Hub : Genes

UBE2Q2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2690 0.0420 0.0e+00 0.228 0.215 0.224 0.226 0.232 2.5e-27 1.0e-25 7.9e-27 4.5e-27 8.7e-28
2 GTEx Adrenal Gland 0.2203 0.0833 2.5e-03 0.109 NA 0.082 NA 0.090 1.0e-04 NA 6.8e-04 NA 3.9e-04
3 GTEx Cells Transformed fibroblasts 0.1890 0.0750 5.1e-04 0.088 NA 0.103 NA 0.066 3.8e-07 NA 4.2e-08 NA 1.1e-05
4 GTEx Nerve Tibial 0.1164 0.0414 6.4e-04 0.053 NA 0.083 NA 0.084 1.2e-04 NA 1.7e-06 NA 1.6e-06
5 GTEx Prostate 0.3930 0.1380 9.8e-03 0.036 NA -0.010 NA -0.012 4.5e-02 NA 6.7e-01 NA 9.9e-01
6 METSIM Adipose 0.1385 0.0433 2.3e-07 0.042 0.070 0.086 0.088 0.076 5.4e-07 1.2e-10 7.2e-13 3.7e-13 1.6e-11
7 YFS Blood 0.1371 0.0348 4.9e-12 0.024 0.050 0.071 0.066 0.073 1.6e-08 6.4e-16 2.7e-22 1.3e-20 9.0e-23
8 TCGA Breast Invasive Carcinoma 0.0304 0.0161 1.8e-03 0.001 0.007 0.021 NA 0.002 1.4e-01 1.1e-02 3.4e-05 NA 1.4e-01
9 TCGA Pancreatic Adenocarcinoma 0.1450 0.0760 6.5e-03 0.006 0.016 0.016 NA 0.000 1.8e-01 6.6e-02 6.5e-02 NA 3.0e-01
10 TCGA Uterine Corpus Endometrial Carcinoma 0.2490 0.0960 1.5e-03 0.042 0.075 0.114 NA 0.128 2.5e-02 3.9e-03 4.5e-04 NA 2.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.2 0.3 0.9 -0.6 -0.2 -0.2 -0.4 -0.5 0.5 0.3 -0.9 -0.7 0.0
Bipolar Disorder or Schizophrenia 0.4 1.0 6.3 -0.2 1.1 -1.0 -0.9 -2.5 -0.0 -0.6 -0.4 -0.0 0.0
Depressed Affect (Nagel 2018) 0.3 0.5 1.6 -0.0 -0.8 0.7 0.5 1.3 0.5 0.8 0.9 -0.3 -0.7
Depression (Nagel 2018) 0.3 0.5 1.8 0.4 0.3 0.7 1.1 1.3 0.6 0.4 0.0 -1.0 -0.2
Intelligence (Savage-Jansen 2018) 0.3 0.8 3.1 0.1 1.7 0.8 -0.2 -0.5 0.4 -0.1 0.9 0.5 -1.8
Neuroticism (Nagel 2018) 0.4 1.0 2.5 -0.0 0.7 1.3 0.7 0.7 1.4 1.3 1.6 0.8 0.1
Schizophrenia (2018) 0.8 1.6 7.3 0.2 1.7 -0.9 -0.7 -2.7 -0.3 -1.0 1.4 1.3 0.0
Schizophrenia vs Biploar Disorder 0.2 0.3 1.9 0.1 -1.4 -0.4 0.0 -0.5 -0.6 -0.2 0.0 -0.6 0.0
Worry (Nagel 2018) 0.3 0.6 1.7 -0.2 1.0 0.9 0.0 0.4 0.7 0.2 1.3 1.1 0.3
Alzheimer’s Disease (in mother) 1.3 1.5 4.1 0.1 -1.9 0.9 0.1 -1.3 1.0 2.0 0.8 1.6 0.6
Alzheimer’s Disease (in father) 0.2 0.3 1.0 0.1 -0.4 0.6 0.2 1.0 0.5 0.8 0.4 -0.3 0.3
Alzheimer’s Disease (including proxy) 0.6 0.9 3.7 0.1 -1.4 0.4 0.0 -1.2 0.8 1.9 0.5 0.5 0.7
Crohns Disease (2017) 0.1 0.2 0.6 -0.4 0.4 -0.4 -0.6 -0.8 -0.5 -0.2 0.1 0.6 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 1.9 -0.9 0.8 -0.2 -1.3 -1.4 -0.7 -0.7 -0.0 0.9 0.4
Ulcerative Colitis (UC) 0.6 1.1 2.9 -1.1 0.6 0.0 -1.4 -1.7 -0.8 -1.2 0.2 1.2 1.1
Major Depression (MDD) 1.5 1.8 4.8 1.3 0.2 1.7 1.0 1.0 1.9 0.0 2.2 1.7 -0.2
Reaction Time 0.9 1.6 4.3 -1.8 -0.5 0.7 -1.4 0.0 1.0 1.5 2.1 1.5 -0.5
Verbal and Numeric Reasoning (VNR) 0.7 1.7 5.2 -0.4 1.4 1.5 0.4 0.7 1.7 0.4 2.3 1.9 -0.7
Breast Cancer 0.3 0.7 2.5 1.6 -1.0 -0.6 1.3 -0.9 -0.2 0.3 -0.7 -0.3 0.1
Ovarian Cancer 0.6 0.7 2.7 0.1 -1.1 1.2 0.6 1.0 0.4 0.3 -0.5 0.5 1.6
Prostate Cancer 0.5 0.7 3.2 -0.2 1.8 -0.2 -0.1 -1.7 0.3 0.1 0.5 -0.2 -0.7
Age at First Birth 1.6 2.3 7.6 -0.1 -2.0 -2.0 -1.3 -0.8 -2.8 -1.6 -0.7 0.1 1.4
Bipolar Disorder (2011) 0.3 0.2 0.9 1.0 -0.4 -0.5 0.9 -0.4 -0.3 -0.2 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.9 3.9 1.2 -2.0 -0.5 1.0 -0.8 0.2 0.9 0.2 0.5 -0.6
Coronary Artery Disease (CAD) 0.4 0.4 1.6 1.3 0.3 -0.2 1.1 -0.1 -0.3 -0.2 -0.9 -0.7 0.0
Crohns Disease (2012) 0.3 0.4 1.7 1.2 0.5 0.9 1.3 -0.3 0.2 0.3 0.1 0.2 0.0
Mean Putamen Volume 0.6 0.7 2.6 0.4 -0.3 -0.8 -0.2 -0.3 -1.0 -0.6 -1.0 -1.6 0.8
Fasting Glucose 1.3 1.5 2.4 -0.9 1.2 1.4 0.1 1.5 1.4 1.4 1.3 1.5 0.8
HbA1C 1.7 1.9 4.8 0.4 1.6 1.3 0.7 1.1 1.9 1.5 1.4 0.8 2.2
HDL Cholesterol 0.6 1.1 3.0 -1.1 0.6 0.7 -0.5 0.2 1.2 0.7 1.4 1.7 1.2
LDL Cholesterol 0.3 0.4 1.4 0.2 -0.0 1.2 0.5 0.6 0.4 0.4 0.6 1.1 0.4
Lupus 0.4 0.5 3.7 0.0 0.4 0.6 0.1 -0.2 0.3 0.4 -0.9 0.3 1.9
Neuroticism (2016) 0.9 1.3 7.1 -1.1 0.6 0.3 -1.2 -0.4 0.6 0.3 1.0 0.8 2.7
