Hub : Genes

UBIAD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.1530 0.0610 5.7e-03 0.009 NA 0.003 NA -0.005 9.9e-02 NA 2.3e-01 NA 9.4e-01
2 GTEx Muscle Skeletal 0.0852 0.0381 4.7e-03 -0.001 NA 0.020 NA 0.003 3.7e-01 NA 3.8e-03 NA 1.5e-01
3 YFS Blood 0.0509 0.0162 1.2e-06 0.016 0.023 0.025 0.023 0.014 3.8e-06 3.6e-08 9.6e-09 2.7e-08 1.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 1.3 -1.2 0.0 -0.7
Bipolar Disorder or Schizophrenia 0.1 0.4 0.4 -0.6 0.6 0.6
Depressed Affect (Nagel 2018) 1.9 4.0 6.0 2.2 -1.0 -2.4
Depression (Nagel 2018) 3.5 5.2 6.8 2.3 -1.8 -2.6
Intelligence (Savage-Jansen 2018) 1.3 4.1 6.5 -2.5 1.1 2.2
Neuroticism (Nagel 2018) 0.8 1.9 5.2 2.3 -0.2 -0.6
Schizophrenia (2018) 0.3 0.5 1.6 -0.1 0.1 1.2
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.0 0.0 1.0
Worry (Nagel 2018) 0.8 1.7 4.6 2.1 0.5 0.6
Alzheimer’s Disease (in mother) 1.2 1.4 3.8 -0.0 0.5 -1.9
Alzheimer’s Disease (in father) 1.5 1.6 3.9 -0.9 -2.0 0.5
Alzheimer’s Disease (including proxy) 1.1 1.5 4.0 -0.2 -0.7 -2.0
Crohns Disease (2017) 0.6 1.3 3.2 0.9 1.8 0.1
Irritable Bowel Disease (IBD) 0.3 0.6 1.8 0.1 1.3 0.4
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.6 0.2 0.6
Major Depression (MDD) 1.2 1.4 3.5 1.9 0.6 -0.7
Reaction Time 1.7 3.2 6.1 0.2 1.9 -2.5
Verbal and Numeric Reasoning (VNR) 1.0 2.5 5.2 -2.3 0.6 1.3
Breast Cancer 0.2 0.5 0.6 0.8 0.6 -0.6
Ovarian Cancer 0.1 0.2 0.3 0.3 -0.5 0.4
Prostate Cancer 0.6 0.8 2.0 -1.4 0.6 -0.0
Age at First Birth 0.7 1.0 2.4 -0.4 1.5 -0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.1 0.6 -1.5 0.1
Coronary Artery Disease (CAD) 0.4 0.4 1.3 0.0 0.0 -1.1
Crohns Disease (2012) 0.2 0.4 1.1 1.1 0.0 0.2
Mean Putamen Volume 0.5 0.6 1.2 0.6 1.1 0.6
Fasting Glucose 0.4 0.4 1.2 1.1 -0.1 -0.4
HbA1C 0.4 0.4 1.2 -0.4 -0.1 1.1
HDL Cholesterol 0.2 0.3 0.3 0.6 -0.5 -0.5
LDL Cholesterol 0.2 0.3 0.6 -0.0 0.5 -0.8
Lupus 1.1 1.7 3.1 -0.4 1.4 1.8
Neuroticism (2016) 1.6 2.4 6.9 2.6 0.3 -0.4
Primary Biliary Cirrhosis 0.9 1.3 2.0 -1.4 -1.4 0.2
Rheumatoid Arthritis 0.2 0.3 0.6 0.4 -0.5 -0.7
Schizophrenia (2014) 0.5 1.1 2.3 -0.8 -0.4 1.5
Triglycerides 0.1 0.2 0.4 -0.4 -0.6 0.0
Type 2 Diabetes (T2D) (2012) 1.6 1.8 5.1 0.1 2.3 0.5
Ulcerative Colitis 0.2 0.3 0.9 -0.1 0.3 0.9
Blood Eosinophil Count 0.3 2.3 6.6 0.2 -0.5 -2.6
Blood Platelet Count 0.4 5.2 13.1 -1.0 3.6 -1.2
Blood Red Count 0.2 1.7 4.8 -2.2 0.6 -0.2
Blood White Count 0.3 2.3 6.0 -1.0 2.5 0.3
Heel T-Score 1.0 7.6 21.4 1.0 4.6 -0.5
BMI 0.8 4.6 13.6 -0.4 -3.7 -0.3
Height 0.5 10.3 29.8 -0.8 -5.5 0.6
Waist Hip Ratio (WHR) 1.6 7.1 15.6 -1.0 4.0 -2.2
Systolic Blood Pressure 1.8 8.9 25.1 -0.3 5.0 1.2
Smoking Status 0.6 1.3 3.3 -1.8 -0.6 -0.6
Allergy or Eczema 0.9 2.3 6.6 0.0 0.5 2.6
