TWAS hub - UBASH3B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0267	0.0084	0.00019	0.018	0.014	0.021	0.014	0.020	1.3e-06	1.2e-05	1.9e-07	1.4e-05	3.3e-07
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0760	0.0327	0.00430	-0.002	0.013	-0.001	NA	-0.002	6.3e-01	1.2e-02	4.4e-01	NA	9.4e-01
3	TCGA	Thyroid Carcinoma	0.1350	0.0480	0.00063	-0.001	0.035	0.018	NA	0.005	4.0e-01	2.1e-04	5.8e-03	NA	1.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Leg fat percentage (left)	7.4	26.9	55.4	-7.4	2.3	4.5
Leg fat percentage (right)	6.6	23.9	46.6	-6.8	2.5	4.3
Diastolic blood pressure, automated reading	6.0	18.5	21.4	-3.6	4.6	4.6
Leg fat mass (left)	5.9	23.0	45.7	-6.8	1.9	4.4
Waist circumference	5.7	20.7	35.3	-5.9	2.3	4.6
Leg fat mass (right)	5.5	21.2	40.8	-6.4	2.1	4.3
Body mass index (BMI)	5.3	22.7	43.2	-6.6	2.0	4.6
Blood White Count	5.1	37.7	46.9	-6.8	4.8	6.5
Health satisfaction	5.1	6.6	7.2	-2.6	2.4	2.7
Body fat percentage	4.9	19.4	40.4	-6.4	1.7	3.8
Cardiovascular Disease	4.8	16.0	23.6	-1.7	4.6	4.9
Arm fat percentage (right)	4.6	18.2	34.2	-5.8	1.6	4.2
Qualifications: None of the above	4.4	9.5	16.2	-4.0	1.6	3.1
Arm fat mass (right)	4.4	18.1	33.5	-5.8	1.6	4.3
Whole body fat mass	4.3	18.0	36.1	-6.0	1.5	3.9
Arm fat percentage (left)	4.2	16.6	33.2	-5.8	1.2	3.9
Mean Putamen Volume	4.0	4.6	10.6	3.2	-0.6	-1.7
Overall health rating	4.0	8.5	10.2	-2.5	3.2	3.0
LDL Cholesterol	3.9	6.2	16.1	-4.0	0.1	1.5
Systolic blood pressure, automated reading	3.9	11.3	19.9	-1.2	4.5	3.5
High blood pressure	3.9	10.8	18.0	-0.8	3.7	4.2
Alcohol usually taken with meals	3.9	6.3	10.4	2.2	-2.0	-3.2
Hip circumference	3.9	16.6	30.9	-5.6	1.6	4.0
Arm fat mass (left)	3.9	16.1	30.5	-5.5	1.4	4.0
Trunk fat percentage	3.8	15.0	33.3	-5.8	1.2	3.2
Hypertension (Self-reported)	3.8	10.5	17.8	-0.7	3.6	4.2
Trunk fat mass	3.6	15.3	31.9	-5.7	1.1	3.6
Mouth/teeth dental problems: Loose teeth	3.6	4.2	6.1	-1.8	2.5	1.8
Medication: Blood pressure	3.6	6.8	11.2	0.1	3.3	3.0
Cholesterol lowering medication	3.6	5.2	9.4	-1.5	3.1	2.0
Systolic Blood Pressure	3.5	17.3	39.7	0.4	6.3	3.5
Medication: Simvastatin	3.5	5.1	9.2	-2.0	3.0	1.4
Wheeze or whistling in the chest in last year	3.5	6.2	10.4	-3.2	0.7	2.8
Medication: Bendroflumethiazide	3.4	5.2	8.5	-1.8	1.9	2.9
Medication: Amlodipine	3.2	4.5	8.0	0.2	2.8	2.4
Vascular/heart problems diagnosed by doctor	3.2	8.7	12.9	1.3	-3.4	-3.6
BMI	3.1	17.7	36.1	-6.0	0.8	4.0
Medication: Ramipril	3.0	3.8	6.9	-0.9	2.6	1.9
Average weekly red wine intake	2.9	4.3	6.6	2.1	-1.3	-2.6
Medication for cholesterol	2.9	4.4	7.5	-0.1	-2.7	-2.4
Had other major operations	2.7	3.4	6.8	-1.7	0.7	2.6
Weight	2.7	13.5	25.7	-5.1	1.0	3.7
Ever had bowel cancer screening	2.7	3.2	7.1	1.6	0.1	-2.7
Illnesses of father: Heart disease	2.6	3.6	7.8	-1.0	2.8	1.4