Primary Biliary Cirrhosis 0.3 0.4 1.2 -0.4 -0.9 -0.6 -0.2 1.1 -0.7 -0.8 0.2 0.2 -0.8
Rheumatoid Arthritis 0.7 0.9 2.0 0.5 0.1 -1.3 -1.3 -1.4 -0.9 -0.5 0.4 -0.6 -1.4
Schizophrenia (2014) 0.8 1.7 5.5 -1.1 1.2 -0.0 -1.0 -2.4 0.8 0.0 1.3 2.2 0.0
Triglycerides 0.9 1.4 5.6 1.8 -1.1 0.6 2.4 0.2 0.1 0.5 -1.6 -0.6 0.7
Type 2 Diabetes (T2D) (2012) 1.9 2.2 9.2 -0.8 -1.2 1.5 0.5 1.8 1.2 1.1 1.1 1.0 3.0
Ulcerative Colitis 0.2 0.3 0.8 -0.7 -0.1 0.9 -0.7 -0.2 0.3 0.6 0.2 0.5 0.0
Blood Eosinophil Count 0.6 4.5 12.3 2.8 0.0 3.2 3.5 1.0 2.6 2.5 -0.7 0.0 0.3
Blood Platelet Count 0.7 8.5 36.9 -4.6 1.5 -0.1 -6.1 -0.6 -0.9 -2.3 3.6 1.4 -1.5
Blood Red Count 8.1 78.3 198.8 -13.9 8.7 7.6 -9.8 4.1 6.4 2.4 14.1 9.7 2.1
Blood White Count 1.1 8.3 21.7 -1.7 0.5 4.7 0.4 2.4 4.3 3.1 2.8 2.8 2.8
Heel T-Score 0.7 5.4 13.2 3.0 3.3 1.8 3.6 2.0 2.4 1.8 1.4 -1.3 -1.2
BMI 1.7 10.0 24.7 -0.4 -0.1 4.1 -0.2 1.9 4.3 4.6 5.0 3.9 -0.1
Height 1.4 27.5 57.3 6.3 -2.0 -7.6 2.0 -5.8 -6.1 -3.7 -6.6 -4.3 -4.8
Waist Hip Ratio (WHR) 1.3 5.7 12.1 -2.2 1.5 2.5 -2.4 -0.4 2.4 2.9 3.5 2.0 -2.8
Systolic Blood Pressure 0.8 3.9 8.2 2.9 1.1 -2.0 1.8 -1.6 -2.0 -2.5 -2.6 -1.5 -0.7
Smoking Status 0.3 0.8 2.7 0.8 -0.2 0.2 0.9 -0.7 -0.9 -1.1 -1.6 -0.4 1.2
Allergy or Eczema 2.1 5.6 13.4 -0.1 -0.3 -3.3 -2.2 -3.6 -3.7 -3.4 -1.2 -0.3 -0.1
Cardiovascular Disease 0.7 2.4 6.6 1.1 0.7 2.6 1.4 0.4 1.9 1.6 1.9 1.7 0.5
Hypothyroidism (self reported) 0.6 1.4 4.6 0.6 0.0 1.4 0.8 2.1 1.1 1.2 0.6 -0.7 -1.5
Respiratory disease 0.5 1.1 2.9 1.3 -0.5 -1.1 -0.4 -1.7 -1.4 -1.1 -0.8 -0.7 0.0
Type 2 Diabetes (T2D) (2018) 2.7 5.0 19.6 -2.6 2.7 1.4 -2.2 0.5 1.9 0.6 4.4 2.1 -0.7
Lung FEV1/FVC ratio 2.5 12.8 28.9 -3.1 -0.4 4.2 -0.7 3.2 5.4 5.0 3.3 4.1 2.8
Lung FVC 0.3 1.5 4.4 1.7 -0.4 -0.8 2.1 -0.5 -0.3 -0.9 -2.0 -1.2 -0.3
Neuroticism 0.2 0.5 1.7 0.5 -1.3 0.1 0.8 0.3 0.2 0.7 0.1 0.3 1.2
Chronotype (morning person) 0.5 1.1 2.8 -1.0 -0.2 -1.2 -0.8 -1.5 -0.8 -1.5 -0.5 0.2 1.7
Hair Pigment 0.1 1.7 4.2 0.1 0.7 -1.4 -0.3 -1.6 -1.6 -2.0 -1.9 -0.9 0.7
Tanning 0.0 0.3 1.3 -0.1 0.1 -0.1 -0.1 -0.5 -1.1 -0.7 -0.2 -0.2 -0.6
Hand grip strength (left) 0.1 0.3 1.3 0.4 -0.2 -0.6 -0.2 -0.5 -0.8 -0.4 -1.2 -0.3 0.2
Number of treatments/medications taken 1.0 1.7 12.4 -0.4 -3.5 -0.5 -0.5 -0.7 -1.1 0.6 -0.9 -0.1 1.1
Average weekly spirits intake 3.4 4.2 8.9 -0.3 -0.4 -2.7 -2.2 -3.0 -2.9 -2.2 -0.4 -1.5 -2.3
Sensitivity / hurt feelings 0.2 0.4 2.2 0.1 -0.6 0.3 0.7 0.3 0.5 0.3 -0.1 -0.2 1.5
Frequency of depressed mood in last 2 weeks 0.2 0.2 1.1 0.4 0.8 -0.1 0.4 0.0 -0.0 -0.2 -0.2 -1.0 0.3
Hearing difficulty/problems: Yes 0.3 0.5 1.6 -0.6 0.7 0.4 -0.6 -0.0 0.5 0.9 1.3 0.1 -0.9
Relative age of first facial hair 0.3 0.7 1.1 -1.0 -1.0 -0.6 -0.9 -0.9 -0.5 -0.1 -0.6 -0.9 -1.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.3 -1.0 -0.9 0.2 -0.9 1.0 -0.0 -0.5 0.5 1.2 1.5
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.5 1.3 -0.4 -0.3 1.9 0.1 -0.6 -1.3 -1.0 -1.0 0.2
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 0.0 0.8 0.3 0.2 0.7 0.8 0.2 0.9 0.2 -0.3
Systolic blood pressure, automated reading 1.1 3.1 9.9 1.1 0.7 -2.5 -0.2 -1.4 -2.8 -3.1 -1.5 -0.9 -0.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.3 0.1 -0.6 -1.3 -0.3 -0.6 -1.5 -0.9 -0.9 -1.5 -0.5
Angina 1.4 1.8 4.9 -1.0 -0.2 0.6 -0.7 -0.9 1.2 1.7 2.1 2.2 1.4
Medication for hormone replacement therapy 1.6 1.8 6.4 1.8 -1.7 0.5 2.5 -0.4 0.6 0.1 -1.3 0.7 1.3
Vitamin and mineral supplements 1.3 1.7 6.7 0.8 0.2 1.9 0.8 0.5 1.4 0.7 0.7 1.5 2.6
Supplements: Zinc 0.8 0.9 4.3 0.7 2.1 0.3 0.6 1.3 0.7 0.0 0.1 -0.4 -1.2
Medication: Co-codamol 0.4 0.4 1.5 -0.4 -1.2 0.0 -0.2 0.2 0.8 1.2 0.1 0.7 0.2
Medication: Metformin 1.6 2.3 9.8 -1.1 2.5 1.0 -0.7 -0.0 1.8 0.3 3.1 0.8 -0.4
Diabetes (father) 2.3 2.9 7.2 -2.7 1.8 1.4 -1.9 0.6 1.1 0.1 2.6 1.5 1.4
Diabetes (mother) 0.3 0.4 1.0 -0.2 1.0 0.9 0.0 0.6 0.6 0.6 0.7 0.3 -0.6
