TWAS hub - UBLCP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.5750	0.0900	2.7e-05	-0.009	NA	0.121	NA	0.084	7.3e-01	NA	3.1e-04	NA	2.5e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.1364	0.0390	2.8e-06	0.064	0.043	0.029	0.050	0.048	1.2e-08	3.1e-06	1.0e-04	4.4e-07	8.2e-07
3	YFS	Blood	0.0702	0.0188	1.6e-08	0.027	0.028	0.021	0.053	0.022	2.6e-09	1.5e-09	1.4e-07	6.0e-17	5.2e-08
4	TCGA	Lung Adenocarcinoma	0.0404	0.0217	1.5e-03	0.034	0.019	0.026	NA	0.029	6.9e-05	2.3e-03	4.8e-04	NA	2.1e-04
5	TCGA	Pancreatic Adenocarcinoma	0.0870	0.0540	6.1e-03	0.038	0.034	0.023	NA	0.032	1.0e-02	1.4e-02	3.7e-02	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Primary Biliary Cirrhosis	4.7	6.7	18.9	-0.3	-1.2	-3.4	-4.3	1.2
Crohns Disease (2017)	3.6	8.0	18.8	0.7	-1.6	2.9	4.3	-3.1
Irritable Bowel Disease (IBD)	3.6	8.5	19.7	1.1	-1.1	2.9	3.5	-4.4
Crohns Disease (2012)	3.3	5.3	11.8	-0.1	-1.4	2.3	3.4	-2.7
Medication: Co-codamol	3.3	3.8	8.7	-3.0	0.7	-1.4	-0.6	2.8
Mouth/teeth dental problems: Mouth ulcers	3.2	5.0	19.2	-1.0	-0.8	1.7	1.3	-4.4
Ovarian Cancer	2.8	3.8	11.4	1.0	0.9	-1.0	-2.1	-3.4
Blood Platelet Count	2.6	30.2	94.7	0.3	2.3	-6.3	-9.7	-3.4
Medication: Atenolol	2.5	3.1	5.7	0.8	2.2	1.1	1.7	2.4
Glaucoma (self-reported)	2.3	2.7	8.2	-1.2	1.6	0.4	1.2	2.9
Illnesses of father: None of the above (group 1)	2.2	2.7	5.7	2.4	1.3	-0.8	-1.8	-1.5
Angina	2.1	2.7	5.3	-2.1	1.4	-1.1	-1.0	2.3
Average weekly beer plus cider intake	2.1	3.1	7.0	1.5	-1.4	1.7	2.6	1.2
Ulcerative Colitis (UC)	2.0	3.8	13.2	1.2	0.0	1.6	1.4	-3.6
Breast Cancer	2.0	4.7	8.6	0.0	-2.8	-2.9	-2.6	0.9
Emphysema/chronic bronchitis	2.0	2.2	4.5	-0.5	2.1	1.5	1.8	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	7.5	-0.6	1.9	0.5	1.7	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	7.0	-1.1	1.3	1.3	2.6	1.0
Angina (self-reported)	1.9	2.5	5.0	-1.6	1.3	-1.2	-1.3	2.2
Average weekly red wine intake	1.9	2.9	9.1	1.4	3.0	1.1	1.3	0.7
Hypothyroidism (self reported)	1.8	4.1	6.7	-2.6	0.7	-2.1	-1.6	2.5
Lung cancer (father)	1.8	2.1	4.2	1.7	-0.5	-1.3	-2.0	-1.2
Myopia	1.8	2.6	8.1	-1.4	1.5	0.1	1.0	2.9
Schizophrenia (2018)	1.7	3.6	16.5	-0.2	-4.1	-0.7	-0.4	0.8
Ulcerative Colitis	1.7	2.5	7.6	1.6	0.1	1.3	1.0	-2.8
Supplements: Zinc	1.7	1.9	4.9	-2.2	-2.1	0.1	0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	4.7	-1.6	1.2	-2.0	-1.9	2.2
Systolic Blood Pressure	1.6	8.3	17.7	-4.2	2.0	-0.2	1.4	4.2
Time employed in main current job	1.6	1.8	5.5	0.8	0.0	-1.7	-2.3	-0.0
Medication: Lansoprazole	1.6	1.8	5.9	0.9	1.1	0.1	1.0	2.4
Chronic bronchitis/emphysema (mother)	1.6	1.8	4.8	-2.2	0.7	0.6	1.4	1.2
Schizophrenia (2014)	1.5	3.4	14.6	0.8	-3.8	0.1	0.7	1.1
Ever had hysterectomy (womb removed)	1.5	1.7	4.8	0.0	0.8	1.3	2.2	1.1
Past tobacco smoking	1.5	2.8	8.1	-2.8	0.6	-1.5	-1.7	0.6
Smoking status: Previous	1.5	2.3	7.1	2.7	-0.3	1.3	1.5	-0.2
