Hub : Genes

U3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1470	0.0440	1.0e-05	0.124	NA	0.144	NA	0.148	2.4e-10	NA	8.3e-12	NA	4.0e-12
2	GTEx	Artery Tibial	0.1379	0.0534	4.0e-03	0.000	NA	-0.003	NA	0.005	3.0e-01	NA	7.9e-01	NA	1.2e-01
3	GTEx	Artery Tibial	0.1027	0.0452	1.6e-03	0.046	NA	0.038	NA	0.063	1.7e-04	NA	5.2e-04	NA	1.1e-05
4	GTEx	Brain Frontal Cortex BA9	0.2466	0.1063	7.0e-03	0.027	NA	0.012	NA	0.059	6.6e-02	NA	1.5e-01	NA	1.2e-02
5	GTEx	Breast Mammary Tissue	0.2220	0.0800	3.2e-03	0.112	NA	0.103	NA	0.092	2.2e-06	NA	5.6e-06	NA	1.8e-05
6	GTEx	Breast Mammary Tissue (Male)	0.1381	0.1074	1.3e-01	-0.011	NA	-0.012	NA	-0.011	6.8e-01	NA	8.0e-01	NA	6.7e-01
7	GTEx	Breast Mammary Tissue (Female)	0.0259	0.0575	3.5e-01	-0.009	NA	-0.001	NA	-0.008	7.4e-01	NA	3.6e-01	NA	7.0e-01
8	GTEx	Cells Transformed fibroblasts	0.0970	0.0480	5.9e-03	0.129	NA	0.114	NA	0.123	7.3e-10	NA	6.6e-09	NA	1.8e-09
9	GTEx	Esophagus Mucosa	0.1230	0.0510	1.8e-03	0.074	NA	0.079	NA	0.072	1.1e-05	NA	6.0e-06	NA	1.4e-05
10	GTEx	Nerve Tibial	0.1635	0.0527	2.5e-05	0.156	NA	0.129	NA	0.131	3.7e-11	NA	2.1e-09	NA	1.5e-09
11	GTEx	Stomach	0.2460	0.0860	7.6e-03	-0.005	NA	0.044	NA	0.012	6.4e-01	NA	3.4e-03	NA	8.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.5	0.8	2.8	-0.6	-0.9	0.1	-0.7	-1.2	-1.2	-0.8	-1.7	-0.8	0.7	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.6	-0.2	0.3	-0.0	0.1	-0.2	-0.5	-0.6	-0.6	1.0	-0.2
Depressed Affect (Nagel 2018)	0.3	0.6	3.3	-0.2	-0.7	-1.8	0.2	-0.9	0.4	-0.5	-0.5	-0.3	0.6	-0.7
Depression (Nagel 2018)	0.6	0.9	4.5	-0.1	-0.5	-2.1	-0.1	-1.5	-1.5	-0.2	-0.2	-0.1	-0.4	-0.4
Intelligence (Savage-Jansen 2018)	1.5	4.7	10.3	2.5	3.2	-2.0	2.6	-0.7	0.0	2.8	1.5	2.4	2.4	1.6
Neuroticism (Nagel 2018)	0.4	1.0	3.9	0.2	0.1	-2.0	0.7	-1.5	0.7	0.0	-0.3	0.4	1.8	-0.6
Schizophrenia (2018)	0.2	0.3	1.5	-0.2	0.4	0.2	0.5	1.2	0.7	-0.0	0.6	-0.2	0.9	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	4.2	-0.0	0.5	-1.2	0.5	-0.4	2.1	0.0	-0.3	0.2	0.5	-0.8
Worry (Nagel 2018)	0.5	1.1	3.4	-0.5	-0.5	-1.8	-0.2	-1.6	-0.1	-0.6	-1.2	-0.3	1.5	-1.2
Alzheimer’s Disease (in mother)	0.2	0.3	1.1	0.7	0.4	0.9	-0.1	0.1	-0.1	0.4	-0.1	0.3	-1.0	0.4
Alzheimer’s Disease (in father)	0.6	0.6	1.2	0.9	0.8	0.8	1.1	0.9	0.8	0.9	0.7	0.5	-0.9	-0.1
Alzheimer’s Disease (including proxy)	0.8	1.1	3.6	1.2	1.0	1.0	0.9	0.5	1.0	1.2	0.6	1.1	-1.9	0.7
Crohns Disease (2017)	1.7	3.6	7.4	-1.9	-2.1	1.0	-2.4	-0.8	-2.7	-1.9	-1.7	-1.9	2.6	0.3
Irritable Bowel Disease (IBD)	2.2	5.2	9.6	-2.7	-2.4	0.0	-3.1	-1.8	-3.0	-2.4	-2.5	-2.5	1.9	-0.8
Ulcerative Colitis (UC)	1.5	2.9	4.9	-2.2	-1.8	-1.0	-2.1	-1.4	-1.8	-1.8	-2.0	-2.1	0.4	-0.9
Major Depression (MDD)	1.9	2.3	4.2	-1.5	-2.0	-0.7	-1.9	-0.2	-1.9	-1.7	-1.5	-1.9	1.1	0.7
Reaction Time	1.7	3.2	11.4	-1.6	-1.6	1.5	-2.2	-1.3	-1.8	-1.6	-1.0	-1.5	1.0	-3.4
Verbal and Numeric Reasoning (VNR)	2.1	4.9	10.1	2.6	3.2	-1.5	2.8	-0.5	1.2	2.8	2.2	2.5	2.1	1.6
Breast Cancer	0.0	0.1	0.3	-0.1	-0.2	-0.4	0.0	0.4	-0.0	0.2	0.1	0.3	0.5	0.6
Ovarian Cancer	1.2	1.5	3.5	-1.4	-1.2	1.4	-1.6	-0.6	-1.9	-1.4	-0.5	-1.4	0.8	-0.6
Prostate Cancer	0.5	0.8	4.1	-0.1	-0.5	1.2	-0.7	-0.3	-1.1	-0.3	-0.5	-0.4	-2.0	0.6
Age at First Birth	0.5	0.7	1.6	0.5	1.3	-1.0	1.1	-0.1	1.3	0.8	-0.1	0.8	-1.0	-0.1
Bipolar Disorder (2011)	0.8	0.8	3.4	-0.2	-0.6	0.7	-0.4	0.6	-1.5	-0.2	-1.0	-0.3	1.8	-0.5
Body Mass Index (BMI) (2010)	0.4	0.5	2.7	0.5	0.1	1.3	0.1	0.3	0.1	0.1	0.4	0.1	-0.9	1.6
Coronary Artery Disease (CAD)	0.2	0.3	1.6	0.1	0.4	-0.6	0.5	-0.6	0.4	0.4	-0.1	0.5	1.3	-0.1
Crohns Disease (2012)	1.4	2.2	9.7	-1.1	-1.3	0.1	-1.4	-0.5	-1.9	-1.4	-1.2	-1.3	3.1	0.9
Mean Putamen Volume	0.3	0.3	0.8	0.8	0.7	0.9	0.4	0.8	0.4	0.4	0.4	0.3	0.4	-0.4
Fasting Glucose	0.7	0.8	3.3	-0.9	-0.5	-0.7	-1.0	-1.8	-0.4	-0.7	-0.9	-0.2	-1.3	-0.1
HbA1C	0.5	0.5	3.9	0.1	0.2	0.3	0.9	-0.0	2.0	-0.1	-0.2	0.0	-0.3	1.0
HDL Cholesterol	0.1	0.2	0.5	-0.1	0.1	-0.3	0.3	-0.4	0.6	0.4	-0.5	0.4	0.3	-0.7
LDL Cholesterol	0.1	0.2	0.5	-0.4	-0.6	0.4	-0.7	0.5	-0.2	-0.4	-0.0	-0.3	0.4	-0.7
Lupus	0.2	0.3	1.3	-0.1	-0.5	0.6	-0.6	-0.4	-1.1	-0.2	0.4	-0.2	-0.5	0.5
Neuroticism (2016)	0.6	0.9	3.1	-0.4	-0.5	-0.4	-0.9	-1.3	0.1	-0.7	-1.3	-0.8	1.8	-0.7