Severe depression (siblings) 0.7 0.8 1.5 0.9 -1.2 -1.2 0.8 -0.5 -0.8 -0.6 -0.7 -1.0 -0.7
Pack years adult smoking proportion 1.0 1.5 5.8 0.8 -0.2 0.8 1.5 2.4 1.1 1.5 0.9 -0.3 -1.1
Impedance of leg (right) 0.4 2.0 7.5 0.3 1.6 -1.7 0.4 -0.8 -2.2 -2.7 -0.7 -0.9 -0.5
Leg fat-free mass (left) 0.4 1.9 6.3 1.8 -1.4 0.4 0.3 -0.5 1.2 2.5 0.9 0.7 -2.0
Trunk fat percentage 0.5 1.8 7.4 -0.0 -0.0 1.1 -0.5 0.4 0.9 0.6 2.7 2.6 1.1
Hand grip strength (right) 0.0 0.1 0.4 -0.2 -0.7 -0.3 -0.1 -0.1 -0.4 -0.0 -0.4 0.3 0.0
Townsend deprivation index at recruitment 0.7 1.0 3.7 1.9 0.5 0.5 1.4 0.6 0.5 0.1 -0.2 0.7 1.7
Current tobacco smoking 1.3 2.1 6.1 1.5 0.4 2.2 2.5 0.9 1.8 1.4 -1.2 -0.0 0.5
Average weekly fortified wine intake 3.3 3.8 13.2 -0.0 -1.0 -2.5 -1.2 -1.6 -3.6 -3.1 -1.7 -1.0 -0.6
Maternal smoking around birth 1.5 2.2 3.6 1.3 0.6 1.8 1.8 1.3 1.9 1.1 0.3 1.7 1.9
Fed-up feelings 0.5 1.0 2.7 -0.3 -0.1 1.3 0.1 1.3 1.0 1.6 1.6 0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 0.9 0.7 0.3 0.6 1.0 0.6 0.6 0.8 0.1 0.2 -0.4
Relative age voice broke 0.3 0.5 2.2 0.1 -0.2 -0.4 0.3 -0.1 -0.7 -1.5 -0.4 -0.6 -1.0
Taking other prescription medications 0.4 0.6 3.0 0.2 -1.7 -0.1 0.3 -0.3 0.6 1.0 -0.2 0.4 0.9
Age when periods started (menarche) 0.7 1.6 4.5 0.7 -0.2 -1.9 -0.4 -0.7 -2.1 -1.4 -1.4 -0.9 -1.5
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 4.1 -0.3 -2.0 -0.3 -0.3 -0.4 -0.9 -1.0 -0.1 -1.3 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 3.2 1.4 0.6 1.5 1.7 0.4 1.2 1.3 1.0 -0.6 -1.8
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 2.1 0.2 1.5 -0.2 -0.2 0.3 -0.2 -0.1 0.2 0.2 -1.0
Qualifications: CSEs or equivalent 2.1 2.8 8.5 -0.1 0.4 1.8 0.4 2.9 2.2 2.6 1.2 0.0 -1.8
Serious illness, injury or assault to yourself 2.2 2.6 7.3 1.1 -1.1 2.2 1.6 1.0 2.3 2.7 0.6 0.8 1.6
High blood pressure 0.3 0.9 5.0 2.2 0.9 0.3 1.7 -0.4 -0.0 -0.1 -0.5 -0.3 -0.3
Hayfever, allergic rhinitis or eczema 1.2 2.6 5.7 -0.9 -1.2 -2.1 -2.3 -2.4 -2.4 -1.6 -0.2 -0.4 0.1
Multivitamins +/- minerals 1.2 1.5 6.1 -1.5 -0.1 -1.2 -1.4 0.5 -0.9 -0.2 0.1 -1.4 -2.5
Stomach or abdominal pain in last month 1.4 1.7 3.7 0.7 0.9 1.4 1.4 1.0 1.9 1.3 1.6 1.5 0.9
Supplements: Glucosamine 0.9 1.2 3.1 -0.5 1.0 -1.4 -0.6 -1.7 -1.4 -1.8 -0.8 0.3 -0.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 4.4 -1.2 -0.9 0.6 -0.9 1.0 0.6 0.5 2.1 1.7 0.9
Medication: Atenolol 0.2 0.3 1.0 -0.0 -0.0 0.2 0.7 0.0 0.9 1.0 -0.6 -0.5 0.1
Medication: Levothyroxine sodium 0.7 1.1 4.8 0.5 0.3 1.1 0.9 2.2 0.5 0.7 -0.5 -1.3 -1.1
Sitting height 0.4 2.7 10.1 3.2 -1.5 -0.9 2.7 -0.9 -0.9 0.0 -2.2 -0.3 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 4.4 1.0 -0.8 -1.0 0.6 -2.1 -0.7 -0.6 -1.5 -0.8 0.1
High blood pressure (mother) 0.7 0.9 3.4 1.0 -1.0 -0.8 0.2 -1.1 -0.1 0.6 -0.9 -0.8 -1.9
Body mass index (BMI) 1.5 6.4 12.9 -0.3 -0.4 3.5 0.2 2.1 3.6 3.6 3.5 2.9 1.1
Impedance of leg (left) 0.6 2.7 11.2 -0.1 1.9 -1.9 -0.2 -1.1 -2.6 -3.3 -0.8 -0.2 0.6
Leg predicted mass (left) 0.4 2.0 6.6 1.9 -1.5 0.5 0.5 -0.3 1.3 2.6 0.9 0.7 -2.0
Trunk fat mass 0.3 1.4 5.0 0.7 -0.3 0.9 -0.1 0.2 0.9 1.1 2.2 2.2 0.3
Waist circumference 1.2 4.4 11.8 -0.5 0.2 2.6 -0.5 0.8 2.7 2.8 3.4 2.9 -0.3
Number of incorrect matches in round 1.4 2.4 7.6 -0.5 -0.3 -1.1 -0.9 1.0 -2.4 -2.8 -2.0 -1.4 1.1
Past tobacco smoking 1.3 2.3 5.1 0.8 1.0 2.0 0.7 2.2 2.3 2.1 1.5 0.4 -0.1
Alcohol usually taken with meals 0.7 1.2 3.0 0.1 -0.1 -1.5 -0.5 -1.3 -1.7 -1.6 -1.3 -0.5 -0.2
Nervous feelings 0.1 0.2 1.2 -0.8 0.1 -0.1 -1.1 -0.3 -0.3 -0.2 0.4 0.2 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 3.1 0.3 -1.8 0.2 0.8 -0.5 0.4 1.5 -0.1 -0.5 0.4
Hearing difficulty/problems with background noise 0.4 0.7 1.7 0.2 0.9 0.5 0.1 -1.3 0.6 0.8 1.3 1.2 -0.8
Hair/balding pattern: Pattern 2 1.5 1.9 6.3 1.6 -1.8 -1.1 1.5 -0.9 -0.5 -0.3 -2.5 -1.3 0.2
