Hub : Genes

UBE2Q2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2690	0.0420	0.0e+00	0.228	0.215	0.224	0.226	0.232	2.5e-27	1.0e-25	7.9e-27	4.5e-27	8.7e-28
2	GTEx	Adrenal Gland	0.2203	0.0833	2.5e-03	0.109	NA	0.082	NA	0.090	1.0e-04	NA	6.8e-04	NA	3.9e-04
3	GTEx	Cells Transformed fibroblasts	0.1890	0.0750	5.1e-04	0.088	NA	0.103	NA	0.066	3.8e-07	NA	4.2e-08	NA	1.1e-05
4	GTEx	Nerve Tibial	0.1164	0.0414	6.4e-04	0.053	NA	0.083	NA	0.084	1.2e-04	NA	1.7e-06	NA	1.6e-06
5	GTEx	Prostate	0.3930	0.1380	9.8e-03	0.036	NA	-0.010	NA	-0.012	4.5e-02	NA	6.7e-01	NA	9.9e-01
6	METSIM	Adipose	0.1385	0.0433	2.3e-07	0.042	0.070	0.086	0.088	0.076	5.4e-07	1.2e-10	7.2e-13	3.7e-13	1.6e-11
7	YFS	Blood	0.1371	0.0348	4.9e-12	0.024	0.050	0.071	0.066	0.073	1.6e-08	6.4e-16	2.7e-22	1.3e-20	9.0e-23
8	TCGA	Breast Invasive Carcinoma	0.0304	0.0161	1.8e-03	0.001	0.007	0.021	NA	0.002	1.4e-01	1.1e-02	3.4e-05	NA	1.4e-01
9	TCGA	Pancreatic Adenocarcinoma	0.1450	0.0760	6.5e-03	0.006	0.016	0.016	NA	0.000	1.8e-01	6.6e-02	6.5e-02	NA	3.0e-01
10	TCGA	Uterine Corpus Endometrial Carcinoma	0.2490	0.0960	1.5e-03	0.042	0.075	0.114	NA	0.128	2.5e-02	3.9e-03	4.5e-04	NA	2.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.2	0.3	0.9	-0.6	-0.2	-0.2	-0.4	-0.5	0.5	0.3	-0.9	-0.7	0.0
Bipolar Disorder or Schizophrenia	0.4	1.0	6.3	-0.2	1.1	-1.0	-0.9	-2.5	-0.0	-0.6	-0.4	-0.0	0.0
Depressed Affect (Nagel 2018)	0.3	0.5	1.6	-0.0	-0.8	0.7	0.5	1.3	0.5	0.8	0.9	-0.3	-0.7
Depression (Nagel 2018)	0.3	0.5	1.8	0.4	0.3	0.7	1.1	1.3	0.6	0.4	0.0	-1.0	-0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.1	0.1	1.7	0.8	-0.2	-0.5	0.4	-0.1	0.9	0.5	-1.8
Neuroticism (Nagel 2018)	0.4	1.0	2.5	-0.0	0.7	1.3	0.7	0.7	1.4	1.3	1.6	0.8	0.1
Schizophrenia (2018)	0.8	1.6	7.3	0.2	1.7	-0.9	-0.7	-2.7	-0.3	-1.0	1.4	1.3	0.0
Schizophrenia vs Biploar Disorder	0.2	0.3	1.9	0.1	-1.4	-0.4	0.0	-0.5	-0.6	-0.2	0.0	-0.6	0.0
Worry (Nagel 2018)	0.3	0.6	1.7	-0.2	1.0	0.9	0.0	0.4	0.7	0.2	1.3	1.1	0.3
Alzheimer’s Disease (in mother)	1.3	1.5	4.1	0.1	-1.9	0.9	0.1	-1.3	1.0	2.0	0.8	1.6	0.6
Alzheimer’s Disease (in father)	0.2	0.3	1.0	0.1	-0.4	0.6	0.2	1.0	0.5	0.8	0.4	-0.3	0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	3.7	0.1	-1.4	0.4	0.0	-1.2	0.8	1.9	0.5	0.5	0.7
Crohns Disease (2017)	0.1	0.2	0.6	-0.4	0.4	-0.4	-0.6	-0.8	-0.5	-0.2	0.1	0.6	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.9	-0.9	0.8	-0.2	-1.3	-1.4	-0.7	-0.7	-0.0	0.9	0.4
Ulcerative Colitis (UC)	0.6	1.1	2.9	-1.1	0.6	0.0	-1.4	-1.7	-0.8	-1.2	0.2	1.2	1.1
Major Depression (MDD)	1.5	1.8	4.8	1.3	0.2	1.7	1.0	1.0	1.9	0.0	2.2	1.7	-0.2
Reaction Time	0.9	1.6	4.3	-1.8	-0.5	0.7	-1.4	0.0	1.0	1.5	2.1	1.5	-0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.2	-0.4	1.4	1.5	0.4	0.7	1.7	0.4	2.3	1.9	-0.7
Breast Cancer	0.3	0.7	2.5	1.6	-1.0	-0.6	1.3	-0.9	-0.2	0.3	-0.7	-0.3	0.1
Ovarian Cancer	0.6	0.7	2.7	0.1	-1.1	1.2	0.6	1.0	0.4	0.3	-0.5	0.5	1.6
Prostate Cancer	0.5	0.7	3.2	-0.2	1.8	-0.2	-0.1	-1.7	0.3	0.1	0.5	-0.2	-0.7
Age at First Birth	1.6	2.3	7.6	-0.1	-2.0	-2.0	-1.3	-0.8	-2.8	-1.6	-0.7	0.1	1.4
Bipolar Disorder (2011)	0.3	0.2	0.9	1.0	-0.4	-0.5	0.9	-0.4	-0.3	-0.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.9	3.9	1.2	-2.0	-0.5	1.0	-0.8	0.2	0.9	0.2	0.5	-0.6
Coronary Artery Disease (CAD)	0.4	0.4	1.6	1.3	0.3	-0.2	1.1	-0.1	-0.3	-0.2	-0.9	-0.7	0.0
Crohns Disease (2012)	0.3	0.4	1.7	1.2	0.5	0.9	1.3	-0.3	0.2	0.3	0.1	0.2	0.0
Mean Putamen Volume	0.6	0.7	2.6	0.4	-0.3	-0.8	-0.2	-0.3	-1.0	-0.6	-1.0	-1.6	0.8
Fasting Glucose	1.3	1.5	2.4	-0.9	1.2	1.4	0.1	1.5	1.4	1.4	1.3	1.5	0.8
HbA1C	1.7	1.9	4.8	0.4	1.6	1.3	0.7	1.1	1.9	1.5	1.4	0.8	2.2
HDL Cholesterol	0.6	1.1	3.0	-1.1	0.6	0.7	-0.5	0.2	1.2	0.7	1.4	1.7	1.2
LDL Cholesterol	0.3	0.4	1.4	0.2	-0.0	1.2	0.5	0.6	0.4	0.4	0.6	1.1	0.4
Lupus	0.4	0.5	3.7	0.0	0.4	0.6	0.1	-0.2	0.3	0.4	-0.9	0.3	1.9
Neuroticism (2016)	0.9	1.3	7.1	-1.1	0.6	0.3	-1.2	-0.4	0.6	0.3	1.0	0.8	2.7
