Hub : Genes

TUFT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.4080	0.1250	2.4e-03	-0.013	NA	0.226	NA	0.064	9.6e-01	NA	4.9e-06	NA	1.4e-02
2	METSIM	Adipose	0.0602	0.0206	3.7e-05	0.040	0.023	0.031	0.025	0.032	1.1e-06	1.6e-04	1.6e-05	9.3e-05	1.4e-05
3	YFS	Blood	0.0856	0.0289	3.6e-06	0.000	0.023	0.018	0.023	0.002	4.9e-01	4.2e-08	7.9e-07	2.7e-08	7.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.1	1.8	4.7	2.2	0.1	-0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	2.2	1.5	0.4	-1.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.7	0.1	-0.2
Depression (Nagel 2018)	0.3	0.5	0.9	-0.7	-0.9	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	-0.7	1.2	0.3
Neuroticism (Nagel 2018)	0.4	1.0	2.0	-1.4	1.0	0.0
Schizophrenia (2018)	0.3	0.5	1.3	0.4	0.4	-1.1
Schizophrenia vs Biploar Disorder	1.8	2.4	5.3	-1.3	-0.3	2.3
Worry (Nagel 2018)	1.1	2.3	4.0	-2.0	1.3	1.1
Alzheimer’s Disease (in mother)	0.9	1.1	1.9	1.4	-0.2	-1.1
Alzheimer’s Disease (in father)	2.4	2.6	7.0	-2.6	0.8	0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	-0.4	-0.1	0.1
Crohns Disease (2017)	2.1	4.6	13.4	-0.4	3.7	0.4
Irritable Bowel Disease (IBD)	3.0	7.0	14.0	-1.3	3.7	2.3
Ulcerative Colitis (UC)	2.8	5.2	7.9	-1.2	2.5	2.8
Major Depression (MDD)	1.2	1.5	4.4	-2.1	-0.1	0.2
Reaction Time	0.0	0.1	0.2	0.1	0.4	-0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.1	0.3	0.4
Breast Cancer	0.6	1.4	3.5	0.8	-1.9	-0.4
Ovarian Cancer	0.3	0.5	0.9	-0.5	1.0	-0.5
Prostate Cancer	1.6	2.3	3.7	1.9	-1.7	0.6
Age at First Birth	1.1	1.6	3.0	1.3	-1.7	-0.3
Bipolar Disorder (2011)	0.2	0.2	0.4	0.6	-0.3	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.7	-0.8	0.1
Coronary Artery Disease (CAD)	1.4	1.7	3.5	-1.3	1.9	-0.2
Crohns Disease (2012)	1.4	2.2	3.6	-0.8	1.6	1.9
Mean Putamen Volume	2.4	2.7	7.4	-2.7	0.8	0.3
Fasting Glucose	0.2	0.3	0.5	-0.3	-0.7	-0.5
HbA1C	0.9	1.0	2.1	-0.1	-1.4	1.0
HDL Cholesterol	0.7	1.2	1.9	1.2	-1.4	0.5
LDL Cholesterol	0.7	1.0	2.8	-1.7	0.5	-0.4
Lupus	1.1	1.6	2.4	1.5	-1.6	0.1
Neuroticism (2016)	0.5	0.7	1.7	-0.6	1.3	-0.2
Primary Biliary Cirrhosis	0.8	1.1	2.9	0.7	-1.7	0.1
Rheumatoid Arthritis	0.4	0.6	1.6	-0.3	-1.3	0.1
Schizophrenia (2014)	0.3	0.8	2.0	0.1	0.5	-1.4
Triglycerides	0.2	0.3	0.9	-0.3	-0.9	-0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.1	-0.4	1.8	-0.7
Ulcerative Colitis	3.4	4.9	5.7	-1.9	2.3	2.4
Blood Eosinophil Count	1.4	10.8	15.7	-4.0	-2.8	2.9
Blood Platelet Count	0.4	4.9	9.0	3.0	0.0	-2.4
Blood Red Count	0.7	6.3	12.3	-3.5	-0.3	-2.6
Blood White Count	0.2	1.7	4.0	-2.0	0.7	-0.8
Heel T-Score	1.2	9.4	15.2	1.0	3.9	-3.5
BMI	0.3	1.6	4.2	-2.0	0.7	-0.1
Height	0.2	4.7	12.5	0.3	1.2	3.5
Waist Hip Ratio (WHR)	1.1	5.1	7.6	-2.8	2.5	1.1
Systolic Blood Pressure	0.1	0.4	0.6	-0.0	0.8	-0.7
