TWAS hub - U2SURP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0950	0.0260	2.0e-07	0.079	0.057	0.055	0.059	0.067	7.8e-10	1.8e-07	2.7e-07	1.0e-07	1.3e-08
2	GTEx	Adipose Subcutaneous	0.1080	0.0460	8.2e-03	0.004	NA	-0.003	NA	0.000	1.4e-01	NA	9.9e-01	NA	3.0e-01
3	GTEx	Brain Hypothalamus	0.4550	0.1220	2.2e-03	-0.004	NA	0.017	NA	0.037	4.0e-01	NA	1.3e-01	NA	4.9e-02
4	GTEx	Skin Sun Exposed Lower leg	0.0980	0.0350	4.1e-04	0.058	NA	0.032	NA	0.044	1.5e-05	NA	1.1e-03	NA	1.5e-04
5	GTEx	Small Intestine Terminal Ileum	0.2980	0.1000	4.4e-03	0.048	NA	0.052	NA	0.061	3.2e-02	NA	2.7e-02	NA	1.8e-02
6	METSIM	Adipose	0.0447	0.0196	1.5e-03	0.023	0.008	0.007	0.011	0.012	1.9e-04	1.8e-02	2.5e-02	6.4e-03	5.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Family relationship satisfaction	6.7	8.2	12.9	-3.2	-3.2	2.3	-3.6	-0.8	-3.2
Past tobacco smoking	6.1	11.3	15.8	3.8	3.4	-3.4	4.0	1.2	3.6
Ever smoked	5.9	10.3	15.1	-3.8	-3.3	2.6	-3.9	-1.7	-3.5
Happiness	5.2	6.3	10.6	-3.0	-3.3	0.3	-3.1	0.7	-2.9
Smoking status: Previous	4.8	7.2	10.4	-2.9	-2.6	3.2	-3.1	-0.5	-2.8
Birth weight of first child	4.6	8.4	10.5	-2.7	-3.2	2.4	-3.2	-3.1	-2.6
Hand grip strength (left)	4.4	11.6	21.8	-4.0	-4.7	0.5	-4.0	0.2	-3.8
Birth weight	4.2	9.1	15.4	-3.5	-3.4	1.5	-3.6	-0.3	-3.9
Severe depression (siblings)	4.1	4.6	6.8	-2.5	-2.6	1.2	-2.6	-0.8	-2.5
Sensitivity / hurt feelings	3.4	5.8	9.0	-2.7	-2.7	1.9	-3.0	-0.9	-2.7
Depression (self-reported)	3.4	4.1	5.7	-2.3	-2.4	0.2	-2.4	1.7	-2.2
Waist Hip Ratio (WHR)	3.3	14.6	24.2	-4.7	-4.5	-0.5	-4.9	-0.3	-4.5
Smoking Status	3.3	8.0	11.1	-2.8	-2.7	2.9	-3.1	-2.0	-3.3
Hand grip strength (right)	3.3	9.1	14.3	-3.6	-3.8	0.1	-3.7	-0.5	-3.5
Loud music exposure frequency	3.2	3.5	5.2	-2.0	-2.3	1.6	-2.3	-1.2	-1.6
Lung FEV1/FVC ratio	3.1	15.7	27.2	4.6	4.3	-0.2	5.2	-0.3	5.2
Major Depression (MDD)	2.9	3.5	6.9	-1.6	-2.6	1.6	-2.0	1.3	-1.9
Body Mass Index (BMI) (2010)	2.9	3.9	8.4	2.9	2.2	0.4	2.3	-1.0	1.9
Eye problems/disorders: None of the above	2.9	3.3	5.2	1.9	2.3	-1.5	2.2	0.7	1.8
Osteoporosis (self-reported)	2.8	3.5	5.2	-2.0	-1.9	1.3	-2.3	-1.6	-2.1
Wears glasses or contact lenses	2.7	3.2	4.9	2.0	1.5	0.1	1.8	2.2	2.1
Friendships satisfaction	2.6	3.2	5.2	-2.2	-2.1	0.2	-2.3	-0.2	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	5.7	1.7	1.4	0.7	2.0	-1.0	2.4
Alcohol drinker status: Never	2.4	2.8	5.9	2.1	1.7	0.2	2.4	-0.3	1.9
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.8	2.2	1.2	0.5	2.2	-0.9	2.1
Eye problems/disorders: Cataract	2.3	2.7	4.3	-1.3	-1.9	2.1	-2.1	0.0	-1.6
Irritability	2.3	3.9	7.5	-1.9	-2.7	0.0	-2.4	1.1	-2.2
Systolic blood pressure, automated reading	2.1	6.2	11.1	2.8	3.0	0.5	3.3	0.4	3.0
Exposure to tobacco smoke at home	2.1	2.4	4.8	1.6	1.6	1.2	1.7	-0.2	2.2
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	3.5	1.9	1.8	0.8	1.7	-1.6	1.9
Neuroticism	2.0	4.9	11.1	-2.2	-3.3	1.3	-2.5	1.1	-2.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.2	-1.2	-2.1	1.7	-1.7	-0.4	-1.5
Neuroticism (Nagel 2018)	1.9	4.5	8.7	-2.0	-2.9	0.2	-2.6	1.7	-2.3
