breath walking on level ground	0.6	0.7	1.0	1.0	0.8	0.1	0.9	0.9	0.9	0.8
Number of full sisters	0.6	0.7	3.2	0.9	0.3	-1.8	0.8	0.1	0.1	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	4.4	-0.0	-0.1	2.1	-0.2	0.1	-0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.8	-0.8	-1.0	-0.4	-1.3	-1.2	-1.1	-1.0
Medication for cholesterol	0.6	1.0	2.3	0.5	0.3	1.5	1.5	1.4	0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	1.1	0.7	0.1	1.5	-0.2	0.5	0.7
Back pain experienced in last month	0.6	0.9	2.2	1.5	1.2	0.4	0.7	0.0	0.8	1.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	0.6	1.0	0.8	-0.1	0.1	1.4	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	-0.1	0.1	1.5	-1.1	-1.5	0.2	0.1
Age at First Birth	0.5	0.7	1.0	-0.9	-1.0	1.0	0.1	0.1	-1.0	-1.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	-0.3	-0.6	-0.2	-0.8	-1.3	-1.0	-0.6
Respiratory disease	0.5	1.2	1.9	1.2	1.3	0.4	0.4	1.2	1.4	1.3
Neuroticism	0.5	1.3	2.6	1.5	1.0	1.6	1.1	0.1	0.9	1.0
Supplements: Zinc	0.5	0.5	1.5	-0.5	-0.7	-0.6	-1.2	0.2	-0.7	-0.7
Hand grip strength (right)	0.5	1.3	2.7	0.9	1.1	0.9	0.4	1.7	1.4	1.1
Relative age voice broke	0.5	0.8	2.3	0.9	0.7	1.5	0.4	-0.9	0.8	0.7
Past tobacco smoking	0.5	1.0	5.2	-0.6	0.1	-2.3	-0.2	1.1	0.1	0.1
Nervous feelings	0.5	1.0	4.9	-0.1	-0.7	-2.2	-0.4	-0.4	-0.9	-0.7
Neuroticism score	0.5	1.1	2.3	1.5	0.9	1.3	1.1	-0.6	0.7	0.9
Alcohol intake versus 10 years previously	0.5	0.8	2.6	-0.8	-0.7	1.0	-0.1	-1.6	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	-0.7	-1.1	-0.0	-1.8	-0.2	-1.0	-1.1
Impedance of arm (left)	0.5	2.2	7.3	1.4	1.2	-2.7	1.0	1.4	0.8	1.2
Breastfed as a baby	0.5	0.6	1.2	-0.7	-0.7	0.2	-1.0	-1.1	-0.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.4	0.4	0.0	-0.5	-1.1	-1.8	-0.1	0.0
Loud music exposure frequency	0.5	0.6	2.6	0.5	0.2	0.6	1.0	-1.6	0.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.6	-0.3	-1.2	0.7	-0.9	-0.8	-1.1	-1.2
Birth weight	0.5	1.1	2.0	-0.5	-1.2	0.9	-0.6	-0.9	-1.4	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.7	0.9	0.6	0.8	0.0	-1.3	0.7	0.6
Heart disease (mother)	0.5	0.6	2.3	0.9	0.6	-0.2	0.2	1.5	0.4	0.6
Average weekly red wine intake	0.5	0.8	1.2	-1.0	-1.0	-0.6	-0.9	-0.1	-1.1	-1.0
Diastolic blood pressure, automated reading	0.5	1.6	6.6	-0.9	-1.1	-2.6	-0.9	0.5	-0.9	-1.1
Cholesterol lowering medication	0.5	0.7	3.1	-0.3	0.2	-1.8	-1.1	-0.6	0.4	0.2
