TWAS hub - TXNDC3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0264	0.0102	0.00360	-0.001	0.010	0.003	0.011	0.001	0.6100	0.00020	0.02800	9.3e-05	0.1600
2	TCGA	Esophageal Carcinoma	0.4790	0.1440	0.00290	-0.005	0.113	0.061	NA	0.080	0.5100	0.00019	0.00550	NA	0.0017
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0685	0.0296	0.00430	0.015	0.026	0.024	NA	0.022	0.0066	0.00051	0.00087	NA	0.0014
4	TCGA	Brain Lower Grade Glioma	0.0730	0.0271	0.00053	-0.001	0.013	0.005	NA	0.002	0.3800	0.01100	0.07400	NA	0.1800
5	TCGA	Lung Adenocarcinoma	0.0396	0.0218	0.00840	-0.001	0.019	0.006	NA	0.004	0.4000	0.00240	0.05100	NA	0.1000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Heel T-Score	5.7	45.5	71.7	7.0	-8.5	-5.8	5.6	-6.5
Major Depression (MDD)	4.2	5.1	7.6	2.6	2.8	2.3	2.1	1.1
Heel bone mineral density (BMD) T-score, automated (left)	3.9	8.8	17.0	1.0	-3.7	-3.2	1.5	-4.1
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	14.1	1.3	-3.5	-3.0	2.3	-3.8
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	6.7	2.6	0.3	2.2	1.5	2.6
Heart disease (siblings)	3.0	3.6	10.4	-1.2	-2.1	-3.2	-1.0	-0.9
Loud music exposure frequency	2.8	3.1	8.9	1.3	3.0	1.4	0.9	1.4
Supplements: Calcium	2.7	3.0	7.2	1.9	1.7	0.9	0.8	2.7
Worry too long after embarrassment	2.4	4.1	6.7	-2.6	-2.3	-0.9	-2.0	-2.0
Osteoporosis (self-reported)	2.1	2.6	9.2	-1.2	3.0	1.6	0.2	-0.1
Alzheimer’s Disease (including proxy)	2.0	2.8	7.2	2.7	0.6	-0.9	0.8	2.3
Illnesses of mother	2.0	2.5	7.3	-0.6	-2.7	-2.0	0.0	-0.7
Alzheimer’s Disease (in mother)	1.9	2.2	5.7	2.4	-0.5	-0.4	1.7	1.4
Systolic Blood Pressure	1.9	9.5	21.5	3.0	2.2	2.6	4.6	2.4
Chronic bronchitis/emphysema (father)	1.9	2.2	6.4	1.9	0.8	0.4	2.5	0.5
Medication: Ventolin 100micrograms inhaler	1.9	2.4	5.0	-0.5	0.2	-2.2	-1.7	-2.0
Osteoarthritis (self-reported)	1.8	2.3	9.0	-0.7	-1.2	-0.5	3.0	0.7
Illnesses of father: None of the above (group 1)	1.8	2.3	3.2	-1.4	0.8	1.8	-1.7	-1.6
Ulcerative Colitis	1.7	2.4	6.0	-0.7	0.6	-1.3	1.9	-2.5
Diabetes (father)	1.7	2.1	10.2	-0.1	-0.0	0.6	-0.1	3.2
Alzheimer’s Disease (in father)	1.5	1.6	3.5	1.6	1.9	-0.7	-0.6	-1.1
Average weekly spirits intake	1.5	1.8	4.8	-1.5	-2.2	-1.1	0.7	-0.6
Eye problems/disorders: None of the above	1.5	1.7	3.5	0.5	1.6	1.0	1.9	1.2
Ever had bowel cancer screening	1.5	1.8	5.0	-2.2	1.9	-0.3	0.3	0.0
Medication: Gliclazide	1.5	1.7	5.7	1.0	-0.7	-2.4	-0.6	-1.1
Medication: Blood pressure	1.5	2.9	5.4	0.4	1.8	1.6	1.7	2.3
Relative age of first facial hair	1.4	2.8	6.2	1.3	2.2	1.1	2.5	-0.2
Relative age voice broke	1.4	2.2	4.0	1.0	2.0	1.5	1.9	0.1
Medication: Ibuprofen	1.4	1.6	2.8	-1.2	0.0	1.7	1.3	1.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.3	-1.4	-2.3	-0.4	-1.0	-0.3
Alcohol intake versus 10 years previously	1.3	1.9	4.6	-0.1	-0.9	1.0	1.8	2.1
Knee pain experienced in last month	1.3	2.0	4.7	-2.2	0.8	0.2	1.9	1.0
