Hub : Genes

TTLL7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.106	0.0410	3.0e-04	0.006	NA	0.014	NA	0.001	9.8e-02	NA	3.1e-02	NA	2.6e-01
2	GTEx	Liver	0.282	0.1060	2.3e-03	0.192	NA	0.127	NA	0.188	4.8e-06	NA	2.2e-04	NA	6.0e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.102	0.0249	4.3e-11	0.101	0.093	0.093	0.093	0.094	5.7e-13	5.0e-12	5.1e-12	5e-12	4.4e-12
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.029	0.0168	2.1e-03	0.022	0.014	0.013	NA	0.012	1.6e-03	9.5e-03	1.2e-02	NA	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.3	3.5	-1.1	1.9	1.4	-1.6
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	0.4	1.4	0.4	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	1.0	0.1	-0.5	-0.3
Depression (Nagel 2018)	0.0	0.1	0.3	0.5	-0.1	-0.0	-0.1
Intelligence (Savage-Jansen 2018)	4.1	12.5	16.9	2.6	-4.1	-3.2	4.0
Neuroticism (Nagel 2018)	0.7	1.6	3.8	2.0	-0.5	-1.5	0.2
Schizophrenia (2018)	0.3	0.7	2.2	1.5	0.2	-0.6	0.0
Schizophrenia vs Biploar Disorder	1.2	1.5	3.2	1.8	-0.3	-0.9	1.4
Worry (Nagel 2018)	1.9	4.0	8.1	2.9	-1.1	-2.4	0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.7	-0.3	-0.3	0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.8	0.3	-0.6	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.4	0.3	-0.2	-0.5
Crohns Disease (2017)	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.5
Irritable Bowel Disease (IBD)	0.1	0.1	0.4	-0.3	-0.2	0.1	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.5	-0.2	0.3	-0.5
Major Depression (MDD)	1.2	1.4	1.9	1.3	-1.4	-0.6	1.3
Reaction Time	1.3	2.4	4.3	2.1	-0.5	-1.9	1.2
Verbal and Numeric Reasoning (VNR)	4.3	10.2	14.0	2.6	-3.7	-3.2	3.2
Breast Cancer	0.1	0.2	0.4	0.0	-0.7	-0.1	0.6
Ovarian Cancer	0.6	0.8	2.2	-1.5	-0.3	1.0	-0.3
Prostate Cancer	0.6	0.9	1.6	0.7	-1.1	-0.5	1.3
Age at First Birth	1.0	1.5	2.0	1.0	-1.2	-1.4	1.2
Bipolar Disorder (2011)	2.3	2.2	3.6	-1.1	1.9	0.8	-1.8
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-1.1	0.6	1.0	-0.2
Coronary Artery Disease (CAD)	0.8	0.9	2.0	-1.4	0.5	1.1	-0.4
Crohns Disease (2012)	0.6	1.0	1.3	-0.8	1.0	1.1	-1.2
Mean Putamen Volume	0.2	0.3	0.5	0.0	-0.7	-0.7	-0.3
Fasting Glucose	0.4	0.5	1.0	-1.0	-0.4	0.8	0.2
HbA1C	3.3	3.7	5.4	-2.0	1.1	2.3	-2.0
HDL Cholesterol	0.8	1.3	1.7	1.3	-1.1	-1.3	1.0
LDL Cholesterol	0.3	0.5	1.1	0.6	-0.6	-0.5	1.0
Lupus	1.4	2.1	2.6	1.5	-1.3	-1.4	1.6
Neuroticism (2016)	0.1	0.1	0.1	-0.3	0.1	0.4	-0.4
Primary Biliary Cirrhosis	1.3	1.8	3.6	1.2	-0.9	-1.9	1.2
Rheumatoid Arthritis	0.3	0.4	1.2	-0.6	1.1	0.3	-0.2
Schizophrenia (2014)	0.4	0.9	2.4	1.6	0.9	-0.5	-0.0
Triglycerides	0.2	0.4	1.1	0.4	-0.3	-0.3	1.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.6	-1.0	1.3	1.1	-1.1