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.6	-0.7	0.6	-0.4	0.3	0.3	-0.3	-0.0	-0.0	0.5	-0.1
Rheumatoid Arthritis	0.6	0.9	3.0	0.8	0.8	-0.6	1.0	-1.7	1.6	0.2	0.1	0.5	1.1	0.3
Schizophrenia (2014)	0.1	0.2	0.9	-0.6	-0.1	0.0	0.1	0.6	0.9	-0.5	-0.2	-0.6	0.3	-0.0
Triglycerides	0.3	0.4	2.4	-0.1	-0.5	0.3	-0.3	0.8	0.3	-0.5	0.3	-0.3	0.9	1.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	0.0	0.3	0.5	-0.1	-0.1	0.2	0.0	0.4	0.2	0.7	-0.2
Ulcerative Colitis	1.3	1.9	3.8	-1.8	-1.5	-1.1	-2.0	-1.4	-0.8	-1.5	-1.1	-1.7	1.1	-0.5
Blood Eosinophil Count	0.4	2.9	6.5	-2.1	-2.5	-1.0	-1.2	-1.1	-1.1	-2.2	-2.1	-2.4	-0.8	-0.7
Blood Platelet Count	0.1	1.0	7.1	0.0	0.1	0.6	-0.9	-0.0	-2.7	0.8	-0.4	0.6	0.2	1.1
Blood Red Count	0.2	1.5	7.9	-1.3	-0.8	2.8	-1.5	0.6	-0.2	-1.1	0.8	-1.0	0.7	0.9
Blood White Count	0.5	3.4	6.3	2.0	2.4	-0.2	2.5	2.1	1.1	2.5	1.7	2.4	1.1	-0.2
Heel T-Score	0.3	2.2	8.8	0.7	0.8	-0.4	1.4	-0.1	1.6	1.3	1.3	1.6	-3.0	1.8
BMI	0.5	3.1	8.2	-2.1	-2.9	2.2	-1.7	0.4	-0.7	-2.4	-0.6	-2.2	-1.4	-0.3
Height	0.7	13.7	30.9	3.8	4.8	-0.8	5.6	1.5	2.1	5.0	2.3	4.6	-4.2	2.2
Waist Hip Ratio (WHR)	0.2	0.8	4.0	0.0	0.4	-1.2	0.4	-2.0	0.2	0.1	-0.8	0.3	-1.1	0.9
Systolic Blood Pressure	0.5	2.6	5.7	1.8	1.5	1.0	1.6	-0.8	0.8	2.2	0.9	2.4	-2.1	-1.5
Smoking Status	0.1	0.2	0.5	-0.6	-0.6	0.6	0.2	-0.4	-0.2	-0.3	-0.2	-0.3	0.2	0.7
Allergy or Eczema	0.6	1.6	4.0	-1.1	-1.1	0.0	-1.6	-2.0	-0.4	-0.8	-1.8	-0.6	-2.0	-0.8
Cardiovascular Disease	0.3	1.0	2.7	-1.2	-1.6	-0.3	-0.8	-1.3	0.8	-1.0	-1.2	-0.5	-0.1	-0.9
Hypothyroidism (self reported)	0.5	1.1	5.7	0.1	0.6	-2.4	1.1	1.6	0.5	0.4	0.8	0.4	-0.8	0.5
Respiratory disease	0.4	0.9	2.2	-1.4	-1.3	0.2	-0.9	-1.5	0.4	-0.8	-1.2	-0.7	0.6	0.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.0	-1.4	-1.5	-0.2	-1.4	-2.0	-0.5	-1.6	-2.0	-1.5	0.1	0.2
Lung FEV1/FVC ratio	0.1	0.5	1.8	0.1	0.4	1.2	0.0	-0.1	1.0	-0.5	0.9	-0.3	-1.3	-0.2
Lung FVC	0.5	2.3	7.6	1.4	1.5	0.5	1.3	2.0	1.3	1.1	2.8	1.3	1.5	0.8
Neuroticism	0.5	1.3	3.9	-0.9	-1.1	-2.0	-0.5	-1.7	-0.5	-1.0	-1.0	-0.8	1.4	-0.3
Chronotype (morning person)	1.0	2.3	5.5	2.3	2.4	-0.1	1.9	-0.2	0.7	2.1	1.4	1.8	0.5	0.4
Hair Pigment	0.0	0.4	2.4	0.0	-0.2	-1.0	-0.4	0.2	0.1	-0.5	-0.8	-0.6	-0.1	1.5
Tanning	0.0	0.1	0.4	-0.2	0.1	0.4	-0.6	-0.1	0.7	0.1	0.1	0.2	-0.6	0.3
Hand grip strength (left)	0.1	0.3	0.9	-0.5	-0.0	0.8	0.2	0.0	0.8	0.0	0.8	-0.0	-0.6	0.9
Number of treatments/medications taken	2.6	4.7	12.6	-2.9	-2.7	-0.9	-2.0	-2.4	-0.3	-2.5	-3.6	-2.5	0.6	0.5
Average weekly spirits intake	0.4	0.5	2.3	-0.3	-0.5	1.0	0.0	-0.2	-1.0	0.1	-1.5	-0.0	1.0	0.5
Sensitivity / hurt feelings	0.6	1.0	4.9	0.9	1.1	-0.7	0.9	-1.3	0.3	0.8	-0.1	0.9	2.2	0.1
Frequency of depressed mood in last 2 weeks	0.7	0.9	3.3	0.0	-0.3	-1.4	-0.2	-1.8	-1.7	0.0	-0.3	0.1	-0.2	-1.3
Hearing difficulty/problems: Yes	1.9	2.9	6.8	-1.5	-1.8	-0.2	-1.4	-1.6	-2.0	-1.7	-2.6	-1.9	-1.9	0.7
Relative age of first facial hair	1.8	3.8	8.4	2.5	2.8	0.1	2.8	-0.0	1.1	2.7	1.7	2.9	0.3	0.3
Other serious medical condition/disability diagnosed by doctor	3.3	4.3	8.6	-2.6	-2.8	-1.1	-2.0	-1.8	-1.2	-2.5	-2.9	-2.6	0.1	-1.4
Ever used hormone-replacement therapy (HRT)	1.4	1.7	2.9	-1.7	-1.3	-1.4	-1.3	-1.4	-0.7	-1.4	-1.6	-1.3	1.3	0.8
Ever had hysterectomy (womb removed)	0.5	0.6	3.1	0.0	0.0	-0.6	-0.8	0.1	-1.8	0.2	-0.2	0.1	1.2	0.9
Systolic blood pressure, automated reading	0.2	0.5	4.7	0.2	0.0	0.3	0.4	-0.3	0.4	0.6	-0.2	0.5	-2.2	-0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.9	-0.7	-0.7	-2.2	-0.6	-2.2	-1.0	-0.6	-1.8	-0.7	0.9	-0.7
Angina	2.1	2.8	8.9	-1.6	-1.4	-2.5	-0.8	-2.5	-0.6	-1.4	-3.0	-1.4	-0.3	-0.0
Medication for hormone replacement therapy	0.8	0.9	3.3	1.0	1.1	-0.6	1.1	0.8	0.3	1.0	0.4	1.1	1.8	0.0
Vitamin and mineral supplements	0.8	1.0	5.5	0.5	0.7	-1.7	0.7	-0.1	0.6	0.4	0.4	0.5	-0.8	2.3
Supplements: Zinc	0.9	1.0	2.3	-0.7	-0.6	-0.8	-1.1	0.7	-1.1	-0.9	-1.3	-1.1	0.7	-1.5
Medication: Co-codamol	1.8	2.1	4.4	-1.8	-1.8	0.7	-1.3	-1.0	0.4	-2.1	-1.6	-2.1	-1.0	-1.0
Medication: Metformin	0.4	0.5	1.8	0.2	0.4	-1.4	0.5	-0.9	0.6	0.8	0.2	0.8	0.6	-0.8
Diabetes (father)	1.2	1.5	4.6	-0.7	-1.0	0.6	-1.1	-1.3	-2.1	-0.9	-1.1	-1.0	-2.1	-0.8
