Hub : Genes

TWF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1424	0.0696	6.9e-03	0.091	NA	0.020	NA	0.083	3.7e-04	NA	6.1e-02	NA	6.6e-04
2	GTEx	Cells Transformed fibroblasts	0.0700	0.0350	3.5e-03	0.032	NA	0.022	NA	0.032	1.9e-03	NA	8.1e-03	NA	1.9e-03
3	GTEx	Thyroid	0.0980	0.0350	2.4e-06	0.066	NA	0.079	NA	0.083	8.9e-06	NA	1.2e-06	NA	6.2e-07
4	TCGA	Brain Lower Grade Glioma	0.0798	0.0404	1.1e-05	0.057	0.053	0.054	NA	0.053	4.5e-07	1.1e-06	9.0e-07	NA	1.0e-06
5	TCGA	Lung Squamous Cell Carcinoma	0.0428	0.0247	1.9e-03	-0.001	0.025	0.021	NA	0.008	4.4e-01	6.3e-04	1.5e-03	NA	3.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.6	3.5	-0.4	1.4	-0.9	-1.3	-1.9
Bipolar Disorder or Schizophrenia	1.2	2.9	8.7	-0.4	1.6	-0.7	-1.6	-2.9
Depressed Affect (Nagel 2018)	0.2	0.5	0.8	-0.9	0.4	0.1	-0.9	0.8
Depression (Nagel 2018)	0.5	0.8	3.7	0.2	0.3	-0.2	-0.2	-1.9
Intelligence (Savage-Jansen 2018)	0.4	1.1	5.2	0.1	0.0	-0.3	0.4	2.3
Neuroticism (Nagel 2018)	0.4	0.9	2.0	-1.1	0.7	-0.2	-1.4	-0.9
Schizophrenia (2018)	0.7	1.4	5.3	-0.2	0.7	-0.2	-1.1	-2.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.4	-0.6	0.7	0.4	-0.2
Worry (Nagel 2018)	1.2	2.5	9.8	-0.4	0.8	-0.3	-1.3	-3.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	-0.5	0.5	-0.3	-0.9	0.6
Alzheimer’s Disease (in father)	1.0	1.1	1.7	1.1	-0.9	1.3	1.3	-0.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	0.3	-0.5	0.7	0.1	0.4
Crohns Disease (2017)	0.7	1.5	2.4	1.0	-1.6	1.3	0.9	-1.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.1	-0.3	0.1	-0.2	-0.6
Ulcerative Colitis (UC)	0.3	0.5	0.7	-0.8	0.7	-0.8	-0.9	0.1
Major Depression (MDD)	1.4	1.7	3.8	1.4	-0.7	1.1	0.9	-1.9
Reaction Time	0.3	0.5	1.1	0.5	-0.9	1.0	0.7	0.0
Verbal and Numeric Reasoning (VNR)	0.8	1.9	9.1	-0.5	0.3	-0.4	-0.0	3.0
Breast Cancer	0.8	2.0	3.1	-1.5	1.2	-1.3	-1.3	1.8
Ovarian Cancer	0.8	1.1	1.9	-0.8	1.2	-1.4	-1.1	-0.3
Prostate Cancer	0.2	0.3	0.9	-0.1	0.5	0.3	-0.0	-1.0
Age at First Birth	1.6	2.3	3.5	1.9	-1.3	1.5	1.9	-0.8
Bipolar Disorder (2011)	0.4	0.3	1.4	-0.3	0.0	0.3	-0.4	-1.2
Body Mass Index (BMI) (2010)	1.4	1.9	2.9	-1.7	1.2	-1.3	-1.5	1.2
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.3	0.1	-0.3	-0.2	0.1
Crohns Disease (2012)	0.8	1.3	2.2	1.0	-1.3	1.1	0.8	-1.5
Mean Putamen Volume	1.4	1.6	3.4	1.2	-1.2	0.9	0.9	-1.8
Fasting Glucose	2.4	2.9	4.0	-1.9	1.7	-2.0	-1.9	0.7
HbA1C	0.6	0.6	0.9	0.9	-0.9	1.0	0.7	-0.4
HDL Cholesterol	2.2	3.7	6.5	0.7	-2.4	2.5	1.4	2.0
LDL Cholesterol	0.1	0.2	0.8	-0.1	0.2	-0.9	0.2	-0.5
Lupus	0.1	0.2	0.6	0.1	-0.4	0.0	0.3	-0.8
Neuroticism (2016)	0.5	0.7	1.8	-1.0	0.6	-0.4	-1.3	-0.5
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.8	-0.6	0.4	0.9	-0.4
Rheumatoid Arthritis	3.7	5.1	6.9	2.6	-2.2	2.3	2.6	-1.4
Schizophrenia (2014)	1.2	2.7	6.3	-0.7	1.6	-1.1	-1.8	-2.5
Triglycerides	4.3	7.1	11.5	-2.5	3.2	-3.4	-2.7	0.2