Cardiovascular Disease 0.4 1.2 2.7 0.4 1.6 1.0
Hypothyroidism (self reported) 1.3 3.0 5.4 -2.3 -1.6 1.1
Respiratory disease 0.2 0.5 1.2 -0.1 1.1 -0.3
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.3 0.3 1.1 -0.9
Lung FEV1/FVC ratio 0.5 2.5 6.4 1.0 2.5 -0.5
Lung FVC 0.3 1.6 4.0 -0.2 -0.8 2.0
Neuroticism 0.1 0.4 0.8 0.9 0.1 -0.5
Chronotype (morning person) 0.5 1.1 1.7 0.6 1.3 -1.1
Hair Pigment 0.3 7.5 19.7 0.0 -1.7 -4.4
Tanning 0.1 0.8 2.3 -0.4 -0.1 -1.5
Hand grip strength (left) 0.2 0.5 0.8 -0.9 0.0 0.9
Number of treatments/medications taken 0.1 0.1 0.3 0.2 0.3 -0.6
Average weekly spirits intake 0.4 0.6 0.9 -1.0 0.8 0.2
Sensitivity / hurt feelings 1.6 2.7 4.8 2.2 1.6 -0.8
Frequency of depressed mood in last 2 weeks 1.4 2.0 4.4 0.2 -2.1 -1.3
Hearing difficulty/problems: Yes 2.0 3.0 8.2 0.8 -0.3 2.9
Relative age of first facial hair 0.4 0.8 1.3 -0.6 0.9 1.1
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.3 -0.3 0.6 -0.2
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.4 -0.6 -0.3 -2.3
Ever had hysterectomy (womb removed) 2.1 2.3 2.7 1.5 -1.6 -1.4
Systolic blood pressure, automated reading 1.4 4.2 11.4 -0.3 3.4 -1.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.5 1.2 -0.1 -0.1
Angina 0.2 0.2 0.3 0.3 0.6 0.5
Medication for hormone replacement therapy 0.8 0.8 1.4 -0.0 -1.1 -1.2
Vitamin and mineral supplements 0.5 0.6 1.0 0.9 0.2 -1.0
Supplements: Zinc 1.0 1.1 2.3 -1.5 0.0 -1.0
Medication: Co-codamol 0.7 0.8 1.1 -0.8 -1.1 0.8
Medication: Metformin 2.0 2.9 4.8 -1.5 1.2 -2.2
Diabetes (father) 0.9 1.2 2.2 1.5 1.0 -0.5
Diabetes (mother) 1.6 2.0 4.8 -2.2 0.7 -0.9
Severe depression (siblings) 0.9 1.0 1.9 -0.2 -1.1 -1.4
Pack years adult smoking proportion 0.2 0.3 0.7 0.5 -0.2 0.8
Impedance of leg (right) 0.7 3.4 6.8 1.3 2.6 -1.4
Leg fat-free mass (left) 1.4 7.4 20.8 -1.2 -4.6 0.2
Trunk fat percentage 0.3 1.1 2.1 -0.3 -1.5 -1.1
Hand grip strength (right) 0.6 1.6 1.8 -1.2 -1.2 1.3
Townsend deprivation index at recruitment 0.7 1.0 2.9 -1.7 0.2 -0.4
Current tobacco smoking 0.2 0.3 0.8 -0.9 0.0 0.4
Average weekly fortified wine intake 1.2 1.3 4.0 -2.0 -0.0 -0.3
Maternal smoking around birth 0.3 0.5 1.3 0.1 -1.2 0.0
Fed-up feelings 3.0 5.5 6.9 2.2 -2.1 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 4.1 2.0 -0.3 -1.9
Relative age voice broke 0.3 0.4 0.7 -0.7 0.1 0.8
Taking other prescription medications 0.2 0.2 0.5 -0.5 -0.1 -0.7
Age when periods started (menarche) 1.5 3.6 10.1 0.7 3.2 -0.1
Bilateral oophorectomy (both ovaries removed) 3.1 3.5 7.5 2.7 -0.2 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.7 0.2 1.6 0.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.3 -1.1 -0.7 -0.3
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.5 -0.0 0.5