Hand grip strength (right)	2.4	6.5	11.0	0.8	-2.8	-3.3
Qualifications: A levels/AS levels or equivalent	2.4	5.3	6.2	2.5	-2.3	-2.1
Qualifications: College or University degree	2.4	7.6	10.2	2.4	-2.6	-3.2
High cholesterol (Self-reported)	2.4	4.3	6.3	-1.7	2.5	1.9
Bipolar Disorder or Schizophrenia	2.3	5.6	12.9	1.3	-1.5	-3.6
Schizophrenia (2018)	2.3	4.7	12.7	0.6	-1.0	-3.6
Number of treatments/medications taken	2.3	4.1	8.3	-1.3	1.5	2.9
Medication for hormone replacement therapy	2.3	2.6	5.2	0.8	-2.3	-1.4
Emphysema/chronic bronchitis	2.3	2.6	5.6	-0.8	1.2	2.4
Schizophrenia (2014)	2.2	4.8	11.2	-0.4	-1.8	-3.3
Father’s age at death	2.2	2.9	8.1	0.2	-2.8	-0.8
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	7.3	-2.7	0.0	1.1
Qualifications: nursing, teaching	2.1	3.2	5.1	2.3	-1.5	-1.5
Qualifications: CSEs or equivalent	2.0	2.6	7.4	-2.7	-0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	7.0	2.6	-1.5	-0.6
Medication: Blood pressure	2.0	3.6	5.8	-0.2	2.2	2.4
Depression (self-reported)	1.9	2.2	4.7	2.2	-1.3	-0.6
Medication: Ventolin 100micrograms inhaler	1.9	2.4	3.8	-1.1	1.5	2.0
Medication: Seretide 50 evohaler	1.9	2.2	5.6	-0.8	0.8	2.4
Supplements: Vitamin C	1.9	2.2	3.9	-1.4	1.0	2.0
Depression (Nagel 2018)	1.8	2.7	5.3	-2.3	0.9	1.4
Taking other prescription medications	1.8	2.8	3.8	-1.4	2.0	1.6
Medication: Levothyroxine sodium	1.8	3.1	3.9	-1.7	2.0	1.5
Medication: Cholesterol lowering	1.8	2.8	3.0	-1.7	1.6	1.7
Birth weight	1.8	3.9	7.5	-0.1	-2.7	-2.1
Shortness of breath walking on level ground	1.8	2.1	3.3	-1.5	0.9	1.8
Leg pain on walking	1.8	2.2	3.1	-1.0	1.6	1.8
Friendships satisfaction	1.8	2.2	6.1	2.5	0.1	-0.7
Ever depressed for a whole week	1.8	2.3	5.7	-0.7	2.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	7.3	-1.1	1.8	2.7
Pain all over the body in last month	1.7	1.9	4.0	0.6	1.1	2.0
Fluid intelligence score	1.7	3.5	5.7	2.4	-1.1	-1.9
Impedance of arm (left)	1.7	7.9	12.3	3.5	-2.4	-2.4
High blood pressure (siblings)	1.7	2.4	4.2	-0.6	1.6	2.0
Neuroticism (2016)	1.6	2.2	5.0	0.9	-2.2	-1.0
Hand grip strength (left)	1.6	4.2	9.4	0.3	-1.8	-3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	2.9	-1.2	1.7	1.4
Serious illness, injury or assault to yourself	1.6	1.9	3.7	1.0	1.9	-1.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	4.0	0.7	-2.0	-1.8
Medication: Aspirin	1.6	2.1	3.2	-1.5	1.8	0.8
Medication: Aspirin	1.6	2.0	2.9	-1.3	1.7	1.3
Blood Platelet Count	1.5	17.9	47.1	-6.9	-1.7	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.8	1.3	-0.7	-1.7
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.1	-1.2	-1.4	-1.1
Migraine (self-reported)	1.4	1.7	3.0	-0.0	-1.5	-1.7
Long-standing illness, disability or infirmity	1.4	2.2	6.2	-0.2	2.5	0.5