Diabetes (mother)	0.5	0.7	2.1	0.8	0.8	0.1	0.7	0.2	0.9	0.9	0.4	1.1	-1.4	0.8
Severe depression (siblings)	0.4	0.5	1.0	0.9	0.5	-0.7	1.0	0.1	0.9	0.7	0.4	0.9	-0.3	-0.4
Pack years adult smoking proportion	1.2	1.9	8.6	1.7	1.0	0.2	1.2	0.8	0.5	1.7	0.5	1.5	-0.6	2.9
Impedance of leg (right)	1.0	4.8	10.7	-2.3	-1.9	-2.2	-2.4	-1.6	-2.4	-2.3	-3.3	-2.8	1.3	-0.3
Leg fat-free mass (left)	0.5	2.4	6.8	1.3	1.0	1.9	1.8	1.8	0.2	1.7	2.6	1.8	-1.1	0.2
Trunk fat percentage	0.2	0.7	4.2	-0.5	-0.4	0.3	-0.3	1.7	-0.5	-0.2	0.2	-0.3	-2.0	-0.2
Hand grip strength (right)	0.9	2.3	4.8	0.7	1.3	2.0	1.5	0.7	1.9	1.6	2.2	1.7	-0.2	1.6
Townsend deprivation index at recruitment	0.2	0.2	1.2	0.0	-0.1	-0.2	0.0	0.0	-1.0	0.2	-0.4	0.0	0.3	-1.1
Current tobacco smoking	0.3	0.5	3.1	-0.2	-0.7	0.5	-0.1	0.9	-1.8	0.2	-0.1	-0.1	-0.2	0.7
Average weekly fortified wine intake	0.5	0.6	3.0	0.8	0.5	-1.7	1.0	0.1	0.1	0.6	-0.2	0.4	1.1	-0.5
Maternal smoking around birth	0.4	0.6	2.0	-0.9	-1.1	0.7	-0.5	-1.4	-0.0	-0.4	0.5	-0.3	-0.2	1.0
Fed-up feelings	1.4	2.5	4.5	-1.6	-2.1	-0.2	-1.9	-1.9	-1.6	-2.0	-1.8	-1.9	-0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.6	-0.9	-1.3	-1.6	-1.3	-1.2	-2.1	-1.0	-1.0	-1.0	-0.7	-0.5
Relative age voice broke	3.1	4.8	10.8	2.7	3.3	-0.8	2.8	-0.6	1.1	3.1	1.7	3.2	-0.1	1.1
Taking other prescription medications	2.2	3.4	7.8	-2.1	-2.3	-1.2	-1.6	-1.4	-0.6	-2.2	-2.8	-2.2	-1.0	1.5
Age when periods started (menarche)	0.7	1.7	4.1	1.6	2.0	-0.2	1.3	-0.6	0.0	2.0	0.6	1.7	0.8	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.8	-0.3	0.0	-0.4	-0.6	0.1	-0.9	-0.0	-0.2	-0.1	1.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.6	-1.0	-0.9	-0.8	-0.4	-1.0	1.1	-0.7	-0.2	-0.4	-1.3	1.6
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.8	1.0	1.0	-1.0	0.6	-0.9	1.7	0.9	0.3	1.0	1.0	0.0
Qualifications: CSEs or equivalent	0.9	1.2	4.0	-0.8	-1.6	0.6	-2.0	-0.0	-1.6	-1.0	0.3	-1.0	-0.8	-0.8
Serious illness, injury or assault to yourself	0.6	0.7	1.7	-0.7	-1.0	-1.3	-0.6	-0.5	0.4	-1.1	-0.2	-0.9	0.2	-1.1
High blood pressure	0.9	2.4	6.7	-1.8	-1.9	-0.5	-1.2	-2.6	0.3	-1.5	-2.3	-1.2	1.6	0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.3	-0.6	-0.6	0.4	-0.7	-1.4	-0.2	-0.3	-1.6	-0.1	-1.8	-0.9
Multivitamins +/- minerals	0.6	0.8	4.6	-0.4	-0.7	1.6	-0.5	-0.3	0.4	-0.2	-0.5	0.0	0.2	-2.1
Stomach or abdominal pain in last month	0.4	0.5	2.4	-0.5	-0.5	0.5	-0.9	-0.4	-0.9	-0.6	-0.1	-0.4	1.6	-0.1
Supplements: Glucosamine	1.4	1.9	3.9	-1.7	-2.0	-0.4	-1.6	-0.3	0.4	-1.8	-0.9	-1.4	1.1	-1.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.1	0.8	0.6	0.3	0.6	-1.4	0.8	0.5	0.8	0.4	-1.1	0.0
Medication: Atenolol	0.7	0.8	2.5	-0.4	-0.5	-1.1	0.7	1.1	1.4	-0.4	-1.1	-0.4	1.6	0.2
Medication: Levothyroxine sodium	0.2	0.4	1.5	-0.4	-0.0	-1.2	0.1	0.5	0.5	-0.3	0.2	-0.2	-0.9	0.9
Sitting height	0.5	3.5	6.4	2.1	2.2	-0.2	2.3	2.5	-0.5	2.5	2.2	2.2	-1.3	0.6
Chronic bronchitis/emphysema (father)	1.9	2.2	5.8	-1.3	-1.6	1.2	-1.8	0.1	-1.8	-1.5	-1.2	-1.4	-0.7	2.4
High blood pressure (mother)	0.4	0.6	2.6	0.7	0.4	0.3	0.9	0.6	1.6	0.4	0.6	0.5	0.2	-1.2
Body mass index (BMI)	0.3	1.5	4.1	-1.3	-2.0	2.0	-1.1	0.8	-0.8	-1.3	0.2	-1.1	-1.1	0.2
Impedance of leg (left)	0.9	4.4	9.3	-2.2	-1.7	-2.2	-2.5	-1.4	-2.5	-2.2	-3.1	-2.6	0.7	-0.3
Leg predicted mass (left)	0.5	2.4	6.5	1.4	1.1	1.8	1.8	1.8	0.2	1.8	2.5	1.8	-1.0	0.2
Trunk fat mass	0.2	0.7	3.7	-0.1	-0.2	0.8	0.3	1.7	-0.4	0.2	0.8	0.1	-1.9	0.3
Waist circumference	0.1	0.5	2.7	-0.6	-1.0	0.9	-0.1	0.5	-0.4	-0.5	0.4	-0.4	-1.6	0.4
Number of incorrect matches in round	1.1	1.8	7.0	-0.9	-0.9	2.1	-0.5	2.1	0.1	-0.8	0.0	-0.8	0.9	-2.7
Past tobacco smoking	0.7	1.3	6.4	1.5	0.7	0.2	0.4	2.5	-0.1	1.1	1.4	1.0	-0.3	-0.2
Alcohol usually taken with meals	0.4	0.6	2.5	0.5	0.9	0.2	1.0	0.8	1.6	0.3	0.9	0.3	-0.1	-0.4
Nervous feelings	0.3	0.5	2.5	0.7	0.7	0.2	0.4	-0.5	0.2	0.5	-0.6	0.4	1.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	3.9	1.4	0.9	0.3	0.7	0.4	-1.9	1.1	0.8	1.0	-0.0	-2.0
Hearing difficulty/problems with background noise	1.4	2.2	4.7	-1.8	-1.9	-0.3	-1.8	0.2	-1.2	-2.0	-1.6	-2.2	1.3	0.4
Hair/balding pattern: Pattern 2	1.6	2.1	6.1	-1.2	-1.5	0.7	-2.0	-0.6	-2.5	-1.1	-0.7	-1.4	-1.6	-1.6
