Hub : Genes

TUFT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hypothalamus 0.4080 0.1250 2.4e-03 -0.013 NA 0.226 NA 0.064 9.6e-01 NA 4.9e-06 NA 1.4e-02
2 METSIM Adipose 0.0602 0.0206 3.7e-05 0.040 0.023 0.031 0.025 0.032 1.1e-06 1.6e-04 1.6e-05 9.3e-05 1.4e-05
3 YFS Blood 0.0856 0.0289 3.6e-06 0.000 0.023 0.018 0.023 0.002 4.9e-01 4.2e-08 7.9e-07 2.7e-08 7.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.1 1.8 4.7 2.2 0.1 -0.8
Bipolar Disorder or Schizophrenia 0.5 1.2 2.2 1.5 0.4 -1.1
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 0.7 0.1 -0.2
Depression (Nagel 2018) 0.3 0.5 0.9 -0.7 -0.9 0.3
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 -0.7 1.2 0.3
Neuroticism (Nagel 2018) 0.4 1.0 2.0 -1.4 1.0 0.0
Schizophrenia (2018) 0.3 0.5 1.3 0.4 0.4 -1.1
Schizophrenia vs Biploar Disorder 1.8 2.4 5.3 -1.3 -0.3 2.3
Worry (Nagel 2018) 1.1 2.3 4.0 -2.0 1.3 1.1
Alzheimer’s Disease (in mother) 0.9 1.1 1.9 1.4 -0.2 -1.1
Alzheimer’s Disease (in father) 2.4 2.6 7.0 -2.6 0.8 0.2
Alzheimer’s Disease (including proxy) 0.0 0.1 0.2 -0.4 -0.1 0.1
Crohns Disease (2017) 2.1 4.6 13.4 -0.4 3.7 0.4
Irritable Bowel Disease (IBD) 3.0 7.0 14.0 -1.3 3.7 2.3
Ulcerative Colitis (UC) 2.8 5.2 7.9 -1.2 2.5 2.8
Major Depression (MDD) 1.2 1.5 4.4 -2.1 -0.1 0.2
Reaction Time 0.0 0.1 0.2 0.1 0.4 -0.0
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.1 0.3 0.4
Breast Cancer 0.6 1.4 3.5 0.8 -1.9 -0.4
Ovarian Cancer 0.3 0.5 0.9 -0.5 1.0 -0.5
Prostate Cancer 1.6 2.3 3.7 1.9 -1.7 0.6
Age at First Birth 1.1 1.6 3.0 1.3 -1.7 -0.3
Bipolar Disorder (2011) 0.2 0.2 0.4 0.6 -0.3 0.4
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 -0.7 -0.8 0.1
Coronary Artery Disease (CAD) 1.4 1.7 3.5 -1.3 1.9 -0.2
Crohns Disease (2012) 1.4 2.2 3.6 -0.8 1.6 1.9
Mean Putamen Volume 2.4 2.7 7.4 -2.7 0.8 0.3
Fasting Glucose 0.2 0.3 0.5 -0.3 -0.7 -0.5
HbA1C 0.9 1.0 2.1 -0.1 -1.4 1.0
HDL Cholesterol 0.7 1.2 1.9 1.2 -1.4 0.5
LDL Cholesterol 0.7 1.0 2.8 -1.7 0.5 -0.4
Lupus 1.1 1.6 2.4 1.5 -1.6 0.1
Neuroticism (2016) 0.5 0.7 1.7 -0.6 1.3 -0.2
Primary Biliary Cirrhosis 0.8 1.1 2.9 0.7 -1.7 0.1
Rheumatoid Arthritis 0.4 0.6 1.6 -0.3 -1.3 0.1
Schizophrenia (2014) 0.3 0.8 2.0 0.1 0.5 -1.4
Triglycerides 0.2 0.3 0.9 -0.3 -0.9 -0.2
Type 2 Diabetes (T2D) (2012) 1.1 1.2 3.1 -0.4 1.8 -0.7
Ulcerative Colitis 3.4 4.9 5.7 -1.9 2.3 2.4
Blood Eosinophil Count 1.4 10.8 15.7 -4.0 -2.8 2.9
Blood Platelet Count 0.4 4.9 9.0 3.0 0.0 -2.4
Blood Red Count 0.7 6.3 12.3 -3.5 -0.3 -2.6
Blood White Count 0.2 1.7 4.0 -2.0 0.7 -0.8
Heel T-Score 1.2 9.4 15.2 1.0 3.9 -3.5
BMI 0.3 1.6 4.2 -2.0 0.7 -0.1
Height 0.2 4.7 12.5 0.3 1.2 3.5
Waist Hip Ratio (WHR) 1.1 5.1 7.6 -2.8 2.5 1.1
Systolic Blood Pressure 0.1 0.4 0.6 -0.0 0.8 -0.7
