Hub : Genes

UBIAD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1530	0.0610	5.7e-03	0.009	NA	0.003	NA	-0.005	9.9e-02	NA	2.3e-01	NA	9.4e-01
2	GTEx	Muscle Skeletal	0.0852	0.0381	4.7e-03	-0.001	NA	0.020	NA	0.003	3.7e-01	NA	3.8e-03	NA	1.5e-01
3	YFS	Blood	0.0509	0.0162	1.2e-06	0.016	0.023	0.025	0.023	0.014	3.8e-06	3.6e-08	9.6e-09	2.7e-08	1.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.3	-1.2	0.0	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.4	0.4	-0.6	0.6	0.6
Depressed Affect (Nagel 2018)	1.9	4.0	6.0	2.2	-1.0	-2.4
Depression (Nagel 2018)	3.5	5.2	6.8	2.3	-1.8	-2.6
Intelligence (Savage-Jansen 2018)	1.3	4.1	6.5	-2.5	1.1	2.2
Neuroticism (Nagel 2018)	0.8	1.9	5.2	2.3	-0.2	-0.6
Schizophrenia (2018)	0.3	0.5	1.6	-0.1	0.1	1.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.0	0.0	1.0
Worry (Nagel 2018)	0.8	1.7	4.6	2.1	0.5	0.6
Alzheimer’s Disease (in mother)	1.2	1.4	3.8	-0.0	0.5	-1.9
Alzheimer’s Disease (in father)	1.5	1.6	3.9	-0.9	-2.0	0.5
Alzheimer’s Disease (including proxy)	1.1	1.5	4.0	-0.2	-0.7	-2.0
Crohns Disease (2017)	0.6	1.3	3.2	0.9	1.8	0.1
Irritable Bowel Disease (IBD)	0.3	0.6	1.8	0.1	1.3	0.4
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	0.2	0.6
Major Depression (MDD)	1.2	1.4	3.5	1.9	0.6	-0.7
Reaction Time	1.7	3.2	6.1	0.2	1.9	-2.5
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.2	-2.3	0.6	1.3
Breast Cancer	0.2	0.5	0.6	0.8	0.6	-0.6
Ovarian Cancer	0.1	0.2	0.3	0.3	-0.5	0.4
Prostate Cancer	0.6	0.8	2.0	-1.4	0.6	-0.0
Age at First Birth	0.7	1.0	2.4	-0.4	1.5	-0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	0.6	-1.5	0.1
Coronary Artery Disease (CAD)	0.4	0.4	1.3	0.0	0.0	-1.1
Crohns Disease (2012)	0.2	0.4	1.1	1.1	0.0	0.2
Mean Putamen Volume	0.5	0.6	1.2	0.6	1.1	0.6
Fasting Glucose	0.4	0.4	1.2	1.1	-0.1	-0.4
HbA1C	0.4	0.4	1.2	-0.4	-0.1	1.1
HDL Cholesterol	0.2	0.3	0.3	0.6	-0.5	-0.5
LDL Cholesterol	0.2	0.3	0.6	-0.0	0.5	-0.8
Lupus	1.1	1.7	3.1	-0.4	1.4	1.8
Neuroticism (2016)	1.6	2.4	6.9	2.6	0.3	-0.4
Primary Biliary Cirrhosis	0.9	1.3	2.0	-1.4	-1.4	0.2
Rheumatoid Arthritis	0.2	0.3	0.6	0.4	-0.5	-0.7
Schizophrenia (2014)	0.5	1.1	2.3	-0.8	-0.4	1.5
Triglycerides	0.1	0.2	0.4	-0.4	-0.6	0.0
Type 2 Diabetes (T2D) (2012)	1.6	1.8	5.1	0.1	2.3	0.5
Ulcerative Colitis	0.2	0.3	0.9	-0.1	0.3	0.9
Blood Eosinophil Count	0.3	2.3	6.6	0.2	-0.5	-2.6
Blood Platelet Count	0.4	5.2	13.1	-1.0	3.6	-1.2
Blood Red Count	0.2	1.7	4.8	-2.2	0.6	-0.2
Blood White Count	0.3	2.3	6.0	-1.0	2.5	0.3
Heel T-Score	1.0	7.6	21.4	1.0	4.6	-0.5
BMI	0.8	4.6	13.6	-0.4	-3.7	-0.3
Height	0.5	10.3	29.8	-0.8	-5.5	0.6
Waist Hip Ratio (WHR)	1.6	7.1	15.6	-1.0	4.0	-2.2
Systolic Blood Pressure	1.8	8.9	25.1	-0.3	5.0	1.2
Smoking Status	0.6	1.3	3.3	-1.8	-0.6	-0.6
