Hub : Genes

TYK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.266	0.0858	7.0e-03	0.060	NA	0.065	NA	0.116	3.3e-03	NA	2.3e-03	NA	6.0e-05
2	YFS	Blood	0.127	0.0221	0.0e+00	0.062	0.093	0.095	0.099	0.100	1.7e-19	6.3e-29	1.7e-29	1.6e-30	8.5e-31
3	TCGA	Thyroid Carcinoma	0.110	0.0500	7.1e-05	0.008	0.048	0.023	NA	0.029	5.1e-02	1.9e-05	2.2e-03	NA	7.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	0.9	-0.4	0.4	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.6	1.6	0.1	0.5	-1.2
Depressed Affect (Nagel 2018)	0.7	1.4	1.7	1.1	1.2	1.3
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	-0.0	-0.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.6	1.6	1.1	0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.4	-0.1	0.4
Schizophrenia (2018)	0.4	0.7	1.5	1.2	-0.1	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.4	-0.6	0.5	-1.2
Worry (Nagel 2018)	0.1	0.1	0.3	-0.6	-0.3	-0.1
Alzheimer’s Disease (in mother)	0.8	0.9	1.3	1.1	1.1	0.3
Alzheimer’s Disease (in father)	0.9	1.0	1.6	1.2	-0.7	1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	1.0	0.3	0.5
Crohns Disease (2017)	3.4	7.5	13.2	-2.4	-1.9	-3.6
Irritable Bowel Disease (IBD)	1.6	3.8	10.0	-0.9	-0.8	-3.2
Ulcerative Colitis (UC)	0.6	1.1	1.7	1.2	0.3	-1.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.7	1.3	1.7	-1.3	-0.9	-1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.2	0.7	-0.4
Breast Cancer	0.9	2.1	6.1	-0.5	-2.5	-0.2
Ovarian Cancer	0.5	0.6	0.9	-0.2	-0.9	0.9
Prostate Cancer	1.0	1.4	3.3	-1.8	-0.7	0.5
Age at First Birth	0.0	0.0	0.1	-0.2	0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	-0.5	0.1	-1.1
Coronary Artery Disease (CAD)	0.5	0.6	1.1	-0.8	-1.0	0.0
Crohns Disease (2012)	1.3	2.2	4.7	-1.0	-0.9	-2.2
Mean Putamen Volume	0.4	0.5	0.9	-0.9	-0.4	-0.7
Fasting Glucose	0.3	0.4	0.4	-0.6	-0.6	-0.7
HbA1C	0.8	0.9	2.3	-0.4	-1.5	-0.3
HDL Cholesterol	0.8	1.3	2.2	1.3	0.1	1.5
LDL Cholesterol	1.2	2.0	2.9	1.7	1.1	1.4
Lupus	6.8	10.3	12.9	-3.6	-3.0	-2.9
Neuroticism (2016)	0.6	0.9	2.1	0.3	-1.5	0.7
Primary Biliary Cirrhosis	5.2	7.4	9.4	-2.6	-3.1	-2.4
Rheumatoid Arthritis	3.6	5.0	8.5	-2.3	-2.9	-1.1
Schizophrenia (2014)	0.5	1.1	2.4	1.5	0.5	-0.9
Triglycerides	0.2	0.3	0.6	-0.5	-0.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.5	0.8	0.5
Ulcerative Colitis	0.7	0.9	1.9	1.4	0.8	-0.6
Blood Eosinophil Count	0.2	1.6	4.5	-0.1	2.1	-0.3
Blood Platelet Count	1.7	20.0	21.1	-4.5	-4.3	-4.6
Blood Red Count	0.2	1.7	4.1	-0.7	-0.8	-2.0
Blood White Count	1.6	12.1	16.2	4.0	3.4	3.0
Heel T-Score	0.6	4.5	8.6	-1.6	-2.9	-1.4
BMI	0.2	1.3	2.4	-1.1	1.6	-0.1
Height	0.4	8.6	25.5	0.6	0.1	5.0
Waist Hip Ratio (WHR)	0.3	1.5	2.3	-1.3	-0.8	-1.5
Systolic Blood Pressure	0.4	2.0	5.2	-0.7	-0.6	-2.3
Smoking Status	0.1	0.3	0.5	0.7	0.3	0.7
Allergy or Eczema	0.2	0.4	1.0	-0.4	-1.0	-0.3
Cardiovascular Disease	0.3	0.9	1.3	-0.8	-1.2	-0.9
Hypothyroidism (self reported)	7.4	17.1	28.2	-5.3	-4.3	-2.1
Respiratory disease	0.5	1.1	2.5	1.6	0.9	0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	-0.6	-0.0	-1.4
Lung FEV1/FVC ratio	0.8	4.1	9.1	1.1	1.4	3.0
Lung FVC	0.2	1.3	2.3	-1.2	0.0	-1.5
Neuroticism	0.2	0.6	1.3	-0.5	-1.1	0.4
Chronotype (morning person)	3.6	8.3	13.9	-2.8	-1.8	-3.7