Prostate Cancer	1.9	2.6	5.6	-1.8	-2.4	0.8	-1.7	0.0	-1.8
Ever had bowel cancer screening	1.9	2.2	3.6	-1.5	-1.7	0.4	-1.9	-1.4	-1.6
Reaction Time	1.8	3.5	5.3	-2.1	-2.2	-1.5	-2.3	0.7	-2.0
Verbal and Numeric Reasoning (VNR)	1.8	4.3	7.5	2.5	2.6	-0.7	2.7	1.0	2.1
Bipolar Disorder (2011)	1.8	1.7	7.3	0.7	0.3	2.7	0.7	-0.5	1.2
Chronic bronchitis/emphysema (father)	1.8	2.1	3.4	-1.8	-1.4	-1.2	-1.7	0.4	-1.6
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.3	-1.4	-1.7	1.1	-2.1	-0.6	-1.4
Alcohol intake frequency.	1.8	4.1	6.8	2.3	1.6	-1.6	2.2	2.6	1.6
Commuting to job workplace: Public transport	1.8	2.2	4.0	1.4	1.8	0.1	1.9	-0.5	2.0
Average weekly beer plus cider intake	1.8	2.6	5.1	-1.7	-1.2	2.2	-1.1	-2.0	-1.0
Neuroticism (2016)	1.7	2.4	6.2	-1.6	-2.5	0.7	-1.7	0.5	-1.4
Alcohol intake versus 10 years previously	1.7	2.5	6.8	0.9	1.5	-1.7	1.2	2.6	0.9
Gout (self-reported)	1.7	2.3	3.7	1.7	1.8	0.3	1.7	-0.9	1.9
Long-standing illness, disability or infirmity	1.7	2.6	5.4	1.6	1.4	1.4	1.9	-0.1	2.3
Medication: Lisinopril	1.7	2.2	3.5	-1.9	-1.7	-0.2	-1.7	0.9	-1.7
Myopia	1.7	2.4	4.3	1.9	1.7	-0.4	1.8	-0.1	2.1
Supplements: Calcium	1.7	1.9	3.0	-1.7	-1.5	1.4	-1.6	-0.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	7.5	-1.0	-1.1	0.3	-1.0	-2.7	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.0	-0.9	-1.8	-0.5	-1.8	2.0	-1.2
Father’s age at death	1.6	2.2	2.6	1.6	1.6	-1.4	1.5	1.2	1.6
Prospective memory result	1.6	2.0	4.0	-1.7	-2.0	0.9	-1.7	-0.2	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.6	-1.6	-1.2	0.2	-1.9	0.4	-1.8
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.4	-1.3	-1.4	0.4	-1.7	0.9	-1.8
Loneliness, isolation	1.6	2.2	4.2	-1.2	-1.4	1.2	-1.5	2.0	-1.2
HbA1C	1.5	1.7	3.3	-1.3	-1.0	-1.0	-1.7	-0.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.2	5.4	-2.0	-2.1	0.1	-2.0	-0.9	-2.3
Average weekly red wine intake	1.5	2.2	4.0	-1.2	-1.6	2.0	-1.4	-1.6	-1.1
Commuting to job workplace: Walk	1.5	1.6	2.2	0.7	1.5	-1.5	1.0	1.3	1.4
Intelligence (Savage-Jansen 2018)	1.4	4.2	5.5	2.1	2.3	-1.9	2.3	1.5	2.1
Alzheimer’s Disease (in father)	1.4	1.5	2.7	-1.4	-1.3	0.6	-1.3	0.6	-1.6
Had menopause	1.4	1.7	2.9	-1.3	-1.7	1.4	-1.4	-0.8	-1.1
Had other major operations	1.4	1.8	4.7	0.4	1.2	-1.7	1.0	2.2	0.7
Number of live births	1.4	2.0	7.1	-0.3	-1.3	2.7	-0.9	-0.7	-1.2
Depressed Affect (Nagel 2018)	1.3	2.7	5.1	-1.7	-2.3	0.6	-1.8	1.6	-1.5
Primary Biliary Cirrhosis	1.3	1.8	2.7	1.0	1.2	-1.6	1.3	1.6	1.3
Heel T-Score	1.3	10.1	14.7	3.6	3.8	-2.4	3.8	1.4	3.3
Average weekly spirits intake	1.3	1.6	3.8	0.7	1.1	-2.0	1.2	1.2	1.0
Diabetes (father)	1.3	1.6	2.2	-1.2	-1.4	1.1	-1.3	-1.5	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	5.1	2.0	2.3	-0.3	2.2	-0.7	1.9
Worrier / anxious feelings	1.3	2.4	3.5	-1.8	-1.8	-0.6	-1.9	1.2	-1.5
Pulse rate	1.3	2.2	3.8	0.8	1.8	-1.1	1.4	1.9	1.5
Lung cancer (father)	1.3	1.5	2.9	-1.4	-1.4	-0.2	-1.5	0.4	-1.7
Neck or shoulder pain in last month	1.3	1.9	2.7	1.4	1.4	-0.3	1.5	1.5	1.7
Knee pain experienced in last month	1.3	2.1	3.6	1.6	1.0	-1.3	1.5	1.9	1.2
Neuroticism score	1.2	2.6	3.8	-1.7	-1.8	1.0	-2.0	1.3	-1.7
