Hub : Genes

TWF2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1424 0.0696 6.9e-03 0.091 NA 0.020 NA 0.083 3.7e-04 NA 6.1e-02 NA 6.6e-04
2 GTEx Cells Transformed fibroblasts 0.0700 0.0350 3.5e-03 0.032 NA 0.022 NA 0.032 1.9e-03 NA 8.1e-03 NA 1.9e-03
3 GTEx Thyroid 0.0980 0.0350 2.4e-06 0.066 NA 0.079 NA 0.083 8.9e-06 NA 1.2e-06 NA 6.2e-07
4 TCGA Brain Lower Grade Glioma 0.0798 0.0404 1.1e-05 0.057 0.053 0.054 NA 0.053 4.5e-07 1.1e-06 9.0e-07 NA 1.0e-06
5 TCGA Lung Squamous Cell Carcinoma 0.0428 0.0247 1.9e-03 -0.001 0.025 0.021 NA 0.008 4.4e-01 6.3e-04 1.5e-03 NA 3.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.6 3.5 -0.4 1.4 -0.9 -1.3 -1.9
Bipolar Disorder or Schizophrenia 1.2 2.9 8.7 -0.4 1.6 -0.7 -1.6 -2.9
Depressed Affect (Nagel 2018) 0.2 0.5 0.8 -0.9 0.4 0.1 -0.9 0.8
Depression (Nagel 2018) 0.5 0.8 3.7 0.2 0.3 -0.2 -0.2 -1.9
Intelligence (Savage-Jansen 2018) 0.4 1.1 5.2 0.1 0.0 -0.3 0.4 2.3
Neuroticism (Nagel 2018) 0.4 0.9 2.0 -1.1 0.7 -0.2 -1.4 -0.9
Schizophrenia (2018) 0.7 1.4 5.3 -0.2 0.7 -0.2 -1.1 -2.3
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 0.4 -0.6 0.7 0.4 -0.2
Worry (Nagel 2018) 1.2 2.5 9.8 -0.4 0.8 -0.3 -1.3 -3.1
Alzheimer’s Disease (in mother) 0.3 0.3 0.7 -0.5 0.5 -0.3 -0.9 0.6
Alzheimer’s Disease (in father) 1.0 1.1 1.7 1.1 -0.9 1.3 1.3 -0.2
Alzheimer’s Disease (including proxy) 0.1 0.2 0.5 0.3 -0.5 0.7 0.1 0.4
Crohns Disease (2017) 0.7 1.5 2.4 1.0 -1.6 1.3 0.9 -1.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 -0.1 -0.3 0.1 -0.2 -0.6
Ulcerative Colitis (UC) 0.3 0.5 0.7 -0.8 0.7 -0.8 -0.9 0.1
Major Depression (MDD) 1.4 1.7 3.8 1.4 -0.7 1.1 0.9 -1.9
Reaction Time 0.3 0.5 1.1 0.5 -0.9 1.0 0.7 0.0
Verbal and Numeric Reasoning (VNR) 0.8 1.9 9.1 -0.5 0.3 -0.4 -0.0 3.0
Breast Cancer 0.8 2.0 3.1 -1.5 1.2 -1.3 -1.3 1.8
Ovarian Cancer 0.8 1.1 1.9 -0.8 1.2 -1.4 -1.1 -0.3
Prostate Cancer 0.2 0.3 0.9 -0.1 0.5 0.3 -0.0 -1.0
Age at First Birth 1.6 2.3 3.5 1.9 -1.3 1.5 1.9 -0.8
Bipolar Disorder (2011) 0.4 0.3 1.4 -0.3 0.0 0.3 -0.4 -1.2
Body Mass Index (BMI) (2010) 1.4 1.9 2.9 -1.7 1.2 -1.3 -1.5 1.2
Coronary Artery Disease (CAD) 0.0 0.0 0.1 -0.3 0.1 -0.3 -0.2 0.1
Crohns Disease (2012) 0.8 1.3 2.2 1.0 -1.3 1.1 0.8 -1.5
Mean Putamen Volume 1.4 1.6 3.4 1.2 -1.2 0.9 0.9 -1.8
Fasting Glucose 2.4 2.9 4.0 -1.9 1.7 -2.0 -1.9 0.7
HbA1C 0.6 0.6 0.9 0.9 -0.9 1.0 0.7 -0.4
HDL Cholesterol 2.2 3.7 6.5 0.7 -2.4 2.5 1.4 2.0
LDL Cholesterol 0.1 0.2 0.8 -0.1 0.2 -0.9 0.2 -0.5
Lupus 0.1 0.2 0.6 0.1 -0.4 0.0 0.3 -0.8
Neuroticism (2016) 0.5 0.7 1.8 -1.0 0.6 -0.4 -1.3 -0.5
Primary Biliary Cirrhosis 0.3 0.4 0.8 0.8 -0.6 0.4 0.9 -0.4
Rheumatoid Arthritis 3.7 5.1 6.9 2.6 -2.2 2.3 2.6 -1.4
Schizophrenia (2014) 1.2 2.7 6.3 -0.7 1.6 -1.1 -1.8 -2.5
Triglycerides 4.3 7.1 11.5 -2.5 3.2 -3.4 -2.7 0.2
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.7 -0.5 1.2 -1.1 -1.1 -1.9