Allergy or Eczema	0.9	2.3	6.6	0.0	0.5	2.6
Cardiovascular Disease	0.4	1.2	2.7	0.4	1.6	1.0
Hypothyroidism (self reported)	1.3	3.0	5.4	-2.3	-1.6	1.1
Respiratory disease	0.2	0.5	1.2	-0.1	1.1	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.3	1.1	-0.9
Lung FEV1/FVC ratio	0.5	2.5	6.4	1.0	2.5	-0.5
Lung FVC	0.3	1.6	4.0	-0.2	-0.8	2.0
Neuroticism	0.1	0.4	0.8	0.9	0.1	-0.5
Chronotype (morning person)	0.5	1.1	1.7	0.6	1.3	-1.1
Hair Pigment	0.3	7.5	19.7	0.0	-1.7	-4.4
Tanning	0.1	0.8	2.3	-0.4	-0.1	-1.5
Hand grip strength (left)	0.2	0.5	0.8	-0.9	0.0	0.9
Number of treatments/medications taken	0.1	0.1	0.3	0.2	0.3	-0.6
Average weekly spirits intake	0.4	0.6	0.9	-1.0	0.8	0.2
Sensitivity / hurt feelings	1.6	2.7	4.8	2.2	1.6	-0.8
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.4	0.2	-2.1	-1.3
Hearing difficulty/problems: Yes	2.0	3.0	8.2	0.8	-0.3	2.9
Relative age of first facial hair	0.4	0.8	1.3	-0.6	0.9	1.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	-0.3	0.6	-0.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.4	-0.6	-0.3	-2.3
Ever had hysterectomy (womb removed)	2.1	2.3	2.7	1.5	-1.6	-1.4
Systolic blood pressure, automated reading	1.4	4.2	11.4	-0.3	3.4	-1.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.5	1.2	-0.1	-0.1
Angina	0.2	0.2	0.3	0.3	0.6	0.5
Medication for hormone replacement therapy	0.8	0.8	1.4	-0.0	-1.1	-1.2
Vitamin and mineral supplements	0.5	0.6	1.0	0.9	0.2	-1.0
Supplements: Zinc	1.0	1.1	2.3	-1.5	0.0	-1.0
Medication: Co-codamol	0.7	0.8	1.1	-0.8	-1.1	0.8
Medication: Metformin	2.0	2.9	4.8	-1.5	1.2	-2.2
Diabetes (father)	0.9	1.2	2.2	1.5	1.0	-0.5
Diabetes (mother)	1.6	2.0	4.8	-2.2	0.7	-0.9
Severe depression (siblings)	0.9	1.0	1.9	-0.2	-1.1	-1.4
Pack years adult smoking proportion	0.2	0.3	0.7	0.5	-0.2	0.8
Impedance of leg (right)	0.7	3.4	6.8	1.3	2.6	-1.4
Leg fat-free mass (left)	1.4	7.4	20.8	-1.2	-4.6	0.2
Trunk fat percentage	0.3	1.1	2.1	-0.3	-1.5	-1.1
Hand grip strength (right)	0.6	1.6	1.8	-1.2	-1.2	1.3
Townsend deprivation index at recruitment	0.7	1.0	2.9	-1.7	0.2	-0.4
Current tobacco smoking	0.2	0.3	0.8	-0.9	0.0	0.4
Average weekly fortified wine intake	1.2	1.3	4.0	-2.0	-0.0	-0.3
Maternal smoking around birth	0.3	0.5	1.3	0.1	-1.2	0.0
Fed-up feelings	3.0	5.5	6.9	2.2	-2.1	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	4.1	2.0	-0.3	-1.9
Relative age voice broke	0.3	0.4	0.7	-0.7	0.1	0.8
Taking other prescription medications	0.2	0.2	0.5	-0.5	-0.1	-0.7
Age when periods started (menarche)	1.5	3.6	10.1	0.7	3.2	-0.1
Bilateral oophorectomy (both ovaries removed)	3.1	3.5	7.5	2.7	-0.2	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.7	0.2	1.6	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.3	-1.1	-0.7	-0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.5	-0.0	0.5
