Hub : Genes

TUSC3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0240	4.6e-03	0.031	0.020	0.026	0.029	0.034	8.9e-05	1.6e-03	3.2e-04	1.7e-04	4.9e-05
2	GTEx	Brain Cerebellum	0.3180	0.0990	4.4e-03	0.119	NA	0.127	NA	0.181	2.3e-04	NA	1.4e-04	NA	4.9e-06
3	GTEx	Ovary	0.7450	0.0940	6.9e-06	0.308	NA	0.263	NA	0.384	2.6e-08	NA	3.7e-07	NA	2.0e-10
4	ROSMAP	Brain Pre-frontal Cortex	0.0808	0.0240	4.8e-05	0.047	0.049	0.065	0.055	0.074	9.3e-07	5.9e-07	9.1e-09	1.3e-07	9.7e-10
5	TCGA	Breast Invasive Carcinoma	0.0693	0.0203	0.0e+00	0.126	0.094	0.108	NA	0.120	7.9e-25	1.4e-18	3.3e-21	NA	1.3e-23
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0452	0.0238	5.6e-03	0.013	0.018	0.017	NA	0.013	1.2e-02	3.3e-03	4.0e-03	NA	1.0e-02
7	TCGA	Brain Lower Grade Glioma	0.0414	0.0190	1.6e-03	0.015	0.022	0.011	NA	0.013	7.0e-03	1.5e-03	1.9e-02	NA	1.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.9	3.1	6.7	2.6	0.6	-1.4	2.0	1.5	0.4	2.6
Bipolar Disorder or Schizophrenia	1.0	2.4	7.2	0.9	-0.9	-1.1	1.7	1.9	0.6	2.7
Depressed Affect (Nagel 2018)	1.6	3.4	8.0	-2.0	0.3	1.7	-2.8	-2.2	-0.1	-2.0
Depression (Nagel 2018)	0.1	0.2	0.4	0.1	0.5	-0.4	-0.6	-0.1	0.4	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.9	0.2	1.1	-0.8	-1.1	-2.0	0.3	-0.7
Neuroticism (Nagel 2018)	1.7	3.9	8.1	-2.3	-1.0	2.0	-2.9	-2.2	0.7	-2.0
Schizophrenia (2018)	0.5	1.1	2.4	-0.9	-1.5	-0.4	0.9	1.2	0.5	1.4
Schizophrenia vs Biploar Disorder	1.2	1.6	3.5	-1.9	-0.4	1.4	-1.3	-1.5	0.8	-0.9
Worry (Nagel 2018)	0.9	1.8	4.6	-1.6	-2.2	1.1	-1.5	-1.0	0.6	-0.8
Alzheimer’s Disease (in mother)	0.8	0.9	2.4	-1.2	0.4	1.5	-0.4	-0.4	1.2	-1.0
Alzheimer’s Disease (in father)	1.4	1.6	4.1	1.3	1.9	-2.0	0.7	0.8	-0.4	0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	2.0	0.0	1.4	-0.1	0.4	0.6	0.7	-0.1
Crohns Disease (2017)	0.0	0.1	0.4	-0.2	0.2	0.4	0.1	-0.3	0.6	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.1	0.4	-0.3	0.6	0.5	0.7	0.3
Ulcerative Colitis (UC)	0.3	0.6	1.1	0.7	0.4	-1.1	0.9	0.8	0.1	0.9
Major Depression (MDD)	1.0	1.2	4.3	0.2	-2.1	0.1	1.1	1.2	0.3	1.1
Reaction Time	0.5	0.9	3.0	0.6	-1.7	-1.1	-1.1	0.1	-0.8	-0.3
Verbal and Numeric Reasoning (VNR)	0.9	2.3	7.3	1.7	2.7	-1.4	-0.7	-1.9	0.3	0.0
Breast Cancer	0.3	0.7	3.1	-0.1	-0.0	1.8	-0.4	-0.1	0.8	-1.0
Ovarian Cancer	1.0	1.3	4.5	2.1	1.3	-0.7	1.1	0.3	-0.9	0.5
Prostate Cancer	0.2	0.2	0.6	-0.1	-0.3	0.6	0.8	0.7	-0.0	-0.4
Age at First Birth	1.3	1.8	3.6	1.5	0.7	-1.9	1.9	1.0	-0.9	1.0
Bipolar Disorder (2011)	1.3	1.3	3.2	0.9	-0.9	-0.6	0.8	1.1	-1.3	1.8
Body Mass Index (BMI) (2010)	0.5	0.7	2.8	-0.9	-0.8	-0.2	-0.5	0.4	-1.7	-0.3
Coronary Artery Disease (CAD)	0.3	0.4	1.5	-1.2	-0.1	-0.8	-0.1	-0.3	-0.7	-0.2
Crohns Disease (2012)	0.9	1.5	3.3	-1.4	-0.8	1.6	0.8	1.3	1.8	0.0
Mean Putamen Volume	0.2	0.3	1.0	0.5	0.6	-0.0	-0.1	-0.4	-1.0	0.2
Fasting Glucose	1.0	1.1	4.0	-0.2	-1.4	-0.2	-1.1	-0.6	-2.0	-0.6
HbA1C	0.2	0.2	0.6	0.1	0.8	-0.4	-0.4	-0.5	-0.5	0.0
HDL Cholesterol	0.3	0.6	2.2	-1.5	-0.3	-0.2	-0.2	0.4	0.9	-0.8
LDL Cholesterol	0.4	0.7	1.4	0.5	0.9	0.5	-0.2	-1.2	-1.2	-0.6
Lupus	1.3	2.0	3.4	-1.8	-0.9	1.6	-1.6	-1.3	-0.7	-1.5
Neuroticism (2016)	0.4	0.5	1.8	-0.1	-1.3	0.0	0.2	0.4	1.2	0.2
Primary Biliary Cirrhosis	1.4	1.9	5.5	0.2	-1.3	0.6	1.8	1.4	2.4	0.9
Rheumatoid Arthritis	0.2	0.3	1.1	0.5	-0.2	-0.8	0.4	-0.4	-1.0	-0.2
