Hub : Genes

TTLL7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.106 0.0410 3.0e-04 0.006 NA 0.014 NA 0.001 9.8e-02 NA 3.1e-02 NA 2.6e-01
2 GTEx Liver 0.282 0.1060 2.3e-03 0.192 NA 0.127 NA 0.188 4.8e-06 NA 2.2e-04 NA 6.0e-06
3 ROSMAP Brain Pre-frontal Cortex 0.102 0.0249 4.3e-11 0.101 0.093 0.093 0.093 0.094 5.7e-13 5.0e-12 5.1e-12 5e-12 4.4e-12
4 TCGA Head and Neck Squamous Cell Carcinoma 0.029 0.0168 2.1e-03 0.022 0.014 0.013 NA 0.012 1.6e-03 9.5e-03 1.2e-02 NA 1.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.4 2.3 3.5 -1.1 1.9 1.4 -1.6
Bipolar Disorder or Schizophrenia 0.3 0.8 1.8 0.4 1.4 0.4 -1.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.1 1.0 0.1 -0.5 -0.3
Depression (Nagel 2018) 0.0 0.1 0.3 0.5 -0.1 -0.0 -0.1
Intelligence (Savage-Jansen 2018) 4.1 12.5 16.9 2.6 -4.1 -3.2 4.0
Neuroticism (Nagel 2018) 0.7 1.6 3.8 2.0 -0.5 -1.5 0.2
Schizophrenia (2018) 0.3 0.7 2.2 1.5 0.2 -0.6 0.0
Schizophrenia vs Biploar Disorder 1.2 1.5 3.2 1.8 -0.3 -0.9 1.4
Worry (Nagel 2018) 1.9 4.0 8.1 2.9 -1.1 -2.4 0.9
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 0.7 -0.3 -0.3 0.2
Alzheimer’s Disease (in father) 0.3 0.3 0.7 0.8 0.3 -0.6 -0.2
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.4 0.3 -0.2 -0.5
Crohns Disease (2017) 0.1 0.1 0.2 -0.2 -0.4 -0.2 -0.5
Irritable Bowel Disease (IBD) 0.1 0.1 0.4 -0.3 -0.2 0.1 -0.6
Ulcerative Colitis (UC) 0.1 0.2 0.3 -0.5 -0.2 0.3 -0.5
Major Depression (MDD) 1.2 1.4 1.9 1.3 -1.4 -0.6 1.3
Reaction Time 1.3 2.4 4.3 2.1 -0.5 -1.9 1.2
Verbal and Numeric Reasoning (VNR) 4.3 10.2 14.0 2.6 -3.7 -3.2 3.2
Breast Cancer 0.1 0.2 0.4 0.0 -0.7 -0.1 0.6
Ovarian Cancer 0.6 0.8 2.2 -1.5 -0.3 1.0 -0.3
Prostate Cancer 0.6 0.9 1.6 0.7 -1.1 -0.5 1.3
Age at First Birth 1.0 1.5 2.0 1.0 -1.2 -1.4 1.2
Bipolar Disorder (2011) 2.3 2.2 3.6 -1.1 1.9 0.8 -1.8
Body Mass Index (BMI) (2010) 0.5 0.7 1.3 -1.1 0.6 1.0 -0.2
Coronary Artery Disease (CAD) 0.8 0.9 2.0 -1.4 0.5 1.1 -0.4
Crohns Disease (2012) 0.6 1.0 1.3 -0.8 1.0 1.1 -1.2
Mean Putamen Volume 0.2 0.3 0.5 0.0 -0.7 -0.7 -0.3
Fasting Glucose 0.4 0.5 1.0 -1.0 -0.4 0.8 0.2
HbA1C 3.3 3.7 5.4 -2.0 1.1 2.3 -2.0
HDL Cholesterol 0.8 1.3 1.7 1.3 -1.1 -1.3 1.0
LDL Cholesterol 0.3 0.5 1.1 0.6 -0.6 -0.5 1.0
Lupus 1.4 2.1 2.6 1.5 -1.3 -1.4 1.6
Neuroticism (2016) 0.1 0.1 0.1 -0.3 0.1 0.4 -0.4
Primary Biliary Cirrhosis 1.3 1.8 3.6 1.2 -0.9 -1.9 1.2
Rheumatoid Arthritis 0.3 0.4 1.2 -0.6 1.1 0.3 -0.2
Schizophrenia (2014) 0.4 0.9 2.4 1.6 0.9 -0.5 -0.0
Triglycerides 0.2 0.4 1.1 0.4 -0.3 -0.3 1.1
Type 2 Diabetes (T2D) (2012) 1.1 1.3 1.6 -1.0 1.3 1.1 -1.1
Ulcerative Colitis 0.0 0.1 0.2 0.1 -0.1 0.0 -0.5
