TWAS hub - TYK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.266	0.0858	7.0e-03	0.060	NA	0.065	NA	0.116	3.3e-03	NA	2.3e-03	NA	6.0e-05
2	YFS	Blood	0.127	0.0221	0.0e+00	0.062	0.093	0.095	0.099	0.100	1.7e-19	6.3e-29	1.7e-29	1.6e-30	8.5e-31
3	TCGA	Thyroid Carcinoma	0.110	0.0500	7.1e-05	0.008	0.048	0.023	NA	0.029	5.1e-02	1.9e-05	2.2e-03	NA	7.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hypothyroidism (self reported)	7.4	17.1	28.2	-5.3	-4.3	-2.1
Lupus	6.8	10.3	12.9	-3.6	-3.0	-2.9
Primary Biliary Cirrhosis	5.2	7.4	9.4	-2.6	-3.1	-2.4
Hypothyroidism/myxoedema (self-reported)	5.0	9.7	14.8	-3.9	-3.6	-1.2
Medication: Levothyroxine sodium	3.8	6.4	9.1	-3.0	-2.6	-1.8
Osteoarthritis (self-reported)	3.7	4.7	10.2	2.0	-0.1	3.2
Rheumatoid Arthritis	3.6	5.0	8.5	-2.3	-2.9	-1.1
Chronotype (morning person)	3.6	8.3	13.9	-2.8	-1.8	-3.7
Crohns Disease (2017)	3.4	7.5	13.2	-2.4	-1.9	-3.6
Number of live births	3.2	4.5	5.4	2.1	-1.9	2.3
Chronic bronchitis/emphysema (father)	2.9	3.4	7.8	2.8	0.2	1.5
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	5.2	2.0	0.8	2.3
Number of full sisters	2.8	3.4	6.8	-2.6	-1.3	-1.3
Medication: Lisinopril	2.8	3.7	8.0	-1.6	-0.7	-2.8
Medication: Seretide 50 evohaler	2.7	3.1	8.4	2.9	0.6	0.7
Ever used hormone-replacement therapy (HRT)	2.6	3.3	4.9	-2.2	-1.9	-1.2
Breast cancer (self-reported)	2.6	3.1	8.2	0.5	2.9	-1.0
Medication: Blood pressure	2.5	4.4	7.5	-2.7	-1.7	-1.7
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.1	5.6	1.3	1.3	2.4
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	6.0	2.5	0.6	2.3
Stomach or abdominal pain in last month	2.4	3.0	5.3	1.2	2.3	1.5
Health satisfaction	2.3	2.9	5.2	-1.7	-0.8	-2.3
Prospective memory result	2.2	2.7	3.3	-1.8	-1.6	-1.6
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	5.6	2.2	0.7	2.4
Knee pain experienced in last month	2.2	3.4	6.5	1.7	1.0	2.5
Medication: Lansoprazole	2.0	2.3	4.4	-0.1	-2.1	1.6
Loneliness, isolation	2.0	2.7	3.8	1.4	2.0	1.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	3.5	-1.4	-1.2	-1.9
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.2	2.0	1.7	0.0
Fractured/broken bones in last 5 years	1.9	2.4	3.6	1.5	1.1	1.9
Ever had bowel cancer screening	1.8	2.1	3.6	0.6	-1.9	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	4.4	1.2	0.3	2.1
Miserableness	1.8	3.2	5.3	2.3	1.6	1.4
Heart disease (siblings)	1.8	2.2	5.2	-0.9	-0.7	-2.3
Blood Platelet Count	1.7	20.0	21.1	-4.5	-4.3	-4.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.6	-0.7	0.5	-2.1
Had other major operations	1.7	2.0	3.2	1.8	1.4	0.9
Illnesses of mother	1.7	2.1	4.7	-1.0	0.7	-2.2
Ever depressed for a whole week	1.7	2.1	3.2	1.5	0.8	1.8
Irritable Bowel Disease (IBD)	1.6	3.8	10.0	-0.9	-0.8	-3.2
Blood White Count	1.6	12.1	16.2	4.0	3.4	3.0
Medication: Metformin	1.6	2.3	6.1	-2.5	0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	6.0	-1.8	-1.4	-2.5
Illnesses of father: High blood pressure	1.6	1.9	4.7	-1.0	0.0	-2.2
Commuting to job workplace: Cycle	1.6	1.9	3.3	-1.5	-0.4	-1.8
Financial difficulties in last 2 years	1.5	2.0	4.9	0.9	-0.5	2.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.5	1.3	1.9	-0.0
Illnesses of father: None of the above (group 1)	1.5	1.9	4.1	0.6	2.0	1.1