Had menopause	2.4	3.0	6.1	-2.5	-1.9	-0.3	-2.2	-1.1	-1.3	-2.2	-2.1	-2.1	-0.2	-1.3
Had other major operations	1.1	1.4	3.0	1.2	1.3	0.6	0.8	1.2	-1.7	1.6	0.6	1.3	1.3	0.8
Forced vital capacity (FVC)	1.1	4.2	8.5	2.4	2.5	1.5	2.4	1.8	0.8	2.6	2.9	2.4	-0.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	4.0	-0.4	-0.2	-1.0	0.6	-0.4	2.0	-0.1	0.4	0.1	-1.0	1.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.5	-0.5	-1.0	-0.2	-1.3	-0.7	-1.4	-0.9	-0.9	-1.1	1.6	-1.1
Qualifications: None of the above	1.3	2.7	6.4	-1.9	-2.5	0.4	-1.7	-1.4	-1.4	-1.9	-2.2	-2.2	0.6	-0.1
Financial difficulties in last 2 years	0.4	0.6	3.9	0.2	-0.0	-0.5	-0.2	-2.0	-1.3	0.4	-0.3	0.2	-0.2	0.4
Mouth/teeth dental problems	0.8	1.3	6.6	0.3	0.6	0.3	0.9	2.0	0.7	0.6	0.9	0.6	2.6	0.1
Heart attack	0.2	0.2	0.7	-0.2	-0.4	0.4	-0.2	-0.1	-0.8	-0.1	-0.7	-0.3	0.4	0.6
Allergy	1.1	2.6	7.1	1.7	1.7	-0.5	2.1	1.4	1.5	1.3	2.7	1.2	1.8	-0.4
Pain all over the body in last month	0.5	0.5	1.6	0.2	-0.7	-0.5	-0.5	-1.3	0.2	-0.5	-1.0	-0.8	-0.1	-0.9
Diabetes (self-reported)	0.6	0.9	3.4	0.4	0.5	-1.9	0.6	-1.5	1.2	0.3	0.1	0.4	1.3	0.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.0	-1.1	-1.2	0.7	-1.3	-1.3	-0.6	-1.0	-1.7	-1.1	-0.9	0.2
Medication: Ramipril	0.6	0.8	3.7	0.7	0.6	-0.2	1.2	-0.4	1.9	0.5	0.8	0.7	-0.2	0.8
Medication: Simvastatin	0.3	0.4	1.7	-0.2	-0.3	-0.7	0.4	0.3	1.3	-0.2	-1.1	-0.2	-0.9	0.1
Fluid intelligence score	0.9	1.8	4.5	1.6	2.0	-0.3	1.6	0.0	-0.0	1.5	1.2	1.1	2.1	1.3
Illnesses of siblings	2.0	2.8	5.7	1.7	1.8	1.7	2.1	1.5	1.4	1.8	2.4	1.8	-0.4	0.9
Neuroticism score	0.3	0.7	2.1	-0.3	-0.7	-0.8	0.0	-1.4	-0.4	-0.5	-1.0	-0.4	1.5	-0.7
Weight	0.2	0.9	2.2	0.0	-0.4	1.5	0.5	1.4	-0.8	0.4	1.3	0.3	-1.5	0.4
Impedance of arm (right)	0.4	2.1	5.7	1.4	2.3	-2.4	1.1	1.7	1.5	1.3	0.4	1.1	-0.6	-0.5
Arm fat percentage (right)	0.2	0.7	3.2	-0.2	-0.4	1.3	-0.1	1.8	0.0	-0.2	0.9	-0.2	-1.5	-0.3
Trunk fat-free mass	0.3	1.5	3.3	1.0	0.3	1.6	1.8	0.9	-0.8	1.3	1.8	1.3	-1.0	1.0
Hip circumference	0.2	1.0	2.8	-0.7	-1.2	1.7	-0.4	1.4	-1.0	-0.4	0.4	-0.5	-1.6	-0.4
Time employed in main current job	2.0	2.3	6.2	2.0	2.5	1.0	1.7	0.3	0.2	2.2	1.1	2.1	-0.3	0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.4	0.2	-0.1	0.1	0.4	-0.6	0.4	0.3	0.4	0.5	0.1
Father’s age at death	1.4	1.9	7.1	0.9	1.3	-2.7	1.7	0.3	1.6	1.1	1.1	1.1	-1.0	-0.9
Worrier / anxious feelings	0.6	1.0	5.6	0.3	0.6	-2.4	0.5	-1.5	-0.3	0.4	-1.1	0.3	0.9	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	-0.7	-1.0	-0.5	-1.1	0.2	-0.5	-1.0	-0.4	-0.7	0.1	-1.0
Falls in the last year	0.6	0.8	4.7	0.1	-0.3	0.4	-0.8	-1.1	-2.2	-0.2	-0.9	-0.5	-0.1	0.7
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	1.0	1.5	-1.2	1.2	1.2	-0.2	1.1	0.2	1.1	-0.4	-0.3
Number of live births	1.5	2.2	4.8	-1.7	-1.8	1.4	-1.1	-0.3	0.8	-1.7	-1.8	-1.7	0.2	2.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	8.1	2.0	2.1	2.1	1.9	1.8	0.8	1.9	2.9	1.7	-0.6	0.6
Pulse rate	4.8	8.2	17.6	3.5	4.2	1.2	3.5	2.3	0.8	3.7	3.6	3.6	-1.0	0.2
Happiness	0.6	0.7	2.3	0.1	-0.2	1.2	-0.3	1.3	-1.5	0.1	0.3	0.2	-0.3	1.5
Noisy workplace	1.7	2.1	6.4	-0.3	-0.6	-1.5	-1.2	-2.4	-2.5	-0.7	-2.1	-0.9	-0.4	1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.3	1.3	1.8	-0.8	1.1	1.2	-0.1	1.6	1.4	1.7	-0.1	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.2	-0.3	-0.3	-0.2	0.4	0.1	-0.4	-0.5	-0.6	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.7	1.2	2.4	-1.0	-1.5	0.7	-0.8	-0.3	0.1	-1.1	-1.4	-1.0	-1.2	1.6
Asthma	0.7	1.4	3.9	-1.4	-1.4	0.4	-1.5	-0.9	-1.5	-1.0	-2.0	-1.0	-0.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	6.4	-2.0	-2.2	-0.4	-2.0	-2.5	-0.8	-2.3	-1.4	-2.1	1.5	0.2
Medication: Cholesterol lowering	0.2	0.3	1.1	0.4	0.4	-0.7	0.8	1.0	1.0	0.5	-0.4	0.2	0.1	-0.1
Depression (self-reported)	0.6	0.7	1.7	-1.1	-1.3	-0.1	-0.9	-0.4	-1.2	-0.8	-0.7	-0.8	0.3	0.1
Medication: Lansoprazole	1.5	1.8	4.4	-1.6	-1.7	-2.1	-1.3	0.2	-0.5	-1.5	-1.4	-1.7	-0.2	-0.7
Prospective memory result	3.2	3.9	7.2	-2.5	-2.6	1.7	-2.4	-1.0	-1.8	-2.4	-1.5	-2.7	0.9	-0.6
Lung cancer (father)	0.3	0.4	1.9	0.1	0.3	-0.7	0.6	0.4	1.4	0.3	-0.4	0.3	-0.6	-0.7