Smoking Status	0.2	0.6	0.8	-0.9	0.8	0.5
Allergy or Eczema	4.0	10.6	19.0	-1.9	3.0	4.4
Cardiovascular Disease	1.2	4.1	6.2	-2.5	1.8	1.7
Hypothyroidism (self reported)	0.6	1.4	2.1	-1.4	1.5	0.1
Respiratory disease	1.1	2.3	4.4	-1.0	1.3	2.1
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.9	-2.2	0.4	-0.2
Lung FEV1/FVC ratio	1.1	5.4	8.0	-2.8	0.4	-2.8
Lung FVC	0.5	2.6	6.0	2.5	-1.3	0.5
Neuroticism	0.9	2.2	2.7	-1.2	1.6	-1.6
Chronotype (morning person)	0.9	2.0	3.5	-1.5	1.9	-0.3
Hair Pigment	0.4	10.6	26.2	-2.2	-1.0	5.1
Tanning	0.1	1.3	3.6	1.9	0.4	0.2
Hand grip strength (left)	0.5	1.2	1.5	1.0	1.1	1.2
Number of treatments/medications taken	2.2	4.0	10.5	-1.0	3.2	-0.7
Average weekly spirits intake	0.4	0.6	1.4	1.2	-0.1	-0.5
Sensitivity / hurt feelings	0.6	1.1	1.9	-0.1	1.1	-1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.8	-0.8	0.0
Hearing difficulty/problems: Yes	0.5	0.7	1.0	0.9	1.0	-0.7
Relative age of first facial hair	1.3	2.6	7.2	0.3	-0.7	2.7
Other serious medical condition/disability diagnosed by doctor	3.2	4.1	9.2	-1.1	3.0	1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	1.1	0.5	-0.2
Ever had hysterectomy (womb removed)	1.5	1.6	4.2	-0.5	-0.7	-2.0
Systolic blood pressure, automated reading	0.4	1.2	2.9	0.5	0.6	-1.7
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	6.2	-2.5	1.8	-1.5
Angina	1.0	1.3	2.8	0.4	0.9	-1.7
Medication for hormone replacement therapy	1.5	1.7	3.5	1.9	-0.8	1.0
Vitamin and mineral supplements	0.6	0.8	2.0	1.4	-0.2	-0.4
Supplements: Zinc	0.7	0.8	1.2	-0.5	0.9	-1.1
Medication: Co-codamol	0.1	0.1	0.2	0.1	0.4	-0.4
Medication: Metformin	1.7	2.4	3.9	-1.6	2.0	-1.0
Diabetes (father)	0.3	0.3	0.6	-0.7	0.2	0.8
Diabetes (mother)	0.4	0.5	1.4	-0.2	0.2	-1.2
Severe depression (siblings)	1.9	2.2	3.5	-1.3	1.9	-1.1
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	0.5	-0.3
Impedance of leg (right)	0.4	2.1	4.1	-2.0	1.2	-0.8
Leg fat-free mass (left)	0.2	0.8	1.5	-0.4	0.9	1.2
Trunk fat percentage	1.1	4.4	8.1	-2.1	2.8	-0.9
Hand grip strength (right)	0.3	0.8	0.9	0.9	1.0	0.8
Townsend deprivation index at recruitment	2.0	2.8	5.7	-1.2	2.4	-1.1
Current tobacco smoking	1.3	2.1	3.8	1.9	1.6	0.0
Average weekly fortified wine intake	0.4	0.5	1.4	-0.3	-0.1	1.2
Maternal smoking around birth	1.3	1.9	3.5	-1.9	1.4	0.5
Fed-up feelings	0.4	0.7	1.8	-0.1	1.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	1.8	-1.2	-0.1	1.4
Relative age voice broke	1.3	2.0	4.2	-0.9	-0.9	2.1
Taking other prescription medications	2.1	3.3	7.3	-1.6	2.7	-0.2
Age when periods started (menarche)	1.4	3.5	9.0	3.0	0.9	0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.3	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	0.8	0.9	0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.1	-2.0	0.7	1.4
