TWAS hub - UBE2H

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Male)	0.0709	0.0976	0.28000	0.000	NA	-0.010	NA	0.008	3.2e-01	NA	6.3e-01	NA	2.1e-01
2	GTEx	Breast Mammary Tissue (Female)	0.1330	0.0834	0.07900	-0.005	NA	-0.009	NA	0.003	4.9e-01	NA	7.4e-01	NA	2.5e-01
3	GTEx	Whole Blood	0.0810	0.0300	0.00180	0.037	NA	0.039	NA	0.021	2.1e-04	NA	1.5e-04	NA	4.8e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.1822	0.0475	0.00003	0.128	0.019	0.123	0.130	0.115	3.7e-16	0.00130	1.7e-15	2.1e-16	1.5e-14
5	YFS	Blood	0.0277	0.0104	0.00093	0.016	0.006	0.014	0.015	0.020	3.0e-06	0.00390	1.3e-05	6.0e-06	3.6e-07
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0870	0.0390	0.00022	0.030	0.054	0.023	NA	0.034	7.5e-03	0.00047	1.8e-02	NA	4.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Major Depression (MDD)	3.8	4.7	8.6	0.9	2.1	2.6	2.9	2.4	1.3
Tinnitus: Yes, but not now, but have in the past	3.7	3.9	10.8	3.3	2.2	-0.8	2.5	-0.8	0.3
Emphysema/chronic bronchitis	3.7	4.1	5.6	2.2	1.6	1.9	2.3	2.4	1.7
Allergy or Eczema	3.0	7.8	16.3	-2.5	-1.4	-4.0	-2.0	-3.3	-2.7
Medication: Atorvastatin	2.9	3.6	7.2	-2.0	-2.7	-1.8	1.2	-2.2	-0.8
Diabetes (father)	2.7	3.4	7.2	1.2	-1.7	1.9	0.1	2.7	2.3
Hayfever, allergic rhinitis or eczema	2.7	5.8	9.9	-2.3	-1.1	-3.2	-2.7	-2.3	-2.4
Neck or shoulder pain in last month	2.6	3.7	7.4	0.6	0.3	2.5	1.1	2.6	2.7
Pain all over the body in last month	2.5	2.7	4.5	1.8	1.9	-1.4	0.4	-1.7	-2.1
Ever taken oral contraceptive pill	2.5	2.8	7.8	0.0	0.1	2.2	-0.3	2.0	2.8
Financial difficulties in last 2 years	2.3	3.1	7.8	1.5	-0.9	1.8	0.9	2.8	1.8
Exposure to tobacco smoke outside home	2.2	3.0	5.6	1.4	1.6	-1.9	1.9	-2.4	-0.6
Hand grip strength (right)	2.1	5.8	11.1	-2.4	-1.8	-3.3	-0.1	-2.9	-2.6
Birth weight of first child	2.1	3.8	8.6	-1.4	-1.7	-2.9	0.8	-2.3	-1.8
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	6.8	-2.6	-2.1	-1.8	-1.7	-1.0	-1.3
Supplements: Vitamin C	1.9	2.3	5.0	0.3	1.1	-1.7	-1.2	-2.2	-1.7
Blood White Count	1.8	13.6	31.1	0.9	-1.7	5.6	-0.2	5.2	4.4
Average weekly fortified wine intake	1.8	2.2	3.2	1.3	1.6	1.8	-1.2	1.2	1.6
Glaucoma (self-reported)	1.8	2.1	5.1	-0.2	0.5	-2.2	-0.7	-2.3	-1.5
Ever depressed for a whole week	1.8	2.2	4.5	-1.0	1.2	2.1	0.4	2.1	1.4
Smoking Status	1.7	4.0	8.5	-0.3	-1.5	2.9	-0.1	2.8	2.3
Hand grip strength (left)	1.7	4.4	9.2	-3.0	-1.7	-2.4	0.1	-2.7	-1.2
Allergy	1.7	3.8	7.9	1.5	0.1	2.8	1.8	2.0	2.3
Medication: Lansoprazole	1.7	1.9	4.4	1.2	2.1	-0.6	1.5	-1.7	-0.0
Shortness of breath walking on level ground	1.7	2.1	5.5	2.0	1.6	-0.2	2.3	-0.3	0.6
Relative age voice broke	1.6	2.4	5.0	-0.7	-0.5	-2.0	-1.8	-2.2	-1.3
Multivitamins +/- minerals	1.6	2.0	3.8	-2.0	-0.6	-1.7	0.7	-1.9	-0.8
Diverticular disease/diverticulitis (self-reported)	1.6	1.8	4.5	0.6	0.2	2.1	1.0	1.8	1.3
Age at first live birth	1.6	2.8	5.2	-2.2	-1.7	-1.2	-2.3	-1.5	-0.6
Alcohol intake frequency.	1.6	3.8	6.5	1.9	1.2	-2.0	2.5	-1.8	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	4.2	1.4	0.2	-1.2	2.0	-1.6	-0.9