Worry too long after embarrassment	1.2	2.0	3.3	-1.5	-1.6	1.0	-1.8	1.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.5	-0.8	-1.0	-2.4	-0.6	0.9	-0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.5	-1.4	-1.6	0.6	-1.2	0.6	-1.2
Qualifications: CSEs or equivalent	1.1	1.4	4.9	0.8	-0.2	2.2	0.5	-1.5	0.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.6	0.9	1.4	-0.8	1.3	-1.2	1.6
Medication: Cholesterol lowering	1.1	1.7	3.8	-1.0	-0.8	2.0	-1.3	1.4	-1.0
Blood clot in the leg (DVT)	1.1	1.4	6.8	-0.5	-0.6	0.3	-0.4	-2.6	-1.0
Leg fat percentage (right)	1.1	4.2	6.1	2.4	1.6	1.2	2.5	2.0	2.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.1	0.6	1.8	-1.4	1.3	-0.2	0.9
Medication: Aspirin	1.1	1.4	2.2	-1.5	-0.9	0.3	-1.4	1.2	-1.5
Medication: Gliclazide	1.1	1.2	1.9	1.1	1.0	0.2	1.2	1.4	1.4
Townsend deprivation index at recruitment	1.0	1.4	3.5	0.5	1.4	-1.9	1.2	0.4	1.1
Heart attack	1.0	1.3	5.9	-0.6	-0.5	-0.2	-0.9	2.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.8	-1.5	-1.4	0.3	-1.7	1.1	-1.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.3	-1.2	-1.8	-0.4	-1.2	0.1	-0.9
Number of children fathered	1.0	1.2	3.6	0.0	-0.7	-1.7	-0.0	1.9	-0.3
Comparative height size at age 10	1.0	5.6	9.0	-2.7	-3.0	0.1	-2.8	-1.1	-2.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.6	1.4	0.8	-0.0	1.4	-0.3	1.6
Illnesses of father: Heart disease	1.0	1.5	3.1	1.4	1.3	1.8	1.0	0.2	1.0
Triglycerides	0.9	1.5	2.3	1.5	1.3	-0.7	1.2	1.4	1.2
Qualifications: None of the above	0.9	2.0	6.6	0.5	1.4	0.1	1.2	2.6	1.2
Mouth/teeth dental problems	0.9	1.3	2.1	-0.7	-1.5	-0.9	-1.1	-1.4	-1.1
Medication: Amlodipine	0.9	1.3	3.3	-1.8	-1.0	-0.8	-1.2	0.2	-1.1
Comparative body size at age 10	0.9	2.6	3.9	-1.5	-2.0	1.1	-1.8	1.0	-2.0
Qualifications: College or University degree	0.9	2.8	5.5	-1.6	-1.8	-0.1	-2.2	-0.8	-2.3
Mean time to correctly identify matches	0.9	1.8	2.5	-1.2	-1.3	-1.6	-1.5	1.0	-1.3
Suffer from ‘nerves’	0.9	1.4	2.0	-1.1	-1.4	1.3	-1.3	0.2	-1.2
Illnesses of siblings: Diabetes	0.9	1.1	1.7	-1.2	-0.7	1.3	-1.1	-1.0	-0.9
Diabetes diagnosed by doctor	0.9	1.5	2.9	-0.9	-1.4	1.7	-1.3	0.0	-1.2
Pain experienced in last month	0.9	1.4	3.3	-1.5	-0.4	-0.3	-1.2	-1.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	4.9	-0.6	-0.6	0.2	-0.9	2.2	-0.7
Depression (Nagel 2018)	0.8	1.1	3.4	-0.8	-1.1	0.2	-1.2	1.8	-0.6
Worry (Nagel 2018)	0.8	1.7	3.8	-1.4	-1.9	-0.0	-1.6	1.0	-1.1
Age at First Birth	0.8	1.1	2.8	-1.7	-1.0	0.1	-1.3	-0.3	-1.1
HDL Cholesterol	0.8	1.3	2.6	-1.0	-1.6	0.3	-1.3	-0.2	-1.6
Medication for hormone replacement therapy	0.8	0.9	1.8	-0.7	-1.2	1.2	-0.5	-1.3	-0.4
Pack years adult smoking proportion	0.8	1.2	1.8	-1.3	-0.9	1.3	-1.1	-0.3	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.8	1.7	1.6	-0.5	1.7	-0.2	1.5
Fluid intelligence score	0.8	1.6	2.7	1.4	1.5	-0.6	1.6	0.7	1.4
Length of working week for main job	0.8	0.8	3.9	-0.0	-0.0	-2.0	0.3	-0.9	0.4
Mouth/teeth dental problems: Loose teeth	0.8	1.0	4.0	1.0	0.4	2.0	0.4	0.0	0.5
Miserableness	0.8	1.4	2.4	-0.8	-1.5	0.5	-1.2	1.2	-1.6