Schizophrenia (2014)	0.4	0.8	1.8	-0.9	-1.2	0.2	0.3	0.6	1.3	1.1
Triglycerides	0.3	0.5	1.2	1.1	0.7	0.4	0.6	0.2	0.1	1.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.1	-0.3	0.5	-0.5	-0.7	0.2	-0.0
Ulcerative Colitis	0.7	1.0	2.1	0.1	-0.0	-0.4	1.4	1.5	1.1	1.3
Blood Eosinophil Count	0.2	1.6	4.7	-2.2	-1.3	0.3	-1.4	-1.0	-0.1	-1.4
Blood Platelet Count	0.1	0.7	2.2	1.0	-0.8	-0.9	0.5	0.1	0.4	1.5
Blood Red Count	0.1	0.8	3.9	0.1	-0.7	-2.0	0.4	0.7	-0.2	0.7
Blood White Count	0.2	1.3	4.7	0.3	0.3	-0.1	1.4	1.1	2.2	0.8
Heel T-Score	0.3	2.2	6.7	0.6	-1.3	-0.9	-1.5	-1.9	-2.6	-0.1
BMI	2.4	13.9	33.6	-4.4	-2.1	0.9	-5.8	-3.6	-2.9	-4.1
Height	0.0	0.6	1.3	1.0	1.1	0.5	0.4	-0.2	1.2	0.3
Waist Hip Ratio (WHR)	0.2	1.1	3.2	0.0	0.5	-0.3	-1.8	-1.5	-1.1	-0.7
Systolic Blood Pressure	0.4	1.8	4.0	-0.0	-1.3	-1.1	1.6	2.0	1.1	1.2
Smoking Status	0.9	2.2	6.2	-1.0	0.5	0.3	-2.5	-1.7	-2.3	-0.5
Allergy or Eczema	0.6	1.6	3.1	0.6	0.8	-0.9	1.5	1.2	1.8	1.4
Cardiovascular Disease	0.5	1.7	6.2	-1.2	-0.9	-1.6	-1.0	-0.1	-2.5	-0.2
Hypothyroidism (self reported)	0.1	0.2	0.8	0.1	0.4	-0.5	0.0	-0.1	-0.9	-0.2
Respiratory disease	0.5	1.2	4.8	-0.6	0.3	0.8	1.0	1.2	2.2	0.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.9	0.9	-0.3	-1.0	0.5	-0.1	-1.4	1.3
Lung FEV1/FVC ratio	0.5	2.6	5.5	1.9	-0.5	-1.2	1.8	2.0	-0.7	2.3
Lung FVC	0.1	0.4	1.2	-1.1	-0.4	0.5	-0.6	0.2	-1.0	0.0
Neuroticism	1.2	2.8	6.5	-1.7	-0.7	2.6	-1.9	-1.4	1.0	-1.7
Chronotype (morning person)	0.9	2.0	6.4	0.2	0.4	-1.7	-1.3	-1.6	-2.5	-0.6
Hair Pigment	0.0	1.3	3.6	-0.4	-0.6	1.0	1.0	1.9	1.7	0.0
Tanning	0.1	1.1	2.7	1.4	1.1	-0.3	1.6	0.9	0.1	0.9
Hand grip strength (left)	0.6	1.7	8.7	-0.8	-3.0	-0.2	0.0	1.1	0.2	1.1
Number of treatments/medications taken	0.4	0.7	2.6	-0.8	-1.6	0.6	0.3	0.7	0.5	0.8
Average weekly spirits intake	2.7	3.3	10.9	-3.3	-0.8	1.7	-1.9	-0.6	0.6	-2.0
Sensitivity / hurt feelings	1.0	1.8	6.6	-0.6	-1.1	2.6	-0.1	0.3	2.0	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.8	0.1	1.3	-0.3	-0.7	-0.1	0.5	-0.1
Hearing difficulty/problems: Yes	0.4	0.7	1.4	-0.3	0.2	1.1	-1.2	-1.1	0.8	0.3
Relative age of first facial hair	1.3	2.6	7.0	-0.9	0.1	2.6	-0.7	-1.6	2.4	-1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.7	-0.4	1.3	1.3	-0.4	-0.3	-0.5	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.6	-1.4	-0.6	1.6	0.2	0.1	0.2	-0.8
Ever had hysterectomy (womb removed)	0.8	0.9	2.3	-1.5	-1.1	1.3	-0.4	-0.2	-0.3	-0.9
Systolic blood pressure, automated reading	0.3	0.8	2.5	-1.4	-1.6	0.5	-0.4	0.2	0.7	-0.4
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	5.1	-1.6	0.1	1.0	-2.3	-1.9	0.2	-2.0
Angina	0.8	1.0	4.2	-0.1	-2.1	0.5	0.6	1.2	0.2	1.0
Medication for hormone replacement therapy	0.9	1.0	3.3	0.8	-1.8	0.6	0.6	0.1	-0.3	1.4
Vitamin and mineral supplements	0.7	0.9	3.3	0.0	1.8	-1.3	0.2	0.7	0.9	-0.2
Supplements: Zinc	0.8	0.9	2.5	1.1	1.6	0.0	1.1	0.6	0.2	0.7
Medication: Co-codamol	0.2	0.3	0.5	-0.7	0.4	0.6	-0.0	-0.3	-0.5	-0.7
Medication: Metformin	1.3	1.8	5.6	0.3	1.1	-0.5	-1.2	-2.1	-2.4	-0.0
Diabetes (father)	0.3	0.3	1.5	0.2	1.2	-0.7	0.1	0.3	0.6	-0.2
Diabetes (mother)	0.6	0.8	1.6	-1.3	-1.1	-0.6	-1.2	-0.2	-0.3	-0.6
Severe depression (siblings)	0.2	0.3	0.6	-0.5	-0.7	-0.1	-0.5	0.5	0.2	0.7
Pack years adult smoking proportion	0.2	0.4	0.8	-0.8	0.2	0.7	-0.4	-0.5	0.3	-0.9