Ulcerative Colitis	0.0	0.1	0.2	0.1	-0.1	0.0	-0.5
Blood Eosinophil Count	0.0	0.3	0.5	-0.5	0.6	0.7	-0.5
Blood Platelet Count	0.1	0.9	1.9	-0.1	1.2	0.4	-1.4
Blood Red Count	0.1	0.6	0.9	0.7	-0.5	-0.9	0.8
Blood White Count	0.4	3.0	4.2	-1.4	1.9	1.5	-2.0
Heel T-Score	0.1	1.0	1.9	-1.0	1.4	0.9	-0.6
BMI	3.8	21.9	29.4	-5.4	4.0	5.0	-4.1
Height	0.0	0.9	2.2	0.6	-1.0	-0.1	1.5
Waist Hip Ratio (WHR)	0.1	0.2	0.8	0.0	0.1	0.3	-0.9
Systolic Blood Pressure	0.2	1.1	1.7	1.3	-0.4	-0.9	1.3
Smoking Status	0.7	1.7	2.8	-1.6	0.5	1.1	-1.7
Allergy or Eczema	1.6	4.1	5.3	1.7	-2.1	-2.0	2.3
Cardiovascular Disease	0.7	2.2	4.5	-2.1	0.9	1.7	-0.9
Hypothyroidism (self reported)	0.7	1.6	2.8	0.8	-1.7	-1.1	1.3
Respiratory disease	0.3	0.8	2.1	-0.1	1.5	-0.5	-0.8
Type 2 Diabetes (T2D) (2018)	5.3	9.9	13.9	-2.8	3.2	3.7	-2.7
Lung FEV1/FVC ratio	0.5	2.3	4.4	1.0	-2.1	-1.6	1.1
Lung FVC	0.6	2.8	6.9	2.6	-0.6	-1.8	0.9
Neuroticism	1.8	4.4	8.8	3.0	-1.0	-2.5	1.2
Chronotype (morning person)	1.8	4.1	7.3	-2.7	0.8	2.6	-1.3
Hair Pigment	0.1	4.1	5.8	1.9	-2.1	-2.4	1.5
Tanning	0.0	0.4	0.7	-0.7	0.8	0.4	-0.5
Hand grip strength (left)	0.1	0.4	0.9	0.4	0.5	-0.5	-0.9
Number of treatments/medications taken	3.8	6.8	9.1	-3.0	2.2	2.8	-2.3
Average weekly spirits intake	1.2	1.5	2.6	-1.5	1.0	0.6	-1.6
Sensitivity / hurt feelings	0.8	1.4	2.6	0.9	-1.6	-0.8	1.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.4	0.5	0.1	-0.2
Hearing difficulty/problems: Yes	0.6	0.9	2.0	-0.8	-1.4	-0.2	1.0
Relative age of first facial hair	1.0	2.0	5.6	-0.3	-2.4	-0.8	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	-0.8	0.8	1.0	-0.7
Ever used hormone-replacement therapy (HRT)	2.1	2.7	5.8	-2.4	0.3	2.0	-0.9
Ever had hysterectomy (womb removed)	2.6	2.9	4.9	-1.1	1.6	1.7	-2.2
Systolic blood pressure, automated reading	0.2	0.6	0.9	1.0	0.0	-0.9	0.9
Eye problems/disorders: Diabetes related eye disease	4.8	5.2	8.4	-2.9	1.3	2.7	-1.9
Angina	0.3	0.4	0.9	-0.6	0.2	0.5	-0.9
Medication for hormone replacement therapy	1.8	2.0	3.9	-2.0	1.0	1.7	-0.6
Vitamin and mineral supplements	1.6	2.2	3.6	0.8	-1.6	-1.9	1.4
Supplements: Zinc	1.7	1.8	4.3	2.1	-0.4	-1.5	0.7
Medication: Co-codamol	1.1	1.3	3.0	-0.5	1.7	0.8	-1.2
Medication: Metformin	5.9	8.4	13.5	-3.1	2.6	3.7	-2.0
Diabetes (father)	1.9	2.3	3.0	-0.8	1.7	1.7	-1.6
Diabetes (mother)	2.6	3.4	4.1	-1.5	1.9	2.0	-1.8
Severe depression (siblings)	0.9	1.0	1.7	1.3	-0.4	-1.1	1.0
Pack years adult smoking proportion	1.1	1.6	3.1	-1.0	1.1	1.0	-1.8
Impedance of leg (right)	0.0	0.1	0.3	0.2	0.3	-0.6	-0.1
Leg fat-free mass (left)	0.8	4.4	8.0	-2.7	1.0	2.8	-1.1