Illnesses of father: Heart disease	1.6	2.2	6.4	-1.5	1.1	-2.5	1.0	-1.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	5.8	0.4	-0.1	-1.7	-0.1	-2.4	-1.1
Back pain experienced in last month	1.6	2.3	4.3	-1.4	-0.8	1.2	2.0	1.2	2.1
Mother’s age at death	1.6	1.9	5.3	0.5	2.3	-1.8	0.8	-1.2	-0.9
Medication: Bendroflumethiazide	1.6	2.4	5.5	0.3	1.6	-2.2	0.9	-2.4	-0.6
Sensitivity / hurt feelings	1.5	2.6	6.7	0.7	-0.2	2.2	0.6	1.7	2.6
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.9	0.2	0.8	1.9	2.4	1.5	0.6
Relative age of first facial hair	1.5	3.0	5.2	-1.7	-0.9	-1.8	-2.3	-1.9	-1.5
Medication for hormone replacement therapy	1.5	1.7	2.8	-0.7	-1.6	1.0	1.4	1.7	1.2
Qualifications: CSEs or equivalent	1.5	2.0	4.9	2.0	0.3	-0.2	2.2	-0.2	1.7
Smoking status: Previous	1.5	2.3	5.4	-0.1	-0.8	2.0	-2.3	1.2	1.4
Financial situation satisfaction	1.5	1.9	6.5	-0.5	-0.1	0.8	2.5	1.5	1.3
Reaction Time	1.4	2.7	8.0	0.5	-0.2	-2.7	-0.6	-2.8	-0.8
Prostate Cancer	1.4	2.0	3.4	-1.2	-1.7	1.0	-1.7	0.3	1.8
Ever had hysterectomy (womb removed)	1.4	1.6	2.8	0.8	-0.8	1.7	1.6	1.3	1.1
Prospective memory result	1.4	1.8	7.8	2.8	-0.0	0.3	0.6	0.3	1.5
Mean time to correctly identify matches	1.4	2.7	8.5	0.3	0.5	-2.5	-0.1	-2.9	-1.1
Ever had bowel cancer screening	1.4	1.7	5.9	-0.6	-0.4	-1.1	-0.2	-1.5	-2.4
Qualifications: nursing, teaching	1.4	2.2	5.2	-2.3	-1.8	-1.2	-0.9	-1.4	-0.6
Average weekly champagne plus white wine intake	1.4	1.9	6.4	-0.4	0.7	-1.4	-2.5	-1.6	-0.3
Eye problems/disorders: Glaucoma	1.4	1.6	4.9	-0.3	0.2	-1.8	-0.3	-2.2	-1.2
Unable to work because of sickness or disability	1.4	1.8	6.6	0.6	2.6	-0.4	1.8	0.0	-0.9
Bipolar Disorder (2018)	1.3	2.1	5.9	0.8	0.5	-1.3	2.4	-2.0	0.2
Vitamin and mineral supplements	1.3	1.8	4.4	0.9	-0.6	1.9	-0.3	2.1	1.2
Supplements: Zinc	1.3	1.4	3.1	-1.2	-1.8	-1.2	-0.6	-1.5	0.4
Severe depression (siblings)	1.3	1.5	4.6	0.9	2.1	-1.2	1.3	-0.6	-0.4
Medication: Levothyroxine sodium	1.3	2.1	5.2	0.1	0.4	-2.3	0.3	-1.7	-2.1
High blood pressure (siblings)	1.3	1.9	5.3	2.1	2.3	0.2	0.3	0.6	1.0
Comparative body size at age 10	1.3	3.7	10.4	0.7	-0.4	-2.1	-1.5	-2.1	-3.2
Friendships satisfaction	1.3	1.6	4.1	-0.6	0.4	1.7	-0.4	2.0	1.5
Cholesterol lowering medication	1.3	1.9	5.2	-1.0	1.4	-0.3	2.3	-1.2	-1.4
Depression (Nagel 2018)	1.2	1.7	4.0	0.9	0.7	2.0	1.6	0.9	1.2
Blood Red Count	1.2	11.6	23.8	1.1	-1.7	2.9	-4.5	3.7	4.9
Taking other prescription medications	1.2	1.8	3.2	0.6	1.4	-1.6	0.9	-1.8	-1.3
Forced vital capacity (FVC)	1.2	4.5	10.1	-2.5	-1.6	-2.5	0.2	-1.4	-3.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.6	0.7	-0.4	1.6	1.9	1.5	1.8
Falls in the last year	1.2	1.7	3.5	-1.2	-0.5	1.9	0.7	1.6	1.4
Medication: Lisinopril	1.2	1.6	4.2	0.3	1.7	-2.0	0.6	-1.4	-0.2
Alcohol drinker status: Never	1.2	1.5	6.1	1.4	0.6	0.5	0.0	0.4	2.5
Fasting Glucose	1.1	1.3	2.6	-1.2	1.1	-0.8	1.4	-0.3	1.6
Chronotype (morning person)	1.1	2.5	5.5	-2.3	-1.0	-1.7	-0.4	-1.4	-1.9
Systolic blood pressure, automated reading	1.1	3.1	10.1	1.2	3.2	-1.9	0.1	-1.8	-0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.6	1.4	-0.7	-0.9	1.9	-0.4	-0.9