Leg fat percentage (left)	0.8	2.8	3.4	1.8	1.1	1.6	1.9	1.8	1.8
Fractured/broken bones in last 5 years	0.8	1.0	1.4	-1.2	-1.2	0.8	-0.9	-1.0	-0.9
Diastolic blood pressure, automated reading	0.8	2.4	5.7	1.5	1.9	0.5	2.4	0.1	1.6
Bipolar Disorder (2018)	0.7	1.2	5.2	-0.3	-0.5	2.3	-0.7	0.8	-0.5
Coronary Artery Disease (CAD)	0.7	0.8	1.4	0.7	1.2	-0.7	0.9	-1.1	0.8
Blood Eosinophil Count	0.7	5.7	9.5	-3.1	-2.7	0.1	-2.8	-1.7	-2.6
Blood Red Count	0.7	6.6	8.9	-2.7	-3.0	1.8	-3.0	1.9	-2.8
Maternal smoking around birth	0.7	1.0	2.0	-0.8	-0.6	1.4	-1.1	-0.4	-1.2
Number of incorrect matches in round	0.7	1.1	1.9	-1.4	-1.4	-1.1	-1.0	0.6	-0.6
Alcohol usually taken with meals	0.7	1.1	1.5	1.0	1.2	-0.0	1.2	-1.2	1.0
Diabetes (self-reported)	0.7	1.1	4.8	-0.3	-0.8	2.2	-0.8	-0.6	-0.5
Medication: Ibuprofen	0.7	0.8	2.5	0.2	0.6	-1.6	0.3	-1.0	0.9
Medication: Aspirin	0.7	0.9	1.5	-1.2	-0.8	0.4	-1.1	0.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.5	1.5	1.1	-1.4	1.6	-0.2	1.1
Leg predicted mass (right)	0.7	3.7	6.2	-2.0	-2.5	1.0	-2.0	-1.8	-1.8
Number of operations (self-reported)	0.7	1.0	2.5	-1.0	-1.2	0.6	-0.4	1.6	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.6	-0.7	-1.6	0.4	-1.0	0.3	-0.7
Ever depressed for a whole week	0.7	0.8	2.2	-0.6	-0.1	1.2	-0.8	-1.5	-0.6
LDL Cholesterol	0.6	1.0	1.7	-0.9	-1.2	-0.6	-1.1	0.7	-1.3
Blood White Count	0.6	4.5	7.3	-2.7	-1.9	-0.3	-2.5	-2.0	-2.3
Frequency of depressed mood in last 2 weeks	0.6	0.9	4.6	0.4	-0.1	0.0	0.3	2.1	0.7
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	-0.3	-0.9	1.2	0.1	-1.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.0	-0.6	-0.8	1.4	-0.7	0.7	-0.5
Supplements: Zinc	0.6	0.6	3.1	-0.3	-0.0	1.8	0.0	-0.7	0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	0.3	1.5	0.8	1.0	0.0	0.4
Medication: Atenolol	0.6	0.7	3.4	0.2	-0.3	-0.9	0.0	1.8	-0.0
Nervous feelings	0.6	1.1	5.2	0.6	0.3	-0.1	0.5	2.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	4.0	-0.1	-0.6	-0.8	-0.4	2.0	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.8	-0.0	0.1	-1.2	-0.2	1.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	0.5	0.9	-0.9	0.6	-1.1	1.1
Medication: Lansoprazole	0.6	0.6	1.1	0.9	0.3	1.0	0.6	1.1	0.7
Standing height	0.6	6.4	10.4	-2.8	-2.7	0.0	-2.9	-2.0	-3.2
Breastfed as a baby	0.6	0.8	2.0	-0.4	-0.9	1.4	-0.6	-1.1	-0.5
Peak expiratory flow (PEF)	0.6	1.4	3.1	-0.9	-1.5	-1.8	-0.9	-0.3	-1.3
Forced vital capacity (FVC), Best measure	0.6	2.2	3.3	-1.8	-1.3	0.3	-1.4	-1.8	-1.7
Age at first live birth	0.6	1.1	2.5	-1.6	-1.0	0.3	-1.5	-0.4	-0.7
Shortness of breath walking on level ground	0.6	0.7	1.2	-1.0	-0.9	0.4	-1.1	0.3	-1.1
Number of full sisters	0.6	0.8	4.0	0.2	-0.1	2.0	-0.2	0.0	-0.6
Overall health rating	0.6	1.2	1.9	0.8	0.9	-1.0	1.0	1.3	1.4
Leg fat-free mass (right)	0.6	3.4	5.9	-1.9	-2.4	0.9	-1.9	-1.8	-1.7
Mood swings	0.6	1.1	2.9	-1.2	-1.7	0.5	-1.1	0.5	-0.6
Qualifications: nursing, teaching	0.6	0.9	1.5	-1.1	-1.2	-0.0	-1.1	-0.7	-1.0
Illnesses of father: None of the above (group 1)	0.6	0.8	1.2	0.9	1.0	-1.1	1.1	0.2	0.7
Number of self-reported non-cancer illnesses	0.6	1.0	3.8	0.6	0.4	1.9	0.4	-1.2	0.4