Number of self-reported non-cancer illnesses	1.4	2.4	4.6	-0.9	2.1	1.3
Reaction Time	1.3	2.4	3.6	1.8	1.9	0.5
HDL Cholesterol	1.3	2.1	6.0	-2.4	0.7	-0.1
Severe depression (siblings)	1.3	1.5	2.2	1.3	-1.5	-0.8
Medication: Atenolol	1.3	1.6	2.5	-1.5	0.2	1.6
Worrier / anxious feelings	1.3	2.4	4.1	1.0	-1.5	-2.0
Exposure to tobacco smoke outside home	1.3	1.7	4.1	-0.8	-0.6	2.0
Age at first live birth	1.3	2.4	5.8	2.4	-0.9	-0.7
Medication: Omeprazole	1.3	1.5	3.1	1.8	0.5	1.1
Number of full sisters	1.3	1.6	4.5	-0.4	2.1	-0.1
Loneliness, isolation	1.3	1.8	3.3	-1.8	0.9	1.2
Arm predicted mass (left)	1.3	6.8	11.4	-3.4	0.9	2.9
Depressed Affect (Nagel 2018)	1.2	2.5	3.3	-1.8	1.8	1.0
Prospective memory result	1.2	1.5	3.6	-0.1	1.0	1.9
Hair/balding pattern: Pattern 4	1.2	2.8	6.5	-1.3	0.4	2.5
Blood clot in the leg (DVT)	1.2	1.5	2.2	1.0	-1.5	-1.2
Chest pain or discomfort	1.2	1.7	3.9	-1.1	2.0	0.4
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.2	1.5	-1.1	-1.0
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.3	-1.5	0.4	1.5
Commuting to job workplace: Cycle	1.2	1.4	2.3	1.3	-0.4	-1.5
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.9	-1.7	1.0	0.9
HbA1C	1.1	1.2	2.8	-0.9	-0.3	-1.7
Triglycerides	1.1	1.8	3.0	-1.5	0.2	1.7
Maternal smoking around birth	1.1	1.6	3.4	0.2	-1.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.7	-0.9	1.4	2.2
Heart attack	1.1	1.4	2.7	-1.7	0.8	0.9
Impedance of arm (right)	1.1	5.1	8.1	2.8	-2.0	-1.8
Gout (self-reported)	1.1	1.5	3.2	-1.0	-0.6	1.8
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.2	-0.4	2.3	0.9
Mean time to correctly identify matches	1.1	2.1	4.0	1.4	2.0	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.5	-1.9	-0.6	-0.1
Arm fat-free mass (left)	1.1	5.8	9.5	-3.1	0.8	2.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	0.9	-1.5	-1.1
Lupus	1.0	1.5	2.9	-0.3	1.7	1.2
Primary Biliary Cirrhosis	1.0	1.4	3.7	-1.9	-0.8	-0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	-0.0	1.2	1.4
Fed-up feelings	1.0	1.8	4.3	-2.1	0.7	0.7
Stomach or abdominal pain in last month	1.0	1.2	3.0	0.6	-0.6	-1.7
Pulse rate	1.0	1.7	3.9	-0.9	0.5	2.0
Neck or shoulder pain in last month	1.0	1.4	3.5	0.2	0.8	1.9
Ever taken oral contraceptive pill	1.0	1.1	2.3	0.2	-1.0	1.5
Illnesses of father: High blood pressure	1.0	1.2	3.7	0.2	1.9	-0.3
Basal metabolic rate	1.0	5.4	8.2	-2.9	0.1	2.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.3	1.5	-0.3	1.2
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.4	1.9	-0.2	-2.1
Alzheimer’s Disease (in father)	0.9	1.0	2.1	0.8	1.4	0.6
Body Mass Index (BMI) (2010)	0.9	1.3	3.1	-1.8	0.8	0.0
Chronotype (morning person)	0.9	2.1	3.2	1.8	-1.4	-1.1
Diabetes (mother)	0.9	1.1	3.1	-0.2	0.4	1.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.5	1.6	-0.2	-0.8