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-0.9	0.2	1.2
Serious illness, injury or assault to yourself	1.1	1.4	2.5	-1.6	1.2	0.5
High blood pressure	1.6	4.4	8.9	-1.6	3.0	1.3
Hayfever, allergic rhinitis or eczema	4.3	9.3	21.2	-0.6	2.5	4.6
Multivitamins +/- minerals	0.2	0.2	0.5	-0.7	0.0	-0.4
Stomach or abdominal pain in last month	0.5	0.6	1.8	-1.3	-0.1	0.2
Supplements: Glucosamine	1.5	1.9	5.7	-0.2	-0.1	2.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.3	-1.2	-0.7	1.0
Medication: Atenolol	0.5	0.6	1.1	0.2	0.7	-1.0
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.8	0.2	-0.5
Sitting height	0.5	3.7	9.0	1.0	1.1	3.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	1.0	0.8	-0.3
High blood pressure (mother)	1.0	1.3	2.7	-1.1	1.6	0.2
Body mass index (BMI)	0.2	0.7	1.1	-1.0	1.0	-0.3
Impedance of leg (left)	0.2	0.9	1.3	-1.2	1.1	-0.4
Leg predicted mass (left)	0.1	0.8	1.5	-0.3	0.9	1.2
Trunk fat mass	0.8	3.5	6.4	-2.0	2.5	-0.3
Waist circumference	0.8	2.9	4.5	-2.1	2.1	-0.1
Number of incorrect matches in round	0.4	0.7	2.1	0.1	-1.4	-0.1
Past tobacco smoking	1.3	2.4	6.0	2.5	-0.4	-1.0
Alcohol usually taken with meals	2.5	4.1	5.1	2.1	-1.6	2.2
Nervous feelings	0.6	1.2	1.8	-1.3	0.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	0.4	-0.2	0.3
Hearing difficulty/problems with background noise	0.6	0.9	1.6	1.0	1.3	-0.4
Hair/balding pattern: Pattern 2	1.2	1.5	1.7	-1.3	-1.2	1.1
Had menopause	1.0	1.2	3.1	-0.1	0.7	-1.8
Had other major operations	1.3	1.6	4.2	0.4	-0.5	-2.0
Forced vital capacity (FVC)	1.0	4.0	9.0	1.7	0.3	3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	0.1	1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	-0.6	0.4	-0.2
Qualifications: None of the above	1.0	2.1	4.7	1.2	0.2	-2.2
Financial difficulties in last 2 years	1.1	1.4	2.3	-1.5	1.4	-0.2
Mouth/teeth dental problems	0.2	0.2	0.4	-0.5	0.2	0.6
Heart attack	0.2	0.2	0.3	-0.4	0.5	-0.3
Allergy	3.5	8.0	15.0	1.3	-2.7	-3.9
Pain all over the body in last month	2.5	2.7	4.2	-2.1	1.7	-1.0
Diabetes (self-reported)	2.9	4.6	10.4	-3.2	1.4	-1.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	4.7	-0.6	0.5	2.2
Medication: Ramipril	1.9	2.4	4.3	-1.7	2.1	-0.2
Medication: Simvastatin	2.9	4.2	8.8	-3.0	1.3	-1.5
Fluid intelligence score	0.2	0.3	0.5	0.5	0.7	0.5
Illnesses of siblings	0.4	0.6	1.6	-0.1	-0.5	-1.3
Neuroticism score	0.7	1.5	2.5	-1.4	1.6	-0.2
Weight	0.3	1.4	2.4	-1.2	1.6	0.6
Impedance of arm (right)	0.6	2.8	7.7	-0.4	2.8	-0.7
Arm fat percentage (right)	0.8	3.2	6.7	-1.6	2.6	-0.4
Trunk fat-free mass	0.2	1.2	3.3	-0.0	-0.4	1.8
Hip circumference	0.3	1.3	2.6	-0.7	1.6	-0.9
Time employed in main current job	0.1	0.1	0.2	0.4	-0.3	0.4
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-0.2	0.7	0.9
