Hub : Genes

TYK2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.266 0.0858 7.0e-03 0.060 NA 0.065 NA 0.116 3.3e-03 NA 2.3e-03 NA 6.0e-05
2 YFS Blood 0.127 0.0221 0.0e+00 0.062 0.093 0.095 0.099 0.100 1.7e-19 6.3e-29 1.7e-29 1.6e-30 8.5e-31
3 TCGA Thyroid Carcinoma 0.110 0.0500 7.1e-05 0.008 0.048 0.023 NA 0.029 5.1e-02 1.9e-05 2.2e-03 NA 7.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 0.9 -0.4 0.4 -1.0
Bipolar Disorder or Schizophrenia 0.3 0.6 1.6 0.1 0.5 -1.2
Depressed Affect (Nagel 2018) 0.7 1.4 1.7 1.1 1.2 1.3
Depression (Nagel 2018) 0.1 0.1 0.2 0.4 -0.0 -0.2
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.6 1.6 1.1 0.4
Neuroticism (Nagel 2018) 0.0 0.1 0.2 0.4 -0.1 0.4
Schizophrenia (2018) 0.4 0.7 1.5 1.2 -0.1 -0.8
Schizophrenia vs Biploar Disorder 0.5 0.7 1.4 -0.6 0.5 -1.2
Worry (Nagel 2018) 0.1 0.1 0.3 -0.6 -0.3 -0.1
Alzheimer’s Disease (in mother) 0.8 0.9 1.3 1.1 1.1 0.3
Alzheimer’s Disease (in father) 0.9 1.0 1.6 1.2 -0.7 1.0
Alzheimer’s Disease (including proxy) 0.3 0.5 1.1 1.0 0.3 0.5
Crohns Disease (2017) 3.4 7.5 13.2 -2.4 -1.9 -3.6
Irritable Bowel Disease (IBD) 1.6 3.8 10.0 -0.9 -0.8 -3.2
Ulcerative Colitis (UC) 0.6 1.1 1.7 1.2 0.3 -1.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.7 1.3 1.7 -1.3 -0.9 -1.2
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 -0.2 0.7 -0.4
Breast Cancer 0.9 2.1 6.1 -0.5 -2.5 -0.2
Ovarian Cancer 0.5 0.6 0.9 -0.2 -0.9 0.9
Prostate Cancer 1.0 1.4 3.3 -1.8 -0.7 0.5
Age at First Birth 0.0 0.0 0.1 -0.2 0.2 -0.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.5 1.2 -0.5 0.1 -1.1
Coronary Artery Disease (CAD) 0.5 0.6 1.1 -0.8 -1.0 0.0
Crohns Disease (2012) 1.3 2.2 4.7 -1.0 -0.9 -2.2
Mean Putamen Volume 0.4 0.5 0.9 -0.9 -0.4 -0.7
Fasting Glucose 0.3 0.4 0.4 -0.6 -0.6 -0.7
HbA1C 0.8 0.9 2.3 -0.4 -1.5 -0.3
HDL Cholesterol 0.8 1.3 2.2 1.3 0.1 1.5
LDL Cholesterol 1.2 2.0 2.9 1.7 1.1 1.4
Lupus 6.8 10.3 12.9 -3.6 -3.0 -2.9
Neuroticism (2016) 0.6 0.9 2.1 0.3 -1.5 0.7
Primary Biliary Cirrhosis 5.2 7.4 9.4 -2.6 -3.1 -2.4
Rheumatoid Arthritis 3.6 5.0 8.5 -2.3 -2.9 -1.1
Schizophrenia (2014) 0.5 1.1 2.4 1.5 0.5 -0.9
Triglycerides 0.2 0.3 0.6 -0.5 -0.3 -0.8
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.7 0.5 0.8 0.5
Ulcerative Colitis 0.7 0.9 1.9 1.4 0.8 -0.6
Blood Eosinophil Count 0.2 1.6 4.5 -0.1 2.1 -0.3
Blood Platelet Count 1.7 20.0 21.1 -4.5 -4.3 -4.6
Blood Red Count 0.2 1.7 4.1 -0.7 -0.8 -2.0
Blood White Count 1.6 12.1 16.2 4.0 3.4 3.0
Heel T-Score 0.6 4.5 8.6 -1.6 -2.9 -1.4
BMI 0.2 1.3 2.4 -1.1 1.6 -0.1
Height 0.4 8.6 25.5 0.6 0.1 5.0
Waist Hip Ratio (WHR) 0.3 1.5 2.3 -1.3 -0.8 -1.5
Systolic Blood Pressure 0.4 2.0 5.2 -0.7 -0.6 -2.3
Smoking Status 0.1 0.3 0.5 0.7 0.3 0.7