Major Depression (MDD)	1.4	1.7	6.5	-2.6	-0.2	-0.6	-1.1	0.2
Fasting Glucose	1.4	1.7	3.8	-0.1	1.6	1.4	0.4	-2.0
Average weekly spirits intake	1.4	1.7	8.0	-0.1	2.8	0.0	0.1	0.6
Illnesses of siblings	1.4	2.0	4.5	0.7	-2.1	-1.1	-1.8	-0.7
Mouth/teeth dental problems: Loose teeth	1.4	1.6	3.7	-1.5	0.1	1.4	1.9	-0.5
Mean time to correctly identify matches	1.4	2.6	11.2	1.0	3.4	0.3	-0.1	-0.8
Medication: Blood pressure	1.4	2.7	11.7	-0.9	-0.2	-0.2	0.9	3.4
Medication: Bendroflumethiazide	1.4	2.2	6.3	-0.2	-0.7	1.3	2.5	1.5
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.9	2.2	1.4	-0.5	-0.9	0.1
Rheumatoid Arthritis	1.3	1.8	3.6	-0.7	-0.2	-1.9	-1.5	1.6
Trunk fat percentage	1.3	5.3	13.2	0.6	3.6	1.6	2.6	1.9
Medication: Levothyroxine sodium	1.3	2.2	6.5	-1.5	0.5	-1.1	-1.0	2.6
Arm fat percentage (right)	1.3	5.0	16.0	0.7	4.0	0.8	1.7	2.2
Prospective memory result	1.3	1.6	4.1	-0.2	1.5	-1.1	-2.0	-0.1
Hair/balding pattern: Pattern 4	1.3	3.1	8.3	2.2	2.9	1.4	-0.2	-0.6
Body fat percentage	1.3	5.1	13.0	0.4	3.6	1.2	2.3	2.3
Medication: Blood pressure	1.3	2.4	6.6	-0.6	2.6	0.6	1.2	1.8
Family relationship satisfaction	1.3	1.6	4.9	0.9	2.2	0.3	0.3	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.4	1.6	-0.0	-1.4	-1.8	0.0
Medication: Aspirin	1.3	1.7	4.2	-0.2	2.0	-0.0	0.3	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.6	-0.3	1.6	1.0	1.4	1.3
Arm fat percentage (left)	1.3	5.2	14.1	0.5	3.8	1.0	2.0	2.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.0	1.2	-1.7	-1.0	-1.3	-0.0
Medication for cholesterol	1.3	1.9	5.1	2.0	-0.4	0.8	0.1	-2.3
Medication: Aspirin	1.3	1.7	4.8	-0.6	1.8	0.1	0.5	2.2
Ever smoked	1.3	2.2	5.9	2.4	0.2	1.4	1.3	-1.3
Risk taking	1.3	1.9	5.7	-0.7	-2.4	-0.9	-1.1	-1.2
Bipolar Disorder or Schizophrenia	1.2	2.9	13.0	0.3	-3.6	-0.4	0.2	1.1
Prostate Cancer	1.2	1.6	2.8	1.2	-1.7	-1.4	-1.0	-0.9
Average weekly fortified wine intake	1.2	1.4	2.5	0.7	1.6	1.3	1.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.9	-0.7	0.2	-1.8	-2.0	0.3
Heart disease (mother)	1.2	1.5	3.3	0.9	1.0	-1.2	-0.9	1.8
Had major operations	1.2	1.5	3.1	-1.3	-0.2	1.4	1.8	-0.8
Loneliness, isolation	1.2	1.6	3.9	-0.5	-0.9	1.5	2.0	-0.9
Medication: Gliclazide	1.2	1.4	2.8	-0.1	1.4	1.3	1.7	-0.7
Leg fat percentage (left)	1.2	4.5	12.2	0.0	3.5	0.8	2.0	2.4
Depression (Nagel 2018)	1.1	1.6	3.5	-0.8	0.8	-1.7	-1.9	0.6
Alzheimer’s Disease (in mother)	1.1	1.3	3.8	-0.8	0.0	1.3	1.9	0.6
Body Mass Index (BMI) (2010)	1.1	1.6	6.5	1.0	2.5	-0.1	-0.4	-0.3
Mean Putamen Volume	1.1	1.2	3.7	0.8	-0.5	-1.3	-1.9	0.0
Cardiovascular Disease	1.1	3.8	10.6	-2.7	0.5	-0.9	0.0	3.2
Relative age of first facial hair	1.1	2.3	9.6	3.1	1.1	0.7	0.3	0.5
Systolic blood pressure, automated reading	1.1	3.1	7.9	-2.0	1.7	-0.6	0.6	2.8
Pack years adult smoking proportion	1.1	1.7	3.1	-1.8	-1.4	-0.7	-0.9	-1.5