Average weekly champagne plus white wine intake	1.5	2.1	2.7	-1.6	-1.2	-1.5
Average weekly beer plus cider intake	1.5	2.2	4.3	-1.1	1.1	-2.1
Number of treatments/medications taken	1.4	2.5	4.8	-2.2	-1.1	-1.1
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.7	1.6	-0.0	1.6
Illnesses of siblings: Diabetes	1.4	1.7	2.5	0.5	-1.5	-1.6
Friendships satisfaction	1.4	1.7	2.5	1.6	1.5	0.6
Ever taken oral contraceptive pill	1.4	1.6	4.7	2.2	0.4	0.2
Mother’s age at death	1.4	1.8	2.2	1.5	1.2	1.4
Number of operations (self-reported)	1.4	2.1	3.3	1.5	1.0	1.8
Irritability	1.4	2.3	5.6	1.2	-0.0	2.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.6	-2.2	-0.4	0.6
Supplements: Calcium	1.4	1.6	3.7	-0.9	0.4	-1.9
Crohns Disease (2012)	1.3	2.2	4.7	-1.0	-0.9	-2.2
Severe depression (siblings)	1.3	1.5	3.8	1.9	0.2	0.7
Multivitamins +/- minerals	1.3	1.7	2.7	1.5	0.6	1.6
Mouth/teeth dental problems: Dentures	1.3	2.2	3.6	-1.9	-1.7	-0.1
Glaucoma (self-reported)	1.3	1.5	4.3	0.1	2.1	-0.3
Medication for pain relief, constipation, heartburn	1.3	2.2	4.1	1.0	1.2	-2.0
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.6	1.4	0.1	1.6
Eye problems/disorders: Cataract	1.3	1.5	2.4	-1.6	-1.5	0.1
LDL Cholesterol	1.2	2.0	2.9	1.7	1.1	1.4
Fed-up feelings	1.2	2.3	3.5	1.6	0.8	1.9
Noisy workplace	1.2	1.5	3.1	1.8	1.0	0.7
Breastfed as a baby	1.2	1.5	2.6	-1.6	-1.2	-0.8
Wheeze or whistling in the chest in last year	1.2	2.2	4.8	1.3	-0.2	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.4	0.5	-1.8	0.8
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.2	0.6	-1.5	1.3
Hand grip strength (right)	1.1	3.0	5.9	-1.8	-0.1	-2.4
Alcohol usually taken with meals	1.1	1.7	2.7	-1.6	-1.6	0.3
Worrier / anxious feelings	1.1	2.0	4.1	0.9	-2.0	1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.5	0.9	1.9	0.2
Qualifications: College or University degree	1.1	3.5	5.3	-2.3	-0.7	-2.2
Medication: Aspirin	1.1	1.5	2.7	-1.4	-1.6	-0.0
Mood swings	1.1	1.9	2.2	1.5	1.2	1.5
Prostate Cancer	1.0	1.4	3.3	-1.8	-0.7	0.5
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	-1.1	0.1	-1.5
Angina	1.0	1.4	1.7	-1.3	-1.0	-1.2
Serious illness, injury or assault to yourself	1.0	1.2	2.0	0.8	1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.1	1.8	0.7	1.1
Had menopause	1.0	1.2	2.5	-1.6	-0.4	-1.0
Mouth/teeth dental problems	1.0	1.5	2.3	-1.3	0.8	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.8	-0.8	-0.2	-1.7
Eye problems/disorders: None of the above	1.0	1.1	2.4	0.8	1.6	-0.6
Neck or shoulder pain in last month	1.0	1.4	2.4	1.3	0.5	1.6
Angina (self-reported)	1.0	1.3	1.8	-1.3	-0.8	-1.2
Medication: Paracetamol	1.0	1.6	1.8	-1.2	-1.2	1.4
Alcohol drinker status: Never	1.0	1.3	1.7	-1.3	-0.6	-1.3
Alzheimer’s Disease (in father)	0.9	1.0	1.6	1.2	-0.7	1.0
Breast Cancer	0.9	2.1	6.1	-0.5	-2.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.3	-1.0	0.2	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.7	1.6	0.9	1.0
Medication: Paracetamol	0.9	1.5	1.6	-1.2	-1.2	1.2
Commuting to job workplace: Walk	0.9	0.9	1.7	-1.0	-1.3	0.3
Medication: Aspirin	0.9	1.2	2.5	-0.9	-1.6	0.7
Diastolic blood pressure, automated reading	0.9	2.7	4.3	-1.9	0.2	-2.1
Alcohol drinker status: Previous	0.9	1.0	1.6	0.2	-1.2	-1.3