Impedance of leg (right)	0.7	3.5	9.4	0.6	-2.0	0.1	3.1	2.5	1.2	1.8
Leg fat-free mass (left)	0.9	4.6	11.8	-1.5	1.4	0.2	-3.4	-2.7	-1.8	-2.3
Trunk fat percentage	0.5	2.1	4.7	-1.9	-0.1	1.3	-2.2	-1.4	-0.5	-1.4
Hand grip strength (right)	0.6	1.5	6.1	-1.2	-2.5	-0.3	0.3	1.4	0.7	0.7
Townsend deprivation index at recruitment	0.8	1.2	2.4	0.4	-0.9	-1.2	0.5	1.6	-1.1	1.4
Current tobacco smoking	1.8	3.0	8.5	-1.4	0.5	0.0	-2.5	-1.6	-2.9	-1.3
Average weekly fortified wine intake	1.2	1.4	5.4	-0.5	0.6	2.3	-0.1	-0.7	0.7	-1.7
Maternal smoking around birth	2.2	3.2	6.2	2.4	-0.0	-1.8	1.7	1.4	-1.2	2.5
Fed-up feelings	2.0	3.6	7.7	-2.1	0.5	1.8	-2.8	-2.1	0.1	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.1	-1.5	0.6	0.4	-1.4	-0.5	-0.2	-1.0
Relative age voice broke	1.2	1.9	4.1	-1.0	-0.6	2.0	-1.4	-2.0	-0.5	-1.3
Taking other prescription medications	0.2	0.4	1.1	-0.7	-0.8	1.1	-0.0	-0.4	-0.3	0.4
Age when periods started (menarche)	1.5	3.6	10.8	-2.6	-0.4	3.3	0.3	1.2	2.0	-1.1
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	3.8	-2.0	-1.8	1.6	-0.6	0.4	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.5	0.8	-0.7	-1.2	-0.6	-0.6	-0.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.0	-0.9	-0.6	0.4	-0.8	-0.9	0.5	-1.0
Qualifications: CSEs or equivalent	1.9	2.5	9.2	-0.2	-0.8	-3.0	-0.6	1.0	-2.4	0.5
Serious illness, injury or assault to yourself	2.1	2.5	6.0	-2.5	-1.3	2.1	-1.4	-0.2	0.0	-1.9
High blood pressure	1.1	3.0	5.5	-2.1	-1.4	0.5	-2.3	-1.4	-2.3	-1.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.6	0.9	1.0	-0.7	1.9	1.4	1.7	1.7
Multivitamins +/- minerals	1.1	1.5	4.4	-0.7	-2.0	0.5	-0.6	-0.8	-2.1	0.0
Stomach or abdominal pain in last month	0.9	1.1	2.6	-1.0	-0.3	1.4	-0.9	-0.6	0.8	-1.6
Supplements: Glucosamine	0.7	0.9	1.8	1.3	0.0	0.8	1.3	0.5	0.3	1.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.8	-1.0	-1.1	1.6	1.0	0.9	2.4	-0.1
Medication: Atenolol	0.8	1.0	3.2	-1.2	-1.8	0.4	-0.2	0.2	0.4	-1.2
Medication: Levothyroxine sodium	1.1	1.9	3.8	1.4	1.3	-1.4	1.5	1.1	-0.9	1.9
Sitting height	0.1	0.4	1.1	0.0	1.1	-0.7	0.3	-0.6	0.8	-0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-1.1	-0.5	-1.0	0.4	1.4	-0.6	0.4
High blood pressure (mother)	0.3	0.5	2.7	-0.2	-1.6	-0.1	-0.1	0.1	-0.2	0.7
Body mass index (BMI)	1.3	5.5	15.4	-2.5	0.0	0.4	-3.9	-2.3	-2.1	-2.6
Impedance of leg (left)	0.6	3.1	7.9	0.9	-1.8	-0.0	2.8	2.2	1.0	1.9
Leg predicted mass (left)	0.9	4.5	11.6	-1.5	1.4	0.2	-3.4	-2.7	-1.8	-2.3
Trunk fat mass	0.8	3.3	8.2	-2.2	0.1	1.3	-2.9	-1.9	-1.0	-2.0
Waist circumference	1.7	6.1	16.0	-2.4	0.8	0.9	-4.0	-2.9	-1.5	-2.9
Number of incorrect matches in round	1.6	2.7	8.3	1.2	-0.5	-0.5	2.2	2.9	1.2	1.6
Past tobacco smoking	0.5	1.0	1.7	-0.3	-1.0	-1.0	-0.9	-1.3	-1.2	-0.8
Alcohol usually taken with meals	1.7	2.7	8.2	0.4	-0.1	1.3	2.5	1.7	2.9	0.1
Nervous feelings	0.4	0.7	4.7	0.0	-0.5	0.3	0.1	-0.2	2.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.2	0.3	1.3	-0.7	-1.1	0.9	-0.7
Hearing difficulty/problems with background noise	0.2	0.4	1.2	0.8	0.1	0.8	0.1	-0.0	0.4	1.1
Hair/balding pattern: Pattern 2	1.5	1.9	5.0	-1.5	-0.8	2.1	-0.8	-0.5	2.2	-0.5
Had menopause	1.5	1.9	8.8	-0.3	-0.2	3.0	1.1	1.0	1.5	-0.2
Had other major operations	0.5	0.7	2.4	-0.6	-0.3	1.6	0.4	0.4	1.2	0.2