Hypertension (Self-reported)	1.3	3.6	6.0	1.4	1.4	2.4	1.6	2.4
Age at First Birth	1.2	1.7	3.1	-1.6	-1.8	-0.6	-1.6	0.1
Rheumatoid Arthritis	1.2	1.6	3.6	-0.7	0.5	-1.9	-0.8	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.8	1.0	0.4	0.7	1.3	1.7
Had menopause	1.2	1.5	2.5	-1.4	1.5	0.8	0.5	1.6
Impedance of arm (right)	1.2	5.5	14.4	0.5	3.4	0.4	3.8	-1.0
Falls in the last year	1.2	1.6	4.0	-2.0	0.9	0.6	-1.6	-0.0
Illnesses of father: Heart disease	1.2	1.7	3.6	-1.2	-0.7	-1.8	-0.2	1.9
Diastolic blood pressure, automated reading	1.2	3.7	11.0	1.3	0.8	1.8	1.3	3.3
Commuting to job workplace: Cycle	1.2	1.4	5.5	1.1	-0.3	-0.4	2.3	0.1
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.6	0.9	-0.2	-0.7	0.7	2.4
Ovarian Cancer	1.1	1.5	4.4	-0.2	2.1	1.5	-0.8	0.1
Prostate Cancer	1.1	1.6	6.5	0.5	2.5	-0.1	0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.9	1.4	1.3	0.4	0.3	1.7
Current tobacco smoking	1.1	1.8	4.2	2.0	0.0	0.1	0.9	2.0
High blood pressure	1.1	3.1	6.2	1.2	1.3	1.9	1.6	2.5
Multivitamins +/- minerals	1.1	1.4	5.4	1.2	0.3	0.2	2.3	0.1
Pulse wave reflection index	1.1	1.4	3.8	0.9	0.5	1.1	0.9	1.9
Blood clot in the leg (DVT)	1.1	1.5	5.7	0.8	-0.1	-0.7	0.7	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.4	-1.2	-0.3	-1.6	-1.5	-0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	4.6	2.1	0.1	1.0	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	5.5	-0.0	0.5	2.3	2.3	-0.4
Medication for cholesterol	1.1	1.6	3.1	-0.7	-1.6	-1.3	-0.4	-1.8
Smoking status: Current	1.1	1.7	4.0	2.0	-0.1	0.3	0.8	2.0
Medication: Atorvastatin	1.1	1.4	2.6	1.0	0.8	-0.2	1.6	1.5
Mean Putamen Volume	1.0	1.1	2.0	-0.9	0.4	1.4	1.0	1.3
Fasting Glucose	1.0	1.2	2.5	-1.4	-1.1	-0.4	-1.6	0.0
Average weekly fortified wine intake	1.0	1.2	3.3	-1.4	-0.8	-1.8	-0.3	-0.4
Age when periods started (menarche)	1.0	2.5	9.6	1.1	0.2	-1.0	-0.7	-3.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.5	0.4	1.1	0.9	1.9	0.3
High blood pressure (mother)	1.0	1.5	4.9	-0.0	2.2	1.4	0.3	0.7
Time employed in main current job	1.0	1.2	2.2	-1.1	1.5	-0.0	1.2	1.0
Medication: Omeprazole	1.0	1.2	3.7	-1.4	-1.9	-0.2	-0.5	0.0
Had major operations	1.0	1.2	4.1	0.9	0.5	0.7	0.5	2.0
Wears glasses or contact lenses	1.0	1.1	4.3	2.1	0.6	0.2	-0.1	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.2	2.7	1.3	-1.2	-0.4	1.7	0.1
Pack years of smoking	1.0	1.5	3.1	-1.0	0.8	-0.4	-1.6	-1.8
HbA1C	0.9	0.9	2.0	1.1	-1.2	-1.4	-0.4	0.2
Hearing difficulty/problems: Yes	0.9	1.4	4.1	0.3	-0.5	-0.6	-2.0	-1.5
Medication: Simvastatin	0.9	1.4	3.4	-1.8	0.3	-0.5	-0.5	-1.7
Medication: Lansoprazole	0.9	1.0	3.6	-0.1	-0.2	-1.0	-0.5	-1.9
Lung cancer (father)	0.9	1.0	2.8	-0.2	0.9	1.7	1.2	-0.3
Impedance of arm (left)	0.9	4.0	9.4	0.6	3.0	0.3	3.1	-1.1
Breastfed as a baby	0.9	1.1	3.6	1.9	-0.1	1.1	-0.9	0.1
Peak expiratory flow (PEF)	0.9	2.0	6.5	-0.7	-1.1	-1.4	0.1	-2.5