Stomach or abdominal pain in last month	1.1	1.3	4.0	1.0	2.0	-0.3	1.0	-1.1	0.7
Qualifications: None of the above	1.1	2.3	10.0	1.8	0.2	0.1	3.2	0.1	0.5
Happiness	1.1	1.3	2.8	-0.4	0.7	1.4	-0.5	1.6	1.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.4	-0.2	-0.2	-2.2	0.8	-1.4	-2.3
Commuting to job workplace: Walk	1.1	1.2	4.0	0.7	2.0	0.8	-1.2	0.2	0.6
Osteoarthritis (self-reported)	1.1	1.4	4.0	0.5	1.2	0.8	2.0	0.8	1.3
Guilty feelings	1.1	1.7	4.8	2.2	1.3	1.4	0.5	1.1	0.6
Commuting to job workplace: Public transport	1.1	1.4	5.8	-2.4	0.1	0.7	-1.0	0.9	0.3
Risk taking	1.1	1.7	3.6	-0.4	-1.9	1.8	1.1	1.2	0.7
Heart disease (siblings)	1.1	1.3	5.9	0.0	0.5	0.8	2.4	0.4	0.9
Alzheimer’s Disease (including proxy)	1.0	1.5	5.4	-1.1	0.3	-1.1	0.3	-1.0	-2.3
Systolic Blood Pressure	1.0	4.8	11.4	-0.2	2.3	-3.4	-0.8	-3.0	-1.4
Cardiovascular Disease	1.0	3.2	8.2	0.9	0.8	-2.9	0.1	-2.8	-1.4
Diabetes (mother)	1.0	1.3	4.1	1.3	0.1	1.0	0.4	1.0	2.0
Chronic bronchitis/emphysema (father)	1.0	1.2	2.5	1.6	0.6	-1.1	0.8	-1.5	-0.2
Past tobacco smoking	1.0	1.9	4.2	0.2	1.1	-2.0	1.4	-1.4	-1.3
Medication: Simvastatin	1.0	1.5	5.0	0.0	2.2	-1.1	-0.7	-1.2	-0.8
Mouth/teeth dental problems: Dentures	1.0	1.7	3.7	0.9	-0.6	1.8	1.9	1.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	0.3	0.4	-1.5	-1.5	-1.4	-0.6
Eye problems/disorders: None of the above	1.0	1.2	2.6	0.9	-1.5	1.1	0.2	1.6	-0.6
Suffer from ‘nerves’	1.0	1.6	4.5	2.1	1.2	1.2	-0.4	0.8	1.3
Had major operations	1.0	1.2	3.2	0.7	0.8	0.8	-1.8	1.5	-0.4
Knee pain experienced in last month	1.0	1.6	3.1	-0.8	0.2	1.6	1.0	1.8	1.5
Loneliness, isolation	1.0	1.4	4.2	0.5	0.3	2.1	-0.8	1.4	1.0
Medication: Gliclazide	1.0	1.1	2.7	0.4	0.0	-1.2	0.6	-1.4	-1.6
Diastolic blood pressure, automated reading	1.0	3.1	9.2	1.4	3.0	-2.4	0.1	-1.4	-0.3
Rheumatoid Arthritis	0.9	1.2	3.5	1.9	-1.5	-0.4	0.8	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.5	0.4	1.2	-1.2	-1.0	-0.9	-1.0
Blood Eosinophil Count	0.9	7.1	17.8	-2.6	-1.7	4.2	-0.7	3.4	1.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.1	-1.4	1.2	-0.6	1.0	-0.8	-1.1
Father’s age at death	0.9	1.2	2.3	-0.5	-0.2	1.3	-1.5	1.3	-1.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	5.9	-1.8	-1.0	-2.4	0.6	-1.6	-2.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.6	-2.6	-0.9	-0.6	-2.0	-0.4	-0.2
Lung cancer (father)	0.9	1.1	1.6	1.3	1.1	-1.2	1.0	-1.0	-0.5
Blood clot in the leg (DVT)	0.9	1.1	2.5	-0.6	-0.2	-1.0	1.6	-0.9	-1.5
Forced vital capacity (FVC), Best measure	0.9	3.4	7.3	-1.7	-1.1	-2.4	0.7	-1.8	-2.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.8	-0.9	0.3	0.9	0.3	1.3	1.7
Handedness (chirality/laterality): Left-handed	0.9	1.0	3.8	0.1	0.0	1.2	1.0	0.0	1.9
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.9	1.1	1.7	-0.8	-1.0	-0.7	-0.6
Number of operations (self-reported)	0.9	1.3	3.2	0.8	0.7	1.7	-0.4	1.8	0.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.3	-0.7	-0.0	-1.3	0.1	-1.2	-1.5
Body Mass Index (BMI) (2010)	0.8	1.2	2.4	1.0	0.7	-1.5	1.0	-1.4	-0.2