Ulcerative Colitis 0.1 0.2 0.4 -0.4 0.2 -0.1 -0.6 -0.6
Blood Eosinophil Count 0.0 0.3 0.8 0.2 0.6 -0.9 0.7 -0.1
Blood Platelet Count 0.1 1.3 5.2 0.2 -0.8 0.3 0.6 2.3
Blood Red Count 0.5 5.0 17.9 -1.0 1.5 -1.4 -1.3 -4.2
Blood White Count 0.9 6.5 13.1 -1.8 3.6 -3.4 -2.1 0.1
Heel T-Score 0.0 0.1 0.2 -0.1 -0.1 -0.3 0.1 -0.5
BMI 3.1 17.9 47.5 -3.6 3.5 -2.9 -2.8 6.9
Height 0.4 7.2 14.3 1.6 -2.8 3.8 2.0 -2.7
Waist Hip Ratio (WHR) 5.2 23.3 31.8 -2.8 5.6 -5.6 -3.9 -5.5
Systolic Blood Pressure 0.1 0.3 1.5 -0.0 0.1 -0.4 0.2 1.2
Smoking Status 1.5 3.7 5.9 -1.6 1.7 -2.1 -1.7 2.4
Allergy or Eczema 0.0 0.0 0.1 0.2 -0.3 0.2 0.3 -0.0
Cardiovascular Disease 0.7 2.3 4.6 -1.1 1.6 -1.5 -0.9 2.2
Hypothyroidism (self reported) 1.0 2.3 3.3 1.5 -1.6 1.8 1.8 0.3
Respiratory disease 0.2 0.4 0.7 -0.7 0.2 -0.2 -0.8 0.7
Type 2 Diabetes (T2D) (2018) 0.8 1.5 3.0 -0.9 1.4 -1.2 -0.7 1.7
Lung FEV1/FVC ratio 0.2 0.8 1.4 0.9 -0.8 0.8 1.2 0.9
Lung FVC 1.6 8.3 10.4 3.2 -2.8 2.2 2.9 -3.2
Neuroticism 0.5 1.3 2.8 -1.3 1.3 -0.6 -1.7 -0.1
Chronotype (morning person) 6.1 14.2 17.0 -3.9 4.0 -4.1 -3.9 2.7
Hair Pigment 0.0 1.0 3.5 -0.7 0.7 -0.6 -0.6 1.9
Tanning 0.1 1.1 4.5 0.4 -0.6 0.5 0.5 2.1
Hand grip strength (left) 0.1 0.2 0.4 0.0 -0.4 0.6 0.3 0.4
Number of treatments/medications taken 3.6 6.5 8.6 -2.5 2.9 -2.8 -2.7 1.6
Average weekly spirits intake 1.3 1.6 6.1 -0.9 0.6 -0.4 -0.5 2.5
Sensitivity / hurt feelings 0.2 0.4 0.6 -0.6 0.7 -0.7 -0.8 0.1
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.2 -0.5 0.8 -0.8 -0.9 -1.5
Hearing difficulty/problems: Yes 1.5 2.2 8.6 1.2 -0.4 0.2 0.8 -2.9
Relative age of first facial hair 1.6 3.3 3.8 2.0 -1.9 1.8 1.9 -1.4
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.0 0.2 0.2 -0.2 0.0 -1.4
Ever used hormone-replacement therapy (HRT) 6.7 8.5 12.3 -2.9 3.4 -3.5 -3.1 0.6
Ever had hysterectomy (womb removed) 4.2 4.8 7.8 -2.0 2.7 -2.8 -2.1 0.7
Systolic blood pressure, automated reading 0.3 0.8 1.2 0.8 -0.9 0.9 1.1 0.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.0 0.2 0.4 -0.3 0.2 -1.0
Angina 0.0 0.0 0.0 0.1 0.1 -0.0 -0.1 -0.1
Medication for hormone replacement therapy 1.1 1.2 2.4 -0.6 1.5 -1.6 -0.8 -0.7
Vitamin and mineral supplements 0.2 0.3 0.9 0.5 -0.4 0.5 0.3 -1.0
Supplements: Zinc 0.3 0.3 1.0 0.2 0.6 -0.5 -0.2 -1.0
Medication: Co-codamol 0.3 0.4 1.2 0.2 0.5 -0.7 -0.1 -1.1
Medication: Metformin 0.1 0.2 0.5 -0.2 0.5 -0.1 0.0 0.7
Diabetes (father) 0.9 1.2 2.0 -0.9 1.4 -1.3 -0.9 0.6
Diabetes (mother) 0.2 0.3 0.6 -0.5 0.6 -0.8 -0.5 0.1
Severe depression (siblings) 0.7 0.8 1.2 -0.7 1.0 -1.1 -0.9 -0.8
Pack years adult smoking proportion 0.4 0.7 2.6 -0.1 0.6 -0.5 -0.4 -1.6
Impedance of leg (right) 0.8 3.9 17.7 0.8 -0.9 0.4 0.3 -4.2
Leg fat-free mass (left) 0.7 3.6 10.2 -1.7 1.6 -1.0 -1.2 3.2