Illnesses of mother	0.4	0.5	2.8	-0.1	-0.2	0.9	0.3	0.6	-1.7	-0.0	0.3	-0.2	0.7	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	7.3	2.1	2.0	1.5	2.2	1.4	0.8	1.9	2.7	1.6	-1.7	0.7
Pulse wave Arterial Stiffness index	0.5	0.6	2.3	-0.1	0.0	-1.0	-0.3	-0.6	-1.2	-0.0	-1.3	-0.3	-0.4	-1.5
Impedance of arm (left)	0.6	2.7	7.9	1.6	2.8	-2.1	1.5	1.7	1.9	1.7	0.6	1.5	-0.5	-0.4
Arm fat mass (right)	0.2	0.8	2.2	-0.2	-0.5	1.5	0.1	1.5	-0.4	0.0	1.2	-0.0	-1.5	0.3
Trunk predicted mass	0.3	1.7	4.0	1.1	0.5	1.4	2.0	0.9	-0.7	1.5	1.9	1.4	-1.0	1.0
Standing height	0.6	5.7	12.5	2.6	3.2	-0.6	3.5	1.6	-0.0	3.5	2.5	3.0	-1.5	0.3
Length of working week for main job	3.0	3.3	7.6	2.8	2.4	1.4	2.1	0.7	-0.5	2.2	2.1	1.9	-1.8	-0.2
Exposure to tobacco smoke at home	1.9	2.1	5.4	-1.5	-2.0	-0.2	-1.7	-0.1	-2.3	-1.6	-1.3	-1.7	0.8	0.5
Breastfed as a baby	3.0	3.8	10.3	2.1	2.3	-0.8	2.5	3.2	1.4	2.2	1.7	2.2	-0.5	0.6
Tense / ‘highly strung’	0.9	1.5	3.5	-1.4	-1.9	-0.4	-1.3	-0.5	-1.4	-1.2	-1.3	-1.2	1.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.4	6.5	-2.0	-2.5	-0.5	-2.2	-0.7	-2.2	-2.1	-2.5	-2.0	0.6	-1.4
Hair/balding pattern: Pattern 4	0.8	1.9	9.5	0.0	0.1	-1.9	0.6	-2.2	3.1	-0.4	-0.1	-0.3	1.3	0.5
Birth weight of first child	0.8	1.4	5.2	-1.3	-1.0	-0.3	-0.9	-0.0	-2.3	-0.8	-1.6	-1.6	0.6	-0.3
Peak expiratory flow (PEF)	0.3	0.6	2.2	-0.4	-0.1	1.5	-0.6	1.0	-0.9	-0.4	1.2	-0.7	0.6	-0.1
Pulse wave reflection index	1.9	2.3	3.5	-1.3	-1.8	-1.7	-1.3	-0.9	0.3	-1.8	-1.4	-1.9	1.7	-1.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	-0.1	-0.4	-0.8	-0.2	-1.4	-0.3	0.0	-0.6	0.1	0.7	1.4
Loud music exposure frequency	1.0	1.0	3.4	0.6	0.3	1.7	0.8	0.4	0.2	0.5	0.5	0.6	-1.8	1.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	2.2	0.2	0.5	-0.1	0.0	-0.2	-0.1	0.3	-0.2	0.3	-0.8	1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	4.5	0.6	0.9	-0.4	-0.1	-2.0	-0.5	0.2	0.1	0.0	-2.1	-1.3
Blood clot in the leg (DVT)	3.6	4.7	9.5	-2.7	-2.8	1.1	-3.1	-1.7	-1.6	-2.6	-2.1	-2.7	-0.3	0.8
Medication: Paracetamol	3.5	5.9	9.7	-2.9	-2.8	-1.8	-3.1	-1.7	-2.2	-2.9	-3.1	-3.0	0.5	-0.4
Headache pain in last month	0.5	0.9	4.5	0.6	0.5	0.7	0.4	1.8	-0.1	0.8	0.2	0.8	2.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.9	-0.0	0.1	0.8	-0.6	-0.4	-1.4	-0.1	0.3	-0.1	0.7	0.7
Glaucoma (self-reported)	0.3	0.3	1.0	-0.1	-0.6	1.0	-0.2	0.4	0.4	-0.3	-0.7	-0.3	0.6	1.0
Gout (self-reported)	0.6	0.8	2.0	0.8	0.9	0.2	0.8	0.7	1.0	0.8	1.2	0.7	-0.3	1.4
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	5.9	-0.2	0.3	-2.4	0.6	1.3	0.6	0.1	0.2	0.0	-0.4	1.3
Medication: Amlodipine	2.1	3.0	4.9	-1.8	-2.2	-0.8	-1.8	-2.2	0.3	-2.1	-1.7	-2.1	-1.8	-1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.7	-0.7	0.3	-0.6	-0.6	-0.7	-0.4	-1.3	-0.7	-0.2	-0.6
Birth weight	0.6	1.3	6.3	0.8	1.0	-0.5	1.3	-0.9	0.6	1.1	0.9	0.9	0.8	2.5
Chronic bronchitis/emphysema (mother)	1.9	2.2	5.3	-1.5	-1.8	-1.4	-1.3	-2.3	0.2	-1.7	-1.6	-1.4	0.8	1.1
High blood pressure (siblings)	0.3	0.5	1.4	-0.3	-0.2	-0.8	-0.8	-0.9	-1.0	-0.3	-1.2	-0.4	-0.3	-0.3
Forced vital capacity (FVC), Best measure	1.1	4.2	8.4	2.5	2.4	1.0	2.7	1.6	1.1	2.5	2.9	2.3	-0.9	1.3
Body fat percentage	0.2	0.9	2.3	-1.1	-1.1	0.7	-0.8	1.5	-0.8	-0.8	-0.0	-1.0	-1.5	-0.2
Leg fat percentage (right)	1.3	4.8	11.4	-2.8	-3.4	1.6	-2.7	0.3	-2.0	-2.9	-1.5	-3.1	-0.1	-0.2
Arm fat-free mass (right)	0.2	1.0	2.7	0.5	0.1	1.4	1.3	0.6	-1.1	1.1	1.7	1.0	-0.5	0.6
Exposure to tobacco smoke outside home	1.9	2.5	5.0	-1.2	-2.2	2.1	-1.7	-0.7	-0.4	-1.7	-1.0	-1.7	1.6	2.0
Comparative body size at age 10	0.4	1.0	3.8	-0.2	-0.8	1.9	-0.6	1.2	0.1	-0.8	0.5	-0.5	1.8	0.4
Number of full brothers	2.2	2.7	12.0	-1.1	-1.2	0.7	-1.8	-0.5	-2.4	-1.2	-1.3	-1.6	3.5	0.2
Worry too long after embarrassment	0.6	1.0	4.4	0.6	1.0	-2.1	0.8	-1.3	0.4	0.7	0.1	0.9	0.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	4.6	6.0	9.9	-2.8	-2.9	-1.8	-2.9	-2.4	-2.2	-2.7	-3.1	-2.6	1.3	-1.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.8	-0.8	-1.3	0.5	-0.7	-0.8	-1.7	-0.4	-1.4	-0.5	0.5	0.6
Number of children fathered	0.9	1.1	5.9	-0.4	-0.8	1.1	-0.2	-1.3	-0.6	-0.4	-0.9	-0.4	-0.6	2.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	-0.8	-0.9	0.9	0.5	-0.3	0.9	-0.3	-0.9	-0.4	0.8	-0.9