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.7	-0.5	1.2	-1.1	-1.1	-1.9
Ulcerative Colitis	0.1	0.2	0.4	-0.4	0.2	-0.1	-0.6	-0.6
Blood Eosinophil Count	0.0	0.3	0.8	0.2	0.6	-0.9	0.7	-0.1
Blood Platelet Count	0.1	1.3	5.2	0.2	-0.8	0.3	0.6	2.3
Blood Red Count	0.5	5.0	17.9	-1.0	1.5	-1.4	-1.3	-4.2
Blood White Count	0.9	6.5	13.1	-1.8	3.6	-3.4	-2.1	0.1
Heel T-Score	0.0	0.1	0.2	-0.1	-0.1	-0.3	0.1	-0.5
BMI	3.1	17.9	47.5	-3.6	3.5	-2.9	-2.8	6.9
Height	0.4	7.2	14.3	1.6	-2.8	3.8	2.0	-2.7
Waist Hip Ratio (WHR)	5.2	23.3	31.8	-2.8	5.6	-5.6	-3.9	-5.5
Systolic Blood Pressure	0.1	0.3	1.5	-0.0	0.1	-0.4	0.2	1.2
Smoking Status	1.5	3.7	5.9	-1.6	1.7	-2.1	-1.7	2.4
Allergy or Eczema	0.0	0.0	0.1	0.2	-0.3	0.2	0.3	-0.0
Cardiovascular Disease	0.7	2.3	4.6	-1.1	1.6	-1.5	-0.9	2.2
Hypothyroidism (self reported)	1.0	2.3	3.3	1.5	-1.6	1.8	1.8	0.3
Respiratory disease	0.2	0.4	0.7	-0.7	0.2	-0.2	-0.8	0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.0	-0.9	1.4	-1.2	-0.7	1.7
Lung FEV1/FVC ratio	0.2	0.8	1.4	0.9	-0.8	0.8	1.2	0.9
Lung FVC	1.6	8.3	10.4	3.2	-2.8	2.2	2.9	-3.2
Neuroticism	0.5	1.3	2.8	-1.3	1.3	-0.6	-1.7	-0.1
Chronotype (morning person)	6.1	14.2	17.0	-3.9	4.0	-4.1	-3.9	2.7
Hair Pigment	0.0	1.0	3.5	-0.7	0.7	-0.6	-0.6	1.9
Tanning	0.1	1.1	4.5	0.4	-0.6	0.5	0.5	2.1
Hand grip strength (left)	0.1	0.2	0.4	0.0	-0.4	0.6	0.3	0.4
Number of treatments/medications taken	3.6	6.5	8.6	-2.5	2.9	-2.8	-2.7	1.6
Average weekly spirits intake	1.3	1.6	6.1	-0.9	0.6	-0.4	-0.5	2.5
Sensitivity / hurt feelings	0.2	0.4	0.6	-0.6	0.7	-0.7	-0.8	0.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.2	-0.5	0.8	-0.8	-0.9	-1.5
Hearing difficulty/problems: Yes	1.5	2.2	8.6	1.2	-0.4	0.2	0.8	-2.9
Relative age of first facial hair	1.6	3.3	3.8	2.0	-1.9	1.8	1.9	-1.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.0	0.2	0.2	-0.2	0.0	-1.4
Ever used hormone-replacement therapy (HRT)	6.7	8.5	12.3	-2.9	3.4	-3.5	-3.1	0.6
Ever had hysterectomy (womb removed)	4.2	4.8	7.8	-2.0	2.7	-2.8	-2.1	0.7
Systolic blood pressure, automated reading	0.3	0.8	1.2	0.8	-0.9	0.9	1.1	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.0	0.2	0.4	-0.3	0.2	-1.0
Angina	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.1
Medication for hormone replacement therapy	1.1	1.2	2.4	-0.6	1.5	-1.6	-0.8	-0.7
Vitamin and mineral supplements	0.2	0.3	0.9	0.5	-0.4	0.5	0.3	-1.0
Supplements: Zinc	0.3	0.3	1.0	0.2	0.6	-0.5	-0.2	-1.0
Medication: Co-codamol	0.3	0.4	1.2	0.2	0.5	-0.7	-0.1	-1.1
Medication: Metformin	0.1	0.2	0.5	-0.2	0.5	-0.1	0.0	0.7
Diabetes (father)	0.9	1.2	2.0	-0.9	1.4	-1.3	-0.9	0.6
Diabetes (mother)	0.2	0.3	0.6	-0.5	0.6	-0.8	-0.5	0.1
Severe depression (siblings)	0.7	0.8	1.2	-0.7	1.0	-1.1	-0.9	-0.8
Pack years adult smoking proportion	0.4	0.7	2.6	-0.1	0.6	-0.5	-0.4	-1.6
Impedance of leg (right)	0.8	3.9	17.7	0.8	-0.9	0.4	0.3	-4.2