Supplements: Glucosamine	0.9	1.1	2.8	1.7	-0.6	0.4
Illnesses of siblings	0.9	1.3	3.1	0.7	0.5	-1.8
Alcohol intake versus 10 years previously	0.9	1.3	3.0	-0.7	0.6	1.7
Medication: Lansoprazole	0.9	1.0	2.8	0.0	-1.7	-0.5
Eye problems/disorders: None of the above	0.9	1.0	1.8	-1.3	-0.1	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.8	0.2	1.7	-0.7
Arm predicted mass (right)	0.9	4.4	7.3	-2.7	0.5	2.4
Back pain experienced in last month	0.9	1.4	3.2	-1.8	-0.3	0.9
Alcohol drinker status: Never	0.9	1.1	1.6	0.4	1.2	-1.2
Unable to work because of sickness or disability	0.9	1.1	2.3	-0.3	1.0	1.5
Basal cell carcinoma (self-reported)	0.9	1.1	2.2	1.5	-0.7	-0.8
Fasting Glucose	0.8	0.9	2.8	0.1	-0.1	-1.7
Hypothyroidism (self reported)	0.8	1.9	5.6	-0.1	2.4	-0.4
Lung FVC	0.8	4.2	8.0	2.8	2.0	-0.8
Ever had hysterectomy (womb removed)	0.8	0.9	1.6	-1.3	-1.0	-0.1
Medication: Co-codamol	0.8	0.9	1.4	-1.0	0.4	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	-1.2	-0.0	1.3
Headache pain in last month	0.8	1.4	3.2	-0.6	-1.8	-0.9
Arm fat-free mass (right)	0.8	4.1	6.5	-2.5	0.5	2.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.9	-1.0	-0.1	1.4
Asthma (self-reported)	0.8	1.6	3.0	-1.7	-0.0	1.4
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	0.1	-1.5	-0.9
Medication: Lisinopril	0.8	1.0	2.0	-0.9	1.4	0.6
Impedance of whole body	0.8	4.2	6.1	2.5	-1.2	-2.3
Bipolar Disorder (2018)	0.7	1.1	1.2	1.1	-1.1	-1.0
Major Depression (MDD)	0.7	0.8	1.5	-1.2	-0.9	0.4
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.2	0.7	-1.0	-1.8
Age at First Birth	0.7	1.0	1.5	0.4	-1.2	-1.2
Bipolar Disorder (2011)	0.7	0.7	2.0	1.4	0.0	0.0
Lung FEV1/FVC ratio	0.7	3.6	9.5	-1.2	-3.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	0.1	0.8	1.4
Medication: Metformin	0.7	1.0	2.2	-1.5	-0.2	0.9
Forced vital capacity (FVC)	0.7	2.7	6.6	2.6	0.1	-1.2
Forced vital capacity (FVC), Best measure	0.7	2.6	7.1	2.7	-0.3	-0.8
Comparative body size at age 10	0.7	1.8	2.9	-1.5	-1.7	-0.5
Medication: Ibuprofen	0.7	0.8	1.3	-1.1	0.1	1.1
Eye problems/disorders: Cataract	0.7	0.9	2.2	1.5	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.2	1.8	0.9	0.6
Leg predicted mass (right)	0.7	3.5	5.5	-2.3	-0.4	2.2
Supplements: Calcium	0.7	0.7	1.6	0.6	-0.5	-1.2
Alzheimer’s Disease (including proxy)	0.6	0.8	1.8	0.2	1.4	0.8
Ovarian Cancer	0.6	0.9	2.2	-1.5	0.6	0.1
Leg fat-free mass (left)	0.6	3.3	5.5	-2.1	-0.1	2.4
Multivitamins +/- minerals	0.6	0.8	2.4	1.6	-0.1	-0.2
Leg predicted mass (left)	0.6	3.4	5.5	-2.2	-0.2	2.3
Time employed in main current job	0.6	0.7	2.0	-0.2	-0.0	1.4
Noisy workplace	0.6	0.8	1.7	0.6	-1.3	-0.6
Asthma	0.6	1.2	2.6	-1.6	-0.0	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.5	1.2	-0.8	-0.2
Worry too long after embarrassment	0.6	0.9	1.3	1.1	-0.4	-1.2