Trunk fat percentage 1.0 3.9 4.9 -2.2 2.1 -1.6 -1.8 2.0
Hand grip strength (right) 0.5 1.5 2.6 0.3 -1.3 1.6 0.8 1.5
Townsend deprivation index at recruitment 0.1 0.1 0.4 0.1 0.0 -0.2 0.1 -0.6
Current tobacco smoking 0.1 0.1 0.3 0.2 0.2 -0.2 0.0 -0.6
Average weekly fortified wine intake 0.3 0.4 0.7 0.3 -0.6 0.9 0.6 0.5
Maternal smoking around birth 0.4 0.6 2.4 0.7 -0.1 0.2 0.5 -1.6
Fed-up feelings 0.8 1.5 2.0 -1.4 1.4 -1.0 -1.4 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 3.4 0.5 -0.1 -0.1 0.0 -1.9
Relative age voice broke 0.2 0.4 0.7 0.7 -0.6 0.5 0.8 0.1
Taking other prescription medications 1.2 1.9 2.8 -1.2 1.7 -1.6 -1.4 -0.9
Age when periods started (menarche) 4.8 11.5 17.6 3.1 -4.2 4.1 3.7 0.6
Bilateral oophorectomy (both ovaries removed) 9.7 11.2 15.1 -3.3 3.9 -3.8 -3.5 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.1 -1.4 1.0 -1.4 -1.1 0.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.6 0.6 -0.7 0.7 0.2 -1.3
Qualifications: CSEs or equivalent 0.2 0.2 0.7 -0.0 -0.3 0.5 0.0 0.9
Serious illness, injury or assault to yourself 1.9 2.3 3.9 -1.1 1.8 -2.0 -1.5 -1.0
High blood pressure 0.3 0.8 1.6 0.7 -0.7 0.8 0.9 1.3
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.2 -0.1 0.3 -0.4 -0.3 -0.4
Multivitamins +/- minerals 0.1 0.1 0.5 0.1 -0.0 -0.1 0.5 0.7
Stomach or abdominal pain in last month 1.2 1.4 1.9 -0.8 1.4 -1.3 -1.1 -1.3
Supplements: Glucosamine 0.2 0.3 0.7 -0.3 0.7 -0.8 -0.5 0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 5.5 0.6 0.1 -0.4 0.4 -2.3
Medication: Atenolol 0.1 0.2 0.5 -0.5 0.2 -0.2 -0.3 0.7
Medication: Levothyroxine sodium 2.4 4.1 5.7 2.1 -2.4 2.3 2.3 -0.5
Sitting height 0.1 0.5 1.6 0.1 -0.7 1.3 0.3 -0.3
Chronic bronchitis/emphysema (father) 2.2 2.5 3.5 1.6 -1.9 1.8 1.6 -0.8
High blood pressure (mother) 2.3 3.2 4.5 -1.9 2.1 -2.1 -1.9 0.3
Body mass index (BMI) 2.2 9.4 20.0 -2.6 3.1 -2.5 -2.1 4.5
Impedance of leg (left) 1.0 5.0 22.1 1.1 -1.1 0.5 0.5 -4.7
Leg predicted mass (left) 0.7 3.8 10.5 -1.7 1.7 -1.0 -1.2 3.2
Trunk fat mass 1.1 4.5 6.3 -2.3 2.3 -1.6 -1.9 2.5
Waist circumference 2.1 7.6 13.7 -2.6 3.7 -3.2 -2.5 1.1
Number of incorrect matches in round 0.3 0.5 1.1 -0.8 -0.2 0.5 -0.6 1.0
Past tobacco smoking 0.7 1.3 4.6 0.8 -0.5 0.9 0.6 -2.1
Alcohol usually taken with meals 0.8 1.4 2.0 -1.3 1.0 -1.4 -1.4 0.2
Nervous feelings 0.7 1.4 6.5 0.1 0.1 0.3 -0.4 -2.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.9 -0.7 0.7 -0.5 -1.2 -1.4
Hearing difficulty/problems with background noise 0.5 0.9 4.1 0.2 0.2 -0.3 -0.3 -2.0
Hair/balding pattern: Pattern 2 2.1 2.7 5.2 -1.7 1.3 -1.2 -1.4 2.3
Had menopause 0.5 0.6 0.8 0.8 -0.9 0.8 0.8 -0.5
Had other major operations 2.6 3.2 4.3 -1.9 2.0 -2.1 -1.8 1.0
Forced vital capacity (FVC) 0.5 2.1 5.1 1.2 -1.3 1.3 0.8 -2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 3.0 -1.4 1.3 -1.7 -1.2 0.7