Blood Eosinophil Count 0.0 0.3 0.5 -0.5 0.6 0.7 -0.5
Blood Platelet Count 0.1 0.9 1.9 -0.1 1.2 0.4 -1.4
Blood Red Count 0.1 0.6 0.9 0.7 -0.5 -0.9 0.8
Blood White Count 0.4 3.0 4.2 -1.4 1.9 1.5 -2.0
Heel T-Score 0.1 1.0 1.9 -1.0 1.4 0.9 -0.6
BMI 3.8 21.9 29.4 -5.4 4.0 5.0 -4.1
Height 0.0 0.9 2.2 0.6 -1.0 -0.1 1.5
Waist Hip Ratio (WHR) 0.1 0.2 0.8 0.0 0.1 0.3 -0.9
Systolic Blood Pressure 0.2 1.1 1.7 1.3 -0.4 -0.9 1.3
Smoking Status 0.7 1.7 2.8 -1.6 0.5 1.1 -1.7
Allergy or Eczema 1.6 4.1 5.3 1.7 -2.1 -2.0 2.3
Cardiovascular Disease 0.7 2.2 4.5 -2.1 0.9 1.7 -0.9
Hypothyroidism (self reported) 0.7 1.6 2.8 0.8 -1.7 -1.1 1.3
Respiratory disease 0.3 0.8 2.1 -0.1 1.5 -0.5 -0.8
Type 2 Diabetes (T2D) (2018) 5.3 9.9 13.9 -2.8 3.2 3.7 -2.7
Lung FEV1/FVC ratio 0.5 2.3 4.4 1.0 -2.1 -1.6 1.1
Lung FVC 0.6 2.8 6.9 2.6 -0.6 -1.8 0.9
Neuroticism 1.8 4.4 8.8 3.0 -1.0 -2.5 1.2
Chronotype (morning person) 1.8 4.1 7.3 -2.7 0.8 2.6 -1.3
Hair Pigment 0.1 4.1 5.8 1.9 -2.1 -2.4 1.5
Tanning 0.0 0.4 0.7 -0.7 0.8 0.4 -0.5
Hand grip strength (left) 0.1 0.4 0.9 0.4 0.5 -0.5 -0.9
Number of treatments/medications taken 3.8 6.8 9.1 -3.0 2.2 2.8 -2.3
Average weekly spirits intake 1.2 1.5 2.6 -1.5 1.0 0.6 -1.6
Sensitivity / hurt feelings 0.8 1.4 2.6 0.9 -1.6 -0.8 1.2
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 0.4 0.5 0.1 -0.2
Hearing difficulty/problems: Yes 0.6 0.9 2.0 -0.8 -1.4 -0.2 1.0
Relative age of first facial hair 1.0 2.0 5.6 -0.3 -2.4 -0.8 1.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.0 -0.8 0.8 1.0 -0.7
Ever used hormone-replacement therapy (HRT) 2.1 2.7 5.8 -2.4 0.3 2.0 -0.9
Ever had hysterectomy (womb removed) 2.6 2.9 4.9 -1.1 1.6 1.7 -2.2
Systolic blood pressure, automated reading 0.2 0.6 0.9 1.0 0.0 -0.9 0.9
Eye problems/disorders: Diabetes related eye disease 4.8 5.2 8.4 -2.9 1.3 2.7 -1.9
Angina 0.3 0.4 0.9 -0.6 0.2 0.5 -0.9
Medication for hormone replacement therapy 1.8 2.0 3.9 -2.0 1.0 1.7 -0.6
Vitamin and mineral supplements 1.6 2.2 3.6 0.8 -1.6 -1.9 1.4
Supplements: Zinc 1.7 1.8 4.3 2.1 -0.4 -1.5 0.7
Medication: Co-codamol 1.1 1.3 3.0 -0.5 1.7 0.8 -1.2
Medication: Metformin 5.9 8.4 13.5 -3.1 2.6 3.7 -2.0
Diabetes (father) 1.9 2.3 3.0 -0.8 1.7 1.7 -1.6
Diabetes (mother) 2.6 3.4 4.1 -1.5 1.9 2.0 -1.8
Severe depression (siblings) 0.9 1.0 1.7 1.3 -0.4 -1.1 1.0
Pack years adult smoking proportion 1.1 1.6 3.1 -1.0 1.1 1.0 -1.8
Impedance of leg (right) 0.0 0.1 0.3 0.2 0.3 -0.6 -0.1
Leg fat-free mass (left) 0.8 4.4 8.0 -2.7 1.0 2.8 -1.1
Trunk fat percentage 6.4 25.6 31.1 -5.6 4.7 5.4 -4.5
Hand grip strength (right) 0.2 0.4 1.0 -0.1 1.0 0.2 -0.8