Primary Biliary Cirrhosis	0.3	0.4	1.2	-0.4	-0.9	-0.6	-0.2	1.1	-0.7	-0.8	0.2	0.2	-0.8
Rheumatoid Arthritis	0.7	0.9	2.0	0.5	0.1	-1.3	-1.3	-1.4	-0.9	-0.5	0.4	-0.6	-1.4
Schizophrenia (2014)	0.8	1.7	5.5	-1.1	1.2	-0.0	-1.0	-2.4	0.8	0.0	1.3	2.2	0.0
Triglycerides	0.9	1.4	5.6	1.8	-1.1	0.6	2.4	0.2	0.1	0.5	-1.6	-0.6	0.7
Type 2 Diabetes (T2D) (2012)	1.9	2.2	9.2	-0.8	-1.2	1.5	0.5	1.8	1.2	1.1	1.1	1.0	3.0
Ulcerative Colitis	0.2	0.3	0.8	-0.7	-0.1	0.9	-0.7	-0.2	0.3	0.6	0.2	0.5	0.0
Blood Eosinophil Count	0.6	4.5	12.3	2.8	0.0	3.2	3.5	1.0	2.6	2.5	-0.7	0.0	0.3
Blood Platelet Count	0.7	8.5	36.9	-4.6	1.5	-0.1	-6.1	-0.6	-0.9	-2.3	3.6	1.4	-1.5
Blood Red Count	8.1	78.3	198.8	-13.9	8.7	7.6	-9.8	4.1	6.4	2.4	14.1	9.7	2.1
Blood White Count	1.1	8.3	21.7	-1.7	0.5	4.7	0.4	2.4	4.3	3.1	2.8	2.8	2.8
Heel T-Score	0.7	5.4	13.2	3.0	3.3	1.8	3.6	2.0	2.4	1.8	1.4	-1.3	-1.2
BMI	1.7	10.0	24.7	-0.4	-0.1	4.1	-0.2	1.9	4.3	4.6	5.0	3.9	-0.1
Height	1.4	27.5	57.3	6.3	-2.0	-7.6	2.0	-5.8	-6.1	-3.7	-6.6	-4.3	-4.8
Waist Hip Ratio (WHR)	1.3	5.7	12.1	-2.2	1.5	2.5	-2.4	-0.4	2.4	2.9	3.5	2.0	-2.8
Systolic Blood Pressure	0.8	3.9	8.2	2.9	1.1	-2.0	1.8	-1.6	-2.0	-2.5	-2.6	-1.5	-0.7
Smoking Status	0.3	0.8	2.7	0.8	-0.2	0.2	0.9	-0.7	-0.9	-1.1	-1.6	-0.4	1.2
Allergy or Eczema	2.1	5.6	13.4	-0.1	-0.3	-3.3	-2.2	-3.6	-3.7	-3.4	-1.2	-0.3	-0.1
Cardiovascular Disease	0.7	2.4	6.6	1.1	0.7	2.6	1.4	0.4	1.9	1.6	1.9	1.7	0.5
Hypothyroidism (self reported)	0.6	1.4	4.6	0.6	0.0	1.4	0.8	2.1	1.1	1.2	0.6	-0.7	-1.5
Respiratory disease	0.5	1.1	2.9	1.3	-0.5	-1.1	-0.4	-1.7	-1.4	-1.1	-0.8	-0.7	0.0
Type 2 Diabetes (T2D) (2018)	2.7	5.0	19.6	-2.6	2.7	1.4	-2.2	0.5	1.9	0.6	4.4	2.1	-0.7
Lung FEV1/FVC ratio	2.5	12.8	28.9	-3.1	-0.4	4.2	-0.7	3.2	5.4	5.0	3.3	4.1	2.8
Lung FVC	0.3	1.5	4.4	1.7	-0.4	-0.8	2.1	-0.5	-0.3	-0.9	-2.0	-1.2	-0.3
Neuroticism	0.2	0.5	1.7	0.5	-1.3	0.1	0.8	0.3	0.2	0.7	0.1	0.3	1.2
Chronotype (morning person)	0.5	1.1	2.8	-1.0	-0.2	-1.2	-0.8	-1.5	-0.8	-1.5	-0.5	0.2	1.7
Hair Pigment	0.1	1.7	4.2	0.1	0.7	-1.4	-0.3	-1.6	-1.6	-2.0	-1.9	-0.9	0.7
Tanning	0.0	0.3	1.3	-0.1	0.1	-0.1	-0.1	-0.5	-1.1	-0.7	-0.2	-0.2	-0.6
Hand grip strength (left)	0.1	0.3	1.3	0.4	-0.2	-0.6	-0.2	-0.5	-0.8	-0.4	-1.2	-0.3	0.2
Number of treatments/medications taken	1.0	1.7	12.4	-0.4	-3.5	-0.5	-0.5	-0.7	-1.1	0.6	-0.9	-0.1	1.1
Average weekly spirits intake	3.4	4.2	8.9	-0.3	-0.4	-2.7	-2.2	-3.0	-2.9	-2.2	-0.4	-1.5	-2.3
Sensitivity / hurt feelings	0.2	0.4	2.2	0.1	-0.6	0.3	0.7	0.3	0.5	0.3	-0.1	-0.2	1.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	1.1	0.4	0.8	-0.1	0.4	0.0	-0.0	-0.2	-0.2	-1.0	0.3
Hearing difficulty/problems: Yes	0.3	0.5	1.6	-0.6	0.7	0.4	-0.6	-0.0	0.5	0.9	1.3	0.1	-0.9
Relative age of first facial hair	0.3	0.7	1.1	-1.0	-1.0	-0.6	-0.9	-0.9	-0.5	-0.1	-0.6	-0.9	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.3	-1.0	-0.9	0.2	-0.9	1.0	-0.0	-0.5	0.5	1.2	1.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.5	1.3	-0.4	-0.3	1.9	0.1	-0.6	-1.3	-1.0	-1.0	0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.0	0.8	0.3	0.2	0.7	0.8	0.2	0.9	0.2	-0.3
Systolic blood pressure, automated reading	1.1	3.1	9.9	1.1	0.7	-2.5	-0.2	-1.4	-2.8	-3.1	-1.5	-0.9	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.3	0.1	-0.6	-1.3	-0.3	-0.6	-1.5	-0.9	-0.9	-1.5	-0.5
Angina	1.4	1.8	4.9	-1.0	-0.2	0.6	-0.7	-0.9	1.2	1.7	2.1	2.2	1.4
Medication for hormone replacement therapy	1.6	1.8	6.4	1.8	-1.7	0.5	2.5	-0.4	0.6	0.1	-1.3	0.7	1.3
Vitamin and mineral supplements	1.3	1.7	6.7	0.8	0.2	1.9	0.8	0.5	1.4	0.7	0.7	1.5	2.6
Supplements: Zinc	0.8	0.9	4.3	0.7	2.1	0.3	0.6	1.3	0.7	0.0	0.1	-0.4	-1.2
Medication: Co-codamol	0.4	0.4	1.5	-0.4	-1.2	0.0	-0.2	0.2	0.8	1.2	0.1	0.7	0.2
Medication: Metformin	1.6	2.3	9.8	-1.1	2.5	1.0	-0.7	-0.0	1.8	0.3	3.1	0.8	-0.4
Diabetes (father)	2.3	2.9	7.2	-2.7	1.8	1.4	-1.9	0.6	1.1	0.1	2.6	1.5	1.4
Diabetes (mother)	0.3	0.4	1.0	-0.2	1.0	0.9	0.0	0.6	0.6	0.6	0.7	0.3	-0.6