Hair Pigment	0.0	0.9	1.5	0.6	1.2	-1.0
Tanning	0.1	1.5	2.1	-1.3	-1.4	0.8
Hand grip strength (left)	0.8	2.2	5.5	-1.1	0.0	-2.4
Number of treatments/medications taken	1.4	2.5	4.8	-2.2	-1.1	-1.1
Average weekly spirits intake	0.2	0.3	0.7	0.4	0.1	0.8
Sensitivity / hurt feelings	0.4	0.7	1.2	0.9	-0.1	1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	1.0	-0.0	0.7
Hearing difficulty/problems: Yes	0.7	1.0	1.7	1.0	0.6	1.3
Relative age of first facial hair	0.1	0.2	0.4	-0.5	-0.3	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.6	0.0	0.7
Ever used hormone-replacement therapy (HRT)	2.6	3.3	4.9	-2.2	-1.9	-1.2
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	-1.1	0.1	-1.5
Systolic blood pressure, automated reading	0.3	0.8	2.4	0.2	-0.1	-1.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	-0.6	-1.2	-0.6
Angina	1.0	1.4	1.7	-1.3	-1.0	-1.2
Medication for hormone replacement therapy	0.6	0.6	0.9	-0.9	-0.4	-1.0
Vitamin and mineral supplements	0.5	0.7	1.4	-1.2	-0.0	-0.8
Supplements: Zinc	0.7	0.8	2.3	0.3	-0.2	1.5
Medication: Co-codamol	0.4	0.5	1.1	0.2	1.1	0.5
Medication: Metformin	1.6	2.3	6.1	-2.5	0.2	-0.9
Diabetes (father)	0.3	0.3	0.9	-0.3	-1.0	-0.3
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.4	-0.0
Severe depression (siblings)	1.3	1.5	3.8	1.9	0.2	0.7
Pack years adult smoking proportion	0.2	0.3	0.9	-0.3	-0.3	-0.9
Impedance of leg (right)	0.6	2.7	6.0	2.4	0.7	1.3
Leg fat-free mass (left)	0.2	0.9	2.5	-1.6	-0.0	0.3
Trunk fat percentage	0.1	0.3	0.7	-0.0	0.4	0.8
Hand grip strength (right)	1.1	3.0	5.9	-1.8	-0.1	-2.4
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.0	0.4	-0.4
Current tobacco smoking	0.4	0.7	1.3	1.2	-0.0	0.9
Average weekly fortified wine intake	0.6	0.7	1.4	-0.4	-0.7	1.2
Maternal smoking around birth	0.1	0.2	0.4	0.6	0.2	0.5
Fed-up feelings	1.2	2.3	3.5	1.6	0.8	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.4	1.5	0.1	0.8
Relative age voice broke	0.2	0.4	0.6	-0.7	0.7	-0.2
Taking other prescription medications	0.3	0.5	0.9	-0.9	-0.8	0.4
Age when periods started (menarche)	0.6	1.6	2.7	1.4	1.6	0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.3	-1.0	0.2	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.9	-0.6	-0.3	-1.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.6	-0.7	0.5	-2.1
Qualifications: CSEs or equivalent	0.5	0.6	1.5	-0.7	-0.2	1.2
Serious illness, injury or assault to yourself	1.0	1.2	2.0	0.8	1.0	1.4
High blood pressure	0.2	0.4	1.0	-0.3	-0.4	-1.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.1	-0.4	-0.0
Multivitamins +/- minerals	1.3	1.7	2.7	1.5	0.6	1.6
Stomach or abdominal pain in last month	2.4	3.0	5.3	1.2	2.3	1.5
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.0	0.3	0.5
Medication: Atenolol	0.5	0.6	1.3	-0.2	-0.7	-1.1
Medication: Levothyroxine sodium	3.8	6.4	9.1	-3.0	-2.6	-1.8
Sitting height	0.0	0.1	0.2	-0.4	0.5	0.3
Chronic bronchitis/emphysema (father)	2.9	3.4	7.8	2.8	0.2	1.5
High blood pressure (mother)	0.8	1.1	2.1	0.8	-0.7	1.4
Body mass index (BMI)	0.2	0.9	2.2	-1.5	0.6	0.1
Impedance of leg (left)	0.4	2.0	4.8	2.2	0.6	0.8
Leg predicted mass (left)	0.2	0.9	2.5	-1.6	-0.0	0.4
Trunk fat mass	0.1	0.5	1.3	-0.3	0.4	1.2