Family relationship satisfaction	0.6	0.7	1.9	0.4	-0.0	-1.4
Whole body fat-free mass	0.6	3.3	5.6	-2.0	-0.4	2.4
Leg fat-free mass (right)	0.6	3.5	5.6	-2.4	-0.4	2.1
Whole body water mass	0.6	3.3	6.1	-1.9	-0.2	2.5
Average weekly champagne plus white wine intake	0.6	0.8	2.0	0.2	0.7	-1.4
Average weekly beer plus cider intake	0.6	0.9	1.4	1.2	0.5	1.0
Age started oral contraceptive pill	0.6	0.7	1.1	1.0	-1.1	-0.1
Worry (Nagel 2018)	0.5	1.2	3.3	1.8	-0.4	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	0.7	-0.8	0.9	0.6
Heel T-Score	0.5	4.1	6.5	-0.5	2.4	2.5
Average weekly spirits intake	0.5	0.6	1.1	-0.3	-0.7	-1.0
Relative age of first facial hair	0.5	1.0	1.6	-0.9	-0.8	1.2
Current tobacco smoking	0.5	0.9	1.6	1.2	-0.0	1.0
Relative age voice broke	0.5	0.8	1.6	-0.0	-1.3	0.8
High blood pressure (mother)	0.5	0.7	1.2	-0.1	1.1	0.9
Number of incorrect matches in round	0.5	0.8	1.1	1.1	-0.7	-1.0
Nervous feelings	0.5	0.9	2.0	1.4	-0.8	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.7	0.8	-1.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.5	0.6	1.2	0.1
Mouth/teeth dental problems	0.5	0.7	1.9	1.4	-0.6	0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.1	2.0	-0.5	-0.9
Standing height	0.5	4.6	7.3	2.7	-2.1	-1.4
Birth weight of first child	0.5	1.0	2.1	-0.8	-1.4	-0.4
Pulse wave reflection index	0.5	0.6	0.9	0.6	0.8	-1.0
Number of children fathered	0.5	0.5	1.0	0.8	-1.0	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	1.7	0.8	-0.5	-1.3
Pulse rate, automated reading	0.5	1.6	3.7	-1.9	-0.5	1.0
Comparative height size at age 10	0.5	2.9	6.0	2.5	-1.6	-0.3
Had major operations	0.5	0.6	1.4	-0.5	0.4	1.2
Medication: Gliclazide	0.5	0.6	1.4	-0.3	1.2	-0.5
Smoking status: Current	0.5	0.8	1.3	1.0	-0.2	1.1
Financial situation satisfaction	0.5	0.7	1.3	-1.2	0.4	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	0.4	-0.5	-1.1
Medication: Atorvastatin	0.5	0.6	1.5	-0.2	0.4	1.2
Heart disease (siblings)	0.5	0.7	1.6	0.4	-1.3	-0.4
Rheumatoid Arthritis	0.4	0.6	0.9	-0.3	-1.0	0.8
Blood Eosinophil Count	0.4	3.2	5.5	-2.3	1.0	1.8
Smoking Status	0.4	0.9	2.5	0.5	0.2	1.6
Allergy or Eczema	0.4	1.0	1.5	0.8	1.2	0.9
Angina	0.4	0.6	1.0	-1.0	0.8	0.4
Age when periods started (menarche)	0.4	0.9	2.0	-1.4	0.9	0.0
Financial difficulties in last 2 years	0.4	0.6	0.6	-0.8	0.8	0.8
Trunk fat-free mass	0.4	2.4	5.3	-1.4	-0.3	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.0	2.0	-0.4	-0.3
Trunk predicted mass	0.4	2.2	4.9	-1.3	-0.4	2.2
Breastfed as a baby	0.4	0.5	0.9	-1.0	-0.5	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.4	1.2	0.4	-0.4
Loud music exposure frequency	0.4	0.4	1.2	0.2	0.0	-1.1
Suffer from ‘nerves’	0.4	0.7	1.6	1.3	-0.5	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.5	-0.8	0.8