Serious illness, injury or assault to yourself 0.6 0.7 1.7 1.3 0.5 -0.3
High blood pressure 0.4 1.2 2.6 0.4 1.6 0.9
Hayfever, allergic rhinitis or eczema 1.0 2.2 5.4 -0.7 0.9 2.3
Multivitamins +/- minerals 0.1 0.1 0.3 -0.6 0.2 0.2
Stomach or abdominal pain in last month 0.4 0.5 1.4 1.2 -0.5 0.2
Supplements: Glucosamine 0.8 1.0 2.0 0.1 -1.0 1.4
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 4.3 -0.5 2.1 0.9
Medication: Atenolol 1.0 1.2 2.1 1.0 1.5 0.7
Medication: Levothyroxine sodium 1.3 2.2 6.0 -2.4 -0.9 0.1
Sitting height 0.8 5.9 14.6 -1.2 -3.8 1.2
Chronic bronchitis/emphysema (father) 0.1 0.2 0.5 -0.1 0.0 0.7
High blood pressure (mother) 0.2 0.2 0.6 0.0 0.3 0.8
Body mass index (BMI) 0.5 2.2 6.4 -0.4 -2.5 -0.3
Impedance of leg (left) 0.8 4.1 8.6 1.4 2.9 -1.3
Leg predicted mass (left) 1.4 7.2 19.9 -1.2 -4.5 0.2
Trunk fat mass 0.6 2.7 7.1 -0.7 -2.7 -0.8
Waist circumference 0.3 1.0 1.5 -1.1 -1.2 -0.6
Number of incorrect matches in round 0.1 0.2 0.4 -0.5 0.2 0.7
Past tobacco smoking 0.6 1.1 1.9 1.1 1.4 0.5
Alcohol usually taken with meals 0.1 0.1 0.4 0.2 0.6 0.1
Nervous feelings 0.6 1.2 3.4 1.8 -0.3 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.6 1.3 -0.1 -0.3
Hearing difficulty/problems with background noise 1.2 1.8 2.5 1.6 1.1 1.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.1 0.1 0.4
Had menopause 1.1 1.3 3.3 0.7 0.5 -1.8
Had other major operations 0.6 0.8 2.2 1.5 -0.3 -0.2
Forced vital capacity (FVC) 1.2 4.7 9.3 -1.8 -3.0 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.5 0.7 0.2 -0.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.1 -0.4 -1.8 0.1
Qualifications: None of the above 0.1 0.2 0.3 0.3 0.1 -0.6
Financial difficulties in last 2 years 0.1 0.1 0.1 -0.2 -0.3 0.3
Mouth/teeth dental problems 0.6 0.9 2.0 -0.7 1.4 -0.5
Heart attack 0.0 0.0 0.1 -0.1 -0.2 -0.1
Allergy 0.4 1.0 1.6 0.7 -1.0 -1.3
Pain all over the body in last month 0.8 0.9 1.5 1.2 -0.9 -0.6
Diabetes (self-reported) 1.4 2.1 5.0 -0.7 0.9 -2.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 2.3 -0.5 0.7 1.5
Medication: Ramipril 0.1 0.2 0.3 0.5 -0.2 0.5
Medication: Simvastatin 0.4 0.6 1.3 -0.4 1.2 -0.6
Fluid intelligence score 1.2 2.5 6.0 -2.4 -0.1 1.2
Illnesses of siblings 0.2 0.2 0.4 0.2 -0.7 -0.5
Neuroticism score 0.6 1.2 3.4 1.8 -0.4 -0.0
Weight 1.3 6.5 19.1 -0.7 -4.4 -0.0
Impedance of arm (right) 0.5 2.2 6.5 -0.3 2.5 0.0
Arm fat percentage (right) 0.4 1.5 3.7 -0.8 -1.9 -0.3
Trunk fat-free mass 1.6 9.2 25.4 -1.4 -5.0 0.5
Hip circumference 1.0 4.2 12.2 -0.3 -3.5 0.4
Time employed in main current job 0.3 0.4 0.5 0.7 0.6 -0.5
Alcohol intake versus 10 years previously 0.3 0.4 1.0 0.2 -0.4 -1.0
Father’s age at death 0.6 0.8 1.9 1.4 -0.4 0.5
Worrier / anxious feelings 2.2 4.1 10.2 3.2 0.5 1.4