Forced vital capacity (FVC)	0.1	0.2	0.5	-0.3	-0.6	-0.2	0.3	0.6	0.1	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.8	0.5	-0.1	-1.7	-1.1	-1.3	-1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.5	0.3	-0.8	-1.0	0.3	0.4	-1.6	0.4
Qualifications: None of the above	0.4	0.8	3.5	-0.8	0.6	1.9	0.3	0.7	0.4	-0.1
Financial difficulties in last 2 years	1.1	1.5	4.9	-1.4	-0.6	2.2	-1.1	-0.6	-0.0	-1.4
Mouth/teeth dental problems	1.0	1.5	2.8	-1.7	-1.3	1.2	-0.6	-1.3	0.1	-1.6
Heart attack	0.5	0.7	2.7	-0.4	-1.6	0.8	0.4	1.0	0.2	0.2
Allergy	1.1	2.4	8.5	-0.1	-1.4	-0.6	-1.8	-1.5	-2.9	-0.9
Pain all over the body in last month	0.6	0.7	1.9	-1.3	0.2	0.1	-0.4	0.2	-1.4	-0.8
Diabetes (self-reported)	0.5	0.8	2.6	0.7	0.4	-0.9	-0.1	-0.7	-1.6	0.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.8	1.4	-0.3	-1.4	1.6	1.6	1.0	2.2
Medication: Ramipril	1.0	1.2	2.8	-0.4	-1.1	-1.4	0.5	1.2	-1.7	0.9
Medication: Simvastatin	0.6	0.9	1.9	0.4	-1.1	-0.8	0.9	1.0	-0.5	1.4
Fluid intelligence score	1.0	2.1	7.2	-0.3	1.4	0.1	-1.8	-2.7	0.0	-1.4
Illnesses of siblings	2.5	3.5	8.0	2.8	2.8	-2.1	0.4	-0.8	-1.7	0.8
Neuroticism score	1.2	2.5	5.1	-1.5	-0.4	2.2	-2.1	-1.4	0.6	-1.7
Weight	1.0	4.8	12.4	-2.2	0.5	0.8	-3.5	-2.5	-1.5	-2.7
Impedance of arm (right)	1.2	5.8	15.7	1.6	-0.2	1.1	4.0	2.5	2.8	2.6
Arm fat percentage (right)	0.6	2.3	6.3	-1.9	0.5	0.8	-2.5	-1.5	-0.9	-1.6
Trunk fat-free mass	0.6	3.2	7.8	-0.9	1.2	-0.0	-2.8	-2.1	-1.8	-2.3
Hip circumference	0.6	2.5	5.7	-1.8	0.9	0.9	-2.4	-1.8	-0.4	-2.0
Time employed in main current job	0.3	0.3	1.6	0.5	1.3	-0.6	0.0	-0.2	-0.4	0.1
Alcohol intake versus 10 years previously	0.5	0.8	2.5	-0.7	-1.3	-1.6	0.2	1.0	0.1	0.3
Father’s age at death	1.7	2.3	6.2	2.5	2.0	-1.7	0.6	-0.3	-1.0	1.1
Worrier / anxious feelings	1.3	2.5	4.8	-1.6	-2.2	1.8	-1.7	-0.9	1.7	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	2.0	-0.0	-0.2	-1.4	-0.8	0.7	-0.9	0.2
Falls in the last year	0.8	1.0	6.0	0.8	2.5	0.4	0.6	-0.2	0.1	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.3	1.1	0.2	0.2	0.2	-0.6	-1.1	0.7
Number of live births	0.8	1.2	5.3	-0.7	1.0	0.9	0.0	0.5	2.3	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.8	-0.2	-0.6	0.1	0.3	0.6	0.9	0.5
Pulse rate	0.2	0.3	0.9	-0.8	0.3	-0.9	-0.0	0.2	0.3	0.4
Happiness	0.9	1.1	2.6	-1.6	0.7	0.6	-1.1	-1.0	-0.3	-1.4
Noisy workplace	0.9	1.2	3.2	0.7	-0.6	-0.6	1.2	1.8	0.5	1.4
Qualifications: A levels/AS levels or equivalent	1.1	2.5	8.4	2.9	-0.1	-1.5	1.6	-0.7	-0.7	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.0	-2.0	-0.5	1.1	-1.4	0.1	0.2	-1.6
Mouth/teeth dental problems: Dentures	0.3	0.6	1.6	0.0	1.1	1.3	0.2	0.6	0.8	0.4
Asthma	0.7	1.4	5.0	-0.7	1.3	0.7	0.8	1.0	2.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.9	-0.7	0.7	-0.7	-0.1	0.1	-0.8
Medication: Cholesterol lowering	0.8	1.3	3.4	0.6	-1.0	-0.8	0.9	1.6	-0.7	1.8
Depression (self-reported)	0.7	0.9	1.7	-0.6	-0.6	-0.8	-1.3	-0.9	-1.1	-1.1
Medication: Lansoprazole	0.3	0.3	1.2	0.3	0.1	-0.4	-0.5	-0.5	-1.1	-0.4
Prospective memory result	1.4	1.7	4.5	2.1	-0.6	0.2	1.6	1.1	0.5	1.7
Lung cancer (father)	0.6	0.7	1.6	1.0	1.2	0.9	0.9	0.2	0.3	0.6
Illnesses of mother	1.1	1.4	3.6	1.3	1.7	-1.9	-0.2	-0.2	-1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	-0.8	-0.4	-0.4	-0.2	0.7	0.6	0.4