Leg fat-free mass (left)	0.7	3.6	10.2	-1.7	1.6	-1.0	-1.2	3.2
Trunk fat percentage	1.0	3.9	4.9	-2.2	2.1	-1.6	-1.8	2.0
Hand grip strength (right)	0.5	1.5	2.6	0.3	-1.3	1.6	0.8	1.5
Townsend deprivation index at recruitment	0.1	0.1	0.4	0.1	0.0	-0.2	0.1	-0.6
Current tobacco smoking	0.1	0.1	0.3	0.2	0.2	-0.2	0.0	-0.6
Average weekly fortified wine intake	0.3	0.4	0.7	0.3	-0.6	0.9	0.6	0.5
Maternal smoking around birth	0.4	0.6	2.4	0.7	-0.1	0.2	0.5	-1.6
Fed-up feelings	0.8	1.5	2.0	-1.4	1.4	-1.0	-1.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.4	0.5	-0.1	-0.1	0.0	-1.9
Relative age voice broke	0.2	0.4	0.7	0.7	-0.6	0.5	0.8	0.1
Taking other prescription medications	1.2	1.9	2.8	-1.2	1.7	-1.6	-1.4	-0.9
Age when periods started (menarche)	4.8	11.5	17.6	3.1	-4.2	4.1	3.7	0.6
Bilateral oophorectomy (both ovaries removed)	9.7	11.2	15.1	-3.3	3.9	-3.8	-3.5	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.1	-1.4	1.0	-1.4	-1.1	0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	0.6	-0.7	0.7	0.2	-1.3
Qualifications: CSEs or equivalent	0.2	0.2	0.7	-0.0	-0.3	0.5	0.0	0.9
Serious illness, injury or assault to yourself	1.9	2.3	3.9	-1.1	1.8	-2.0	-1.5	-1.0
High blood pressure	0.3	0.8	1.6	0.7	-0.7	0.8	0.9	1.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.1	0.3	-0.4	-0.3	-0.4
Multivitamins +/- minerals	0.1	0.1	0.5	0.1	-0.0	-0.1	0.5	0.7
Stomach or abdominal pain in last month	1.2	1.4	1.9	-0.8	1.4	-1.3	-1.1	-1.3
Supplements: Glucosamine	0.2	0.3	0.7	-0.3	0.7	-0.8	-0.5	0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	5.5	0.6	0.1	-0.4	0.4	-2.3
Medication: Atenolol	0.1	0.2	0.5	-0.5	0.2	-0.2	-0.3	0.7
Medication: Levothyroxine sodium	2.4	4.1	5.7	2.1	-2.4	2.3	2.3	-0.5
Sitting height	0.1	0.5	1.6	0.1	-0.7	1.3	0.3	-0.3
Chronic bronchitis/emphysema (father)	2.2	2.5	3.5	1.6	-1.9	1.8	1.6	-0.8
High blood pressure (mother)	2.3	3.2	4.5	-1.9	2.1	-2.1	-1.9	0.3
Body mass index (BMI)	2.2	9.4	20.0	-2.6	3.1	-2.5	-2.1	4.5
Impedance of leg (left)	1.0	5.0	22.1	1.1	-1.1	0.5	0.5	-4.7
Leg predicted mass (left)	0.7	3.8	10.5	-1.7	1.7	-1.0	-1.2	3.2
Trunk fat mass	1.1	4.5	6.3	-2.3	2.3	-1.6	-1.9	2.5
Waist circumference	2.1	7.6	13.7	-2.6	3.7	-3.2	-2.5	1.1
Number of incorrect matches in round	0.3	0.5	1.1	-0.8	-0.2	0.5	-0.6	1.0
Past tobacco smoking	0.7	1.3	4.6	0.8	-0.5	0.9	0.6	-2.1
Alcohol usually taken with meals	0.8	1.4	2.0	-1.3	1.0	-1.4	-1.4	0.2
Nervous feelings	0.7	1.4	6.5	0.1	0.1	0.3	-0.4	-2.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	-0.7	0.7	-0.5	-1.2	-1.4
Hearing difficulty/problems with background noise	0.5	0.9	4.1	0.2	0.2	-0.3	-0.3	-2.0
Hair/balding pattern: Pattern 2	2.1	2.7	5.2	-1.7	1.3	-1.2	-1.4	2.3
Had menopause	0.5	0.6	0.8	0.8	-0.9	0.8	0.8	-0.5
Had other major operations	2.6	3.2	4.3	-1.9	2.0	-2.1	-1.8	1.0
Forced vital capacity (FVC)	0.5	2.1	5.1	1.2	-1.3	1.3	0.8	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.0	-1.4	1.3	-1.7	-1.2	0.7