Medication: Ramipril	1.1	1.4	4.2	0.1	1.3	0.3	1.0	2.0
Medication: Simvastatin	1.1	1.6	2.6	-0.1	1.4	0.9	1.6	1.6
Hair/balding pattern: Pattern 3	1.1	1.7	6.0	2.4	1.2	0.4	0.0	-0.9
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.6	0.2	0.2	1.4	1.9	1.0
Leg fat percentage (right)	1.1	4.1	10.4	-0.1	3.2	0.8	2.1	2.2
Age at first live birth	1.1	2.0	4.5	0.7	2.1	1.5	1.6	0.5
Health satisfaction	1.1	1.4	6.7	0.3	2.6	0.2	-0.1	0.4
Hypertension (Self-reported)	1.1	2.9	9.9	-0.8	1.9	-0.6	0.2	3.2
Illnesses of siblings: Diabetes	1.1	1.3	3.0	-0.6	1.7	0.8	1.4	0.7
Guilty feelings	1.1	1.6	3.8	0.2	1.9	1.1	1.6	0.6
Wears glasses or contact lenses	1.1	1.2	3.3	0.1	1.8	-0.9	-1.4	-0.0
Reaction Time	1.0	1.8	5.0	1.0	2.2	0.7	0.2	-1.6
Bipolar Disorder (2011)	1.0	0.9	1.9	-0.8	-1.4	-0.5	-0.7	-1.1
Triglycerides	1.0	1.6	2.9	1.1	0.8	1.7	1.7	-0.7
Number of treatments/medications taken	1.0	1.7	4.1	-0.8	1.9	0.4	0.6	2.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.7	0.6	0.4	0.4	1.2	1.9
Trunk fat mass	1.0	4.3	10.7	0.7	3.3	1.5	2.4	1.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.4	-0.2	-0.9	-1.5	-1.6	0.9
Happiness	1.0	1.2	2.3	1.2	1.2	-0.8	-1.5	-0.1
Eye problems/disorders: None of the above	1.0	1.1	5.2	-0.1	-0.4	0.4	-0.2	-2.3
Back pain experienced in last month	1.0	1.4	3.3	1.8	-0.6	0.8	1.2	1.1
Mother’s age at death	1.0	1.2	2.8	-0.9	1.1	1.1	1.7	0.3
Eye problems/disorders: Glaucoma	1.0	1.2	4.1	-1.1	0.6	-0.1	0.4	2.0
Illnesses of father: High blood pressure	1.0	1.3	3.1	-1.8	-0.7	0.8	1.3	0.6
Alzheimer’s Disease (including proxy)	0.9	1.4	2.4	-1.5	-0.5	0.9	1.6	1.1
LDL Cholesterol	0.9	1.4	3.8	1.3	1.9	0.3	0.7	-1.1
BMI	0.9	5.3	11.8	1.1	3.2	0.2	1.9	3.4
Severe depression (siblings)	0.9	1.1	2.7	-0.4	-0.1	-1.2	-1.0	1.7
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.0	1.4	1.4	-0.4	-0.6	1.2
Chronic bronchitis/emphysema (father)	0.9	1.0	3.3	-1.8	1.2	0.4	0.4	-0.3
Body mass index (BMI)	0.9	3.8	9.1	0.9	3.0	0.7	1.8	2.4
Falls in the last year	0.9	1.2	4.1	-0.9	-1.0	-0.5	0.0	2.0
Medication: Cholesterol lowering	0.9	1.4	3.9	-0.8	2.0	0.7	0.7	1.1
Breastfed as a baby	0.9	1.1	2.4	0.5	-1.5	-1.0	-1.3	0.3
Headache pain in last month	0.9	1.6	4.0	1.7	-0.2	0.7	-0.6	-2.0
High blood pressure (siblings)	0.9	1.3	2.3	-0.7	1.1	1.0	1.5	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.1	1.0	1.4	0.9	1.1	0.2
Medication: Seretide 50 evohaler	0.9	1.0	2.7	0.0	-1.1	1.1	1.6	-0.3
Whole body fat mass	0.9	3.7	9.0	0.7	3.0	1.3	2.2	1.6
Age at last live birth	0.9	1.3	4.1	1.4	2.0	0.5	0.1	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.3	1.5	-0.4	0.6	0.6	-1.4
Arm fat mass (left)	0.9	3.8	9.0	1.0	3.0	1.0	2.0	1.9
Ever depressed for a whole week	0.9	1.1	4.4	0.0	-0.4	-0.8	-0.2	2.1
Commuting to job workplace: Cycle	0.9	1.1	2.9	-0.9	0.3	-1.1	-1.7	-0.9