Townsend deprivation index at recruitment 0.2 0.3 0.6 0.1 0.8 0.3 -0.6
Current tobacco smoking 0.5 0.8 1.4 -1.0 0.8 0.5 -1.2
Average weekly fortified wine intake 1.0 1.2 2.6 1.6 -0.3 -1.3 0.7
Maternal smoking around birth 0.9 1.3 2.8 -1.7 -0.5 1.5 0.2
Fed-up feelings 0.1 0.1 0.2 -0.4 0.4 0.4 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 0.5 0.1 0.3 0.3
Relative age voice broke 1.5 2.3 4.4 0.5 -2.1 -1.4 1.6
Taking other prescription medications 2.7 4.2 5.4 -2.3 1.6 2.0 -2.2
Age when periods started (menarche) 0.5 1.2 2.4 -1.3 0.7 1.5 -0.5
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 3.7 -1.8 0.7 1.9 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 0.7 -0.2 -0.6 0.5
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.1 0.5 -0.4 -1.1 1.0
Qualifications: CSEs or equivalent 2.0 2.6 4.6 -0.9 2.1 1.6 -1.7
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.1 -0.4 -0.4 -0.1
High blood pressure 2.2 6.2 8.2 -2.9 2.1 2.6 -2.3
Hayfever, allergic rhinitis or eczema 1.2 2.6 3.1 1.3 -1.7 -1.7 1.8
Multivitamins +/- minerals 0.9 1.1 2.2 -0.9 1.0 1.5 -0.7
Stomach or abdominal pain in last month 3.2 4.0 6.7 -1.4 2.6 1.5 -2.3
Supplements: Glucosamine 2.4 3.2 4.4 -2.1 1.3 1.8 -1.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 0.2 0.7 0.3 -0.4
Medication: Atenolol 1.4 1.7 4.1 -2.0 -0.2 1.4 -0.8
Medication: Levothyroxine sodium 0.1 0.1 0.3 -0.4 -0.6 0.2 -0.2
Sitting height 0.1 0.5 1.3 0.5 -0.5 0.2 1.1
Chronic bronchitis/emphysema (father) 1.7 2.0 3.8 -1.5 1.3 1.9 -0.6
High blood pressure (mother) 0.6 0.8 1.3 -1.1 0.5 1.1 -0.6
Body mass index (BMI) 4.5 19.1 25.6 -5.1 3.8 4.8 -3.7
Impedance of leg (left) 0.1 0.6 1.3 0.9 0.4 -1.1 -0.2
Leg predicted mass (left) 0.8 4.3 7.7 -2.7 1.0 2.8 -1.1
Trunk fat mass 5.9 25.2 31.4 -5.6 4.5 5.4 -4.4
Waist circumference 5.2 19.2 25.2 -5.0 3.6 4.9 -3.9
Number of incorrect matches in round 1.2 2.1 3.1 -1.6 0.9 1.3 -1.8
Past tobacco smoking 2.2 4.1 6.2 2.5 -0.9 -2.1 2.2
Alcohol usually taken with meals 0.7 1.1 1.8 1.3 -0.8 -1.4 0.7
Nervous feelings 2.3 4.3 6.7 2.6 -1.8 -2.3 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.2 0.1 0.4 -0.1 -0.2
Hearing difficulty/problems with background noise 3.5 5.6 8.5 1.5 -2.9 -2.3 2.5
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 0.5 -0.6 -0.1 0.4
Had menopause 1.9 2.4 3.3 -1.3 1.4 1.8 -1.6
Had other major operations 0.2 0.3 0.6 -0.7 -0.3 0.6 -0.2
Forced vital capacity (FVC) 0.3 1.2 1.9 1.4 -0.8 -1.1 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.3 0.6 -0.2 0.8 0.6 -0.5
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 0.4 0.6 0.4 0.1