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.5	-1.2	1.9	-1.7	-1.4	-0.5
Qualifications: None of the above	0.1	0.2	0.4	0.1	-0.4	0.7	0.1	0.7
Financial difficulties in last 2 years	1.0	1.4	2.6	-0.7	1.4	-1.6	-1.1	-0.8
Mouth/teeth dental problems	0.9	1.4	3.0	-1.2	0.8	-0.9	-1.1	1.7
Heart attack	0.3	0.3	0.9	-0.6	0.3	-0.3	-0.4	1.0
Allergy	0.1	0.3	0.6	0.6	-0.4	0.4	0.7	-0.0
Pain all over the body in last month	0.2	0.2	0.4	-0.5	0.4	-0.2	-0.4	-0.7
Diabetes (self-reported)	0.2	0.3	0.9	0.7	-0.3	0.5	0.9	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.0	-0.2	0.3	-0.1	-0.7
Medication: Ramipril	0.4	0.5	0.6	0.8	-0.8	0.5	0.7	-0.5
Medication: Simvastatin	1.2	1.8	4.5	-1.3	1.0	-0.6	-1.2	2.1
Fluid intelligence score	0.3	0.6	2.6	0.2	0.1	-0.2	0.4	1.6
Illnesses of siblings	0.1	0.1	0.3	-0.2	0.5	-0.3	-0.1	0.5
Neuroticism score	0.7	1.5	2.9	-1.4	1.4	-0.9	-1.7	-0.1
Weight	1.0	5.1	10.8	-2.1	2.3	-1.6	-1.6	3.3
Impedance of arm (right)	1.0	4.6	15.8	1.1	-1.8	1.4	0.8	-4.0
Arm fat percentage (right)	2.1	8.2	12.9	-2.8	2.9	-2.5	-2.4	3.6
Trunk fat-free mass	0.1	0.6	2.5	-0.4	0.6	-0.0	-0.2	1.6
Hip circumference	0.7	3.0	12.5	-1.1	1.0	-0.4	-0.5	3.5
Time employed in main current job	2.4	2.8	3.8	-1.6	1.9	-1.9	-1.7	1.2
Alcohol intake versus 10 years previously	1.5	2.3	3.2	1.6	-1.8	1.6	1.7	-0.1
Father’s age at death	1.1	1.5	2.1	1.2	-1.1	1.2	1.2	-1.5
Worrier / anxious feelings	0.8	1.6	5.8	-0.4	0.8	-0.6	-1.0	-2.4
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	3.3	-1.4	1.8	-1.7	-1.8	-1.0
Falls in the last year	0.5	0.7	1.2	-0.4	1.0	-1.1	-0.8	-0.5
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.3	0.1
Number of live births	0.1	0.1	0.2	-0.1	0.2	-0.3	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.1	1.1	-1.2	1.1	0.9	-1.8
Pulse rate	1.1	1.9	2.8	-0.7	1.7	-1.4	-1.3	-1.6
Happiness	0.1	0.2	0.5	-0.4	-0.3	0.7	-0.3	-0.1
Noisy workplace	1.3	1.7	2.3	1.3	-1.4	1.5	1.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	-0.2	-0.2	-0.1	-0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	-0.3	0.9	-0.8	-0.7	-1.0
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.5	-0.3	0.4	0.4	-0.2
Asthma	0.8	1.6	2.1	-1.3	1.4	-1.4	-1.4	0.7
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.1	6.6	-2.6	1.9	-2.0	-2.5	2.2
Medication: Cholesterol lowering	0.5	0.8	3.3	-0.7	0.2	-0.1	-0.4	1.8
Depression (self-reported)	0.8	0.9	1.5	-0.8	0.9	-0.8	-1.2	-1.0
Medication: Lansoprazole	3.2	3.6	5.2	-1.9	2.3	-2.3	-2.0	0.1
Prospective memory result	0.4	0.5	2.4	-0.2	0.1	0.2	-0.5	-1.5
Lung cancer (father)	0.0	0.0	0.1	-0.0	-0.1	0.2	0.0	0.3
Illnesses of mother	0.5	0.6	0.9	0.9	-0.9	0.7	0.9	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.7	0.9	-0.7	0.8	0.7	-1.6
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.7	0.1	0.1	0.6	-0.2