Trunk fat percentage	6.4	25.6	31.1	-5.6	4.7	5.4	-4.5
Hand grip strength (right)	0.2	0.4	1.0	-0.1	1.0	0.2	-0.8
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.1	0.8	0.3	-0.6
Current tobacco smoking	0.5	0.8	1.4	-1.0	0.8	0.5	-1.2
Average weekly fortified wine intake	1.0	1.2	2.6	1.6	-0.3	-1.3	0.7
Maternal smoking around birth	0.9	1.3	2.8	-1.7	-0.5	1.5	0.2
Fed-up feelings	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.5	0.1	0.3	0.3
Relative age voice broke	1.5	2.3	4.4	0.5	-2.1	-1.4	1.6
Taking other prescription medications	2.7	4.2	5.4	-2.3	1.6	2.0	-2.2
Age when periods started (menarche)	0.5	1.2	2.4	-1.3	0.7	1.5	-0.5
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	3.7	-1.8	0.7	1.9	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.7	-0.2	-0.6	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	0.5	-0.4	-1.1	1.0
Qualifications: CSEs or equivalent	2.0	2.6	4.6	-0.9	2.1	1.6	-1.7
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.1	-0.4	-0.4	-0.1
High blood pressure	2.2	6.2	8.2	-2.9	2.1	2.6	-2.3
Hayfever, allergic rhinitis or eczema	1.2	2.6	3.1	1.3	-1.7	-1.7	1.8
Multivitamins +/- minerals	0.9	1.1	2.2	-0.9	1.0	1.5	-0.7
Stomach or abdominal pain in last month	3.2	4.0	6.7	-1.4	2.6	1.5	-2.3
Supplements: Glucosamine	2.4	3.2	4.4	-2.1	1.3	1.8	-1.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.2	0.7	0.3	-0.4
Medication: Atenolol	1.4	1.7	4.1	-2.0	-0.2	1.4	-0.8
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.4	-0.6	0.2	-0.2
Sitting height	0.1	0.5	1.3	0.5	-0.5	0.2	1.1
Chronic bronchitis/emphysema (father)	1.7	2.0	3.8	-1.5	1.3	1.9	-0.6
High blood pressure (mother)	0.6	0.8	1.3	-1.1	0.5	1.1	-0.6
Body mass index (BMI)	4.5	19.1	25.6	-5.1	3.8	4.8	-3.7
Impedance of leg (left)	0.1	0.6	1.3	0.9	0.4	-1.1	-0.2
Leg predicted mass (left)	0.8	4.3	7.7	-2.7	1.0	2.8	-1.1
Trunk fat mass	5.9	25.2	31.4	-5.6	4.5	5.4	-4.4
Waist circumference	5.2	19.2	25.2	-5.0	3.6	4.9	-3.9
Number of incorrect matches in round	1.2	2.1	3.1	-1.6	0.9	1.3	-1.8
Past tobacco smoking	2.2	4.1	6.2	2.5	-0.9	-2.1	2.2
Alcohol usually taken with meals	0.7	1.1	1.8	1.3	-0.8	-1.4	0.7
Nervous feelings	2.3	4.3	6.7	2.6	-1.8	-2.3	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	0.1	0.4	-0.1	-0.2
Hearing difficulty/problems with background noise	3.5	5.6	8.5	1.5	-2.9	-2.3	2.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	0.5	-0.6	-0.1	0.4
Had menopause	1.9	2.4	3.3	-1.3	1.4	1.8	-1.6
Had other major operations	0.2	0.3	0.6	-0.7	-0.3	0.6	-0.2
Forced vital capacity (FVC)	0.3	1.2	1.9	1.4	-0.8	-1.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	0.6	-0.2	0.8	0.6	-0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	0.4	0.6	0.4	0.1