Had menopause 1.3 1.7 3.2 1.7 0.4 -0.5 1.7 -0.9 -0.4 -1.8 -1.5 -1.1 1.8
Had other major operations 0.8 0.9 4.9 -1.0 0.4 1.0 -0.6 -0.5 0.4 -1.0 0.1 0.7 2.2
Forced vital capacity (FVC) 1.2 4.5 9.9 1.9 -0.7 -2.8 0.1 -1.9 -2.5 -1.6 -2.6 -2.0 -3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.5 1.4 0.6 1.2 1.6 -0.1 0.9 1.1 1.2 -0.2 -0.6
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 1.2 -0.4 -0.3 -0.2 0.3 -0.7 -0.1 -0.7 -1.0 -1.0
Qualifications: None of the above 1.1 2.3 10.7 -0.5 0.2 1.9 0.8 1.4 1.0 0.3 0.9 2.1 3.3
Financial difficulties in last 2 years 0.8 1.1 1.9 1.4 1.2 1.0 1.1 0.1 1.4 1.2 0.4 1.3 0.7
Mouth/teeth dental problems 0.2 0.3 1.2 0.7 -1.1 0.4 0.7 -0.0 0.2 0.9 -0.0 -0.3 0.1
Heart attack 1.1 1.4 3.7 -0.3 0.2 1.9 0.6 0.7 1.9 1.8 1.3 0.9 -0.3
Allergy 0.5 1.3 3.1 0.3 0.8 1.5 1.8 1.2 1.7 1.2 0.2 0.5 -0.8
Pain all over the body in last month 1.0 1.1 4.1 1.2 -0.5 -1.0 1.0 -0.0 -1.2 -0.5 -2.0 -0.9 0.9
Diabetes (self-reported) 3.3 5.0 16.0 -3.1 2.7 0.6 -3.4 0.8 0.1 -0.8 4.0 1.7 -1.0
Hayfever/allergic rhinitis (self-reported) 3.2 4.3 11.2 -1.2 0.4 -3.3 -2.8 -1.4 -3.2 -2.4 -1.4 -0.7 -1.2
Medication: Ramipril 0.8 1.0 2.7 1.6 1.1 -0.2 1.1 -1.3 -0.7 -1.0 -1.1 -0.3 -0.5
Medication: Simvastatin 0.6 0.9 3.1 0.4 0.7 1.4 0.8 0.4 1.0 0.2 1.1 0.1 1.8
Fluid intelligence score 1.0 2.0 7.2 -0.5 2.0 1.4 -0.5 -0.2 0.9 -0.3 2.3 2.7 -0.2
Illnesses of siblings 0.4 0.6 2.4 0.6 1.6 0.4 0.7 -0.6 0.6 0.2 0.7 -0.5 -1.0
Neuroticism score 0.3 0.5 1.3 0.2 -0.0 0.9 0.4 1.1 0.7 1.0 1.0 0.5 0.5
Weight 0.3 1.7 5.1 1.3 -1.0 1.0 0.5 0.1 1.5 2.2 1.7 1.6 -0.7
Impedance of arm (right) 0.9 4.2 13.8 -0.6 -0.7 -3.7 -1.2 -1.7 -3.3 -2.9 -0.6 -1.6 -0.9
Arm fat percentage (right) 1.0 4.1 12.5 -0.7 -0.5 2.1 -0.5 1.4 2.4 2.5 3.5 2.8 1.2
Trunk fat-free mass 0.4 2.3 6.8 2.6 -1.1 -0.1 1.5 -0.7 0.8 2.2 -0.8 -0.5 -2.3
Hip circumference 0.3 1.1 1.9 0.8 -1.0 1.0 0.7 1.2 1.0 0.9 1.4 1.4 0.9
Time employed in main current job 0.5 0.6 3.8 -0.3 -0.4 -0.6 -0.4 -2.0 -0.4 0.7 0.5 -0.1 -0.5
Alcohol intake versus 10 years previously 2.4 3.6 8.6 1.9 -1.1 2.5 2.9 2.2 2.1 2.6 -0.3 -0.9 -0.1
Father’s age at death 2.0 2.7 4.7 0.3 1.5 -2.2 -0.6 -2.1 -1.9 -1.6 -1.9 -1.8 -1.6
Worrier / anxious feelings 1.1 2.1 7.1 -0.7 0.3 -1.1 -1.4 -2.7 -0.9 -1.1 0.6 1.6 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 3.0 -1.2 -0.4 1.0 -0.8 1.7 0.5 1.4 1.1 -0.4 -0.2
Falls in the last year 0.3 0.4 1.2 0.2 0.7 -1.1 -0.5 -0.3 -0.7 -0.5 -0.3 -0.2 1.1
Hair/balding pattern: Pattern 3 0.4 0.5 2.1 -0.1 1.5 0.6 -0.5 -0.2 0.2 -0.3 0.3 0.6 1.3
Number of live births 1.3 1.8 6.6 1.8 0.5 0.1 2.6 0.7 0.5 0.8 -1.5 -1.5 -1.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 4.2 1.5 -0.5 -1.3 0.2 -0.8 -0.8 0.0 -1.5 -0.9 -2.0
Pulse rate 0.9 1.6 4.0 -0.7 -1.4 1.0 0.0 2.0 1.9 1.7 1.0 0.8 -0.7
Happiness 1.6 1.9 5.4 0.9 -0.3 -2.3 -0.0 -0.9 -2.3 -1.2 -1.4 -1.9 0.4
Noisy workplace 1.0 1.2 2.5 0.6 -0.6 1.0 1.0 1.6 1.4 1.6 -0.1 -0.3 1.5
Qualifications: A levels/AS levels or equivalent 1.9 4.1 10.6 -0.3 0.6 -2.8 -1.6 -2.6 -2.8 -3.3 -1.2 -1.6 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.2 -0.9 0.0 0.2 -0.8 1.5 0.7 0.5 1.1 0.5 -1.0
Mouth/teeth dental problems: Dentures 1.9 3.3 9.5 -3.0 0.3 -2.0 -3.1 -1.2 -1.6 -2.2 0.4 0.8 0.8
Asthma 0.3 0.5 1.5 0.3 -0.7 -1.2 -0.8 -1.2 -0.8 -0.5 -0.1 -0.1 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.7 0.1 0.1 1.0 1.3 1.3 0.6 0.0 0.0 0.2 0.2
Medication: Cholesterol lowering 1.0 1.5 4.6 1.1 -1.6 1.0 1.8 0.7 0.7 1.2 0.2 -0.2 2.1
Depression (self-reported) 0.8 0.9 2.9 1.7 -1.3 -0.7 0.9 -1.2 0.4 0.7 -0.2 -0.6 -0.8
Medication: Lansoprazole 1.2 1.3 3.4 0.2 0.3 1.8 0.8 0.0 1.6 1.6 0.4 1.2 1.6
Prospective memory result 0.3 0.4 1.6 0.9 -0.1 0.1 1.3 0.7 -0.1 -0.3 -0.6 -0.8 -0.2
Lung cancer (father) 2.4 2.8 8.6 -0.5 0.1 2.0 -0.3 1.5 2.4 2.9 2.4 0.2 -1.3