Severe depression (siblings)	0.7	0.8	1.5	0.9	-1.2	-1.2	0.8	-0.5	-0.8	-0.6	-0.7	-1.0	-0.7
Pack years adult smoking proportion	1.0	1.5	5.8	0.8	-0.2	0.8	1.5	2.4	1.1	1.5	0.9	-0.3	-1.1
Impedance of leg (right)	0.4	2.0	7.5	0.3	1.6	-1.7	0.4	-0.8	-2.2	-2.7	-0.7	-0.9	-0.5
Leg fat-free mass (left)	0.4	1.9	6.3	1.8	-1.4	0.4	0.3	-0.5	1.2	2.5	0.9	0.7	-2.0
Trunk fat percentage	0.5	1.8	7.4	-0.0	-0.0	1.1	-0.5	0.4	0.9	0.6	2.7	2.6	1.1
Hand grip strength (right)	0.0	0.1	0.4	-0.2	-0.7	-0.3	-0.1	-0.1	-0.4	-0.0	-0.4	0.3	0.0
Townsend deprivation index at recruitment	0.7	1.0	3.7	1.9	0.5	0.5	1.4	0.6	0.5	0.1	-0.2	0.7	1.7
Current tobacco smoking	1.3	2.1	6.1	1.5	0.4	2.2	2.5	0.9	1.8	1.4	-1.2	-0.0	0.5
Average weekly fortified wine intake	3.3	3.8	13.2	-0.0	-1.0	-2.5	-1.2	-1.6	-3.6	-3.1	-1.7	-1.0	-0.6
Maternal smoking around birth	1.5	2.2	3.6	1.3	0.6	1.8	1.8	1.3	1.9	1.1	0.3	1.7	1.9
Fed-up feelings	0.5	1.0	2.7	-0.3	-0.1	1.3	0.1	1.3	1.0	1.6	1.6	0.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.9	0.7	0.3	0.6	1.0	0.6	0.6	0.8	0.1	0.2	-0.4
Relative age voice broke	0.3	0.5	2.2	0.1	-0.2	-0.4	0.3	-0.1	-0.7	-1.5	-0.4	-0.6	-1.0
Taking other prescription medications	0.4	0.6	3.0	0.2	-1.7	-0.1	0.3	-0.3	0.6	1.0	-0.2	0.4	0.9
Age when periods started (menarche)	0.7	1.6	4.5	0.7	-0.2	-1.9	-0.4	-0.7	-2.1	-1.4	-1.4	-0.9	-1.5
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.1	-0.3	-2.0	-0.3	-0.3	-0.4	-0.9	-1.0	-0.1	-1.3	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.2	1.4	0.6	1.5	1.7	0.4	1.2	1.3	1.0	-0.6	-1.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	2.1	0.2	1.5	-0.2	-0.2	0.3	-0.2	-0.1	0.2	0.2	-1.0
Qualifications: CSEs or equivalent	2.1	2.8	8.5	-0.1	0.4	1.8	0.4	2.9	2.2	2.6	1.2	0.0	-1.8
Serious illness, injury or assault to yourself	2.2	2.6	7.3	1.1	-1.1	2.2	1.6	1.0	2.3	2.7	0.6	0.8	1.6
High blood pressure	0.3	0.9	5.0	2.2	0.9	0.3	1.7	-0.4	-0.0	-0.1	-0.5	-0.3	-0.3
Hayfever, allergic rhinitis or eczema	1.2	2.6	5.7	-0.9	-1.2	-2.1	-2.3	-2.4	-2.4	-1.6	-0.2	-0.4	0.1
Multivitamins +/- minerals	1.2	1.5	6.1	-1.5	-0.1	-1.2	-1.4	0.5	-0.9	-0.2	0.1	-1.4	-2.5
Stomach or abdominal pain in last month	1.4	1.7	3.7	0.7	0.9	1.4	1.4	1.0	1.9	1.3	1.6	1.5	0.9
Supplements: Glucosamine	0.9	1.2	3.1	-0.5	1.0	-1.4	-0.6	-1.7	-1.4	-1.8	-0.8	0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.4	-1.2	-0.9	0.6	-0.9	1.0	0.6	0.5	2.1	1.7	0.9
Medication: Atenolol	0.2	0.3	1.0	-0.0	-0.0	0.2	0.7	0.0	0.9	1.0	-0.6	-0.5	0.1
Medication: Levothyroxine sodium	0.7	1.1	4.8	0.5	0.3	1.1	0.9	2.2	0.5	0.7	-0.5	-1.3	-1.1
Sitting height	0.4	2.7	10.1	3.2	-1.5	-0.9	2.7	-0.9	-0.9	0.0	-2.2	-0.3	-0.3
Chronic bronchitis/emphysema (father)	0.9	1.1	4.4	1.0	-0.8	-1.0	0.6	-2.1	-0.7	-0.6	-1.5	-0.8	0.1
High blood pressure (mother)	0.7	0.9	3.4	1.0	-1.0	-0.8	0.2	-1.1	-0.1	0.6	-0.9	-0.8	-1.9
Body mass index (BMI)	1.5	6.4	12.9	-0.3	-0.4	3.5	0.2	2.1	3.6	3.6	3.5	2.9	1.1
Impedance of leg (left)	0.6	2.7	11.2	-0.1	1.9	-1.9	-0.2	-1.1	-2.6	-3.3	-0.8	-0.2	0.6
Leg predicted mass (left)	0.4	2.0	6.6	1.9	-1.5	0.5	0.5	-0.3	1.3	2.6	0.9	0.7	-2.0
Trunk fat mass	0.3	1.4	5.0	0.7	-0.3	0.9	-0.1	0.2	0.9	1.1	2.2	2.2	0.3
Waist circumference	1.2	4.4	11.8	-0.5	0.2	2.6	-0.5	0.8	2.7	2.8	3.4	2.9	-0.3
Number of incorrect matches in round	1.4	2.4	7.6	-0.5	-0.3	-1.1	-0.9	1.0	-2.4	-2.8	-2.0	-1.4	1.1
Past tobacco smoking	1.3	2.3	5.1	0.8	1.0	2.0	0.7	2.2	2.3	2.1	1.5	0.4	-0.1
Alcohol usually taken with meals	0.7	1.2	3.0	0.1	-0.1	-1.5	-0.5	-1.3	-1.7	-1.6	-1.3	-0.5	-0.2
Nervous feelings	0.1	0.2	1.2	-0.8	0.1	-0.1	-1.1	-0.3	-0.3	-0.2	0.4	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	3.1	0.3	-1.8	0.2	0.8	-0.5	0.4	1.5	-0.1	-0.5	0.4
Hearing difficulty/problems with background noise	0.4	0.7	1.7	0.2	0.9	0.5	0.1	-1.3	0.6	0.8	1.3	1.2	-0.8
Hair/balding pattern: Pattern 2	1.5	1.9	6.3	1.6	-1.8	-1.1	1.5	-0.9	-0.5	-0.3	-2.5	-1.3	0.2