Average weekly champagne plus white wine intake	0.6	0.9	2.0	-0.9	-0.4	-0.7	-1.2	-0.7	-1.4
Ever taken oral contraceptive pill	0.6	0.6	1.1	1.0	0.7	0.3	1.0	0.4	1.0
Eye problems/disorders: Glaucoma	0.6	0.8	1.8	-1.0	-0.7	-1.0	-0.5	-1.4	-0.3
Bipolar Disorder or Schizophrenia	0.5	1.2	5.6	-0.1	-0.9	2.4	-0.9	-0.0	-0.3
Breast Cancer	0.5	1.3	3.8	-0.8	-0.3	2.0	-1.1	-0.6	-1.2
Crohns Disease (2012)	0.5	0.8	3.7	-0.0	0.1	-0.4	0.6	-1.9	0.8
Mean Putamen Volume	0.5	0.6	2.0	-1.4	-0.6	0.7	-0.7	0.2	-0.6
Lupus	0.5	0.8	4.3	-0.3	0.1	0.1	0.0	2.1	-0.4
Schizophrenia (2014)	0.5	1.1	4.7	0.0	-0.6	2.2	-0.8	-0.7	-0.4
BMI	0.5	2.7	5.1	1.9	1.0	2.2	1.6	0.1	2.0
Height	0.5	10.1	18.7	-4.0	-3.2	-0.8	-3.7	-1.2	-4.3
Angina	0.5	0.7	1.8	-0.3	-0.5	1.3	-0.3	-1.4	-0.2
Medication: Co-codamol	0.5	0.5	1.9	-0.7	-0.6	-1.4	-0.3	0.5	-0.1
Medication: Metformin	0.5	0.7	1.1	-0.9	-0.8	1.0	-1.0	0.2	-0.9
Impedance of leg (right)	0.5	2.4	4.4	1.7	2.1	-0.6	1.7	1.3	1.5
Taking other prescription medications	0.5	0.7	1.2	1.1	0.9	0.7	0.8	-0.9	0.5
Age when periods started (menarche)	0.5	1.3	3.5	0.5	1.2	-0.9	1.0	-1.9	1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.8	0.6	1.0	1.3	0.4	0.0	0.2
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.6	-0.7	-1.1	-0.7	0.2	-1.0
High blood pressure (mother)	0.5	0.7	2.6	-0.5	-0.8	0.7	-0.3	1.6	-0.5
Hearing difficulty/problems with background noise	0.5	0.8	2.3	-1.1	-1.5	-0.4	-1.1	-0.3	-0.3
Forced vital capacity (FVC)	0.5	1.7	3.0	-1.6	-0.8	-0.1	-1.3	-1.7	-1.6
Medication: Ramipril	0.5	0.7	2.9	-0.5	-0.3	1.7	-0.7	-0.3	-0.6
Hip circumference	0.5	2.0	3.2	1.6	1.0	1.4	1.8	-0.5	1.6
Mouth/teeth dental problems: Dentures	0.5	0.9	2.9	-0.6	-0.4	1.3	-0.3	1.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	5.5	-1.1	-0.8	0.6	-0.8	-2.3	-0.9
Pulse wave reflection index	0.5	0.6	0.9	-0.9	-0.9	0.1	-0.9	-0.6	-0.7
Medication: Paracetamol	0.5	0.8	1.3	-1.2	-1.0	1.0	-1.0	0.4	-0.7
Headache pain in last month	0.5	0.9	2.2	0.8	0.3	0.0	1.2	1.0	1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.5	1.0	0.6	-1.2	0.9	-1.1	0.7
Glaucoma (self-reported)	0.5	0.6	2.6	-0.4	0.0	-1.6	-0.1	-0.7	0.4
Exposure to tobacco smoke outside home	0.5	0.7	3.4	-0.2	0.6	0.5	0.3	1.8	0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.2	0.5	0.4	-1.5	0.7	-0.2	0.5
Leg fat mass (right)	0.5	1.8	2.5	1.5	0.6	1.4	1.6	1.1	1.6
Pulse rate, automated reading	0.5	1.8	3.8	1.3	1.4	-0.3	1.9	0.8	1.6
Had major operations	0.5	0.5	0.8	-0.9	-0.8	-0.3	-0.7	0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.7	-0.2	-0.5	0.6	-0.2	-1.6	0.0
Back pain experienced in last month	0.5	0.7	1.3	-0.3	-1.1	0.7	-1.1	0.4	-1.1
Guilty feelings	0.5	0.7	1.5	-0.9	-1.2	0.0	-1.2	0.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.5	0.8	0.0	-0.1	0.6	1.6	0.6
Risk taking	0.5	0.8	2.1	-0.5	-1.1	0.7	-0.9	-0.2	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.9	0.4	0.0	0.2	0.3	-1.7	0.7
Pack years of smoking	0.5	0.8	2.0	-1.0	-0.6	1.4	-0.8	-0.0	-0.9
Fasting Glucose	0.4	0.5	2.0	-0.3	-0.0	0.2	0.2	-1.4	0.8