Qualifications: None of the above	2.6	5.5	8.4	-1.6	2.9	2.0	-2.6
Financial difficulties in last 2 years	0.5	0.6	1.3	-1.1	0.3	1.0	-0.3
Mouth/teeth dental problems	0.4	0.6	1.5	0.1	-1.2	-0.4	0.8
Heart attack	1.0	1.2	1.6	-1.2	1.0	1.2	-1.0
Allergy	0.1	0.3	0.7	-0.4	0.2	0.8	-0.6
Pain all over the body in last month	0.5	0.5	1.4	0.4	-1.2	-0.6	0.4
Diabetes (self-reported)	6.6	10.3	14.4	-3.4	2.8	3.8	-2.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.8	0.3	-1.4	-0.8	1.7
Medication: Ramipril	0.4	0.5	1.2	-0.2	1.1	0.7	-0.6
Medication: Simvastatin	5.5	8.1	10.9	-3.3	2.5	3.2	-2.3
Fluid intelligence score	4.4	9.2	12.2	3.1	-2.6	-3.5	2.8
Illnesses of siblings	1.1	1.5	2.3	1.2	-1.1	-1.5	1.1
Neuroticism score	0.6	1.3	2.1	1.4	-1.0	-1.4	0.6
Weight	3.1	15.0	20.8	-4.6	3.2	4.4	-3.1
Impedance of arm (right)	0.2	1.2	2.2	1.3	-0.6	-1.5	0.7
Arm fat percentage (right)	6.2	24.6	28.4	-5.3	4.8	5.2	-4.5
Trunk fat-free mass	0.2	1.2	2.2	-1.4	0.5	1.5	-0.6
Hip circumference	2.5	10.7	15.4	-3.9	2.8	3.6	-2.6
Time employed in main current job	0.6	0.7	1.6	-1.3	-0.9	0.8	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.6	-0.5	-0.1	0.1	-0.7
Father’s age at death	0.2	0.2	0.9	0.9	0.3	-0.2	-0.0
Worrier / anxious feelings	0.2	0.3	0.8	0.9	-0.1	-0.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.3	0.4	0.2	-0.8
Falls in the last year	2.1	2.8	4.5	-2.1	1.1	1.9	-1.4
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.6	-0.4	-0.8	0.1
Number of live births	0.1	0.2	0.4	-0.6	-0.2	0.6	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	2.8	1.5	-1.3	-1.1	1.7
Pulse rate	0.2	0.4	0.8	-0.9	0.6	0.3	-0.6
Happiness	0.3	0.3	0.7	0.6	-0.4	-0.4	0.8
Noisy workplace	1.5	1.9	2.0	-1.4	1.4	1.3	-1.3
Qualifications: A levels/AS levels or equivalent	3.1	6.9	11.8	3.4	-1.9	-2.9	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.1	-0.1	1.5	0.2	-0.8
Mouth/teeth dental problems: Dentures	0.9	1.6	3.4	-0.6	1.5	0.5	-1.9
Asthma	0.4	0.9	2.6	-0.2	1.6	-0.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	-1.4	0.0	1.4	-0.5
Medication: Cholesterol lowering	5.8	9.1	11.9	-3.5	2.5	2.8	-3.2
Depression (self-reported)	0.3	0.4	0.9	0.1	1.0	0.4	-0.5
Medication: Lansoprazole	1.4	1.6	2.7	-1.6	0.9	1.5	-0.8
Prospective memory result	0.1	0.1	0.2	0.5	0.2	-0.1	-0.2
Lung cancer (father)	0.7	0.9	1.4	-1.2	0.4	1.2	-0.6
Illnesses of mother	1.0	1.2	2.3	1.5	-0.3	-1.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	4.5	2.1	-1.9	-1.8	2.0
Pulse wave Arterial Stiffness index	1.1	1.2	2.6	-1.3	0.5	1.6	-0.6
Impedance of arm (left)	0.1	0.6	1.1	0.9	-0.2	-1.1	0.5
Arm fat mass (right)	5.5	22.6	29.2	-5.4	4.2	5.2	-4.1