Alcohol drinker status: Previous	0.5	0.5	1.9	-0.4	-0.8	0.1	0.1	-1.4	-0.6	-0.8
Mean Putamen Volume	0.4	0.4	0.6	-0.8	-0.7	0.2	-0.6	-0.7	-0.6	-0.7
Sensitivity / hurt feelings	0.4	0.8	2.6	1.0	0.7	1.6	0.2	0.0	0.9	0.7
Angina	0.4	0.5	1.1	0.7	0.9	-0.8	-0.1	0.3	1.0	0.9
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-0.8	-0.3	1.2	-0.9	-0.4	-0.3	-0.3
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.6	0.9	0.2	0.5	0.9	0.8	0.9
Body mass index (BMI)	0.4	1.6	8.9	0.4	0.1	3.0	0.7	-1.3	0.4	0.1
Qualifications: None of the above	0.4	0.8	3.8	0.9	0.4	-0.4	0.8	-1.9	-0.1	0.4
Mouth/teeth dental problems	0.4	0.6	2.7	-1.2	-0.3	0.1	-0.2	1.6	-0.0	-0.3
Noisy workplace	0.4	0.5	1.1	1.0	0.8	0.3	0.8	0.5	0.5	0.7
High blood pressure (siblings)	0.4	0.6	3.4	-0.3	-0.3	-1.8	-0.4	0.3	-0.2	-0.3
Leg fat percentage (right)	0.4	1.6	7.7	0.6	0.5	2.8	0.8	-0.9	0.9	0.5
Qualifications: College or University degree	0.4	1.3	5.8	-0.9	-0.9	0.3	-2.4	0.2	-0.6	-0.9
Neck or shoulder pain in last month	0.4	0.6	2.9	0.0	-0.4	-0.3	0.1	-1.7	-0.8	-0.4
Medication: Omeprazole	0.4	0.4	1.2	1.1	0.7	-0.2	0.5	-0.7	0.3	0.7
Leg fat mass (right)	0.4	1.6	9.9	0.2	-0.0	3.1	0.3	-1.2	0.4	-0.0
Age at last live birth	0.4	0.5	1.4	-0.9	-0.6	-1.2	-0.5	-0.1	-0.8	-0.6
Supplements: Vitamin C	0.4	0.5	1.1	-0.4	-0.7	0.6	-1.1	-0.7	-0.6	-0.7
Hypertension (Self-reported)	0.4	1.2	5.6	-0.6	-0.3	-2.4	-1.4	-0.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.1	1.1	0.6	0.4	-0.3	-0.7	0.6	0.6
Commuting to job workplace: Walk	0.4	0.4	1.6	0.3	-0.1	1.3	-0.2	-1.2	-0.0	-0.1
Eye problems/disorders: Cataract	0.4	0.5	1.5	-0.3	0.2	-1.2	-0.5	1.0	0.6	0.2
Number of self-reported non-cancer illnesses	0.4	0.7	3.4	0.1	0.3	-1.8	-0.5	-1.0	0.2	0.3
Average weekly champagne plus white wine intake	0.4	0.5	1.3	-1.1	-0.6	1.1	0.2	-0.1	-0.6	-0.6
Guilty feelings	0.4	0.6	1.5	0.8	0.6	0.9	0.4	-1.2	0.7	0.6
Mother’s age at death	0.4	0.5	3.2	0.0	0.1	1.8	-0.2	-0.3	-0.0	0.1
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.4	-0.7	-0.3	-1.1	-0.8	-0.6	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.9	0.4	-0.2	-0.6	0.9	1.4	-0.7	-0.2
Medication: Lisinopril	0.4	0.5	2.7	0.1	0.4	-1.6	-0.2	0.6	0.5	0.4
Leg fat percentage (left)	0.4	1.4	5.7	0.7	0.6	2.4	1.0	-0.9	0.9	0.6
Arm fat-free mass (left)	0.4	1.9	5.0	-1.5	-1.3	2.2	-1.1	-0.8	-0.9	-1.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.4	0.8	0.5	1.9	1.6	0.1	0.5	0.5