Pulse wave Arterial Stiffness index	1.3	1.5	3.3	-1.8	-0.6	0.6	-1.6	-0.9	0.5	-1.7
Impedance of arm (left)	1.5	6.9	18.4	1.9	0.0	1.2	4.3	2.4	3.3	2.8
Arm fat mass (right)	0.9	3.8	10.5	-2.3	0.2	0.7	-3.2	-1.9	-1.3	-2.2
Trunk predicted mass	0.5	3.1	7.4	-0.8	1.3	0.0	-2.7	-2.0	-1.6	-2.3
Standing height	0.0	0.4	0.9	0.3	0.9	0.9	0.5	-0.4	1.0	-0.3
Length of working week for main job	0.4	0.4	1.0	-0.1	-0.8	-0.5	0.4	0.9	-0.5	1.0
Exposure to tobacco smoke at home	1.0	1.2	5.4	-0.4	-1.3	0.1	0.2	0.9	-2.3	0.2
Breastfed as a baby	2.1	2.6	6.6	-0.6	1.0	1.5	-1.9	-2.6	-0.6	-2.1
Tense / ‘highly strung’	0.8	1.3	2.4	-0.9	-1.6	0.9	1.4	1.0	1.3	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.6	-0.6	-1.6	-0.3	-0.8	-0.4	-1.6	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	-0.8	-0.9	-0.9	0.3	1.2	-0.4	0.1
Birth weight of first child	0.5	1.0	3.5	1.0	-0.0	-1.4	0.1	0.3	-1.9	0.6
Peak expiratory flow (PEF)	0.4	0.9	4.1	-0.4	-0.2	1.5	0.1	0.3	2.0	-0.1
Pulse wave reflection index	2.6	3.3	6.6	-2.1	-0.9	1.5	-2.6	-1.6	0.2	-2.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.0	-1.5	-0.3	0.8	-1.4	-0.7	-0.5	-1.7
Loud music exposure frequency	0.4	0.5	1.7	0.8	0.4	0.1	-0.8	-0.5	1.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.5	0.4	-1.5	0.5	-0.8	-1.9	1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	1.4	1.2	0.2	-1.2	0.8	1.2	1.1	0.9
Blood clot in the leg (DVT)	0.4	0.5	1.1	1.1	0.8	-0.8	-0.4	0.4	-0.8	0.7
Medication: Paracetamol	0.9	1.5	3.5	-1.2	-0.1	0.9	-1.9	-1.9	-0.0	-1.2
Headache pain in last month	1.0	1.7	3.8	-1.8	0.6	0.8	-2.0	-1.2	0.6	-1.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.9	-0.2	0.6	1.1	-0.3	-0.7	1.7	-1.0
Glaucoma (self-reported)	0.1	0.1	0.3	-0.4	-0.0	0.4	-0.3	0.1	-0.2	0.5
Gout (self-reported)	0.4	0.5	2.2	-0.4	0.6	-0.6	-0.5	-0.3	-1.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.5	0.4	1.9	-0.9	0.6	0.5	-0.5	0.2
Medication: Amlodipine	0.8	1.1	2.4	-0.2	-1.2	-1.1	0.7	1.6	1.3	0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	-0.8	0.0	0.5	-0.1	0.3	1.4	-0.5
Birth weight	1.3	2.9	8.5	-2.9	-2.8	1.3	-0.1	0.2	0.9	-1.1
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.2	0.0	-1.5	0.6	0.3	0.2	0.9	0.6
High blood pressure (siblings)	3.8	5.4	13.9	-3.7	-3.6	2.1	-1.3	0.4	1.8	-1.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.5	-0.3	-0.6	0.1	0.9	-0.1	0.8
Body fat percentage	0.7	2.7	6.3	-2.3	-0.1	1.2	-2.5	-1.4	-0.8	-1.7
Leg fat percentage (right)	1.1	4.0	8.8	-2.8	-0.3	1.0	-3.0	-1.5	-1.4	-2.4
Arm fat-free mass (right)	0.9	4.6	11.7	-1.3	0.6	-0.1	-3.4	-2.5	-2.4	-2.4
Exposure to tobacco smoke outside home	0.2	0.3	0.9	-0.4	0.4	0.1	-0.0	0.7	-1.0	0.3
Comparative body size at age 10	0.9	2.5	5.5	-0.4	0.8	-1.6	-2.3	-2.2	-0.9	-1.6
Number of full brothers	0.8	1.1	2.4	0.7	-0.4	0.8	1.2	1.5	1.3	0.8
Worry too long after embarrassment	1.8	3.0	5.1	-1.6	-0.1	2.3	-2.2	-1.4	1.3	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.0	-1.3	-0.9	1.2	-0.8	-0.6	0.8	-1.4
Wheeze or whistling in the chest in last year	0.4	0.7	3.1	-1.8	-0.2	0.1	-1.0	-0.3	-0.5	-0.7
Number of children fathered	0.4	0.4	2.2	0.0	1.5	-0.2	0.2	-0.3	0.7	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	5.7	0.6	0.0	-0.7	1.9	2.4	1.0	1.5
Age at first live birth	0.2	0.3	1.1	1.0	0.0	-0.2	0.4	-0.5	0.6	0.8