Trunk predicted mass	0.2	1.2	2.2	-1.4	0.6	1.5	-0.7
Standing height	0.1	0.6	1.2	0.5	-0.9	-0.2	1.1
Length of working week for main job	7.5	8.3	13.4	-3.7	1.9	3.3	-2.3
Exposure to tobacco smoke at home	0.6	0.7	1.9	0.7	-0.4	-0.4	1.4
Breastfed as a baby	1.9	2.4	3.9	2.0	-0.8	-1.8	1.3
Tense / ‘highly strung’	1.2	2.0	3.1	1.4	-1.4	-1.8	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.8	1.4	-0.6	-1.2	0.7
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.0	0.3	-0.1	-0.3
Birth weight of first child	0.3	0.6	1.0	-0.9	0.6	0.6	-1.0
Peak expiratory flow (PEF)	0.4	0.9	1.4	1.0	-0.9	-0.7	1.2
Pulse wave reflection index	0.2	0.3	0.7	0.2	-0.8	0.2	0.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.4	0.8	-1.2	-1.2	1.1
Loud music exposure frequency	1.2	1.3	3.1	-1.8	-0.4	1.1	-0.9
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	4.9	1.6	-2.2	-1.9	2.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.3	-1.5	0.8	1.3	-0.1
Blood clot in the leg (DVT)	1.0	1.4	2.1	1.4	-0.8	-1.0	1.3
Medication: Paracetamol	3.6	6.0	9.2	-3.0	1.2	2.8	-2.3
Headache pain in last month	0.4	0.7	1.4	0.7	-0.6	-1.2	0.7
Medication for cholesterol, blood pressure or diabetes	2.5	4.2	5.9	2.4	-1.9	-1.9	1.9
Glaucoma (self-reported)	0.8	1.0	1.8	-1.4	-1.4	0.2	0.5
Gout (self-reported)	0.7	1.0	2.0	-1.4	-0.2	1.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.4	-0.8	0.1	-0.2
Medication: Amlodipine	0.3	0.4	0.8	0.9	-0.6	-0.6	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.5	1.2	0.6	-0.8	0.4
Birth weight	0.1	0.1	0.2	-0.5	0.4	0.1	-0.2
Chronic bronchitis/emphysema (mother)	3.2	3.8	5.1	-2.3	1.6	2.2	-1.6
High blood pressure (siblings)	1.2	1.8	2.6	-1.2	0.9	1.6	-1.5
Forced vital capacity (FVC), Best measure	1.2	4.3	6.4	2.5	-1.7	-2.0	2.0
Body fat percentage	7.1	28.2	32.9	-5.7	5.1	5.5	-4.8
Leg fat percentage (right)	7.6	27.6	34.3	-5.9	4.8	5.5	-4.8
Arm fat-free mass (right)	0.7	3.8	6.8	-2.4	1.1	2.6	-1.1
Exposure to tobacco smoke outside home	1.3	1.7	2.6	-0.9	1.4	1.2	-1.6
Comparative body size at age 10	0.1	0.4	0.6	0.1	-0.8	-0.6	0.7
Number of full brothers	0.1	0.1	0.3	0.4	0.2	-0.5	0.2
Worry too long after embarrassment	1.2	2.1	2.8	1.5	-1.7	-1.4	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.2	6.2	-1.4	2.3	1.8	-2.5
Wheeze or whistling in the chest in last year	1.8	3.1	5.1	-2.2	1.7	1.6	-1.4
Number of children fathered	0.8	0.9	1.3	1.1	-0.4	-1.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.5	0.8	-0.9	-1.0	1.2
Age at first live birth	3.2	5.6	7.9	2.8	-1.9	-2.7	1.9
Pulse wave peak to peak time	1.2	1.4	2.9	1.3	-0.7	-1.7	0.8
Health satisfaction	0.3	0.4	1.3	-1.1	-0.3	0.6	0.0