Systolic Blood Pressure	0.4	2.2	3.6	1.8	1.8	-0.6	1.9	-0.3	1.7
Allergy or Eczema	0.4	1.1	3.6	-0.6	-0.5	1.3	-0.8	-1.9	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	-0.3	-0.7	1.5	-0.8	-0.5	-0.4
Leg fat-free mass (left)	0.4	2.0	4.2	-1.4	-2.0	0.9	-1.3	-1.5	-1.2
Average weekly fortified wine intake	0.4	0.5	2.1	-0.4	-0.3	-0.5	-0.4	1.4	-0.3
Fed-up feelings	0.4	0.7	3.9	-0.1	-0.4	-0.0	-0.4	2.0	0.1
Leg predicted mass (left)	0.4	2.2	4.5	-1.5	-2.1	0.9	-1.4	-1.5	-1.2
Medication: Simvastatin	0.4	0.6	1.3	-0.4	-0.7	0.7	-0.7	1.1	-0.8
Noisy workplace	0.4	0.5	1.3	0.5	1.1	-0.5	0.7	0.4	0.7
Impedance of arm (left)	0.4	1.9	4.1	-1.1	-1.0	0.9	-1.6	-1.2	-2.0
Tense / ‘highly strung’	0.4	0.6	1.0	-0.8	-0.7	-0.4	-0.9	1.0	-0.5
Body fat percentage	0.4	1.5	5.9	1.0	0.1	2.4	0.8	0.9	0.7
Emphysema/chronic bronchitis	0.4	0.5	2.4	-0.3	-0.3	-1.5	-0.3	0.0	0.4
Medication: Allopurinol	0.4	0.5	1.0	0.6	0.2	0.9	0.7	-0.7	1.0
Medication: Omeprazole	0.4	0.5	2.9	0.0	-0.2	-0.2	0.1	-1.7	0.2
Age at last live birth	0.4	0.5	1.1	-0.5	-0.6	0.9	-1.0	-0.1	-0.8
Leg pain on walking	0.4	0.5	1.9	-0.7	-0.7	-0.5	-0.4	1.4	0.0
Arm fat percentage (left)	0.4	1.4	7.8	0.4	-0.7	2.8	0.0	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	4.0	-0.2	0.3	0.4	-0.2	2.0	-0.1
Asthma (self-reported)	0.4	0.8	3.0	0.1	0.2	-1.2	-0.0	1.7	-0.4
Osteoarthritis (self-reported)	0.4	0.5	0.7	0.7	0.6	-0.7	0.9	0.5	0.7
Financial situation satisfaction	0.4	0.4	1.2	-0.2	1.1	-1.0	0.5	-0.1	0.4
High cholesterol (Self-reported)	0.4	0.8	3.5	0.9	0.4	1.9	0.4	0.3	-0.1
Medication: Paracetamol	0.4	0.7	1.9	-1.4	-0.9	0.7	-0.8	0.0	-0.3
Medication: Atorvastatin	0.4	0.5	2.4	-0.5	-0.4	-0.6	-0.2	1.5	-0.1
Heart disease (siblings)	0.4	0.4	1.5	-0.1	-0.2	1.0	-0.1	-1.2	-0.0
Alcohol drinker status: Previous	0.4	0.5	1.1	1.1	0.6	0.9	0.4	0.6	-0.4
Crohns Disease (2017)	0.3	0.7	3.9	-0.5	-0.1	0.4	-0.1	-2.0	-0.3
Rheumatoid Arthritis	0.3	0.4	1.2	0.2	-0.2	-1.1	0.4	-0.9	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.4	0.1	-0.3	-1.2	-0.2	0.4	0.3
Cardiovascular Disease	0.3	0.9	2.1	0.8	0.5	1.4	1.0	0.7	0.9
Hair Pigment	0.3	8.6	14.5	-3.3	-3.8	0.6	-3.5	1.1	-3.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-0.0	-0.4	-0.7	-0.2	1.3	-0.7
Trunk fat percentage	0.3	1.3	7.0	0.6	-0.1	2.6	0.4	0.3	0.4
Current tobacco smoking	0.3	0.4	1.8	-0.5	-0.3	-0.2	-0.7	-0.1	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.3	-0.1	0.1	0.6	-0.5	-1.8	-0.0
Multivitamins +/- minerals	0.3	0.4	1.7	-0.3	-0.1	1.3	-0.3	0.0	-0.6
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.4	0.4	-1.0	0.5	0.6	0.6
Supplements: Glucosamine	0.3	0.3	1.2	-0.2	-0.4	1.1	-0.5	-0.5	-0.2
Body mass index (BMI)	0.3	1.4	3.7	1.2	0.2	1.9	1.2	0.6	1.3
Trunk fat mass	0.3	1.1	6.1	0.3	-0.5	2.5	0.1	0.0	0.1
Waist circumference	0.3	1.0	2.2	-0.6	-1.5	1.5	-0.6	0.6	-0.5
Financial difficulties in last 2 years	0.3	0.4	1.7	0.3	-0.5	-0.0	0.3	1.3	0.4
Impedance of arm (right)	0.3	1.4	3.9	-1.0	-1.0	0.4	-1.5	-0.1	-2.0
Arm fat percentage (right)	0.3	1.3	6.1	0.6	-0.6	2.5	0.2	0.9	0.2
Trunk fat-free mass	0.3	1.4	3.3	-1.4	-1.8	0.3	-1.2	-0.6	-1.1