Pulse wave peak to peak time	1.2	1.4	3.5	1.9	0.6	-0.6	1.6	0.7	-0.4	1.6
Health satisfaction	0.7	0.9	3.1	-1.8	0.2	0.9	0.0	0.1	0.8	-1.3
Shortness of breath walking on level ground	1.7	2.0	4.1	-2.0	1.7	1.6	-0.7	-1.0	0.3	-1.8
Qualifications: College or University degree	0.6	2.0	4.5	2.1	1.7	-1.3	2.0	0.1	0.0	1.1
Eye problems/disorders: None of the above	2.0	2.3	4.8	0.9	-0.4	-1.9	2.1	2.2	0.7	1.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.5	1.0	-0.4	-0.2	1.2	1.9	-1.0	1.4
Emphysema/chronic bronchitis	0.7	0.7	3.2	-0.8	0.5	1.8	0.1	-0.4	1.0	-0.2
Medication for pain relief, constipation, heartburn	0.6	1.1	2.2	1.1	1.4	-0.6	1.5	1.1	0.7	0.5
Neck or shoulder pain in last month	1.2	1.7	3.6	0.5	0.4	-1.2	1.5	1.9	1.5	1.3
Medication: Blood pressure	0.6	1.0	4.4	-0.0	-1.1	-1.1	-0.1	-0.2	-2.1	0.5
Angina (self-reported)	0.9	1.2	5.0	-0.1	-2.2	0.6	0.7	1.2	0.1	1.0
Migraine (self-reported)	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.3	0.5	-0.3	-0.1
Medication: Ibuprofen	0.2	0.2	0.6	-0.7	-0.4	0.7	-0.4	0.0	-0.1	-0.5
Medication: Allopurinol	0.3	0.4	1.0	0.7	0.6	-0.5	0.6	0.3	-0.2	1.0
Medication: Omeprazole	0.4	0.5	1.2	-0.2	-1.1	-0.4	-0.6	-1.0	-1.0	0.1
Medication: Seretide 50 evohaler	0.5	0.5	1.4	-0.7	1.1	0.5	0.3	0.4	1.2	-0.3
Mean time to correctly identify matches	0.3	0.5	1.6	1.2	-0.9	-0.7	-0.1	0.5	-0.5	0.3
Heart disease (mother)	0.7	0.8	4.3	-0.1	-0.3	2.1	0.6	-0.1	1.0	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.2	-0.4	-0.9	0.6	-0.1	0.0	1.5	-0.1
Whole body fat mass	0.9	3.8	9.9	-2.4	0.1	0.9	-3.1	-1.9	-1.4	-2.1
Leg fat mass (right)	1.4	5.4	13.6	-2.9	-0.3	1.0	-3.7	-2.1	-1.8	-2.6
Arm predicted mass (right)	0.8	4.2	11.0	-1.4	0.6	0.1	-3.3	-2.5	-2.3	-2.3
Pulse rate, automated reading	0.3	0.8	2.3	-1.3	0.1	0.5	-0.5	-0.2	1.5	-1.1
Alcohol intake frequency.	1.9	4.5	12.0	1.8	2.1	-3.5	1.8	1.6	-1.6	1.9
Comparative height size at age 10	0.2	0.8	2.1	-0.4	0.6	1.4	0.9	0.6	1.3	-0.6
Number of full sisters	1.3	1.5	7.0	0.4	-0.1	0.6	1.2	2.6	0.6	1.2
Suffer from ‘nerves’	1.4	2.2	4.1	-1.3	-0.2	1.6	-2.0	-2.0	-0.4	-1.7
Overall health rating	0.9	2.0	7.7	-2.8	-0.6	1.3	-0.9	-0.2	1.2	-1.4
Chest pain or discomfort	0.3	0.4	1.1	-0.7	1.1	-0.4	-0.9	-0.2	-0.5	-0.3
Had major operations	4.9	5.7	11.8	-2.7	-3.4	0.9	-3.0	-1.5	-2.8	-1.1
Age at last live birth	0.3	0.4	1.8	0.7	0.3	0.4	0.2	-0.2	1.4	0.3
Family relationship satisfaction	0.9	1.1	2.5	-0.8	0.5	1.6	-0.7	-1.1	0.1	-1.5
Leg pain on walking	0.2	0.3	0.7	0.3	0.7	-0.8	0.1	-0.4	0.4	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.0	-0.8	-1.3	1.4	-0.3	0.3	0.6	-0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.0	-0.7	1.4	0.0	-0.2	-0.2	1.4	-1.2
Illness, injury, bereavement, stress in last 2 years	4.1	5.0	11.6	3.4	0.5	-3.1	2.0	0.4	-2.0	2.4
Medication: Aspirin	1.0	1.3	5.4	-0.4	-2.3	-1.0	-0.5	0.5	-1.2	1.0
Supplements: Vitamin C	1.5	1.8	4.6	-0.4	-0.7	1.6	-1.8	-2.1	0.2	-1.2
Knee pain experienced in last month	0.8	1.2	2.3	-1.4	0.3	1.5	-1.5	-0.6	0.8	-0.8
Hypertension (Self-reported)	0.8	2.3	6.4	-1.6	-1.4	-0.2	-1.8	-0.9	-2.5	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.3	-1.0	0.1	0.4	0.3	-0.1	0.2
Illnesses of father: Heart disease	0.9	1.2	2.2	-1.5	-1.2	0.4	-1.2	-0.5	-1.2	-1.4
Illnesses of siblings: Diabetes	1.1	1.3	1.8	-1.3	-0.4	1.3	-1.3	-0.9	1.2	-1.2