Had menopause	1.3	1.7	3.2	1.7	0.4	-0.5	1.7	-0.9	-0.4	-1.8	-1.5	-1.1	1.8
Had other major operations	0.8	0.9	4.9	-1.0	0.4	1.0	-0.6	-0.5	0.4	-1.0	0.1	0.7	2.2
Forced vital capacity (FVC)	1.2	4.5	9.9	1.9	-0.7	-2.8	0.1	-1.9	-2.5	-1.6	-2.6	-2.0	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.5	1.4	0.6	1.2	1.6	-0.1	0.9	1.1	1.2	-0.2	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	1.2	-0.4	-0.3	-0.2	0.3	-0.7	-0.1	-0.7	-1.0	-1.0
Qualifications: None of the above	1.1	2.3	10.7	-0.5	0.2	1.9	0.8	1.4	1.0	0.3	0.9	2.1	3.3
Financial difficulties in last 2 years	0.8	1.1	1.9	1.4	1.2	1.0	1.1	0.1	1.4	1.2	0.4	1.3	0.7
Mouth/teeth dental problems	0.2	0.3	1.2	0.7	-1.1	0.4	0.7	-0.0	0.2	0.9	-0.0	-0.3	0.1
Heart attack	1.1	1.4	3.7	-0.3	0.2	1.9	0.6	0.7	1.9	1.8	1.3	0.9	-0.3
Allergy	0.5	1.3	3.1	0.3	0.8	1.5	1.8	1.2	1.7	1.2	0.2	0.5	-0.8
Pain all over the body in last month	1.0	1.1	4.1	1.2	-0.5	-1.0	1.0	-0.0	-1.2	-0.5	-2.0	-0.9	0.9
Diabetes (self-reported)	3.3	5.0	16.0	-3.1	2.7	0.6	-3.4	0.8	0.1	-0.8	4.0	1.7	-1.0
Hayfever/allergic rhinitis (self-reported)	3.2	4.3	11.2	-1.2	0.4	-3.3	-2.8	-1.4	-3.2	-2.4	-1.4	-0.7	-1.2
Medication: Ramipril	0.8	1.0	2.7	1.6	1.1	-0.2	1.1	-1.3	-0.7	-1.0	-1.1	-0.3	-0.5
Medication: Simvastatin	0.6	0.9	3.1	0.4	0.7	1.4	0.8	0.4	1.0	0.2	1.1	0.1	1.8
Fluid intelligence score	1.0	2.0	7.2	-0.5	2.0	1.4	-0.5	-0.2	0.9	-0.3	2.3	2.7	-0.2
Illnesses of siblings	0.4	0.6	2.4	0.6	1.6	0.4	0.7	-0.6	0.6	0.2	0.7	-0.5	-1.0
Neuroticism score	0.3	0.5	1.3	0.2	-0.0	0.9	0.4	1.1	0.7	1.0	1.0	0.5	0.5
Weight	0.3	1.7	5.1	1.3	-1.0	1.0	0.5	0.1	1.5	2.2	1.7	1.6	-0.7
Impedance of arm (right)	0.9	4.2	13.8	-0.6	-0.7	-3.7	-1.2	-1.7	-3.3	-2.9	-0.6	-1.6	-0.9
Arm fat percentage (right)	1.0	4.1	12.5	-0.7	-0.5	2.1	-0.5	1.4	2.4	2.5	3.5	2.8	1.2
Trunk fat-free mass	0.4	2.3	6.8	2.6	-1.1	-0.1	1.5	-0.7	0.8	2.2	-0.8	-0.5	-2.3
Hip circumference	0.3	1.1	1.9	0.8	-1.0	1.0	0.7	1.2	1.0	0.9	1.4	1.4	0.9
Time employed in main current job	0.5	0.6	3.8	-0.3	-0.4	-0.6	-0.4	-2.0	-0.4	0.7	0.5	-0.1	-0.5
Alcohol intake versus 10 years previously	2.4	3.6	8.6	1.9	-1.1	2.5	2.9	2.2	2.1	2.6	-0.3	-0.9	-0.1
Father’s age at death	2.0	2.7	4.7	0.3	1.5	-2.2	-0.6	-2.1	-1.9	-1.6	-1.9	-1.8	-1.6
Worrier / anxious feelings	1.1	2.1	7.1	-0.7	0.3	-1.1	-1.4	-2.7	-0.9	-1.1	0.6	1.6	2.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.0	-1.2	-0.4	1.0	-0.8	1.7	0.5	1.4	1.1	-0.4	-0.2
Falls in the last year	0.3	0.4	1.2	0.2	0.7	-1.1	-0.5	-0.3	-0.7	-0.5	-0.3	-0.2	1.1
Hair/balding pattern: Pattern 3	0.4	0.5	2.1	-0.1	1.5	0.6	-0.5	-0.2	0.2	-0.3	0.3	0.6	1.3
Number of live births	1.3	1.8	6.6	1.8	0.5	0.1	2.6	0.7	0.5	0.8	-1.5	-1.5	-1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.2	1.5	-0.5	-1.3	0.2	-0.8	-0.8	0.0	-1.5	-0.9	-2.0
Pulse rate	0.9	1.6	4.0	-0.7	-1.4	1.0	0.0	2.0	1.9	1.7	1.0	0.8	-0.7
Happiness	1.6	1.9	5.4	0.9	-0.3	-2.3	-0.0	-0.9	-2.3	-1.2	-1.4	-1.9	0.4
Noisy workplace	1.0	1.2	2.5	0.6	-0.6	1.0	1.0	1.6	1.4	1.6	-0.1	-0.3	1.5
Qualifications: A levels/AS levels or equivalent	1.9	4.1	10.6	-0.3	0.6	-2.8	-1.6	-2.6	-2.8	-3.3	-1.2	-1.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	-0.9	0.0	0.2	-0.8	1.5	0.7	0.5	1.1	0.5	-1.0
Mouth/teeth dental problems: Dentures	1.9	3.3	9.5	-3.0	0.3	-2.0	-3.1	-1.2	-1.6	-2.2	0.4	0.8	0.8
Asthma	0.3	0.5	1.5	0.3	-0.7	-1.2	-0.8	-1.2	-0.8	-0.5	-0.1	-0.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.7	0.1	0.1	1.0	1.3	1.3	0.6	0.0	0.0	0.2	0.2
Medication: Cholesterol lowering	1.0	1.5	4.6	1.1	-1.6	1.0	1.8	0.7	0.7	1.2	0.2	-0.2	2.1
Depression (self-reported)	0.8	0.9	2.9	1.7	-1.3	-0.7	0.9	-1.2	0.4	0.7	-0.2	-0.6	-0.8
Medication: Lansoprazole	1.2	1.3	3.4	0.2	0.3	1.8	0.8	0.0	1.6	1.6	0.4	1.2	1.6
Prospective memory result	0.3	0.4	1.6	0.9	-0.1	0.1	1.3	0.7	-0.1	-0.3	-0.6	-0.8	-0.2
Lung cancer (father)	2.4	2.8	8.6	-0.5	0.1	2.0	-0.3	1.5	2.4	2.9	2.4	0.2	-1.3