Commuting to job workplace: Walk	0.4	0.4	1.2	-0.2	-0.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.6	-0.4	1.3	-0.0
Mineral and other dietary supplements	0.4	0.6	0.8	-0.6	0.8	-0.9
Breast cancer (self-reported)	0.4	0.5	0.9	-0.8	0.0	1.0
Guilty feelings	0.4	0.7	1.1	0.9	1.0	-0.3
Wears glasses or contact lenses	0.4	0.4	1.2	-0.1	1.1	-0.4
Hearing aid user	0.4	0.5	1.2	-0.5	1.1	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	1.1	-0.5	-0.1
Medication: Paracetamol	0.4	0.6	0.9	-1.0	-0.6	0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	-0.8	-0.5	-0.7
Crohns Disease (2017)	0.3	0.7	1.5	-1.2	-0.4	0.5
Ulcerative Colitis (UC)	0.3	0.6	1.4	-0.5	1.2	0.1
Breast Cancer	0.3	0.7	2.0	1.4	-0.3	-0.1
Ulcerative Colitis	0.3	0.4	1.0	-0.3	1.0	0.2
Waist Hip Ratio (WHR)	0.3	1.3	3.4	-0.3	0.6	1.8
Respiratory disease	0.3	0.6	1.3	-0.4	0.7	1.1
Neuroticism	0.3	0.8	1.8	0.4	1.3	0.5
Pack years adult smoking proportion	0.3	0.4	0.7	-0.2	0.9	0.7
Impedance of leg (right)	0.3	1.4	2.5	1.6	0.2	-1.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.4	0.6	0.7	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.0	0.8	1.0	0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.9	0.3	0.5
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-0.1	-1.0	-0.4
Falls in the last year	0.3	0.4	0.7	0.6	-0.3	0.8
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	0.0	0.7	-0.9
Angina (self-reported)	0.3	0.3	0.9	-0.9	0.4	0.1
Age at last live birth	0.3	0.5	1.3	1.1	-0.3	-0.1
Osteoarthritis (self-reported)	0.3	0.4	0.6	-0.6	0.4	-0.8
Mother’s age at death	0.3	0.4	0.7	-0.3	-0.6	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	-0.2	0.1	1.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	0.0	0.7	-0.5
Height	0.2	4.3	11.6	3.4	-0.7	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.6	-0.9	0.4
Sensitivity / hurt feelings	0.2	0.3	0.8	0.9	0.2	-0.4
Vitamin and mineral supplements	0.2	0.3	0.5	-0.2	-0.6	-0.7
Supplements: Zinc	0.2	0.2	0.5	0.7	-0.1	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.8	-0.3	0.3
Allergy	0.2	0.4	0.6	-0.6	-0.4	-0.8
Diabetes (self-reported)	0.2	0.4	0.6	-0.5	-0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.9	-0.4	0.1
Neuroticism score	0.2	0.4	0.8	0.2	0.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	-0.5	1.0	-0.2
Happiness	0.2	0.3	0.3	0.5	0.5	0.4
Lung cancer (father)	0.2	0.3	0.5	0.4	0.4	0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.7	0.4	0.2
Length of working week for main job	0.2	0.2	0.4	0.7	-0.4	0.1
Exposure to tobacco smoke at home	0.2	0.3	0.5	-0.6	0.1	0.7
Peak expiratory flow (PEF)	0.2	0.4	1.0	0.1	-0.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.5	0.1	-0.5
Pulse wave peak to peak time	0.2	0.2	0.3	-0.6	-0.5	-0.3
Medication: Allopurinol	0.2	0.2	0.6	-0.3	0.0	0.8