Leg fat mass (left)	0.4	1.4	8.4	0.2	-0.0	2.9	0.4	-1.2	0.3	-0.0
Arm predicted mass (left)	0.4	1.8	5.7	-1.3	-1.2	2.4	-0.9	-0.8	-0.9	-1.2
Alzheimer’s Disease (in father)	0.3	0.3	1.3	0.1	-0.2	1.1	0.3	0.6	-0.3	-0.2
Prostate Cancer	0.3	0.4	1.3	-0.9	-0.3	1.2	-0.2	-0.8	0.1	-0.3
Cardiovascular Disease	0.3	0.8	4.4	-0.1	0.2	-2.1	-0.4	1.0	0.5	0.2
Number of treatments/medications taken	0.3	0.5	1.5	0.3	0.6	-1.2	-0.7	-0.1	0.5	0.6
Diabetes (father)	0.3	0.3	0.6	-0.6	-0.6	0.6	-0.5	-0.8	-0.4	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	0.6	0.6	-0.2	1.1	0.2	0.8	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.9	0.3	-0.2	-1.7	-0.5	0.8	-0.2	-0.2
Medication: Atenolol	0.3	0.4	1.0	0.4	0.7	1.0	0.1	-0.7	0.6	0.7
Medication: Levothyroxine sodium	0.3	0.5	2.3	0.0	0.3	-1.5	-0.4	-0.9	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	4.7	0.1	0.0	2.2	0.3	-0.4	0.2	0.0
Arm fat percentage (right)	0.3	1.1	3.3	1.1	0.6	1.8	1.3	-0.6	0.8	0.6
Hip circumference	0.3	1.4	5.2	-0.4	-0.7	2.3	0.0	-1.7	-0.6	-0.7
Lung cancer (father)	0.3	0.3	1.9	-0.2	-0.0	-1.4	0.3	-0.1	0.0	-0.0
Arm fat mass (right)	0.3	1.0	5.5	0.4	0.1	2.3	0.6	-1.1	0.3	0.1
Birth weight of first child	0.3	0.5	2.7	-0.3	-0.3	-0.7	-0.1	1.6	-0.4	-0.3
Body fat percentage	0.3	1.1	4.4	0.9	0.6	2.1	0.9	-0.8	0.7	0.6
Arm fat-free mass (right)	0.3	1.5	5.4	-1.2	-1.0	2.3	-0.8	-0.7	-0.7	-1.0
Comparative body size at age 10	0.3	0.8	3.8	0.1	-0.5	2.0	0.8	0.6	-0.7	-0.5
Age at first live birth	0.3	0.6	1.5	-1.1	-0.5	1.2	-0.5	-0.0	-0.6	-0.5
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.9	0.1	-0.8	0.7	0.3	-0.5	0.1
Medication: Blood pressure	0.3	0.6	2.2	-0.2	0.8	-1.5	0.1	0.4	0.6	0.8
Angina (self-reported)	0.3	0.4	1.7	0.2	0.5	-1.3	-0.4	-0.1	0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.8	-0.1	-0.4	1.4	-0.7	-0.5	-0.0	-0.4
Whole body fat mass	0.3	1.1	6.5	0.4	0.2	2.5	0.7	-0.8	0.4	0.2
Arm predicted mass (right)	0.3	1.7	5.8	-1.3	-1.0	2.4	-1.0	-0.8	-0.7	-1.0
Alcohol intake frequency.	0.3	0.7	2.6	0.7	0.0	1.1	0.8	-1.6	0.1	0.0
Had major operations	0.3	0.4	2.4	-0.4	0.1	1.5	0.3	-0.2	0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.8	0.1	0.3	-0.6	0.5	1.3	0.3	0.3
Arm fat percentage (left)	0.3	1.3	3.8	1.1	0.7	1.9	1.3	-0.6	0.9	0.7
Qualifications: nursing, teaching	0.3	0.4	1.1	-0.6	-0.5	-1.0	-0.9	0.5	-0.4	-0.5
Asthma (self-reported)	0.3	0.6	1.3	0.6	0.7	1.0	-0.5	0.6	1.2	0.7