Illnesses of mother	0.9	1.1	5.4	-1.3	-0.0	0.7	-0.1	2.3	0.4	-0.2	1.6	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.7	1.9	-0.4	-1.4	0.8	-1.0	-0.9	-0.2	-1.9	-0.8	-1.4
Pulse wave Arterial Stiffness index	1.3	1.5	4.2	-1.3	1.0	1.6	-0.2	1.7	1.3	0.6	2.0	0.7	-0.3
Impedance of arm (left)	1.5	6.7	18.3	-1.0	-0.6	-4.3	-1.9	-2.5	-4.2	-4.1	-1.1	-1.3	-0.4
Arm fat mass (right)	0.8	3.2	8.7	0.1	-0.7	2.0	-0.0	0.8	2.3	2.7	3.0	2.4	0.3
Trunk predicted mass	0.4	2.3	6.5	2.5	-1.1	-0.2	1.4	-0.8	0.7	2.2	-0.7	-0.6	-2.5
Standing height	1.3	13.4	28.5	4.0	-1.6	-5.3	1.0	-4.0	-4.6	-2.7	-4.1	-3.0	-3.8
Length of working week for main job	0.2	0.3	1.6	0.2	-0.1	-0.5	-0.2	-0.1	0.3	0.6	1.3	-0.2	-0.3
Exposure to tobacco smoke at home	0.3	0.3	1.4	-0.2	0.5	-0.0	-1.0	-0.5	0.1	0.3	0.3	1.2	-0.6
Breastfed as a baby	0.3	0.3	1.2	-0.8	-0.0	0.2	-0.5	1.1	-0.5	-0.1	0.2	-0.7	-0.3
Tense / ‘highly strung’	0.9	1.4	4.4	-1.1	0.3	1.2	-0.8	1.0	1.2	1.2	2.1	1.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.5	0.0	-1.2	-1.2	-0.5	0.4	-0.2	0.5	-0.4	-0.5	-0.2
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	-1.4	-0.2	0.6	-0.9	-0.1	1.1	1.7	0.6	1.4	0.8
Birth weight of first child	1.5	2.7	6.7	-0.4	0.8	2.3	-0.1	1.1	2.0	1.3	1.4	2.6	2.2
Peak expiratory flow (PEF)	0.4	0.9	4.3	-0.7	-0.4	0.6	-0.7	-0.1	0.9	1.4	0.7	0.4	-2.1
Pulse wave reflection index	0.7	0.9	2.9	-0.5	1.0	1.1	0.5	1.7	-0.2	-1.0	0.1	-0.3	1.5
Ever highly irritable/argumentative for 2 days	4.0	4.8	13.6	-3.2	0.5	1.7	-2.5	1.0	1.0	0.8	3.1	3.7	1.5
Loud music exposure frequency	0.5	0.5	1.6	-0.0	-1.3	0.1	0.3	1.2	0.4	1.2	-0.5	0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.6	-0.6	-0.1	-1.7	-1.6	-1.2	-2.1	-2.1	-0.6	-0.2	-1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.5	0.1	1.2	0.3	0.0	0.0	0.4	-0.3	0.5	0.6	0.5
Blood clot in the leg (DVT)	0.4	0.6	1.6	1.3	1.2	-0.7	0.0	-0.6	-0.5	-0.7	-1.0	0.4	0.5
Medication: Paracetamol	0.7	1.2	3.9	-0.9	-1.7	0.9	0.0	0.8	1.0	2.0	0.1	0.6	1.2
Headache pain in last month	1.7	2.9	7.8	-0.7	-1.2	2.8	0.4	0.3	2.3	2.5	2.1	1.6	0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	5.0	-1.8	1.6	-1.9	-2.2	-1.0	-0.9	-1.2	-0.2	-0.7	-2.2
Glaucoma (self-reported)	0.3	0.4	0.8	0.5	-0.9	-0.9	-0.2	-0.6	-0.7	-0.3	-0.4	-0.2	-0.8
Gout (self-reported)	6.3	8.6	33.7	4.6	-2.6	1.9	5.8	0.4	2.0	3.3	-2.0	-1.2	0.4
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.2	0.7	0.4	1.6	1.2	2.3	1.5	1.5	0.9	-0.5	-2.1
Medication: Amlodipine	0.6	0.8	2.5	1.6	-0.7	-0.6	0.7	-0.5	-1.1	-0.5	-0.8	0.5	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	-0.5	-0.2	-1.0	-0.8	-0.7	-0.8	-0.3	-0.4	-0.8	-0.2
Birth weight	0.6	1.3	3.9	-1.2	-0.6	-1.2	-2.0	-1.1	-1.2	-1.1	0.1	-0.7	-1.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	2.6	0.1	0.3	-0.2	-0.5	-0.5	-0.3	-0.2	-1.0	0.3	1.6
High blood pressure (siblings)	0.4	0.6	3.2	-0.9	-1.8	-0.3	-1.0	0.0	-0.6	-0.1	0.2	0.6	-0.0
Forced vital capacity (FVC), Best measure	1.4	5.2	9.6	2.5	-0.6	-3.1	0.8	-2.4	-2.8	-1.9	-3.1	-1.8	-2.3
Body fat percentage	0.7	2.8	9.7	-0.3	0.2	1.7	-0.5	0.9	1.5	1.2	3.1	2.9	1.3
Leg fat percentage (right)	1.0	3.5	12.6	-0.8	0.4	2.1	-0.8	1.1	2.0	1.6	3.6	2.9	0.9
Arm fat-free mass (right)	0.3	1.6	6.4	2.5	-0.5	0.7	1.4	-0.3	1.1	1.9	-0.1	0.8	-1.2
Exposure to tobacco smoke outside home	0.5	0.7	3.6	0.3	0.4	1.0	-0.4	0.0	0.4	0.1	0.8	1.9	1.1
Comparative body size at age 10	0.3	0.8	3.1	-1.0	-0.2	-0.7	-1.8	-0.3	0.4	0.8	1.2	0.3	-1.1
Number of full brothers	1.5	1.9	3.8	0.2	0.6	1.8	1.2	1.6	1.6	1.3	1.0	1.9	1.6
Worry too long after embarrassment	0.3	0.4	1.8	0.7	1.1	0.5	0.6	-0.1	0.6	-0.1	0.2	0.4	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	5.6	1.8	-2.4	-1.2	1.7	1.4	-1.2	0.1	-1.4	-2.0	-0.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.9	-0.8	-0.3	0.7	-0.6	-0.6	0.0	-0.7	-0.6	-0.4
Number of children fathered	1.2	1.3	3.7	-0.6	-1.0	-1.2	-0.4	-0.2	-1.2	-0.5	-1.6	-1.4	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	6.4	-0.2	0.9	-1.2	-0.9	-2.4	-1.5	-2.5	-0.9	-0.0	0.5