Knee pain experienced in last month	0.2	0.3	0.8	0.2	0.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.6	0.3	0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.9	-0.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.5	-0.6	0.2
Osteoporosis (self-reported)	0.2	0.3	0.7	0.0	0.4	0.8
Ever smoked	0.2	0.3	0.7	0.2	-0.8	0.5
Number of operations (self-reported)	0.2	0.3	0.4	-0.5	0.5	0.6
Irritability	0.2	0.3	0.5	-0.3	-0.7	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.2	0.6	-0.4
Myopia	0.2	0.3	0.7	0.4	0.8	0.2
Pain experienced in last month	0.2	0.4	0.6	0.8	0.3	-0.8
Pack years of smoking	0.2	0.2	0.4	-0.2	0.6	0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.6	0.4	0.7	-0.0
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.6	0.1	-0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-0.9	0.4	-0.1
Prostate Cancer	0.1	0.2	0.2	-0.5	-0.3	0.5
Crohns Disease (2012)	0.1	0.2	0.4	-0.6	-0.0	-0.6
Blood Red Count	0.1	0.6	1.6	0.3	-1.3	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.4	-0.3	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.7	0.3	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.5	0.4	0.2
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.1	0.1	0.6
Average weekly fortified wine intake	0.1	0.1	0.1	-0.3	-0.2	0.3
Sitting height	0.1	0.4	1.0	1.0	0.5	0.2
Impedance of leg (left)	0.1	0.7	1.6	0.6	-0.2	-1.3
Number of live births	0.1	0.1	0.3	-0.2	0.2	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	0.6	-0.0	0.0
Illnesses of mother	0.1	0.1	0.2	0.4	-0.5	0.0
Tense / ‘highly strung’	0.1	0.2	0.3	0.1	-0.5	-0.5
Medication: Paracetamol	0.1	0.2	0.3	-0.4	-0.3	0.6
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	-0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	0.3	0.3	0.4
Heart disease (mother)	0.1	0.1	0.1	-0.3	0.2	0.4
Smoking status: Previous	0.1	0.2	0.4	-0.6	0.3	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.0	-0.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	0.4	0.1
Miserableness	0.1	0.2	0.4	0.7	0.5	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.4	-0.6	0.3	-0.1
Risk taking	0.1	0.2	0.4	-0.1	-0.3	-0.7
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.4	0.2	0.4
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.2	-0.5	-0.4
Hair Pigment	0.0	0.9	1.8	-1.3	1.0	-0.1
Tanning	0.0	0.4	1.0	1.0	0.2	0.4
Diabetes (father)	0.0	0.1	0.2	0.2	0.0	-0.4
Past tobacco smoking	0.0	0.1	0.1	0.3	0.2	-0.3
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.2	0.2	0.0
Had menopause	0.0	0.0	0.1	-0.1	-0.3	-0.2
Number of full brothers	0.0	0.1	0.1	0.3	-0.1	-0.2
Alcohol intake frequency.	0.0	0.1	0.1	-0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.1	0.2	0.4
Mood swings	0.0	0.0	0.1	-0.3	0.0	-0.2

Hub : Genes

UBASH3B

Models

Trait associations