Allergy or Eczema 0.2 0.4 1.0 -0.4 -1.0 -0.3
Cardiovascular Disease 0.3 0.9 1.3 -0.8 -1.2 -0.9
Hypothyroidism (self reported) 7.4 17.1 28.2 -5.3 -4.3 -2.1
Respiratory disease 0.5 1.1 2.5 1.6 0.9 0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.1 -0.6 -0.0 -1.4
Lung FEV1/FVC ratio 0.8 4.1 9.1 1.1 1.4 3.0
Lung FVC 0.2 1.3 2.3 -1.2 0.0 -1.5
Neuroticism 0.2 0.6 1.3 -0.5 -1.1 0.4
Chronotype (morning person) 3.6 8.3 13.9 -2.8 -1.8 -3.7
Hair Pigment 0.0 0.9 1.5 0.6 1.2 -1.0
Tanning 0.1 1.5 2.1 -1.3 -1.4 0.8
Hand grip strength (left) 0.8 2.2 5.5 -1.1 0.0 -2.4
Number of treatments/medications taken 1.4 2.5 4.8 -2.2 -1.1 -1.1
Average weekly spirits intake 0.2 0.3 0.7 0.4 0.1 0.8
Sensitivity / hurt feelings 0.4 0.7 1.2 0.9 -0.1 1.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.1 1.0 -0.0 0.7
Hearing difficulty/problems: Yes 0.7 1.0 1.7 1.0 0.6 1.3
Relative age of first facial hair 0.1 0.2 0.4 -0.5 -0.3 0.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.5 0.6 0.0 0.7
Ever used hormone-replacement therapy (HRT) 2.6 3.3 4.9 -2.2 -1.9 -1.2
Ever had hysterectomy (womb removed) 1.0 1.1 2.2 -1.1 0.1 -1.5
Systolic blood pressure, automated reading 0.3 0.8 2.4 0.2 -0.1 -1.5
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.4 -0.6 -1.2 -0.6
Angina 1.0 1.4 1.7 -1.3 -1.0 -1.2
Medication for hormone replacement therapy 0.6 0.6 0.9 -0.9 -0.4 -1.0
Vitamin and mineral supplements 0.5 0.7 1.4 -1.2 -0.0 -0.8
Supplements: Zinc 0.7 0.8 2.3 0.3 -0.2 1.5
Medication: Co-codamol 0.4 0.5 1.1 0.2 1.1 0.5
Medication: Metformin 1.6 2.3 6.1 -2.5 0.2 -0.9
Diabetes (father) 0.3 0.3 0.9 -0.3 -1.0 -0.3
Diabetes (mother) 0.1 0.1 0.2 -0.4 -0.4 -0.0
Severe depression (siblings) 1.3 1.5 3.8 1.9 0.2 0.7
Pack years adult smoking proportion 0.2 0.3 0.9 -0.3 -0.3 -0.9
Impedance of leg (right) 0.6 2.7 6.0 2.4 0.7 1.3
Leg fat-free mass (left) 0.2 0.9 2.5 -1.6 -0.0 0.3
Trunk fat percentage 0.1 0.3 0.7 -0.0 0.4 0.8
Hand grip strength (right) 1.1 3.0 5.9 -1.8 -0.1 -2.4
Townsend deprivation index at recruitment 0.1 0.1 0.1 0.0 0.4 -0.4
Current tobacco smoking 0.4 0.7 1.3 1.2 -0.0 0.9
Average weekly fortified wine intake 0.6 0.7 1.4 -0.4 -0.7 1.2
Maternal smoking around birth 0.1 0.2 0.4 0.6 0.2 0.5
Fed-up feelings 1.2 2.3 3.5 1.6 0.8 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 2.4 1.5 0.1 0.8
Relative age voice broke 0.2 0.4 0.6 -0.7 0.7 -0.2
Taking other prescription medications 0.3 0.5 0.9 -0.9 -0.8 0.4
Age when periods started (menarche) 0.6 1.6 2.7 1.4 1.6 0.2
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.3 -1.0 0.2 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.9 -0.6 -0.3 -1.7
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 4.6 -0.7 0.5 -2.1
Qualifications: CSEs or equivalent 0.5 0.6 1.5 -0.7 -0.2 1.2