Heart disease (siblings)	0.9	1.2	2.5	0.7	1.6	0.9	1.2	-0.8
Leg fat mass (left)	0.9	3.4	7.5	0.7	2.7	1.1	2.2	1.8
Schizophrenia vs Biploar Disorder	0.8	1.0	2.2	0.6	-1.5	-1.0	-0.6	1.1
HbA1C	0.8	0.9	3.0	-0.3	-0.3	-1.7	-1.0	-0.6
Hand grip strength (left)	0.8	2.1	6.0	1.0	-0.5	-0.6	-1.7	-2.5
Vitamin and mineral supplements	0.8	1.1	3.9	0.8	-2.0	-0.7	-0.5	0.1
Current tobacco smoking	0.8	1.3	3.7	-1.5	-1.9	-0.5	-0.4	0.1
Supplements: Glucosamine	0.8	1.0	2.3	1.1	0.1	-0.5	-1.5	-1.2
Had other major operations	0.8	0.9	1.7	1.3	0.5	0.6	0.8	1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.0	-1.2	-0.0	1.2	1.4	-1.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	6.8	2.6	-0.9	1.2	0.8	-1.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.7	-1.3	0.5	1.2	0.9	-1.1
Arm fat mass (right)	0.8	3.3	7.8	1.0	2.8	0.9	1.8	2.0
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	0.8	-1.9	-0.1	-0.3	-1.5
Birth weight	0.8	1.6	4.4	0.8	1.6	0.5	-0.5	-2.1
Pulse wave peak to peak time	0.8	1.0	3.7	1.0	-0.5	0.2	-0.1	-1.9
Shortness of breath walking on level ground	0.8	0.9	1.3	-1.2	1.1	-0.9	-1.0	-0.1
Leg fat mass (right)	0.8	3.1	6.7	0.6	2.6	1.0	2.1	1.6
Chest pain or discomfort	0.8	1.1	2.6	-0.9	1.5	-0.2	-0.2	1.6
Leg pain on walking	0.8	1.1	4.1	-2.0	-0.1	-0.3	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	0.8	-0.7	1.0	1.0	-1.3
Smoking status: Current	0.8	1.3	4.8	-1.1	-2.2	-0.6	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	7.4	2.7	-0.2	0.6	0.6	0.5
Medication: Lisinopril	0.8	1.1	3.4	0.5	1.8	0.6	1.1	0.5
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.9	0.3	-2.1	0.8	0.4	-2.4
Cholesterol lowering medication	0.8	1.2	3.9	-1.2	0.2	-0.2	0.8	2.0
Pack years of smoking	0.8	1.1	2.5	-1.6	-0.7	-0.7	-1.0	-1.1
Lupus	0.7	1.0	2.5	-0.1	-1.6	-0.5	-0.6	1.4
Waist Hip Ratio (WHR)	0.7	3.0	6.0	1.1	-0.9	-1.0	-2.5	-2.4
Medication: Metformin	0.7	1.0	3.7	-1.9	-0.2	0.0	-0.6	-0.9
Townsend deprivation index at recruitment	0.7	1.0	3.8	-0.2	0.5	0.3	1.0	2.0
Taking other prescription medications	0.7	1.0	3.1	-1.0	0.9	-0.2	0.5	1.8
Serious illness, injury or assault to yourself	0.7	0.8	2.2	-0.1	0.4	1.2	1.5	0.7
High blood pressure	0.7	2.1	5.5	-0.8	1.8	-0.9	-0.3	2.4
Asthma	0.7	1.4	4.4	-0.8	0.7	1.0	2.1	0.7
Pulse wave Arterial Stiffness index	0.7	0.8	3.0	-1.0	0.2	-0.2	0.0	1.7
Exposure to tobacco smoke at home	0.7	0.7	1.9	1.4	0.8	0.1	-0.6	-0.9
Peak expiratory flow (PEF)	0.7	1.6	2.6	1.4	0.8	1.1	1.3	-1.6
Loud music exposure frequency	0.7	0.8	1.3	0.4	-1.1	-0.9	-1.1	0.5
Exposure to tobacco smoke outside home	0.7	0.9	1.8	-0.1	0.5	1.1	1.1	-1.3
Worry too long after embarrassment	0.7	1.1	2.5	-0.7	-0.3	1.2	1.6	1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	2.4	-0.5	-1.2	-1.4	-1.5	0.4
Medication: Allopurinol	0.7	0.9	1.7	-1.0	0.7	1.3	1.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.4	-1.2	1.1	0.7	1.2	-0.3