Qualifications: None of the above 2.6 5.5 8.4 -1.6 2.9 2.0 -2.6
Financial difficulties in last 2 years 0.5 0.6 1.3 -1.1 0.3 1.0 -0.3
Mouth/teeth dental problems 0.4 0.6 1.5 0.1 -1.2 -0.4 0.8
Heart attack 1.0 1.2 1.6 -1.2 1.0 1.2 -1.0
Allergy 0.1 0.3 0.7 -0.4 0.2 0.8 -0.6
Pain all over the body in last month 0.5 0.5 1.4 0.4 -1.2 -0.6 0.4
Diabetes (self-reported) 6.6 10.3 14.4 -3.4 2.8 3.8 -2.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.8 0.3 -1.4 -0.8 1.7
Medication: Ramipril 0.4 0.5 1.2 -0.2 1.1 0.7 -0.6
Medication: Simvastatin 5.5 8.1 10.9 -3.3 2.5 3.2 -2.3
Fluid intelligence score 4.4 9.2 12.2 3.1 -2.6 -3.5 2.8
Illnesses of siblings 1.1 1.5 2.3 1.2 -1.1 -1.5 1.1
Neuroticism score 0.6 1.3 2.1 1.4 -1.0 -1.4 0.6
Weight 3.1 15.0 20.8 -4.6 3.2 4.4 -3.1
Impedance of arm (right) 0.2 1.2 2.2 1.3 -0.6 -1.5 0.7
Arm fat percentage (right) 6.2 24.6 28.4 -5.3 4.8 5.2 -4.5
Trunk fat-free mass 0.2 1.2 2.2 -1.4 0.5 1.5 -0.6
Hip circumference 2.5 10.7 15.4 -3.9 2.8 3.6 -2.6
Time employed in main current job 0.6 0.7 1.6 -1.3 -0.9 0.8 -0.1
Alcohol intake versus 10 years previously 0.1 0.2 0.6 -0.5 -0.1 0.1 -0.7
Father’s age at death 0.2 0.2 0.9 0.9 0.3 -0.2 -0.0
Worrier / anxious feelings 0.2 0.3 0.8 0.9 -0.1 -0.5 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 -0.3 0.4 0.2 -0.8
Falls in the last year 2.1 2.8 4.5 -2.1 1.1 1.9 -1.4
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.6 -0.4 -0.8 0.1
Number of live births 0.1 0.2 0.4 -0.6 -0.2 0.6 -0.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 2.8 1.5 -1.3 -1.1 1.7
Pulse rate 0.2 0.4 0.8 -0.9 0.6 0.3 -0.6
Happiness 0.3 0.3 0.7 0.6 -0.4 -0.4 0.8
Noisy workplace 1.5 1.9 2.0 -1.4 1.4 1.3 -1.3
Qualifications: A levels/AS levels or equivalent 3.1 6.9 11.8 3.4 -1.9 -2.9 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.1 -0.1 1.5 0.2 -0.8
Mouth/teeth dental problems: Dentures 0.9 1.6 3.4 -0.6 1.5 0.5 -1.9
Asthma 0.4 0.9 2.6 -0.2 1.6 -0.2 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.1 -1.4 0.0 1.4 -0.5
Medication: Cholesterol lowering 5.8 9.1 11.9 -3.5 2.5 2.8 -3.2
Depression (self-reported) 0.3 0.4 0.9 0.1 1.0 0.4 -0.5
Medication: Lansoprazole 1.4 1.6 2.7 -1.6 0.9 1.5 -0.8
Prospective memory result 0.1 0.1 0.2 0.5 0.2 -0.1 -0.2
Lung cancer (father) 0.7 0.9 1.4 -1.2 0.4 1.2 -0.6
Illnesses of mother 1.0 1.2 2.3 1.5 -0.3 -1.4 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 4.5 2.1 -1.9 -1.8 2.0
Pulse wave Arterial Stiffness index 1.1 1.2 2.6 -1.3 0.5 1.6 -0.6
Impedance of arm (left) 0.1 0.6 1.1 0.9 -0.2 -1.1 0.5
Arm fat mass (right) 5.5 22.6 29.2 -5.4 4.2 5.2 -4.1