Serious illness, injury or assault to yourself 1.0 1.2 2.0 0.8 1.0 1.4
High blood pressure 0.2 0.4 1.0 -0.3 -0.4 -1.0
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.1 -0.4 -0.0
Multivitamins +/- minerals 1.3 1.7 2.7 1.5 0.6 1.6
Stomach or abdominal pain in last month 2.4 3.0 5.3 1.2 2.3 1.5
Supplements: Glucosamine 0.0 0.0 0.0 -0.1 0.1 0.1
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 -0.0 0.3 0.5
Medication: Atenolol 0.5 0.6 1.3 -0.2 -0.7 -1.1
Medication: Levothyroxine sodium 3.8 6.4 9.1 -3.0 -2.6 -1.8
Sitting height 0.0 0.1 0.2 -0.4 0.5 0.3
Chronic bronchitis/emphysema (father) 2.9 3.4 7.8 2.8 0.2 1.5
High blood pressure (mother) 0.8 1.1 2.1 0.8 -0.7 1.4
Body mass index (BMI) 0.2 0.9 2.2 -1.5 0.6 0.1
Impedance of leg (left) 0.4 2.0 4.8 2.2 0.6 0.8
Leg predicted mass (left) 0.2 0.9 2.5 -1.6 -0.0 0.4
Trunk fat mass 0.1 0.5 1.3 -0.3 0.4 1.2
Waist circumference 0.3 1.0 1.7 -1.3 0.9 0.7
Number of incorrect matches in round 0.1 0.2 0.6 0.8 0.3 0.1
Past tobacco smoking 0.1 0.1 0.2 0.4 -0.2 -0.4
Alcohol usually taken with meals 1.1 1.7 2.7 -1.6 -1.6 0.3
Nervous feelings 0.2 0.3 0.6 0.2 0.5 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.1 1.8 0.7 1.1
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.4 0.4 -0.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.6 0.6 -0.1 0.8
Had menopause 1.0 1.2 2.5 -1.6 -0.4 -1.0
Had other major operations 1.7 2.0 3.2 1.8 1.4 0.9
Forced vital capacity (FVC) 0.0 0.0 0.0 -0.1 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.7 6.0 -1.8 -1.4 -2.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.4 0.5 0.4 0.6
Qualifications: None of the above 0.6 1.2 2.9 -0.6 -0.6 -1.7
Financial difficulties in last 2 years 1.5 2.0 4.9 0.9 -0.5 2.2
Mouth/teeth dental problems 1.0 1.5 2.3 -1.3 0.8 -1.5
Heart attack 0.2 0.3 0.6 -0.4 0.8 -0.2
Allergy 0.0 0.0 0.1 0.3 -0.1 0.1
Pain all over the body in last month 0.3 0.3 0.8 -0.2 0.4 -0.9
Diabetes (self-reported) 0.3 0.5 1.3 -1.1 0.0 -0.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 -0.2 0.2 0.4
Medication: Ramipril 0.2 0.3 0.8 -0.1 0.1 0.9
Medication: Simvastatin 0.7 1.0 1.9 -1.4 -0.6 -0.8
Fluid intelligence score 0.1 0.1 0.2 0.4 0.3 0.3
Illnesses of siblings 0.2 0.2 0.6 -0.1 0.3 0.8
Neuroticism score 0.1 0.3 0.6 0.8 0.3 0.4
Weight 0.2 1.0 2.0 -1.4 0.6 0.8
Impedance of arm (right) 0.5 2.6 7.3 2.7 0.5 0.4
Arm fat percentage (right) 0.1 0.3 0.6 0.1 0.8 0.6
Trunk fat-free mass 0.2 1.2 2.5 -1.6 0.1 1.0
Hip circumference 0.3 1.2 1.8 -0.9 1.4 1.1
Time employed in main current job 0.5 0.6 1.0 -0.3 1.0 -0.9
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.2 0.0 -0.5
Father’s age at death 0.2 0.3 0.5 0.7 -0.5 0.1