Waist circumference	0.3	1.0	1.7	-1.3	0.9	0.7
Number of incorrect matches in round	0.1	0.2	0.6	0.8	0.3	0.1
Past tobacco smoking	0.1	0.1	0.2	0.4	-0.2	-0.4
Alcohol usually taken with meals	1.1	1.7	2.7	-1.6	-1.6	0.3
Nervous feelings	0.2	0.3	0.6	0.2	0.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.1	1.8	0.7	1.1
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.4	0.4	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.6	-0.1	0.8
Had menopause	1.0	1.2	2.5	-1.6	-0.4	-1.0
Had other major operations	1.7	2.0	3.2	1.8	1.4	0.9
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.1	-0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	6.0	-1.8	-1.4	-2.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.5	0.4	0.6
Qualifications: None of the above	0.6	1.2	2.9	-0.6	-0.6	-1.7
Financial difficulties in last 2 years	1.5	2.0	4.9	0.9	-0.5	2.2
Mouth/teeth dental problems	1.0	1.5	2.3	-1.3	0.8	-1.5
Heart attack	0.2	0.3	0.6	-0.4	0.8	-0.2
Allergy	0.0	0.0	0.1	0.3	-0.1	0.1
Pain all over the body in last month	0.3	0.3	0.8	-0.2	0.4	-0.9
Diabetes (self-reported)	0.3	0.5	1.3	-1.1	0.0	-0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	0.2	0.4
Medication: Ramipril	0.2	0.3	0.8	-0.1	0.1	0.9
Medication: Simvastatin	0.7	1.0	1.9	-1.4	-0.6	-0.8
Fluid intelligence score	0.1	0.1	0.2	0.4	0.3	0.3
Illnesses of siblings	0.2	0.2	0.6	-0.1	0.3	0.8
Neuroticism score	0.1	0.3	0.6	0.8	0.3	0.4
Weight	0.2	1.0	2.0	-1.4	0.6	0.8
Impedance of arm (right)	0.5	2.6	7.3	2.7	0.5	0.4
Arm fat percentage (right)	0.1	0.3	0.6	0.1	0.8	0.6
Trunk fat-free mass	0.2	1.2	2.5	-1.6	0.1	1.0
Hip circumference	0.3	1.2	1.8	-0.9	1.4	1.1
Time employed in main current job	0.5	0.6	1.0	-0.3	1.0	-0.9
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.2	0.0	-0.5
Father’s age at death	0.2	0.3	0.5	0.7	-0.5	0.1
Worrier / anxious feelings	1.1	2.0	4.1	0.9	-2.0	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.0	0.2	1.4	-0.9
Falls in the last year	0.6	0.9	2.5	0.3	1.6	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-1.0	-0.8	-0.2
Number of live births	3.2	4.5	5.4	2.1	-1.9	2.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	0.0	0.3	1.1
Pulse rate	0.0	0.1	0.1	0.3	0.3	-0.2
Happiness	0.8	0.9	2.3	-0.3	0.6	-1.5
Noisy workplace	1.2	1.5	3.1	1.8	1.0	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.5	0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	5.2	2.0	0.8	2.3
Mouth/teeth dental problems: Dentures	1.3	2.2	3.6	-1.9	-1.7	-0.1
Asthma	0.6	1.3	2.7	1.6	0.7	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.3	-0.0	1.1
Medication: Cholesterol lowering	0.6	0.9	1.4	-1.1	-0.3	-1.2
Depression (self-reported)	0.0	0.0	0.1	-0.1	0.1	-0.2
Medication: Lansoprazole	2.0	2.3	4.4	-0.1	-2.1	1.6
Prospective memory result	2.2	2.7	3.3	-1.8	-1.6	-1.6
Lung cancer (father)	0.5	0.5	0.8	-0.2	0.9	-0.8
Illnesses of mother	1.7	2.1	4.7	-1.0	0.7	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	-0.4	-0.1	0.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	-0.2	-1.3	0.7
Impedance of arm (left)	0.4	1.7	4.8	2.2	0.1	0.4
Arm fat mass (right)	0.1	0.5	0.6	-0.7	0.6	0.7
Trunk predicted mass	0.2	1.1	2.4	-1.5	0.2	1.0
Standing height	0.1	0.7	2.1	-0.1	0.0	1.5