Serious illness, injury or assault to yourself	0.6	0.7	1.7	1.3	0.5	-0.3
High blood pressure	0.4	1.2	2.6	0.4	1.6	0.9
Hayfever, allergic rhinitis or eczema	1.0	2.2	5.4	-0.7	0.9	2.3
Multivitamins +/- minerals	0.1	0.1	0.3	-0.6	0.2	0.2
Stomach or abdominal pain in last month	0.4	0.5	1.4	1.2	-0.5	0.2
Supplements: Glucosamine	0.8	1.0	2.0	0.1	-1.0	1.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.3	-0.5	2.1	0.9
Medication: Atenolol	1.0	1.2	2.1	1.0	1.5	0.7
Medication: Levothyroxine sodium	1.3	2.2	6.0	-2.4	-0.9	0.1
Sitting height	0.8	5.9	14.6	-1.2	-3.8	1.2
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	-0.1	0.0	0.7
High blood pressure (mother)	0.2	0.2	0.6	0.0	0.3	0.8
Body mass index (BMI)	0.5	2.2	6.4	-0.4	-2.5	-0.3
Impedance of leg (left)	0.8	4.1	8.6	1.4	2.9	-1.3
Leg predicted mass (left)	1.4	7.2	19.9	-1.2	-4.5	0.2
Trunk fat mass	0.6	2.7	7.1	-0.7	-2.7	-0.8
Waist circumference	0.3	1.0	1.5	-1.1	-1.2	-0.6
Number of incorrect matches in round	0.1	0.2	0.4	-0.5	0.2	0.7
Past tobacco smoking	0.6	1.1	1.9	1.1	1.4	0.5
Alcohol usually taken with meals	0.1	0.1	0.4	0.2	0.6	0.1
Nervous feelings	0.6	1.2	3.4	1.8	-0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	1.3	-0.1	-0.3
Hearing difficulty/problems with background noise	1.2	1.8	2.5	1.6	1.1	1.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.1	0.1	0.4
Had menopause	1.1	1.3	3.3	0.7	0.5	-1.8
Had other major operations	0.6	0.8	2.2	1.5	-0.3	-0.2
Forced vital capacity (FVC)	1.2	4.7	9.3	-1.8	-3.0	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	0.7	0.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.1	-0.4	-1.8	0.1
Qualifications: None of the above	0.1	0.2	0.3	0.3	0.1	-0.6
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.2	-0.3	0.3
Mouth/teeth dental problems	0.6	0.9	2.0	-0.7	1.4	-0.5
Heart attack	0.0	0.0	0.1	-0.1	-0.2	-0.1
Allergy	0.4	1.0	1.6	0.7	-1.0	-1.3
Pain all over the body in last month	0.8	0.9	1.5	1.2	-0.9	-0.6
Diabetes (self-reported)	1.4	2.1	5.0	-0.7	0.9	-2.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.3	-0.5	0.7	1.5
Medication: Ramipril	0.1	0.2	0.3	0.5	-0.2	0.5
Medication: Simvastatin	0.4	0.6	1.3	-0.4	1.2	-0.6
Fluid intelligence score	1.2	2.5	6.0	-2.4	-0.1	1.2
Illnesses of siblings	0.2	0.2	0.4	0.2	-0.7	-0.5
Neuroticism score	0.6	1.2	3.4	1.8	-0.4	-0.0
Weight	1.3	6.5	19.1	-0.7	-4.4	-0.0
Impedance of arm (right)	0.5	2.2	6.5	-0.3	2.5	0.0
Arm fat percentage (right)	0.4	1.5	3.7	-0.8	-1.9	-0.3
Trunk fat-free mass	1.6	9.2	25.4	-1.4	-5.0	0.5
Hip circumference	1.0	4.2	12.2	-0.3	-3.5	0.4
Time employed in main current job	0.3	0.4	0.5	0.7	0.6	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	1.0	0.2	-0.4	-1.0
Father’s age at death	0.6	0.8	1.9	1.4	-0.4	0.5