Number of treatments/medications taken	0.8	1.4	2.9	-0.1	0.4	-1.7	1.2	-1.6	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.4	0.6	0.7	1.5	1.1	1.1	0.8
Supplements: Glucosamine	0.8	1.0	2.0	-1.2	0.4	1.4	-0.2	1.1	1.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.0	-1.1	-1.3	-1.4	-0.6	-0.8	-0.7
Illnesses of mother	0.8	1.0	5.2	-2.3	-0.6	0.6	0.4	0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	5.7	-1.4	-0.4	-2.4	0.6	-2.0	-1.7
Exposure to tobacco smoke at home	0.8	0.9	2.6	0.2	0.6	0.7	1.3	1.6	0.5
Hair/balding pattern: Pattern 4	0.8	2.0	4.3	0.3	0.1	-2.1	1.6	-2.0	-0.8
Worry too long after embarrassment	0.8	1.3	3.2	0.2	-0.4	1.3	-1.6	1.8	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.5	0.3	-0.8	1.0	1.9	0.8	-0.4
Health satisfaction	0.8	1.0	2.9	-0.6	1.7	-0.8	1.2	-0.7	-0.4
Medication: Allopurinol	0.8	1.1	2.0	0.3	1.3	-0.9	-0.9	-1.4	1.1
Leg pain on walking	0.8	1.1	3.0	1.1	1.7	0.5	0.9	1.0	0.4
Average weekly red wine intake	0.8	1.2	2.9	-1.0	-1.7	-0.4	-1.6	-0.5	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.7	-0.5	1.6	-1.1	0.7	-0.9	-0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.4	-0.5	1.8	0.5	1.1	0.6	0.6
High cholesterol (Self-reported)	0.8	1.4	2.6	-0.8	-0.8	-1.3	0.9	-1.5	-1.6
Illnesses of father: High blood pressure	0.8	1.0	1.8	0.9	-0.6	1.2	-1.3	1.2	0.0
Ever smoked	0.8	1.3	2.2	-1.3	-1.5	1.5	-1.2	0.6	0.2
Average weekly beer plus cider intake	0.8	1.2	4.5	1.0	0.9	-0.8	2.1	-0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	6.2	-1.2	-0.8	2.0	0.5	2.5	0.1
Age at First Birth	0.7	1.0	4.0	-2.0	-1.3	-0.3	-0.1	-0.6	-0.0
Coronary Artery Disease (CAD)	0.7	0.8	3.8	-0.7	0.6	0.3	-1.9	0.5	-0.2
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	-0.3	-1.4	0.8	0.6	1.5	-0.5
Had menopause	0.7	0.8	2.2	0.5	0.9	-0.7	1.5	-1.1	-0.4
Heart attack	0.7	0.9	2.1	1.0	1.1	-0.7	-0.6	-1.4	0.7
Medication: Ramipril	0.7	0.9	3.7	-0.2	-1.2	-0.3	0.0	-1.9	-0.4
Alcohol intake versus 10 years previously	0.7	1.0	2.5	1.2	-0.1	-0.8	1.6	-1.3	0.4
Pulse rate	0.7	1.3	3.0	-0.4	1.1	-1.6	0.8	-1.7	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.6	-1.6	-1.1	0.2	0.9	0.5	-0.2
Pulse wave Arterial Stiffness index	0.7	0.8	3.8	0.9	0.2	0.2	1.9	0.2	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.9	1.0	0.8	1.2	0.6	1.4	0.8
Pulse wave peak to peak time	0.7	0.8	3.3	-0.9	-0.2	-0.5	-1.8	-0.3	-0.7
Age at last live birth	0.7	1.0	2.7	-0.7	-1.0	-1.3	-0.5	-1.7	0.4
Illnesses of siblings: Diabetes	0.7	0.8	2.5	0.9	0.5	-1.0	-0.2	-1.6	-0.4
Eye problems/disorders: Cataract	0.7	0.8	2.8	-1.4	0.3	-0.0	-0.1	-0.3	1.7
Osteoporosis (self-reported)	0.7	0.9	3.6	0.9	-0.5	0.5	1.9	-0.3	-0.6
Myopia	0.7	1.0	3.1	-0.1	-1.2	-1.0	-0.5	-0.8	-1.8
Pain experienced in last month	0.7	1.2	3.7	0.1	-0.4	-1.1	-0.8	-1.2	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	2.1	0.0	0.1	-1.0	1.4	-0.9	-1.3
Alcohol drinker status: Previous	0.7	0.8	2.5	-0.4	-0.0	-0.6	1.6	-1.1	-0.9
Crohns Disease (2012)	0.6	1.0	2.4	0.3	-0.2	1.1	-1.6	1.2	0.8
HDL Cholesterol	0.6	1.1	2.2	-0.2	-1.4	1.5	-0.1	1.4	0.6
Triglycerides	0.6	1.0	5.3	0.6	2.3	0.4	0.2	0.4	0.2