Age at first live birth	0.7	1.3	3.2	-1.0	-1.6	-0.6	-1.6	-1.8	-0.7	-0.2	1.1	0.2	-1.3
Pulse wave peak to peak time	1.7	1.9	5.0	1.6	-0.9	-1.8	0.4	-2.0	-1.5	-0.7	-2.2	-1.0	0.0
Health satisfaction	1.1	1.5	3.0	1.3	-1.2	1.2	1.6	1.7	0.9	1.7	0.7	0.5	0.3
Shortness of breath walking on level ground	1.9	2.2	6.6	-1.0	0.9	2.0	-0.4	2.6	1.2	0.5	2.0	1.9	0.3
Qualifications: College or University degree	0.4	1.3	2.9	1.4	-0.6	-1.5	0.6	-1.7	-1.3	-1.3	-0.7	-1.0	-0.4
Eye problems/disorders: None of the above	1.0	1.2	3.8	-1.7	2.0	0.3	-1.6	-0.5	0.6	-0.3	0.8	-0.4	-1.0
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.0	-0.1	0.1	-1.3	-1.1	-0.3	-1.8	-2.2	-1.4	-0.1	1.4
Emphysema/chronic bronchitis	0.4	0.5	2.0	-0.1	-1.4	-0.4	-0.5	0.5	-0.2	0.0	0.4	-1.1	-0.9
Medication for pain relief, constipation, heartburn	1.5	2.5	5.8	0.2	1.0	-2.0	-1.0	-1.8	-2.1	-2.4	-1.4	-1.6	-1.1
Neck or shoulder pain in last month	0.6	0.9	2.9	-0.1	0.7	1.7	0.3	-1.4	1.4	0.9	0.6	0.6	0.4
Medication: Blood pressure	0.6	1.0	4.1	2.0	-0.1	1.1	1.4	-1.1	0.4	0.4	0.1	0.5	0.8
Angina (self-reported)	1.5	2.0	5.2	-1.0	-0.2	1.0	-0.5	-0.6	1.5	1.9	2.1	2.3	1.2
Migraine (self-reported)	1.0	1.3	4.1	-1.8	-0.1	0.4	-1.7	0.0	0.6	1.2	2.0	0.1	-0.8
Medication: Ibuprofen	0.2	0.3	0.9	-0.1	-0.2	0.6	0.6	1.0	0.0	0.0	-0.1	-0.6	-0.6
Medication: Allopurinol	6.2	8.2	34.4	4.3	-1.4	2.3	5.9	1.3	2.2	3.0	-2.0	-1.6	0.8
Medication: Omeprazole	0.6	0.8	3.6	-0.1	-1.9	0.5	0.2	1.1	0.7	0.6	-0.7	-0.1	1.1
Medication: Seretide 50 evohaler	0.4	0.5	1.5	0.7	0.2	-0.6	0.5	-1.1	-0.7	-0.6	-1.2	-0.6	-0.0
Mean time to correctly identify matches	0.5	1.0	3.0	-1.7	-0.3	-0.3	-1.7	-0.9	0.2	0.4	1.4	0.8	-0.7
Heart disease (mother)	0.7	0.9	3.1	1.8	1.3	0.0	1.2	-0.9	-0.0	-0.5	-0.8	-0.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.2	0.3	-0.0	-0.6	0.0	-1.1	0.2	-0.4	-0.2	-0.3	0.1
Whole body fat mass	0.5	2.3	7.3	0.5	-0.3	1.4	-0.2	0.4	1.5	1.8	2.7	2.7	0.5
Leg fat mass (right)	0.9	3.6	10.3	0.3	-0.1	2.1	-0.0	1.0	2.2	2.3	3.2	3.1	0.4
Arm predicted mass (right)	0.3	1.4	5.9	2.4	-0.2	0.5	1.3	-0.5	1.0	1.7	-0.2	0.7	-1.4
Pulse rate, automated reading	1.2	3.7	7.7	0.4	0.4	2.5	1.0	2.5	2.8	2.5	2.2	0.9	-2.0
Alcohol intake frequency.	3.8	8.8	23.4	2.9	1.3	4.8	4.0	2.7	3.7	3.9	1.2	1.0	0.3
Comparative height size at age 10	1.9	10.6	26.1	2.0	-2.2	-5.1	-0.6	-3.3	-4.9	-3.4	-4.2	-2.4	-0.8
Number of full sisters	2.9	3.5	10.1	-0.1	1.4	1.9	0.8	1.2	3.2	2.6	2.3	2.2	0.4
Suffer from ‘nerves’	1.2	1.9	4.3	0.2	1.6	2.1	0.8	0.4	2.0	1.1	1.9	1.6	0.2
Overall health rating	1.5	3.3	8.1	-1.4	-0.6	1.7	-0.6	1.1	2.3	2.8	2.8	2.1	0.5
Chest pain or discomfort	1.1	1.6	3.9	-0.3	0.8	2.0	0.7	1.2	1.9	1.6	1.7	0.5	0.3
Had major operations	0.4	0.5	1.4	-1.2	-0.6	0.6	-0.6	0.3	0.5	1.1	0.5	0.4	0.4
Age at last live birth	0.3	0.5	1.3	-0.8	-0.7	-0.3	-1.1	-1.0	0.1	0.4	0.5	-0.1	-1.1
Family relationship satisfaction	0.4	0.5	1.2	0.3	-1.0	-0.1	0.1	0.7	-0.3	1.0	0.3	-1.1	-1.0
Leg pain on walking	1.0	1.2	2.8	0.9	1.3	1.3	1.1	1.7	1.2	0.8	0.8	1.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	2.0	0.5	-1.4	-0.8	0.3	-0.8	-0.6	-0.3	-0.9	-0.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.1	1.3	5.0	0.9	-0.3	1.1	1.6	0.3	1.1	0.6	-0.9	1.0	2.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.9	-0.5	-1.0	-2.0	-0.6	-1.4	-2.2	-1.8	-1.2	-1.8	-0.7
Medication: Aspirin	0.2	0.2	0.5	0.7	0.6	0.6	0.5	-0.3	-0.1	-0.2	0.6	-0.0	0.6
Supplements: Vitamin C	0.4	0.4	1.8	0.4	0.7	-0.4	0.8	0.5	-0.3	-0.6	0.1	-0.5	-1.4
Knee pain experienced in last month	0.3	0.5	1.7	-0.3	0.5	-0.7	-1.1	-0.9	-0.1	0.3	1.3	0.2	-0.6
Hypertension (Self-reported)	0.4	1.0	5.4	2.3	1.0	0.3	1.9	-0.5	0.2	0.0	-0.4	-0.1	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	10.7	0.3	0.8	1.6	1.3	3.3	1.3	0.2	0.3	-0.0	1.1
Illnesses of father: Heart disease	1.2	1.7	3.3	-0.3	-1.7	-1.2	-0.6	1.2	-1.8	-1.8	-1.3	-1.6	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	2.9	-0.1	0.5	0.7	0.7	0.6	0.6	0.0	0.4	1.1	1.7