Trunk predicted mass 0.2 1.2 2.2 -1.4 0.6 1.5 -0.7
Standing height 0.1 0.6 1.2 0.5 -0.9 -0.2 1.1
Length of working week for main job 7.5 8.3 13.4 -3.7 1.9 3.3 -2.3
Exposure to tobacco smoke at home 0.6 0.7 1.9 0.7 -0.4 -0.4 1.4
Breastfed as a baby 1.9 2.4 3.9 2.0 -0.8 -1.8 1.3
Tense / ‘highly strung’ 1.2 2.0 3.1 1.4 -1.4 -1.8 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.8 1.4 -0.6 -1.2 0.7
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.0 0.3 -0.1 -0.3
Birth weight of first child 0.3 0.6 1.0 -0.9 0.6 0.6 -1.0
Peak expiratory flow (PEF) 0.4 0.9 1.4 1.0 -0.9 -0.7 1.2
Pulse wave reflection index 0.2 0.3 0.7 0.2 -0.8 0.2 0.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 1.4 0.8 -1.2 -1.2 1.1
Loud music exposure frequency 1.2 1.3 3.1 -1.8 -0.4 1.1 -0.9
Qualifications: O levels/GCSEs or equivalent 2.5 4.0 4.9 1.6 -2.2 -1.9 2.2
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.3 -1.5 0.8 1.3 -0.1
Blood clot in the leg (DVT) 1.0 1.4 2.1 1.4 -0.8 -1.0 1.3
Medication: Paracetamol 3.6 6.0 9.2 -3.0 1.2 2.8 -2.3
Headache pain in last month 0.4 0.7 1.4 0.7 -0.6 -1.2 0.7
Medication for cholesterol, blood pressure or diabetes 2.5 4.2 5.9 2.4 -1.9 -1.9 1.9
Glaucoma (self-reported) 0.8 1.0 1.8 -1.4 -1.4 0.2 0.5
Gout (self-reported) 0.7 1.0 2.0 -1.4 -0.2 1.4 -0.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.6 -0.4 -0.8 0.1 -0.2
Medication: Amlodipine 0.3 0.4 0.8 0.9 -0.6 -0.6 0.2
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.5 1.2 0.6 -0.8 0.4
Birth weight 0.1 0.1 0.2 -0.5 0.4 0.1 -0.2
Chronic bronchitis/emphysema (mother) 3.2 3.8 5.1 -2.3 1.6 2.2 -1.6
High blood pressure (siblings) 1.2 1.8 2.6 -1.2 0.9 1.6 -1.5
Forced vital capacity (FVC), Best measure 1.2 4.3 6.4 2.5 -1.7 -2.0 2.0
Body fat percentage 7.1 28.2 32.9 -5.7 5.1 5.5 -4.8
Leg fat percentage (right) 7.6 27.6 34.3 -5.9 4.8 5.5 -4.8
Arm fat-free mass (right) 0.7 3.8 6.8 -2.4 1.1 2.6 -1.1
Exposure to tobacco smoke outside home 1.3 1.7 2.6 -0.9 1.4 1.2 -1.6
Comparative body size at age 10 0.1 0.4 0.6 0.1 -0.8 -0.6 0.7
Number of full brothers 0.1 0.1 0.3 0.4 0.2 -0.5 0.2
Worry too long after embarrassment 1.2 2.1 2.8 1.5 -1.7 -1.4 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 3.2 4.2 6.2 -1.4 2.3 1.8 -2.5
Wheeze or whistling in the chest in last year 1.8 3.1 5.1 -2.2 1.7 1.6 -1.4
Number of children fathered 0.8 0.9 1.3 1.1 -0.4 -1.0 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.5 0.8 -0.9 -1.0 1.2
Age at first live birth 3.2 5.6 7.9 2.8 -1.9 -2.7 1.9
Pulse wave peak to peak time 1.2 1.4 2.9 1.3 -0.7 -1.7 0.8
Health satisfaction 0.3 0.4 1.3 -1.1 -0.3 0.6 0.0