Worrier / anxious feelings	2.2	4.1	10.2	3.2	0.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	5.0	2.2	-0.5	-0.7
Falls in the last year	0.8	1.1	2.0	1.4	-1.1	-0.1
Hair/balding pattern: Pattern 3	0.4	0.5	0.9	-0.1	1.0	0.8
Number of live births	1.4	2.0	5.2	2.3	0.9	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.1	-1.1	-1.8	1.3
Pulse rate	0.2	0.3	0.4	0.6	0.4	0.6
Happiness	2.0	2.4	6.0	1.0	-2.5	-0.5
Noisy workplace	1.1	1.4	2.4	1.5	-0.5	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.7	-1.6	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	6.9	-0.2	1.1	2.6
Mouth/teeth dental problems: Dentures	1.4	2.4	3.5	1.9	-1.2	1.5
Asthma	1.0	1.9	3.0	-1.6	1.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.0	0.1	-0.1	-1.4
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.2	0.7	0.5
Depression (self-reported)	1.6	1.9	4.9	-0.6	-0.6	-2.2
Medication: Lansoprazole	1.0	1.1	2.0	0.6	1.0	-1.4
Prospective memory result	2.5	3.0	4.7	0.0	-2.2	-2.1
Lung cancer (father)	0.5	0.6	1.7	-0.2	1.3	0.3
Illnesses of mother	0.7	0.9	1.9	0.7	-0.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.9	-1.1	-2.0	0.5
Pulse wave Arterial Stiffness index	0.8	0.9	1.8	1.3	0.6	0.8
Impedance of arm (left)	0.4	1.9	5.5	0.0	2.4	-0.2
Arm fat mass (right)	0.7	3.0	8.6	-0.6	-2.9	-0.3
Trunk predicted mass	1.6	8.9	24.4	-1.4	-4.9	0.6
Standing height	0.6	6.4	17.8	-1.1	-4.2	0.6
Length of working week for main job	1.7	1.9	3.1	1.8	-0.4	-1.6
Exposure to tobacco smoke at home	1.3	1.4	1.8	1.0	-1.3	-1.2
Breastfed as a baby	0.3	0.3	0.5	-0.7	0.4	0.6
Tense / ‘highly strung’	0.3	0.5	1.0	0.1	-0.6	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	6.5	-1.5	-0.0	-2.5
Hair/balding pattern: Pattern 4	2.0	4.7	10.3	0.0	2.0	3.2
Birth weight of first child	0.4	0.8	1.6	1.3	0.4	-0.7
Peak expiratory flow (PEF)	0.6	1.4	2.7	-1.6	-0.2	1.2
Pulse wave reflection index	1.7	2.2	3.1	1.8	1.5	1.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.1	1.8	-0.1	-1.5
Loud music exposure frequency	0.4	0.4	0.6	0.6	-0.5	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	-0.0	-0.7	1.1
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.1	-1.8	-1.2	-0.4
Blood clot in the leg (DVT)	0.6	0.7	1.1	0.4	-1.1	0.9
Medication: Paracetamol	1.1	1.7	2.9	1.4	1.7	-0.7
Headache pain in last month	0.0	0.0	0.1	-0.3	-0.2	0.0
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.6	0.2	-1.3	-1.0
Glaucoma (self-reported)	0.4	0.5	1.2	1.1	-0.2	-0.5
Gout (self-reported)	0.2	0.2	0.6	0.8	0.1	0.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.8	-2.2	-1.6	-0.3
Medication: Amlodipine	1.2	1.7	4.1	0.8	2.0	0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.4	-0.6	0.2	1.2