Smoking status: Previous	2.9	4.3	10.1	-0.6	-1.1	-3.0	-1.1	-2.7	-3.2	-3.0	-1.9	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.7	1.6	-0.6	-0.8	0.6	-0.3	-1.2	-0.6	-1.3	-0.3	-1.9
Whole body fat-free mass	0.3	1.9	5.5	2.3	-1.2	0.2	1.0	-0.6	1.0	2.4	-0.1	0.1	-2.0
Leg fat-free mass (right)	0.2	1.3	4.5	1.6	-1.4	0.2	0.0	-0.6	0.9	2.1	0.6	0.9	-1.5
Arm fat percentage (left)	0.9	3.7	11.3	-0.8	-0.5	1.9	-0.7	1.0	2.0	2.0	3.4	3.0	1.5
Average weekly red wine intake	1.2	1.8	4.3	-0.7	-0.1	-2.0	-1.7	-0.4	-2.1	-2.0	-1.4	-0.8	0.0
Handedness (chirality/laterality): Left-handed	1.5	1.8	6.5	-0.6	1.3	-1.4	-1.9	-2.5	-1.3	-1.0	0.2	-0.5	-1.1
Mood swings	1.0	1.7	4.3	-1.6	-1.1	1.4	-0.5	1.0	1.2	2.1	1.8	0.9	0.6
Loneliness, isolation	0.9	1.2	3.5	1.9	-1.6	0.5	1.6	0.1	0.5	1.2	0.4	-0.4	-1.2
Long-standing illness, disability or infirmity	1.9	3.0	7.6	-0.9	-0.4	2.8	-0.1	0.2	2.3	2.5	1.9	1.6	1.8
Ever had bowel cancer screening	1.5	1.8	5.1	0.3	-0.6	-2.3	-0.3	-1.7	-1.4	-1.5	-0.6	-0.5	2.1
Diabetes diagnosed by doctor	2.4	3.9	14.0	-2.0	3.0	0.8	-2.1	1.0	1.1	-0.1	3.7	1.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.8	-0.6	0.5	1.2	-0.3	0.9	0.8	1.3	0.7	0.1	-1.2
Friendships satisfaction	0.3	0.4	1.4	-0.6	0.4	-0.7	-0.8	0.2	-0.5	-0.1	1.2	-0.0	-0.5
Qualifications: nursing, teaching	0.5	0.7	2.6	-0.1	0.0	-1.0	-1.0	-0.7	-0.8	-1.1	0.5	-0.2	-1.6
Commuting to job workplace: Walk	0.8	0.8	3.0	0.2	0.9	1.0	0.4	1.7	0.3	-1.0	0.5	-0.2	-1.4
Eye problems/disorders: Cataract	0.9	1.0	3.0	1.4	-1.5	-0.0	1.7	0.5	-0.4	0.0	-1.4	0.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	0.3	1.2	0.2	0.6	1.5	0.1	0.0	-0.5	-0.6	-0.7
Medication for cholesterol	0.4	0.5	1.4	-0.9	0.8	0.3	-1.1	-0.1	0.6	0.8	1.2	0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	4.0	2.0	0.1	-1.0	0.6	-0.8	-0.7	-0.9	-0.2	-0.6	0.3
Back pain experienced in last month	0.3	0.4	2.4	0.4	-1.5	0.2	0.4	0.8	-0.4	-0.6	-0.4	0.1	0.3
Mineral and other dietary supplements	1.1	1.4	5.2	0.1	-0.3	2.3	0.3	0.8	1.5	1.7	1.5	0.9	-0.1
Breast cancer (self-reported)	0.6	0.7	1.3	0.2	0.9	1.1	0.5	0.9	0.9	0.4	1.1	1.0	0.6
Asthma (self-reported)	0.3	0.5	1.6	0.2	-0.7	-1.1	-0.8	-1.3	-1.0	-0.6	0.0	0.2	0.5
Osteoporosis (self-reported)	1.2	1.5	5.5	-0.8	0.1	-2.0	-0.9	0.4	-1.7	-2.4	-0.4	-0.7	0.5
Osteoarthritis (self-reported)	0.7	1.0	2.5	-0.0	1.6	-0.6	-1.0	-1.4	-0.5	-1.1	-0.5	0.9	1.1
Medication: Aspirin	0.1	0.2	0.5	0.6	0.3	0.4	0.1	-0.5	-0.4	-0.0	0.7	-0.5	-0.4
Medication: Gliclazide	1.0	1.2	4.7	-1.1	0.7	0.6	-0.8	0.2	1.3	1.0	2.2	1.0	-0.7
Illnesses of father: None of the above (group 1)	1.4	1.7	5.6	0.1	1.1	1.6	1.1	0.0	2.4	2.3	0.8	0.9	-0.1
Smoking status: Current	0.9	1.5	4.5	1.1	0.4	2.1	2.0	0.6	1.5	1.2	-1.0	0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.0	0.3	0.1	-1.3	-0.5	-1.4	-1.0	-0.5	-1.2	-1.2	0.2
Whole body water mass	0.3	2.0	5.8	2.4	-1.1	0.3	1.1	-0.6	1.1	2.4	-0.1	0.1	-2.0
Leg predicted mass (right)	0.3	1.4	4.6	1.6	-1.3	0.2	0.0	-0.6	0.9	2.1	0.6	0.9	-1.5
Arm fat mass (left)	0.7	3.0	7.9	0.0	-0.6	1.9	-0.2	0.9	2.1	2.4	2.8	2.6	0.7
Number of self-reported non-cancer illnesses	0.9	1.5	5.8	0.0	-0.9	1.5	0.8	1.4	1.0	0.9	0.5	1.3	2.4
Average weekly champagne plus white wine intake	0.6	0.8	3.3	-1.0	0.6	0.1	-1.2	-0.5	0.4	0.8	1.8	0.9	-0.3
Miserableness	0.1	0.1	0.5	0.3	0.5	0.1	-0.0	0.4	0.0	-0.2	0.7	-0.1	0.2
Guilty feelings	0.4	0.6	2.2	0.7	0.2	0.1	0.6	-0.9	1.0	1.5	0.7	0.4	-1.0
Wears glasses or contact lenses	1.9	2.2	6.0	0.7	-1.8	-2.5	0.4	-1.3	-1.7	-1.4	-1.9	-1.4	-0.0
Ever taken oral contraceptive pill	1.5	1.7	3.1	-1.7	0.4	1.3	-0.5	1.6	1.2	1.8	1.2	1.7	0.8
Hearing aid user	1.0	1.1	2.9	0.5	-0.6	-1.7	-0.8	-0.6	-1.6	-1.3	-0.7	-1.0	-0.8
Mother’s age at death	1.9	2.3	7.3	-0.3	-0.9	-2.7	-1.3	-0.1	-2.7	-2.1	-1.4	-0.0	0.3
Financial situation satisfaction	0.2	0.3	0.9	0.6	-0.7	-0.3	-0.1	0.4	-0.1	0.9	-0.2	-0.9	0.3