Impedance of arm (left)	0.9	4.2	13.9	1.0	-1.9	1.5	0.7	-3.7
Arm fat mass (right)	1.7	7.0	11.6	-2.5	2.8	-2.2	-2.1	3.4
Trunk predicted mass	0.1	0.5	2.3	-0.4	0.5	0.1	-0.1	1.5
Standing height	0.2	2.0	5.2	0.6	-1.2	1.6	0.7	-2.3
Length of working week for main job	1.2	1.4	2.8	-1.1	1.1	-0.8	-1.0	1.7
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.1	-0.2	0.4	0.2	1.1
Breastfed as a baby	6.1	7.6	10.9	2.7	-3.3	3.3	3.0	-0.5
Tense / ‘highly strung’	0.3	0.6	1.1	-0.5	0.8	-0.2	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.1	-1.3	1.4	-1.1	-1.4	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.4	-0.2	0.0	0.1	-0.0	1.2
Birth weight of first child	0.0	0.0	0.1	-0.0	-0.3	0.1	0.0	0.0
Peak expiratory flow (PEF)	0.2	0.5	1.0	0.6	-0.8	1.0	0.5	-0.3
Pulse wave reflection index	1.1	1.4	4.2	-0.7	1.1	-0.7	-0.7	2.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.2	0.9	-0.9	-0.4	0.5
Loud music exposure frequency	1.7	1.9	2.4	1.4	-1.5	1.5	1.3	-1.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.2
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	6.3	1.5	-0.8	0.8	1.2	-2.5
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.5	0.6	-0.4	-0.5	-0.9
Medication: Paracetamol	1.9	3.1	5.8	-1.4	2.4	-2.0	-1.8	-0.8
Headache pain in last month	1.6	2.7	4.0	-1.9	1.9	-1.6	-2.0	-0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.1	0.6	-0.4	0.2	0.2	-1.8
Glaucoma (self-reported)	0.8	0.9	2.6	-0.3	0.8	-0.8	-0.8	-1.6
Gout (self-reported)	0.6	0.8	3.8	0.3	-0.0	0.2	0.2	-1.9
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.8	1.3	-1.6	1.7	1.5	0.3
Medication: Amlodipine	0.1	0.2	0.4	0.5	-0.0	0.1	0.5	-0.6
Medication: Ventolin 100micrograms inhaler	2.6	3.3	4.3	-1.7	1.9	-2.1	-2.0	1.2
Birth weight	0.4	0.8	1.1	0.8	-1.1	1.0	0.9	-0.7
Chronic bronchitis/emphysema (mother)	1.4	1.7	2.6	1.2	-1.2	1.3	1.0	-1.6
High blood pressure (siblings)	0.1	0.2	0.7	0.4	-0.1	-0.0	0.1	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.7	5.1	1.0	-0.9	1.0	0.7	-2.3
Body fat percentage	1.5	6.1	7.4	-2.6	2.6	-2.2	-2.2	2.7
Leg fat percentage (right)	2.4	8.6	11.9	-2.8	3.1	-2.7	-2.4	3.5
Arm fat-free mass (right)	0.4	1.8	5.5	-1.1	1.3	-0.6	-0.7	2.4
Exposure to tobacco smoke outside home	0.3	0.3	0.6	-0.6	0.5	-0.3	-0.8	0.6
Comparative body size at age 10	1.2	3.3	4.5	-1.4	2.0	-2.1	-1.4	2.0
Number of full brothers	1.4	1.8	2.6	-1.4	1.1	-1.2	-1.3	1.6
Worry too long after embarrassment	1.9	3.2	4.8	-1.4	2.1	-2.2	-2.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	2.4	-1.3	1.5	-1.4	-1.5	-0.8
Wheeze or whistling in the chest in last year	1.1	2.0	3.1	-1.5	1.7	-1.3	-1.8	-0.3
Number of children fathered	2.7	3.1	3.4	-1.7	1.9	-1.8	-1.5	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.6	0.3	-0.2	-0.5	0.6
Age at first live birth	1.9	3.3	4.9	1.9	-2.0	1.9	2.2	-0.8
Pulse wave peak to peak time	0.1	0.1	0.4	-0.6	-0.1	0.0	-0.5	0.1