Length of working week for main job	0.5	0.5	1.1	-1.0	0.3	-0.6
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.4	-0.0	-0.1
Breastfed as a baby	1.2	1.5	2.6	-1.6	-1.2	-0.8
Tense / ‘highly strung’	0.7	1.1	1.9	-1.4	-0.6	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.7	1.6	0.9	1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.1	0.3	1.1	-1.0
Birth weight of first child	0.1	0.2	0.4	-0.1	0.2	-0.6
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.6	-0.3	0.8
Pulse wave reflection index	0.6	0.7	1.6	-0.1	-0.7	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.4	-1.3	-0.3
Loud music exposure frequency	0.5	0.5	1.3	-1.1	-0.5	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	3.0	0.1	0.4	1.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.5	0.9	1.9	0.2
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.3	-0.6	-1.0
Medication: Paracetamol	0.9	1.5	1.6	-1.2	-1.2	1.2
Headache pain in last month	0.4	0.7	1.5	-0.7	-1.2	0.0
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	5.6	2.2	0.7	2.4
Glaucoma (self-reported)	1.3	1.5	4.3	0.1	2.1	-0.3
Gout (self-reported)	0.1	0.1	0.3	-0.4	0.1	-0.5
Hypothyroidism/myxoedema (self-reported)	5.0	9.7	14.8	-3.9	-3.6	-1.2
Medication: Amlodipine	0.6	0.9	1.8	-1.0	-1.3	0.0
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.2	1.5	0.4	-0.4
Birth weight	0.6	1.4	1.7	-1.3	-1.3	0.8
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	-0.1	0.1	-0.6
High blood pressure (siblings)	0.2	0.2	0.5	-0.0	0.7	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.2	0.3	-0.6	-0.5	0.1
Body fat percentage	0.1	0.4	0.7	0.2	0.7	0.8
Leg fat percentage (right)	0.2	0.6	0.9	-0.0	0.9	1.0
Arm fat-free mass (right)	0.4	1.8	4.8	-2.2	-0.2	0.8
Exposure to tobacco smoke outside home	0.3	0.4	1.3	-0.2	-1.1	-0.0
Comparative body size at age 10	0.5	1.3	2.9	1.7	0.6	0.7
Number of full brothers	0.1	0.1	0.2	0.3	-0.4	0.4
Worry too long after embarrassment	0.8	1.4	2.1	-1.3	-0.6	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	0.6	1.2	0.2
Wheeze or whistling in the chest in last year	1.2	2.2	4.8	1.3	-0.2	2.2
Number of children fathered	0.2	0.2	0.4	0.1	0.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.8	-0.8	-0.2	-1.7
Age at first live birth	0.5	0.8	2.2	0.2	0.5	-1.5
Pulse wave peak to peak time	0.7	0.8	2.0	0.2	1.4	-0.6
Health satisfaction	2.3	2.9	5.2	-1.7	-0.8	-2.3
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.1	-0.3	0.5
Qualifications: College or University degree	1.1	3.5	5.3	-2.3	-0.7	-2.2
Eye problems/disorders: None of the above	1.0	1.1	2.4	0.8	1.6	-0.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.7	1.6	-0.0	1.6
Emphysema/chronic bronchitis	0.6	0.7	1.2	-1.1	-0.7	-0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	4.1	1.0	1.2	-2.0
Neck or shoulder pain in last month	1.0	1.4	2.4	1.3	0.5	1.6
Medication: Blood pressure	2.5	4.4	7.5	-2.7	-1.7	-1.7
Angina (self-reported)	1.0	1.3	1.8	-1.3	-0.8	-1.2
Migraine (self-reported)	0.3	0.4	0.7	-0.8	-0.5	-0.5
Medication: Ibuprofen	0.4	0.5	1.2	-1.1	-0.3	0.3
Medication: Allopurinol	0.6	0.9	1.3	-0.9	-0.6	-1.2
Medication: Omeprazole	0.8	1.0	2.6	-1.6	-0.0	-0.5
Medication: Seretide 50 evohaler	2.7	3.1	8.4	2.9	0.6	0.7