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 5.0 2.2 -0.5 -0.7
Falls in the last year 0.8 1.1 2.0 1.4 -1.1 -0.1
Hair/balding pattern: Pattern 3 0.4 0.5 0.9 -0.1 1.0 0.8
Number of live births 1.4 2.0 5.2 2.3 0.9 -0.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 3.1 -1.1 -1.8 1.3
Pulse rate 0.2 0.3 0.4 0.6 0.4 0.6
Happiness 2.0 2.4 6.0 1.0 -2.5 -0.5
Noisy workplace 1.1 1.4 2.4 1.5 -0.5 -1.2
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.7 -1.6 0.7 1.0
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.8 6.9 -0.2 1.1 2.6
Mouth/teeth dental problems: Dentures 1.4 2.4 3.5 1.9 -1.2 1.5
Asthma 1.0 1.9 3.0 -1.6 1.7 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.0 0.1 -0.1 -1.4
Medication: Cholesterol lowering 0.2 0.3 0.5 -0.2 0.7 0.5
Depression (self-reported) 1.6 1.9 4.9 -0.6 -0.6 -2.2
Medication: Lansoprazole 1.0 1.1 2.0 0.6 1.0 -1.4
Prospective memory result 2.5 3.0 4.7 0.0 -2.2 -2.1
Lung cancer (father) 0.5 0.6 1.7 -0.2 1.3 0.3
Illnesses of mother 0.7 0.9 1.9 0.7 -0.5 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.9 -1.1 -2.0 0.5
Pulse wave Arterial Stiffness index 0.8 0.9 1.8 1.3 0.6 0.8
Impedance of arm (left) 0.4 1.9 5.5 0.0 2.4 -0.2
Arm fat mass (right) 0.7 3.0 8.6 -0.6 -2.9 -0.3
Trunk predicted mass 1.6 8.9 24.4 -1.4 -4.9 0.6
Standing height 0.6 6.4 17.8 -1.1 -4.2 0.6
Length of working week for main job 1.7 1.9 3.1 1.8 -0.4 -1.6
Exposure to tobacco smoke at home 1.3 1.4 1.8 1.0 -1.3 -1.2
Breastfed as a baby 0.3 0.3 0.5 -0.7 0.4 0.6
Tense / ‘highly strung’ 0.3 0.5 1.0 0.1 -0.6 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 6.5 -1.5 -0.0 -2.5
Hair/balding pattern: Pattern 4 2.0 4.7 10.3 0.0 2.0 3.2
Birth weight of first child 0.4 0.8 1.6 1.3 0.4 -0.7
Peak expiratory flow (PEF) 0.6 1.4 2.7 -1.6 -0.2 1.2
Pulse wave reflection index 1.7 2.2 3.1 1.8 1.5 1.1
Ever highly irritable/argumentative for 2 days 1.5 1.8 3.1 1.8 -0.1 -1.5
Loud music exposure frequency 0.4 0.4 0.6 0.6 -0.5 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.2 -0.0 -0.7 1.1
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 3.1 -1.8 -1.2 -0.4
Blood clot in the leg (DVT) 0.6 0.7 1.1 0.4 -1.1 0.9
Medication: Paracetamol 1.1 1.7 2.9 1.4 1.7 -0.7
Headache pain in last month 0.0 0.0 0.1 -0.3 -0.2 0.0
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.6 0.2 -1.3 -1.0
Glaucoma (self-reported) 0.4 0.5 1.2 1.1 -0.2 -0.5
Gout (self-reported) 0.2 0.2 0.6 0.8 0.1 0.0
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 4.8 -2.2 -1.6 -0.3
Medication: Amlodipine 1.2 1.7 4.1 0.8 2.0 0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.4 -0.6 0.2 1.2
Birth weight 0.2 0.4 0.6 0.8 -0.5 -0.6
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.9 -0.4 0.5 -0.9