Health satisfaction	0.6	0.8	1.8	-0.5	1.3	-0.9	-0.9	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.5	-0.5	0.4	-0.1	-0.7	0.2
Qualifications: College or University degree	0.3	0.9	1.9	-0.3	1.0	-1.0	-0.6	-1.4
Eye problems/disorders: None of the above	1.4	1.6	2.3	1.4	-1.5	1.3	1.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.0	0.1	0.2	-0.3	-0.3
Emphysema/chronic bronchitis	4.8	5.4	7.1	2.3	-2.7	2.5	2.1	-1.9
Medication for pain relief, constipation, heartburn	3.8	6.6	9.3	2.6	-2.9	2.8	3.0	-0.6
Neck or shoulder pain in last month	0.4	0.5	2.1	0.2	0.6	-0.4	-0.1	-1.5
Medication: Blood pressure	0.3	0.6	1.9	0.3	-0.4	0.6	0.6	1.4
Angina (self-reported)	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3	0.0
Migraine (self-reported)	2.7	3.4	4.2	1.9	-1.6	2.0	2.0	-1.6
Medication: Ibuprofen	4.2	5.0	6.1	-2.5	1.9	-1.9	-2.4	2.4
Medication: Allopurinol	0.2	0.3	1.5	0.1	0.2	-0.1	-0.1	-1.2
Medication: Omeprazole	3.3	3.9	6.5	-1.7	2.4	-2.6	-2.0	-0.7
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.1	0.4	-0.2	-0.1	0.1
Mean time to correctly identify matches	0.9	1.6	2.8	1.0	-1.7	1.7	1.2	-0.1
Heart disease (mother)	2.0	2.5	2.7	-1.5	1.6	-1.6	-1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	-0.1	-0.4	0.2	0.0	0.9
Whole body fat mass	1.4	5.7	7.9	-2.4	2.6	-2.0	-2.0	2.8
Leg fat mass (right)	2.4	9.3	14.3	-2.9	3.2	-2.6	-2.5	3.8
Arm predicted mass (right)	0.2	1.2	4.2	-0.8	1.0	-0.4	-0.4	2.1
Pulse rate, automated reading	1.0	3.3	8.2	-0.3	2.0	-1.8	-1.1	-2.9
Alcohol intake frequency.	0.1	0.3	1.0	0.0	0.7	-0.3	-0.3	-1.0
Comparative height size at age 10	0.2	1.0	2.2	-0.7	0.8	-0.5	-1.0	-1.5
Number of full sisters	0.1	0.2	0.2	0.5	-0.4	0.4	0.4	-0.1
Suffer from ‘nerves’	0.2	0.3	1.1	-0.1	-0.2	0.6	-0.4	-1.0
Overall health rating	0.9	1.9	3.1	-0.6	1.7	-1.4	-1.2	-1.7
Chest pain or discomfort	0.9	1.3	2.6	1.2	-0.8	1.0	0.8	-1.6
Had major operations	4.4	5.2	6.9	2.6	-2.1	2.0	2.5	-2.0
Age at last live birth	1.6	2.3	3.1	1.5	-1.6	1.5	1.8	-1.3
Family relationship satisfaction	0.4	0.5	1.6	0.4	-0.5	0.5	0.2	-1.3
Leg pain on walking	0.4	0.6	0.9	0.9	-0.4	0.6	0.9	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.1	0.2	-0.3	0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	-0.2	-0.2	0.3	-0.3	1.1
Illness, injury, bereavement, stress in last 2 years	2.9	3.5	5.5	1.6	-2.4	2.2	1.9	0.7
Medication: Aspirin	1.2	1.6	2.5	-1.4	1.0	-0.9	-1.3	1.6
Supplements: Vitamin C	0.1	0.1	0.4	0.1	-0.3	0.2	0.0	-0.7
Knee pain experienced in last month	1.1	1.7	2.2	-1.3	1.5	-1.4	-1.2	1.1
Hypertension (Self-reported)	0.2	0.7	1.3	0.6	-0.7	0.8	0.8	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.4	0.7	-0.6	-0.5	0.0
Illnesses of father: Heart disease	0.0	0.0	0.1	0.1	-0.2	0.1	0.1	0.2
Illnesses of siblings: Diabetes	1.9	2.4	3.7	1.8	-1.3	1.4	1.9	-1.1