Birth weight	0.2	0.4	0.6	0.8	-0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	-0.4	0.5	-0.9
High blood pressure (siblings)	0.2	0.3	0.5	0.6	0.7	-0.4
Forced vital capacity (FVC), Best measure	1.1	4.1	9.9	-1.5	-3.1	0.5
Body fat percentage	0.3	1.3	2.8	-0.3	-1.7	-1.0
Leg fat percentage (right)	0.4	1.5	4.0	-0.1	-2.0	-0.8
Arm fat-free mass (right)	1.3	6.6	19.0	-0.8	-4.4	-0.3
Exposure to tobacco smoke outside home	1.6	2.2	4.5	2.1	1.0	-1.1
Comparative body size at age 10	0.9	2.4	6.6	2.6	0.0	0.7
Number of full brothers	0.6	0.8	1.8	-0.7	-0.3	1.4
Worry too long after embarrassment	0.7	1.2	2.1	1.4	0.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.1	-0.5	-1.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	0.5	0.6	0.2
Number of children fathered	0.1	0.1	0.1	0.3	0.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	-1.2	-0.4	-0.9
Age at first live birth	0.3	0.5	1.5	0.2	1.2	-0.1
Pulse wave peak to peak time	1.0	1.1	1.7	-1.3	-1.0	-0.8
Health satisfaction	0.6	0.7	2.0	1.4	-0.3	0.2
Shortness of breath walking on level ground	0.4	0.5	1.4	1.2	-0.2	0.1
Qualifications: College or University degree	0.9	2.9	6.6	-2.6	-1.5	-0.3
Eye problems/disorders: None of the above	0.5	0.6	0.9	-0.3	1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.2	0.3	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.0	0.4	-1.1
Medication for pain relief, constipation, heartburn	1.3	2.1	3.0	-1.5	-1.7	1.1
Neck or shoulder pain in last month	0.1	0.1	0.2	0.3	0.0	0.4
Medication: Blood pressure	1.2	2.0	4.7	0.5	2.2	1.1
Angina (self-reported)	0.2	0.3	0.4	0.7	0.5	0.5
Migraine (self-reported)	2.0	2.5	5.4	-2.3	-0.9	1.1
Medication: Ibuprofen	1.7	2.0	6.0	-0.1	-0.3	-2.4
Medication: Allopurinol	0.4	0.5	0.7	0.6	-0.8	0.7
Medication: Omeprazole	1.9	2.3	6.2	2.5	0.4	0.8
Medication: Seretide 50 evohaler	1.3	1.5	3.9	-2.0	0.4	-0.6
Mean time to correctly identify matches	1.5	2.9	4.9	0.3	1.9	-2.2
Heart disease (mother)	1.1	1.3	2.4	-1.6	-0.7	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-1.0	-0.5	-0.7
Whole body fat mass	0.7	2.9	7.9	-0.5	-2.8	-0.8
Leg fat mass (right)	0.8	3.1	8.8	-0.1	-3.0	-0.7
Arm predicted mass (right)	1.1	5.7	16.9	-0.4	-4.1	-0.2
Pulse rate, automated reading	0.3	1.1	1.9	-0.1	1.1	-1.4
Alcohol intake frequency.	1.5	3.5	9.1	0.7	3.0	1.0
Comparative height size at age 10	1.2	6.4	18.5	0.7	-4.3	-0.5
Number of full sisters	0.5	0.6	1.4	-0.3	1.2	-0.6
Suffer from ‘nerves’	0.2	0.3	0.5	0.7	0.4	0.4
Overall health rating	1.0	2.1	3.9	2.0	-0.5	-1.5
Chest pain or discomfort	1.1	1.6	2.2	1.5	1.1	1.2
Had major operations	0.1	0.1	0.4	-0.1	-0.0	-0.6
Age at last live birth	0.8	1.1	1.6	1.1	1.3	0.6
Family relationship satisfaction	0.5	0.6	1.0	0.9	-1.0	-0.2