Number of full sisters	0.7	0.8	1.7	-1.3	-0.7	-0.9	-0.2	1.0
Overall health rating	0.7	1.4	5.1	0.7	2.3	-0.0	0.1	1.3
Commuting to job workplace: Car/motor vehicle	0.7	0.7	1.7	-0.2	-0.9	-0.9	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.4	-1.1	-1.5	0.8	1.2	-1.1
Friendships satisfaction	0.7	0.9	3.2	-1.0	1.8	-0.3	-0.3	-0.2
Osteoporosis (self-reported)	0.7	0.8	2.2	-0.5	-0.2	-0.7	-1.1	1.5
High cholesterol (Self-reported)	0.7	1.2	1.8	-1.2	1.0	-0.9	-0.8	1.3
Supplements: Calcium	0.7	0.7	3.4	0.3	-0.4	-0.1	-0.0	1.9
Alzheimer’s Disease (in father)	0.6	0.6	1.8	-0.9	-1.4	-0.4	-0.3	-0.4
Age at First Birth	0.6	0.9	3.1	1.8	-0.7	-0.1	-0.1	-1.0
Coronary Artery Disease (CAD)	0.6	0.7	2.4	-0.3	-1.6	-0.6	-0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	-0.8	0.7	0.7	1.1	0.6
Diabetes (mother)	0.6	0.8	2.9	-1.7	0.8	-0.1	0.4	0.5
Relative age voice broke	0.6	0.9	3.5	1.9	-0.4	0.5	0.3	0.8
Multivitamins +/- minerals	0.6	0.8	1.9	-0.1	0.7	1.3	1.4	0.0
Number of incorrect matches in round	0.6	0.9	2.7	0.4	0.9	-0.6	-1.7	-0.9
Forced vital capacity (FVC)	0.6	2.2	3.8	1.8	-1.9	0.8	-0.1	-1.9
Mouth/teeth dental problems	0.6	0.9	3.9	0.8	0.1	0.1	0.1	2.0
Diabetes (self-reported)	0.6	0.9	2.5	-1.3	1.6	0.1	0.1	-0.5
Hip circumference	0.6	2.4	5.5	1.0	2.4	1.1	1.7	1.1
Illnesses of mother	0.6	0.8	1.4	0.9	-1.2	0.0	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	7.7	2.8	-0.6	0.7	0.3	-1.1
Pulse wave reflection index	0.6	0.8	3.0	-1.7	0.6	0.1	0.5	0.5
Number of children fathered	0.6	0.7	1.3	0.7	-0.4	-1.1	-1.0	0.9
Comparative height size at age 10	0.6	3.1	13.2	-0.6	-1.2	0.4	-0.7	-3.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.5	-1.6	-0.8	-0.2	-0.3	0.3
Asthma (self-reported)	0.6	1.1	3.5	-0.8	0.6	0.9	1.9	0.3
Osteoarthritis (self-reported)	0.6	0.8	1.6	0.4	0.7	-1.1	-1.2	0.5
Age started oral contraceptive pill	0.6	0.7	1.6	-0.5	0.7	1.1	1.3	0.1
Pain experienced in last month	0.6	1.0	3.9	-2.0	0.6	-0.1	0.6	0.7
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	-1.2	1.3	-0.3	-0.4	0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.1	-0.0	1.1	0.6	-0.6	-0.9
Blood Red Count	0.5	4.7	22.2	-4.7	0.7	0.4	0.7	0.3
Heel T-Score	0.5	3.8	13.0	3.6	2.3	0.5	0.3	0.1
Smoking Status	0.5	1.1	4.6	0.8	-2.2	0.0	0.2	0.6
Lung FEV1/FVC ratio	0.5	2.8	6.2	2.5	0.9	1.2	2.1	1.1
Hearing difficulty/problems: Yes	0.5	0.7	3.0	0.6	1.7	0.0	-0.2	-0.4
Age when periods started (menarche)	0.5	1.2	3.9	0.3	-2.0	0.4	0.7	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.6	1.0	-0.8	1.1	1.2	-0.9
Qualifications: CSEs or equivalent	0.5	0.6	1.5	1.2	-1.1	-0.1	-0.2	-0.6
Waist circumference	0.5	1.7	4.5	1.4	2.1	0.6	0.9	0.7
Financial difficulties in last 2 years	0.5	0.7	1.9	-0.2	-1.4	-1.0	-0.6	0.5