Smoking status: Previous	1.4	2.1	4.4	-1.4	1.1	-1.3	-1.2	2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.6	1.0	-1.0	1.3	0.8	-1.0
Whole body fat-free mass	0.2	1.4	4.6	-0.9	1.0	-0.4	-0.5	2.1
Leg fat-free mass (right)	0.6	3.0	8.3	-1.5	1.6	-1.0	-1.1	2.9
Arm fat percentage (left)	1.9	7.8	12.6	-2.7	2.8	-2.3	-2.3	3.6
Average weekly red wine intake	4.8	7.0	11.3	-2.6	2.4	-2.2	-2.5	3.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	0.2	-0.1	-0.3	-0.4
Mood swings	0.2	0.3	0.5	-0.7	0.5	0.0	-0.6	0.5
Loneliness, isolation	0.4	0.5	0.9	-0.9	0.5	-0.3	-1.0	0.7
Long-standing illness, disability or infirmity	3.0	4.6	7.6	-1.9	2.6	-2.8	-2.2	0.1
Ever had bowel cancer screening	0.1	0.2	0.3	-0.5	0.2	-0.2	-0.6	-0.4
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.4	0.1	0.1	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-0.6	1.1	-0.9	-0.6	0.0
Friendships satisfaction	0.8	1.0	2.2	0.9	-1.1	1.5	0.8	-0.3
Qualifications: nursing, teaching	1.3	2.0	3.1	-1.4	1.4	-1.8	-1.2	1.1
Commuting to job workplace: Walk	1.5	1.6	4.3	1.3	-0.6	0.5	1.2	-2.1
Eye problems/disorders: Cataract	0.3	0.4	0.5	-0.7	0.7	-0.6	-0.7	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.3	-0.3	0.2	0.5	-0.6
Medication for cholesterol	1.6	2.5	5.3	0.8	-2.1	2.3	1.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-1.0	0.2	-0.2	-1.0	0.4
Back pain experienced in last month	0.1	0.1	0.2	0.3	0.5	-0.4	0.1	-0.2
Mineral and other dietary supplements	1.7	2.3	3.0	1.3	-1.7	1.7	1.5	-1.3
Breast cancer (self-reported)	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.3	-0.3
Asthma (self-reported)	0.8	1.6	2.3	-1.3	1.4	-1.3	-1.5	0.7
Osteoporosis (self-reported)	0.5	0.6	1.3	0.8	-0.6	0.5	0.6	-1.1
Osteoarthritis (self-reported)	1.9	2.5	4.2	-1.5	2.0	-1.7	-1.5	1.1
Medication: Aspirin	0.9	1.2	1.9	-1.2	0.8	-0.7	-1.1	1.4
Medication: Gliclazide	0.4	0.5	0.7	-0.7	0.8	-0.7	-0.5	0.6
Illnesses of father: None of the above (group 1)	1.6	1.9	2.7	-1.4	1.6	-1.5	-1.5	0.6
Smoking status: Current	0.0	0.0	0.1	0.0	0.2	-0.3	0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.8	1.0	-1.0	0.8	0.9	-1.4
Whole body water mass	0.3	1.8	5.4	-1.1	1.2	-0.6	-0.8	2.3
Leg predicted mass (right)	0.6	3.1	8.2	-1.5	1.6	-1.0	-1.1	2.9
Arm fat mass (left)	1.9	7.8	13.4	-2.7	2.9	-2.2	-2.2	3.7
Number of self-reported non-cancer illnesses	0.9	1.5	2.4	-1.1	1.4	-1.4	-1.6	0.2
Average weekly champagne plus white wine intake	0.7	0.9	1.5	0.4	-1.2	1.0	0.7	1.2
Miserableness	0.5	0.9	1.9	-1.0	0.6	-0.3	-1.0	1.4
Guilty feelings	0.6	0.9	2.7	0.7	-0.7	0.9	0.3	-1.6
Wears glasses or contact lenses	2.2	2.5	4.3	1.1	-2.1	2.0	1.4	0.9
Ever taken oral contraceptive pill	3.1	3.5	3.7	-1.9	1.9	-1.9	-1.9	1.8
Hearing aid user	0.4	0.4	0.7	-0.5	0.7	-0.7	-0.4	0.8
Mother’s age at death	5.9	7.4	10.1	2.6	-3.2	3.2	2.7	-1.7
Financial situation satisfaction	0.2	0.2	0.8	0.4	-0.3	0.3	0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.6	0.2	-0.0	0.3	0.0	-0.8