Shortness of breath walking on level ground	1.7	2.0	3.8	-1.0	2.0	1.1	-1.4
Qualifications: College or University degree	3.6	11.2	12.0	3.4	-3.1	-3.4	3.5
Eye problems/disorders: None of the above	1.5	1.7	3.1	1.8	-0.8	-1.3	1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-1.0	0.9	0.5	-0.7
Emphysema/chronic bronchitis	3.1	3.5	4.3	-1.9	2.1	1.9	-1.6
Medication for pain relief, constipation, heartburn	7.2	12.3	15.8	3.9	-2.4	-4.0	3.5
Neck or shoulder pain in last month	3.9	5.5	6.8	-2.6	2.1	2.3	-2.3
Medication: Blood pressure	1.4	2.5	3.5	-1.5	1.9	1.5	-1.5
Angina (self-reported)	0.2	0.3	0.8	-0.2	0.2	0.3	-0.9
Migraine (self-reported)	0.4	0.5	0.7	-0.1	0.8	0.8	-0.8
Medication: Ibuprofen	0.3	0.4	0.6	-0.8	-0.7	0.8	0.1
Medication: Allopurinol	0.6	0.8	1.8	-1.1	0.3	1.3	-0.4
Medication: Omeprazole	1.4	1.6	2.0	-1.0	1.4	1.3	-1.4
Medication: Seretide 50 evohaler	0.5	0.6	0.7	0.6	0.7	-0.8	-0.9
Mean time to correctly identify matches	1.1	2.1	4.1	2.0	-0.4	-2.0	0.6
Heart disease (mother)	0.7	0.9	1.7	1.0	-0.7	-0.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	4.8	-1.9	1.3	2.2	-1.0
Whole body fat mass	6.8	28.4	34.0	-5.8	4.9	5.7	-4.8
Leg fat mass (right)	7.2	27.9	37.1	-6.1	4.6	5.8	-4.5
Arm predicted mass (right)	1.1	5.8	9.8	-2.8	1.7	3.1	-1.6
Pulse rate, automated reading	0.2	0.6	1.3	-0.5	0.9	-0.0	-1.1
Alcohol intake frequency.	0.1	0.1	0.3	0.4	-0.5	0.0	0.3
Comparative height size at age 10	0.1	0.4	1.3	1.1	0.2	-0.6	0.1
Number of full sisters	0.9	1.1	1.5	-0.8	1.0	1.2	-1.2
Suffer from ‘nerves’	2.9	4.6	5.6	2.4	-2.1	-2.3	1.7
Overall health rating	4.9	10.4	11.9	-3.2	3.0	3.5	-3.2
Chest pain or discomfort	1.5	2.2	3.2	-1.2	1.8	1.5	-1.4
Had major operations	0.9	1.1	1.7	-1.3	1.0	1.2	-0.2
Age at last live birth	4.6	6.7	9.1	3.0	-2.4	-2.7	2.2
Family relationship satisfaction	2.5	3.0	4.1	1.9	-1.5	-1.4	2.0
Leg pain on walking	6.8	8.6	9.9	-3.1	2.7	3.0	-2.9
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	2.3	-1.5	1.5	1.4	-1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.3	-1.1	0.1	1.2	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.5	-0.9	-0.8	0.8
Medication: Aspirin	1.6	2.1	2.4	-1.6	1.3	1.5	-1.5
Supplements: Vitamin C	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.2
Knee pain experienced in last month	5.8	9.0	13.8	-3.7	2.2	3.2	-2.7
Hypertension (Self-reported)	2.2	6.1	8.8	-3.0	1.9	2.6	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	0.1	1.5	0.4	-0.5
Illnesses of father: Heart disease	2.3	3.2	5.0	1.5	-2.0	-1.2	2.2
Illnesses of siblings: Diabetes	4.4	5.4	8.0	-2.0	2.8	2.4	-2.0