Leg pain on walking	1.9	2.3	4.7	2.2	-1.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	6.3	1.6	2.5	-1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	-0.5	0.1	-1.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.5	-0.0	0.2
Medication: Aspirin	0.7	0.9	2.0	-0.7	1.4	-0.5
Supplements: Vitamin C	1.5	1.8	3.4	-1.8	-0.7	1.2
Knee pain experienced in last month	0.9	1.4	3.3	-0.9	0.1	1.8
Hypertension (Self-reported)	0.7	2.0	3.8	1.1	1.9	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.6	1.1	0.2
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.4	1.0	-0.3
Illnesses of siblings: Diabetes	0.6	0.7	1.2	-1.1	0.6	0.8
Smoking status: Previous	0.6	1.0	1.5	-0.8	-1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	6.0	-2.4	-2.0	0.9
Whole body fat-free mass	1.4	8.2	22.7	-1.3	-4.8	0.3
Leg fat-free mass (right)	1.4	7.2	19.8	-1.3	-4.5	0.4
Arm fat percentage (left)	0.3	1.3	3.2	-0.7	-1.8	-0.5
Average weekly red wine intake	0.1	0.1	0.2	-0.2	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	-0.0	0.5	-1.0
Mood swings	0.5	0.9	1.8	1.3	-0.9	-0.4
Loneliness, isolation	0.4	0.5	1.3	0.5	-1.1	0.0
Long-standing illness, disability or infirmity	0.5	0.8	1.8	0.7	1.4	-0.3
Ever had bowel cancer screening	0.4	0.5	0.8	0.4	-0.7	0.9
Diabetes diagnosed by doctor	0.8	1.4	2.9	-0.6	0.9	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	0.9	-1.0	0.8	0.6
Friendships satisfaction	0.2	0.2	0.4	0.6	-0.4	0.3
Qualifications: nursing, teaching	1.8	2.8	5.6	-2.4	-0.3	-1.7
Commuting to job workplace: Walk	1.0	1.1	2.1	-1.4	0.7	-0.9
Eye problems/disorders: Cataract	1.2	1.4	2.1	-1.5	-0.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.1	-0.9	-1.8	0.4
Medication for cholesterol	0.1	0.2	0.4	0.6	-0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	-0.3	-0.1	-1.4
Back pain experienced in last month	0.6	0.9	1.5	1.2	-0.8	-0.6
Mineral and other dietary supplements	0.6	0.9	1.6	-0.8	0.6	-1.2
Breast cancer (self-reported)	0.5	0.7	1.2	1.1	-0.9	0.0
Asthma (self-reported)	0.8	1.7	2.9	-1.4	1.7	0.3
Osteoporosis (self-reported)	0.4	0.5	1.4	-1.2	0.0	0.1
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.7	-0.1	0.2
Medication: Aspirin	0.5	0.6	1.2	-0.5	1.1	-0.5
Medication: Gliclazide	0.2	0.2	0.4	-0.3	-0.4	-0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.6	-0.9	-0.2
Smoking status: Current	0.3	0.5	0.8	-0.9	0.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.6	-0.1	-0.1
Whole body water mass	1.4	8.2	23.1	-1.2	-4.8	0.2
Leg predicted mass (right)	1.3	7.2	19.5	-1.4	-4.4	0.4
Arm fat mass (left)	0.6	2.6	7.2	-0.7	-2.7	-0.4
Number of self-reported non-cancer illnesses	0.8	1.4	3.6	-1.9	0.4	0.7
Average weekly champagne plus white wine intake	1.1	1.6	2.3	-0.5	-1.5	-1.5
Miserableness	0.5	0.9	1.1	0.9	-1.1	-0.9
Guilty feelings	0.6	0.9	1.4	-1.0	-1.2	-0.4