Smoking status: Previous	0.8	1.2	2.6	0.5	0.6	0.8	1.2	1.4	1.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.8	0.4	0.9	-0.3	0.5	0.6	0.5	0.6
Whole body fat-free mass	0.8	4.4	11.2	-1.3	1.3	0.1	-3.4	-2.6	-2.0	-2.4
Leg fat-free mass (right)	0.8	4.3	11.1	-1.2	1.7	0.2	-3.3	-2.7	-1.6	-2.1
Arm fat percentage (left)	0.6	2.4	5.8	-1.9	0.7	1.2	-2.4	-1.6	-0.5	-1.7
Average weekly red wine intake	0.3	0.4	1.7	-0.3	-1.3	0.8	0.5	-0.1	0.1	-0.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.9	0.3	-0.9	-1.7	-0.5	-0.3	-0.5	0.3
Mood swings	0.6	1.2	2.0	-1.4	-1.1	1.4	-1.4	-0.5	-0.4	-0.8
Loneliness, isolation	0.9	1.3	2.7	-0.4	1.3	1.7	-0.9	-0.7	-0.8	-1.5
Long-standing illness, disability or infirmity	0.9	1.3	2.6	-0.8	0.4	0.6	-1.5	-1.6	-1.2	-1.3
Ever had bowel cancer screening	0.5	0.6	2.4	-0.6	0.1	1.6	-0.3	-0.5	0.8	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.8	0.6	0.9	-0.2	0.4	-0.5	-0.4	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.7	-0.2	-2.2	-0.7	0.8	1.7	0.0	0.5
Friendships satisfaction	0.2	0.3	1.1	-0.1	0.2	-1.0	0.3	-0.0	-0.8	-0.3
Qualifications: nursing, teaching	0.8	1.3	3.3	0.8	1.2	-0.1	1.8	-0.0	1.7	0.9
Commuting to job workplace: Walk	0.8	0.9	2.3	1.0	-1.5	-0.1	0.2	0.0	-1.1	1.2
Eye problems/disorders: Cataract	0.5	0.6	2.4	-0.3	0.4	1.5	-0.2	-1.1	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	-0.1	-0.6	-1.0	0.2	1.2	0.4	0.5
Medication for cholesterol	0.4	0.6	3.3	0.9	1.8	0.5	0.3	-0.1	0.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.5	-0.4	0.4	-0.2	-0.2	-1.1	-1.2	-0.3
Back pain experienced in last month	1.0	1.5	4.0	0.8	0.5	1.8	1.4	0.6	2.0	0.7
Mineral and other dietary supplements	2.2	3.0	6.6	-2.6	-0.4	0.2	-2.5	-1.1	-0.5	-2.5
Breast cancer (self-reported)	0.3	0.3	0.7	0.5	0.6	-0.1	-0.8	-0.8	0.8	0.1
Asthma (self-reported)	0.6	1.2	4.1	-0.5	1.1	0.4	0.9	1.3	2.0	-0.1
Osteoporosis (self-reported)	0.8	1.0	2.6	1.6	0.8	1.6	0.3	-0.2	-0.6	0.7
Osteoarthritis (self-reported)	0.6	0.8	2.6	1.3	-0.5	-0.4	0.4	0.3	-0.9	1.6
Medication: Aspirin	0.9	1.2	5.3	-0.8	-2.3	-0.1	-1.2	-0.3	-0.9	0.5
Medication: Gliclazide	0.7	0.8	1.8	1.3	1.2	-0.9	0.7	0.3	-0.2	1.1
Illnesses of father: None of the above (group 1)	0.9	1.1	3.8	0.5	0.9	1.9	0.9	0.1	1.5	-0.1
Smoking status: Current	2.2	3.5	9.1	-1.7	0.5	0.3	-2.6	-1.7	-3.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.8	-0.8	-0.4	1.4	0.5	0.8	2.0	0.2
Whole body water mass	0.7	3.8	9.7	-1.1	1.1	-0.0	-3.1	-2.4	-1.9	-2.2
Leg predicted mass (right)	0.8	4.3	11.1	-1.2	1.7	0.2	-3.3	-2.7	-1.6	-2.1
Arm fat mass (left)	0.9	3.7	9.8	-2.1	0.3	1.0	-3.1	-2.1	-1.2	-2.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.2	-0.6	-0.2	0.1	0.6	-0.1	0.8
Average weekly champagne plus white wine intake	0.7	1.0	1.5	-0.9	-1.2	0.8	-0.9	-0.7	1.2	-1.1
Miserableness	2.1	3.7	10.6	-2.1	0.2	0.8	-3.2	-2.2	-0.2	-2.2
Guilty feelings	1.3	1.9	3.7	-1.0	0.0	1.7	-1.9	-1.5	0.8	-1.6
Wears glasses or contact lenses	0.8	0.9	1.7	0.4	-1.0	0.1	1.3	1.3	0.8	1.0
Ever taken oral contraceptive pill	0.4	0.5	1.2	1.1	-1.1	-0.4	0.2	-0.1	0.2	0.9
Hearing aid user	0.7	0.7	1.7	-1.3	0.7	0.2	-0.4	-0.5	1.3	-1.0
Mother’s age at death	0.6	0.8	2.0	-0.9	1.4	1.1	-0.9	-0.6	0.2	-0.5
Financial situation satisfaction	0.4	0.5	1.1	-1.0	0.0	-0.5	-0.6	-0.6	-1.0	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.7	0.6	0.5	-1.1	-0.5	-0.2	-1.3	0.6