Smoking status: Previous	2.3	3.5	5.2	-2.3	0.8	2.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.0	0.1	-2.0	-0.2	1.4
Whole body fat-free mass	0.4	2.4	4.5	-1.9	0.9	2.1	-0.9
Leg fat-free mass (right)	0.5	2.6	5.0	-2.0	0.7	2.2	-0.8
Arm fat percentage (left)	5.9	23.4	27.7	-5.3	4.7	5.1	-4.3
Average weekly red wine intake	0.1	0.2	0.5	-0.2	0.7	0.3	-0.5
Handedness (chirality/laterality): Left-handed	1.5	1.8	4.6	2.1	-0.4	-1.5	0.5
Mood swings	0.9	1.6	1.7	-1.2	1.2	1.3	-1.3
Loneliness, isolation	1.5	2.0	3.0	1.7	-1.2	-1.2	1.4
Long-standing illness, disability or infirmity	4.5	6.9	8.1	-2.4	2.8	2.8	-2.5
Ever had bowel cancer screening	1.0	1.1	1.3	-1.1	1.1	1.0	-1.0
Diabetes diagnosed by doctor	8.8	14.5	18.7	-3.7	3.6	4.3	-3.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.2	0.7	-0.2	-0.5	1.1
Friendships satisfaction	0.2	0.2	0.6	-0.1	0.5	0.0	0.8
Qualifications: nursing, teaching	0.9	1.4	1.8	1.2	-1.0	-1.4	1.2
Commuting to job workplace: Walk	2.1	2.3	2.9	0.9	-1.7	-1.7	1.7
Eye problems/disorders: Cataract	0.4	0.5	0.7	-0.5	0.9	0.6	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.0	0.4	0.5	0.1
Medication for cholesterol	3.7	5.6	8.6	2.8	-1.9	-2.9	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.7	-0.8	0.7	1.3	-0.7
Back pain experienced in last month	4.7	6.8	10.3	-3.2	2.1	2.6	-2.4
Mineral and other dietary supplements	4.5	6.1	9.4	2.6	-1.8	-3.1	2.3
Breast cancer (self-reported)	0.6	0.7	2.2	-0.5	0.3	0.5	-1.5
Asthma (self-reported)	0.4	0.7	1.9	0.2	1.4	-0.7	-0.6
Osteoporosis (self-reported)	1.0	1.3	2.1	-0.5	1.2	1.1	-1.4
Osteoarthritis (self-reported)	1.7	2.2	4.2	-2.1	0.8	1.6	-1.1
Medication: Aspirin	2.7	3.5	4.6	-2.1	1.4	1.9	-2.0
Medication: Gliclazide	0.2	0.2	0.5	0.2	0.7	0.4	-0.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	0.4	0.4	-0.2
Smoking status: Current	0.4	0.6	1.4	-0.8	0.6	0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.8	1.9	-0.8	-1.6	1.2
Whole body water mass	0.4	2.4	4.4	-1.9	0.8	2.1	-0.9
Leg predicted mass (right)	0.5	2.5	4.9	-1.9	0.8	2.2	-0.9
Arm fat mass (left)	5.6	22.9	29.3	-5.4	4.3	5.2	-4.1
Number of self-reported non-cancer illnesses	4.7	8.2	11.4	-3.4	2.4	3.2	-2.4
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.2	-0.2	-0.6	0.0
Miserableness	0.2	0.4	1.2	1.1	0.4	-0.2	-0.2
Guilty feelings	0.1	0.2	0.6	0.2	-0.5	-0.2	0.8
Wears glasses or contact lenses	0.3	0.3	0.8	0.0	0.9	-0.4	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.6	-0.3	0.1	0.1
Hearing aid user	3.2	3.6	6.4	-2.5	1.2	1.9	-1.6
Mother’s age at death	2.1	2.7	5.8	1.8	-1.2	-2.4	0.1
Financial situation satisfaction	2.4	2.9	5.9	-0.9	2.4	1.6	-1.5
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.0	-0.1	-1.0	0.0	0.3