Father’s age at death	0.7	0.9	1.6	-0.8	-0.7	1.3
Worrier / anxious feelings	0.4	0.8	1.6	-0.7	0.5	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	0.9	-0.8	-0.9	0.9
Falls in the last year	0.6	0.9	1.7	0.8	1.3	0.4
Hair/balding pattern: Pattern 3	2.2	3.2	7.1	1.6	0.3	-2.7
Number of live births	0.6	0.8	2.4	0.2	-1.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	3.8	0.9	0.2	2.0
Pulse rate	1.8	3.0	7.1	0.3	2.7	1.4
Happiness	0.4	0.5	1.2	-0.2	-1.1	-0.4
Noisy workplace	0.7	0.8	1.5	-0.8	1.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.4	0.1	-0.1	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.9	-1.6	1.7	-0.2
Mouth/teeth dental problems: Dentures	2.4	4.0	11.3	3.4	-0.6	-0.6
Asthma	2.2	4.3	4.7	-2.1	2.2	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	6.0	-0.3	0.2	2.4
Medication: Cholesterol lowering	1.1	1.7	2.5	-1.4	1.6	-0.7
Depression (self-reported)	1.7	2.0	3.3	1.8	1.6	-0.6
Medication: Lansoprazole	1.9	2.1	3.5	-0.3	-1.9	1.7
Prospective memory result	3.8	4.7	11.7	1.2	-1.0	-3.4
Lung cancer (father)	1.6	1.9	2.6	0.8	1.6	-1.6
Illnesses of mother	0.6	0.7	1.6	0.3	-1.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.1	0.8	-0.0	1.4
Pulse wave Arterial Stiffness index	1.4	1.7	3.1	0.1	-1.8	1.4
Impedance of arm (left)	0.7	3.2	7.3	-0.9	2.7	-1.2
Arm fat mass (right)	0.5	2.1	4.5	-1.3	2.1	-0.1
Trunk predicted mass	0.2	1.3	3.6	-0.0	-0.4	1.9
Standing height	0.2	1.9	3.2	-0.3	1.5	1.8
Length of working week for main job	0.6	0.7	1.8	-1.4	-0.1	0.4
Exposure to tobacco smoke at home	1.1	1.3	1.9	-1.4	1.2	-0.6
Breastfed as a baby	0.9	1.1	2.1	0.8	-0.7	-1.4
Tense / ‘highly strung’	0.5	0.8	1.9	-1.4	0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.4	-1.2	1.9	0.7
Hair/balding pattern: Pattern 4	1.2	3.0	4.0	2.0	1.1	-2.0
Birth weight of first child	1.2	2.2	4.8	-1.2	0.4	2.2
Peak expiratory flow (PEF)	0.3	0.8	1.7	-0.4	0.7	1.3
Pulse wave reflection index	1.5	1.8	4.0	-2.0	-0.9	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.6	0.4	0.1	-0.8
Loud music exposure frequency	0.7	0.8	1.4	-0.9	-1.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.4	-0.8	0.2	1.2
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.7	-1.9	-0.7	1.2
Blood clot in the leg (DVT)	0.9	1.2	2.8	-0.8	1.7	-0.1
Medication: Paracetamol	2.0	3.4	6.1	-2.5	0.2	2.0
Headache pain in last month	0.6	1.1	3.2	0.2	-0.2	1.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.1	2.0	-1.3	-1.2
Glaucoma (self-reported)	2.1	2.4	6.9	-2.6	0.2	0.6
Gout (self-reported)	2.4	3.2	4.9	-2.2	0.8	2.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	1.6	-1.2	1.3	-0.1
Medication: Amlodipine	0.4	0.5	1.5	-0.3	1.2	0.1
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.3	-1.1	2.1	1.1