Age at first live birth	1.4	2.5	6.0	1.7	2.4	-0.1	2.0	-0.0	1.8	1.6	1.5	1.5	-2.1	0.0
Pulse wave peak to peak time	0.7	0.8	2.8	0.3	0.3	0.9	0.6	1.0	1.2	0.3	1.7	0.6	0.3	1.4
Health satisfaction	1.0	1.2	3.1	-1.4	-1.8	0.1	-1.3	-0.1	-0.2	-1.4	-1.5	-1.4	0.4	-0.7
Shortness of breath walking on level ground	0.3	0.3	1.2	0.2	-0.1	-0.7	0.6	0.6	-0.4	0.2	-0.2	0.3	-0.9	-1.1
Qualifications: College or University degree	2.3	7.3	16.2	2.6	3.5	-0.4	4.0	3.6	2.5	2.8	3.1	2.7	-0.5	0.9
Eye problems/disorders: None of the above	1.9	2.2	5.8	-2.1	-1.9	0.2	-2.4	-0.8	-1.1	-2.0	-0.8	-2.0	0.0	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.6	0.5	0.6	-0.2	0.5	-0.6	-1.3	0.5	-0.1	0.5	0.8	-0.5
Emphysema/chronic bronchitis	1.0	1.2	3.8	-1.0	-1.0	-2.0	-0.8	-1.2	0.1	-0.7	-1.7	-0.9	-0.6	0.6
Medication for pain relief, constipation, heartburn	4.8	8.1	15.2	3.7	3.9	1.3	3.4	1.8	1.2	3.9	3.6	3.9	-0.5	0.2
Neck or shoulder pain in last month	1.8	2.5	6.7	-2.3	-2.6	-0.6	-2.3	-0.6	0.0	-2.2	-1.1	-1.7	0.9	-0.1
Medication: Blood pressure	0.4	0.8	4.0	-0.5	-0.7	-2.0	-0.1	-1.2	0.7	-0.4	-0.9	-0.3	-0.1	-0.9
Angina (self-reported)	2.0	2.6	8.0	-1.5	-1.3	-2.6	-0.7	-2.4	-0.4	-1.2	-2.8	-1.2	-0.4	0.0
Migraine (self-reported)	0.2	0.3	1.2	-0.4	-0.7	0.1	-0.5	-0.9	-0.4	-0.1	0.2	0.1	0.1	1.1
Medication: Ibuprofen	2.2	2.7	5.6	-1.6	-1.9	-0.2	-1.8	-2.4	-1.2	-2.2	-1.5	-2.2	1.2	-0.1
Medication: Allopurinol	0.2	0.3	1.8	-0.4	-0.2	0.2	-0.5	0.2	0.6	-0.4	0.8	-0.3	-0.2	1.3
Medication: Omeprazole	2.7	3.3	5.5	-2.3	-2.3	-0.5	-2.0	-2.0	0.9	-2.2	-2.3	-2.0	-0.3	1.3
Medication: Seretide 50 evohaler	0.4	0.5	1.3	0.7	0.7	-0.0	0.5	0.1	1.1	0.3	0.8	0.2	-1.2	-0.8
Mean time to correctly identify matches	2.0	3.8	6.4	-2.1	-1.9	0.6	-2.3	-1.9	-1.5	-2.1	-2.0	-1.9	1.7	-2.5
Heart disease (mother)	0.5	0.6	3.1	-0.8	-0.3	-0.3	-1.0	-0.2	0.3	-0.6	-0.1	-0.3	-1.1	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	0.1	0.3	0.9	0.3	1.3	1.1	0.4	1.0	0.6	0.4	-0.7
Whole body fat mass	0.2	0.7	2.7	-0.2	-0.4	1.2	0.2	1.6	-0.5	0.0	0.9	-0.1	-1.3	0.3
Leg fat mass (right)	0.4	1.4	3.4	-1.5	-1.9	1.6	-1.1	0.8	-1.1	-1.3	0.0	-1.4	-0.6	0.1
Arm predicted mass (right)	0.1	0.6	2.3	0.1	-0.3	1.2	0.9	0.1	-1.5	0.7	1.1	0.6	-0.3	0.8
Pulse rate, automated reading	0.7	2.2	7.1	1.3	2.7	1.1	1.1	0.9	-0.1	1.5	1.6	1.2	-1.6	1.9
Alcohol intake frequency.	0.9	2.0	4.5	-1.0	-1.7	0.4	-1.9	-0.2	-2.1	-1.5	-1.3	-1.6	-1.8	0.9
Comparative height size at age 10	0.1	0.7	3.1	0.4	0.5	0.3	1.1	1.8	-1.2	0.9	0.2	0.7	-0.6	0.1
Number of full sisters	2.5	3.0	5.6	-1.8	-2.2	0.0	-2.2	-0.9	-2.4	-1.5	-2.1	-1.4	-0.7	2.1
Suffer from ‘nerves’	0.4	0.7	3.2	0.1	-0.1	0.2	-0.3	-0.3	-1.6	-0.1	-0.6	-0.3	1.0	-1.8
Overall health rating	2.6	5.6	13.2	-2.7	-3.6	-1.2	-2.8	-1.0	-1.9	-2.8	-3.3	-2.8	-0.4	0.4
Chest pain or discomfort	0.3	0.5	1.7	-0.3	-0.7	-0.9	-0.3	-0.0	-1.1	-0.3	-1.3	-0.5	0.8	0.3
Had major operations	0.4	0.5	1.0	-0.5	-1.0	0.7	-0.9	0.6	-0.8	-0.6	-0.8	-0.7	0.3	0.5
Age at last live birth	0.4	0.5	2.4	0.2	0.6	0.3	0.7	-0.9	1.5	0.1	0.3	0.2	-1.0	0.7
Family relationship satisfaction	1.1	1.4	6.0	0.9	0.7	0.6	1.0	2.5	-0.2	0.9	1.5	1.0	0.1	1.6
Leg pain on walking	2.0	2.5	5.0	-1.9	-2.2	0.2	-1.8	-1.1	-0.5	-2.0	-2.2	-1.9	1.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.4	0.5	0.7	1.6	-0.2	0.4	-0.2	0.7	0.3	0.9	-0.8	0.9
Commuting to job workplace: Car/motor vehicle	2.3	2.6	5.8	2.4	2.4	-0.5	2.0	0.1	-0.2	2.3	0.8	2.1	0.7	1.4
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	4.4	1.7	2.0	0.6	2.0	2.1	1.9	1.7	1.5	1.7	-0.1	0.6
Medication: Aspirin	0.3	0.3	0.7	-0.6	-0.8	-0.4	-0.1	-0.2	0.6	-0.7	-0.8	-0.6	-0.8	-0.5
Supplements: Vitamin C	1.8	2.1	3.8	1.7	1.7	0.6	1.5	1.9	0.5	1.8	1.9	1.7	0.6	-1.0
Knee pain experienced in last month	0.1	0.2	0.7	-0.6	-0.8	-0.0	0.1	0.6	0.2	-0.3	-0.2	-0.3	-0.3	-0.8
Hypertension (Self-reported)	0.9	2.4	7.1	-1.7	-1.9	-1.1	-1.1	-2.7	0.6	-1.5	-2.0	-1.1	1.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	4.7	-1.9	-2.1	-1.0	-2.2	-0.7	0.1	-2.0	-1.5	-1.8	0.8	-0.4
Illnesses of father: Heart disease	1.1	1.5	4.5	-0.8	-0.8	-0.5	-1.0	-1.4	-1.5	-0.9	-1.9	-1.1	-0.1	2.1