Smoking Status 0.2 0.6 0.8 -0.9 0.8 0.5
Allergy or Eczema 4.0 10.6 19.0 -1.9 3.0 4.4
Cardiovascular Disease 1.2 4.1 6.2 -2.5 1.8 1.7
Hypothyroidism (self reported) 0.6 1.4 2.1 -1.4 1.5 0.1
Respiratory disease 1.1 2.3 4.4 -1.0 1.3 2.1
Type 2 Diabetes (T2D) (2018) 0.9 1.7 4.9 -2.2 0.4 -0.2
Lung FEV1/FVC ratio 1.1 5.4 8.0 -2.8 0.4 -2.8
Lung FVC 0.5 2.6 6.0 2.5 -1.3 0.5
Neuroticism 0.9 2.2 2.7 -1.2 1.6 -1.6
Chronotype (morning person) 0.9 2.0 3.5 -1.5 1.9 -0.3
Hair Pigment 0.4 10.6 26.2 -2.2 -1.0 5.1
Tanning 0.1 1.3 3.6 1.9 0.4 0.2
Hand grip strength (left) 0.5 1.2 1.5 1.0 1.1 1.2
Number of treatments/medications taken 2.2 4.0 10.5 -1.0 3.2 -0.7
Average weekly spirits intake 0.4 0.6 1.4 1.2 -0.1 -0.5
Sensitivity / hurt feelings 0.6 1.1 1.9 -0.1 1.1 -1.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.7 -0.8 -0.8 0.0
Hearing difficulty/problems: Yes 0.5 0.7 1.0 0.9 1.0 -0.7
Relative age of first facial hair 1.3 2.6 7.2 0.3 -0.7 2.7
Other serious medical condition/disability diagnosed by doctor 3.2 4.1 9.2 -1.1 3.0 1.4
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 1.1 0.5 -0.2
Ever had hysterectomy (womb removed) 1.5 1.6 4.2 -0.5 -0.7 -2.0
Systolic blood pressure, automated reading 0.4 1.2 2.9 0.5 0.6 -1.7
Eye problems/disorders: Diabetes related eye disease 3.5 3.9 6.2 -2.5 1.8 -1.5
Angina 1.0 1.3 2.8 0.4 0.9 -1.7
Medication for hormone replacement therapy 1.5 1.7 3.5 1.9 -0.8 1.0
Vitamin and mineral supplements 0.6 0.8 2.0 1.4 -0.2 -0.4
Supplements: Zinc 0.7 0.8 1.2 -0.5 0.9 -1.1
Medication: Co-codamol 0.1 0.1 0.2 0.1 0.4 -0.4
Medication: Metformin 1.7 2.4 3.9 -1.6 2.0 -1.0
Diabetes (father) 0.3 0.3 0.6 -0.7 0.2 0.8
Diabetes (mother) 0.4 0.5 1.4 -0.2 0.2 -1.2
Severe depression (siblings) 1.9 2.2 3.5 -1.3 1.9 -1.1
Pack years adult smoking proportion 0.1 0.2 0.3 0.5 0.5 -0.3
Impedance of leg (right) 0.4 2.1 4.1 -2.0 1.2 -0.8
Leg fat-free mass (left) 0.2 0.8 1.5 -0.4 0.9 1.2
Trunk fat percentage 1.1 4.4 8.1 -2.1 2.8 -0.9
Hand grip strength (right) 0.3 0.8 0.9 0.9 1.0 0.8
Townsend deprivation index at recruitment 2.0 2.8 5.7 -1.2 2.4 -1.1
Current tobacco smoking 1.3 2.1 3.8 1.9 1.6 0.0
Average weekly fortified wine intake 0.4 0.5 1.4 -0.3 -0.1 1.2
Maternal smoking around birth 1.3 1.9 3.5 -1.9 1.4 0.5
Fed-up feelings 0.4 0.7 1.8 -0.1 1.4 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.1 1.8 -1.2 -0.1 1.4
Relative age voice broke 1.3 2.0 4.2 -0.9 -0.9 2.1
Taking other prescription medications 2.1 3.3 7.3 -1.6 2.7 -0.2
Age when periods started (menarche) 1.4 3.5 9.0 3.0 0.9 0.8
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.3 -0.4 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 0.8 0.9 0.9 -0.7
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 4.1 -2.0 0.7 1.4