Commuting to job workplace: Public transport	1.5	1.7	2.3	-1.5	1.4	-1.5	-1.3	0.6
Eye problems/disorders: Glaucoma	0.8	1.0	3.9	0.7	-0.4	0.5	0.4	-2.0
Medication: Blood pressure	0.0	0.1	0.3	0.5	0.2	-0.3	0.2	0.1
Pain type(s) experienced in last month: Hip pain	5.0	6.3	8.5	-2.5	2.8	-2.9	-2.6	1.5
Supplements: Fish oil (including cod liver oil)	1.1	1.4	1.7	-1.1	1.2	-1.3	-1.3	1.0
High cholesterol (Self-reported)	0.3	0.5	1.8	-0.5	0.6	-0.3	-0.5	1.3
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.5	0.0	0.2	0.5	-0.0
Medication: Paracetamol	1.3	1.9	3.3	-1.3	1.8	-1.5	-1.5	-0.2
Medication: Lisinopril	0.9	1.1	2.3	-1.0	1.1	-0.9	-0.5	1.5
Medication: Atorvastatin	0.5	0.6	1.0	1.0	-0.5	0.5	1.0	-0.9
Illnesses of father: High blood pressure	6.5	8.0	10.0	3.2	-2.9	3.0	3.0	-1.9
Alcohol drinker status: Never	1.4	1.7	2.4	-1.5	1.4	-1.3	-1.5	0.5
Ever smoked	0.4	0.7	1.4	0.5	-1.0	0.5	0.7	1.2
Basal metabolic rate	0.4	2.4	6.2	-1.4	1.5	-0.9	-1.0	2.5
Leg fat percentage (left)	2.2	7.9	11.0	-2.6	3.1	-2.6	-2.2	3.3
Arm fat-free mass (left)	0.4	2.1	4.6	-1.2	1.6	-0.9	-1.0	2.1
Number of operations (self-reported)	0.6	0.8	1.3	-0.8	1.1	-1.2	-0.9	0.0
Average weekly beer plus cider intake	2.2	3.2	4.5	2.0	-1.7	2.1	2.0	-0.4
Irritability	3.0	5.1	11.9	-2.3	1.7	-1.4	-2.0	3.5
Risk taking	2.6	3.8	6.8	-1.9	2.6	-2.3	-1.9	0.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	-1.1	0.3	-0.3	-0.9	1.4
Fractured/broken bones in last 5 years	0.8	1.0	1.7	1.3	-0.7	0.9	1.2	-0.8
Age started oral contraceptive pill	0.3	0.4	0.6	0.6	-0.7	0.8	0.5	-0.4
Diastolic blood pressure, automated reading	0.3	1.0	1.9	-0.7	1.4	-1.2	-1.0	-0.5
Ever depressed for a whole week	0.6	0.8	1.9	-0.5	1.4	-1.1	-0.7	0.1
Unable to work because of sickness or disability	0.4	0.6	1.8	0.7	-0.4	0.3	0.5	-1.3
Commuting to job workplace: Cycle	3.8	4.5	5.9	2.1	-2.4	2.4	2.3	-1.2
Myopia	0.1	0.1	0.3	-0.1	-0.1	-0.3	-0.2	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.5	-0.2	0.1	-0.2	-0.3	-1.2
Cholesterol lowering medication	0.4	0.5	1.2	-0.4	1.1	-0.8	-0.8	0.3
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	5.3	-1.4	2.1	-2.3	-1.7	-0.9
Pain experienced in last month	1.3	2.1	4.0	1.2	-2.0	1.8	1.3	0.0
Supplements: Calcium	0.2	0.2	0.9	0.0	-0.1	-0.0	-0.2	-1.0
Basal cell carcinoma (self-reported)	1.9	2.2	3.0	-1.3	1.7	-1.6	-1.7	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.8	0.5	-0.5	-0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	-0.2	0.4	-0.2	-0.2	-1.0
Heart disease (siblings)	0.9	1.1	2.0	-1.2	0.9	-0.8	-1.4	0.9
Alcohol drinker status: Previous	2.0	2.3	3.0	-1.7	1.5	-1.6	-1.7	0.9
Pack years of smoking	0.2	0.3	1.6	0.1	0.3	-0.1	-0.1	-1.3
Impedance of whole body	1.1	5.5	22.2	1.1	-1.6	1.1	0.6	-4.7
Leg fat mass (left)	2.3	9.1	13.8	-2.9	3.2	-2.6	-2.4	3.7
Arm predicted mass (left)	0.4	2.0	4.7	-1.2	1.5	-0.9	-0.9	2.2