Osteoarthritis (self-reported)	0.3	0.4	1.9	0.4	0.2	-0.5	0.8	1.4	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.1	0.5	0.6	-0.4	0.6	1.8	0.5	0.6
Arm fat mass (left)	0.3	1.1	6.0	0.2	0.0	2.5	0.5	-1.0	0.2	0.0
Ever taken oral contraceptive pill	0.3	0.3	1.3	0.1	0.2	-0.3	0.7	1.1	0.3	0.2
Illnesses of father: High blood pressure	0.3	0.4	2.2	-0.1	-0.0	-0.4	0.2	1.5	-0.3	-0.1
Ever smoked	0.3	0.6	2.8	0.6	0.3	1.7	-0.1	-0.6	0.5	0.4
Risk taking	0.3	0.5	0.8	-0.4	-0.7	0.9	-0.8	-0.2	-0.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	0.8	0.4	-0.8	0.6	-0.5	-0.0	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	-0.6	-0.4	-1.0	-0.8	-0.1	-0.2	-0.4
Heart disease (siblings)	0.3	0.3	0.8	0.9	0.6	-0.6	0.2	-0.0	0.5	0.6
Impedance of whole body	0.3	1.3	5.2	0.9	0.9	-2.3	0.4	1.0	0.6	0.9
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	0.2	0.7	-0.5	-0.2	1.1	0.8	0.7
Ulcerative Colitis (UC)	0.2	0.4	1.1	0.3	0.5	-1.0	0.1	1.1	0.4	0.5
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.3	0.1	-0.7	0.6	0.1	-0.5	0.1
Crohns Disease (2012)	0.2	0.4	1.3	0.5	0.5	1.1	0.4	0.5	0.4	0.5
Blood Eosinophil Count	0.2	1.4	2.7	1.4	0.9	1.6	0.7	1.5	1.0	0.9
Heel T-Score	0.2	1.4	7.8	0.3	0.4	2.8	1.0	0.3	0.6	0.4
Waist Hip Ratio (WHR)	0.2	0.8	3.3	0.6	0.6	-1.8	0.3	-0.4	0.8	0.6
Allergy or Eczema	0.2	0.6	2.8	0.4	0.1	-1.7	0.1	1.1	-0.2	0.1
Hypothyroidism (self reported)	0.2	0.5	1.8	0.3	-0.1	-1.3	0.2	-1.4	-0.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.2	-0.7	-0.4	0.1	-0.1	1.1	-0.1	-0.4
Impedance of leg (right)	0.2	1.0	1.6	0.8	1.2	-0.5	0.3	1.1	1.3	1.2
Trunk fat percentage	0.2	0.7	2.3	0.9	0.5	1.5	1.0	-0.5	0.6	0.5
Taking other prescription medications	0.2	0.4	1.5	0.1	0.0	-1.2	-1.0	-0.0	0.1	0.0
Impedance of leg (left)	0.2	1.2	1.5	1.0	1.2	-1.2	0.6	1.0	1.2	1.2
Trunk fat mass	0.2	0.7	4.1	0.3	0.1	2.0	0.5	-0.6	0.3	0.1
Waist circumference	0.2	0.8	2.9	-0.2	-0.4	1.7	0.0	-1.5	-0.0	-0.4
Number of incorrect matches in round	0.2	0.4	0.7	0.3	0.8	0.6	0.1	0.5	0.8	0.8
Hearing difficulty/problems with background noise	0.2	0.3	1.0	1.0	0.4	-0.5	-0.1	0.3	0.4	0.4
Had menopause	0.2	0.2	0.4	0.6	0.6	-0.2	0.5	0.4	0.3	0.6
Illnesses of siblings	0.2	0.3	1.1	-0.0	0.2	1.1	0.4	0.7	0.2	0.2
Weight	0.2	1.1	6.2	-0.4	-0.5	2.5	-0.0	-1.0	-0.1	-0.5
Trunk fat-free mass	0.2	1.2	4.1	-1.2	-0.9	2.0	-0.7	-0.1	-0.5	-0.9
Asthma	0.2	0.4	1.2	0.1	0.3	1.1	-0.7	0.3	0.8	0.3
Medication: Cholesterol lowering	0.2	0.3	0.6	-0.3	0.7	0.2	0.2	0.3	0.7	0.7