Mean time to correctly identify matches	0.1	0.1	0.4	-0.6	-0.1	0.1
Heart disease (mother)	0.3	0.4	0.6	0.6	0.1	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.2	-0.9	-0.4
Whole body fat mass	0.1	0.5	1.1	-0.4	0.5	1.1
Leg fat mass (right)	0.2	0.6	0.8	-0.8	0.6	0.9
Arm predicted mass (right)	0.3	1.3	3.4	-1.9	-0.1	0.8
Pulse rate, automated reading	0.6	1.9	2.4	1.4	1.2	1.5
Alcohol intake frequency.	0.7	1.5	2.3	-0.8	-1.3	-1.5
Comparative height size at age 10	0.0	0.1	0.2	0.1	0.4	0.5
Number of full sisters	2.8	3.4	6.8	-2.6	-1.3	-1.3
Suffer from ‘nerves’	0.6	0.9	2.1	0.6	1.5	-0.3
Overall health rating	0.4	0.9	2.6	0.4	1.6	-0.3
Chest pain or discomfort	0.1	0.1	0.2	0.2	-0.2	0.4
Had major operations	0.8	1.0	2.2	0.4	-0.7	1.5
Age at last live birth	0.3	0.5	0.9	0.9	-0.7	0.1
Family relationship satisfaction	0.4	0.5	1.1	1.0	0.2	0.5
Leg pain on walking	0.4	0.5	1.1	-0.1	-0.6	-1.1
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.1	5.6	1.3	1.3	2.4
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.5	1.3	1.9	-0.0
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	3.5	-1.4	-1.2	-1.9
Medication: Aspirin	1.1	1.5	2.7	-1.4	-1.6	-0.0
Supplements: Vitamin C	0.4	0.5	0.7	0.4	-0.8	-0.8
Knee pain experienced in last month	2.2	3.4	6.5	1.7	1.0	2.5
Hypertension (Self-reported)	0.2	0.6	1.1	-0.2	-0.8	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	-0.3	0.8	0.8
Illnesses of father: Heart disease	0.7	0.9	1.6	-1.1	-1.3	-0.2
Illnesses of siblings: Diabetes	1.4	1.7	2.5	0.5	-1.5	-1.6
Smoking status: Previous	0.2	0.3	0.4	-0.6	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	0.7	1.3	0.4
Whole body fat-free mass	0.2	1.2	3.3	-1.8	-0.0	0.6
Leg fat-free mass (right)	0.2	0.8	2.5	-1.6	-0.1	0.1
Arm fat percentage (left)	0.1	0.3	0.4	-0.2	0.6	0.7
Average weekly red wine intake	0.6	0.9	2.6	0.1	0.1	1.6
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.6	1.4	0.1	1.6
Mood swings	1.1	1.9	2.2	1.5	1.2	1.5
Loneliness, isolation	2.0	2.7	3.8	1.4	2.0	1.5
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.4	0.5	-1.2
Ever had bowel cancer screening	1.8	2.1	3.6	0.6	-1.9	1.6
Diabetes diagnosed by doctor	0.3	0.5	0.9	-1.0	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.8	2.0	4.4	1.2	0.3	2.1
Friendships satisfaction	1.4	1.7	2.5	1.6	1.5	0.6
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.5	0.5	0.3
Commuting to job workplace: Walk	0.9	0.9	1.7	-1.0	-1.3	0.3
Eye problems/disorders: Cataract	1.3	1.5	2.4	-1.6	-1.5	0.1
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	6.0	2.5	0.6	2.3
Medication for cholesterol	0.2	0.2	0.6	-0.1	0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.4	0.5	-1.8	0.8
Back pain experienced in last month	0.7	1.0	1.9	0.8	1.4	0.5
Mineral and other dietary supplements	0.0	0.1	0.1	0.3	-0.1	-0.2
Breast cancer (self-reported)	2.6	3.1	8.2	0.5	2.9	-1.0
Asthma (self-reported)	0.4	0.7	1.7	1.3	0.6	0.4
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.1	0.4	-0.6
Osteoarthritis (self-reported)	3.7	4.7	10.2	2.0	-0.1	3.2
Medication: Aspirin	0.9	1.2	2.5	-0.9	-1.6	0.7
Medication: Gliclazide	0.1	0.1	0.2	-0.2	0.5	0.1
Illnesses of father: None of the above (group 1)	1.5	1.9	4.1	0.6	2.0	1.1