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.6	-0.3	-1.2	-1.6	-0.4	-1.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.1	-0.1	1.3	1.8	-1.3	0.6
Gout (self-reported)	0.9	1.3	4.7	0.5	1.1	2.2	0.2	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.4	0.4	-1.1	-1.2	-1.6	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.0	-0.1	-0.9	-0.7	1.4	1.3
Average weekly red wine intake	0.9	1.3	3.8	0.5	0.4	-1.4	0.6	-2.0
Eye problems/disorders: Glaucoma	0.9	1.0	2.7	0.2	1.6	1.2	-0.9	-0.2
Fractured/broken bones in last 5 years	0.9	1.1	3.1	-1.8	0.2	-1.5	-0.6	-0.0
Ulcerative Colitis (UC)	0.8	1.4	3.7	-0.0	0.5	-1.4	1.9	-1.1
Bipolar Disorder (2011)	0.8	0.8	1.7	-0.7	-0.2	-0.8	-1.0	-1.3
Coronary Artery Disease (CAD)	0.8	0.9	1.6	-0.2	-1.1	0.1	1.2	1.3
Triglycerides	0.8	1.3	3.6	1.9	1.4	0.6	0.3	0.8
Supplements: Zinc	0.8	0.8	2.6	1.6	-0.1	-0.3	-0.1	1.2
Pack years adult smoking proportion	0.8	1.2	2.9	-0.8	1.1	-0.1	-1.1	-1.7
Qualifications: CSEs or equivalent	0.8	1.1	2.8	1.7	0.1	-0.8	1.4	-0.5
Stomach or abdominal pain in last month	0.8	1.0	2.7	0.5	1.0	-0.1	1.6	1.1
Medication: Atenolol	0.8	1.0	2.9	0.4	-0.0	1.5	0.1	1.7
Sitting height	0.8	5.7	18.0	1.0	-2.9	0.4	4.2	1.0
Pain all over the body in last month	0.8	0.8	2.2	1.5	-0.2	-0.2	-0.7	-1.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.6	-1.0	-1.3	-1.1	-0.6	1.0
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.4	-0.3	-0.5	1.9	-0.9	2.1
Prospective memory result	0.8	1.0	2.4	-0.2	0.1	0.6	1.4	1.6
Medication: Amlodipine	0.8	1.1	3.0	-0.0	1.1	0.2	1.7	1.2
High blood pressure (siblings)	0.8	1.1	2.5	0.0	1.6	0.7	1.5	-0.6
Number of full brothers	0.8	1.0	3.0	1.7	1.3	0.1	0.2	0.5
Medication: Allopurinol	0.8	1.0	2.4	1.3	-0.3	1.6	-0.4	-0.8
Age at last live birth	0.8	1.1	2.3	1.1	-0.4	0.4	-1.3	-1.5
Breast cancer (self-reported)	0.8	0.9	1.7	0.4	1.1	1.3	1.0	0.9
Cardiovascular Disease	0.7	2.2	4.2	1.1	0.8	1.9	2.0	1.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	0.2	1.0	-0.2	1.2	-1.2
Medication: Co-codamol	0.7	0.9	1.9	-0.8	-0.6	-1.1	1.4	0.4
Severe depression (siblings)	0.7	0.7	1.9	-0.6	-0.6	-1.1	0.0	-1.4
Body mass index (BMI)	0.7	3.0	5.8	-1.3	-2.4	-0.6	-2.3	1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	3.9	2.0	-0.3	0.4	0.3	-0.1
Financial difficulties in last 2 years	0.7	1.0	3.7	-0.8	-0.1	-0.4	-1.9	-0.7
Heart attack	0.7	0.9	2.1	0.7	-0.8	-1.1	-1.4	0.1
Hair/balding pattern: Pattern 3	0.7	1.0	2.3	0.7	-1.5	-0.4	-0.9	1.1
Number of live births	0.7	0.9	2.8	-0.2	-0.9	-1.1	-1.7	-0.1
Pulse rate	0.7	1.1	2.0	1.1	0.1	0.6	-1.4	-1.4
Happiness	0.7	0.8	2.0	0.8	1.4	0.6	0.7	0.9
Standing height	0.7	7.4	24.3	1.6	0.1	2.9	4.9	1.4
Birth weight of first child	0.7	1.3	2.3	0.4	1.4	0.0	1.3	1.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	-0.7	1.2	-0.4	1.1	-1.0