Qualifications: CSEs or equivalent 0.6 0.8 1.5 -0.9 0.2 1.2
Serious illness, injury or assault to yourself 1.1 1.4 2.5 -1.6 1.2 0.5
High blood pressure 1.6 4.4 8.9 -1.6 3.0 1.3
Hayfever, allergic rhinitis or eczema 4.3 9.3 21.2 -0.6 2.5 4.6
Multivitamins +/- minerals 0.2 0.2 0.5 -0.7 0.0 -0.4
Stomach or abdominal pain in last month 0.5 0.6 1.8 -1.3 -0.1 0.2
Supplements: Glucosamine 1.5 1.9 5.7 -0.2 -0.1 2.4
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.3 -1.2 -0.7 1.0
Medication: Atenolol 0.5 0.6 1.1 0.2 0.7 -1.0
Medication: Levothyroxine sodium 0.2 0.3 0.7 -0.8 0.2 -0.5
Sitting height 0.5 3.7 9.0 1.0 1.1 3.0
Chronic bronchitis/emphysema (father) 0.5 0.6 1.0 1.0 0.8 -0.3
High blood pressure (mother) 1.0 1.3 2.7 -1.1 1.6 0.2
Body mass index (BMI) 0.2 0.7 1.1 -1.0 1.0 -0.3
Impedance of leg (left) 0.2 0.9 1.3 -1.2 1.1 -0.4
Leg predicted mass (left) 0.1 0.8 1.5 -0.3 0.9 1.2
Trunk fat mass 0.8 3.5 6.4 -2.0 2.5 -0.3
Waist circumference 0.8 2.9 4.5 -2.1 2.1 -0.1
Number of incorrect matches in round 0.4 0.7 2.1 0.1 -1.4 -0.1
Past tobacco smoking 1.3 2.4 6.0 2.5 -0.4 -1.0
Alcohol usually taken with meals 2.5 4.1 5.1 2.1 -1.6 2.2
Nervous feelings 0.6 1.2 1.8 -1.3 0.3 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 0.4 -0.2 0.3
Hearing difficulty/problems with background noise 0.6 0.9 1.6 1.0 1.3 -0.4
Hair/balding pattern: Pattern 2 1.2 1.5 1.7 -1.3 -1.2 1.1
Had menopause 1.0 1.2 3.1 -0.1 0.7 -1.8
Had other major operations 1.3 1.6 4.2 0.4 -0.5 -2.0
Forced vital capacity (FVC) 1.0 4.0 9.0 1.7 0.3 3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.9 0.1 1.0 0.1
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 -0.6 0.4 -0.2
Qualifications: None of the above 1.0 2.1 4.7 1.2 0.2 -2.2
Financial difficulties in last 2 years 1.1 1.4 2.3 -1.5 1.4 -0.2
Mouth/teeth dental problems 0.2 0.2 0.4 -0.5 0.2 0.6
Heart attack 0.2 0.2 0.3 -0.4 0.5 -0.3
Allergy 3.5 8.0 15.0 1.3 -2.7 -3.9
Pain all over the body in last month 2.5 2.7 4.2 -2.1 1.7 -1.0
Diabetes (self-reported) 2.9 4.6 10.4 -3.2 1.4 -1.1
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 4.7 -0.6 0.5 2.2
Medication: Ramipril 1.9 2.4 4.3 -1.7 2.1 -0.2
Medication: Simvastatin 2.9 4.2 8.8 -3.0 1.3 -1.5
Fluid intelligence score 0.2 0.3 0.5 0.5 0.7 0.5
Illnesses of siblings 0.4 0.6 1.6 -0.1 -0.5 -1.3
Neuroticism score 0.7 1.5 2.5 -1.4 1.6 -0.2
Weight 0.3 1.4 2.4 -1.2 1.6 0.6
Impedance of arm (right) 0.6 2.8 7.7 -0.4 2.8 -0.7
Arm fat percentage (right) 0.8 3.2 6.7 -1.6 2.6 -0.4
Trunk fat-free mass 0.2 1.2 3.3 -0.0 -0.4 1.8
Hip circumference 0.3 1.3 2.6 -0.7 1.6 -0.9
Time employed in main current job 0.1 0.1 0.2 0.4 -0.3 0.4
Alcohol intake versus 10 years previously 0.3 0.5 0.9 -0.2 0.7 0.9