Commuting to job workplace: Public transport	0.7	0.8	2.7	0.7	-0.5	0.4	-0.6	-1.2	-1.6	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	-0.2	-0.1	0.0	0.1	0.3	-0.4	0.7
Medication: Blood pressure	1.0	2.0	5.6	-2.4	-2.2	-0.2	-1.1	0.1	0.6	-1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.2	-1.1	0.7	0.1	-0.4	-0.0	0.7	-0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.8	4.6	1.8	-0.0	0.0	2.0	0.6	-0.2	2.1
High cholesterol (Self-reported)	0.3	0.5	2.1	-0.6	-0.0	0.2	1.0	1.4	-0.3	0.2
Medication: Bendroflumethiazide	1.0	1.6	3.1	-1.5	-0.6	-0.3	-1.8	-1.7	-0.4	-1.5
Medication: Paracetamol	0.6	1.0	2.2	-1.1	0.1	0.6	-1.4	-1.5	-0.4	-0.9
Medication: Lisinopril	0.6	0.8	3.0	-1.1	-0.4	-0.8	-0.7	-0.5	-1.7	-0.3
Medication: Atorvastatin	0.4	0.5	2.2	-0.4	0.4	-0.5	-1.5	-0.6	-0.6	-0.5
Illnesses of father: High blood pressure	1.0	1.2	2.7	-1.6	-1.5	-0.2	-1.3	-1.1	0.1	-0.7
Alcohol drinker status: Never	0.6	0.8	4.2	0.6	2.0	-0.9	-0.1	-0.1	-0.2	-0.3
Ever smoked	0.4	0.8	3.5	0.4	1.9	0.7	0.4	0.2	1.0	0.4
Basal metabolic rate	0.9	4.8	12.5	-1.4	1.1	0.1	-3.5	-2.6	-2.0	-2.5
Leg fat percentage (left)	1.1	3.9	9.5	-2.6	-0.1	0.8	-3.1	-1.7	-1.4	-2.3
Arm fat-free mass (left)	0.9	4.7	12.4	-1.5	0.3	-0.1	-3.5	-2.3	-2.5	-2.5
Number of operations (self-reported)	2.0	2.9	9.0	-3.0	-2.2	1.5	-1.5	-0.5	0.0	-1.3
Average weekly beer plus cider intake	1.5	2.2	6.0	-0.9	-0.4	0.3	-2.4	-1.6	-2.3	-0.8
Irritability	2.4	4.1	9.1	-1.6	0.9	1.2	-3.0	-3.0	-1.0	-2.3
Risk taking	1.6	2.3	7.5	-0.4	-0.3	0.3	-2.2	-1.4	-2.7	-1.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	-0.6	-0.5	0.6	-0.2	-0.8	-0.1	0.0
Fractured/broken bones in last 5 years	1.8	2.4	5.1	-0.8	2.3	1.4	-1.8	-1.5	-0.0	-1.9
Age started oral contraceptive pill	0.5	0.6	2.8	0.6	-0.3	1.7	-0.0	-1.1	-0.1	-0.2
Diastolic blood pressure, automated reading	0.6	2.0	5.1	-1.5	-1.7	-0.3	-2.3	-1.2	-1.3	-0.7
Ever depressed for a whole week	1.0	1.2	6.3	0.7	-2.5	-0.1	0.5	0.1	-1.1	0.5
Unable to work because of sickness or disability	1.3	1.7	3.6	-1.5	-0.0	1.4	-1.6	-0.4	-1.2	-1.9
Commuting to job workplace: Cycle	0.4	0.4	1.1	1.1	0.2	-0.3	0.3	0.2	1.0	0.8
Myopia	0.1	0.2	0.4	-0.6	0.0	-0.6	-0.4	-0.3	0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.9	2.5	3.9	1.9	2.0	-0.8	1.9	0.9	1.8	1.3
Cholesterol lowering medication	0.2	0.2	0.7	-0.4	-0.3	-0.8	-0.2	0.0	-0.8	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.3	-1.1	-0.0	-0.3	-0.9	-0.6	0.1
Pain experienced in last month	0.2	0.3	0.8	0.6	-0.0	-0.7	0.2	-0.4	-0.9	0.1
Supplements: Calcium	0.5	0.5	0.8	0.8	0.5	0.9	0.9	0.8	0.5	0.1
Basal cell carcinoma (self-reported)	1.0	1.2	3.2	-0.9	-1.3	1.8	0.3	0.3	1.4	-0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.5	-0.5	-1.6	0.9	0.3	1.0	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	0.9	0.7	-0.7	-0.4	0.4	-0.9	0.6
Heart disease (siblings)	0.6	0.8	3.9	-0.6	-2.0	-0.5	0.1	0.0	-0.7	0.7
Alcohol drinker status: Previous	1.2	1.4	2.8	0.4	0.0	-1.7	1.0	1.5	-1.1	1.4
Pack years of smoking	0.3	0.4	1.1	-0.6	0.2	1.0	-0.2	-0.5	0.6	-0.9
Impedance of whole body	0.9	4.5	12.5	1.1	-1.3	0.7	3.5	2.3	2.3	2.3
Leg fat mass (left)	1.3	4.9	12.9	-2.7	-0.0	0.8	-3.6	-2.1	-1.7	-2.5
Arm predicted mass (left)	0.8	4.3	11.2	-1.2	0.4	-0.1	-3.4	-2.3	-2.5	-2.4