Headache pain in last month	0.7	1.2	5.0	-2.2	-0.9	-0.4	-0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	5.6	0.8	0.5	-0.3	0.4	2.4
Exposure to tobacco smoke outside home	0.7	0.9	1.5	-0.0	1.1	0.5	-1.2	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.2	3.7	1.9	1.0	0.7	0.7	-0.4
Migraine (self-reported)	0.7	0.9	2.5	-1.6	-0.6	-0.2	-1.2	0.3
Number of full sisters	0.7	0.8	3.0	-0.3	-1.7	-0.8	-0.2	-0.4
Supplements: Vitamin C	0.7	0.9	1.8	0.7	0.0	-0.6	1.3	-1.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.1	-1.3	1.5	-0.0	0.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	0.9	-1.1	0.1	-1.1	0.4
Friendships satisfaction	0.7	0.9	1.6	-0.7	0.7	0.7	1.0	1.3
Commuting to job workplace: Walk	0.7	0.8	3.0	-1.7	0.1	0.6	-0.8	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.9	0.2	0.7	-0.5	0.7	-1.7
Mother’s age at death	0.7	0.9	1.6	-1.1	0.1	-1.0	1.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	-0.5	-0.8	-1.5	0.5	-1.0
Leg fat percentage (left)	0.7	2.4	5.2	-1.7	-1.8	-0.5	-2.3	0.6
Average weekly beer plus cider intake	0.7	1.0	2.8	1.1	-1.7	0.3	-0.2	1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	-1.1	0.3	0.6	1.1	1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.8	1.7	0.9	-0.9	-1.0	-1.3	0.0
Impedance of whole body	0.7	3.3	7.4	0.7	2.7	-0.1	2.4	-1.7
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	-1.3	-0.1	1.0	-1.0	-0.5
Body Mass Index (BMI) (2010)	0.6	0.9	2.7	-0.2	-0.4	0.2	-1.6	1.2
Respiratory disease	0.6	1.3	3.9	1.0	-1.1	-2.0	0.1	-0.7
Systolic blood pressure, automated reading	0.6	1.7	3.9	0.8	0.6	1.3	1.5	2.0
Angina	0.6	0.8	2.1	0.1	-0.4	-0.8	-0.9	-1.5
Medication for hormone replacement therapy	0.6	0.6	1.4	1.1	0.4	0.4	0.2	1.2
Vitamin and mineral supplements	0.6	0.8	2.2	-0.7	-0.1	0.5	-1.5	1.0
Medication: Metformin	0.6	0.8	2.3	-1.1	-0.1	-1.5	-0.7	0.2
Impedance of leg (right)	0.6	3.1	6.6	1.1	2.6	-0.3	2.0	-1.9
Medication: Levothyroxine sodium	0.6	0.9	1.5	1.2	0.7	-0.2	-1.1	1.2
Impedance of leg (left)	0.6	3.0	7.7	0.5	2.8	-0.1	1.5	-2.2
Fluid intelligence score	0.6	1.2	3.4	-1.8	-0.3	-0.4	-1.2	-1.0
Trunk fat-free mass	0.6	3.7	6.4	0.6	-1.8	1.9	2.2	2.5
Medication: Cholesterol lowering	0.6	0.9	1.6	-1.2	-0.5	-0.9	-0.2	-1.2
Depression (self-reported)	0.6	0.7	1.9	-0.2	1.4	0.7	0.8	0.7
Trunk predicted mass	0.6	3.6	6.4	0.6	-1.8	1.8	2.2	2.5
Glaucoma (self-reported)	0.6	0.7	1.4	-1.1	-0.1	-0.3	-1.2	-1.1
Age at first live birth	0.6	1.1	3.3	1.8	0.1	0.3	0.9	-1.0
Chest pain or discomfort	0.6	0.8	1.7	0.7	1.3	0.9	1.1	0.1
Smoking status: Previous	0.6	0.9	1.8	-1.3	0.2	-0.4	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.5	0.1	0.6	-0.4	0.6	-2.3
Ever taken oral contraceptive pill	0.6	0.7	1.4	1.2	1.2	0.5	0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	-0.5	-0.7	0.3	-1.4	0.9
Illnesses of father: High blood pressure	0.6	0.7	1.2	-0.2	0.8	-0.6	1.1	1.1
Number of operations (self-reported)	0.6	0.8	3.7	0.5	0.3	-0.1	1.9	0.1