Father’s age at death 0.7 0.9 1.6 -0.8 -0.7 1.3
Worrier / anxious feelings 0.4 0.8 1.6 -0.7 0.5 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 0.9 -0.8 -0.9 0.9
Falls in the last year 0.6 0.9 1.7 0.8 1.3 0.4
Hair/balding pattern: Pattern 3 2.2 3.2 7.1 1.6 0.3 -2.7
Number of live births 0.6 0.8 2.4 0.2 -1.5 -0.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 3.8 0.9 0.2 2.0
Pulse rate 1.8 3.0 7.1 0.3 2.7 1.4
Happiness 0.4 0.5 1.2 -0.2 -1.1 -0.4
Noisy workplace 0.7 0.8 1.5 -0.8 1.2 -0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.4 0.1 -0.1 1.6
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 2.9 -1.6 1.7 -0.2
Mouth/teeth dental problems: Dentures 2.4 4.0 11.3 3.4 -0.6 -0.6
Asthma 2.2 4.3 4.7 -2.1 2.2 1.9
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 6.0 -0.3 0.2 2.4
Medication: Cholesterol lowering 1.1 1.7 2.5 -1.4 1.6 -0.7
Depression (self-reported) 1.7 2.0 3.3 1.8 1.6 -0.6
Medication: Lansoprazole 1.9 2.1 3.5 -0.3 -1.9 1.7
Prospective memory result 3.8 4.7 11.7 1.2 -1.0 -3.4
Lung cancer (father) 1.6 1.9 2.6 0.8 1.6 -1.6
Illnesses of mother 0.6 0.7 1.6 0.3 -1.3 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.1 0.8 -0.0 1.4
Pulse wave Arterial Stiffness index 1.4 1.7 3.1 0.1 -1.8 1.4
Impedance of arm (left) 0.7 3.2 7.3 -0.9 2.7 -1.2
Arm fat mass (right) 0.5 2.1 4.5 -1.3 2.1 -0.1
Trunk predicted mass 0.2 1.3 3.6 -0.0 -0.4 1.9
Standing height 0.2 1.9 3.2 -0.3 1.5 1.8
Length of working week for main job 0.6 0.7 1.8 -1.4 -0.1 0.4
Exposure to tobacco smoke at home 1.1 1.3 1.9 -1.4 1.2 -0.6
Breastfed as a baby 0.9 1.1 2.1 0.8 -0.7 -1.4
Tense / ‘highly strung’ 0.5 0.8 1.9 -1.4 0.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 3.4 -1.2 1.9 0.7
Hair/balding pattern: Pattern 4 1.2 3.0 4.0 2.0 1.1 -2.0
Birth weight of first child 1.2 2.2 4.8 -1.2 0.4 2.2
Peak expiratory flow (PEF) 0.3 0.8 1.7 -0.4 0.7 1.3
Pulse wave reflection index 1.5 1.8 4.0 -2.0 -0.9 0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.6 0.4 0.1 -0.8
Loud music exposure frequency 0.7 0.8 1.4 -0.9 -1.2 0.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.4 -0.8 0.2 1.2
Mouth/teeth dental problems: Bleeding gums 1.5 1.9 3.7 -1.9 -0.7 1.2
Blood clot in the leg (DVT) 0.9 1.2 2.8 -0.8 1.7 -0.1
Medication: Paracetamol 2.0 3.4 6.1 -2.5 0.2 2.0
Headache pain in last month 0.6 1.1 3.2 0.2 -0.2 1.8
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 4.1 2.0 -1.3 -1.2
Glaucoma (self-reported) 2.1 2.4 6.9 -2.6 0.2 0.6
Gout (self-reported) 2.4 3.2 4.9 -2.2 0.8 2.0
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 1.6 -1.2 1.3 -0.1
Medication: Amlodipine 0.4 0.5 1.5 -0.3 1.2 0.1
Medication: Ventolin 100micrograms inhaler 1.8 2.3 4.3 -1.1 2.1 1.1