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.5 -1.2 1.9 -1.7 -1.4 -0.5
Qualifications: None of the above 0.1 0.2 0.4 0.1 -0.4 0.7 0.1 0.7
Financial difficulties in last 2 years 1.0 1.4 2.6 -0.7 1.4 -1.6 -1.1 -0.8
Mouth/teeth dental problems 0.9 1.4 3.0 -1.2 0.8 -0.9 -1.1 1.7
Heart attack 0.3 0.3 0.9 -0.6 0.3 -0.3 -0.4 1.0
Allergy 0.1 0.3 0.6 0.6 -0.4 0.4 0.7 -0.0
Pain all over the body in last month 0.2 0.2 0.4 -0.5 0.4 -0.2 -0.4 -0.7
Diabetes (self-reported) 0.2 0.3 0.9 0.7 -0.3 0.5 0.9 0.1
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 0.0 -0.2 0.3 -0.1 -0.7
Medication: Ramipril 0.4 0.5 0.6 0.8 -0.8 0.5 0.7 -0.5
Medication: Simvastatin 1.2 1.8 4.5 -1.3 1.0 -0.6 -1.2 2.1
Fluid intelligence score 0.3 0.6 2.6 0.2 0.1 -0.2 0.4 1.6
Illnesses of siblings 0.1 0.1 0.3 -0.2 0.5 -0.3 -0.1 0.5
Neuroticism score 0.7 1.5 2.9 -1.4 1.4 -0.9 -1.7 -0.1
Weight 1.0 5.1 10.8 -2.1 2.3 -1.6 -1.6 3.3
Impedance of arm (right) 1.0 4.6 15.8 1.1 -1.8 1.4 0.8 -4.0
Arm fat percentage (right) 2.1 8.2 12.9 -2.8 2.9 -2.5 -2.4 3.6
Trunk fat-free mass 0.1 0.6 2.5 -0.4 0.6 -0.0 -0.2 1.6
Hip circumference 0.7 3.0 12.5 -1.1 1.0 -0.4 -0.5 3.5
Time employed in main current job 2.4 2.8 3.8 -1.6 1.9 -1.9 -1.7 1.2
Alcohol intake versus 10 years previously 1.5 2.3 3.2 1.6 -1.8 1.6 1.7 -0.1
Father’s age at death 1.1 1.5 2.1 1.2 -1.1 1.2 1.2 -1.5
Worrier / anxious feelings 0.8 1.6 5.8 -0.4 0.8 -0.6 -1.0 -2.4
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.5 3.3 -1.4 1.8 -1.7 -1.8 -1.0
Falls in the last year 0.5 0.7 1.2 -0.4 1.0 -1.1 -0.8 -0.5
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.3 0.2 -0.5 -0.3 0.1
Number of live births 0.1 0.1 0.2 -0.1 0.2 -0.3 -0.3 -0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.1 1.1 -1.2 1.1 0.9 -1.8
Pulse rate 1.1 1.9 2.8 -0.7 1.7 -1.4 -1.3 -1.6
Happiness 0.1 0.2 0.5 -0.4 -0.3 0.7 -0.3 -0.1
Noisy workplace 1.3 1.7 2.3 1.3 -1.4 1.5 1.5 -0.1
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.3 -0.2 -0.2 -0.1 -0.2 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.0 -0.3 0.9 -0.8 -0.7 -1.0
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 0.5 -0.3 0.4 0.4 -0.2
Asthma 0.8 1.6 2.1 -1.3 1.4 -1.4 -1.4 0.7
Medication: Ibuprofen (e.g. Nurofen) 4.0 5.1 6.6 -2.6 1.9 -2.0 -2.5 2.2
Medication: Cholesterol lowering 0.5 0.8 3.3 -0.7 0.2 -0.1 -0.4 1.8
Depression (self-reported) 0.8 0.9 1.5 -0.8 0.9 -0.8 -1.2 -1.0
Medication: Lansoprazole 3.2 3.6 5.2 -1.9 2.3 -2.3 -2.0 0.1
Prospective memory result 0.4 0.5 2.4 -0.2 0.1 0.2 -0.5 -1.5
Lung cancer (father) 0.0 0.0 0.1 -0.0 -0.1 0.2 0.0 0.3
Illnesses of mother 0.5 0.6 0.9 0.9 -0.9 0.7 0.9 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.7 0.9 -0.7 0.8 0.7 -1.6
Pulse wave Arterial Stiffness index 0.1 0.2 0.4 0.7 0.1 0.1 0.6 -0.2