Shortness of breath walking on level ground 1.7 2.0 3.8 -1.0 2.0 1.1 -1.4
Qualifications: College or University degree 3.6 11.2 12.0 3.4 -3.1 -3.4 3.5
Eye problems/disorders: None of the above 1.5 1.7 3.1 1.8 -0.8 -1.3 1.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.9 -1.0 0.9 0.5 -0.7
Emphysema/chronic bronchitis 3.1 3.5 4.3 -1.9 2.1 1.9 -1.6
Medication for pain relief, constipation, heartburn 7.2 12.3 15.8 3.9 -2.4 -4.0 3.5
Neck or shoulder pain in last month 3.9 5.5 6.8 -2.6 2.1 2.3 -2.3
Medication: Blood pressure 1.4 2.5 3.5 -1.5 1.9 1.5 -1.5
Angina (self-reported) 0.2 0.3 0.8 -0.2 0.2 0.3 -0.9
Migraine (self-reported) 0.4 0.5 0.7 -0.1 0.8 0.8 -0.8
Medication: Ibuprofen 0.3 0.4 0.6 -0.8 -0.7 0.8 0.1
Medication: Allopurinol 0.6 0.8 1.8 -1.1 0.3 1.3 -0.4
Medication: Omeprazole 1.4 1.6 2.0 -1.0 1.4 1.3 -1.4
Medication: Seretide 50 evohaler 0.5 0.6 0.7 0.6 0.7 -0.8 -0.9
Mean time to correctly identify matches 1.1 2.1 4.1 2.0 -0.4 -2.0 0.6
Heart disease (mother) 0.7 0.9 1.7 1.0 -0.7 -0.6 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.8 4.8 -1.9 1.3 2.2 -1.0
Whole body fat mass 6.8 28.4 34.0 -5.8 4.9 5.7 -4.8
Leg fat mass (right) 7.2 27.9 37.1 -6.1 4.6 5.8 -4.5
Arm predicted mass (right) 1.1 5.8 9.8 -2.8 1.7 3.1 -1.6
Pulse rate, automated reading 0.2 0.6 1.3 -0.5 0.9 -0.0 -1.1
Alcohol intake frequency. 0.1 0.1 0.3 0.4 -0.5 0.0 0.3
Comparative height size at age 10 0.1 0.4 1.3 1.1 0.2 -0.6 0.1
Number of full sisters 0.9 1.1 1.5 -0.8 1.0 1.2 -1.2
Suffer from ‘nerves’ 2.9 4.6 5.6 2.4 -2.1 -2.3 1.7
Overall health rating 4.9 10.4 11.9 -3.2 3.0 3.5 -3.2
Chest pain or discomfort 1.5 2.2 3.2 -1.2 1.8 1.5 -1.4
Had major operations 0.9 1.1 1.7 -1.3 1.0 1.2 -0.2
Age at last live birth 4.6 6.7 9.1 3.0 -2.4 -2.7 2.2
Family relationship satisfaction 2.5 3.0 4.1 1.9 -1.5 -1.4 2.0
Leg pain on walking 6.8 8.6 9.9 -3.1 2.7 3.0 -2.9
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 2.3 -1.5 1.5 1.4 -1.3
Commuting to job workplace: Car/motor vehicle 0.6 0.6 1.3 -1.1 0.1 1.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.7 0.5 -0.9 -0.8 0.8
Medication: Aspirin 1.6 2.1 2.4 -1.6 1.3 1.5 -1.5
Supplements: Vitamin C 0.0 0.0 0.0 -0.0 -0.1 0.1 -0.2
Knee pain experienced in last month 5.8 9.0 13.8 -3.7 2.2 3.2 -2.7
Hypertension (Self-reported) 2.2 6.1 8.8 -3.0 1.9 2.6 -2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.2 0.1 1.5 0.4 -0.5
Illnesses of father: Heart disease 2.3 3.2 5.0 1.5 -2.0 -1.2 2.2
Illnesses of siblings: Diabetes 4.4 5.4 8.0 -2.0 2.8 2.4 -2.0
Smoking status: Previous 2.3 3.5 5.2 -2.3 0.8 2.1 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.0 0.1 -2.0 -0.2 1.4