Hypothyroidism (self reported)	0.6	1.3	3.5	-0.2	-0.7	-1.6	0.5	-1.1	-1.9
Lung FEV1/FVC ratio	0.6	3.2	8.8	-0.0	1.5	-1.9	3.0	-1.9	0.8
Neuroticism	0.6	1.4	3.3	1.8	1.2	1.4	0.7	0.9	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.8	0.2	1.4	-0.7	0.1	-0.6	-1.0
Angina	0.6	0.8	2.4	1.5	0.2	0.4	0.4	-0.5	1.4
Townsend deprivation index at recruitment	0.6	0.8	2.9	0.6	0.2	0.5	1.1	1.7	-0.3
Current tobacco smoking	0.6	0.9	2.6	-0.3	-0.4	0.7	1.6	1.3	0.8
Alcohol usually taken with meals	0.6	1.0	2.9	-0.3	0.0	-0.8	-1.7	-0.5	-1.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.9	-0.6	0.3	0.6	1.7	0.5	0.7
Loud music exposure frequency	0.6	0.7	2.1	1.4	0.9	-0.1	0.8	0.6	-0.4
Birth weight	0.6	1.4	6.9	-1.0	-2.6	-0.4	0.3	0.2	-0.4
Medication: Ibuprofen	0.6	0.7	2.4	-1.6	-1.2	0.1	0.6	0.2	-0.2
Overall health rating	0.6	1.4	4.5	0.7	0.9	0.9	2.1	0.1	1.2
Mood swings	0.6	1.1	4.0	2.0	1.1	0.6	0.6	0.7	0.2
Miserableness	0.6	1.1	2.1	1.3	0.3	1.4	1.1	1.2	-0.3
Wears glasses or contact lenses	0.6	0.7	1.2	-0.7	0.1	-1.0	-0.7	-0.9	-1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	0.9	0.8	-0.7	-0.7	-1.5	0.5
Bipolar Disorder or Schizophrenia	0.5	1.3	3.6	0.7	-0.3	-1.8	0.6	-1.9	-0.2
Depressed Affect (Nagel 2018)	0.5	1.0	4.3	2.1	0.6	0.9	0.7	0.4	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.6	-1.0	-0.1	-0.4	-1.2	0.5	-1.3
Alzheimer’s Disease (in mother)	0.5	0.6	2.6	-0.0	-0.4	-0.8	0.0	-0.4	-1.6
Alzheimer’s Disease (in father)	0.5	0.5	1.7	-1.1	0.3	-0.3	-0.2	-0.2	-1.3
Crohns Disease (2017)	0.5	1.1	2.8	0.7	-0.5	1.7	0.2	1.6	0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.7	-0.7	-0.3	-1.2	1.3	-0.5	-1.9
Ulcerative Colitis	0.5	0.7	2.2	1.2	0.1	0.0	1.5	-0.4	-0.6
High blood pressure	0.5	1.5	4.9	0.6	0.4	-1.9	-0.3	-2.2	-0.3
Number of incorrect matches in round	0.5	0.9	2.0	-0.4	1.4	-0.3	-0.9	-1.4	-0.6
Neuroticism score	0.5	1.1	2.9	1.7	0.6	1.2	0.1	1.1	0.6
Noisy workplace	0.5	0.6	2.1	0.1	0.9	0.0	0.8	0.2	1.4
Medication: Cholesterol lowering	0.5	0.7	2.6	-1.6	-0.8	-0.5	-0.7	-0.5	-0.4
Pulse wave reflection index	0.5	0.7	1.9	-0.5	-0.2	0.5	1.1	0.7	-1.4
Gout (self-reported)	0.5	0.6	1.5	0.8	1.2	-1.0	-0.1	-0.8	-0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.1	-0.5	-0.7	0.8	0.0	1.4	0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	0.5	1.0	0.0	1.1	0.5	1.0
Number of children fathered	0.5	0.5	1.6	0.4	0.1	-0.5	-1.2	-0.9	0.6
Angina (self-reported)	0.5	0.6	1.6	1.2	0.2	0.2	0.4	-0.8	1.3
Migraine (self-reported)	0.5	0.6	2.0	-0.1	-1.4	-0.2	-1.0	0.5	0.3
Heart disease (mother)	0.5	0.6	1.6	0.9	1.3	-0.3	-0.5	-0.9	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	0.3	1.3	-0.8	0.2	-0.6	0.8
Hypertension (Self-reported)	0.5	1.3	4.1	0.5	0.2	-1.8	-0.2	-2.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.0	0.4	-0.8	-1.7	0.8	-0.8	-0.9
Breast cancer (self-reported)	0.5	0.6	1.4	0.2	-0.5	-1.1	0.5	-0.7	-1.2
Illnesses of father: None of the above (group 1)	0.5	0.7	1.6	-1.2	-0.5	1.2	-0.8	0.2	0.4
Smoking status: Current	0.5	0.9	2.5	-0.6	-0.7	0.5	1.6	0.9	0.8
Number of self-reported non-cancer illnesses	0.5	0.8	1.9	0.3	-0.0	-1.3	0.2	-1.4	-1.1