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.0	-0.9	-0.8	-1.2	-0.9	-2.0
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.3	-2.3	0.7	0.7	-0.8	-0.6
LDL Cholesterol	0.5	0.7	1.8	1.0	1.3	0.8	0.4	0.3
Schizophrenia (2014)	0.5	1.1	4.1	0.6	0.8	0.3	-0.6	-2.0
BMI	0.5	2.8	7.1	-1.2	-2.7	-0.5	-1.7	1.5
Waist Hip Ratio (WHR)	0.5	2.3	8.6	1.3	2.9	0.8	-0.0	-0.8
Hypothyroidism (self reported)	0.5	1.1	4.5	-0.0	1.0	-0.4	0.2	2.1
Leg fat-free mass (left)	0.5	2.4	5.3	-0.4	-2.3	1.1	0.9	2.2
Maternal smoking around birth	0.5	0.8	2.8	-0.4	-1.7	-1.0	-0.3	-0.2
Leg predicted mass (left)	0.5	2.5	5.6	-0.4	-2.4	1.0	1.0	2.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.3	0.8	1.1	0.6	0.8	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	0.3	0.6	0.7	-0.9	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	-1.0	-0.2	0.9	0.4	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.7	-1.3	-0.3	-0.5	-0.8	-0.5
Leg fat percentage (right)	0.5	2.0	4.1	-1.4	-1.8	-0.5	-2.0	0.7
Number of children fathered	0.5	0.5	1.1	0.7	-1.1	0.3	-0.0	0.9
Heart disease (mother)	0.5	0.6	1.1	-0.4	-1.0	-1.1	-0.9	-0.3
Leg fat mass (right)	0.5	1.8	4.7	-1.1	-2.2	-0.0	-1.2	1.4
Suffer from ‘nerves’	0.5	0.8	1.6	1.0	1.3	0.3	1.0	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.5	-0.5	-0.4	-0.3	-1.2	-1.1
Whole body fat-free mass	0.5	3.1	6.1	0.1	-2.2	1.4	1.5	2.5
Eye problems/disorders: Cataract	0.5	0.6	1.4	0.5	-0.6	0.0	-1.0	-1.2
Whole body water mass	0.5	2.9	5.7	0.0	-2.2	1.4	1.4	2.4
Leg predicted mass (right)	0.5	2.4	4.8	-0.7	-2.2	1.2	0.9	2.1
Arm fat mass (left)	0.5	2.1	5.3	-1.1	-2.3	-0.1	-0.6	1.9
Average weekly champagne plus white wine intake	0.5	0.7	1.8	0.2	0.1	1.3	1.2	0.6
Miserableness	0.5	0.9	1.7	-1.3	-1.0	-1.3	-0.2	0.3
Commuting to job workplace: Public transport	0.5	0.6	1.0	1.0	1.0	-0.6	1.0	0.0
Basal metabolic rate	0.5	2.7	5.4	-0.0	-2.3	1.3	1.2	2.3
Arm fat-free mass (left)	0.5	2.4	6.4	0.0	-2.5	0.9	0.5	2.2
Age started oral contraceptive pill	0.5	0.6	1.5	1.1	-0.1	-1.2	0.6	-0.3
Unable to work because of sickness or disability	0.5	0.6	1.9	-0.3	0.6	-0.8	0.2	-1.4
Leg fat mass (left)	0.5	2.0	4.6	-1.4	-2.1	-0.1	-1.4	1.1
Arm predicted mass (left)	0.5	2.3	5.5	0.2	-2.3	0.8	0.6	2.3
Bipolar Disorder or Schizophrenia	0.4	0.9	2.8	0.9	-0.1	-0.3	-0.9	-1.7
Schizophrenia (2018)	0.4	0.9	2.3	1.2	-0.3	0.3	-0.8	-1.5
Irritable Bowel Disease (IBD)	0.4	1.0	1.8	0.1	1.3	-0.7	1.3	-0.9
Reaction Time	0.4	0.7	1.9	1.4	0.4	1.1	0.6	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.3	0.2	0.3	0.6	-1.1	-0.5
Lung FVC	0.4	2.2	4.2	-0.1	-0.9	-2.0	-1.4	-2.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.9	-0.3	-1.1	-0.8	-0.5	1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.8	0.2	0.3	-0.4	-0.7	-1.3
Past tobacco smoking	0.4	0.7	1.8	1.0	0.2	0.2	1.4	0.9
Weight	0.4	1.8	4.7	-0.6	-2.2	0.7	-0.2	1.9