Whole body fat-free mass 0.4 2.4 4.5 -1.9 0.9 2.1 -0.9
Leg fat-free mass (right) 0.5 2.6 5.0 -2.0 0.7 2.2 -0.8
Arm fat percentage (left) 5.9 23.4 27.7 -5.3 4.7 5.1 -4.3
Average weekly red wine intake 0.1 0.2 0.5 -0.2 0.7 0.3 -0.5
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.6 2.1 -0.4 -1.5 0.5
Mood swings 0.9 1.6 1.7 -1.2 1.2 1.3 -1.3
Loneliness, isolation 1.5 2.0 3.0 1.7 -1.2 -1.2 1.4
Long-standing illness, disability or infirmity 4.5 6.9 8.1 -2.4 2.8 2.8 -2.5
Ever had bowel cancer screening 1.0 1.1 1.3 -1.1 1.1 1.0 -1.0
Diabetes diagnosed by doctor 8.8 14.5 18.7 -3.7 3.6 4.3 -3.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.2 0.7 -0.2 -0.5 1.1
Friendships satisfaction 0.2 0.2 0.6 -0.1 0.5 0.0 0.8
Qualifications: nursing, teaching 0.9 1.4 1.8 1.2 -1.0 -1.4 1.2
Commuting to job workplace: Walk 2.1 2.3 2.9 0.9 -1.7 -1.7 1.7
Eye problems/disorders: Cataract 0.4 0.5 0.7 -0.5 0.9 0.6 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 -0.0 0.4 0.5 0.1
Medication for cholesterol 3.7 5.6 8.6 2.8 -1.9 -2.9 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.7 -0.8 0.7 1.3 -0.7
Back pain experienced in last month 4.7 6.8 10.3 -3.2 2.1 2.6 -2.4
Mineral and other dietary supplements 4.5 6.1 9.4 2.6 -1.8 -3.1 2.3
Breast cancer (self-reported) 0.6 0.7 2.2 -0.5 0.3 0.5 -1.5
Asthma (self-reported) 0.4 0.7 1.9 0.2 1.4 -0.7 -0.6
Osteoporosis (self-reported) 1.0 1.3 2.1 -0.5 1.2 1.1 -1.4
Osteoarthritis (self-reported) 1.7 2.2 4.2 -2.1 0.8 1.6 -1.1
Medication: Aspirin 2.7 3.5 4.6 -2.1 1.4 1.9 -2.0
Medication: Gliclazide 0.2 0.2 0.5 0.2 0.7 0.4 -0.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.6 0.4 0.4 -0.2
Smoking status: Current 0.4 0.6 1.4 -0.8 0.6 0.3 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 3.8 1.9 -0.8 -1.6 1.2
Whole body water mass 0.4 2.4 4.4 -1.9 0.8 2.1 -0.9
Leg predicted mass (right) 0.5 2.5 4.9 -1.9 0.8 2.2 -0.9
Arm fat mass (left) 5.6 22.9 29.3 -5.4 4.3 5.2 -4.1
Number of self-reported non-cancer illnesses 4.7 8.2 11.4 -3.4 2.4 3.2 -2.4
Average weekly champagne plus white wine intake 0.1 0.1 0.3 -0.2 -0.2 -0.6 0.0
Miserableness 0.2 0.4 1.2 1.1 0.4 -0.2 -0.2
Guilty feelings 0.1 0.2 0.6 0.2 -0.5 -0.2 0.8
Wears glasses or contact lenses 0.3 0.3 0.8 0.0 0.9 -0.4 -0.5
Ever taken oral contraceptive pill 0.1 0.1 0.3 -0.6 -0.3 0.1 0.1
Hearing aid user 3.2 3.6 6.4 -2.5 1.2 1.9 -1.6
Mother’s age at death 2.1 2.7 5.8 1.8 -1.2 -2.4 0.1
Financial situation satisfaction 2.4 2.9 5.9 -0.9 2.4 1.6 -1.5
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.0 -0.1 -1.0 0.0 0.3