Alzheimer’s Disease (in mother)	0.8	0.9	1.3	1.1	1.1	0.3
HbA1C	0.8	0.9	2.3	-0.4	-1.5	-0.3
HDL Cholesterol	0.8	1.3	2.2	1.3	0.1	1.5
Lung FEV1/FVC ratio	0.8	4.1	9.1	1.1	1.4	3.0
Hand grip strength (left)	0.8	2.2	5.5	-1.1	0.0	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.4	1.5	0.1	0.8
High blood pressure (mother)	0.8	1.1	2.1	0.8	-0.7	1.4
Happiness	0.8	0.9	2.3	-0.3	0.6	-1.5
Worry too long after embarrassment	0.8	1.4	2.1	-1.3	-0.6	-1.4
Medication: Omeprazole	0.8	1.0	2.6	-1.6	-0.0	-0.5
Had major operations	0.8	1.0	2.2	0.4	-0.7	1.5
Guilty feelings	0.8	1.2	1.7	-0.7	-1.3	-1.2
Pain experienced in last month	0.8	1.3	2.3	-0.8	-1.0	-1.5
Depressed Affect (Nagel 2018)	0.7	1.4	1.7	1.1	1.2	1.3
Reaction Time	0.7	1.3	1.7	-1.3	-0.9	-1.2
Ulcerative Colitis	0.7	0.9	1.9	1.4	0.8	-0.6
Hearing difficulty/problems: Yes	0.7	1.0	1.7	1.0	0.6	1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	-0.6	-1.2	-0.6
Supplements: Zinc	0.7	0.8	2.3	0.3	-0.2	1.5
Medication: Simvastatin	0.7	1.0	1.9	-1.4	-0.6	-0.8
Tense / ‘highly strung’	0.7	1.1	1.9	-1.4	-0.6	-1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	3.0	0.1	0.4	1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.2	1.5	0.4	-0.4
Pulse wave peak to peak time	0.7	0.8	2.0	0.2	1.4	-0.6
Alcohol intake frequency.	0.7	1.5	2.3	-0.8	-1.3	-1.5
Illnesses of father: Heart disease	0.7	0.9	1.6	-1.1	-1.3	-0.2
Back pain experienced in last month	0.7	1.0	1.9	0.8	1.4	0.5
Wears glasses or contact lenses	0.7	0.8	1.4	-1.0	-0.5	1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.4	-0.8	-1.2	0.6
Myopia	0.7	1.0	2.0	-1.4	-0.8	-0.6
Ulcerative Colitis (UC)	0.6	1.1	1.7	1.2	0.3	-1.3
Neuroticism (2016)	0.6	0.9	2.1	0.3	-1.5	0.7
Heel T-Score	0.6	4.5	8.6	-1.6	-2.9	-1.4
Medication for hormone replacement therapy	0.6	0.6	0.9	-0.9	-0.4	-1.0
Impedance of leg (right)	0.6	2.7	6.0	2.4	0.7	1.3
Average weekly fortified wine intake	0.6	0.7	1.4	-0.4	-0.7	1.2
Age when periods started (menarche)	0.6	1.6	2.7	1.4	1.6	0.2
Qualifications: None of the above	0.6	1.2	2.9	-0.6	-0.6	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.0	0.2	1.4	-0.9
Falls in the last year	0.6	0.9	2.5	0.3	1.6	-0.1
Asthma	0.6	1.3	2.7	1.6	0.7	0.8
Medication: Cholesterol lowering	0.6	0.9	1.4	-1.1	-0.3	-1.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	-0.2	-1.3	0.7
Pulse wave reflection index	0.6	0.7	1.6	-0.1	-0.7	1.3
Medication: Amlodipine	0.6	0.9	1.8	-1.0	-1.3	0.0
Birth weight	0.6	1.4	1.7	-1.3	-1.3	0.8
Emphysema/chronic bronchitis	0.6	0.7	1.2	-1.1	-0.7	-0.5
Medication: Allopurinol	0.6	0.9	1.3	-0.9	-0.6	-1.2
Pulse rate, automated reading	0.6	1.9	2.4	1.4	1.2	1.5
Suffer from ‘nerves’	0.6	0.9	2.1	0.6	1.5	-0.3
Average weekly red wine intake	0.6	0.9	2.6	0.1	0.1	1.6
Commuting to job workplace: Public transport	0.6	0.7	1.2	-0.4	-1.1	0.8
Pack years of smoking	0.6	0.8	1.4	-0.8	-0.7	-1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.4	-0.6	0.5	-1.2
Ovarian Cancer	0.5	0.6	0.9	-0.2	-0.9	0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.1	-0.8	-1.0	0.0
Schizophrenia (2014)	0.5	1.1	2.4	1.5	0.5	-0.9
Respiratory disease	0.5	1.1	2.5	1.6	0.9	0.2
Vitamin and mineral supplements	0.5	0.7	1.4	-1.2	-0.0	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.9	-0.6	-0.3	-1.7