Hip circumference	0.4	1.8	4.2	-0.6	-1.8	0.6	-0.9	2.1
Arm fat mass (right)	0.4	1.8	4.2	-1.0	-2.1	0.1	-0.5	1.9
Length of working week for main job	0.4	0.4	1.0	-1.0	-0.0	-0.1	-1.0	-0.4
Medication: Paracetamol	0.4	0.7	1.8	-1.2	0.5	0.3	-0.4	1.4
Body fat percentage	0.4	1.8	2.9	-1.7	-1.7	-1.1	-1.4	0.4
Arm fat-free mass (right)	0.4	1.9	6.8	-0.2	-2.6	0.5	0.3	1.6
Health satisfaction	0.4	0.5	1.1	-0.8	-0.3	1.1	-0.7	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	2.2	1.5	-0.5	-0.3	0.2	0.2
Angina (self-reported)	0.4	0.5	1.2	-0.1	-0.4	-0.6	-1.0	-1.1
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-0.8	0.3	-1.1	-0.4	-0.6
Mean time to correctly identify matches	0.4	0.7	2.2	0.3	0.8	1.5	0.5	0.6
Arm predicted mass (right)	0.4	2.0	6.7	0.0	-2.6	0.6	0.6	1.7
Pulse rate, automated reading	0.4	1.2	3.0	0.2	-1.7	-1.4	-0.5	-0.7
Family relationship satisfaction	0.4	0.5	2.2	0.5	-0.2	0.1	1.5	0.2
Medication: Aspirin	0.4	0.5	1.3	0.8	-1.2	-0.8	0.3	-0.2
Leg fat-free mass (right)	0.4	2.4	4.8	-0.7	-2.2	1.2	0.8	2.1
Arm fat percentage (left)	0.4	1.7	2.9	-1.6	-1.7	-0.5	-1.3	0.9
Qualifications: nursing, teaching	0.4	0.6	1.3	-1.1	-0.8	-0.2	1.1	0.2
Hearing aid user	0.4	0.5	1.2	0.3	0.1	1.1	-1.0	0.3
Financial situation satisfaction	0.4	0.5	0.9	0.2	0.7	0.8	-0.8	-1.0
Ever smoked	0.4	0.6	1.4	-0.9	-0.6	-0.1	-1.2	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	0.2	-1.1	-0.6	-1.2	0.2
Crohns Disease (2012)	0.3	0.5	1.3	-1.0	0.5	-0.3	-0.3	-1.1
Lupus	0.3	0.4	0.7	0.8	0.6	-0.7	-0.5	-0.3
Neuroticism (2016)	0.3	0.5	1.3	0.0	-1.1	-1.0	-0.1	-0.1
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.1	-0.9	-0.7	0.7	-0.3
Height	0.3	6.1	21.5	0.1	-0.9	2.2	4.6	1.9
Allergy or Eczema	0.3	0.8	2.9	0.9	-0.2	-0.3	0.1	1.7
Number of treatments/medications taken	0.3	0.5	1.4	0.6	-0.7	-0.2	0.6	1.2
Trunk fat percentage	0.3	1.2	2.4	-1.2	-1.5	-1.1	-0.8	0.8
Trunk fat mass	0.3	1.2	3.2	-0.9	-1.8	-0.2	-0.2	1.4
Waist circumference	0.3	1.0	2.2	-0.6	-0.7	0.7	-1.5	1.3
Alcohol usually taken with meals	0.3	0.4	0.9	-0.9	0.4	0.5	0.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	-0.0	-1.1	-0.7	-0.1	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.5	0.2	0.0	0.1	-1.2	-1.1
Allergy	0.3	0.7	1.9	-0.4	0.8	1.4	0.7	-0.5
Arm fat percentage (right)	0.3	1.3	2.5	-1.6	-1.5	-0.5	-0.9	1.0
Father’s age at death	0.3	0.3	0.8	0.9	0.3	0.7	-0.4	-0.4
Asthma	0.3	0.5	1.5	0.3	-0.4	-1.2	0.2	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.3	0.3	0.8	0.2	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	1.2	0.5	-0.8	0.2	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.4	-1.5	-1.0	-0.6	-0.4	0.5
Birth weight	0.3	0.7	1.4	-0.7	1.0	-0.3	1.2	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	-0.3	0.5	0.7	0.8	0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	4.0	0.8	0.3	-0.1	2.0	-0.7