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	-0.9	0.3	0.7	-0.8	-0.3	1.0	1.0	1.4	0.4	0.0
Commuting to job workplace: Public transport	1.2	1.5	4.7	-0.0	-0.9	-2.2	-1.1	-1.4	-1.9	-1.1	0.2	-0.8	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	1.4	-0.9	-1.2	0.5	-0.4	-1.0	-0.5	-0.6	-0.1	-0.9
Medication: Blood pressure	1.0	1.9	3.6	1.3	0.9	-1.4	0.5	-0.9	-1.6	-1.6	-1.6	-1.6	-1.9
Pain type(s) experienced in last month: Hip pain	1.0	1.3	6.7	0.6	-0.5	-0.9	-0.0	-2.6	-0.7	-0.1	-1.5	-0.5	1.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.7	-0.5	-0.6	-1.6	-0.4	-1.4	-0.5	-0.3	-0.8	-0.3	0.9
High cholesterol (Self-reported)	1.4	2.5	5.2	0.0	-0.1	2.2	1.2	1.8	2.0	1.6	1.7	0.9	2.3
Medication: Bendroflumethiazide	0.6	0.9	4.2	0.9	-0.6	-0.3	0.6	-1.1	-0.4	0.2	-1.1	-0.9	-2.1
Medication: Paracetamol	0.5	0.9	2.9	-0.8	-1.7	0.5	-0.5	0.2	0.4	1.6	0.0	0.5	1.1
Medication: Lisinopril	0.7	1.0	2.9	0.6	-0.6	0.5	0.1	0.0	0.6	1.6	1.5	-0.8	-1.7
Medication: Atorvastatin	1.2	1.5	3.1	-1.4	-0.3	1.8	-0.3	1.7	1.3	1.0	1.6	1.1	0.4
Illnesses of father: High blood pressure	0.6	0.8	2.2	1.0	-1.5	-0.1	0.3	-0.4	-1.1	0.8	-0.2	-0.9	-1.4
Alcohol drinker status: Never	1.1	1.3	4.1	-1.7	2.0	1.4	-1.0	0.4	0.5	-0.5	0.7	0.9	0.8
Ever smoked	0.5	0.9	2.0	-0.1	-0.5	-1.3	0.4	-1.4	-1.2	-1.3	-1.2	-0.3	-0.5
Basal metabolic rate	0.3	1.8	6.0	2.1	-1.1	0.4	0.9	-0.5	1.3	2.5	0.4	0.5	-1.8
Leg fat percentage (left)	1.0	3.5	11.0	-0.8	0.5	2.1	-1.0	1.1	1.8	1.4	3.3	3.1	1.5
Arm fat-free mass (left)	0.4	2.1	7.0	2.7	-0.4	1.0	1.6	0.2	1.5	2.3	0.1	0.4	-1.7
Number of operations (self-reported)	0.3	0.4	1.2	0.6	0.4	0.2	1.1	0.9	0.1	-0.5	-0.5	-0.3	0.8
Average weekly beer plus cider intake	0.8	1.2	4.4	-2.1	-1.5	-0.1	-1.2	-1.0	0.6	1.1	0.5	0.0	-0.9
Irritability	0.2	0.3	1.1	-0.5	0.9	0.3	-0.1	0.4	0.2	0.5	1.0	0.3	0.5
Risk taking	1.0	1.5	8.1	-0.5	-0.6	-1.5	-0.0	0.5	-0.9	0.5	-1.0	-2.8	-1.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	-0.1	-0.7	-0.6	0.3	-0.8	-0.5	-0.5	-0.4	-0.3	-1.0
Fractured/broken bones in last 5 years	2.6	3.4	11.8	2.0	-0.8	-2.2	1.3	0.9	-1.8	-1.1	-2.0	-3.4	-0.9
Age started oral contraceptive pill	1.3	1.6	6.5	-0.6	0.4	-1.5	-1.4	-0.3	-1.8	-2.5	-0.3	-1.0	0.3
Diastolic blood pressure, automated reading	0.2	0.5	3.6	0.3	-0.5	-0.1	0.0	0.3	-0.1	0.8	0.4	-0.3	-1.9
Ever depressed for a whole week	0.7	0.8	2.4	-0.1	-1.2	-0.4	-1.1	1.6	-1.2	-0.0	-0.5	-0.7	-1.0
Unable to work because of sickness or disability	1.7	2.2	4.5	1.8	1.2	1.5	1.9	1.1	2.1	2.0	0.8	-0.2	-1.1
Commuting to job workplace: Cycle	0.3	0.3	2.1	0.1	1.4	-0.5	0.2	-0.0	-0.3	-0.5	-0.7	-0.4	-0.0
Myopia	1.0	1.4	4.0	-2.0	0.4	0.8	-0.8	0.0	1.5	0.6	0.8	1.0	2.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.1	-1.8	-0.5	-0.3	-1.4	0.6	-0.1	-0.0	0.3	-0.0	-0.1
Cholesterol lowering medication	0.4	0.6	1.5	-0.7	1.0	1.0	-0.3	1.2	0.5	-0.4	0.9	-0.3	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	3.6	-0.0	-1.2	0.7	0.3	0.9	0.6	0.2	-0.3	0.9	1.9
Pain experienced in last month	0.6	1.0	2.2	0.9	0.0	-1.2	0.0	0.6	-1.2	-1.5	-0.8	-1.3	-1.0
Supplements: Calcium	1.3	1.4	5.7	0.3	1.1	-1.8	0.1	0.7	-1.5	-2.4	-0.7	-0.7	0.8
Basal cell carcinoma (self-reported)	1.1	1.3	3.0	-1.3	1.2	-1.0	-1.1	-0.7	-1.0	-0.7	-0.5	-1.4	-1.7
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.3	-0.1	0.3	2.0	0.8	0.7	2.1	1.9	1.3	0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.0	0.9	1.4	-0.4	-0.2	-0.5	-0.1	-0.4	-0.6	0.6	0.7
Heart disease (siblings)	0.7	0.9	3.3	-0.1	-1.5	-0.2	0.5	1.0	0.0	0.4	-1.0	-0.8	1.8
Alcohol drinker status: Previous	0.6	0.7	1.7	1.2	0.7	0.8	0.7	-1.3	0.5	1.0	0.4	0.3	-1.1
Pack years of smoking	0.7	1.0	4.2	0.5	-0.2	0.5	1.0	2.0	0.9	1.2	1.1	0.1	-1.1
Impedance of whole body	0.9	4.7	16.6	-0.5	0.9	-3.3	-1.0	-1.7	-3.6	-4.1	-1.1	-1.0	-0.2
Leg fat mass (left)	0.9	3.7	10.7	0.1	0.0	2.2	-0.2	0.9	2.2	2.2	3.2	3.3	0.7
Arm predicted mass (left)	0.4	2.2	6.5	2.6	-0.5	1.0	1.7	0.3	1.6	2.4	0.1	0.4	-1.6