High blood pressure (siblings) 0.2 0.3 0.5 0.6 0.7 -0.4
Forced vital capacity (FVC), Best measure 1.1 4.1 9.9 -1.5 -3.1 0.5
Body fat percentage 0.3 1.3 2.8 -0.3 -1.7 -1.0
Leg fat percentage (right) 0.4 1.5 4.0 -0.1 -2.0 -0.8
Arm fat-free mass (right) 1.3 6.6 19.0 -0.8 -4.4 -0.3
Exposure to tobacco smoke outside home 1.6 2.2 4.5 2.1 1.0 -1.1
Comparative body size at age 10 0.9 2.4 6.6 2.6 0.0 0.7
Number of full brothers 0.6 0.8 1.8 -0.7 -0.3 1.4
Worry too long after embarrassment 0.7 1.2 2.1 1.4 0.8 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.1 -0.1 -0.5 -1.0
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 0.5 0.6 0.2
Number of children fathered 0.1 0.1 0.1 0.3 0.3 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.5 -1.2 -0.4 -0.9
Age at first live birth 0.3 0.5 1.5 0.2 1.2 -0.1
Pulse wave peak to peak time 1.0 1.1 1.7 -1.3 -1.0 -0.8
Health satisfaction 0.6 0.7 2.0 1.4 -0.3 0.2
Shortness of breath walking on level ground 0.4 0.5 1.4 1.2 -0.2 0.1
Qualifications: College or University degree 0.9 2.9 6.6 -2.6 -1.5 -0.3
Eye problems/disorders: None of the above 0.5 0.6 0.9 -0.3 1.0 0.9
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 -0.2 0.3 0.2
Emphysema/chronic bronchitis 0.4 0.4 1.1 0.0 0.4 -1.1
Medication for pain relief, constipation, heartburn 1.3 2.1 3.0 -1.5 -1.7 1.1
Neck or shoulder pain in last month 0.1 0.1 0.2 0.3 0.0 0.4
Medication: Blood pressure 1.2 2.0 4.7 0.5 2.2 1.1
Angina (self-reported) 0.2 0.3 0.4 0.7 0.5 0.5
Migraine (self-reported) 2.0 2.5 5.4 -2.3 -0.9 1.1
Medication: Ibuprofen 1.7 2.0 6.0 -0.1 -0.3 -2.4
Medication: Allopurinol 0.4 0.5 0.7 0.6 -0.8 0.7
Medication: Omeprazole 1.9 2.3 6.2 2.5 0.4 0.8
Medication: Seretide 50 evohaler 1.3 1.5 3.9 -2.0 0.4 -0.6
Mean time to correctly identify matches 1.5 2.9 4.9 0.3 1.9 -2.2
Heart disease (mother) 1.1 1.3 2.4 -1.6 -0.7 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 -1.0 -0.5 -0.7
Whole body fat mass 0.7 2.9 7.9 -0.5 -2.8 -0.8
Leg fat mass (right) 0.8 3.1 8.8 -0.1 -3.0 -0.7
Arm predicted mass (right) 1.1 5.7 16.9 -0.4 -4.1 -0.2
Pulse rate, automated reading 0.3 1.1 1.9 -0.1 1.1 -1.4
Alcohol intake frequency. 1.5 3.5 9.1 0.7 3.0 1.0
Comparative height size at age 10 1.2 6.4 18.5 0.7 -4.3 -0.5
Number of full sisters 0.5 0.6 1.4 -0.3 1.2 -0.6
Suffer from ‘nerves’ 0.2 0.3 0.5 0.7 0.4 0.4
Overall health rating 1.0 2.1 3.9 2.0 -0.5 -1.5
Chest pain or discomfort 1.1 1.6 2.2 1.5 1.1 1.2
Had major operations 0.1 0.1 0.4 -0.1 -0.0 -0.6
Age at last live birth 0.8 1.1 1.6 1.1 1.3 0.6
Family relationship satisfaction 0.5 0.6 1.0 0.9 -1.0 -0.2
Leg pain on walking 1.9 2.3 4.7 2.2 -1.1 1.0
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 6.3 1.6 2.5 -1.3