Impedance of arm (left) 0.9 4.2 13.9 1.0 -1.9 1.5 0.7 -3.7
Arm fat mass (right) 1.7 7.0 11.6 -2.5 2.8 -2.2 -2.1 3.4
Trunk predicted mass 0.1 0.5 2.3 -0.4 0.5 0.1 -0.1 1.5
Standing height 0.2 2.0 5.2 0.6 -1.2 1.6 0.7 -2.3
Length of working week for main job 1.2 1.4 2.8 -1.1 1.1 -0.8 -1.0 1.7
Exposure to tobacco smoke at home 0.3 0.3 1.1 0.1 -0.2 0.4 0.2 1.1
Breastfed as a baby 6.1 7.6 10.9 2.7 -3.3 3.3 3.0 -0.5
Tense / ‘highly strung’ 0.3 0.6 1.1 -0.5 0.8 -0.2 -0.9 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.1 -1.3 1.4 -1.1 -1.4 0.2
Hair/balding pattern: Pattern 4 0.1 0.3 1.4 -0.2 0.0 0.1 -0.0 1.2
Birth weight of first child 0.0 0.0 0.1 -0.0 -0.3 0.1 0.0 0.0
Peak expiratory flow (PEF) 0.2 0.5 1.0 0.6 -0.8 1.0 0.5 -0.3
Pulse wave reflection index 1.1 1.4 4.2 -0.7 1.1 -0.7 -0.7 2.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.8 -0.2 0.9 -0.9 -0.4 0.5
Loud music exposure frequency 1.7 1.9 2.4 1.4 -1.5 1.5 1.3 -1.0
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.0 0.1 -0.1 0.1 -0.1 0.2
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 6.3 1.5 -0.8 0.8 1.2 -2.5
Blood clot in the leg (DVT) 0.3 0.3 0.7 -0.5 0.6 -0.4 -0.5 -0.9
Medication: Paracetamol 1.9 3.1 5.8 -1.4 2.4 -2.0 -1.8 -0.8
Headache pain in last month 1.6 2.7 4.0 -1.9 1.9 -1.6 -2.0 -0.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 3.1 0.6 -0.4 0.2 0.2 -1.8
Glaucoma (self-reported) 0.8 0.9 2.6 -0.3 0.8 -0.8 -0.8 -1.6
Gout (self-reported) 0.6 0.8 3.8 0.3 -0.0 0.2 0.2 -1.9
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 2.8 1.3 -1.6 1.7 1.5 0.3
Medication: Amlodipine 0.1 0.2 0.4 0.5 -0.0 0.1 0.5 -0.6
Medication: Ventolin 100micrograms inhaler 2.6 3.3 4.3 -1.7 1.9 -2.1 -2.0 1.2
Birth weight 0.4 0.8 1.1 0.8 -1.1 1.0 0.9 -0.7
Chronic bronchitis/emphysema (mother) 1.4 1.7 2.6 1.2 -1.2 1.3 1.0 -1.6
High blood pressure (siblings) 0.1 0.2 0.7 0.4 -0.1 -0.0 0.1 -0.8
Forced vital capacity (FVC), Best measure 0.5 1.7 5.1 1.0 -0.9 1.0 0.7 -2.3
Body fat percentage 1.5 6.1 7.4 -2.6 2.6 -2.2 -2.2 2.7
Leg fat percentage (right) 2.4 8.6 11.9 -2.8 3.1 -2.7 -2.4 3.5
Arm fat-free mass (right) 0.4 1.8 5.5 -1.1 1.3 -0.6 -0.7 2.4
Exposure to tobacco smoke outside home 0.3 0.3 0.6 -0.6 0.5 -0.3 -0.8 0.6
Comparative body size at age 10 1.2 3.3 4.5 -1.4 2.0 -2.1 -1.4 2.0
Number of full brothers 1.4 1.8 2.6 -1.4 1.1 -1.2 -1.3 1.6
Worry too long after embarrassment 1.9 3.2 4.8 -1.4 2.1 -2.2 -2.0 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 2.4 -1.3 1.5 -1.4 -1.5 -0.8
Wheeze or whistling in the chest in last year 1.1 2.0 3.1 -1.5 1.7 -1.3 -1.8 -0.3
Number of children fathered 2.7 3.1 3.4 -1.7 1.9 -1.8 -1.5 1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.3 -0.6 0.3 -0.2 -0.5 0.6
Age at first live birth 1.9 3.3 4.9 1.9 -2.0 1.9 2.2 -0.8
Pulse wave peak to peak time 0.1 0.1 0.4 -0.6 -0.1 0.0 -0.5 0.1