Wears glasses or contact lenses	2.2	2.5	3.8	1.8	0.6	1.9
Ever taken oral contraceptive pill	2.4	2.6	3.9	-1.7	1.1	-2.0
Hearing aid user	1.0	1.1	2.1	0.9	0.6	1.5
Mother’s age at death	0.9	1.1	2.4	-0.4	-1.6	-0.9
Financial situation satisfaction	1.9	2.4	7.1	2.7	-0.1	0.2
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.7	-0.9	0.1	-1.6
Commuting to job workplace: Public transport	0.3	0.4	0.9	-1.0	-0.4	0.3
Eye problems/disorders: Glaucoma	1.7	2.0	3.1	1.8	-0.9	-1.4
Medication: Blood pressure	0.4	0.7	1.2	0.9	0.3	1.1
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.0	1.7	0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.7	0.7	-0.6	1.3
High cholesterol (Self-reported)	0.6	1.1	1.9	-1.4	1.2	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	-0.4	0.4
Medication: Paracetamol	1.3	2.0	3.0	1.7	1.2	-1.3
Medication: Lisinopril	0.3	0.4	0.8	-0.9	-0.1	0.6
Medication: Atorvastatin	0.2	0.3	0.4	-0.6	-0.2	0.6
Illnesses of father: High blood pressure	1.6	2.0	3.2	1.8	1.5	-0.8
Alcohol drinker status: Never	2.2	2.6	4.5	-0.0	1.8	-2.1
Ever smoked	0.3	0.6	1.3	-0.6	-1.1	-0.2
Basal metabolic rate	1.5	8.5	23.9	-1.3	-4.9	0.2
Leg fat percentage (left)	0.4	1.3	3.1	-0.2	-1.7	-0.9
Arm fat-free mass (left)	1.2	6.0	17.6	-0.7	-4.2	0.0
Number of operations (self-reported)	1.1	1.6	2.3	1.5	-1.2	1.0
Average weekly beer plus cider intake	0.2	0.3	0.4	0.6	-0.3	-0.6
Irritability	0.3	0.5	1.3	0.2	-0.1	1.1
Risk taking	1.2	1.7	2.4	-1.3	-1.5	-1.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.3	-0.4	-1.8	-0.0
Fractured/broken bones in last 5 years	0.9	1.2	2.6	0.5	-1.6	-0.9
Age started oral contraceptive pill	1.0	1.3	3.6	0.2	1.9	0.3
Diastolic blood pressure, automated reading	0.8	2.5	5.7	-0.8	2.4	-1.1
Ever depressed for a whole week	0.3	0.4	0.9	0.3	-0.5	0.9
Unable to work because of sickness or disability	0.6	0.8	1.3	1.1	-1.1	-0.1
Commuting to job workplace: Cycle	1.1	1.3	1.6	-1.1	-1.3	1.0
Myopia	0.8	1.2	3.3	-1.8	-0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.5	-0.2	-1.2	-1.2
Cholesterol lowering medication	0.2	0.3	0.6	-0.3	0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.4	2.1	0.5	1.3
Pain experienced in last month	0.7	1.2	3.5	-0.2	0.3	-1.9
Supplements: Calcium	0.6	0.7	1.7	-1.3	-0.6	-0.2
Basal cell carcinoma (self-reported)	1.5	1.7	3.5	-0.3	1.9	1.3
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.2	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.2	0.2	-1.1	0.9
Heart disease (siblings)	0.8	0.9	1.6	1.3	1.0	-0.5
Alcohol drinker status: Previous	0.5	0.6	1.8	-0.3	1.3	-0.2
Pack years of smoking	0.3	0.5	0.8	0.9	-0.1	0.8
Impedance of whole body	0.7	3.5	9.1	0.8	3.0	-0.8
Leg fat mass (left)	0.7	2.6	7.2	-0.2	-2.7	-0.8
Arm predicted mass (left)	1.3	6.8	19.8	-0.7	-4.5	-0.1