Qualifications: CSEs or equivalent	0.5	0.6	1.5	-0.7	-0.2	1.2
Medication: Atenolol	0.5	0.6	1.3	-0.2	-0.7	-1.1
Impedance of arm (right)	0.5	2.6	7.3	2.7	0.5	0.4
Time employed in main current job	0.5	0.6	1.0	-0.3	1.0	-0.9
Lung cancer (father)	0.5	0.5	0.8	-0.2	0.9	-0.8
Length of working week for main job	0.5	0.5	1.1	-1.0	0.3	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.4	-1.3	-0.3
Loud music exposure frequency	0.5	0.5	1.3	-1.1	-0.5	-0.1
Comparative body size at age 10	0.5	1.3	2.9	1.7	0.6	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	0.6	1.2	0.2
Age at first live birth	0.5	0.8	2.2	0.2	0.5	-1.5
Smoking status: Current	0.5	0.8	1.7	1.3	0.1	0.9
Medication: Bendroflumethiazide	0.5	0.7	1.6	0.3	-0.7	-1.2
Risk taking	0.5	0.7	1.6	-1.3	-0.1	-0.8
Age started oral contraceptive pill	0.5	0.6	1.2	0.2	-1.1	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.6	1.6	1.1	0.4
Schizophrenia (2018)	0.4	0.7	1.5	1.2	-0.1	-0.8
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-0.5	0.1	-1.1
Mean Putamen Volume	0.4	0.5	0.9	-0.9	-0.4	-0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.5	0.8	0.5
Height	0.4	8.6	25.5	0.6	0.1	5.0
Systolic Blood Pressure	0.4	2.0	5.2	-0.7	-0.6	-2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	-0.6	-0.0	-1.4
Sensitivity / hurt feelings	0.4	0.7	1.2	0.9	-0.1	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	1.0	-0.0	0.7
Medication: Co-codamol	0.4	0.5	1.1	0.2	1.1	0.5
Current tobacco smoking	0.4	0.7	1.3	1.2	-0.0	0.9
Impedance of leg (left)	0.4	2.0	4.8	2.2	0.6	0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-1.0	-0.8	-0.2
Impedance of arm (left)	0.4	1.7	4.8	2.2	0.1	0.4
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.3	-0.6	-1.0
Headache pain in last month	0.4	0.7	1.5	-0.7	-1.2	0.0
Arm fat-free mass (right)	0.4	1.8	4.8	-2.2	-0.2	0.8
Medication: Ibuprofen	0.4	0.5	1.2	-1.1	-0.3	0.3
Overall health rating	0.4	0.9	2.6	0.4	1.6	-0.3
Family relationship satisfaction	0.4	0.5	1.1	1.0	0.2	0.5
Leg pain on walking	0.4	0.5	1.1	-0.1	-0.6	-1.1
Supplements: Vitamin C	0.4	0.5	0.7	0.4	-0.8	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	-0.3	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	0.7	1.3	0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.4	0.5	-1.2
Asthma (self-reported)	0.4	0.7	1.7	1.3	0.6	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	-0.7	-1.3	-0.3
Bipolar Disorder (2018)	0.3	0.4	0.9	-0.4	0.4	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.6	1.6	0.1	0.5	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	1.0	0.3	0.5
Fasting Glucose	0.3	0.4	0.4	-0.6	-0.6	-0.7
Waist Hip Ratio (WHR)	0.3	1.5	2.3	-1.3	-0.8	-1.5
Cardiovascular Disease	0.3	0.9	1.3	-0.8	-1.2	-0.9
Systolic blood pressure, automated reading	0.3	0.8	2.4	0.2	-0.1	-1.5
Diabetes (father)	0.3	0.3	0.9	-0.3	-1.0	-0.3
Taking other prescription medications	0.3	0.5	0.9	-0.9	-0.8	0.4
Waist circumference	0.3	1.0	1.7	-1.3	0.9	0.7
Pain all over the body in last month	0.3	0.3	0.8	-0.2	0.4	-0.9
Diabetes (self-reported)	0.3	0.5	1.3	-1.1	0.0	-0.6
Hip circumference	0.3	1.2	1.8	-0.9	1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.3	-0.0	1.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.1	0.3	1.1	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.3	-0.2	-1.1	-0.0