Birth weight	0.5	1.2	3.4	0.2	0.2	1.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.3	-0.0	-0.5
High blood pressure (siblings)	0.6	0.9	2.6	-0.2	0.3	1.6
Forced vital capacity (FVC), Best measure	0.6	2.2	5.3	1.0	0.4	2.3
Body fat percentage	1.0	4.1	6.8	-2.2	2.6	-0.8
Leg fat percentage (right)	1.3	4.5	8.3	-2.9	2.1	-1.0
Arm fat-free mass (right)	0.2	0.9	1.9	-0.8	-0.5	1.4
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-1.3	0.7	-0.6
Comparative body size at age 10	0.7	1.8	5.0	-0.2	0.7	-2.2
Number of full brothers	3.7	4.6	8.5	-1.9	2.9	-1.3
Worry too long after embarrassment	1.0	1.6	2.7	-1.6	1.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	8.0	-0.2	2.8	0.5
Wheeze or whistling in the chest in last year	0.7	1.2	2.7	-0.9	1.6	-0.2
Number of children fathered	1.0	1.2	2.3	-0.9	0.6	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.4	0.4	0.6
Age at first live birth	0.8	1.4	2.6	-0.6	1.6	1.2
Pulse wave peak to peak time	1.8	2.1	4.1	-0.2	2.0	-1.5
Health satisfaction	0.5	0.7	1.5	0.5	-0.5	1.2
Shortness of breath walking on level ground	0.8	1.0	2.2	-1.5	-0.2	0.8
Qualifications: College or University degree	0.9	2.8	7.5	0.7	0.6	2.7
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.0	-0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-1.1	0.3	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.1	-0.4	-0.3
Medication for pain relief, constipation, heartburn	2.0	3.5	5.3	2.3	-2.3	-0.2
Neck or shoulder pain in last month	1.9	2.8	5.1	0.9	-1.6	2.3
Medication: Blood pressure	1.6	2.9	4.2	-1.6	1.4	2.1
Angina (self-reported)	1.1	1.5	3.4	0.2	1.0	-1.8
Migraine (self-reported)	1.2	1.5	4.3	-0.5	-2.1	0.2
Medication: Ibuprofen	1.5	1.8	5.1	-0.0	0.4	2.2
Medication: Allopurinol	2.7	3.6	5.5	-2.4	1.3	1.9
Medication: Omeprazole	3.1	3.7	7.0	-1.4	2.6	-1.4
Medication: Seretide 50 evohaler	1.3	1.5	2.3	-1.5	-0.0	1.4
Mean time to correctly identify matches	0.0	0.0	0.1	-0.1	-0.3	0.1
Heart disease (mother)	0.8	1.0	1.5	-1.2	0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	0.7	0.1	0.1
Whole body fat mass	0.7	2.7	4.9	-1.8	2.2	-0.0
Leg fat mass (right)	0.8	3.2	5.2	-2.3	2.1	-0.1
Arm predicted mass (right)	0.2	0.8	1.9	-0.4	-0.7	1.4
Pulse rate, automated reading	0.9	3.0	8.1	-0.9	2.8	0.4
Alcohol intake frequency.	0.4	0.9	1.6	-0.4	-0.9	-1.3
Comparative height size at age 10	0.5	2.9	4.4	-1.9	2.1	-0.9
Number of full sisters	0.2	0.3	0.3	0.5	0.5	-0.5
Suffer from ‘nerves’	0.2	0.2	0.5	-0.5	0.7	-0.0
Overall health rating	1.1	2.3	3.3	-1.1	1.8	-1.5
Chest pain or discomfort	2.1	3.0	5.2	-2.3	1.9	-0.4
Had major operations	0.9	1.0	2.9	-1.7	-0.3	0.4
Age at last live birth	1.6	2.4	4.2	-1.7	-0.0	2.1
Family relationship satisfaction	0.6	0.8	1.5	-0.5	0.7	1.2
Leg pain on walking	0.0	0.0	0.1	-0.3	-0.0	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	-0.7	-1.1	0.1