Illnesses of mother 0.9 1.1 5.4 -1.3 -0.0 0.7 -0.1 2.3 0.4 -0.2 1.6 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 3.7 1.9 -0.4 -1.4 0.8 -1.0 -0.9 -0.2 -1.9 -0.8 -1.4
Pulse wave Arterial Stiffness index 1.3 1.5 4.2 -1.3 1.0 1.6 -0.2 1.7 1.3 0.6 2.0 0.7 -0.3
Impedance of arm (left) 1.5 6.7 18.3 -1.0 -0.6 -4.3 -1.9 -2.5 -4.2 -4.1 -1.1 -1.3 -0.4
Arm fat mass (right) 0.8 3.2 8.7 0.1 -0.7 2.0 -0.0 0.8 2.3 2.7 3.0 2.4 0.3
Trunk predicted mass 0.4 2.3 6.5 2.5 -1.1 -0.2 1.4 -0.8 0.7 2.2 -0.7 -0.6 -2.5
Standing height 1.3 13.4 28.5 4.0 -1.6 -5.3 1.0 -4.0 -4.6 -2.7 -4.1 -3.0 -3.8
Length of working week for main job 0.2 0.3 1.6 0.2 -0.1 -0.5 -0.2 -0.1 0.3 0.6 1.3 -0.2 -0.3
Exposure to tobacco smoke at home 0.3 0.3 1.4 -0.2 0.5 -0.0 -1.0 -0.5 0.1 0.3 0.3 1.2 -0.6
Breastfed as a baby 0.3 0.3 1.2 -0.8 -0.0 0.2 -0.5 1.1 -0.5 -0.1 0.2 -0.7 -0.3
Tense / ‘highly strung’ 0.9 1.4 4.4 -1.1 0.3 1.2 -0.8 1.0 1.2 1.2 2.1 1.6 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.5 0.0 -1.2 -1.2 -0.5 0.4 -0.2 0.5 -0.4 -0.5 -0.2
Hair/balding pattern: Pattern 4 0.4 1.0 2.9 -1.4 -0.2 0.6 -0.9 -0.1 1.1 1.7 0.6 1.4 0.8
Birth weight of first child 1.5 2.7 6.7 -0.4 0.8 2.3 -0.1 1.1 2.0 1.3 1.4 2.6 2.2
Peak expiratory flow (PEF) 0.4 0.9 4.3 -0.7 -0.4 0.6 -0.7 -0.1 0.9 1.4 0.7 0.4 -2.1
Pulse wave reflection index 0.7 0.9 2.9 -0.5 1.0 1.1 0.5 1.7 -0.2 -1.0 0.1 -0.3 1.5
Ever highly irritable/argumentative for 2 days 4.0 4.8 13.6 -3.2 0.5 1.7 -2.5 1.0 1.0 0.8 3.1 3.7 1.5
Loud music exposure frequency 0.5 0.5 1.6 -0.0 -1.3 0.1 0.3 1.2 0.4 1.2 -0.5 0.2 -0.5
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.6 -0.6 -0.1 -1.7 -1.6 -1.2 -2.1 -2.1 -0.6 -0.2 -1.1
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.5 0.1 1.2 0.3 0.0 0.0 0.4 -0.3 0.5 0.6 0.5
Blood clot in the leg (DVT) 0.4 0.6 1.6 1.3 1.2 -0.7 0.0 -0.6 -0.5 -0.7 -1.0 0.4 0.5
Medication: Paracetamol 0.7 1.2 3.9 -0.9 -1.7 0.9 0.0 0.8 1.0 2.0 0.1 0.6 1.2
Headache pain in last month 1.7 2.9 7.8 -0.7 -1.2 2.8 0.4 0.3 2.3 2.5 2.1 1.6 0.9
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 5.0 -1.8 1.6 -1.9 -2.2 -1.0 -0.9 -1.2 -0.2 -0.7 -2.2
Glaucoma (self-reported) 0.3 0.4 0.8 0.5 -0.9 -0.9 -0.2 -0.6 -0.7 -0.3 -0.4 -0.2 -0.8
Gout (self-reported) 6.3 8.6 33.7 4.6 -2.6 1.9 5.8 0.4 2.0 3.3 -2.0 -1.2 0.4
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 5.2 0.7 0.4 1.6 1.2 2.3 1.5 1.5 0.9 -0.5 -2.1
Medication: Amlodipine 0.6 0.8 2.5 1.6 -0.7 -0.6 0.7 -0.5 -1.1 -0.5 -0.8 0.5 1.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 -0.5 -0.2 -1.0 -0.8 -0.7 -0.8 -0.3 -0.4 -0.8 -0.2
Birth weight 0.6 1.3 3.9 -1.2 -0.6 -1.2 -2.0 -1.1 -1.2 -1.1 0.1 -0.7 -1.3
Chronic bronchitis/emphysema (mother) 0.4 0.4 2.6 0.1 0.3 -0.2 -0.5 -0.5 -0.3 -0.2 -1.0 0.3 1.6
High blood pressure (siblings) 0.4 0.6 3.2 -0.9 -1.8 -0.3 -1.0 0.0 -0.6 -0.1 0.2 0.6 -0.0
Forced vital capacity (FVC), Best measure 1.4 5.2 9.6 2.5 -0.6 -3.1 0.8 -2.4 -2.8 -1.9 -3.1 -1.8 -2.3
Body fat percentage 0.7 2.8 9.7 -0.3 0.2 1.7 -0.5 0.9 1.5 1.2 3.1 2.9 1.3
Leg fat percentage (right) 1.0 3.5 12.6 -0.8 0.4 2.1 -0.8 1.1 2.0 1.6 3.6 2.9 0.9
Arm fat-free mass (right) 0.3 1.6 6.4 2.5 -0.5 0.7 1.4 -0.3 1.1 1.9 -0.1 0.8 -1.2
Exposure to tobacco smoke outside home 0.5 0.7 3.6 0.3 0.4 1.0 -0.4 0.0 0.4 0.1 0.8 1.9 1.1
Comparative body size at age 10 0.3 0.8 3.1 -1.0 -0.2 -0.7 -1.8 -0.3 0.4 0.8 1.2 0.3 -1.1
Number of full brothers 1.5 1.9 3.8 0.2 0.6 1.8 1.2 1.6 1.6 1.3 1.0 1.9 1.6
Worry too long after embarrassment 0.3 0.4 1.8 0.7 1.1 0.5 0.6 -0.1 0.6 -0.1 0.2 0.4 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.3 5.6 1.8 -2.4 -1.2 1.7 1.4 -1.2 0.1 -1.4 -2.0 -0.5
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.9 -0.8 -0.3 0.7 -0.6 -0.6 0.0 -0.7 -0.6 -0.4
Number of children fathered 1.2 1.3 3.7 -0.6 -1.0 -1.2 -0.4 -0.2 -1.2 -0.5 -1.6 -1.4 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 6.4 -0.2 0.9 -1.2 -0.9 -2.4 -1.5 -2.5 -0.9 -0.0 0.5