Migraine (self-reported)	0.3	0.4	0.7	-0.8	-0.5	-0.5
Heart disease (mother)	0.3	0.4	0.6	0.6	0.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.2	-0.9	-0.4
Arm predicted mass (right)	0.3	1.3	3.4	-1.9	-0.1	0.8
Age at last live birth	0.3	0.5	0.9	0.9	-0.7	0.1
Diabetes diagnosed by doctor	0.3	0.5	0.9	-1.0	-0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.0	-0.1	-0.2	1.0
High cholesterol (Self-reported)	0.3	0.6	1.3	-0.5	-0.5	-1.1
Arm fat-free mass (left)	0.3	1.5	3.6	-1.9	-0.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.1	-0.7	-0.7
Impedance of whole body	0.3	1.5	4.2	2.1	-0.0	0.5
Triglycerides	0.2	0.3	0.6	-0.5	-0.3	-0.8
Blood Eosinophil Count	0.2	1.6	4.5	-0.1	2.1	-0.3
Blood Red Count	0.2	1.7	4.1	-0.7	-0.8	-2.0
BMI	0.2	1.3	2.4	-1.1	1.6	-0.1
Allergy or Eczema	0.2	0.4	1.0	-0.4	-1.0	-0.3
Lung FVC	0.2	1.3	2.3	-1.2	0.0	-1.5
Neuroticism	0.2	0.6	1.3	-0.5	-1.1	0.4
Average weekly spirits intake	0.2	0.3	0.7	0.4	0.1	0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.6	0.0	0.7
Pack years adult smoking proportion	0.2	0.3	0.9	-0.3	-0.3	-0.9
Leg fat-free mass (left)	0.2	0.9	2.5	-1.6	-0.0	0.3
Relative age voice broke	0.2	0.4	0.6	-0.7	0.7	-0.2
High blood pressure	0.2	0.4	1.0	-0.3	-0.4	-1.0
Body mass index (BMI)	0.2	0.9	2.2	-1.5	0.6	0.1
Leg predicted mass (left)	0.2	0.9	2.5	-1.6	-0.0	0.4
Nervous feelings	0.2	0.3	0.6	0.2	0.5	-0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.6	-0.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.5	0.4	0.6
Heart attack	0.2	0.3	0.6	-0.4	0.8	-0.2
Medication: Ramipril	0.2	0.3	0.8	-0.1	0.1	0.9
Illnesses of siblings	0.2	0.2	0.6	-0.1	0.3	0.8
Weight	0.2	1.0	2.0	-1.4	0.6	0.8
Trunk fat-free mass	0.2	1.2	2.5	-1.6	0.1	1.0
Father’s age at death	0.2	0.3	0.5	0.7	-0.5	0.1
Trunk predicted mass	0.2	1.1	2.4	-1.5	0.2	1.0
High blood pressure (siblings)	0.2	0.2	0.5	-0.0	0.7	-0.4
Leg fat percentage (right)	0.2	0.6	0.9	-0.0	0.9	1.0
Number of children fathered	0.2	0.2	0.4	0.1	0.3	0.7
Leg fat mass (right)	0.2	0.6	0.8	-0.8	0.6	0.9
Hypertension (Self-reported)	0.2	0.6	1.1	-0.2	-0.8	-1.1
Smoking status: Previous	0.2	0.3	0.4	-0.6	0.6	-0.1
Whole body fat-free mass	0.2	1.2	3.3	-1.8	-0.0	0.6
Leg fat-free mass (right)	0.2	0.8	2.5	-1.6	-0.1	0.1
Medication for cholesterol	0.2	0.2	0.6	-0.1	0.8	-0.2
Whole body water mass	0.2	1.3	3.4	-1.9	-0.1	0.6
Leg predicted mass (right)	0.2	0.9	2.6	-1.6	-0.1	0.1
Financial situation satisfaction	0.2	0.2	0.3	0.5	-0.3	0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.4	0.6	-0.2
Basal metabolic rate	0.2	1.1	2.8	-1.7	0.2	0.7
Cholesterol lowering medication	0.2	0.4	0.7	-0.0	-0.6	0.8
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	0.0	0.0	0.9
Arm predicted mass (left)	0.2	1.3	2.5	-1.6	0.2	1.1
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	-0.0	-0.2
Worry (Nagel 2018)	0.1	0.1	0.3	-0.6	-0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.2	0.7	-0.4
Smoking Status	0.1	0.3	0.5	0.7	0.3	0.7
Tanning	0.1	1.5	2.1	-1.3	-1.4	0.8
Relative age of first facial hair	0.1	0.2	0.4	-0.5	-0.3	0.7
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.4	-0.0
Trunk fat percentage	0.1	0.3	0.7	-0.0	0.4	0.8