Birth weight 0.5 1.2 3.4 0.2 0.2 1.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.3 -0.0 -0.5
High blood pressure (siblings) 0.6 0.9 2.6 -0.2 0.3 1.6
Forced vital capacity (FVC), Best measure 0.6 2.2 5.3 1.0 0.4 2.3
Body fat percentage 1.0 4.1 6.8 -2.2 2.6 -0.8
Leg fat percentage (right) 1.3 4.5 8.3 -2.9 2.1 -1.0
Arm fat-free mass (right) 0.2 0.9 1.9 -0.8 -0.5 1.4
Exposure to tobacco smoke outside home 0.7 0.9 1.8 -1.3 0.7 -0.6
Comparative body size at age 10 0.7 1.8 5.0 -0.2 0.7 -2.2
Number of full brothers 3.7 4.6 8.5 -1.9 2.9 -1.3
Worry too long after embarrassment 1.0 1.6 2.7 -1.6 1.4 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 8.0 -0.2 2.8 0.5
Wheeze or whistling in the chest in last year 0.7 1.2 2.7 -0.9 1.6 -0.2
Number of children fathered 1.0 1.2 2.3 -0.9 0.6 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.3 -0.4 0.4 0.6
Age at first live birth 0.8 1.4 2.6 -0.6 1.6 1.2
Pulse wave peak to peak time 1.8 2.1 4.1 -0.2 2.0 -1.5
Health satisfaction 0.5 0.7 1.5 0.5 -0.5 1.2
Shortness of breath walking on level ground 0.8 1.0 2.2 -1.5 -0.2 0.8
Qualifications: College or University degree 0.9 2.8 7.5 0.7 0.6 2.7
Eye problems/disorders: None of the above 0.0 0.0 0.0 -0.0 -0.0 -0.2
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.2 -1.1 0.3 0.4
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.1 -0.4 -0.3
Medication for pain relief, constipation, heartburn 2.0 3.5 5.3 2.3 -2.3 -0.2
Neck or shoulder pain in last month 1.9 2.8 5.1 0.9 -1.6 2.3
Medication: Blood pressure 1.6 2.9 4.2 -1.6 1.4 2.1
Angina (self-reported) 1.1 1.5 3.4 0.2 1.0 -1.8
Migraine (self-reported) 1.2 1.5 4.3 -0.5 -2.1 0.2
Medication: Ibuprofen 1.5 1.8 5.1 -0.0 0.4 2.2
Medication: Allopurinol 2.7 3.6 5.5 -2.4 1.3 1.9
Medication: Omeprazole 3.1 3.7 7.0 -1.4 2.6 -1.4
Medication: Seretide 50 evohaler 1.3 1.5 2.3 -1.5 -0.0 1.4
Mean time to correctly identify matches 0.0 0.0 0.1 -0.1 -0.3 0.1
Heart disease (mother) 0.8 1.0 1.5 -1.2 0.8 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.5 0.7 0.1 0.1
Whole body fat mass 0.7 2.7 4.9 -1.8 2.2 -0.0
Leg fat mass (right) 0.8 3.2 5.2 -2.3 2.1 -0.1
Arm predicted mass (right) 0.2 0.8 1.9 -0.4 -0.7 1.4
Pulse rate, automated reading 0.9 3.0 8.1 -0.9 2.8 0.4
Alcohol intake frequency. 0.4 0.9 1.6 -0.4 -0.9 -1.3
Comparative height size at age 10 0.5 2.9 4.4 -1.9 2.1 -0.9
Number of full sisters 0.2 0.3 0.3 0.5 0.5 -0.5
Suffer from ‘nerves’ 0.2 0.2 0.5 -0.5 0.7 -0.0
Overall health rating 1.1 2.3 3.3 -1.1 1.8 -1.5
Chest pain or discomfort 2.1 3.0 5.2 -2.3 1.9 -0.4
Had major operations 0.9 1.0 2.9 -1.7 -0.3 0.4
Age at last live birth 1.6 2.4 4.2 -1.7 -0.0 2.1
Family relationship satisfaction 0.6 0.8 1.5 -0.5 0.7 1.2
Leg pain on walking 0.0 0.0 0.1 -0.3 -0.0 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.3 -0.7 -1.1 0.1