Qualifications: College or University degree	0.3	0.9	1.7	-1.3	-0.1	0.8	1.0	1.1
Neck or shoulder pain in last month	0.3	0.4	0.6	-0.6	-0.5	-0.5	-0.7	-0.8
Whole body fat mass	0.3	1.5	3.9	-1.2	-2.0	-0.3	-0.8	1.1
Comparative height size at age 10	0.3	1.8	4.5	-0.8	-1.1	1.2	2.1	0.9
Leg pain on walking	0.3	0.3	1.1	-0.2	-0.3	-1.1	0.6	0.2
Mood swings	0.3	0.6	2.3	1.5	0.6	0.4	-0.1	0.1
Long-standing illness, disability or infirmity	0.3	0.4	0.9	-0.9	-0.4	-0.5	0.1	0.9
Mineral and other dietary supplements	0.3	0.4	1.1	-1.0	0.6	-0.3	-0.6	0.2
Asthma (self-reported)	0.3	0.6	1.4	0.9	-0.4	-1.2	0.4	-0.7
Medication: Aspirin	0.3	0.4	1.2	0.3	-1.1	-0.6	0.3	0.4
Medication: Paracetamol	0.3	0.4	1.1	-0.7	0.7	0.1	0.2	1.0
Medication: Lisinopril	0.3	0.4	1.5	1.2	-0.2	0.3	0.6	0.3
Risk taking	0.3	0.4	0.8	0.9	-0.4	-0.7	0.2	0.6
Myopia	0.3	0.5	0.9	-0.8	0.6	0.6	-0.0	0.9
Cholesterol lowering medication	0.3	0.4	1.1	0.1	0.4	-1.1	0.7	-0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	-0.2	-0.9	0.4	0.2	-0.6
Bipolar Disorder (2018)	0.2	0.3	0.7	0.0	0.2	-0.9	-0.3	-0.8
Depression (Nagel 2018)	0.2	0.3	1.1	-0.1	0.5	-0.0	0.2	-1.1
Crohns Disease (2017)	0.2	0.5	1.2	0.8	1.1	0.5	0.5	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-1.0	-0.4	0.6	-0.8	0.6
Breast Cancer	0.2	0.4	0.8	-0.5	0.0	0.6	-0.9	0.8
HDL Cholesterol	0.2	0.4	1.3	-0.5	-1.2	-0.3	-0.2	0.4
Smoking Status	0.2	0.4	1.1	0.8	0.1	0.4	-0.2	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	0.7	0.3	0.3	1.0	-0.3
Lung FEV1/FVC ratio	0.2	0.8	1.2	-0.7	-1.1	-1.1	0.1	1.0
Neuroticism	0.2	0.5	1.4	0.0	-0.9	-0.3	-1.2	-0.4
Hand grip strength (left)	0.2	0.6	1.6	0.3	-0.6	1.3	-0.8	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.6	0.4	0.0	-0.5	0.7
Fed-up feelings	0.2	0.4	0.9	-0.2	-0.8	-1.0	-0.6	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.7	-0.3	-0.2	-0.4	0.8	0.5
Had other major operations	0.2	0.2	0.7	0.3	0.2	0.2	0.3	-0.8
Forced vital capacity (FVC)	0.2	0.8	2.1	0.1	0.0	-0.0	1.4	-1.3
Mouth/teeth dental problems	0.2	0.3	0.8	0.0	-0.9	-0.5	-0.6	0.1
Illnesses of siblings	0.2	0.3	0.5	0.6	-0.7	0.3	-0.7	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.4	-0.2	-0.2	-0.2	1.1	-1.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.4	-0.2	0.8	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.3	0.2	-0.3	-0.3	1.5	-0.5
Tense / ‘highly strung’	0.2	0.3	1.3	-0.1	-0.5	-0.1	-0.2	-1.1
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.9	0.8	-0.0	-0.6	-0.0
Pulse wave peak to peak time	0.2	0.2	0.4	0.4	-0.3	-0.4	0.3	-0.7
Emphysema/chronic bronchitis	0.2	0.2	0.9	-1.0	-0.2	-0.0	0.1	-0.4
Medication: Blood pressure	0.2	0.3	0.7	-0.4	0.8	0.5	0.1	0.8
Alcohol intake frequency.	0.2	0.5	0.8	-0.6	-0.0	0.7	0.9	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.3	0.2	0.8	0.8	0.4
Back pain experienced in last month	0.2	0.3	0.9	0.6	-0.3	-0.2	0.9	-0.1