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.0	-1.7	1.2	-0.8
Illness, injury, bereavement, stress in last 2 years	4.8	5.9	14.3	3.8	-1.8	0.1
Medication: Aspirin	5.0	6.6	11.1	-3.3	1.9	-2.3
Supplements: Vitamin C	1.3	1.6	2.6	-1.6	1.4	0.4
Knee pain experienced in last month	0.8	1.3	2.2	1.0	0.8	1.5
Hypertension (Self-reported)	1.2	3.3	6.8	-1.2	2.6	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.4	-1.2	-1.3	1.5
Illnesses of father: Heart disease	0.6	0.8	1.5	1.0	1.2	-0.0
Illnesses of siblings: Diabetes	2.9	3.5	9.4	0.5	3.1	-0.9
Smoking status: Previous	1.6	2.4	6.7	-2.6	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	6.5	-2.0	1.3	2.5
Whole body fat-free mass	0.1	0.8	2.4	-0.1	-0.0	1.6
Leg fat-free mass (right)	0.2	1.0	2.4	0.3	0.8	1.5
Arm fat percentage (left)	0.8	3.3	6.2	-1.8	2.5	-0.6
Average weekly red wine intake	1.6	2.4	6.9	2.6	0.2	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.6	0.6	1.3	-0.4
Mood swings	0.4	0.7	1.6	0.6	0.4	-1.3
Loneliness, isolation	0.3	0.5	1.1	0.0	1.1	-0.5
Long-standing illness, disability or infirmity	2.7	4.2	8.3	-1.7	2.9	1.2
Ever had bowel cancer screening	0.5	0.6	1.4	-0.5	0.3	-1.2
Diabetes diagnosed by doctor	2.0	3.2	6.0	-2.5	1.2	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	4.1	-1.4	2.0	1.5
Friendships satisfaction	0.9	1.1	2.8	-0.6	-0.3	1.7
Qualifications: nursing, teaching	0.5	0.7	2.1	0.3	-0.1	1.5
Commuting to job workplace: Walk	1.4	1.5	2.0	-1.4	1.2	-1.0
Eye problems/disorders: Cataract	0.8	0.9	2.2	1.5	-0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.1	-0.0	-0.3
Medication for cholesterol	0.3	0.5	0.8	-0.9	-0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.0	1.1	1.7	-0.8
Back pain experienced in last month	0.5	0.7	1.4	1.2	-0.1	0.8
Mineral and other dietary supplements	0.9	1.2	2.6	1.6	-0.6	-0.8
Breast cancer (self-reported)	0.7	0.8	1.2	-0.5	1.1	-1.0
Asthma (self-reported)	2.0	4.0	4.6	-1.8	2.0	2.1
Osteoporosis (self-reported)	0.5	0.7	1.8	0.4	-0.3	1.3
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.0	-0.6	0.8
Medication: Aspirin	4.7	6.1	9.0	-2.5	1.8	-3.0
Medication: Gliclazide	1.2	1.3	3.2	-0.6	0.6	-1.8
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	-0.6	-0.9	-0.6
Smoking status: Current	1.1	1.8	3.6	1.9	1.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	0.7	-1.4	-0.3
Whole body water mass	0.1	0.8	2.5	-0.1	-0.1	1.6
Leg predicted mass (right)	0.2	1.0	2.5	0.3	0.7	1.6
Arm fat mass (left)	0.5	2.1	3.9	-1.5	2.0	-0.1
Number of self-reported non-cancer illnesses	1.3	2.3	2.8	-1.3	1.5	1.7
Average weekly champagne plus white wine intake	0.4	0.6	0.7	0.9	-0.4	0.9
Miserableness	0.5	0.9	2.1	-0.6	1.4	-0.4
Guilty feelings	2.3	3.5	8.1	-2.8	1.0	1.2