Worrier / anxious feelings 1.1 2.0 4.1 0.9 -2.0 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.0 0.2 1.4 -0.9
Falls in the last year 0.6 0.9 2.5 0.3 1.6 -0.1
Hair/balding pattern: Pattern 3 0.4 0.6 1.0 -1.0 -0.8 -0.2
Number of live births 3.2 4.5 5.4 2.1 -1.9 2.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.2 0.0 0.3 1.1
Pulse rate 0.0 0.1 0.1 0.3 0.3 -0.2
Happiness 0.8 0.9 2.3 -0.3 0.6 -1.5
Noisy workplace 1.2 1.5 3.1 1.8 1.0 0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.5 0.5 0.7 0.4
Serious illness, injury or assault of a close relative in last 2 years 2.9 3.3 5.2 2.0 0.8 2.3
Mouth/teeth dental problems: Dentures 1.3 2.2 3.6 -1.9 -1.7 -0.1
Asthma 0.6 1.3 2.7 1.6 0.7 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.1 0.3 -0.0 1.1
Medication: Cholesterol lowering 0.6 0.9 1.4 -1.1 -0.3 -1.2
Depression (self-reported) 0.0 0.0 0.1 -0.1 0.1 -0.2
Medication: Lansoprazole 2.0 2.3 4.4 -0.1 -2.1 1.6
Prospective memory result 2.2 2.7 3.3 -1.8 -1.6 -1.6
Lung cancer (father) 0.5 0.5 0.8 -0.2 0.9 -0.8
Illnesses of mother 1.7 2.1 4.7 -1.0 0.7 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 -0.4 -0.1 0.6
Pulse wave Arterial Stiffness index 0.6 0.7 1.6 -0.2 -1.3 0.7
Impedance of arm (left) 0.4 1.7 4.8 2.2 0.1 0.4
Arm fat mass (right) 0.1 0.5 0.6 -0.7 0.6 0.7
Trunk predicted mass 0.2 1.1 2.4 -1.5 0.2 1.0
Standing height 0.1 0.7 2.1 -0.1 0.0 1.5
Length of working week for main job 0.5 0.5 1.1 -1.0 0.3 -0.6
Exposure to tobacco smoke at home 0.0 0.0 0.1 0.4 -0.0 -0.1
Breastfed as a baby 1.2 1.5 2.6 -1.6 -1.2 -0.8
Tense / ‘highly strung’ 0.7 1.1 1.9 -1.4 -0.6 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.7 1.6 0.9 1.0
Hair/balding pattern: Pattern 4 0.3 0.8 1.1 0.3 1.1 -1.0
Birth weight of first child 0.1 0.2 0.4 -0.1 0.2 -0.6
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.6 -0.3 0.8
Pulse wave reflection index 0.6 0.7 1.6 -0.1 -0.7 1.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.6 0.4 -1.3 -0.3
Loud music exposure frequency 0.5 0.5 1.3 -1.1 -0.5 -0.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 3.0 0.1 0.4 1.7
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 3.5 0.9 1.9 0.2
Blood clot in the leg (DVT) 0.4 0.5 1.0 -0.3 -0.6 -1.0
Medication: Paracetamol 0.9 1.5 1.6 -1.2 -1.2 1.2
Headache pain in last month 0.4 0.7 1.5 -0.7 -1.2 0.0
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 5.6 2.2 0.7 2.4
Glaucoma (self-reported) 1.3 1.5 4.3 0.1 2.1 -0.3
Gout (self-reported) 0.1 0.1 0.3 -0.4 0.1 -0.5
Hypothyroidism/myxoedema (self-reported) 5.0 9.7 14.8 -3.9 -3.6 -1.2
Medication: Amlodipine 0.6 0.9 1.8 -1.0 -1.3 0.0
Medication: Ventolin 100micrograms inhaler 0.7 0.8 2.2 1.5 0.4 -0.4
Birth weight 0.6 1.4 1.7 -1.3 -1.3 0.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.4 -0.1 0.1 -0.6