Health satisfaction 0.6 0.8 1.8 -0.5 1.3 -0.9 -0.9 -0.5
Shortness of breath walking on level ground 0.2 0.2 0.5 -0.5 0.4 -0.1 -0.7 0.2
Qualifications: College or University degree 0.3 0.9 1.9 -0.3 1.0 -1.0 -0.6 -1.4
Eye problems/disorders: None of the above 1.4 1.6 2.3 1.4 -1.5 1.3 1.5 -0.1
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.0 0.1 0.2 -0.3 -0.3
Emphysema/chronic bronchitis 4.8 5.4 7.1 2.3 -2.7 2.5 2.1 -1.9
Medication for pain relief, constipation, heartburn 3.8 6.6 9.3 2.6 -2.9 2.8 3.0 -0.6
Neck or shoulder pain in last month 0.4 0.5 2.1 0.2 0.6 -0.4 -0.1 -1.5
Medication: Blood pressure 0.3 0.6 1.9 0.3 -0.4 0.6 0.6 1.4
Angina (self-reported) 0.0 0.0 0.1 -0.1 0.2 -0.2 -0.3 0.0
Migraine (self-reported) 2.7 3.4 4.2 1.9 -1.6 2.0 2.0 -1.6
Medication: Ibuprofen 4.2 5.0 6.1 -2.5 1.9 -1.9 -2.4 2.4
Medication: Allopurinol 0.2 0.3 1.5 0.1 0.2 -0.1 -0.1 -1.2
Medication: Omeprazole 3.3 3.9 6.5 -1.7 2.4 -2.6 -2.0 -0.7
Medication: Seretide 50 evohaler 0.0 0.0 0.1 -0.1 0.4 -0.2 -0.1 0.1
Mean time to correctly identify matches 0.9 1.6 2.8 1.0 -1.7 1.7 1.2 -0.1
Heart disease (mother) 2.0 2.5 2.7 -1.5 1.6 -1.6 -1.6 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.8 -0.1 -0.4 0.2 0.0 0.9
Whole body fat mass 1.4 5.7 7.9 -2.4 2.6 -2.0 -2.0 2.8
Leg fat mass (right) 2.4 9.3 14.3 -2.9 3.2 -2.6 -2.5 3.8
Arm predicted mass (right) 0.2 1.2 4.2 -0.8 1.0 -0.4 -0.4 2.1
Pulse rate, automated reading 1.0 3.3 8.2 -0.3 2.0 -1.8 -1.1 -2.9
Alcohol intake frequency. 0.1 0.3 1.0 0.0 0.7 -0.3 -0.3 -1.0
Comparative height size at age 10 0.2 1.0 2.2 -0.7 0.8 -0.5 -1.0 -1.5
Number of full sisters 0.1 0.2 0.2 0.5 -0.4 0.4 0.4 -0.1
Suffer from ‘nerves’ 0.2 0.3 1.1 -0.1 -0.2 0.6 -0.4 -1.0
Overall health rating 0.9 1.9 3.1 -0.6 1.7 -1.4 -1.2 -1.7
Chest pain or discomfort 0.9 1.3 2.6 1.2 -0.8 1.0 0.8 -1.6
Had major operations 4.4 5.2 6.9 2.6 -2.1 2.0 2.5 -2.0
Age at last live birth 1.6 2.3 3.1 1.5 -1.6 1.5 1.8 -1.3
Family relationship satisfaction 0.4 0.5 1.6 0.4 -0.5 0.5 0.2 -1.3
Leg pain on walking 0.4 0.6 0.9 0.9 -0.4 0.6 0.9 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 0.1 0.2 -0.3 0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.3 -0.2 -0.2 0.3 -0.3 1.1
Illness, injury, bereavement, stress in last 2 years 2.9 3.5 5.5 1.6 -2.4 2.2 1.9 0.7
Medication: Aspirin 1.2 1.6 2.5 -1.4 1.0 -0.9 -1.3 1.6
Supplements: Vitamin C 0.1 0.1 0.4 0.1 -0.3 0.2 0.0 -0.7
Knee pain experienced in last month 1.1 1.7 2.2 -1.3 1.5 -1.4 -1.2 1.1
Hypertension (Self-reported) 0.2 0.7 1.3 0.6 -0.7 0.8 0.8 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 -0.4 0.7 -0.6 -0.5 0.0
Illnesses of father: Heart disease 0.0 0.0 0.1 0.1 -0.2 0.1 0.1 0.2
Illnesses of siblings: Diabetes 1.9 2.4 3.7 1.8 -1.3 1.4 1.9 -1.1