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.0 -0.5 0.1 -1.0
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.5 -0.0 0.2
Medication: Aspirin 0.7 0.9 2.0 -0.7 1.4 -0.5
Supplements: Vitamin C 1.5 1.8 3.4 -1.8 -0.7 1.2
Knee pain experienced in last month 0.9 1.4 3.3 -0.9 0.1 1.8
Hypertension (Self-reported) 0.7 2.0 3.8 1.1 1.9 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.3 0.6 1.1 0.2
Illnesses of father: Heart disease 0.3 0.4 0.9 -0.4 1.0 -0.3
Illnesses of siblings: Diabetes 0.6 0.7 1.2 -1.1 0.6 0.8
Smoking status: Previous 0.6 1.0 1.5 -0.8 -1.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 6.0 -2.4 -2.0 0.9
Whole body fat-free mass 1.4 8.2 22.7 -1.3 -4.8 0.3
Leg fat-free mass (right) 1.4 7.2 19.8 -1.3 -4.5 0.4
Arm fat percentage (left) 0.3 1.3 3.2 -0.7 -1.8 -0.5
Average weekly red wine intake 0.1 0.1 0.2 -0.2 0.4 0.5
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.0 -0.0 0.5 -1.0
Mood swings 0.5 0.9 1.8 1.3 -0.9 -0.4
Loneliness, isolation 0.4 0.5 1.3 0.5 -1.1 0.0
Long-standing illness, disability or infirmity 0.5 0.8 1.8 0.7 1.4 -0.3
Ever had bowel cancer screening 0.4 0.5 0.8 0.4 -0.7 0.9
Diabetes diagnosed by doctor 0.8 1.4 2.9 -0.6 0.9 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 0.9 -1.0 0.8 0.6
Friendships satisfaction 0.2 0.2 0.4 0.6 -0.4 0.3
Qualifications: nursing, teaching 1.8 2.8 5.6 -2.4 -0.3 -1.7
Commuting to job workplace: Walk 1.0 1.1 2.1 -1.4 0.7 -0.9
Eye problems/disorders: Cataract 1.2 1.4 2.1 -1.5 -0.8 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.1 -0.9 -1.8 0.4
Medication for cholesterol 0.1 0.2 0.4 0.6 -0.1 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.8 -0.3 -0.1 -1.4
Back pain experienced in last month 0.6 0.9 1.5 1.2 -0.8 -0.6
Mineral and other dietary supplements 0.6 0.9 1.6 -0.8 0.6 -1.2
Breast cancer (self-reported) 0.5 0.7 1.2 1.1 -0.9 0.0
Asthma (self-reported) 0.8 1.7 2.9 -1.4 1.7 0.3
Osteoporosis (self-reported) 0.4 0.5 1.4 -1.2 0.0 0.1
Osteoarthritis (self-reported) 0.1 0.2 0.5 -0.7 -0.1 0.2
Medication: Aspirin 0.5 0.6 1.2 -0.5 1.1 -0.5
Medication: Gliclazide 0.2 0.2 0.4 -0.3 -0.4 -0.6
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 -0.6 -0.9 -0.2
Smoking status: Current 0.3 0.5 0.8 -0.9 0.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 -0.6 -0.1 -0.1
Whole body water mass 1.4 8.2 23.1 -1.2 -4.8 0.2
Leg predicted mass (right) 1.3 7.2 19.5 -1.4 -4.4 0.4
Arm fat mass (left) 0.6 2.6 7.2 -0.7 -2.7 -0.4
Number of self-reported non-cancer illnesses 0.8 1.4 3.6 -1.9 0.4 0.7
Average weekly champagne plus white wine intake 1.1 1.6 2.3 -0.5 -1.5 -1.5
Miserableness 0.5 0.9 1.1 0.9 -1.1 -0.9
Guilty feelings 0.6 0.9 1.4 -1.0 -1.2 -0.4