Time employed in main current job	0.3	0.3	0.9	0.7	0.3	0.2	0.4	0.4	0.9
Falls in the last year	0.3	0.4	1.1	-0.8	-1.0	-0.3	-0.3	0.6	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	4.0	-0.8	-0.4	-0.3	-0.5	-2.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.3	0.3	-0.4	-1.8	-0.1	0.1	0.2
Asthma	0.3	0.6	2.7	0.1	0.2	-1.0	0.1	1.6	-0.3
Illnesses of mother	0.3	0.4	1.0	-0.2	-0.1	-1.0	-0.4	-0.6	-0.9
Trunk predicted mass	0.3	1.4	3.4	-1.4	-1.8	0.3	-1.2	-0.5	-1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.7	0.6	-0.5	-0.5	0.1	-1.3	0.3
High blood pressure (siblings)	0.3	0.5	1.9	0.5	0.2	1.4	0.7	-0.0	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	-0.1	-0.5	0.8	-0.6	-1.3	0.0
Medication: Blood pressure	0.3	0.5	0.9	-0.9	-0.9	0.9	-0.7	0.4	-0.3
Angina (self-reported)	0.3	0.4	1.1	-0.3	-0.4	0.9	-0.2	-1.1	0.0
Whole body fat-free mass	0.3	1.5	3.3	-1.3	-1.8	0.6	-1.2	-1.0	-1.1
Breast cancer (self-reported)	0.3	0.3	1.0	0.2	-0.2	1.0	-0.0	-0.9	-0.0
Smoking status: Current	0.3	0.4	1.6	-0.5	-0.4	-0.1	-0.7	-0.1	-1.3
Whole body water mass	0.3	1.6	3.6	-1.4	-1.9	0.5	-1.3	-0.9	-1.1
Hearing aid user	0.3	0.4	0.9	-0.9	-0.7	0.5	-0.3	-0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.6	-0.5	-0.0	-0.8	-0.3	-0.7
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-0.4	-0.9	1.1	-0.3	0.5	-0.0
Leg fat mass (left)	0.3	1.2	2.1	1.1	0.2	1.5	1.1	1.1	1.2
Schizophrenia (2018)	0.2	0.5	1.4	0.2	-0.8	1.2	-0.5	-0.7	-0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	-0.1	-0.5	0.1	-0.9	-0.1	-0.8
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.6	0.3	0.0	0.3	0.8	0.7
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-0.7	0.4	-0.4	0.1	-1.1	-0.3
Ovarian Cancer	0.2	0.3	0.6	0.6	0.7	0.7	0.3	-0.1	0.3
Lung FVC	0.2	1.0	2.0	-0.9	-0.7	0.3	-0.9	-1.4	-1.3
Number of treatments/medications taken	0.2	0.3	1.8	-0.1	0.4	1.4	0.1	0.0	0.3
Relative age voice broke	0.2	0.2	0.8	-0.1	0.6	-0.9	-0.1	0.0	-0.5
High blood pressure	0.2	0.5	1.3	0.3	-0.1	1.1	0.8	0.5	1.0
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.5	-0.4	-0.2	-0.7	-0.6	-0.8
Impedance of leg (left)	0.2	0.9	2.0	0.9	1.4	-0.3	0.9	1.1	0.7
Pain all over the body in last month	0.2	0.3	0.6	-0.3	-0.8	0.3	-0.5	0.7	-0.2
Illnesses of siblings	0.2	0.3	0.8	-0.5	-0.4	-0.9	-0.6	-0.1	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.6	-0.1	0.1	-0.7	-0.3	-0.7
Arm fat mass (right)	0.2	0.8	4.1	0.2	-0.9	2.0	0.1	0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.7	0.5	0.2	0.7	0.2	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.8	0.2	-0.4	0.7	0.1	-0.9	0.2
Number of full brothers	0.2	0.3	0.7	0.1	0.2	0.6	0.4	-0.8	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	1.4	0.4	0.6	-0.1	0.3	1.2	0.6
Pulse wave peak to peak time	0.2	0.2	0.4	0.6	0.1	-0.2	0.7	0.3	0.6
Migraine (self-reported)	0.2	0.3	0.9	-0.4	-0.0	0.9	-0.3	-0.5	-0.3
Whole body fat mass	0.2	1.0	4.7	0.5	-0.3	2.2	0.4	0.7	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.4	-0.2	-0.4	0.1	-0.1	1.2	-0.0
Mineral and other dietary supplements	0.2	0.3	0.6	0.6	0.4	-0.1	0.8	0.3	0.7