High blood pressure (siblings) 0.2 0.2 0.5 -0.0 0.7 -0.4
Forced vital capacity (FVC), Best measure 0.1 0.2 0.3 -0.6 -0.5 0.1
Body fat percentage 0.1 0.4 0.7 0.2 0.7 0.8
Leg fat percentage (right) 0.2 0.6 0.9 -0.0 0.9 1.0
Arm fat-free mass (right) 0.4 1.8 4.8 -2.2 -0.2 0.8
Exposure to tobacco smoke outside home 0.3 0.4 1.3 -0.2 -1.1 -0.0
Comparative body size at age 10 0.5 1.3 2.9 1.7 0.6 0.7
Number of full brothers 0.1 0.1 0.2 0.3 -0.4 0.4
Worry too long after embarrassment 0.8 1.4 2.1 -1.3 -0.6 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.4 0.6 1.2 0.2
Wheeze or whistling in the chest in last year 1.2 2.2 4.8 1.3 -0.2 2.2
Number of children fathered 0.2 0.2 0.4 0.1 0.3 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.1 2.8 -0.8 -0.2 -1.7
Age at first live birth 0.5 0.8 2.2 0.2 0.5 -1.5
Pulse wave peak to peak time 0.7 0.8 2.0 0.2 1.4 -0.6
Health satisfaction 2.3 2.9 5.2 -1.7 -0.8 -2.3
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.1 -0.3 0.5
Qualifications: College or University degree 1.1 3.5 5.3 -2.3 -0.7 -2.2
Eye problems/disorders: None of the above 1.0 1.1 2.4 0.8 1.6 -0.6
Mouth/teeth dental problems: Loose teeth 1.4 1.7 2.7 1.6 -0.0 1.6
Emphysema/chronic bronchitis 0.6 0.7 1.2 -1.1 -0.7 -0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 4.1 1.0 1.2 -2.0
Neck or shoulder pain in last month 1.0 1.4 2.4 1.3 0.5 1.6
Medication: Blood pressure 2.5 4.4 7.5 -2.7 -1.7 -1.7
Angina (self-reported) 1.0 1.3 1.8 -1.3 -0.8 -1.2
Migraine (self-reported) 0.3 0.4 0.7 -0.8 -0.5 -0.5
Medication: Ibuprofen 0.4 0.5 1.2 -1.1 -0.3 0.3
Medication: Allopurinol 0.6 0.9 1.3 -0.9 -0.6 -1.2
Medication: Omeprazole 0.8 1.0 2.6 -1.6 -0.0 -0.5
Medication: Seretide 50 evohaler 2.7 3.1 8.4 2.9 0.6 0.7
Mean time to correctly identify matches 0.1 0.1 0.4 -0.6 -0.1 0.1
Heart disease (mother) 0.3 0.4 0.6 0.6 0.1 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.7 -0.2 -0.9 -0.4
Whole body fat mass 0.1 0.5 1.1 -0.4 0.5 1.1
Leg fat mass (right) 0.2 0.6 0.8 -0.8 0.6 0.9
Arm predicted mass (right) 0.3 1.3 3.4 -1.9 -0.1 0.8
Pulse rate, automated reading 0.6 1.9 2.4 1.4 1.2 1.5
Alcohol intake frequency. 0.7 1.5 2.3 -0.8 -1.3 -1.5
Comparative height size at age 10 0.0 0.1 0.2 0.1 0.4 0.5
Number of full sisters 2.8 3.4 6.8 -2.6 -1.3 -1.3
Suffer from ‘nerves’ 0.6 0.9 2.1 0.6 1.5 -0.3
Overall health rating 0.4 0.9 2.6 0.4 1.6 -0.3
Chest pain or discomfort 0.1 0.1 0.2 0.2 -0.2 0.4
Had major operations 0.8 1.0 2.2 0.4 -0.7 1.5
Age at last live birth 0.3 0.5 0.9 0.9 -0.7 0.1
Family relationship satisfaction 0.4 0.5 1.1 1.0 0.2 0.5
Leg pain on walking 0.4 0.5 1.1 -0.1 -0.6 -1.1
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.1 5.6 1.3 1.3 2.4