Guilty feelings	0.2	0.3	0.9	0.1	-0.1	0.9	-0.4	0.4
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.2	0.3	-0.4	1.1	-0.3
Irritability	0.2	0.4	1.5	-0.5	-0.3	-1.2	0.3	0.1
Alcohol drinker status: Previous	0.2	0.2	0.7	0.3	-0.1	0.8	0.5	0.2
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.3	-0.7	-0.0	-0.8	-0.6
Worry (Nagel 2018)	0.1	0.2	0.4	0.6	0.4	0.4	-0.1	-0.6
Blood Eosinophil Count	0.1	0.5	1.5	-0.7	-0.4	0.2	-1.2	0.8
Blood Platelet Count	0.1	1.1	1.7	-0.0	0.8	1.3	1.2	1.2
Blood White Count	0.1	0.5	1.6	-0.6	-0.4	0.6	-1.3	0.2
Hair Pigment	0.1	3.4	6.9	-2.4	-0.1	-0.8	-2.6	-1.9
Tanning	0.1	0.9	1.8	-1.1	-0.9	1.3	-0.3	0.9
Sensitivity / hurt feelings	0.1	0.2	1.0	-0.2	-0.1	-0.3	-1.0	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.4	0.6	0.0	0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.3	0.2	-0.6	-0.4	0.0	0.5
Diabetes (mother)	0.1	0.2	0.5	0.7	0.4	0.3	0.2	-0.3
Hand grip strength (right)	0.1	0.4	1.7	0.1	-0.5	1.3	0.0	-0.2
Townsend deprivation index at recruitment	0.1	0.1	0.6	-0.2	0.8	-0.1	-0.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.0	-0.4	-0.6	0.1	-0.4
Number of incorrect matches in round	0.1	0.2	1.0	0.1	-0.4	-1.0	0.3	0.2
Nervous feelings	0.1	0.2	0.7	0.1	0.3	-0.4	0.1	-0.9
Qualifications: None of the above	0.1	0.2	0.5	-0.4	0.6	-0.1	-0.7	0.4
Diabetes (self-reported)	0.1	0.2	0.3	-0.2	0.4	-0.3	-0.6	-0.5
Medication: Ramipril	0.1	0.1	0.4	0.3	0.2	0.6	-0.1	0.4
Neuroticism score	0.1	0.2	0.6	-0.1	0.0	0.2	-0.7	-0.5
Worrier / anxious feelings	0.1	0.1	0.3	-0.3	0.5	0.1	-0.4	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.4	-0.4	0.5	-0.4	0.3
Noisy workplace	0.1	0.1	0.4	-0.6	-0.1	0.1	0.2	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	0.8	0.1	0.1	0.4	-0.0
Comparative body size at age 10	0.1	0.2	0.6	0.3	-0.2	-0.3	-0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	0.2	-0.5	0.0	-0.4
Shortness of breath walking on level ground	0.1	0.2	0.3	0.5	-0.1	0.5	0.4	0.5
Overall health rating	0.1	0.2	0.6	-0.8	-0.6	0.3	-0.1	0.2
Loneliness, isolation	0.1	0.2	0.3	-0.4	0.6	0.2	-0.1	-0.5
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.2	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.4	0.1	-0.6	0.7	-0.3
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.1	-0.1	-0.6	-0.6	-0.0
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	0.4	0.4	0.6	-0.0
Ever depressed for a whole week	0.1	0.2	0.5	0.0	-0.3	0.5	-0.1	0.7
Blood Red Count	0.0	0.2	0.4	-0.4	-0.6	-0.3	-0.2	-0.5
Chronotype (morning person)	0.0	0.1	0.2	0.4	0.3	0.0	0.1	0.0
Taking other prescription medications	0.0	0.1	0.2	-0.2	-0.4	-0.1	0.2	0.3
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	-0.0	0.1	0.0	0.0
Commuting to job workplace: Car/motor vehicle	0.0	0.1	0.2	0.0	-0.5	0.0	0.2	0.1
Pain experienced in last month	0.0	0.1	0.1	0.3	0.3	-0.2	0.0	-0.2

Hub : Genes

TXNDC3

Models

Trait associations