Medication: Paracetamol	0.5	0.8	2.8	1.7	0.8	-0.1	1.0	0.1	0.4
Age started oral contraceptive pill	0.5	0.7	1.6	-0.3	0.8	1.3	-0.4	1.2	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.6	-0.3	-1.0	0.0	-0.7	-0.3	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.6	-1.9	-0.3	-0.7	0.3	-0.0	-1.7
Neuroticism (Nagel 2018)	0.4	0.9	2.5	1.6	0.8	1.2	0.4	0.7	0.4
Schizophrenia (2018)	0.4	0.7	1.6	0.3	-0.7	-1.3	-1.2	-0.8	-0.3
Ulcerative Colitis (UC)	0.4	0.7	2.5	0.3	0.1	-0.1	1.6	-0.6	-1.1
Bipolar Disorder (2011)	0.4	0.4	1.2	0.7	-0.9	0.2	1.1	-0.1	0.0
LDL Cholesterol	0.4	0.6	1.5	-0.4	-0.5	-0.7	0.5	-0.9	-1.2
Primary Biliary Cirrhosis	0.4	0.6	2.6	1.6	0.5	-0.2	0.6	0.4	-0.4
Schizophrenia (2014)	0.4	0.9	3.5	0.2	-0.2	-1.9	0.1	-1.1	-0.8
Blood Platelet Count	0.4	4.9	9.5	-3.1	1.1	2.9	1.5	2.6	1.1
Lung FVC	0.4	2.2	8.5	-0.8	-0.3	-1.6	0.0	-1.2	-2.9
Average weekly spirits intake	0.4	0.5	1.2	0.8	1.1	0.4	-0.6	0.6	0.7
Hearing difficulty/problems: Yes	0.4	0.6	2.0	0.3	0.4	-0.9	0.1	-0.7	-1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	-0.3	0.1	1.3	0.4	1.1	-0.0
Medication: Co-codamol	0.4	0.5	1.9	-0.1	0.6	0.3	1.4	0.5	0.5
Pack years adult smoking proportion	0.4	0.6	2.2	-1.5	-0.2	-0.1	0.9	-0.0	-0.7
High blood pressure (mother)	0.4	0.6	2.2	1.5	-0.3	-0.4	-0.5	-0.2	1.0
Impedance of leg (left)	0.4	1.9	8.2	-0.7	0.5	0.6	-2.9	0.5	1.4
Nervous feelings	0.4	0.8	2.5	1.6	1.1	0.2	-0.8	-0.3	-0.4
Illnesses of siblings	0.4	0.6	1.4	-1.2	-0.6	0.1	-1.0	0.4	-0.8
Worrier / anxious feelings	0.4	0.8	1.9	0.8	0.1	-0.9	-0.9	-0.9	-1.4
Number of live births	0.4	0.5	1.0	1.0	0.2	0.5	-0.9	0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	0.5	0.6	-0.1	-0.6	0.2	1.3
Depression (self-reported)	0.4	0.5	1.7	1.3	0.3	-0.3	1.1	-0.2	-0.3
Length of working week for main job	0.4	0.4	0.9	-0.8	-0.8	0.5	0.2	0.9	0.2
Medication: Paracetamol	0.4	0.7	2.1	1.0	0.8	-0.5	1.5	-0.2	-0.1
Headache pain in last month	0.4	0.6	1.8	1.3	0.4	-0.1	-0.1	0.3	1.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	0.3	-0.2	1.0	0.4	1.3	0.8
Medication: Amlodipine	0.4	0.6	2.0	1.4	0.6	-0.3	-0.3	-0.9	-0.5
Number of full brothers	0.4	0.6	1.5	1.2	0.2	0.2	1.0	0.5	0.7
Medication: Blood pressure	0.4	0.6	1.7	1.0	0.5	-0.8	-0.4	-1.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.8	-0.5	0.6	0.3	1.3	0.8	0.1
Number of full sisters	0.4	0.5	1.9	0.2	-0.5	0.3	1.4	0.9	-0.0
Long-standing illness, disability or infirmity	0.4	0.6	3.4	0.1	-0.0	-0.0	1.8	-0.0	-0.6
Medication: Aspirin	0.4	0.5	0.8	0.1	-0.9	0.7	0.5	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.5	-1.6	0.4	-1.3	0.3	-1.0	-0.2
Hearing aid user	0.4	0.4	1.6	-0.1	0.2	-0.7	-1.3	0.1	-0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.2	-0.7	-0.6	-0.6	-1.1	-0.4
Fractured/broken bones in last 5 years	0.4	0.5	2.7	-0.5	1.6	-0.3	-0.3	-0.4	-0.1
Supplements: Calcium	0.4	0.5	1.0	0.2	0.2	-1.0	0.6	-0.8	-0.9
Basal cell carcinoma (self-reported)	0.4	0.5	1.8	0.3	0.0	0.5	-0.8	1.4	-0.3
Impedance of whole body	0.4	1.8	6.8	-1.8	-0.3	0.1	-2.6	0.7	0.1
Worry (Nagel 2018)	0.3	0.7	3.1	1.8	1.0	0.5	-0.1	0.1	0.3