Arm fat mass (left)	0.2	0.9	5.2	0.3	-0.6	2.3	0.1	0.1	0.2
Mother’s age at death	0.2	0.2	0.5	-0.4	-0.5	0.7	-0.5	-0.1	-0.1
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.9	-0.7	0.2	-0.4	-0.3	0.1
Basal metabolic rate	0.2	1.3	3.1	-1.1	-1.8	0.8	-1.1	-0.8	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.5	-0.1	0.5	-1.6	-0.4	-0.5	-0.6
Cholesterol lowering medication	0.2	0.2	0.5	0.7	0.1	-0.1	0.5	0.7	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.0	-0.4	0.5	-0.1	0.3	-0.1
Ulcerative Colitis (UC)	0.1	0.3	0.8	-0.9	0.4	-0.5	-0.1	-0.5	-0.4
Ulcerative Colitis	0.1	0.2	0.3	-0.2	0.5	-0.1	0.6	-0.2	0.6
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.2	-0.6	0.1	-0.7	-0.3	-0.8
Respiratory disease	0.1	0.3	1.2	0.2	0.3	-0.4	0.3	1.1	0.3
Chronotype (morning person)	0.1	0.1	0.5	-0.4	-0.7	0.0	-0.3	0.1	-0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.6	0.3	0.1	0.4	0.5	0.2	0.8
Relative age of first facial hair	0.1	0.1	0.3	-0.1	0.6	-0.4	0.0	0.2	-0.5
Vitamin and mineral supplements	0.1	0.1	0.5	0.1	-0.7	-0.2	-0.3	0.4	-0.2
Sitting height	0.1	0.8	3.9	-0.1	-0.0	-0.7	0.1	-2.0	-0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	-0.5	-0.1	-0.3	0.1	0.2
Allergy	0.1	0.3	1.7	-0.2	-0.1	-0.2	0.1	1.3	0.1
Weight	0.1	0.7	3.0	-0.2	-1.0	1.7	-0.2	-0.3	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.1	0.2	-0.5	-0.1	-0.8	0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	0.6	0.0	-0.2	0.5	0.7	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.0	-0.5	-0.1	-0.5	-0.3	-0.7
Arm fat-free mass (right)	0.1	0.5	1.2	-0.8	-1.1	0.3	-0.5	-0.7	-0.3
Health satisfaction	0.1	0.2	0.3	-0.6	-0.1	-0.4	-0.5	-0.3	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.7	-0.0	0.2	0.5	-0.4	0.3
Heart disease (mother)	0.1	0.1	0.2	-0.1	0.2	0.5	0.1	0.3	0.3
Arm predicted mass (right)	0.1	0.7	1.4	-0.9	-1.2	0.5	-0.6	-1.0	-0.4
Chest pain or discomfort	0.1	0.2	0.6	0.5	-0.1	0.4	0.4	0.8	0.4
Supplements: Vitamin C	0.1	0.2	0.3	-0.2	0.2	-0.5	0.3	-0.5	0.5
Hypertension (Self-reported)	0.1	0.3	0.8	-0.0	-0.6	0.9	0.5	0.6	0.5
Medication for cholesterol	0.1	0.2	0.8	-0.4	0.2	-0.9	-0.3	-0.0	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.7	-0.3	0.3	0.0	-0.2	0.8	-0.2
Medication: Blood pressure	0.1	0.2	0.6	-0.3	-0.5	0.0	-0.2	0.8	0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.8	-0.1	0.0	-0.3	-0.3	-0.9	-0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.7	-0.5	-0.4	-0.3	0.2	-0.0
Arm fat-free mass (left)	0.1	0.5	1.8	-0.9	-1.3	0.3	-0.6	-0.2	-0.5
Age started oral contraceptive pill	0.1	0.1	0.4	-0.6	0.2	0.4	-0.2	-0.2	0.3
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.1	-0.2	-0.5	-0.5	0.6	-0.4
Arm predicted mass (left)	0.1	0.3	1.2	-0.6	-1.1	0.2	-0.3	0.1	-0.2
Blood Platelet Count	0.0	0.3	0.6	-0.8	0.5	-0.7	-0.4	-0.3	-0.1
Tanning	0.0	0.5	2.1	0.6	0.3	-1.4	0.2	-0.4	-0.2
Diabetes (mother)	0.0	0.0	0.2	0.2	0.0	0.2	-0.0	0.2	-0.4
Unable to work because of sickness or disability	0.0	0.0	0.2	-0.1	-0.4	-0.1	0.1	0.1	0.1
Impedance of whole body	0.0	0.1	0.4	0.0	0.5	0.1	-0.2	-0.2	-0.6

Hub : Genes

U2SURP

Models

Trait associations