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.0 -1.7 1.2 -0.8
Illness, injury, bereavement, stress in last 2 years 4.8 5.9 14.3 3.8 -1.8 0.1
Medication: Aspirin 5.0 6.6 11.1 -3.3 1.9 -2.3
Supplements: Vitamin C 1.3 1.6 2.6 -1.6 1.4 0.4
Knee pain experienced in last month 0.8 1.3 2.2 1.0 0.8 1.5
Hypertension (Self-reported) 1.2 3.3 6.8 -1.2 2.6 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 2.4 -1.2 -1.3 1.5
Illnesses of father: Heart disease 0.6 0.8 1.5 1.0 1.2 -0.0
Illnesses of siblings: Diabetes 2.9 3.5 9.4 0.5 3.1 -0.9
Smoking status: Previous 1.6 2.4 6.7 -2.6 0.3 0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 6.5 -2.0 1.3 2.5
Whole body fat-free mass 0.1 0.8 2.4 -0.1 -0.0 1.6
Leg fat-free mass (right) 0.2 1.0 2.4 0.3 0.8 1.5
Arm fat percentage (left) 0.8 3.3 6.2 -1.8 2.5 -0.6
Average weekly red wine intake 1.6 2.4 6.9 2.6 0.2 0.5
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.6 0.6 1.3 -0.4
Mood swings 0.4 0.7 1.6 0.6 0.4 -1.3
Loneliness, isolation 0.3 0.5 1.1 0.0 1.1 -0.5
Long-standing illness, disability or infirmity 2.7 4.2 8.3 -1.7 2.9 1.2
Ever had bowel cancer screening 0.5 0.6 1.4 -0.5 0.3 -1.2
Diabetes diagnosed by doctor 2.0 3.2 6.0 -2.5 1.2 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.7 4.1 -1.4 2.0 1.5
Friendships satisfaction 0.9 1.1 2.8 -0.6 -0.3 1.7
Qualifications: nursing, teaching 0.5 0.7 2.1 0.3 -0.1 1.5
Commuting to job workplace: Walk 1.4 1.5 2.0 -1.4 1.2 -1.0
Eye problems/disorders: Cataract 0.8 0.9 2.2 1.5 -0.6 0.4
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 -0.1 -0.0 -0.3
Medication for cholesterol 0.3 0.5 0.8 -0.9 -0.6 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 3.0 1.1 1.7 -0.8
Back pain experienced in last month 0.5 0.7 1.4 1.2 -0.1 0.8
Mineral and other dietary supplements 0.9 1.2 2.6 1.6 -0.6 -0.8
Breast cancer (self-reported) 0.7 0.8 1.2 -0.5 1.1 -1.0
Asthma (self-reported) 2.0 4.0 4.6 -1.8 2.0 2.1
Osteoporosis (self-reported) 0.5 0.7 1.8 0.4 -0.3 1.3
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.0 -0.6 0.8
Medication: Aspirin 4.7 6.1 9.0 -2.5 1.8 -3.0
Medication: Gliclazide 1.2 1.3 3.2 -0.6 0.6 -1.8
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 -0.6 -0.9 -0.6
Smoking status: Current 1.1 1.8 3.6 1.9 1.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 0.7 -1.4 -0.3
Whole body water mass 0.1 0.8 2.5 -0.1 -0.1 1.6
Leg predicted mass (right) 0.2 1.0 2.5 0.3 0.7 1.6
Arm fat mass (left) 0.5 2.1 3.9 -1.5 2.0 -0.1
Number of self-reported non-cancer illnesses 1.3 2.3 2.8 -1.3 1.5 1.7
Average weekly champagne plus white wine intake 0.4 0.6 0.7 0.9 -0.4 0.9
Miserableness 0.5 0.9 2.1 -0.6 1.4 -0.4
Guilty feelings 2.3 3.5 8.1 -2.8 1.0 1.2