Smoking status: Previous 1.4 2.1 4.4 -1.4 1.1 -1.3 -1.2 2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.6 1.0 -1.0 1.3 0.8 -1.0
Whole body fat-free mass 0.2 1.4 4.6 -0.9 1.0 -0.4 -0.5 2.1
Leg fat-free mass (right) 0.6 3.0 8.3 -1.5 1.6 -1.0 -1.1 2.9
Arm fat percentage (left) 1.9 7.8 12.6 -2.7 2.8 -2.3 -2.3 3.6
Average weekly red wine intake 4.8 7.0 11.3 -2.6 2.4 -2.2 -2.5 3.4
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.1 0.2 -0.1 -0.3 -0.4
Mood swings 0.2 0.3 0.5 -0.7 0.5 0.0 -0.6 0.5
Loneliness, isolation 0.4 0.5 0.9 -0.9 0.5 -0.3 -1.0 0.7
Long-standing illness, disability or infirmity 3.0 4.6 7.6 -1.9 2.6 -2.8 -2.2 0.1
Ever had bowel cancer screening 0.1 0.2 0.3 -0.5 0.2 -0.2 -0.6 -0.4
Diabetes diagnosed by doctor 0.1 0.1 0.4 0.4 0.1 0.1 0.6 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 -0.6 1.1 -0.9 -0.6 0.0
Friendships satisfaction 0.8 1.0 2.2 0.9 -1.1 1.5 0.8 -0.3
Qualifications: nursing, teaching 1.3 2.0 3.1 -1.4 1.4 -1.8 -1.2 1.1
Commuting to job workplace: Walk 1.5 1.6 4.3 1.3 -0.6 0.5 1.2 -2.1
Eye problems/disorders: Cataract 0.3 0.4 0.5 -0.7 0.7 -0.6 -0.7 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 0.3 -0.3 0.2 0.5 -0.6
Medication for cholesterol 1.6 2.5 5.3 0.8 -2.1 2.3 1.4 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.9 -1.0 0.2 -0.2 -1.0 0.4
Back pain experienced in last month 0.1 0.1 0.2 0.3 0.5 -0.4 0.1 -0.2
Mineral and other dietary supplements 1.7 2.3 3.0 1.3 -1.7 1.7 1.5 -1.3
Breast cancer (self-reported) 0.0 0.0 0.1 -0.2 0.1 -0.1 -0.3 -0.3
Asthma (self-reported) 0.8 1.6 2.3 -1.3 1.4 -1.3 -1.5 0.7
Osteoporosis (self-reported) 0.5 0.6 1.3 0.8 -0.6 0.5 0.6 -1.1
Osteoarthritis (self-reported) 1.9 2.5 4.2 -1.5 2.0 -1.7 -1.5 1.1
Medication: Aspirin 0.9 1.2 1.9 -1.2 0.8 -0.7 -1.1 1.4
Medication: Gliclazide 0.4 0.5 0.7 -0.7 0.8 -0.7 -0.5 0.6
Illnesses of father: None of the above (group 1) 1.6 1.9 2.7 -1.4 1.6 -1.5 -1.5 0.6
Smoking status: Current 0.0 0.0 0.1 0.0 0.2 -0.3 0.0 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.8 1.0 -1.0 0.8 0.9 -1.4
Whole body water mass 0.3 1.8 5.4 -1.1 1.2 -0.6 -0.8 2.3
Leg predicted mass (right) 0.6 3.1 8.2 -1.5 1.6 -1.0 -1.1 2.9
Arm fat mass (left) 1.9 7.8 13.4 -2.7 2.9 -2.2 -2.2 3.7
Number of self-reported non-cancer illnesses 0.9 1.5 2.4 -1.1 1.4 -1.4 -1.6 0.2
Average weekly champagne plus white wine intake 0.7 0.9 1.5 0.4 -1.2 1.0 0.7 1.2
Miserableness 0.5 0.9 1.9 -1.0 0.6 -0.3 -1.0 1.4
Guilty feelings 0.6 0.9 2.7 0.7 -0.7 0.9 0.3 -1.6
Wears glasses or contact lenses 2.2 2.5 4.3 1.1 -2.1 2.0 1.4 0.9
Ever taken oral contraceptive pill 3.1 3.5 3.7 -1.9 1.9 -1.9 -1.9 1.8
Hearing aid user 0.4 0.4 0.7 -0.5 0.7 -0.7 -0.4 0.8
Mother’s age at death 5.9 7.4 10.1 2.6 -3.2 3.2 2.7 -1.7
Financial situation satisfaction 0.2 0.2 0.8 0.4 -0.3 0.3 0.1 -0.9
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.6 0.2 -0.0 0.3 0.0 -0.8