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.5 1.3 1.9 -0.0
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 3.5 -1.4 -1.2 -1.9
Medication: Aspirin 1.1 1.5 2.7 -1.4 -1.6 -0.0
Supplements: Vitamin C 0.4 0.5 0.7 0.4 -0.8 -0.8
Knee pain experienced in last month 2.2 3.4 6.5 1.7 1.0 2.5
Hypertension (Self-reported) 0.2 0.6 1.1 -0.2 -0.8 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.7 -0.3 0.8 0.8
Illnesses of father: Heart disease 0.7 0.9 1.6 -1.1 -1.3 -0.2
Illnesses of siblings: Diabetes 1.4 1.7 2.5 0.5 -1.5 -1.6
Smoking status: Previous 0.2 0.3 0.4 -0.6 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 0.7 1.3 0.4
Whole body fat-free mass 0.2 1.2 3.3 -1.8 -0.0 0.6
Leg fat-free mass (right) 0.2 0.8 2.5 -1.6 -0.1 0.1
Arm fat percentage (left) 0.1 0.3 0.4 -0.2 0.6 0.7
Average weekly red wine intake 0.6 0.9 2.6 0.1 0.1 1.6
Handedness (chirality/laterality): Left-handed 1.3 1.6 2.6 1.4 0.1 1.6
Mood swings 1.1 1.9 2.2 1.5 1.2 1.5
Loneliness, isolation 2.0 2.7 3.8 1.4 2.0 1.5
Long-standing illness, disability or infirmity 0.4 0.6 1.5 -0.4 0.5 -1.2
Ever had bowel cancer screening 1.8 2.1 3.6 0.6 -1.9 1.6
Diabetes diagnosed by doctor 0.3 0.5 0.9 -1.0 -0.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.8 2.0 4.4 1.2 0.3 2.1
Friendships satisfaction 1.4 1.7 2.5 1.6 1.5 0.6
Qualifications: nursing, teaching 0.1 0.2 0.3 -0.5 0.5 0.3
Commuting to job workplace: Walk 0.9 0.9 1.7 -1.0 -1.3 0.3
Eye problems/disorders: Cataract 1.3 1.5 2.4 -1.6 -1.5 0.1
Mouth/teeth dental problems: Mouth ulcers 2.5 4.0 6.0 2.5 0.6 2.3
Medication for cholesterol 0.2 0.2 0.6 -0.1 0.8 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.4 0.5 -1.8 0.8
Back pain experienced in last month 0.7 1.0 1.9 0.8 1.4 0.5
Mineral and other dietary supplements 0.0 0.1 0.1 0.3 -0.1 -0.2
Breast cancer (self-reported) 2.6 3.1 8.2 0.5 2.9 -1.0
Asthma (self-reported) 0.4 0.7 1.7 1.3 0.6 0.4
Osteoporosis (self-reported) 0.1 0.2 0.3 -0.1 0.4 -0.6
Osteoarthritis (self-reported) 3.7 4.7 10.2 2.0 -0.1 3.2
Medication: Aspirin 0.9 1.2 2.5 -0.9 -1.6 0.7
Medication: Gliclazide 0.1 0.1 0.2 -0.2 0.5 0.1
Illnesses of father: None of the above (group 1) 1.5 1.9 4.1 0.6 2.0 1.1
Smoking status: Current 0.5 0.8 1.7 1.3 0.1 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.2 0.4 0.2 -0.3
Whole body water mass 0.2 1.3 3.4 -1.9 -0.1 0.6
Leg predicted mass (right) 0.2 0.9 2.6 -1.6 -0.1 0.1
Arm fat mass (left) 0.1 0.6 1.4 -1.2 0.3 0.6
Number of self-reported non-cancer illnesses 0.4 0.7 1.7 -0.7 -1.3 -0.3
Average weekly champagne plus white wine intake 1.5 2.1 2.7 -1.6 -1.2 -1.5
Miserableness 1.8 3.2 5.3 2.3 1.6 1.4
Guilty feelings 0.8 1.2 1.7 -0.7 -1.3 -1.2