Illnesses of siblings: Diabetes	0.6	0.8	1.8	-0.8	-1.3	-1.3	-0.6	-0.7	-0.6	-0.6	-1.2	-0.5	0.9	0.3
Smoking status: Previous	0.6	1.0	6.7	-1.0	-0.0	0.0	0.0	-2.6	0.7	-0.6	-1.1	-0.4	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	6.1	2.3	2.2	0.8	2.2	0.3	0.1	2.5	1.9	2.2	-1.5	0.0
Whole body fat-free mass	0.3	1.9	4.7	1.2	0.6	1.6	1.9	1.3	-0.5	1.6	2.2	1.5	-1.1	0.8
Leg fat-free mass (right)	0.6	3.4	8.8	1.8	1.4	1.9	2.1	2.1	0.4	2.2	3.0	2.2	-1.4	0.2
Arm fat percentage (left)	0.2	0.7	2.9	-0.1	-0.3	1.4	0.0	1.7	0.2	-0.1	0.9	-0.0	-1.5	-0.4
Average weekly red wine intake	0.9	1.3	5.4	0.0	1.0	-1.7	1.4	-1.1	2.3	0.4	0.7	0.7	-0.7	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.8	0.3	0.6	-1.7	0.4	1.1	0.9	0.6	-0.6	0.6	-0.4	-0.5
Mood swings	1.5	2.7	5.2	-1.7	-2.3	0.5	-1.9	-1.0	-1.3	-2.3	-1.6	-2.3	1.2	-0.6
Loneliness, isolation	0.5	0.8	2.4	0.7	0.6	-1.6	0.9	-1.3	-0.3	0.4	-0.8	0.3	0.9	-0.8
Long-standing illness, disability or infirmity	1.2	1.8	5.0	-1.4	-1.8	-1.8	-0.9	-1.0	-0.2	-1.2	-2.2	-1.4	1.0	0.7
Ever had bowel cancer screening	0.6	0.7	3.3	-0.5	-0.3	-0.0	-0.8	-0.8	0.5	-1.1	-1.8	-1.3	-0.1	0.1
Diabetes diagnosed by doctor	0.4	0.6	2.3	-0.5	-0.5	-1.0	-0.0	-1.5	0.6	-0.4	-0.9	-0.4	0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	-0.5	-0.5	0.1	-0.8	-1.0	-1.3	-0.5	-1.0	-0.5	-0.6	-0.3
Friendships satisfaction	1.4	1.7	4.7	1.3	1.3	0.2	1.4	1.8	-0.3	1.1	2.2	1.4	1.0	1.2
Qualifications: nursing, teaching	1.5	2.3	4.8	1.9	2.2	-1.0	2.0	0.1	1.9	1.7	1.1	1.7	-0.7	1.1
Commuting to job workplace: Walk	2.0	2.2	4.4	-2.1	-1.9	-1.0	-1.8	-1.1	-0.9	-1.7	-1.3	-1.7	-0.5	-1.5
Eye problems/disorders: Cataract	1.2	1.4	4.4	1.6	1.5	-0.6	2.1	0.4	0.4	1.7	0.4	1.6	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.8	-0.1	-0.4	-0.2	-0.1	-0.9	0.7	-0.4	-0.1	-0.2	-1.4	-0.7
Medication for cholesterol	0.5	0.8	2.3	1.1	1.1	0.4	0.6	0.8	-0.2	0.5	1.3	0.3	-0.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	8.3	-1.8	-1.6	-0.9	-1.8	-2.8	-1.7	-1.4	-2.9	-1.5	1.3	1.5
Back pain experienced in last month	4.8	7.0	14.8	-3.2	-3.8	0.2	-3.5	-0.9	-2.6	-3.3	-3.3	-3.2	0.2	0.1
Mineral and other dietary supplements	2.7	3.6	7.8	2.1	2.8	-0.6	2.1	1.6	0.9	2.4	2.1	2.3	-0.4	1.8
Breast cancer (self-reported)	0.5	0.6	2.9	-0.3	-0.4	0.0	-1.0	-0.4	-1.7	-0.5	-0.9	-0.8	-0.7	-0.7
Asthma (self-reported)	0.8	1.6	4.2	-1.6	-1.6	0.5	-1.7	-1.0	-1.3	-1.1	-2.1	-1.2	-0.0	0.4
Osteoporosis (self-reported)	1.1	1.3	4.8	-1.1	-1.1	-0.2	-1.7	-0.7	-2.2	-1.1	-0.7	-1.3	0.4	-0.8
Osteoarthritis (self-reported)	0.2	0.3	1.8	-0.2	-0.4	-1.3	0.1	0.1	0.6	-0.3	0.6	-0.3	0.2	0.2
Medication: Aspirin	0.5	0.6	1.5	-0.8	-1.0	0.0	-0.3	-0.3	0.8	-1.0	-0.9	-0.9	-1.2	-0.6
Medication: Gliclazide	0.3	0.4	1.5	-0.1	0.3	-1.2	-0.2	-1.0	-0.6	0.3	-0.1	-0.0	-0.7	0.6
Illnesses of father: None of the above (group 1)	2.3	2.8	5.8	1.5	1.7	-1.4	1.6	1.5	2.3	1.6	2.4	1.9	0.5	-1.1
Smoking status: Current	0.4	0.7	3.2	-0.4	-1.0	0.7	-0.4	0.9	-1.8	-0.0	-0.1	-0.2	-0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.0	1.9	2.0	0.2	1.2	1.5	-0.8	1.6	1.9	1.5	-0.6	0.5
Whole body water mass	0.4	2.1	5.4	1.2	0.7	1.6	1.9	1.3	-0.4	1.6	2.3	1.6	-1.0	0.7
Leg predicted mass (right)	0.6	3.3	8.5	1.7	1.4	1.8	2.0	2.0	0.3	2.1	2.9	2.1	-1.4	0.2
Arm fat mass (left)	0.2	0.9	2.8	0.0	-0.3	1.6	0.4	1.7	-0.2	0.3	1.3	0.2	-1.5	0.2
Number of self-reported non-cancer illnesses	0.5	0.8	2.3	-0.9	-1.2	-0.1	-0.8	-1.1	-0.4	-0.6	-1.5	-0.7	0.6	0.8
Average weekly champagne plus white wine intake	0.7	1.0	3.5	0.9	1.1	1.0	0.4	1.9	-0.6	1.0	1.1	0.9	1.0	-0.5
Miserableness	0.2	0.4	1.0	-0.5	-0.7	-0.9	-0.5	-0.3	-0.6	-0.4	-0.9	-0.3	1.0	-0.2
Guilty feelings	0.7	1.0	3.5	-0.5	-0.6	-1.4	-0.2	-1.9	-1.1	-0.3	-0.4	-0.3	1.7	-0.2
Wears glasses or contact lenses	1.9	2.2	5.9	-1.6	-1.4	-2.4	-1.0	-0.0	-0.3	-1.7	-2.4	-1.6	0.5	1.2
Ever taken oral contraceptive pill	1.8	2.0	5.8	1.0	0.8	2.4	1.0	2.0	1.1	1.4	1.6	1.7	0.9	0.4
Hearing aid user	1.1	1.2	2.5	1.5	1.0	-0.6	1.4	1.2	0.2	1.0	1.0	0.8	-1.6	1.2
Mother’s age at death	0.1	0.2	1.6	-0.2	0.3	0.1	-0.1	-0.2	0.4	-0.3	0.1	-0.1	1.3	0.2
Financial situation satisfaction	0.4	0.4	1.6	0.4	0.5	0.0	0.4	0.8	0.6	0.7	0.6	0.9	0.2	-1.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.4	0.0	-0.1	-0.8	0.6	-0.1	-0.8	0.1	-1.2	0.0	-0.9	0.1