Commuting to job workplace: Public transport 1.5 1.8 3.2 1.6 -0.9 -1.8 0.6
Eye problems/disorders: Glaucoma 0.7 0.8 1.8 -1.0 -1.4 0.2 0.6
Medication: Blood pressure 0.7 1.3 1.8 -1.1 1.3 1.3 -0.9
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.8 0.2 -1.4 -0.5 1.3
Supplements: Fish oil (including cod liver oil) 1.7 2.3 3.9 -1.6 0.8 2.0 -1.4
High cholesterol (Self-reported) 1.7 3.1 4.9 -2.2 1.4 2.1 -1.1
Medication: Bendroflumethiazide 1.5 2.2 3.8 -2.0 1.1 1.6 -1.2
Medication: Paracetamol 1.8 2.7 5.2 -2.3 0.3 1.9 -1.4
Medication: Lisinopril 0.9 1.2 3.5 -1.9 0.5 0.9 -0.7
Medication: Atorvastatin 0.3 0.4 0.6 -0.5 0.7 0.5 -0.7
Illnesses of father: High blood pressure 0.1 0.1 0.4 -0.1 -0.6 0.2 0.2
Alcohol drinker status: Never 1.1 1.4 3.0 -1.4 0.1 1.7 -0.7
Ever smoked 0.1 0.1 0.4 -0.2 -0.6 -0.3 -0.1
Basal metabolic rate 0.9 4.9 7.7 -2.7 1.5 2.8 -1.5
Leg fat percentage (left) 6.5 23.5 26.9 -5.2 4.6 4.9 -4.7
Arm fat-free mass (left) 1.0 4.9 7.6 -2.6 1.6 2.8 -1.7
Number of operations (self-reported) 0.8 1.2 2.5 -1.6 0.0 1.4 0.5
Average weekly beer plus cider intake 0.3 0.5 0.9 -0.9 -0.4 0.8 0.4
Irritability 0.0 0.1 0.1 -0.4 -0.3 -0.1 -0.1
Risk taking 0.5 0.8 1.6 0.2 -1.0 -0.7 1.3
Ever had prostate specific antigen (PSA) test 1.7 2.0 2.4 -1.5 1.4 1.2 -1.6
Fractured/broken bones in last 5 years 3.2 4.2 7.6 -2.3 1.1 2.8 -1.6
Age started oral contraceptive pill 0.7 0.9 1.7 1.3 -0.8 -0.8 0.8
Diastolic blood pressure, automated reading 0.2 0.8 2.0 0.8 -0.2 -0.7 1.4
Ever depressed for a whole week 0.1 0.1 0.2 -0.1 -0.4 0.3 0.2
Unable to work because of sickness or disability 1.3 1.7 2.7 -0.8 1.6 1.1 -1.5
Commuting to job workplace: Cycle 0.3 0.3 0.7 0.3 -0.7 -0.1 0.8
Myopia 0.3 0.5 1.1 -1.1 0.2 0.6 -0.6
Vascular/heart problems diagnosed by doctor 1.8 5.0 7.2 2.7 -1.8 -2.4 2.0
Cholesterol lowering medication 2.3 3.3 6.0 -1.8 1.7 2.4 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.3 -0.6 0.9 0.9 -1.1
Pain experienced in last month 0.9 1.6 4.2 2.1 -0.1 -1.1 0.9
Supplements: Calcium 1.4 1.6 3.0 -1.5 0.4 1.7 -1.0
Basal cell carcinoma (self-reported) 1.7 2.0 2.6 1.2 -1.5 -1.3 1.6
Heart attack/myocardial infarction (self-reported) 0.8 1.1 1.3 -1.2 0.8 1.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 1.8 1.4 -0.6 -0.9 1.1
Heart disease (siblings) 0.4 0.5 1.0 -0.6 -0.3 0.7 1.0
Alcohol drinker status: Previous 1.4 1.6 2.4 -1.3 0.9 1.6 -1.3
Pack years of smoking 1.5 2.3 4.4 -1.3 1.2 1.2 -2.1
Impedance of whole body 0.1 0.7 1.6 1.1 -0.1 -1.2 0.5
Leg fat mass (left) 6.7 26.0 33.1 -5.8 4.5 5.5 -4.5
Arm predicted mass (left) 0.8 3.9 6.4 -2.2 1.5 2.5 -1.5