Age at first live birth 0.7 1.3 3.2 -1.0 -1.6 -0.6 -1.6 -1.8 -0.7 -0.2 1.1 0.2 -1.3
Pulse wave peak to peak time 1.7 1.9 5.0 1.6 -0.9 -1.8 0.4 -2.0 -1.5 -0.7 -2.2 -1.0 0.0
Health satisfaction 1.1 1.5 3.0 1.3 -1.2 1.2 1.6 1.7 0.9 1.7 0.7 0.5 0.3
Shortness of breath walking on level ground 1.9 2.2 6.6 -1.0 0.9 2.0 -0.4 2.6 1.2 0.5 2.0 1.9 0.3
Qualifications: College or University degree 0.4 1.3 2.9 1.4 -0.6 -1.5 0.6 -1.7 -1.3 -1.3 -0.7 -1.0 -0.4
Eye problems/disorders: None of the above 1.0 1.2 3.8 -1.7 2.0 0.3 -1.6 -0.5 0.6 -0.3 0.8 -0.4 -1.0
Mouth/teeth dental problems: Loose teeth 1.3 1.5 5.0 -0.1 0.1 -1.3 -1.1 -0.3 -1.8 -2.2 -1.4 -0.1 1.4
Emphysema/chronic bronchitis 0.4 0.5 2.0 -0.1 -1.4 -0.4 -0.5 0.5 -0.2 0.0 0.4 -1.1 -0.9
Medication for pain relief, constipation, heartburn 1.5 2.5 5.8 0.2 1.0 -2.0 -1.0 -1.8 -2.1 -2.4 -1.4 -1.6 -1.1
Neck or shoulder pain in last month 0.6 0.9 2.9 -0.1 0.7 1.7 0.3 -1.4 1.4 0.9 0.6 0.6 0.4
Medication: Blood pressure 0.6 1.0 4.1 2.0 -0.1 1.1 1.4 -1.1 0.4 0.4 0.1 0.5 0.8
Angina (self-reported) 1.5 2.0 5.2 -1.0 -0.2 1.0 -0.5 -0.6 1.5 1.9 2.1 2.3 1.2
Migraine (self-reported) 1.0 1.3 4.1 -1.8 -0.1 0.4 -1.7 0.0 0.6 1.2 2.0 0.1 -0.8
Medication: Ibuprofen 0.2 0.3 0.9 -0.1 -0.2 0.6 0.6 1.0 0.0 0.0 -0.1 -0.6 -0.6
Medication: Allopurinol 6.2 8.2 34.4 4.3 -1.4 2.3 5.9 1.3 2.2 3.0 -2.0 -1.6 0.8
Medication: Omeprazole 0.6 0.8 3.6 -0.1 -1.9 0.5 0.2 1.1 0.7 0.6 -0.7 -0.1 1.1
Medication: Seretide 50 evohaler 0.4 0.5 1.5 0.7 0.2 -0.6 0.5 -1.1 -0.7 -0.6 -1.2 -0.6 -0.0
Mean time to correctly identify matches 0.5 1.0 3.0 -1.7 -0.3 -0.3 -1.7 -0.9 0.2 0.4 1.4 0.8 -0.7
Heart disease (mother) 0.7 0.9 3.1 1.8 1.3 0.0 1.2 -0.9 -0.0 -0.5 -0.8 -0.7 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 1.2 0.3 -0.0 -0.6 0.0 -1.1 0.2 -0.4 -0.2 -0.3 0.1
Whole body fat mass 0.5 2.3 7.3 0.5 -0.3 1.4 -0.2 0.4 1.5 1.8 2.7 2.7 0.5
Leg fat mass (right) 0.9 3.6 10.3 0.3 -0.1 2.1 -0.0 1.0 2.2 2.3 3.2 3.1 0.4
Arm predicted mass (right) 0.3 1.4 5.9 2.4 -0.2 0.5 1.3 -0.5 1.0 1.7 -0.2 0.7 -1.4
Pulse rate, automated reading 1.2 3.7 7.7 0.4 0.4 2.5 1.0 2.5 2.8 2.5 2.2 0.9 -2.0
Alcohol intake frequency. 3.8 8.8 23.4 2.9 1.3 4.8 4.0 2.7 3.7 3.9 1.2 1.0 0.3
Comparative height size at age 10 1.9 10.6 26.1 2.0 -2.2 -5.1 -0.6 -3.3 -4.9 -3.4 -4.2 -2.4 -0.8
Number of full sisters 2.9 3.5 10.1 -0.1 1.4 1.9 0.8 1.2 3.2 2.6 2.3 2.2 0.4
Suffer from ‘nerves’ 1.2 1.9 4.3 0.2 1.6 2.1 0.8 0.4 2.0 1.1 1.9 1.6 0.2
Overall health rating 1.5 3.3 8.1 -1.4 -0.6 1.7 -0.6 1.1 2.3 2.8 2.8 2.1 0.5
Chest pain or discomfort 1.1 1.6 3.9 -0.3 0.8 2.0 0.7 1.2 1.9 1.6 1.7 0.5 0.3
Had major operations 0.4 0.5 1.4 -1.2 -0.6 0.6 -0.6 0.3 0.5 1.1 0.5 0.4 0.4
Age at last live birth 0.3 0.5 1.3 -0.8 -0.7 -0.3 -1.1 -1.0 0.1 0.4 0.5 -0.1 -1.1
Family relationship satisfaction 0.4 0.5 1.2 0.3 -1.0 -0.1 0.1 0.7 -0.3 1.0 0.3 -1.1 -1.0
Leg pain on walking 1.0 1.2 2.8 0.9 1.3 1.3 1.1 1.7 1.2 0.8 0.8 1.1 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 2.0 0.5 -1.4 -0.8 0.3 -0.8 -0.6 -0.3 -0.9 -0.1 -0.8
Commuting to job workplace: Car/motor vehicle 1.1 1.3 5.0 0.9 -0.3 1.1 1.6 0.3 1.1 0.6 -0.9 1.0 2.2
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 4.9 -0.5 -1.0 -2.0 -0.6 -1.4 -2.2 -1.8 -1.2 -1.8 -0.7
Medication: Aspirin 0.2 0.2 0.5 0.7 0.6 0.6 0.5 -0.3 -0.1 -0.2 0.6 -0.0 0.6
Supplements: Vitamin C 0.4 0.4 1.8 0.4 0.7 -0.4 0.8 0.5 -0.3 -0.6 0.1 -0.5 -1.4
Knee pain experienced in last month 0.3 0.5 1.7 -0.3 0.5 -0.7 -1.1 -0.9 -0.1 0.3 1.3 0.2 -0.6
Hypertension (Self-reported) 0.4 1.0 5.4 2.3 1.0 0.3 1.9 -0.5 0.2 0.0 -0.4 -0.1 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 10.7 0.3 0.8 1.6 1.3 3.3 1.3 0.2 0.3 -0.0 1.1
Illnesses of father: Heart disease 1.2 1.7 3.3 -0.3 -1.7 -1.2 -0.6 1.2 -1.8 -1.8 -1.3 -1.6 -0.5