Wears glasses or contact lenses	0.8	0.9	2.4	-0.1	-0.6	1.6
Ever taken oral contraceptive pill	0.7	0.7	2.0	-0.4	1.4	0.2
Hearing aid user	1.2	1.4	4.1	0.1	-0.1	2.0
Mother’s age at death	0.1	0.1	0.2	0.2	-0.5	0.0
Financial situation satisfaction	1.3	1.6	3.4	-1.8	0.2	1.2
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.8	0.9	0.1	-1.4
Commuting to job workplace: Public transport	1.1	1.3	3.1	1.8	0.1	0.9
Eye problems/disorders: Glaucoma	1.7	2.0	5.1	-2.3	0.6	0.8
Medication: Blood pressure	1.2	2.3	3.7	0.3	1.9	-1.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	-0.5	0.5	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.8	-1.3	0.5	0.7
High cholesterol (Self-reported)	0.3	0.5	1.6	-1.3	0.0	0.0
Medication: Bendroflumethiazide	0.8	1.1	1.9	-0.7	1.4	1.0
Medication: Paracetamol	1.4	2.2	4.6	-2.1	0.3	1.4
Medication: Lisinopril	1.6	2.1	3.9	2.0	1.4	-0.6
Medication: Atorvastatin	0.5	0.6	1.2	0.5	1.1	-0.6
Illnesses of father: High blood pressure	0.9	1.1	2.6	-1.6	0.3	0.7
Alcohol drinker status: Never	1.8	2.2	4.5	0.4	-2.1	-1.4
Ever smoked	0.4	0.7	1.8	-1.4	0.3	0.5
Basal metabolic rate	0.2	0.9	2.2	-0.5	0.5	1.5
Leg fat percentage (left)	0.8	3.0	4.7	-2.2	2.0	-0.6
Arm fat-free mass (left)	0.1	0.7	1.6	-0.5	-0.3	1.3
Number of operations (self-reported)	0.5	0.8	1.5	0.1	-1.2	-0.9
Average weekly beer plus cider intake	0.6	0.9	1.3	-1.2	1.1	-0.5
Irritability	0.3	0.5	1.0	-1.0	-0.5	-0.6
Risk taking	0.4	0.6	1.2	1.1	0.7	-0.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.4	-0.8	1.2	1.0
Fractured/broken bones in last 5 years	1.3	1.7	2.2	-1.5	1.4	0.9
Age started oral contraceptive pill	0.9	1.1	2.5	0.6	-1.6	-0.7
Diastolic blood pressure, automated reading	0.3	0.9	1.8	-0.9	1.3	0.4
Ever depressed for a whole week	2.6	3.2	5.0	-1.9	2.2	-0.9
Unable to work because of sickness or disability	3.4	4.3	9.4	-1.9	3.1	-0.2
Commuting to job workplace: Cycle	1.3	1.5	2.5	-0.7	1.6	1.3
Myopia	0.7	1.0	1.3	1.1	-1.0	-0.8
Vascular/heart problems diagnosed by doctor	1.9	5.0	11.2	2.0	-3.4	-0.2
Cholesterol lowering medication	0.7	1.0	2.2	-1.5	0.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	8.0	-0.5	2.8	-1.2
Pain experienced in last month	1.3	2.2	4.0	-1.2	1.1	-2.0
Supplements: Calcium	0.6	0.7	1.3	1.1	0.8	-0.4
Basal cell carcinoma (self-reported)	0.9	1.0	3.1	-0.1	1.8	-0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.7	0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.4	-0.9	1.5	0.0
Heart disease (siblings)	0.3	0.4	1.1	-1.0	0.0	-0.4
Alcohol drinker status: Previous	1.6	1.8	3.3	0.9	1.8	1.1
Pack years of smoking	0.2	0.3	0.4	0.6	0.2	-0.6
Impedance of whole body	0.3	1.7	3.5	-0.9	1.9	-0.9
Leg fat mass (left)	0.6	2.4	3.9	-1.8	2.0	0.1
Arm predicted mass (left)	0.1	0.6	1.6	-0.4	-0.1	1.2