Height	0.3	6.6	12.7	-2.5	-1.0	-3.6	1.6	-3.3	-2.5
Respiratory disease	0.3	0.8	2.3	1.1	1.5	-0.4	0.7	0.4	-0.7
Hair Pigment	0.3	7.5	24.3	0.3	0.2	4.1	0.9	4.9	1.8
Impedance of leg (right)	0.3	1.6	5.0	-0.3	0.9	0.4	-2.2	0.7	1.8
Fed-up feelings	0.3	0.5	1.9	1.4	0.5	-0.0	0.8	0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.6	-0.1	-1.6	0.2	-0.8	0.9	-0.4
Medication: Atenolol	0.3	0.4	1.9	-0.3	0.3	0.3	-1.4	-0.0	0.5
Leg predicted mass (left)	0.3	1.4	4.1	-0.1	-0.9	-1.4	2.0	-1.0	-0.6
Had other major operations	0.3	0.3	1.0	0.3	-0.5	-0.4	-0.4	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.1	0.0	-1.8	0.0	-0.1	0.8	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-0.5	0.8	0.2	-0.3	0.3	0.9
Mouth/teeth dental problems	0.3	0.4	1.8	0.7	0.0	-0.4	-1.3	-0.1	-0.4
Diabetes (self-reported)	0.3	0.5	1.4	0.6	1.2	0.0	0.5	0.0	0.9
Fluid intelligence score	0.3	0.6	2.7	-0.4	-0.3	-0.8	0.2	0.0	-1.6
Impedance of arm (right)	0.3	1.3	5.2	-2.3	-0.6	-0.1	-1.4	0.2	-0.6
Impedance of arm (left)	0.3	1.5	4.1	-2.0	-0.4	-0.5	-1.7	0.5	-1.3
Breastfed as a baby	0.3	0.3	0.6	-0.7	0.7	-0.0	0.8	-0.7	0.1
Tense / ‘highly strung’	0.3	0.6	1.2	-0.1	-1.1	0.6	-0.1	1.1	0.8
Leg fat percentage (right)	0.3	1.0	2.6	1.5	1.0	-0.0	0.3	0.1	1.6
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	0.4	-1.2	1.1	-0.3	0.4	0.6
Qualifications: College or University degree	0.3	1.1	4.1	-0.9	-0.3	0.6	-2.0	1.0	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	-0.5	-0.8	-0.0	-1.2	-0.3	-0.5
Medication: Omeprazole	0.3	0.4	1.1	-0.7	0.3	0.6	1.1	0.3	0.4
Medication: Seretide 50 evohaler	0.3	0.4	1.4	0.3	0.6	0.1	0.6	-0.3	1.2
Comparative height size at age 10	0.3	1.4	4.5	0.4	-0.1	-2.1	0.3	-1.9	-0.6
Chest pain or discomfort	0.3	0.5	1.5	0.3	0.9	0.6	0.4	0.3	1.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	-0.2	-0.9	0.2	-1.2	-0.3	-0.2
Leg fat-free mass (right)	0.3	1.4	2.8	-0.3	-1.1	-1.4	1.7	-1.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	0.2	0.9	0.3	0.4	0.1	1.3
Medication for cholesterol	0.3	0.5	2.1	-0.0	0.2	0.8	-1.4	0.4	0.0
Mineral and other dietary supplements	0.3	0.4	0.8	0.3	-0.1	0.7	0.5	0.9	0.9
Leg predicted mass (right)	0.3	1.5	3.0	-0.3	-1.1	-1.5	1.7	-1.4	-0.9
Medication: Blood pressure	0.3	0.6	1.0	0.4	1.0	-0.9	0.9	-0.8	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.4	-0.4	0.1	0.3	1.2	0.3	0.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	0.4	-0.7	0.8	0.8	0.4	-0.3
Ovarian Cancer	0.2	0.3	0.9	0.0	-0.9	0.0	-0.8	-0.6	-0.2
Mean Putamen Volume	0.2	0.2	0.5	-0.1	-0.7	0.5	0.3	-0.1	-0.7
HbA1C	0.2	0.2	0.7	-0.4	-0.2	-0.3	-0.4	-0.8	0.4
Neuroticism (2016)	0.2	0.2	0.7	-0.1	0.0	0.7	0.5	-0.2	-0.8
Heel T-Score	0.2	1.2	2.6	0.3	-0.1	1.6	0.3	1.6	1.4
BMI	0.2	1.0	2.8	1.7	-0.1	-1.1	0.1	-1.4	0.6
Waist Hip Ratio (WHR)	0.2	1.0	2.2	-0.7	0.4	-1.2	1.0	-1.5	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	-0.9	0.5	-0.6	1.0	-0.4	-0.2
Leg fat-free mass (left)	0.2	1.3	3.8	-0.1	-0.9	-1.4	1.9	-1.0	-0.5
Maternal smoking around birth	0.2	0.3	0.7	0.2	-0.8	0.8	0.5	0.4	-0.1