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.0	0.4	-0.4
Maternal smoking around birth	0.1	0.2	0.4	0.6	0.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.0	0.3	0.5
Trunk fat mass	0.1	0.5	1.3	-0.3	0.4	1.2
Number of incorrect matches in round	0.1	0.2	0.6	0.8	0.3	0.1
Past tobacco smoking	0.1	0.1	0.2	0.4	-0.2	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.4	0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	0.2	0.4
Fluid intelligence score	0.1	0.1	0.2	0.4	0.3	0.3
Neuroticism score	0.1	0.3	0.6	0.8	0.3	0.4
Arm fat percentage (right)	0.1	0.3	0.6	0.1	0.8	0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.2	0.0	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	0.0	0.3	1.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.5	0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.4	-0.1	0.6
Arm fat mass (right)	0.1	0.5	0.6	-0.7	0.6	0.7
Standing height	0.1	0.7	2.1	-0.1	0.0	1.5
Birth weight of first child	0.1	0.2	0.4	-0.1	0.2	-0.6
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.6	-0.3	0.8
Gout (self-reported)	0.1	0.1	0.3	-0.4	0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.1	0.1	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.3	-0.6	-0.5	0.1
Body fat percentage	0.1	0.4	0.7	0.2	0.7	0.8
Number of full brothers	0.1	0.1	0.2	0.3	-0.4	0.4
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.1	-0.3	0.5
Mean time to correctly identify matches	0.1	0.1	0.4	-0.6	-0.1	0.1
Whole body fat mass	0.1	0.5	1.1	-0.4	0.5	1.1
Chest pain or discomfort	0.1	0.1	0.2	0.2	-0.2	0.4
Arm fat percentage (left)	0.1	0.3	0.4	-0.2	0.6	0.7
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.5	0.5	0.3
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.1	0.4	-0.6
Medication: Gliclazide	0.1	0.1	0.2	-0.2	0.5	0.1
Arm fat mass (left)	0.1	0.6	1.4	-1.2	0.3	0.6
Medication: Blood pressure	0.1	0.2	0.4	0.6	-0.5	-0.1
Medication: Atorvastatin	0.1	0.1	0.2	0.5	-0.1	0.3
Leg fat percentage (left)	0.1	0.4	0.7	-0.1	0.9	0.7
Unable to work because of sickness or disability	0.1	0.1	0.4	0.1	-0.1	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.5	0.3	0.7	0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	-0.4	0.6	-0.2
Leg fat mass (left)	0.1	0.5	0.7	-0.8	0.6	0.7
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.4	-0.1	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.1	-0.2	0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.9	1.5	0.6	1.2	-1.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.1	-0.4	-0.0
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	0.1	0.1
Sitting height	0.0	0.1	0.2	-0.4	0.5	0.3
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.1	-0.1	0.2
Allergy	0.0	0.0	0.1	0.3	-0.1	0.1
Pulse rate	0.0	0.1	0.1	0.3	0.3	-0.2
Depression (self-reported)	0.0	0.0	0.1	-0.1	0.1	-0.2
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.4	-0.0	-0.1
Comparative height size at age 10	0.0	0.1	0.2	0.1	0.4	0.5
Mineral and other dietary supplements	0.0	0.1	0.1	0.3	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.4	0.2	-0.3
Hearing aid user	0.0	0.0	0.1	-0.3	-0.1	-0.1
Ever smoked	0.0	0.1	0.1	-0.3	-0.1	0.3

Hub : Genes

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Trait associations