Wears glasses or contact lenses 2.2 2.5 3.8 1.8 0.6 1.9
Ever taken oral contraceptive pill 2.4 2.6 3.9 -1.7 1.1 -2.0
Hearing aid user 1.0 1.1 2.1 0.9 0.6 1.5
Mother’s age at death 0.9 1.1 2.4 -0.4 -1.6 -0.9
Financial situation satisfaction 1.9 2.4 7.1 2.7 -0.1 0.2
Tinnitus: Yes, now most or all of the time 1.0 1.1 2.7 -0.9 0.1 -1.6
Commuting to job workplace: Public transport 0.3 0.4 0.9 -1.0 -0.4 0.3
Eye problems/disorders: Glaucoma 1.7 2.0 3.1 1.8 -0.9 -1.4
Medication: Blood pressure 0.4 0.7 1.2 0.9 0.3 1.1
Pain type(s) experienced in last month: Hip pain 1.0 1.2 3.0 1.7 0.4 0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.7 0.7 -0.6 1.3
High cholesterol (Self-reported) 0.6 1.1 1.9 -1.4 1.2 0.1
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.1 -0.4 0.4
Medication: Paracetamol 1.3 2.0 3.0 1.7 1.2 -1.3
Medication: Lisinopril 0.3 0.4 0.8 -0.9 -0.1 0.6
Medication: Atorvastatin 0.2 0.3 0.4 -0.6 -0.2 0.6
Illnesses of father: High blood pressure 1.6 2.0 3.2 1.8 1.5 -0.8
Alcohol drinker status: Never 2.2 2.6 4.5 -0.0 1.8 -2.1
Ever smoked 0.3 0.6 1.3 -0.6 -1.1 -0.2
Basal metabolic rate 1.5 8.5 23.9 -1.3 -4.9 0.2
Leg fat percentage (left) 0.4 1.3 3.1 -0.2 -1.7 -0.9
Arm fat-free mass (left) 1.2 6.0 17.6 -0.7 -4.2 0.0
Number of operations (self-reported) 1.1 1.6 2.3 1.5 -1.2 1.0
Average weekly beer plus cider intake 0.2 0.3 0.4 0.6 -0.3 -0.6
Irritability 0.3 0.5 1.3 0.2 -0.1 1.1
Risk taking 1.2 1.7 2.4 -1.3 -1.5 -1.0
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.3 -0.4 -1.8 -0.0
Fractured/broken bones in last 5 years 0.9 1.2 2.6 0.5 -1.6 -0.9
Age started oral contraceptive pill 1.0 1.3 3.6 0.2 1.9 0.3
Diastolic blood pressure, automated reading 0.8 2.5 5.7 -0.8 2.4 -1.1
Ever depressed for a whole week 0.3 0.4 0.9 0.3 -0.5 0.9
Unable to work because of sickness or disability 0.6 0.8 1.3 1.1 -1.1 -0.1
Commuting to job workplace: Cycle 1.1 1.3 1.6 -1.1 -1.3 1.0
Myopia 0.8 1.2 3.3 -1.8 -0.4 -0.1
Vascular/heart problems diagnosed by doctor 0.4 1.0 1.5 -0.2 -1.2 -1.2
Cholesterol lowering medication 0.2 0.3 0.6 -0.3 0.8 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 4.4 2.1 0.5 1.3
Pain experienced in last month 0.7 1.2 3.5 -0.2 0.3 -1.9
Supplements: Calcium 0.6 0.7 1.7 -1.3 -0.6 -0.2
Basal cell carcinoma (self-reported) 1.5 1.7 3.5 -0.3 1.9 1.3
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 -0.2 -0.2 0.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.2 0.2 -1.1 0.9
Heart disease (siblings) 0.8 0.9 1.6 1.3 1.0 -0.5
Alcohol drinker status: Previous 0.5 0.6 1.8 -0.3 1.3 -0.2
Pack years of smoking 0.3 0.5 0.8 0.9 -0.1 0.8
Impedance of whole body 0.7 3.5 9.1 0.8 3.0 -0.8
Leg fat mass (left) 0.7 2.6 7.2 -0.2 -2.7 -0.8
Arm predicted mass (left) 1.3 6.8 19.8 -0.7 -4.5 -0.1