Wears glasses or contact lenses 0.7 0.8 1.4 -1.0 -0.5 1.2
Ever taken oral contraceptive pill 1.4 1.6 4.7 2.2 0.4 0.2
Hearing aid user 0.0 0.0 0.1 -0.3 -0.1 -0.1
Mother’s age at death 1.4 1.8 2.2 1.5 1.2 1.4
Financial situation satisfaction 0.2 0.2 0.3 0.5 -0.3 0.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.4 -0.8 -1.2 0.6
Commuting to job workplace: Public transport 0.6 0.7 1.2 -0.4 -1.1 0.8
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 -0.4 0.6 -0.2
Medication: Blood pressure 0.1 0.2 0.4 0.6 -0.5 -0.1
Pain type(s) experienced in last month: Hip pain 1.9 2.4 4.2 2.0 1.7 0.0
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.0 -0.1 -0.2 1.0
High cholesterol (Self-reported) 0.3 0.6 1.3 -0.5 -0.5 -1.1
Medication: Bendroflumethiazide 0.5 0.7 1.6 0.3 -0.7 -1.2
Medication: Paracetamol 1.0 1.6 1.8 -1.2 -1.2 1.4
Medication: Lisinopril 2.8 3.7 8.0 -1.6 -0.7 -2.8
Medication: Atorvastatin 0.1 0.1 0.2 0.5 -0.1 0.3
Illnesses of father: High blood pressure 1.6 1.9 4.7 -1.0 0.0 -2.2
Alcohol drinker status: Never 1.0 1.3 1.7 -1.3 -0.6 -1.3
Ever smoked 0.0 0.1 0.1 -0.3 -0.1 0.3
Basal metabolic rate 0.2 1.1 2.8 -1.7 0.2 0.7
Leg fat percentage (left) 0.1 0.4 0.7 -0.1 0.9 0.7
Arm fat-free mass (left) 0.3 1.5 3.6 -1.9 -0.0 0.9
Number of operations (self-reported) 1.4 2.1 3.3 1.5 1.0 1.8
Average weekly beer plus cider intake 1.5 2.2 4.3 -1.1 1.1 -2.1
Irritability 1.4 2.3 5.6 1.2 -0.0 2.4
Risk taking 0.5 0.7 1.6 -1.3 -0.1 -0.8
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.2 0.6 -1.5 1.3
Fractured/broken bones in last 5 years 1.9 2.4 3.6 1.5 1.1 1.9
Age started oral contraceptive pill 0.5 0.6 1.2 0.2 -1.1 -0.8
Diastolic blood pressure, automated reading 0.9 2.7 4.3 -1.9 0.2 -2.1
Ever depressed for a whole week 1.7 2.1 3.2 1.5 0.8 1.8
Unable to work because of sickness or disability 0.1 0.1 0.4 0.1 -0.1 0.6
Commuting to job workplace: Cycle 1.6 1.9 3.3 -1.5 -0.4 -1.8
Myopia 0.7 1.0 2.0 -1.4 -0.8 -0.6
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.5 0.3 0.7 0.7
Cholesterol lowering medication 0.2 0.4 0.7 -0.0 -0.6 0.8
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 4.6 -2.2 -0.4 0.6
Pain experienced in last month 0.8 1.3 2.3 -0.8 -1.0 -1.5
Supplements: Calcium 1.4 1.6 3.7 -0.9 0.4 -1.9
Basal cell carcinoma (self-reported) 0.2 0.3 0.8 0.0 0.0 0.9
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 -0.4 0.6 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 0.1 -0.7 -0.7
Heart disease (siblings) 1.8 2.2 5.2 -0.9 -0.7 -2.3
Alcohol drinker status: Previous 0.9 1.0 1.6 0.2 -1.2 -1.3
Pack years of smoking 0.6 0.8 1.4 -0.8 -0.7 -1.2
Impedance of whole body 0.3 1.5 4.2 2.1 -0.0 0.5
Leg fat mass (left) 0.1 0.5 0.7 -0.8 0.6 0.7
Arm predicted mass (left) 0.2 1.3 2.5 -1.6 0.2 1.1