Commuting to job workplace: Public transport	3.2	3.9	6.0	-2.4	-2.1	1.4	-2.3	-1.1	-1.6	-2.3	-1.4	-2.1	1.7	-2.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.5	1.0	0.4	0.2	0.9	0.2	0.1	0.7	-0.4	0.7	-0.5	1.2
Medication: Blood pressure	0.7	1.4	2.8	-1.7	-1.7	0.7	-1.1	-1.0	0.5	-1.2	-1.3	-0.9	1.3	1.1
Pain type(s) experienced in last month: Hip pain	8.3	10.5	20.2	-4.0	-4.0	-0.4	-4.5	-2.2	-3.8	-3.9	-3.2	-4.0	-1.5	-0.2
Supplements: Fish oil (including cod liver oil)	3.2	4.2	8.2	-2.2	-2.9	1.3	-2.5	-1.8	-1.7	-2.5	-2.2	-2.5	-1.0	-1.0
High cholesterol (Self-reported)	0.8	1.4	3.2	-1.6	-1.8	0.5	-1.0	-0.2	0.8	-1.4	-1.6	-1.4	1.1	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.5	0.4	0.4	-0.8	0.5	-0.9	1.1	0.8	0.1	1.2	1.2	1.2
Medication: Paracetamol	2.4	3.7	7.1	-2.1	-2.0	-1.8	-2.4	-1.5	-1.8	-2.2	-2.7	-2.3	-0.3	-0.5
Medication: Lisinopril	0.3	0.4	1.7	0.1	0.4	-1.1	-0.5	-0.4	-1.3	0.3	0.7	0.3	0.0	-0.6
Medication: Atorvastatin	0.8	1.0	2.5	-1.6	-1.6	0.3	-1.1	-0.1	-0.9	-1.1	-0.7	-1.1	-1.0	0.1
Illnesses of father: High blood pressure	0.6	0.8	2.7	-0.9	-1.0	0.4	-0.5	-1.0	-0.7	-0.8	-1.6	-1.1	0.6	-0.3
Alcohol drinker status: Never	0.8	0.9	3.2	-0.2	-1.0	0.9	-1.3	1.5	-1.8	-0.6	-0.0	-0.7	-0.5	0.4
Ever smoked	0.5	0.9	3.1	-1.1	-0.5	-0.7	0.1	-1.7	1.1	-0.9	-1.0	-0.8	-0.7	0.9
Basal metabolic rate	0.3	1.7	4.5	0.9	0.4	1.7	1.6	1.4	-0.6	1.3	2.1	1.3	-1.2	0.7
Leg fat percentage (left)	1.2	4.5	10.7	-2.7	-3.3	1.6	-2.6	0.3	-2.1	-2.7	-1.2	-2.9	-0.7	-0.1
Arm fat-free mass (left)	0.2	0.9	2.2	0.3	-0.3	1.5	0.9	0.6	-1.5	0.8	1.4	0.6	-0.8	0.7
Number of operations (self-reported)	1.0	1.5	6.0	-0.9	-1.2	0.1	-1.0	-0.9	-1.7	-0.8	-1.2	-1.0	0.7	2.4
Average weekly beer plus cider intake	0.4	0.6	1.8	-0.5	-0.9	1.3	-0.8	0.3	-0.5	-0.4	0.4	-0.1	-1.1	1.2
Irritability	1.8	3.1	7.7	2.0	1.7	0.9	1.9	0.9	2.2	1.8	2.8	2.1	1.1	0.3
Risk taking	0.5	0.7	2.7	-0.6	-1.1	0.5	-0.7	-0.2	-1.1	-0.7	-0.3	-0.6	-1.6	0.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.1	0.5	0.6	-0.2	1.1	0.7	2.0	0.4	-0.4	0.4	-1.4	0.1
Fractured/broken bones in last 5 years	0.4	0.5	2.9	-0.3	-0.2	-1.7	-0.3	-1.1	-0.4	-0.4	-0.8	-0.2	-0.6	-0.3
Age started oral contraceptive pill	0.6	0.7	1.9	0.1	0.7	-0.1	0.8	0.8	1.2	0.5	0.9	0.5	-1.2	-1.4
Diastolic blood pressure, automated reading	0.3	1.0	8.6	-0.0	-0.4	1.1	0.2	0.9	-0.4	0.2	-0.0	0.1	-2.9	-0.1
Ever depressed for a whole week	1.5	1.9	4.2	-1.4	-1.6	-0.3	-1.5	-2.0	-1.1	-1.5	-2.0	-1.5	0.6	0.5
Unable to work because of sickness or disability	1.7	2.2	8.7	-0.8	-1.0	-3.0	-1.0	-1.1	-1.6	-0.9	-2.6	-1.0	-1.0	-0.2
Commuting to job workplace: Cycle	0.2	0.3	1.1	0.6	0.6	1.0	0.6	-0.1	0.5	0.4	0.2	0.4	0.6	-0.1
Myopia	0.1	0.2	0.7	-0.3	-0.0	-0.6	0.1	-0.5	0.2	0.1	0.3	0.4	0.8	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.5	1.2	1.4	0.4	0.6	2.1	-0.4	0.9	2.1	0.7	-1.0	-0.5
Cholesterol lowering medication	0.8	1.2	2.6	-1.6	-1.6	-0.8	-1.0	-0.5	0.2	-1.3	-1.5	-1.0	-0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	4.2	5.2	9.4	-3.1	-3.0	-0.8	-2.7	-2.1	0.4	-3.0	-2.9	-2.8	0.2	0.4
Pain experienced in last month	0.9	1.5	4.0	1.4	2.0	0.0	1.6	0.3	0.1	1.4	1.1	1.2	-1.5	1.1
Supplements: Calcium	2.2	2.4	4.5	-1.8	-1.8	-0.1	-1.8	-1.0	-1.2	-1.8	-2.1	-1.8	0.9	-1.5
Basal cell carcinoma (self-reported)	0.3	0.4	2.4	-0.1	-0.3	-0.6	-0.2	0.0	0.8	0.0	0.7	0.2	1.5	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.2	-0.3	0.3	-0.1	-0.1	-0.7	-0.2	-0.6	-0.3	0.5	0.6
Deep venous thrombosis (DVT) (self-reported)	3.5	4.5	8.9	-2.7	-2.8	0.7	-3.0	-1.9	-1.4	-2.6	-2.2	-2.6	-0.6	0.8
Heart disease (siblings)	2.3	2.9	5.3	-2.1	-2.2	-1.5	-2.3	-1.0	-0.7	-2.2	-1.9	-2.2	-0.1	-0.5
Alcohol drinker status: Previous	0.7	0.8	3.7	-0.5	-0.5	0.5	-0.7	-0.8	-1.1	-0.3	-0.9	-0.4	-1.9	1.3
Pack years of smoking	1.3	1.9	10.7	1.6	1.1	-0.1	1.2	0.3	0.4	1.6	0.0	1.5	-0.8	3.3
Impedance of whole body	0.1	0.7	5.2	0.0	1.0	-2.3	-0.2	0.0	-0.2	0.1	-1.3	-0.2	0.1	-0.3
Leg fat mass (left)	0.4	1.4	3.3	-1.4	-1.8	1.7	-1.1	1.0	-1.2	-1.2	0.2	-1.3	-0.9	0.2
Arm predicted mass (left)	0.2	0.8	2.2	0.1	-0.5	1.5	0.8	0.6	-1.4	0.5	1.2	0.4	-0.9	0.7