Illnesses of siblings: Diabetes 0.5 0.6 2.9 -0.1 0.5 0.7 0.7 0.6 0.6 0.0 0.4 1.1 1.7
Smoking status: Previous 2.9 4.3 10.1 -0.6 -1.1 -3.0 -1.1 -2.7 -3.2 -3.0 -1.9 -1.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.7 1.6 -0.6 -0.8 0.6 -0.3 -1.2 -0.6 -1.3 -0.3 -1.9
Whole body fat-free mass 0.3 1.9 5.5 2.3 -1.2 0.2 1.0 -0.6 1.0 2.4 -0.1 0.1 -2.0
Leg fat-free mass (right) 0.2 1.3 4.5 1.6 -1.4 0.2 0.0 -0.6 0.9 2.1 0.6 0.9 -1.5
Arm fat percentage (left) 0.9 3.7 11.3 -0.8 -0.5 1.9 -0.7 1.0 2.0 2.0 3.4 3.0 1.5
Average weekly red wine intake 1.2 1.8 4.3 -0.7 -0.1 -2.0 -1.7 -0.4 -2.1 -2.0 -1.4 -0.8 0.0
Handedness (chirality/laterality): Left-handed 1.5 1.8 6.5 -0.6 1.3 -1.4 -1.9 -2.5 -1.3 -1.0 0.2 -0.5 -1.1
Mood swings 1.0 1.7 4.3 -1.6 -1.1 1.4 -0.5 1.0 1.2 2.1 1.8 0.9 0.6
Loneliness, isolation 0.9 1.2 3.5 1.9 -1.6 0.5 1.6 0.1 0.5 1.2 0.4 -0.4 -1.2
Long-standing illness, disability or infirmity 1.9 3.0 7.6 -0.9 -0.4 2.8 -0.1 0.2 2.3 2.5 1.9 1.6 1.8
Ever had bowel cancer screening 1.5 1.8 5.1 0.3 -0.6 -2.3 -0.3 -1.7 -1.4 -1.5 -0.6 -0.5 2.1
Diabetes diagnosed by doctor 2.4 3.9 14.0 -2.0 3.0 0.8 -2.1 1.0 1.1 -0.1 3.7 1.2 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.8 -0.6 0.5 1.2 -0.3 0.9 0.8 1.3 0.7 0.1 -1.2
Friendships satisfaction 0.3 0.4 1.4 -0.6 0.4 -0.7 -0.8 0.2 -0.5 -0.1 1.2 -0.0 -0.5
Qualifications: nursing, teaching 0.5 0.7 2.6 -0.1 0.0 -1.0 -1.0 -0.7 -0.8 -1.1 0.5 -0.2 -1.6
Commuting to job workplace: Walk 0.8 0.8 3.0 0.2 0.9 1.0 0.4 1.7 0.3 -1.0 0.5 -0.2 -1.4
Eye problems/disorders: Cataract 0.9 1.0 3.0 1.4 -1.5 -0.0 1.7 0.5 -0.4 0.0 -1.4 0.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.3 0.3 1.2 0.2 0.6 1.5 0.1 0.0 -0.5 -0.6 -0.7
Medication for cholesterol 0.4 0.5 1.4 -0.9 0.8 0.3 -1.1 -0.1 0.6 0.8 1.2 0.5 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 4.0 2.0 0.1 -1.0 0.6 -0.8 -0.7 -0.9 -0.2 -0.6 0.3
Back pain experienced in last month 0.3 0.4 2.4 0.4 -1.5 0.2 0.4 0.8 -0.4 -0.6 -0.4 0.1 0.3
Mineral and other dietary supplements 1.1 1.4 5.2 0.1 -0.3 2.3 0.3 0.8 1.5 1.7 1.5 0.9 -0.1
Breast cancer (self-reported) 0.6 0.7 1.3 0.2 0.9 1.1 0.5 0.9 0.9 0.4 1.1 1.0 0.6
Asthma (self-reported) 0.3 0.5 1.6 0.2 -0.7 -1.1 -0.8 -1.3 -1.0 -0.6 0.0 0.2 0.5
Osteoporosis (self-reported) 1.2 1.5 5.5 -0.8 0.1 -2.0 -0.9 0.4 -1.7 -2.4 -0.4 -0.7 0.5
Osteoarthritis (self-reported) 0.7 1.0 2.5 -0.0 1.6 -0.6 -1.0 -1.4 -0.5 -1.1 -0.5 0.9 1.1
Medication: Aspirin 0.1 0.2 0.5 0.6 0.3 0.4 0.1 -0.5 -0.4 -0.0 0.7 -0.5 -0.4
Medication: Gliclazide 1.0 1.2 4.7 -1.1 0.7 0.6 -0.8 0.2 1.3 1.0 2.2 1.0 -0.7
Illnesses of father: None of the above (group 1) 1.4 1.7 5.6 0.1 1.1 1.6 1.1 0.0 2.4 2.3 0.8 0.9 -0.1
Smoking status: Current 0.9 1.5 4.5 1.1 0.4 2.1 2.0 0.6 1.5 1.2 -1.0 0.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.0 0.3 0.1 -1.3 -0.5 -1.4 -1.0 -0.5 -1.2 -1.2 0.2
Whole body water mass 0.3 2.0 5.8 2.4 -1.1 0.3 1.1 -0.6 1.1 2.4 -0.1 0.1 -2.0
Leg predicted mass (right) 0.3 1.4 4.6 1.6 -1.3 0.2 0.0 -0.6 0.9 2.1 0.6 0.9 -1.5
Arm fat mass (left) 0.7 3.0 7.9 0.0 -0.6 1.9 -0.2 0.9 2.1 2.4 2.8 2.6 0.7
Number of self-reported non-cancer illnesses 0.9 1.5 5.8 0.0 -0.9 1.5 0.8 1.4 1.0 0.9 0.5 1.3 2.4
Average weekly champagne plus white wine intake 0.6 0.8 3.3 -1.0 0.6 0.1 -1.2 -0.5 0.4 0.8 1.8 0.9 -0.3
Miserableness 0.1 0.1 0.5 0.3 0.5 0.1 -0.0 0.4 0.0 -0.2 0.7 -0.1 0.2
Guilty feelings 0.4 0.6 2.2 0.7 0.2 0.1 0.6 -0.9 1.0 1.5 0.7 0.4 -1.0
Wears glasses or contact lenses 1.9 2.2 6.0 0.7 -1.8 -2.5 0.4 -1.3 -1.7 -1.4 -1.9 -1.4 -0.0
Ever taken oral contraceptive pill 1.5 1.7 3.1 -1.7 0.4 1.3 -0.5 1.6 1.2 1.8 1.2 1.7 0.8
Hearing aid user 1.0 1.1 2.9 0.5 -0.6 -1.7 -0.8 -0.6 -1.6 -1.3 -0.7 -1.0 -0.8
Mother’s age at death 1.9 2.3 7.3 -0.3 -0.9 -2.7 -1.3 -0.1 -2.7 -2.1 -1.4 -0.0 0.3
Financial situation satisfaction 0.2 0.3 0.9 0.6 -0.7 -0.3 -0.1 0.4 -0.1 0.9 -0.2 -0.9 0.3