Wears glasses or contact lenses 0.8 0.9 2.4 -0.1 -0.6 1.6
Ever taken oral contraceptive pill 0.7 0.7 2.0 -0.4 1.4 0.2
Hearing aid user 1.2 1.4 4.1 0.1 -0.1 2.0
Mother’s age at death 0.1 0.1 0.2 0.2 -0.5 0.0
Financial situation satisfaction 1.3 1.6 3.4 -1.8 0.2 1.2
Tinnitus: Yes, now most or all of the time 0.7 0.9 1.8 0.9 0.1 -1.4
Commuting to job workplace: Public transport 1.1 1.3 3.1 1.8 0.1 0.9
Eye problems/disorders: Glaucoma 1.7 2.0 5.1 -2.3 0.6 0.8
Medication: Blood pressure 1.2 2.3 3.7 0.3 1.9 -1.7
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.6 -0.5 0.5 -0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.8 -1.3 0.5 0.7
High cholesterol (Self-reported) 0.3 0.5 1.6 -1.3 0.0 0.0
Medication: Bendroflumethiazide 0.8 1.1 1.9 -0.7 1.4 1.0
Medication: Paracetamol 1.4 2.2 4.6 -2.1 0.3 1.4
Medication: Lisinopril 1.6 2.1 3.9 2.0 1.4 -0.6
Medication: Atorvastatin 0.5 0.6 1.2 0.5 1.1 -0.6
Illnesses of father: High blood pressure 0.9 1.1 2.6 -1.6 0.3 0.7
Alcohol drinker status: Never 1.8 2.2 4.5 0.4 -2.1 -1.4
Ever smoked 0.4 0.7 1.8 -1.4 0.3 0.5
Basal metabolic rate 0.2 0.9 2.2 -0.5 0.5 1.5
Leg fat percentage (left) 0.8 3.0 4.7 -2.2 2.0 -0.6
Arm fat-free mass (left) 0.1 0.7 1.6 -0.5 -0.3 1.3
Number of operations (self-reported) 0.5 0.8 1.5 0.1 -1.2 -0.9
Average weekly beer plus cider intake 0.6 0.9 1.3 -1.2 1.1 -0.5
Irritability 0.3 0.5 1.0 -1.0 -0.5 -0.6
Risk taking 0.4 0.6 1.2 1.1 0.7 -0.1
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.4 -0.8 1.2 1.0
Fractured/broken bones in last 5 years 1.3 1.7 2.2 -1.5 1.4 0.9
Age started oral contraceptive pill 0.9 1.1 2.5 0.6 -1.6 -0.7
Diastolic blood pressure, automated reading 0.3 0.9 1.8 -0.9 1.3 0.4
Ever depressed for a whole week 2.6 3.2 5.0 -1.9 2.2 -0.9
Unable to work because of sickness or disability 3.4 4.3 9.4 -1.9 3.1 -0.2
Commuting to job workplace: Cycle 1.3 1.5 2.5 -0.7 1.6 1.3
Myopia 0.7 1.0 1.3 1.1 -1.0 -0.8
Vascular/heart problems diagnosed by doctor 1.9 5.0 11.2 2.0 -3.4 -0.2
Cholesterol lowering medication 0.7 1.0 2.2 -1.5 0.6 -0.5
Medication: Omeprazole (e.g. Zanprol) 2.6 3.2 8.0 -0.5 2.8 -1.2
Pain experienced in last month 1.3 2.2 4.0 -1.2 1.1 -2.0
Supplements: Calcium 0.6 0.7 1.3 1.1 0.8 -0.4
Basal cell carcinoma (self-reported) 0.9 1.0 3.1 -0.1 1.8 -0.0
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 -0.7 0.6 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.4 -0.9 1.5 0.0
Heart disease (siblings) 0.3 0.4 1.1 -1.0 0.0 -0.4
Alcohol drinker status: Previous 1.6 1.8 3.3 0.9 1.8 1.1
Pack years of smoking 0.2 0.3 0.4 0.6 0.2 -0.6
Impedance of whole body 0.3 1.7 3.5 -0.9 1.9 -0.9
Leg fat mass (left) 0.6 2.4 3.9 -1.8 2.0 0.1
Arm predicted mass (left) 0.1 0.6 1.6 -0.4 -0.1 1.2