Allergy	0.5	1.2	3.8	0.7	-0.7	-0.8	-1.9	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.7	-0.1	0.4	-0.4	-1.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	1.0	0.3	0.8	0.3	-0.9
Birth weight of first child	0.5	0.9	2.2	0.6	0.9	1.1	0.3	-1.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.8	-0.1	-0.1	0.3	-0.3	-1.9
Forced vital capacity (FVC), Best measure	0.5	1.8	5.2	2.3	-1.5	0.4	-0.2	-1.1
Ever had bowel cancer screening	0.5	0.6	2.2	-0.0	1.5	0.1	-0.4	-0.6
Average weekly champagne plus white wine intake	0.5	0.6	2.2	-1.5	0.6	-0.3	-0.3	0.6
Ever taken oral contraceptive pill	0.5	0.6	1.4	-0.0	-1.0	0.8	0.3	-1.2
Hearing aid user	0.5	0.6	1.7	-0.0	-0.1	-1.0	-1.3	-0.3
Number of operations (self-reported)	0.5	0.8	1.7	0.2	-1.0	1.1	1.3	0.0
Fractured/broken bones in last 5 years	0.5	0.7	1.6	-1.3	-0.1	-0.3	0.4	1.2
Diastolic blood pressure, automated reading	0.5	1.6	4.1	-1.8	-0.4	-0.5	0.4	2.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	1.3	-0.2	-0.1	-0.1	1.2
Alcohol drinker status: Previous	0.5	0.5	1.9	-1.4	0.0	0.4	0.5	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.1	-0.2	2.3	-0.4	-1.1	-0.1
Worry (Nagel 2018)	0.4	0.9	2.5	-0.0	1.1	-0.9	-1.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.3	-0.2	1.2	-0.6	-1.5	-1.1
HDL Cholesterol	0.4	0.6	1.7	0.3	-0.8	-0.6	-0.3	1.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-0.7	0.7	-0.7	-0.0	1.0
Diabetes (father)	0.4	0.5	1.2	1.0	-1.1	-0.2	-0.2	-0.0
Hand grip strength (right)	0.4	1.2	3.8	1.1	0.3	-0.1	-0.8	-2.0
Maternal smoking around birth	0.4	0.6	2.1	-0.6	-0.6	-0.2	-0.3	-1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.4	-0.7	-0.7	0.1	0.2	1.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.8	-0.2	0.0	0.7	1.7	1.2
High blood pressure (mother)	0.4	0.6	2.7	0.2	1.6	-0.1	0.3	0.4
Alcohol usually taken with meals	0.4	0.6	2.7	-1.7	-0.2	0.2	0.1	-0.5
Hearing difficulty/problems with background noise	0.4	0.7	1.3	0.7	1.1	-0.2	-0.6	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.3	-0.8	0.7	0.2	-1.2
Fluid intelligence score	0.4	0.8	2.5	-0.3	0.8	0.1	-0.9	-1.6
Weight	0.4	2.1	3.9	0.9	1.9	1.2	2.0	0.9
Father’s age at death	0.4	0.6	1.7	0.2	-0.6	0.7	0.5	-1.3
Mouth/teeth dental problems: Dentures	0.4	0.6	2.2	-0.2	0.8	-0.5	-0.1	1.5
Tense / ‘highly strung’	0.4	0.7	1.3	0.6	1.1	0.3	0.8	1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.2	-1.1	-0.4	-0.3	-0.5	-1.1
Blood clot in the leg (DVT)	0.4	0.6	1.3	1.1	0.1	-0.9	-0.8	-0.2
Qualifications: College or University degree	0.4	1.3	2.9	0.1	1.2	1.1	1.0	-1.7
Migraine (self-reported)	0.4	0.4	1.3	0.5	1.1	0.3	-0.1	-0.7
Knee pain experienced in last month	0.4	0.6	1.3	-0.4	0.7	-1.0	-1.1	0.4
Mood swings	0.4	0.7	2.6	-0.3	-0.2	1.0	1.6	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	2.2	-0.0	1.5	-0.4	-0.3	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	1.1	0.0	0.0	-0.4	-1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	-0.5	-1.0	0.7	0.8	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	0.8	0.0	-0.9	-0.8	-0.5