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.0 -0.9 0.3 0.7 -0.8 -0.3 1.0 1.0 1.4 0.4 0.0
Commuting to job workplace: Public transport 1.2 1.5 4.7 -0.0 -0.9 -2.2 -1.1 -1.4 -1.9 -1.1 0.2 -0.8 -0.4
Eye problems/disorders: Glaucoma 0.6 0.7 1.8 1.4 -0.9 -1.2 0.5 -0.4 -1.0 -0.5 -0.6 -0.1 -0.9
Medication: Blood pressure 1.0 1.9 3.6 1.3 0.9 -1.4 0.5 -0.9 -1.6 -1.6 -1.6 -1.6 -1.9
Pain type(s) experienced in last month: Hip pain 1.0 1.3 6.7 0.6 -0.5 -0.9 -0.0 -2.6 -0.7 -0.1 -1.5 -0.5 1.4
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.7 -0.5 -0.6 -1.6 -0.4 -1.4 -0.5 -0.3 -0.8 -0.3 0.9
High cholesterol (Self-reported) 1.4 2.5 5.2 0.0 -0.1 2.2 1.2 1.8 2.0 1.6 1.7 0.9 2.3
Medication: Bendroflumethiazide 0.6 0.9 4.2 0.9 -0.6 -0.3 0.6 -1.1 -0.4 0.2 -1.1 -0.9 -2.1
Medication: Paracetamol 0.5 0.9 2.9 -0.8 -1.7 0.5 -0.5 0.2 0.4 1.6 0.0 0.5 1.1
Medication: Lisinopril 0.7 1.0 2.9 0.6 -0.6 0.5 0.1 0.0 0.6 1.6 1.5 -0.8 -1.7
Medication: Atorvastatin 1.2 1.5 3.1 -1.4 -0.3 1.8 -0.3 1.7 1.3 1.0 1.6 1.1 0.4
Illnesses of father: High blood pressure 0.6 0.8 2.2 1.0 -1.5 -0.1 0.3 -0.4 -1.1 0.8 -0.2 -0.9 -1.4
Alcohol drinker status: Never 1.1 1.3 4.1 -1.7 2.0 1.4 -1.0 0.4 0.5 -0.5 0.7 0.9 0.8
Ever smoked 0.5 0.9 2.0 -0.1 -0.5 -1.3 0.4 -1.4 -1.2 -1.3 -1.2 -0.3 -0.5
Basal metabolic rate 0.3 1.8 6.0 2.1 -1.1 0.4 0.9 -0.5 1.3 2.5 0.4 0.5 -1.8
Leg fat percentage (left) 1.0 3.5 11.0 -0.8 0.5 2.1 -1.0 1.1 1.8 1.4 3.3 3.1 1.5
Arm fat-free mass (left) 0.4 2.1 7.0 2.7 -0.4 1.0 1.6 0.2 1.5 2.3 0.1 0.4 -1.7
Number of operations (self-reported) 0.3 0.4 1.2 0.6 0.4 0.2 1.1 0.9 0.1 -0.5 -0.5 -0.3 0.8
Average weekly beer plus cider intake 0.8 1.2 4.4 -2.1 -1.5 -0.1 -1.2 -1.0 0.6 1.1 0.5 0.0 -0.9
Irritability 0.2 0.3 1.1 -0.5 0.9 0.3 -0.1 0.4 0.2 0.5 1.0 0.3 0.5
Risk taking 1.0 1.5 8.1 -0.5 -0.6 -1.5 -0.0 0.5 -0.9 0.5 -1.0 -2.8 -1.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.1 -0.1 -0.7 -0.6 0.3 -0.8 -0.5 -0.5 -0.4 -0.3 -1.0
Fractured/broken bones in last 5 years 2.6 3.4 11.8 2.0 -0.8 -2.2 1.3 0.9 -1.8 -1.1 -2.0 -3.4 -0.9
Age started oral contraceptive pill 1.3 1.6 6.5 -0.6 0.4 -1.5 -1.4 -0.3 -1.8 -2.5 -0.3 -1.0 0.3
Diastolic blood pressure, automated reading 0.2 0.5 3.6 0.3 -0.5 -0.1 0.0 0.3 -0.1 0.8 0.4 -0.3 -1.9
Ever depressed for a whole week 0.7 0.8 2.4 -0.1 -1.2 -0.4 -1.1 1.6 -1.2 -0.0 -0.5 -0.7 -1.0
Unable to work because of sickness or disability 1.7 2.2 4.5 1.8 1.2 1.5 1.9 1.1 2.1 2.0 0.8 -0.2 -1.1
Commuting to job workplace: Cycle 0.3 0.3 2.1 0.1 1.4 -0.5 0.2 -0.0 -0.3 -0.5 -0.7 -0.4 -0.0
Myopia 1.0 1.4 4.0 -2.0 0.4 0.8 -0.8 0.0 1.5 0.6 0.8 1.0 2.0
Vascular/heart problems diagnosed by doctor 0.2 0.6 3.1 -1.8 -0.5 -0.3 -1.4 0.6 -0.1 -0.0 0.3 -0.0 -0.1
Cholesterol lowering medication 0.4 0.6 1.5 -0.7 1.0 1.0 -0.3 1.2 0.5 -0.4 0.9 -0.3 0.5
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 3.6 -0.0 -1.2 0.7 0.3 0.9 0.6 0.2 -0.3 0.9 1.9
Pain experienced in last month 0.6 1.0 2.2 0.9 0.0 -1.2 0.0 0.6 -1.2 -1.5 -0.8 -1.3 -1.0
Supplements: Calcium 1.3 1.4 5.7 0.3 1.1 -1.8 0.1 0.7 -1.5 -2.4 -0.7 -0.7 0.8
Basal cell carcinoma (self-reported) 1.1 1.3 3.0 -1.3 1.2 -1.0 -1.1 -0.7 -1.0 -0.7 -0.5 -1.4 -1.7
Heart attack/myocardial infarction (self-reported) 1.2 1.5 4.3 -0.1 0.3 2.0 0.8 0.7 2.1 1.9 1.3 0.7 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.0 0.9 1.4 -0.4 -0.2 -0.5 -0.1 -0.4 -0.6 0.6 0.7
Heart disease (siblings) 0.7 0.9 3.3 -0.1 -1.5 -0.2 0.5 1.0 0.0 0.4 -1.0 -0.8 1.8
Alcohol drinker status: Previous 0.6 0.7 1.7 1.2 0.7 0.8 0.7 -1.3 0.5 1.0 0.4 0.3 -1.1
Pack years of smoking 0.7 1.0 4.2 0.5 -0.2 0.5 1.0 2.0 0.9 1.2 1.1 0.1 -1.1
Impedance of whole body 0.9 4.7 16.6 -0.5 0.9 -3.3 -1.0 -1.7 -3.6 -4.1 -1.1 -1.0 -0.2
Leg fat mass (left) 0.9 3.7 10.7 0.1 0.0 2.2 -0.2 0.9 2.2 2.2 3.2 3.3 0.7
Arm predicted mass (left) 0.4 2.2 6.5 2.6 -0.5 1.0 1.7 0.3 1.6 2.4 0.1 0.4 -1.6