Age when periods started (menarche)	0.2	0.4	1.2	-0.2	0.1	0.8	0.1	1.1	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	1.1	0.4	0.2	-0.7	0.1	-1.1	-0.1
Sitting height	0.2	1.6	3.9	-1.2	0.2	-2.0	-1.4	-1.4	0.5
Body mass index (BMI)	0.2	1.0	3.0	1.7	0.3	-0.4	1.4	-0.5	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.6	0.4	-0.3	-0.9	-0.0	-0.5
Weight	0.2	0.8	1.7	0.7	-0.3	-1.3	1.3	-0.9	0.2
Trunk fat-free mass	0.2	1.3	4.0	-0.1	-0.3	-1.3	2.0	-1.4	0.1
Time employed in main current job	0.2	0.3	0.8	0.5	-0.7	0.1	-0.2	0.1	-0.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.4	-0.6	0.9	-0.3	-0.6	-0.5
Asthma	0.2	0.3	1.2	0.2	0.3	-0.4	-0.6	-0.1	-1.1
Arm fat mass (right)	0.2	0.7	1.9	1.2	0.1	-0.6	1.4	-0.4	0.7
Trunk predicted mass	0.2	1.3	4.1	-0.2	-0.3	-1.3	2.0	-1.4	0.1
Standing height	0.2	2.3	4.4	-2.0	-1.4	-2.1	-0.3	-1.6	-0.9
Peak expiratory flow (PEF)	0.2	0.5	1.3	-0.4	-1.1	-0.9	-0.3	-0.3	-0.8
Leg fat mass (right)	0.2	0.8	1.5	1.2	0.4	-0.5	1.1	-0.4	1.2
Arm predicted mass (right)	0.2	0.8	1.7	0.1	-0.8	-1.3	1.1	-1.2	-0.2
Pulse rate, automated reading	0.2	0.7	1.7	0.9	0.5	-0.1	1.3	-0.4	1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.7	0.9	-0.7	0.1	0.2	0.4	0.4
Medication: Aspirin	0.2	0.3	0.7	0.7	-0.8	0.2	0.7	0.3	0.3
Whole body fat-free mass	0.2	1.3	4.2	-0.2	-0.7	-1.3	2.0	-1.3	-0.2
Asthma (self-reported)	0.2	0.3	1.2	-0.0	0.2	-0.3	-0.7	0.0	-1.1
Whole body water mass	0.2	1.4	4.2	-0.2	-0.7	-1.4	2.0	-1.3	-0.4
Arm fat mass (left)	0.2	0.7	2.0	1.1	0.2	-0.9	1.4	-0.5	0.2
Basal metabolic rate	0.2	1.2	3.7	0.2	-0.6	-1.4	1.9	-1.2	-0.0
Leg fat percentage (left)	0.2	0.7	1.9	1.3	0.8	0.1	-0.0	-0.1	1.4
Arm fat-free mass (left)	0.2	0.9	3.0	0.4	-0.6	-1.0	1.7	-1.1	0.3
Pack years of smoking	0.2	0.3	1.0	-1.0	-0.0	0.1	0.9	-0.1	-0.5
Arm predicted mass (left)	0.2	1.0	3.0	0.7	-0.3	-1.1	1.7	-1.1	0.3
Lupus	0.1	0.1	0.3	0.5	0.4	-0.0	-0.3	-0.0	0.1
Tanning	0.1	0.9	3.4	0.4	1.9	-0.6	-0.5	-1.1	0.5
Medication: Metformin	0.1	0.2	0.7	0.8	0.4	-0.1	0.5	0.1	-0.5
Trunk fat mass	0.1	0.2	0.5	0.6	-0.0	-0.7	0.4	-0.4	0.6
Waist circumference	0.1	0.5	1.0	1.0	-0.1	-0.2	1.0	-0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.7	0.5	-0.0	0.5	0.2	-0.0
Arm fat percentage (right)	0.1	0.5	1.3	1.1	0.4	-0.2	1.0	0.1	0.7
Hip circumference	0.1	0.5	1.1	1.0	-0.3	0.6	0.6	0.7	0.9
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.3	-0.3	-0.2	-0.1	-0.0	0.6
Body fat percentage	0.1	0.3	1.1	1.0	0.4	-0.3	-0.3	0.1	0.8
Arm fat-free mass (right)	0.1	0.8	2.0	0.4	-0.5	-1.2	1.4	-0.9	-0.1
Whole body fat mass	0.1	0.4	0.9	1.0	0.3	-0.6	0.5	-0.4	0.8
Arm fat percentage (left)	0.1	0.3	0.9	0.9	0.3	-0.5	0.8	0.1	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.9	0.2	0.6	-0.2	1.0	-0.1	-0.1
Irritability	0.1	0.2	0.5	-0.1	0.2	-0.6	0.3	0.1	-0.7
Leg fat mass (left)	0.1	0.5	1.4	1.0	0.3	-0.3	0.7	-0.4	1.2
Breast Cancer	0.0	0.1	0.1	-0.3	0.2	-0.2	-0.2	0.4	-0.3
Trunk fat percentage	0.0	0.2	0.5	0.7	-0.0	-0.5	-0.4	-0.1	0.6
Family relationship satisfaction	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.1	-0.2	-0.3

Hub : Genes

UBE2H

Models

Trait associations