Smoking status: Current	0.5	0.8	1.7	1.3	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.4	0.2	-0.3
Whole body water mass	0.2	1.3	3.4	-1.9	-0.1	0.6
Leg predicted mass (right)	0.2	0.9	2.6	-1.6	-0.1	0.1
Arm fat mass (left)	0.1	0.6	1.4	-1.2	0.3	0.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	-0.7	-1.3	-0.3
Average weekly champagne plus white wine intake	1.5	2.1	2.7	-1.6	-1.2	-1.5
Miserableness	1.8	3.2	5.3	2.3	1.6	1.4
Guilty feelings	0.8	1.2	1.7	-0.7	-1.3	-1.2
Wears glasses or contact lenses	0.7	0.8	1.4	-1.0	-0.5	1.2
Ever taken oral contraceptive pill	1.4	1.6	4.7	2.2	0.4	0.2
Hearing aid user	0.0	0.0	0.1	-0.3	-0.1	-0.1
Mother’s age at death	1.4	1.8	2.2	1.5	1.2	1.4
Financial situation satisfaction	0.2	0.2	0.3	0.5	-0.3	0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.4	-0.8	-1.2	0.6
Commuting to job workplace: Public transport	0.6	0.7	1.2	-0.4	-1.1	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.4	0.6	-0.2
Medication: Blood pressure	0.1	0.2	0.4	0.6	-0.5	-0.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.2	2.0	1.7	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.0	-0.1	-0.2	1.0
High cholesterol (Self-reported)	0.3	0.6	1.3	-0.5	-0.5	-1.1
Medication: Bendroflumethiazide	0.5	0.7	1.6	0.3	-0.7	-1.2
Medication: Paracetamol	1.0	1.6	1.8	-1.2	-1.2	1.4
Medication: Lisinopril	2.8	3.7	8.0	-1.6	-0.7	-2.8
Medication: Atorvastatin	0.1	0.1	0.2	0.5	-0.1	0.3
Illnesses of father: High blood pressure	1.6	1.9	4.7	-1.0	0.0	-2.2
Alcohol drinker status: Never	1.0	1.3	1.7	-1.3	-0.6	-1.3
Ever smoked	0.0	0.1	0.1	-0.3	-0.1	0.3
Basal metabolic rate	0.2	1.1	2.8	-1.7	0.2	0.7
Leg fat percentage (left)	0.1	0.4	0.7	-0.1	0.9	0.7
Arm fat-free mass (left)	0.3	1.5	3.6	-1.9	-0.0	0.9
Number of operations (self-reported)	1.4	2.1	3.3	1.5	1.0	1.8
Average weekly beer plus cider intake	1.5	2.2	4.3	-1.1	1.1	-2.1
Irritability	1.4	2.3	5.6	1.2	-0.0	2.4
Risk taking	0.5	0.7	1.6	-1.3	-0.1	-0.8
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.2	0.6	-1.5	1.3
Fractured/broken bones in last 5 years	1.9	2.4	3.6	1.5	1.1	1.9
Age started oral contraceptive pill	0.5	0.6	1.2	0.2	-1.1	-0.8
Diastolic blood pressure, automated reading	0.9	2.7	4.3	-1.9	0.2	-2.1
Ever depressed for a whole week	1.7	2.1	3.2	1.5	0.8	1.8
Unable to work because of sickness or disability	0.1	0.1	0.4	0.1	-0.1	0.6
Commuting to job workplace: Cycle	1.6	1.9	3.3	-1.5	-0.4	-1.8
Myopia	0.7	1.0	2.0	-1.4	-0.8	-0.6
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.5	0.3	0.7	0.7
Cholesterol lowering medication	0.2	0.4	0.7	-0.0	-0.6	0.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	4.6	-2.2	-0.4	0.6
Pain experienced in last month	0.8	1.3	2.3	-0.8	-1.0	-1.5
Supplements: Calcium	1.4	1.6	3.7	-0.9	0.4	-1.9
Basal cell carcinoma (self-reported)	0.2	0.3	0.8	0.0	0.0	0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	-0.4	0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.1	-0.7	-0.7
Heart disease (siblings)	1.8	2.2	5.2	-0.9	-0.7	-2.3
Alcohol drinker status: Previous	0.9	1.0	1.6	0.2	-1.2	-1.3
Pack years of smoking	0.6	0.8	1.4	-0.8	-0.7	-1.2
Impedance of whole body	0.3	1.5	4.2	2.1	-0.0	0.5
Leg fat mass (left)	0.1	0.5	0.7	-0.8	0.6	0.7
Arm predicted mass (left)	0.2	1.3	2.5	-1.6	0.2	1.1