Bipolar Disorder (2018)	0.3	0.4	0.6	0.7	-0.7	0.2	0.8	0.7
Height	0.3	5.9	20.7	0.1	-4.5	0.8	-0.4	-2.8
Respiratory disease	0.3	0.6	1.6	-0.2	1.3	0.1	0.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-0.9	0.5	-0.2	-0.2	1.1
Fed-up feelings	0.3	0.6	1.7	1.3	0.2	0.2	0.5	-0.8
Qualifications: None of the above	0.3	0.6	1.3	-1.2	0.2	-0.7	-0.6	0.9
Heart attack	0.3	0.4	1.1	1.0	-0.1	-0.0	0.1	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.0	0.4	1.4	-0.1	0.5	0.2
Standing height	0.3	3.3	10.0	0.0	-2.3	1.0	0.2	-3.2
Length of working week for main job	0.3	0.3	0.8	-0.4	-0.7	-0.1	-0.1	-0.9
Medication: Paracetamol	0.3	0.5	1.0	0.7	-0.8	0.5	1.0	-0.1
Medication: Amlodipine	0.3	0.4	1.1	0.2	1.0	-0.3	-0.7	-0.2
Medication: Omeprazole	0.3	0.3	1.1	1.0	0.1	0.3	-0.1	-0.7
Pulse rate, automated reading	0.3	1.0	3.0	-1.7	-1.4	0.0	0.1	0.2
Supplements: Vitamin C	0.3	0.3	1.2	0.3	-0.4	-0.1	-0.4	-1.1
Illnesses of father: Heart disease	0.3	0.4	1.4	-0.5	0.2	0.0	0.7	1.2
Leg fat-free mass (right)	0.3	1.4	3.5	1.2	0.4	1.4	1.9	0.3
Leg predicted mass (right)	0.3	1.5	3.7	1.2	0.4	1.4	1.9	0.3
Commuting to job workplace: Public transport	0.3	0.4	0.8	0.1	0.0	0.6	0.9	0.9
Medication: Atorvastatin	0.3	0.4	1.0	-0.5	0.8	0.3	0.5	1.0
Irritability	0.3	0.4	1.3	-0.8	-1.2	0.2	0.4	0.1
Unable to work because of sickness or disability	0.3	0.3	1.4	1.2	0.2	0.2	0.4	0.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.2	0.2	0.5	0.9	-1.0
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.2	1.0	-0.1	-0.4	-1.0
Neuroticism (2016)	0.2	0.3	0.7	-0.0	0.4	-0.8	-0.8	0.1
Chronotype (morning person)	0.2	0.4	1.1	-0.6	1.0	0.5	0.5	-0.5
Impedance of leg (right)	0.2	1.0	2.5	-1.1	-1.1	0.0	-0.2	-1.6
Leg fat-free mass (left)	0.2	1.2	3.2	1.0	0.4	1.3	1.8	0.4
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.2	0.5	-0.1	-0.3	-0.8
Sitting height	0.2	1.3	3.1	-0.4	-0.9	1.2	1.1	-1.8
Impedance of leg (left)	0.2	0.8	2.6	-0.8	-0.7	0.1	-0.2	-1.6
Leg predicted mass (left)	0.2	1.3	3.1	1.0	0.5	1.3	1.8	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	0.5	0.5	0.3	0.8	0.4
Had menopause	0.2	0.2	0.5	0.7	0.4	-0.3	-0.5	-0.3
Pulse rate	0.2	0.3	0.7	-0.2	-0.9	-0.3	-0.7	-0.2
Depression (self-reported)	0.2	0.2	0.7	-0.9	-0.1	-0.3	0.6	-0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.4	-0.3	-0.2	-0.6	-0.6	0.6
Gout (self-reported)	0.2	0.3	0.5	-0.1	0.7	0.6	0.1	-0.6
Arm fat-free mass (right)	0.2	0.8	2.2	0.8	-0.5	1.0	1.5	0.2
Comparative body size at age 10	0.2	0.5	0.8	0.6	0.7	-0.9	-0.4	0.9
Number of full brothers	0.2	0.2	0.7	-0.3	-0.0	-0.6	-0.8	-0.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.1	-0.5	0.6	0.8	0.4
Neck or shoulder pain in last month	0.2	0.3	0.8	0.2	-0.5	0.9	0.6	0.5