Trunk predicted mass	0.2	1.3	3.9	-1.3	-1.0	2.0	-0.8	-0.1	-0.6	-1.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.7	-0.1	-0.3	0.8	-0.0	-0.8	-0.5	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.9	0.2	0.2	-1.0	-0.4	-1.4	0.0	0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	2.2	0.5	0.3	-1.5	0.0	1.3	0.3	0.3
Wheeze or whistling in the chest in last year	0.2	0.3	1.4	1.2	0.1	-0.2	-0.5	-0.6	-0.0	0.1
Migraine (self-reported)	0.2	0.2	0.7	-0.0	0.1	-0.8	0.2	-0.7	-0.4	0.1
Medication: Allopurinol	0.2	0.2	0.5	0.2	0.5	-0.1	0.2	0.7	0.7	0.5
Suffer from ‘nerves’	0.2	0.4	0.9	0.7	0.6	-0.7	0.9	-0.4	0.2	0.6
Chest pain or discomfort	0.2	0.3	1.6	0.5	-0.0	-1.3	-0.7	-0.1	-0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	0.3	0.4	-0.9	0.3	-0.3	0.6	0.4
Medication: Aspirin	0.2	0.3	0.6	0.3	0.5	-0.7	-0.2	0.5	0.8	0.6
Whole body fat-free mass	0.2	0.9	3.4	-0.9	-0.9	1.9	-0.5	-0.2	-0.5	-0.9
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	0.5	0.6	-0.2	-0.5	0.4	0.5
Diabetes diagnosed by doctor	0.2	0.2	0.9	-0.9	-0.6	0.3	0.1	0.1	-0.3	-0.6
Medication: Aspirin	0.2	0.3	0.7	0.4	0.7	-0.4	-0.0	0.4	0.9	0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.3	0.6	0.5	-0.3	0.4	0.4	0.5	0.5
Smoking status: Current	0.2	0.3	0.5	0.7	0.7	0.2	0.5	-0.3	0.7	0.7
Whole body water mass	0.2	1.1	3.1	-1.1	-1.0	1.8	-0.6	-0.2	-0.7	-1.0
Basal metabolic rate	0.2	0.9	4.1	-0.8	-0.8	2.0	-0.4	-0.4	-0.4	-0.8
Ever depressed for a whole week	0.2	0.3	0.7	-0.2	-0.3	-0.7	-0.9	-0.8	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.7	-0.3	0.6	-0.6	0.0	0.1	-0.3
Worry (Nagel 2018)	0.1	0.2	0.7	0.3	-0.1	-0.9	-0.2	-0.3	-0.5	-0.1
Crohns Disease (2017)	0.1	0.2	0.4	-0.2	0.2	0.5	-0.7	0.3	0.4	0.2
Major Depression (MDD)	0.1	0.2	0.5	0.7	0.3	-0.4	-0.1	0.4	-0.0	0.3
Breast Cancer	0.1	0.3	1.1	-0.2	0.0	-0.4	-1.0	-0.9	-0.0	0.0
Fasting Glucose	0.1	0.2	0.5	-0.2	-0.0	-0.6	-0.3	-0.7	0.3	-0.0
Lupus	0.1	0.2	0.3	0.4	0.5	0.1	0.4	0.5	0.6	0.5
Ulcerative Colitis	0.1	0.2	0.6	-0.4	-0.1	-0.7	-0.1	0.5	-0.3	-0.1
Blood Platelet Count	0.1	1.2	3.7	1.9	1.0	0.4	1.6	0.4	0.3	1.0
Blood White Count	0.1	1.0	1.9	1.4	1.0	0.7	0.8	0.2	1.2	1.0
Height	0.1	2.1	3.9	-1.6	-1.4	-2.0	-1.4	-0.3	-1.5	-1.4
Lung FVC	0.1	0.5	1.9	0.3	0.0	-1.4	-0.2	1.0	-0.4	0.0
Average weekly spirits intake	0.1	0.2	0.3	0.6	0.5	-0.4	0.2	0.3	0.5	0.5