Commuting to job workplace: Public transport 1.5 1.7 2.3 -1.5 1.4 -1.5 -1.3 0.6
Eye problems/disorders: Glaucoma 0.8 1.0 3.9 0.7 -0.4 0.5 0.4 -2.0
Medication: Blood pressure 0.0 0.1 0.3 0.5 0.2 -0.3 0.2 0.1
Pain type(s) experienced in last month: Hip pain 5.0 6.3 8.5 -2.5 2.8 -2.9 -2.6 1.5
Supplements: Fish oil (including cod liver oil) 1.1 1.4 1.7 -1.1 1.2 -1.3 -1.3 1.0
High cholesterol (Self-reported) 0.3 0.5 1.8 -0.5 0.6 -0.3 -0.5 1.3
Medication: Bendroflumethiazide 0.1 0.1 0.2 0.5 0.0 0.2 0.5 -0.0
Medication: Paracetamol 1.3 1.9 3.3 -1.3 1.8 -1.5 -1.5 -0.2
Medication: Lisinopril 0.9 1.1 2.3 -1.0 1.1 -0.9 -0.5 1.5
Medication: Atorvastatin 0.5 0.6 1.0 1.0 -0.5 0.5 1.0 -0.9
Illnesses of father: High blood pressure 6.5 8.0 10.0 3.2 -2.9 3.0 3.0 -1.9
Alcohol drinker status: Never 1.4 1.7 2.4 -1.5 1.4 -1.3 -1.5 0.5
Ever smoked 0.4 0.7 1.4 0.5 -1.0 0.5 0.7 1.2
Basal metabolic rate 0.4 2.4 6.2 -1.4 1.5 -0.9 -1.0 2.5
Leg fat percentage (left) 2.2 7.9 11.0 -2.6 3.1 -2.6 -2.2 3.3
Arm fat-free mass (left) 0.4 2.1 4.6 -1.2 1.6 -0.9 -1.0 2.1
Number of operations (self-reported) 0.6 0.8 1.3 -0.8 1.1 -1.2 -0.9 0.0
Average weekly beer plus cider intake 2.2 3.2 4.5 2.0 -1.7 2.1 2.0 -0.4
Irritability 3.0 5.1 11.9 -2.3 1.7 -1.4 -2.0 3.5
Risk taking 2.6 3.8 6.8 -1.9 2.6 -2.3 -1.9 0.2
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.0 -1.1 0.3 -0.3 -0.9 1.4
Fractured/broken bones in last 5 years 0.8 1.0 1.7 1.3 -0.7 0.9 1.2 -0.8
Age started oral contraceptive pill 0.3 0.4 0.6 0.6 -0.7 0.8 0.5 -0.4
Diastolic blood pressure, automated reading 0.3 1.0 1.9 -0.7 1.4 -1.2 -1.0 -0.5
Ever depressed for a whole week 0.6 0.8 1.9 -0.5 1.4 -1.1 -0.7 0.1
Unable to work because of sickness or disability 0.4 0.6 1.8 0.7 -0.4 0.3 0.5 -1.3
Commuting to job workplace: Cycle 3.8 4.5 5.9 2.1 -2.4 2.4 2.3 -1.2
Myopia 0.1 0.1 0.3 -0.1 -0.1 -0.3 -0.2 0.5
Vascular/heart problems diagnosed by doctor 0.1 0.3 1.5 -0.2 0.1 -0.2 -0.3 -1.2
Cholesterol lowering medication 0.4 0.5 1.2 -0.4 1.1 -0.8 -0.8 0.3
Medication: Omeprazole (e.g. Zanprol) 2.5 3.1 5.3 -1.4 2.1 -2.3 -1.7 -0.9
Pain experienced in last month 1.3 2.1 4.0 1.2 -2.0 1.8 1.3 0.0
Supplements: Calcium 0.2 0.2 0.9 0.0 -0.1 -0.0 -0.2 -1.0
Basal cell carcinoma (self-reported) 1.9 2.2 3.0 -1.3 1.7 -1.6 -1.7 -0.9
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.7 -0.8 0.5 -0.5 -0.6 0.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.1 -0.2 0.4 -0.2 -0.2 -1.0
Heart disease (siblings) 0.9 1.1 2.0 -1.2 0.9 -0.8 -1.4 0.9
Alcohol drinker status: Previous 2.0 2.3 3.0 -1.7 1.5 -1.6 -1.7 0.9
Pack years of smoking 0.2 0.3 1.6 0.1 0.3 -0.1 -0.1 -1.3
Impedance of whole body 1.1 5.5 22.2 1.1 -1.6 1.1 0.6 -4.7
Leg fat mass (left) 2.3 9.1 13.8 -2.9 3.2 -2.6 -2.4 3.7
Arm predicted mass (left) 0.4 2.0 4.7 -1.2 1.5 -0.9 -0.9 2.2