Medication: Ibuprofen	0.2	0.3	0.6	-0.8	-0.1	0.6	-0.0	-0.7
Arm predicted mass (right)	0.2	1.0	2.6	0.8	-0.6	1.1	1.6	0.1
Alcohol intake frequency.	0.2	0.5	2.6	-1.6	-0.3	0.0	0.3	-0.1
Whole body fat-free mass	0.2	0.9	1.8	1.2	-0.1	1.1	1.3	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.9	-0.4	1.0	0.4	0.1	-0.5
Qualifications: nursing, teaching	0.2	0.3	1.1	-0.2	0.1	-0.5	-0.5	1.1
Commuting to job workplace: Walk	0.2	0.2	0.5	0.5	0.0	0.6	0.7	-0.0
Mineral and other dietary supplements	0.2	0.2	0.6	-0.0	0.6	-0.2	0.2	0.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.4	0.4	0.7	-0.5	-0.5	0.4
Medication: Paracetamol	0.2	0.3	0.6	0.2	-0.6	0.5	0.8	-0.1
Basal metabolic rate	0.2	1.0	2.6	1.1	0.2	1.2	1.6	-0.0
Arm fat-free mass (left)	0.2	0.8	2.3	0.9	-0.1	1.0	1.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.8	0.9	0.2	0.5	0.4	0.4
Impedance of whole body	0.2	0.8	2.4	-1.1	-0.5	0.4	-0.1	-1.5
Arm predicted mass (left)	0.2	0.8	2.0	1.0	0.2	1.0	1.4	-0.1
Blood Eosinophil Count	0.1	1.1	3.6	-1.9	1.3	-0.1	-0.2	0.3
Blood White Count	0.1	0.9	2.6	-0.9	-0.4	-1.1	0.0	1.6
Allergy or Eczema	0.1	0.4	1.0	-0.0	-0.7	-0.0	0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.4	0.6	-0.1	-0.4	-0.5
Lung FVC	0.1	0.6	2.4	0.2	-0.3	1.5	0.8	-0.1
Tanning	0.1	0.7	2.1	1.4	0.8	-0.5	-0.2	0.7
Sensitivity / hurt feelings	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.2	-0.2	0.3	0.1	0.5
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.4	0.1	0.0	0.2	0.3
Nervous feelings	0.1	0.2	0.6	-0.8	0.4	0.1	-0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.8	-0.2	0.0	0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.6	-0.4	0.4	0.4	-0.2
Pain all over the body in last month	0.1	0.1	0.3	0.4	-0.4	-0.5	-0.3	0.1
Neuroticism score	0.1	0.2	0.7	0.0	0.0	0.6	0.8	0.4
Impedance of arm (right)	0.1	0.6	2.3	-0.6	0.3	0.5	-0.3	-1.5
Trunk fat-free mass	0.1	0.7	1.2	1.1	-0.6	0.7	0.8	-1.0
Worrier / anxious feelings	0.1	0.2	0.6	-0.7	0.3	0.3	-0.2	0.5
Noisy workplace	0.1	0.1	0.3	0.1	-0.4	0.2	0.6	0.3
Impedance of arm (left)	0.1	0.6	1.6	-0.9	-0.2	0.4	-0.4	-1.3
Trunk predicted mass	0.1	0.8	1.1	1.1	-0.5	0.8	0.8	-1.1
Suffer from ‘nerves’	0.1	0.2	0.5	-0.6	0.3	-0.2	0.2	0.7
Eye problems/disorders: Cataract	0.1	0.1	0.6	0.2	0.7	-0.1	-0.0	0.1
Breast cancer (self-reported)	0.1	0.1	0.4	-0.3	0.2	-0.1	-0.6	-0.4
Whole body water mass	0.1	0.9	1.8	1.1	-0.2	1.1	1.4	-0.3
Miserableness	0.1	0.2	0.4	-0.6	-0.3	-0.5	0.2	0.6
Financial situation satisfaction	0.1	0.1	0.5	0.2	-0.7	-0.3	0.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	0.2	0.2	0.5	0.4
Alcohol drinker status: Never	0.1	0.1	0.5	0.1	-0.2	-0.2	0.2	0.7
Neuroticism	0.0	0.1	0.4	-0.3	-0.1	0.0	0.0	-0.6
Hair Pigment	0.0	0.5	1.4	0.4	0.5	0.9	1.2	0.1
Number of live births	0.0	0.0	0.1	0.1	0.2	0.0	-0.2	0.3

Hub : Genes

UBLCP1

Models

Trait associations