Relative age of first facial hair	0.1	0.1	0.6	-0.2	-0.3	-0.8	0.2	-0.2	-0.3	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.5	0.4	-0.4	-0.3	0.4	0.2	0.4
Medication: Co-codamol	0.1	0.1	0.6	0.1	0.2	0.2	0.8	-0.4	-0.1	0.2
Medication: Metformin	0.1	0.1	0.5	-0.7	-0.1	-0.1	0.2	0.5	0.3	-0.1
Leg fat-free mass (left)	0.1	0.6	2.3	-0.5	-0.7	1.5	-0.2	-0.2	-0.5	-0.7
Current tobacco smoking	0.1	0.2	0.3	0.6	0.6	-0.3	0.2	-0.1	0.6	0.6
Maternal smoking around birth	0.1	0.2	0.6	0.7	0.2	-0.4	0.8	0.2	0.2	0.2
Sitting height	0.1	0.4	1.8	-0.5	-0.1	-0.6	0.2	1.4	-0.2	-0.2
Leg predicted mass (left)	0.1	0.5	2.2	-0.5	-0.6	1.5	-0.1	-0.1	-0.4	-0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.6	0.4	0.2	0.1	0.4	-0.8	-0.1	0.2
Forced vital capacity (FVC)	0.1	0.5	2.5	0.6	0.4	-0.3	0.0	1.6	0.4	0.4
Allergy	0.1	0.3	0.9	-0.4	-0.0	0.9	0.6	-1.0	-0.1	-0.0
Diabetes (self-reported)	0.1	0.2	0.7	-0.5	-0.3	0.8	0.6	0.2	-0.0	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	-0.4	-0.3	-0.7	0.0	0.3	-0.3	-0.3
Medication: Ramipril	0.1	0.1	0.3	-0.5	-0.1	-0.4	-0.6	-0.5	-0.4	-0.1
Medication: Simvastatin	0.1	0.2	0.5	-0.2	0.6	-0.4	-0.1	-0.2	0.7	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.5	0.1	0.6	0.3	-0.6	0.3	0.1
Standing height	0.1	1.2	2.4	-1.6	-1.2	-0.5	-1.4	0.6	-0.9	-1.2
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.2	-0.1	-0.6	-0.5	-0.0	0.2	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.6	0.1	-0.0	-0.8	-0.3	0.3	-0.1	-0.0
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.1	-0.1	-0.3	-0.4	0.5	-0.6	-0.1
Comparative height size at age 10	0.1	0.4	2.7	0.0	0.0	0.5	0.0	1.6	0.1	0.0
Overall health rating	0.1	0.2	0.6	0.7	0.3	0.4	-0.1	-0.8	0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.7	0.0	0.2	0.1	0.0	0.9	0.4	0.2
Leg fat-free mass (right)	0.1	0.4	1.3	-0.4	-0.7	1.1	0.0	-0.1	-0.5	-0.6
Breast cancer (self-reported)	0.1	0.2	0.3	0.4	0.4	-0.5	0.5	0.5	0.0	0.4
Medication: Gliclazide	0.1	0.2	0.5	-0.4	-0.2	-0.7	0.4	0.5	-0.1	-0.2
Leg predicted mass (right)	0.1	0.4	1.5	-0.4	-0.6	1.2	-0.0	-0.1	-0.5	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.9	0.1	-0.1	0.9	-0.1	-0.3	0.1	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.4	0.2	0.6	-0.1	-0.5	0.7	0.2
Alcohol drinker status: Never	0.1	0.2	0.7	0.4	0.2	-0.8	0.5	0.1	0.1	0.2
Hair Pigment	0.0	0.2	0.6	0.3	0.4	0.2	-0.7	-0.6	0.4	0.4
Tanning	0.0	0.3	1.3	-0.6	-0.3	-1.1	-0.5	0.0	-0.1	-0.3

Hub : Genes

TTC14

Models

Trait associations