Commuting to job workplace: Public transport	1.5	1.8	3.2	1.6	-0.9	-1.8	0.6
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	-1.0	-1.4	0.2	0.6
Medication: Blood pressure	0.7	1.3	1.8	-1.1	1.3	1.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	0.2	-1.4	-0.5	1.3
Supplements: Fish oil (including cod liver oil)	1.7	2.3	3.9	-1.6	0.8	2.0	-1.4
High cholesterol (Self-reported)	1.7	3.1	4.9	-2.2	1.4	2.1	-1.1
Medication: Bendroflumethiazide	1.5	2.2	3.8	-2.0	1.1	1.6	-1.2
Medication: Paracetamol	1.8	2.7	5.2	-2.3	0.3	1.9	-1.4
Medication: Lisinopril	0.9	1.2	3.5	-1.9	0.5	0.9	-0.7
Medication: Atorvastatin	0.3	0.4	0.6	-0.5	0.7	0.5	-0.7
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.1	-0.6	0.2	0.2
Alcohol drinker status: Never	1.1	1.4	3.0	-1.4	0.1	1.7	-0.7
Ever smoked	0.1	0.1	0.4	-0.2	-0.6	-0.3	-0.1
Basal metabolic rate	0.9	4.9	7.7	-2.7	1.5	2.8	-1.5
Leg fat percentage (left)	6.5	23.5	26.9	-5.2	4.6	4.9	-4.7
Arm fat-free mass (left)	1.0	4.9	7.6	-2.6	1.6	2.8	-1.7
Number of operations (self-reported)	0.8	1.2	2.5	-1.6	0.0	1.4	0.5
Average weekly beer plus cider intake	0.3	0.5	0.9	-0.9	-0.4	0.8	0.4
Irritability	0.0	0.1	0.1	-0.4	-0.3	-0.1	-0.1
Risk taking	0.5	0.8	1.6	0.2	-1.0	-0.7	1.3
Ever had prostate specific antigen (PSA) test	1.7	2.0	2.4	-1.5	1.4	1.2	-1.6
Fractured/broken bones in last 5 years	3.2	4.2	7.6	-2.3	1.1	2.8	-1.6
Age started oral contraceptive pill	0.7	0.9	1.7	1.3	-0.8	-0.8	0.8
Diastolic blood pressure, automated reading	0.2	0.8	2.0	0.8	-0.2	-0.7	1.4
Ever depressed for a whole week	0.1	0.1	0.2	-0.1	-0.4	0.3	0.2
Unable to work because of sickness or disability	1.3	1.7	2.7	-0.8	1.6	1.1	-1.5
Commuting to job workplace: Cycle	0.3	0.3	0.7	0.3	-0.7	-0.1	0.8
Myopia	0.3	0.5	1.1	-1.1	0.2	0.6	-0.6
Vascular/heart problems diagnosed by doctor	1.8	5.0	7.2	2.7	-1.8	-2.4	2.0
Cholesterol lowering medication	2.3	3.3	6.0	-1.8	1.7	2.4	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.3	-0.6	0.9	0.9	-1.1
Pain experienced in last month	0.9	1.6	4.2	2.1	-0.1	-1.1	0.9
Supplements: Calcium	1.4	1.6	3.0	-1.5	0.4	1.7	-1.0
Basal cell carcinoma (self-reported)	1.7	2.0	2.6	1.2	-1.5	-1.3	1.6
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.3	-1.2	0.8	1.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	1.8	1.4	-0.6	-0.9	1.1
Heart disease (siblings)	0.4	0.5	1.0	-0.6	-0.3	0.7	1.0
Alcohol drinker status: Previous	1.4	1.6	2.4	-1.3	0.9	1.6	-1.3
Pack years of smoking	1.5	2.3	4.4	-1.3	1.2	1.2	-2.1
Impedance of whole body	0.1	0.7	1.6	1.1	-0.1	-1.2	0.5
Leg fat mass (left)	6.7	26.0	33.1	-5.8	4.5	5.5	-4.5
Arm predicted mass (left)	0.8	3.9	6.4	-2.2	1.5	2.5	-1.5